                         SEQUENCE LISTING

<110>  Numab Therapeutics AG
 
<120>  COMBINATION TREATMENT

<130>  116994P877PC

<150>  EP20203110.0
<151>  2020-10-21

<160>  241   

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  1

Gly Phe Ser Phe Ser Asn Ser Tyr Trp Ile Cys 
1               5                   10      


<210>  2
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  2

Cys Thr Phe Val Gly Ser Ser Asp Ser Thr Tyr Tyr Ala Asn Trp Ala 
1               5                   10                  15      


Lys Gly 
        


<210>  3
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  3

Arg His Pro Ser Asp Ala Val Tyr Gly Tyr Ala Asn Asn Leu 
1               5                   10                  


<210>  4
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  4

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Lys Val Ser Gly Phe Ser Phe Ser Asn Ser 
            20                  25                  30          


Tyr Trp Ile Cys Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Thr Phe Val Gly Ser Ser Asp Ser Thr Tyr Tyr Ala Asn 
    50                  55                  60                  


Trp Ala Lys Gly Arg Val Thr Ile Ser Val Asp Ser Ser Lys Asn Gln 
65                  70                  75                  80  


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg His Pro Ser Asp Ala Val Tyr Gly Tyr Ala Asn Asn 
            100                 105                 110         


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  5
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  5

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Lys Val Ser Gly Phe Ser Phe Ser Asn Ser 
            20                  25                  30          


Tyr Trp Ile Cys Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Thr Phe Val Gly Ser Ser Asp Ser Thr Tyr Tyr Ala Asn 
    50                  55                  60                  


Trp Ala Lys Gly Arg Val Thr Ile Ser Val Asp Ser Ser Lys Asn Gln 
65                  70                  75                  80  


Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
                85                  90                  95      


Phe Cys Ala Arg His Pro Ser Asp Ala Val Tyr Gly Tyr Ala Asn Asn 
            100                 105                 110         


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  6
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  6

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Lys Ala Ser Gly Phe Ser Phe Ser Asn Ser 
            20                  25                  30          


Tyr Trp Ile Cys Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Thr Phe Val Gly Ser Ser Asp Ser Thr Tyr Tyr Ala Asn 
    50                  55                  60                  


Trp Ala Lys Gly Arg Val Thr Ile Ser Lys Asp Ser Ser Lys Asn Gln 
65                  70                  75                  80  


Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
                85                  90                  95      


Phe Cys Ala Arg His Pro Ser Asp Ala Val Tyr Gly Tyr Ala Asn Asn 
            100                 105                 110         


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  7
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  7

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asn Ser 
            20                  25                  30          


Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Thr Phe Val Gly Ser Ser Asp Ser Thr Tyr Tyr Ala Asn 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg His Pro Ser Asp Ala Val Tyr Gly Tyr Ala Asn Asn 
            100                 105                 110         


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  8

Gln Ala Ser Gln Ser Ile Asn Asn Val Leu Ala 
1               5                   10      


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  9

Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  10

Gln Ser Ser Tyr Gly Asn Tyr Gly Asp 
1               5                   


<210>  11
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  11

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Asn Val 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Ser Tyr Gly Asn Tyr Gly 
                85                  90                  95      


Asp Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105             


<210>  12
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  12

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Asn Val 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Ser Tyr Gly Asn Tyr Gly 
                85                  90                  95      


Asp Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105             


<210>  13
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  13

Asp Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Asn Val 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Ser Tyr Gly Asn Tyr Gly 
                85                  90                  95      


Asp Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105             


<210>  14
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  14

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Asn Val 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Ser Tyr Gly Asn Tyr Gly 
                85                  90                  95      


Asp Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly 
            100                 105             


<210>  15
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  15

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Asn Val 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Ser Tyr Gly Asn Tyr Gly 
                85                  90                  95      


Asp Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
    130                 135                 140                 


Thr Leu Ser Leu Thr Cys Lys Val Ser Gly Phe Ser Phe Ser Asn Ser 
145                 150                 155                 160 


Tyr Trp Ile Cys Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
                165                 170                 175     


Ile Gly Cys Thr Phe Val Gly Ser Ser Asp Ser Thr Tyr Tyr Ala Asn 
            180                 185                 190         


Trp Ala Lys Gly Arg Val Thr Ile Ser Val Asp Ser Ser Lys Asn Gln 
        195                 200                 205             


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
    210                 215                 220                 


Tyr Cys Ala Arg His Pro Ser Asp Ala Val Tyr Gly Tyr Ala Asn Asn 
225                 230                 235                 240 


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250         


<210>  16
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  16

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Asn Val 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Ser Tyr Gly Asn Tyr Gly 
                85                  90                  95      


Asp Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
    130                 135                 140                 


Thr Leu Ser Leu Thr Cys Lys Val Ser Gly Phe Ser Phe Ser Asn Ser 
145                 150                 155                 160 


Tyr Trp Ile Cys Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
                165                 170                 175     


Ile Gly Cys Thr Phe Val Gly Ser Ser Asp Ser Thr Tyr Tyr Ala Asn 
            180                 185                 190         


Trp Ala Lys Gly Arg Val Thr Ile Ser Val Asp Ser Ser Lys Asn Gln 
        195                 200                 205             


Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
    210                 215                 220                 


Phe Cys Ala Arg His Pro Ser Asp Ala Val Tyr Gly Tyr Ala Asn Asn 
225                 230                 235                 240 


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250         


<210>  17
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  17

Asp Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Asn Val 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Ser Tyr Gly Asn Tyr Gly 
                85                  90                  95      


Asp Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
    130                 135                 140                 


Thr Leu Ser Leu Thr Cys Lys Ala Ser Gly Phe Ser Phe Ser Asn Ser 
145                 150                 155                 160 


Tyr Trp Ile Cys Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
                165                 170                 175     


Ile Gly Cys Thr Phe Val Gly Ser Ser Asp Ser Thr Tyr Tyr Ala Asn 
            180                 185                 190         


Trp Ala Lys Gly Arg Val Thr Ile Ser Lys Asp Ser Ser Lys Asn Gln 
        195                 200                 205             


Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
    210                 215                 220                 


Phe Cys Ala Arg His Pro Ser Asp Ala Val Tyr Gly Tyr Ala Asn Asn 
225                 230                 235                 240 


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250         


<210>  18
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  18

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Asn Val 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Ser Tyr Gly Asn Tyr Gly 
                85                  90                  95      


Asp Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
    130                 135                 140                 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asn Ser 
145                 150                 155                 160 


Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp 
                165                 170                 175     


Ile Gly Cys Thr Phe Val Gly Ser Ser Asp Ser Thr Tyr Tyr Ala Asn 
            180                 185                 190         


Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
        195                 200                 205             


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
    210                 215                 220                 


Tyr Cys Ala Arg His Pro Ser Asp Ala Val Tyr Gly Tyr Ala Asn Asn 
225                 230                 235                 240 


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250         


<210>  19
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  19

Gly Phe Ser Phe Asn Asn Asp Tyr Asp Met Cys 
1               5                   10      


<210>  20
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  20

Cys Ile Asp Thr Gly Asp Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
1               5                   10                  15      


Gly 
    


<210>  21
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  21

Arg Glu Ala Ala Ser Ser Ser Gly Tyr Gly Met Gly Tyr Phe Asp Leu 
1               5                   10                  15      


<210>  22
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  22

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Lys Val Ser Gly Phe Ser Phe Asn Asn Asp 
            20                  25                  30          


Tyr Asp Met Cys Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Ile Asp Thr Gly Asp Gly Ser Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Lys Gly Arg Val Thr Ile Ser Val Asp Ser Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Ala Ala Ser Ser Ser Gly Tyr Gly Met Gly Tyr Phe 
            100                 105                 110         


Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  23
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  23

Gln Ser Ser Gln Ser Val Tyr Asp Asn Asn Trp Leu Ala 
1               5                   10              


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  24

Arg Ala Ser Asn Leu Ala Ser 
1               5           


<210>  25
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  25

Gln Gly Thr Tyr Leu Ser Ser Asn Trp Tyr Trp Ala 
1               5                   10          


<210>  26
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  26

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Tyr Asp Asn 
            20                  25                  30          


Asn Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Thr Tyr Leu Ser 
                85                  90                  95      


Ser Asn Trp Tyr Trp Ala Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110         


Gly 
    


<210>  27
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  27

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Tyr Asp Asn 
            20                  25                  30          


Asn Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Thr Tyr Leu Ser 
                85                  90                  95      


Ser Asn Trp Tyr Trp Ala Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110         


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu 
    130                 135                 140                 


Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Lys Val Ser Gly Phe 
145                 150                 155                 160 


Ser Phe Asn Asn Asp Tyr Asp Met Cys Trp Ile Arg Gln Pro Pro Gly 
                165                 170                 175     


Lys Gly Leu Glu Trp Ile Gly Cys Ile Asp Thr Gly Asp Gly Ser Thr 
            180                 185                 190         


Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Val Thr Ile Ser Val Asp Ser 
        195                 200                 205             


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Arg Glu Ala Ala Ser Ser Ser Gly Tyr 
225                 230                 235                 240 


Gly Met Gly Tyr Phe Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val 
                245                 250                 255     


Ser Ser 
        


<210>  28
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  28

Gly Phe Ser Phe Ser Ala Asn Tyr Tyr Pro Cys 
1               5                   10      


<210>  29
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  29

Cys Ile Tyr Gly Gly Ser Ser Asp Ile Thr Tyr Asp Ala Asn Trp Thr 
1               5                   10                  15      


Lys 
    


<210>  30
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  30

Arg Ser Ala Trp Tyr Ser Gly Trp Gly Gly Asp Leu 
1               5                   10          


<210>  31
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  31

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ala Asn 
            20                  25                  30          


Tyr Tyr Pro Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Ile Tyr Gly Gly Ser Ser Asp Ile Thr Tyr Asp Ala Asn 
    50                  55                  60                  


Trp Thr Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Ser Ala Trp Tyr Ser Gly Trp Gly Gly Asp Leu Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  32
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  32

Glu Ser Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ala Asn 
            20                  25                  30          


Tyr Tyr Pro Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Ile Tyr Gly Gly Ser Ser Asp Ile Thr Tyr Asp Ala Asn 
    50                  55                  60                  


Trp Thr Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Phe Cys Ala Arg Ser Ala Trp Tyr Ser Gly Trp Gly Gly Asp Leu Trp 
            100                 105                 110         


Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  33
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  33

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ala Asn 
            20                  25                  30          


Tyr Tyr Pro Cys Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Ile Tyr Gly Gly Ser Ser Asp Ile Thr Tyr Asp Ala Asn 
    50                  55                  60                  


Trp Thr Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Ser Ala Trp Tyr Ser Gly Trp Gly Gly Asp Leu Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  34
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  34

Gln Ala Ser Gln Ser Ile Ser Asn Arg Leu Ala 
1               5                   10      


<210>  35
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  35

Ser Ala Ser Thr Leu Ala Ser 
1               5           


<210>  36
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  36

Gln Ser Thr Tyr Tyr Gly Asn Asp Gly Asn Ala 
1               5                   10      


<210>  37
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  37

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Asn Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Tyr Gly Asn Asp 
                85                  90                  95      


Gly Asn Ala Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110 


<210>  38
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  38

Asp Phe Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Asn Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Tyr Gly Asn Asp 
                85                  90                  95      


Gly Asn Ala Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110 


<210>  39
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  39

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Asn Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Tyr Gly Asn Asp 
                85                  90                  95      


Gly Asn Ala Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110 


<210>  40
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  40

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Asn Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Tyr Gly Asn Asp 
                85                  90                  95      


Gly Asn Ala Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser 
145                 150                 155                 160 


Ala Asn Tyr Tyr Pro Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Ile Gly Cys Ile Tyr Gly Gly Ser Ser Asp Ile Thr Tyr Asp 
            180                 185                 190         


Ala Asn Trp Thr Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
        195                 200                 205             


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Arg Ser Ala Trp Tyr Ser Gly Trp Gly Gly Asp 
225                 230                 235                 240 


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250         


<210>  41
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  41

Asp Phe Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Asn Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Tyr Gly Asn Asp 
                85                  90                  95      


Gly Asn Ala Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Glu Ser Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser 
145                 150                 155                 160 


Ala Asn Tyr Tyr Pro Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Ile Gly Cys Ile Tyr Gly Gly Ser Ser Asp Ile Thr Tyr Asp 
            180                 185                 190         


Ala Asn Trp Thr Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
        195                 200                 205             


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Phe Cys Ala Arg Ser Ala Trp Tyr Ser Gly Trp Gly Gly Asp 
225                 230                 235                 240 


Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
                245                 250         


<210>  42
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  42

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Asn Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Tyr Gly Asn Asp 
                85                  90                  95      


Gly Asn Ala Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser 
145                 150                 155                 160 


Ala Asn Tyr Tyr Pro Cys Trp Val Arg Gln Ala Pro Gly Lys Cys Leu 
                165                 170                 175     


Glu Trp Ile Gly Cys Ile Tyr Gly Gly Ser Ser Asp Ile Thr Tyr Asp 
            180                 185                 190         


Ala Asn Trp Thr Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
        195                 200                 205             


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Arg Ser Ala Trp Tyr Ser Gly Trp Gly Gly Asp 
225                 230                 235                 240 


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250         


<210>  43
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  43

Gly Phe Ser Phe Asn Ser Asp Tyr Trp Ile Tyr 
1               5                   10      


<210>  44
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  44

Ser Ile Tyr Gly Gly Ser Ser Gly Asn Thr Gln Tyr Ala Ser Trp Ala 
1               5                   10                  15      


Gln Gly 
        


<210>  45
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  45

Arg Gly Tyr Val Asp Tyr Gly Gly Ala Thr Asp Leu 
1               5                   10          


<210>  46
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  46

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Lys Val Ser Gly Phe Ser Phe Asn Ser Asp 
            20                  25                  30          


Tyr Trp Ile Tyr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Tyr Gly Gly Ser Ser Gly Asn Thr Gln Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Gln Gly Arg Val Thr Ile Ser Val Asp Ser Ser Lys Asn Gln 
65                  70                  75                  80  


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Gly Tyr Val Asp Tyr Gly Gly Ala Thr Asp Leu Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  47
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  47

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Ser Phe Asn Ser Asp 
            20                  25                  30          


Tyr Trp Ile Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Ser Ile Tyr Gly Gly Ser Ser Gly Asn Thr Gln Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr 
65                  70                  75                  80  


Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Gly Tyr Val Asp Tyr Gly Gly Ala Thr Asp Leu Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  48
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  48

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asn Ser Asp 
            20                  25                  30          


Tyr Trp Ile Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ala Ser Ile Tyr Gly Gly Ser Ser Gly Asn Thr Gln Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Phe Cys Ala Arg Gly Tyr Val Asp Tyr Gly Gly Ala Thr Asp Leu Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  49
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  49

Gln Ala Ser Gln Ser Ile Gly Thr Tyr Leu Ala 
1               5                   10      


<210>  50
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  50

Arg Ala Phe Ile Leu Ala Ser 
1               5           


<210>  51
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  51

Gln Ser Asn Phe Tyr Ser Asp Ser Thr Thr Ile Gly Pro Asn Ala 
1               5                   10                  15  


<210>  52
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  52

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Gly Thr Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Phe Ile Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Asn Phe Tyr Ser Asp Ser 
                85                  90                  95      


Thr Thr Ile Gly Pro Asn Ala Phe Gly Thr Gly Thr Lys Val Thr Val 
            100                 105                 110         


Leu Gly 
        


<210>  53
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  53

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Gly Thr Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Phe Ile Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Asn Phe Tyr Ser Asp Ser 
                85                  90                  95      


Thr Thr Ile Gly Pro Asn Ala Phe Gly Thr Gly Thr Lys Val Thr Val 
            100                 105                 110         


Leu Gly 
        


<210>  54
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  54

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Gly Thr Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Phe Ile Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Asn Phe Tyr Ser Asp Ser 
                85                  90                  95      


Thr Thr Ile Gly Pro Asn Ala Phe Gly Thr Gly Thr Lys Val Thr Val 
            100                 105                 110         


Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
    130                 135                 140                 


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Lys Val Ser Gly 
145                 150                 155                 160 


Phe Ser Phe Asn Ser Asp Tyr Trp Ile Tyr Trp Ile Arg Gln Pro Pro 
                165                 170                 175     


Gly Lys Gly Leu Glu Trp Ile Gly Ser Ile Tyr Gly Gly Ser Ser Gly 
            180                 185                 190         


Asn Thr Gln Tyr Ala Ser Trp Ala Gln Gly Arg Val Thr Ile Ser Val 
        195                 200                 205             


Asp Ser Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala 
    210                 215                 220                 


Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Val Asp Tyr Gly 
225                 230                 235                 240 


Gly Ala Thr Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 255     


<210>  55
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  55

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Gly Thr Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Phe Ile Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Asn Phe Tyr Ser Asp Ser 
                85                  90                  95      


Thr Thr Ile Gly Pro Asn Ala Phe Gly Thr Gly Thr Lys Val Thr Val 
            100                 105                 110         


Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
    130                 135                 140                 


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
145                 150                 155                 160 


Phe Ser Phe Asn Ser Asp Tyr Trp Ile Tyr Trp Val Arg Gln Ala Pro 
                165                 170                 175     


Gly Gln Gly Leu Glu Trp Met Gly Ser Ile Tyr Gly Gly Ser Ser Gly 
            180                 185                 190         


Asn Thr Gln Tyr Ala Ser Trp Ala Gln Gly Arg Val Thr Met Thr Arg 
        195                 200                 205             


Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
    210                 215                 220                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Val Asp Tyr Gly 
225                 230                 235                 240 


Gly Ala Thr Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 255     


<210>  56
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  56

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Gly Thr Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Phe Ile Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Asn Phe Tyr Ser Asp Ser 
                85                  90                  95      


Thr Thr Ile Gly Pro Asn Ala Phe Gly Thr Gly Thr Lys Val Thr Val 
            100                 105                 110         


Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    130                 135                 140                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
145                 150                 155                 160 


Phe Ser Phe Asn Ser Asp Tyr Trp Ile Tyr Trp Val Arg Gln Ala Pro 
                165                 170                 175     


Gly Lys Gly Leu Glu Trp Ile Ala Ser Ile Tyr Gly Gly Ser Ser Gly 
            180                 185                 190         


Asn Thr Gln Tyr Ala Ser Trp Ala Gln Gly Arg Phe Thr Ile Ser Arg 
        195                 200                 205             


Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    210                 215                 220                 


Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg Gly Tyr Val Asp Tyr Gly 
225                 230                 235                 240 


Gly Ala Thr Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 255     


<210>  57
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  57

Gly Phe Ser Phe Ser Ser Gly Tyr Asp Met Cys 
1               5                   10      


<210>  58
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  58

Cys Val Val Ala Gly Ser Val Asp Ile Thr Tyr Tyr Ala Ser Trp Ala 
1               5                   10                  15      


Lys Gly 
        


<210>  59
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  59

Arg Lys Asp Ala Tyr Ser Asp Ala Phe Asn Leu 
1               5                   10      


<210>  60
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  60

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Lys Val Ser Gly Phe Ser Phe Ser Ser Gly 
            20                  25                  30          


Tyr Asp Met Cys Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Val Val Ala Gly Ser Val Asp Ile Thr Tyr Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Val Thr Ile Ser Val Asp Ser Ser Lys Asn Gln 
65                  70                  75                  80  


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Lys Asp Ala Tyr Ser Asp Ala Phe Asn Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  61
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  61

Gln Ser Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Lys Ala Ser Gly Phe Ser Phe Ser Ser Gly 
            20                  25                  30          


Tyr Asp Met Cys Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ala Cys Val Val Ala Gly Ser Val Asp Ile Thr Tyr Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Val Thr Ile Ser Lys Asp Ser Ser Lys Asn Gln 
65                  70                  75                  80  


Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
                85                  90                  95      


Phe Cys Ala Arg Lys Asp Ala Tyr Ser Asp Ala Phe Asn Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  62
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  62

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Lys Ala Ser Gly Phe Ser Phe Ser Ser Gly 
            20                  25                  30          


Tyr Asp Met Cys Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ala Cys Val Val Ala Gly Ser Val Asp Ile Thr Tyr Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Val Thr Ile Ser Lys Asp Ser Ser Lys Asn Gln 
65                  70                  75                  80  


Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Lys Asp Ala Tyr Ser Asp Ala Phe Asn Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  63
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  63

Gln Ala Ser Gln Ser Ile Asn Asp Tyr Leu Ala 
1               5                   10      


<210>  64
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  64

Lys Ala Ser Thr Leu Ala Ser 
1               5           


<210>  65
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  65

Gln Gln Gly Tyr Ile Ile Thr Asp Ile Asp Asn Val 
1               5                   10          


<210>  66
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  66

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Asp Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ile Ile Thr Asp 
                85                  90                  95      


Ile Asp Asn Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110     


<210>  67
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  67

Asp Phe Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Asp Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ile Ile Thr Asp 
                85                  90                  95      


Ile Asp Asn Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110     


<210>  68
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  68

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Asp Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ile Ile Thr Asp 
                85                  90                  95      


Ile Asp Asn Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
    130                 135                 140                 


Pro Ser Glu Thr Leu Ser Leu Thr Cys Lys Val Ser Gly Phe Ser Phe 
145                 150                 155                 160 


Ser Ser Gly Tyr Asp Met Cys Trp Ile Arg Gln Pro Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Ile Gly Cys Val Val Ala Gly Ser Val Asp Ile Thr Tyr 
            180                 185                 190         


Tyr Ala Ser Trp Ala Lys Gly Arg Val Thr Ile Ser Val Asp Ser Ser 
        195                 200                 205             


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Ala Arg Lys Asp Ala Tyr Ser Asp Ala Phe Asn 
225                 230                 235                 240 


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250         


<210>  69
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  69

Asp Phe Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Asp Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ile Ile Thr Asp 
                85                  90                  95      


Ile Asp Asn Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Ser Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
    130                 135                 140                 


Pro Ser Glu Thr Leu Ser Leu Thr Cys Lys Ala Ser Gly Phe Ser Phe 
145                 150                 155                 160 


Ser Ser Gly Tyr Asp Met Cys Trp Val Arg Gln Pro Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Ile Ala Cys Val Val Ala Gly Ser Val Asp Ile Thr Tyr 
            180                 185                 190         


Tyr Ala Ser Trp Ala Lys Gly Arg Val Thr Ile Ser Lys Asp Ser Ser 
        195                 200                 205             


Lys Asn Gln Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
    210                 215                 220                 


Ala Val Tyr Phe Cys Ala Arg Lys Asp Ala Tyr Ser Asp Ala Phe Asn 
225                 230                 235                 240 


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250         


<210>  70
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  70

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Asp Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ile Ile Thr Asp 
                85                  90                  95      


Ile Asp Asn Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
    130                 135                 140                 


Pro Ser Glu Thr Leu Ser Leu Thr Cys Lys Ala Ser Gly Phe Ser Phe 
145                 150                 155                 160 


Ser Ser Gly Tyr Asp Met Cys Trp Val Arg Gln Pro Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Ile Ala Cys Val Val Ala Gly Ser Val Asp Ile Thr Tyr 
            180                 185                 190         


Tyr Ala Ser Trp Ala Lys Gly Arg Val Thr Ile Ser Lys Asp Ser Ser 
        195                 200                 205             


Lys Asn Gln Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Ala Arg Lys Asp Ala Tyr Ser Asp Ala Phe Asn 
225                 230                 235                 240 


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250         


<210>  71
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  71

Gly Phe Ser Leu Ser Ser Asn Ala Met Gly 
1               5                   10  


<210>  72
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  72

Ile Ile Ser Val Gly Gly Phe Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  73
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  73

Arg Asp Arg His Gly Gly Asp Ser Ser Gly Ala Phe Tyr Leu 
1               5                   10                  


<210>  74
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  74

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Asn 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Ile Ile Ser Val Gly Gly Phe Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Asp Arg His Gly Gly Asp Ser Ser Gly Ala Phe Tyr Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  75
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  75

Gln Ser Ser Glu Ser Val Tyr Ser Asn Asn Gln Leu Ser 
1               5                   10              


<210>  76
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  76

Asp Ala Ser Asp Leu Ala Ser 
1               5           


<210>  77
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  77

Ala Gly Gly Phe Ser Ser Ser Ser Asp Thr Ala 
1               5                   10      


<210>  78
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  78

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Glu Ser Val Tyr Ser Asn 
            20                  25                  30          


Asn Gln Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Ser 
                85                  90                  95      


Ser Ser Asp Thr Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


<210>  79
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  79

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Glu Ser Val Tyr Ser Asn 
            20                  25                  30          


Asn Gln Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Ser 
                85                  90                  95      


Ser Ser Asp Thr Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser 
145                 150                 155                 160 


Leu Ser Ser Asn Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Tyr Ile Gly Ile Ile Ser Val Gly Gly Phe Thr Tyr Tyr Ala 
            180                 185                 190         


Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
        195                 200                 205             


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr 
    210                 215                 220                 


Tyr Phe Cys Ala Arg Asp Arg His Gly Gly Asp Ser Ser Gly Ala Phe 
225                 230                 235                 240 


Tyr Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250             


<210>  80
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  80

Gly Phe Ser Phe Ser Ser Ser Tyr Trp Ile Cys 
1               5                   10      


<210>  81
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  81

Cys Val Phe Thr Gly Asp Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys 
1               5                   10                  15      


Gly 
    


<210>  82
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  82

Arg Pro Val Ser Val Tyr Tyr Tyr Gly Met Asp Leu 
1               5                   10          


<210>  83
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  83

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ser 
            20                  25                  30          


Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Gly Cys Val Phe Thr Gly Asp Gly Thr Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Arg Pro Val Ser Val Tyr Tyr Tyr Gly Met Asp Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  84
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  84

Gln Ala Ser Gln Ile Ile Ser Ser Arg Ser Ala 
1               5                   10      


<210>  85
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  85

Gln Ala Ser Lys Leu Ala Ser 
1               5           


<210>  86
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  86

Gln Cys Thr Tyr Ile Asp Ser Asn Phe Gly Ala 
1               5                   10      


<210>  87
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  87

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ile Ile Ser Ser Arg 
            20                  25                  30          


Ser Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gln Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Cys Thr Tyr Ile Asp Ser Asn 
                85                  90                  95      


Phe Gly Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110 


<210>  88
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  88

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ile Ile Ser Ser Arg 
            20                  25                  30          


Ser Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gln Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Cys Thr Tyr Ile Asp Ser Asn 
                85                  90                  95      


Phe Gly Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser 
145                 150                 155                 160 


Ser Ser Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Val Gly Cys Val Phe Thr Gly Asp Gly Thr Thr Tyr Tyr Ala 
            180                 185                 190         


Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
        195                 200                 205             


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr 
    210                 215                 220                 


Tyr Phe Cys Ala Arg Pro Val Ser Val Tyr Tyr Tyr Gly Met Asp Leu 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  89
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210>  90
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  91
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  91

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ala Asn 
            20                  25                  30          


Tyr Tyr Pro Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Ile Tyr Gly Gly Ser Ser Asp Ile Thr Tyr Asp Ala Asn 
    50                  55                  60                  


Trp Thr Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Ser Ala Trp Tyr Ser Gly Trp Gly Gly Asp Leu Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  92
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  92

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Lys Val Ser Gly Phe Ser Phe Ser Asn Ser 
            20                  25                  30          


Tyr Trp Ile Cys Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Thr Phe Val Gly Ser Ser Asp Ser Thr Tyr Tyr Ala Asn 
    50                  55                  60                  


Trp Ala Lys Gly Arg Val Thr Ile Ser Val Asp Ser Ser Lys Asn Gln 
65                  70                  75                  80  


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg His Pro Ser Asp Ala Val Tyr Gly Tyr Ala Asn Asn 
            100                 105                 110         


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  93
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  93

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Asn Val 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Ser Tyr Gly Asn Tyr Gly 
                85                  90                  95      


Asp Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105             


<210>  94
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  94

Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
1               5                   10      


<210>  95
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  95

Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
1               5                   10      


<210>  96
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  96

Phe Gly Gly Gly Thr Gln Leu Ile Ile Leu Gly 
1               5                   10      


<210>  97
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  97

Phe Gly Glu Gly Thr Glu Leu Thr Val Leu Gly 
1               5                   10      


<210>  98
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  98

Phe Gly Ser Gly Thr Lys Val Thr Val Leu Gly 
1               5                   10      


<210>  99
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  99

Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly 
1               5                   10      


<210>  100
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  100

Phe Gly Gly Gly Thr Gln Leu Thr Ala Leu Gly 
1               5                   10      


<210>  101
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  101

Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly 
1               5                   10      


<210>  102
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  102

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  103
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  103

Gly Gly Gly Gly Ser 
1               5   


<210>  104
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  104

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  105
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  105

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Asp Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ile Ile Thr Asp 
                85                  90                  95      


Ile Asp Asn Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 
        115                 120                 125             


Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Lys Val Ser Gly Phe Ser 
    130                 135                 140                 


Phe Ser Asn Ser Tyr Trp Ile Cys Trp Ile Arg Gln Pro Pro Gly Lys 
145                 150                 155                 160 


Gly Leu Glu Trp Ile Gly Cys Thr Phe Val Gly Ser Ser Asp Ser Thr 
                165                 170                 175     


Tyr Tyr Ala Asn Trp Ala Lys Gly Arg Val Thr Ile Ser Val Asp Ser 
            180                 185                 190         


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
        195                 200                 205             


Thr Ala Val Tyr Tyr Cys Ala Arg His Pro Ser Asp Ala Val Tyr Gly 
    210                 215                 220                 


Tyr Ala Asn Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Ser Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            260                 265                 270         


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile 
        275                 280                 285             


Asn Asn Val Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    290                 295                 300                 


Leu Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg 
305                 310                 315                 320 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                325                 330                 335     


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Ser Tyr Gly 
            340                 345                 350         


Asn Tyr Gly Asp Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
        355                 360                 365             


Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 
    370                 375                 380                 


Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Lys Val Ser Gly Phe Ser 
385                 390                 395                 400 


Phe Ser Ser Gly Tyr Asp Met Cys Trp Ile Arg Gln Pro Pro Gly Lys 
                405                 410                 415     


Gly Leu Glu Trp Ile Gly Cys Val Val Ala Gly Ser Val Asp Ile Thr 
            420                 425                 430         


Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Val Thr Ile Ser Val Asp Ser 
        435                 440                 445             


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
    450                 455                 460                 


Thr Ala Val Tyr Tyr Cys Ala Arg Lys Asp Ala Tyr Ser Asp Ala Phe 
465                 470                 475                 480 


Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                485                 490             


<210>  106
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  106

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Asp Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ile Ile Thr Asp 
                85                  90                  95      


Ile Asp Asn Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
        115                 120                 125             


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser 
    130                 135                 140                 


Phe Asn Asn Asp Tyr Asp Met Cys Trp Val Arg Gln Ala Pro Gly Lys 
145                 150                 155                 160 


Gly Leu Glu Trp Ile Gly Cys Ile Asp Thr Gly Asp Gly Ser Thr Tyr 
                165                 170                 175     


Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
            180                 185                 190         


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
        195                 200                 205             


Ala Val Tyr Tyr Cys Ala Arg Glu Ala Ala Ser Ser Ser Gly Tyr Gly 
    210                 215                 220                 


Met Gly Tyr Phe Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            260                 265                 270         


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Ser 
        275                 280                 285             


Val Tyr Asp Asn Asn Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    290                 295                 300                 


Ala Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val 
305                 310                 315                 320 


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                325                 330                 335     


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly 
            340                 345                 350         


Thr Tyr Leu Ser Ser Asn Trp Tyr Trp Ala Phe Gly Thr Gly Thr Lys 
        355                 360                 365             


Val Thr Val Leu Gly Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu 
    370                 375                 380                 


Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys 
385                 390                 395                 400 


Lys Val Ser Gly Phe Ser Phe Ser Ser Gly Tyr Asp Met Cys Trp Ile 
                405                 410                 415     


Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Cys Val Val Ala 
            420                 425                 430         


Gly Ser Val Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Val 
        435                 440                 445             


Thr Ile Ser Val Asp Ser Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser 
    450                 455                 460                 


Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Lys Asp 
465                 470                 475                 480 


Ala Tyr Ser Asp Ala Phe Asn Leu Trp Gly Gln Gly Thr Leu Val Thr 
                485                 490                 495     


Val Ser Ser 
            


<210>  107
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  107

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Asp Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ile Ile Thr Asp 
                85                  90                  95      


Ile Asp Asn Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 
        115                 120                 125             


Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Lys Val Ser Gly Phe Ser 
    130                 135                 140                 


Phe Ser Asn Ser Tyr Trp Ile Cys Trp Val Arg Gln Pro Pro Gly Lys 
145                 150                 155                 160 


Gly Leu Glu Trp Ile Gly Cys Thr Phe Val Gly Ser Ser Asp Ser Thr 
                165                 170                 175     


Tyr Tyr Ala Asn Trp Ala Lys Gly Arg Val Thr Ile Ser Val Asp Ser 
            180                 185                 190         


Ser Lys Asn Gln Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
        195                 200                 205             


Thr Ala Val Tyr Phe Cys Ala Arg His Pro Ser Asp Ala Val Tyr Gly 
    210                 215                 220                 


Tyr Ala Asn Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Ser Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            260                 265                 270         


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile 
        275                 280                 285             


Asn Asn Val Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys 
    290                 295                 300                 


Leu Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg 
305                 310                 315                 320 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                325                 330                 335     


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Ser Tyr Gly 
            340                 345                 350         


Asn Tyr Gly Asp Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
        355                 360                 365             


Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 
    370                 375                 380                 


Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Lys Val Ser Gly Phe Ser 
385                 390                 395                 400 


Phe Ser Ser Gly Tyr Asp Met Cys Trp Ile Arg Gln Pro Pro Gly Lys 
                405                 410                 415     


Gly Leu Glu Trp Ile Gly Cys Val Val Ala Gly Ser Val Asp Ile Thr 
            420                 425                 430         


Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Val Thr Ile Ser Val Asp Ser 
        435                 440                 445             


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
    450                 455                 460                 


Thr Ala Val Tyr Tyr Cys Ala Arg Lys Asp Ala Tyr Ser Asp Ala Phe 
465                 470                 475                 480 


Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                485                 490             


<210>  108
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  108

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Asp Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ile Ile Thr Asp 
                85                  90                  95      


Ile Asp Asn Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 
        115                 120                 125             


Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Lys Ala Ser Gly Phe Ser 
    130                 135                 140                 


Phe Ser Asn Ser Tyr Trp Ile Cys Trp Val Arg Gln Pro Pro Gly Lys 
145                 150                 155                 160 


Gly Leu Glu Trp Ile Gly Cys Thr Phe Val Gly Ser Ser Asp Ser Thr 
                165                 170                 175     


Tyr Tyr Ala Asn Trp Ala Lys Gly Arg Val Thr Ile Ser Lys Asp Ser 
            180                 185                 190         


Ser Lys Asn Gln Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
        195                 200                 205             


Thr Ala Val Tyr Phe Cys Ala Arg His Pro Ser Asp Ala Val Tyr Gly 
    210                 215                 220                 


Tyr Ala Asn Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Ser Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            260                 265                 270         


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile 
        275                 280                 285             


Asn Asn Val Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys 
    290                 295                 300                 


Leu Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg 
305                 310                 315                 320 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                325                 330                 335     


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Ser Tyr Gly 
            340                 345                 350         


Asn Tyr Gly Asp Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
        355                 360                 365             


Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 
    370                 375                 380                 


Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Lys Val Ser Gly Phe Ser 
385                 390                 395                 400 


Phe Ser Ser Gly Tyr Asp Met Cys Trp Ile Arg Gln Pro Pro Gly Lys 
                405                 410                 415     


Gly Leu Glu Trp Ile Gly Cys Val Val Ala Gly Ser Val Asp Ile Thr 
            420                 425                 430         


Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Val Thr Ile Ser Val Asp Ser 
        435                 440                 445             


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
    450                 455                 460                 


Thr Ala Val Tyr Tyr Cys Ala Arg Lys Asp Ala Tyr Ser Asp Ala Phe 
465                 470                 475                 480 


Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                485                 490             


<210>  109
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  109

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Asp Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ile Ile Thr Asp 
                85                  90                  95      


Ile Asp Asn Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 
        115                 120                 125             


Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Lys Val Ser Gly Phe Ser 
    130                 135                 140                 


Phe Ser Asn Ser Tyr Trp Ile Cys Trp Ile Arg Gln Pro Pro Gly Lys 
145                 150                 155                 160 


Gly Leu Glu Trp Ile Gly Cys Thr Phe Val Gly Ser Ser Asp Ser Thr 
                165                 170                 175     


Tyr Tyr Ala Asn Trp Ala Lys Gly Arg Val Thr Ile Ser Val Asp Ser 
            180                 185                 190         


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
        195                 200                 205             


Thr Ala Val Tyr Tyr Cys Ala Arg His Pro Ser Asp Ala Val Tyr Gly 
    210                 215                 220                 


Tyr Ala Asn Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Ser Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            260                 265                 270         


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile 
        275                 280                 285             


Asn Asn Val Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    290                 295                 300                 


Leu Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg 
305                 310                 315                 320 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                325                 330                 335     


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Ser Tyr Gly 
            340                 345                 350         


Asn Tyr Gly Asp Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
        355                 360                 365             


Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 
    370                 375                 380                 


Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Lys Val Ser Gly Phe Ser 
385                 390                 395                 400 


Phe Ser Ser Gly Tyr Asp Met Cys Trp Val Arg Gln Pro Pro Gly Lys 
                405                 410                 415     


Gly Leu Glu Trp Ile Ala Cys Val Val Ala Gly Ser Val Asp Ile Thr 
            420                 425                 430         


Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Val Thr Ile Ser Val Asp Ser 
        435                 440                 445             


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
    450                 455                 460                 


Thr Ala Val Tyr Phe Cys Ala Arg Lys Asp Ala Tyr Ser Asp Ala Phe 
465                 470                 475                 480 


Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                485                 490             


<210>  110
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  110

Asp Phe Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Asp Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ile Ile Thr Asp 
                85                  90                  95      


Ile Asp Asn Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 
        115                 120                 125             


Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Lys Val Ser Gly Phe Ser 
    130                 135                 140                 


Phe Ser Asn Ser Tyr Trp Ile Cys Trp Ile Arg Gln Pro Pro Gly Lys 
145                 150                 155                 160 


Gly Leu Glu Trp Ile Gly Cys Thr Phe Val Gly Ser Ser Asp Ser Thr 
                165                 170                 175     


Tyr Tyr Ala Asn Trp Ala Lys Gly Arg Val Thr Ile Ser Val Asp Ser 
            180                 185                 190         


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
        195                 200                 205             


Thr Ala Val Tyr Tyr Cys Ala Arg His Pro Ser Asp Ala Val Tyr Gly 
    210                 215                 220                 


Tyr Ala Asn Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Ser Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            260                 265                 270         


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile 
        275                 280                 285             


Asn Asn Val Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    290                 295                 300                 


Leu Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg 
305                 310                 315                 320 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                325                 330                 335     


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Ser Tyr Gly 
            340                 345                 350         


Asn Tyr Gly Asp Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
        355                 360                 365             


Gly Gly Gly Ser Gln Ser Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 
    370                 375                 380                 


Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Lys Ala Ser Gly Phe Ser 
385                 390                 395                 400 


Phe Ser Ser Gly Tyr Asp Met Cys Trp Val Arg Gln Pro Pro Gly Lys 
                405                 410                 415     


Gly Leu Glu Trp Ile Ala Cys Val Val Ala Gly Ser Val Asp Ile Thr 
            420                 425                 430         


Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Val Thr Ile Ser Lys Asp Ser 
        435                 440                 445             


Ser Lys Asn Gln Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
    450                 455                 460                 


Thr Ala Val Tyr Phe Cys Ala Arg Lys Asp Ala Tyr Ser Asp Ala Phe 
465                 470                 475                 480 


Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                485                 490             


<210>  111
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  111

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Ala Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Asp Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ile Ile Thr Asp 
                85                  90                  95      


Ile Asp Asn Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 
        115                 120                 125             


Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Lys Val Ser Gly Phe Ser 
    130                 135                 140                 


Phe Ser Asn Ser Tyr Trp Ile Cys Trp Ile Arg Gln Pro Pro Gly Lys 
145                 150                 155                 160 


Gly Leu Glu Trp Ile Gly Cys Thr Phe Val Gly Ser Ser Asp Ser Thr 
                165                 170                 175     


Tyr Tyr Ala Asn Trp Ala Lys Gly Arg Val Thr Ile Ser Val Asp Ser 
            180                 185                 190         


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
        195                 200                 205             


Thr Ala Val Tyr Tyr Cys Ala Arg His Pro Ser Asp Ala Val Tyr Gly 
    210                 215                 220                 


Tyr Ala Asn Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Ser Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            260                 265                 270         


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile 
        275                 280                 285             


Asn Asn Val Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    290                 295                 300                 


Leu Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg 
305                 310                 315                 320 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                325                 330                 335     


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Ser Tyr Gly 
            340                 345                 350         


Asn Tyr Gly Asp Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
        355                 360                 365             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    370                 375                 380                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser 
385                 390                 395                 400 


Phe Ser Ser Gly Tyr Asp Met Cys Trp Val Arg Gln Ala Pro Gly Lys 
                405                 410                 415     


Gly Leu Glu Trp Val Gly Cys Val Val Ala Gly Ser Val Asp Ile Thr 
            420                 425                 430         


Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        435                 440                 445             


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    450                 455                 460                 


Thr Ala Thr Tyr Tyr Cys Ala Arg Lys Asp Ala Tyr Ser Asp Ala Phe 
465                 470                 475                 480 


Asn Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
                485                 490             


<210>  112
<211>  755
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  112

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Asp Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ile Ile Thr Asp 
                85                  90                  95      


Ile Asp Asn Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 
        115                 120                 125             


Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Lys Val Ser Gly Phe Ser 
    130                 135                 140                 


Phe Ser Asn Ser Tyr Trp Ile Cys Trp Ile Arg Gln Pro Pro Gly Lys 
145                 150                 155                 160 


Gly Leu Glu Trp Ile Gly Cys Thr Phe Val Gly Ser Ser Asp Ser Thr 
                165                 170                 175     


Tyr Tyr Ala Asn Trp Ala Lys Gly Arg Val Thr Ile Ser Val Asp Ser 
            180                 185                 190         


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
        195                 200                 205             


Thr Ala Val Tyr Tyr Cys Ala Arg His Pro Ser Asp Ala Val Tyr Gly 
    210                 215                 220                 


Tyr Ala Asn Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Ser Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            260                 265                 270         


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile 
        275                 280                 285             


Asn Asn Val Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    290                 295                 300                 


Leu Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg 
305                 310                 315                 320 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                325                 330                 335     


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Ser Tyr Gly 
            340                 345                 350         


Asn Tyr Gly Asp Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
        355                 360                 365             


Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 
    370                 375                 380                 


Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Lys Val Ser Gly Phe Ser 
385                 390                 395                 400 


Phe Ser Ser Gly Tyr Asp Met Cys Trp Ile Arg Gln Pro Pro Gly Lys 
                405                 410                 415     


Gly Leu Glu Trp Ile Gly Cys Val Val Ala Gly Ser Val Asp Ile Thr 
            420                 425                 430         


Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Val Thr Ile Ser Val Asp Ser 
        435                 440                 445             


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
    450                 455                 460                 


Thr Ala Val Tyr Tyr Cys Ala Arg Lys Asp Ala Tyr Ser Asp Ala Phe 
465                 470                 475                 480 


Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                485                 490                 495     


Gly Ser Gly Gly Gly Gly Ser Ile Gln Met Thr Gln Ser Pro Ser Ser 
            500                 505                 510         


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser 
        515                 520                 525             


Glu Ser Val Tyr Ser Asn Asn Gln Leu Ser Trp Tyr Gln Gln Lys Pro 
    530                 535                 540                 


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asp Leu Ala Ser 
545                 550                 555                 560 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                565                 570                 575     


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            580                 585                 590         


Ala Gly Gly Phe Ser Ser Ser Ser Asp Thr Ala Phe Gly Gly Gly Thr 
        595                 600                 605             


Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    610                 615                 620                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
625                 630                 635                 640 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                645                 650                 655     


Ala Ala Ser Gly Phe Ser Leu Ser Ser Asn Ala Met Gly Trp Val Arg 
            660                 665                 670         


Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly Ile Ile Ser Val Gly 
        675                 680                 685             


Gly Phe Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser 
    690                 695                 700                 


Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
705                 710                 715                 720 


Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Arg His Gly Gly 
                725                 730                 735     


Asp Ser Ser Gly Ala Phe Tyr Leu Trp Gly Gln Gly Thr Leu Val Thr 
            740                 745                 750         


Val Ser Ser 
        755 


<210>  113
<211>  761
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  113

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Asp Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ile Ile Thr Asp 
                85                  90                  95      


Ile Asp Asn Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 
        115                 120                 125             


Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Lys Val Ser Gly Phe Ser 
    130                 135                 140                 


Phe Asn Asn Asp Tyr Asp Met Cys Trp Ile Arg Gln Pro Pro Gly Lys 
145                 150                 155                 160 


Gly Leu Glu Trp Ile Gly Cys Ile Asp Thr Gly Asp Gly Ser Thr Tyr 
                165                 170                 175     


Tyr Ala Ser Trp Ala Lys Gly Arg Val Thr Ile Ser Val Asp Ser Ser 
            180                 185                 190         


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
        195                 200                 205             


Ala Val Tyr Tyr Cys Ala Arg Glu Ala Ala Ser Ser Ser Gly Tyr Gly 
    210                 215                 220                 


Met Gly Tyr Phe Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            260                 265                 270         


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Ser 
        275                 280                 285             


Val Tyr Asp Asn Asn Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    290                 295                 300                 


Ala Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val 
305                 310                 315                 320 


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                325                 330                 335     


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly 
            340                 345                 350         


Thr Tyr Leu Ser Ser Asn Trp Tyr Trp Ala Phe Gly Thr Gly Thr Lys 
        355                 360                 365             


Val Thr Val Leu Gly Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu 
    370                 375                 380                 


Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys 
385                 390                 395                 400 


Lys Val Ser Gly Phe Ser Phe Ser Ser Gly Tyr Asp Met Cys Trp Ile 
                405                 410                 415     


Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Cys Val Val Ala 
            420                 425                 430         


Gly Ser Val Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Val 
        435                 440                 445             


Thr Ile Ser Val Asp Ser Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser 
    450                 455                 460                 


Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Lys Asp 
465                 470                 475                 480 


Ala Tyr Ser Asp Ala Phe Asn Leu Trp Gly Gln Gly Thr Leu Val Thr 
                485                 490                 495     


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Met 
            500                 505                 510         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        515                 520                 525             


Ile Thr Cys Gln Ser Ser Glu Ser Val Tyr Ser Asn Asn Gln Leu Ser 
    530                 535                 540                 


Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp 
545                 550                 555                 560 


Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
                565                 570                 575     


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
            580                 585                 590         


Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Ser Ser Ser Asp Thr 
        595                 600                 605             


Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Gly 
    610                 615                 620                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
625                 630                 635                 640 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                645                 650                 655     


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Asn 
            660                 665                 670         


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 
        675                 680                 685             


Gly Ile Ile Ser Val Gly Gly Phe Thr Tyr Tyr Ala Ser Trp Ala Lys 
    690                 695                 700                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
705                 710                 715                 720 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
                725                 730                 735     


Arg Asp Arg His Gly Gly Asp Ser Ser Gly Ala Phe Tyr Leu Trp Gly 
            740                 745                 750         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        755                 760     


<210>  114
<211>  753
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  114

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Asp Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ile Ile Thr Asp 
                85                  90                  95      


Ile Asp Asn Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 
        115                 120                 125             


Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Lys Val Ser Gly Phe Ser 
    130                 135                 140                 


Phe Ser Asn Ser Tyr Trp Ile Cys Trp Ile Arg Gln Pro Pro Gly Lys 
145                 150                 155                 160 


Gly Leu Glu Trp Ile Gly Cys Thr Phe Val Gly Ser Ser Asp Ser Thr 
                165                 170                 175     


Tyr Tyr Ala Asn Trp Ala Lys Gly Arg Val Thr Ile Ser Val Asp Ser 
            180                 185                 190         


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
        195                 200                 205             


Thr Ala Val Tyr Tyr Cys Ala Arg His Pro Ser Asp Ala Val Tyr Gly 
    210                 215                 220                 


Tyr Ala Asn Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Ser Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            260                 265                 270         


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile 
        275                 280                 285             


Asn Asn Val Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    290                 295                 300                 


Leu Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg 
305                 310                 315                 320 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                325                 330                 335     


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Ser Tyr Gly 
            340                 345                 350         


Asn Tyr Gly Asp Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
        355                 360                 365             


Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 
    370                 375                 380                 


Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Lys Val Ser Gly Phe Ser 
385                 390                 395                 400 


Phe Ser Ser Gly Tyr Asp Met Cys Trp Ile Arg Gln Pro Pro Gly Lys 
                405                 410                 415     


Gly Leu Glu Trp Ile Gly Cys Val Val Ala Gly Ser Val Asp Ile Thr 
            420                 425                 430         


Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Val Thr Ile Ser Val Asp Ser 
        435                 440                 445             


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
    450                 455                 460                 


Thr Ala Val Tyr Tyr Cys Ala Arg Lys Asp Ala Tyr Ser Asp Ala Phe 
465                 470                 475                 480 


Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                485                 490                 495     


Gly Ser Gly Gly Gly Gly Ser Val Val Met Thr Gln Ser Pro Ser Ser 
            500                 505                 510         


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
        515                 520                 525             


Gln Ile Ile Ser Ser Arg Ser Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    530                 535                 540                 


Pro Pro Lys Leu Leu Ile Tyr Gln Ala Ser Lys Leu Ala Ser Gly Val 
545                 550                 555                 560 


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                565                 570                 575     


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Cys 
            580                 585                 590         


Thr Tyr Ile Asp Ser Asn Phe Gly Ala Phe Gly Gly Gly Thr Lys Leu 
        595                 600                 605             


Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
625                 630                 635                 640 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                645                 650                 655     


Ser Gly Phe Ser Phe Ser Ser Ser Tyr Trp Ile Cys Trp Val Arg Gln 
            660                 665                 670         


Ala Pro Gly Lys Gly Leu Glu Trp Val Gly Cys Val Phe Thr Gly Asp 
        675                 680                 685             


Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser 
    690                 695                 700                 


Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
705                 710                 715                 720 


Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Pro Val Ser Val Tyr 
                725                 730                 735     


Tyr Tyr Gly Met Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            740                 745                 750         


Ser 
    


<210>  115
<211>  759
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  115

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Asp Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ile Ile Thr Asp 
                85                  90                  95      


Ile Asp Asn Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 
        115                 120                 125             


Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Lys Val Ser Gly Phe Ser 
    130                 135                 140                 


Phe Asn Asn Asp Tyr Asp Met Cys Trp Ile Arg Gln Pro Pro Gly Lys 
145                 150                 155                 160 


Gly Leu Glu Trp Ile Gly Cys Ile Asp Thr Gly Asp Gly Ser Thr Tyr 
                165                 170                 175     


Tyr Ala Ser Trp Ala Lys Gly Arg Val Thr Ile Ser Val Asp Ser Ser 
            180                 185                 190         


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
        195                 200                 205             


Ala Val Tyr Tyr Cys Ala Arg Glu Ala Ala Ser Ser Ser Gly Tyr Gly 
    210                 215                 220                 


Met Gly Tyr Phe Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            260                 265                 270         


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Ser 
        275                 280                 285             


Val Tyr Asp Asn Asn Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    290                 295                 300                 


Ala Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val 
305                 310                 315                 320 


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                325                 330                 335     


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly 
            340                 345                 350         


Thr Tyr Leu Ser Ser Asn Trp Tyr Trp Ala Phe Gly Thr Gly Thr Lys 
        355                 360                 365             


Val Thr Val Leu Gly Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu 
    370                 375                 380                 


Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys 
385                 390                 395                 400 


Lys Val Ser Gly Phe Ser Phe Ser Ser Gly Tyr Asp Met Cys Trp Ile 
                405                 410                 415     


Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Cys Val Val Ala 
            420                 425                 430         


Gly Ser Val Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Val 
        435                 440                 445             


Thr Ile Ser Val Asp Ser Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser 
    450                 455                 460                 


Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Lys Asp 
465                 470                 475                 480 


Ala Tyr Ser Asp Ala Phe Asn Leu Trp Gly Gln Gly Thr Leu Val Thr 
                485                 490                 495     


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Val Val Met 
            500                 505                 510         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        515                 520                 525             


Ile Thr Cys Gln Ala Ser Gln Ile Ile Ser Ser Arg Ser Ala Trp Tyr 
    530                 535                 540                 


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Gln Ala Ser 
545                 550                 555                 560 


Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                565                 570                 575     


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            580                 585                 590         


Thr Tyr Tyr Cys Gln Cys Thr Tyr Ile Asp Ser Asn Phe Gly Ala Phe 
        595                 600                 605             


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Ser Gly 
    610                 615                 620                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
625                 630                 635                 640 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                645                 650                 655     


Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ser Tyr Trp 
            660                 665                 670         


Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 
        675                 680                 685             


Cys Val Phe Thr Gly Asp Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys 
    690                 695                 700                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
705                 710                 715                 720 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
                725                 730                 735     


Arg Pro Val Ser Val Tyr Tyr Tyr Gly Met Asp Leu Trp Gly Gln Gly 
            740                 745                 750         


Thr Leu Val Thr Val Ser Ser 
        755                 


<210>  116
<211>  759
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  116

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Gly Thr Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Phe Ile Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Asn Phe Tyr Ser Asp Ser 
                85                  90                  95      


Thr Thr Ile Gly Pro Asn Ala Phe Gly Thr Gly Thr Lys Val Thr Val 
            100                 105                 110         


Leu Gly Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro 
        115                 120                 125             


Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Lys Val Ser 
    130                 135                 140                 


Gly Phe Ser Phe Ser Asn Ser Tyr Trp Ile Cys Trp Ile Arg Gln Pro 
145                 150                 155                 160 


Pro Gly Lys Gly Leu Glu Trp Ile Gly Cys Thr Phe Val Gly Ser Ser 
                165                 170                 175     


Asp Ser Thr Tyr Tyr Ala Asn Trp Ala Lys Gly Arg Val Thr Ile Ser 
            180                 185                 190         


Val Asp Ser Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr 
        195                 200                 205             


Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg His Pro Ser Asp Ala 
    210                 215                 220                 


Val Tyr Gly Tyr Ala Asn Asn Leu Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Ile Gln Met Thr Gln Ser Pro Ser Ser 
            260                 265                 270         


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
        275                 280                 285             


Gln Ser Ile Asn Asn Val Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    290                 295                 300                 


Ala Pro Lys Leu Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val 
305                 310                 315                 320 


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                325                 330                 335     


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser 
            340                 345                 350         


Ser Tyr Gly Asn Tyr Gly Asp Phe Gly Thr Gly Thr Lys Val Thr Val 
        355                 360                 365             


Leu Gly Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro 
    370                 375                 380                 


Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Lys Val Ser 
385                 390                 395                 400 


Gly Phe Ser Phe Asn Ser Asp Tyr Trp Ile Tyr Trp Ile Arg Gln Pro 
                405                 410                 415     


Pro Gly Lys Gly Leu Glu Trp Ile Gly Ser Ile Tyr Gly Gly Ser Ser 
            420                 425                 430         


Gly Asn Thr Gln Tyr Ala Ser Trp Ala Gln Gly Arg Val Thr Ile Ser 
        435                 440                 445             


Val Asp Ser Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr 
    450                 455                 460                 


Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Val Asp Tyr 
465                 470                 475                 480 


Gly Gly Ala Thr Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                485                 490                 495     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Met Thr Gln 
            500                 505                 510         


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
        515                 520                 525             


Cys Gln Ser Ser Glu Ser Val Tyr Ser Asn Asn Gln Leu Ser Trp Tyr 
    530                 535                 540                 


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                565                 570                 575     


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            580                 585                 590         


Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Ser Ser Ser Asp Thr Ala Phe 
        595                 600                 605             


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Ser Gly 
    610                 615                 620                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
625                 630                 635                 640 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                645                 650                 655     


Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Asn Ala Met 
            660                 665                 670         


Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly Ile 
        675                 680                 685             


Ile Ser Val Gly Gly Phe Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg 
    690                 695                 700                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met 
705                 710                 715                 720 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp 
                725                 730                 735     


Arg His Gly Gly Asp Ser Ser Gly Ala Phe Tyr Leu Trp Gly Gln Gly 
            740                 745                 750         


Thr Leu Val Thr Val Ser Ser 
        755                 


<210>  117
<211>  758
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  117

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Gly Thr Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Phe Ile Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Asn Phe Tyr Ser Asp Ser 
                85                  90                  95      


Thr Thr Ile Gly Pro Asn Ala Phe Gly Thr Gly Thr Lys Val Thr Val 
            100                 105                 110         


Leu Gly Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro 
        115                 120                 125             


Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Lys Val Ser 
    130                 135                 140                 


Gly Phe Ser Phe Ser Asn Ser Tyr Trp Ile Cys Trp Ile Arg Gln Pro 
145                 150                 155                 160 


Pro Gly Lys Gly Leu Glu Trp Ile Gly Cys Thr Phe Val Gly Ser Ser 
                165                 170                 175     


Asp Ser Thr Tyr Tyr Ala Asn Trp Ala Lys Gly Arg Val Thr Ile Ser 
            180                 185                 190         


Val Asp Ser Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr 
        195                 200                 205             


Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg His Pro Ser Asp Ala 
    210                 215                 220                 


Val Tyr Gly Tyr Ala Asn Asn Leu Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
            260                 265                 270         


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala 
        275                 280                 285             


Ser Gln Ser Ile Asn Asn Val Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
    290                 295                 300                 


Lys Ala Pro Lys Leu Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly 
305                 310                 315                 320 


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                325                 330                 335     


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            340                 345                 350         


Ser Ser Tyr Gly Asn Tyr Gly Asp Phe Gly Thr Gly Thr Lys Val Thr 
        355                 360                 365             


Val Leu Gly Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly 
    370                 375                 380                 


Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Lys Val 
385                 390                 395                 400 


Ser Gly Phe Ser Phe Asn Ser Asp Tyr Trp Ile Tyr Trp Ile Arg Gln 
                405                 410                 415     


Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Ser Ile Tyr Gly Gly Ser 
            420                 425                 430         


Ser Gly Asn Thr Gln Tyr Ala Ser Trp Ala Gln Gly Arg Val Thr Ile 
        435                 440                 445             


Ser Val Asp Ser Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val 
    450                 455                 460                 


Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Val Asp 
465                 470                 475                 480 


Tyr Gly Gly Ala Thr Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val 
                485                 490                 495     


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Val Val Met Thr 
            500                 505                 510         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        515                 520                 525             


Thr Cys Gln Ala Ser Gln Ile Ile Ser Ser Arg Ser Ala Trp Tyr Gln 
    530                 535                 540                 


Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Gln Ala Ser Lys 
545                 550                 555                 560 


Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                565                 570                 575     


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            580                 585                 590         


Tyr Tyr Cys Gln Cys Thr Tyr Ile Asp Ser Asn Phe Gly Ala Phe Gly 
        595                 600                 605             


Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
625                 630                 635                 640 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
                645                 650                 655     


Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ser Tyr Trp Ile 
            660                 665                 670         


Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly Cys 
        675                 680                 685             


Val Phe Thr Gly Asp Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    690                 695                 700                 


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln 
705                 710                 715                 720 


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                725                 730                 735     


Pro Val Ser Val Tyr Tyr Tyr Gly Met Asp Leu Trp Gly Gln Gly Thr 
            740                 745                 750         


Leu Val Thr Val Ser Ser 
        755             


<210>  118
<211>  759
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  118

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Gly Thr Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Phe Ile Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Asn Phe Tyr Ser Asp Ser 
                85                  90                  95      


Thr Thr Ile Gly Pro Asn Ala Phe Gly Thr Gly Thr Lys Val Thr Val 
            100                 105                 110         


Leu Gly Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
        115                 120                 125             


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
    130                 135                 140                 


Gly Phe Ser Phe Ser Asn Ser Tyr Trp Ile Cys Trp Val Arg Gln Ala 
145                 150                 155                 160 


Pro Gly Lys Cys Leu Glu Trp Ile Gly Cys Thr Phe Val Gly Ser Ser 
                165                 170                 175     


Asp Ser Thr Tyr Tyr Ala Asn Trp Ala Lys Gly Arg Phe Thr Ile Ser 
            180                 185                 190         


Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
        195                 200                 205             


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg His Pro Ser Asp Ala 
    210                 215                 220                 


Val Tyr Gly Tyr Ala Asn Asn Leu Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Ile Gln Met Thr Gln Ser Pro Ser Ser 
            260                 265                 270         


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
        275                 280                 285             


Gln Ser Ile Asn Asn Val Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    290                 295                 300                 


Ala Pro Lys Leu Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val 
305                 310                 315                 320 


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                325                 330                 335     


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser 
            340                 345                 350         


Ser Tyr Gly Asn Tyr Gly Asp Phe Gly Cys Gly Thr Lys Val Thr Val 
        355                 360                 365             


Leu Gly Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro 
    370                 375                 380                 


Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Lys Val Ser 
385                 390                 395                 400 


Gly Phe Ser Phe Asn Ser Asp Tyr Trp Ile Tyr Trp Ile Arg Gln Pro 
                405                 410                 415     


Pro Gly Lys Gly Leu Glu Trp Ile Gly Ser Ile Tyr Gly Gly Ser Ser 
            420                 425                 430         


Gly Asn Thr Gln Tyr Ala Ser Trp Ala Gln Gly Arg Val Thr Ile Ser 
        435                 440                 445             


Val Asp Ser Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr 
    450                 455                 460                 


Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Val Asp Tyr 
465                 470                 475                 480 


Gly Gly Ala Thr Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                485                 490                 495     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Met Thr Gln 
            500                 505                 510         


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
        515                 520                 525             


Cys Gln Ser Ser Glu Ser Val Tyr Ser Asn Asn Gln Leu Ser Trp Tyr 
    530                 535                 540                 


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                565                 570                 575     


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            580                 585                 590         


Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Ser Ser Ser Asp Thr Ala Phe 
        595                 600                 605             


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Ser Gly 
    610                 615                 620                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
625                 630                 635                 640 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                645                 650                 655     


Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Asn Ala Met 
            660                 665                 670         


Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly Ile 
        675                 680                 685             


Ile Ser Val Gly Gly Phe Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg 
    690                 695                 700                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met 
705                 710                 715                 720 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp 
                725                 730                 735     


Arg His Gly Gly Asp Ser Ser Gly Ala Phe Tyr Leu Trp Gly Gln Gly 
            740                 745                 750         


Thr Leu Val Thr Val Ser Ser 
        755                 


<210>  119
<211>  759
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  119

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Gly Thr Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Phe Ile Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Asn Phe Tyr Ser Asp Ser 
                85                  90                  95      


Thr Thr Ile Gly Pro Asn Ala Phe Gly Thr Gly Thr Lys Val Thr Val 
            100                 105                 110         


Leu Gly Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
        115                 120                 125             


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
    130                 135                 140                 


Gly Phe Ser Phe Ser Asn Ser Tyr Trp Ile Cys Trp Val Arg Gln Ala 
145                 150                 155                 160 


Pro Gly Lys Cys Leu Glu Trp Ile Gly Cys Thr Phe Val Gly Ser Ser 
                165                 170                 175     


Asp Ser Thr Tyr Tyr Ala Asn Trp Ala Lys Gly Arg Phe Thr Ile Ser 
            180                 185                 190         


Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
        195                 200                 205             


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg His Pro Ser Asp Ala 
    210                 215                 220                 


Val Tyr Gly Tyr Ala Asn Asn Leu Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Ile Gln Met Thr Gln Ser Pro Ser Ser 
            260                 265                 270         


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
        275                 280                 285             


Gln Ser Ile Asn Asn Val Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    290                 295                 300                 


Ala Pro Lys Leu Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val 
305                 310                 315                 320 


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                325                 330                 335     


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser 
            340                 345                 350         


Ser Tyr Gly Asn Tyr Gly Asp Phe Gly Cys Gly Thr Lys Val Thr Val 
        355                 360                 365             


Leu Gly Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
    370                 375                 380                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
385                 390                 395                 400 


Gly Phe Ser Phe Asn Ser Asp Tyr Trp Ile Tyr Trp Val Arg Gln Ala 
                405                 410                 415     


Pro Gly Lys Gly Leu Glu Trp Ile Ala Ser Ile Tyr Gly Gly Ser Ser 
            420                 425                 430         


Gly Asn Thr Gln Tyr Ala Ser Trp Ala Gln Gly Arg Phe Thr Ile Ser 
        435                 440                 445             


Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
    450                 455                 460                 


Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg Gly Tyr Val Asp Tyr 
465                 470                 475                 480 


Gly Gly Ala Thr Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                485                 490                 495     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Met Thr Gln 
            500                 505                 510         


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
        515                 520                 525             


Cys Gln Ser Ser Glu Ser Val Tyr Ser Asn Asn Gln Leu Ser Trp Tyr 
    530                 535                 540                 


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                565                 570                 575     


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            580                 585                 590         


Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Ser Ser Ser Asp Thr Ala Phe 
        595                 600                 605             


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Ser Gly 
    610                 615                 620                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
625                 630                 635                 640 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                645                 650                 655     


Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Asn Ala Met 
            660                 665                 670         


Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly Ile 
        675                 680                 685             


Ile Ser Val Gly Gly Phe Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg 
    690                 695                 700                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met 
705                 710                 715                 720 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp 
                725                 730                 735     


Arg His Gly Gly Asp Ser Ser Gly Ala Phe Tyr Leu Trp Gly Gln Gly 
            740                 745                 750         


Thr Leu Val Thr Val Ser Ser 
        755                 


<210>  120
<211>  759
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  120

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Asn Val 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Ser Tyr Gly Asn Tyr Gly 
                85                  90                  95      


Asp Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Gly 
            100                 105                 110         


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
        115                 120                 125             


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asn Ser 
    130                 135                 140                 


Asp Tyr Trp Ile Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
145                 150                 155                 160 


Trp Ile Ala Ser Ile Tyr Gly Gly Ser Ser Gly Asn Thr Gln Tyr Ala 
                165                 170                 175     


Ser Trp Ala Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
            180                 185                 190         


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
        195                 200                 205             


Tyr Phe Cys Ala Arg Gly Tyr Val Asp Tyr Gly Gly Ala Thr Asp Leu 
    210                 215                 220                 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile 
                245                 250                 255     


Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly Asp Arg 
            260                 265                 270         


Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Gly Thr Tyr Leu Ala 
        275                 280                 285             


Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile Tyr Arg 
    290                 295                 300                 


Ala Phe Ile Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
305                 310                 315                 320 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
                325                 330                 335     


Phe Ala Thr Tyr Tyr Cys Gln Ser Asn Phe Tyr Ser Asp Ser Thr Thr 
            340                 345                 350         


Ile Gly Pro Asn Ala Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
        355                 360                 365             


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    370                 375                 380                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
385                 390                 395                 400 


Ser Phe Ser Asn Ser Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly 
                405                 410                 415     


Lys Cys Leu Glu Trp Ile Gly Cys Thr Phe Val Gly Ser Ser Asp Ser 
            420                 425                 430         


Thr Tyr Tyr Ala Asn Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp 
        435                 440                 445             


Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
    450                 455                 460                 


Asp Thr Ala Val Tyr Tyr Cys Ala Arg His Pro Ser Asp Ala Val Tyr 
465                 470                 475                 480 


Gly Tyr Ala Asn Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                485                 490                 495     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Met Thr Gln 
            500                 505                 510         


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
        515                 520                 525             


Cys Gln Ser Ser Glu Ser Val Tyr Ser Asn Asn Gln Leu Ser Trp Tyr 
    530                 535                 540                 


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                565                 570                 575     


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            580                 585                 590         


Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Ser Ser Ser Asp Thr Ala Phe 
        595                 600                 605             


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Ser Gly 
    610                 615                 620                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
625                 630                 635                 640 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                645                 650                 655     


Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Asn Ala Met 
            660                 665                 670         


Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly Ile 
        675                 680                 685             


Ile Ser Val Gly Gly Phe Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg 
    690                 695                 700                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met 
705                 710                 715                 720 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp 
                725                 730                 735     


Arg His Gly Gly Asp Ser Ser Gly Ala Phe Tyr Leu Trp Gly Gln Gly 
            740                 745                 750         


Thr Leu Val Thr Val Ser Ser 
        755                 


<210>  121
<211>  755
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  121

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Asp Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ile Ile Thr Asp 
                85                  90                  95      


Ile Asp Asn Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
        115                 120                 125             


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser 
    130                 135                 140                 


Phe Ser Asn Ser Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys 
145                 150                 155                 160 


Cys Leu Glu Trp Ile Gly Cys Thr Phe Val Gly Ser Ser Asp Ser Thr 
                165                 170                 175     


Tyr Tyr Ala Asn Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            180                 185                 190         


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
        195                 200                 205             


Thr Ala Val Tyr Tyr Cys Ala Arg His Pro Ser Asp Ala Val Tyr Gly 
    210                 215                 220                 


Tyr Ala Asn Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Ser Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            260                 265                 270         


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile 
        275                 280                 285             


Asn Asn Val Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    290                 295                 300                 


Leu Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg 
305                 310                 315                 320 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                325                 330                 335     


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Ser Tyr Gly 
            340                 345                 350         


Asn Tyr Gly Asp Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly Gly 
        355                 360                 365             


Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 
    370                 375                 380                 


Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Lys Ala Ser Gly Phe Ser 
385                 390                 395                 400 


Phe Ser Ser Gly Tyr Asp Met Cys Trp Val Arg Gln Pro Pro Gly Lys 
                405                 410                 415     


Gly Leu Glu Trp Ile Ala Cys Val Val Ala Gly Ser Val Asp Ile Thr 
            420                 425                 430         


Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Val Thr Ile Ser Lys Asp Ser 
        435                 440                 445             


Ser Lys Asn Gln Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
    450                 455                 460                 


Thr Ala Val Tyr Tyr Cys Ala Arg Lys Asp Ala Tyr Ser Asp Ala Phe 
465                 470                 475                 480 


Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                485                 490                 495     


Gly Ser Gly Gly Gly Gly Ser Ile Gln Met Thr Gln Ser Pro Ser Ser 
            500                 505                 510         


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser 
        515                 520                 525             


Glu Ser Val Tyr Ser Asn Asn Gln Leu Ser Trp Tyr Gln Gln Lys Pro 
    530                 535                 540                 


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asp Leu Ala Ser 
545                 550                 555                 560 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                565                 570                 575     


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            580                 585                 590         


Ala Gly Gly Phe Ser Ser Ser Ser Asp Thr Ala Phe Gly Gly Gly Thr 
        595                 600                 605             


Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    610                 615                 620                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
625                 630                 635                 640 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                645                 650                 655     


Ala Ala Ser Gly Phe Ser Leu Ser Ser Asn Ala Met Gly Trp Val Arg 
            660                 665                 670         


Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly Ile Ile Ser Val Gly 
        675                 680                 685             


Gly Phe Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser 
    690                 695                 700                 


Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
705                 710                 715                 720 


Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Arg His Gly Gly 
                725                 730                 735     


Asp Ser Ser Gly Ala Phe Tyr Leu Trp Gly Gln Gly Thr Leu Val Thr 
            740                 745                 750         


Val Ser Ser 
        755 


<210>  122
<211>  755
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  122

Asp Phe Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Asp Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ile Ile Thr Asp 
                85                  90                  95      


Ile Asp Asn Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
        115                 120                 125             


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser 
    130                 135                 140                 


Phe Ser Asn Ser Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys 
145                 150                 155                 160 


Cys Leu Glu Trp Ile Gly Cys Thr Phe Val Gly Ser Ser Asp Ser Thr 
                165                 170                 175     


Tyr Tyr Ala Asn Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            180                 185                 190         


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
        195                 200                 205             


Thr Ala Val Tyr Tyr Cys Ala Arg His Pro Ser Asp Ala Val Tyr Gly 
    210                 215                 220                 


Tyr Ala Asn Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Ser Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            260                 265                 270         


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile 
        275                 280                 285             


Asn Asn Val Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    290                 295                 300                 


Leu Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg 
305                 310                 315                 320 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                325                 330                 335     


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Ser Tyr Gly 
            340                 345                 350         


Asn Tyr Gly Asp Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly Gly 
        355                 360                 365             


Gly Gly Gly Ser Gln Ser Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 
    370                 375                 380                 


Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Lys Ala Ser Gly Phe Ser 
385                 390                 395                 400 


Phe Ser Ser Gly Tyr Asp Met Cys Trp Val Arg Gln Pro Pro Gly Lys 
                405                 410                 415     


Gly Leu Glu Trp Ile Ala Cys Val Val Ala Gly Ser Val Asp Ile Thr 
            420                 425                 430         


Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Val Thr Ile Ser Lys Asp Ser 
        435                 440                 445             


Ser Lys Asn Gln Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
    450                 455                 460                 


Thr Ala Val Tyr Phe Cys Ala Arg Lys Asp Ala Tyr Ser Asp Ala Phe 
465                 470                 475                 480 


Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                485                 490                 495     


Gly Ser Gly Gly Gly Gly Ser Ile Gln Met Thr Gln Ser Pro Ser Ser 
            500                 505                 510         


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser 
        515                 520                 525             


Glu Ser Val Tyr Ser Asn Asn Gln Leu Ser Trp Tyr Gln Gln Lys Pro 
    530                 535                 540                 


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asp Leu Ala Ser 
545                 550                 555                 560 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                565                 570                 575     


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            580                 585                 590         


Ala Gly Gly Phe Ser Ser Ser Ser Asp Thr Ala Phe Gly Gly Gly Thr 
        595                 600                 605             


Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    610                 615                 620                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
625                 630                 635                 640 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                645                 650                 655     


Ala Ala Ser Gly Phe Ser Leu Ser Ser Asn Ala Met Gly Trp Val Arg 
            660                 665                 670         


Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly Ile Ile Ser Val Gly 
        675                 680                 685             


Gly Phe Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser 
    690                 695                 700                 


Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
705                 710                 715                 720 


Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Arg His Gly Gly 
                725                 730                 735     


Asp Ser Ser Gly Ala Phe Tyr Leu Trp Gly Gln Gly Thr Leu Val Thr 
            740                 745                 750         


Val Ser Ser 
        755 


<210>  123
<211>  755
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  123

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Asn Val 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Ser Tyr Gly Asn Tyr Gly 
                85                  90                  95      


Asp Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Gly 
            100                 105                 110         


Ser Gln Ser Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser 
        115                 120                 125             


Glu Thr Leu Ser Leu Thr Cys Lys Ala Ser Gly Phe Ser Phe Ser Ser 
    130                 135                 140                 


Gly Tyr Asp Met Cys Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
145                 150                 155                 160 


Trp Ile Ala Cys Val Val Ala Gly Ser Val Asp Ile Thr Tyr Tyr Ala 
                165                 170                 175     


Ser Trp Ala Lys Gly Arg Val Thr Ile Ser Lys Asp Ser Ser Lys Asn 
            180                 185                 190         


Gln Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
        195                 200                 205             


Tyr Phe Cys Ala Arg Lys Asp Ala Tyr Ser Asp Ala Phe Asn Leu Trp 
    210                 215                 220                 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Gln 
                245                 250                 255     


Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
            260                 265                 270         


Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Asp Tyr Leu Ala Trp 
        275                 280                 285             


Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile Tyr Lys Ala 
    290                 295                 300                 


Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
305                 310                 315                 320 


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
                325                 330                 335     


Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ile Ile Thr Asp Ile Asp Asn 
            340                 345                 350         


Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Gly 
        355                 360                 365             


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    370                 375                 380                 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asn 
385                 390                 395                 400 


Ser Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu 
                405                 410                 415     


Trp Ile Gly Cys Thr Phe Val Gly Ser Ser Asp Ser Thr Tyr Tyr Ala 
            420                 425                 430         


Asn Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
        435                 440                 445             


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
    450                 455                 460                 


Tyr Tyr Cys Ala Arg His Pro Ser Asp Ala Val Tyr Gly Tyr Ala Asn 
465                 470                 475                 480 


Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                485                 490                 495     


Gly Ser Gly Gly Gly Gly Ser Ile Gln Met Thr Gln Ser Pro Ser Ser 
            500                 505                 510         


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser 
        515                 520                 525             


Glu Ser Val Tyr Ser Asn Asn Gln Leu Ser Trp Tyr Gln Gln Lys Pro 
    530                 535                 540                 


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asp Leu Ala Ser 
545                 550                 555                 560 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                565                 570                 575     


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            580                 585                 590         


Ala Gly Gly Phe Ser Ser Ser Ser Asp Thr Ala Phe Gly Gly Gly Thr 
        595                 600                 605             


Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    610                 615                 620                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
625                 630                 635                 640 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                645                 650                 655     


Ala Ala Ser Gly Phe Ser Leu Ser Ser Asn Ala Met Gly Trp Val Arg 
            660                 665                 670         


Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly Ile Ile Ser Val Gly 
        675                 680                 685             


Gly Phe Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser 
    690                 695                 700                 


Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
705                 710                 715                 720 


Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Arg His Gly Gly 
                725                 730                 735     


Asp Ser Ser Gly Ala Phe Tyr Leu Trp Gly Gln Gly Thr Leu Val Thr 
            740                 745                 750         


Val Ser Ser 
        755 


<210>  124
<211>  755
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  124

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Asn Val 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Ser Tyr Gly Asn Tyr Gly 
                85                  90                  95      


Asp Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Gly 
            100                 105                 110         


Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser 
        115                 120                 125             


Glu Thr Leu Ser Leu Thr Cys Lys Ala Ser Gly Phe Ser Phe Ser Ser 
    130                 135                 140                 


Gly Tyr Asp Met Cys Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
145                 150                 155                 160 


Trp Ile Ala Cys Val Val Ala Gly Ser Val Asp Ile Thr Tyr Tyr Ala 
                165                 170                 175     


Ser Trp Ala Lys Gly Arg Val Thr Ile Ser Lys Asp Ser Ser Lys Asn 
            180                 185                 190         


Gln Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
        195                 200                 205             


Tyr Tyr Cys Ala Arg Lys Asp Ala Tyr Ser Asp Ala Phe Asn Leu Trp 
    210                 215                 220                 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln 
                245                 250                 255     


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
            260                 265                 270         


Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Asp Tyr Leu Ala Trp 
        275                 280                 285             


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala 
    290                 295                 300                 


Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
305                 310                 315                 320 


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
                325                 330                 335     


Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ile Ile Thr Asp Ile Asp Asn 
            340                 345                 350         


Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Gly 
        355                 360                 365             


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    370                 375                 380                 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asn 
385                 390                 395                 400 


Ser Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu 
                405                 410                 415     


Trp Ile Gly Cys Thr Phe Val Gly Ser Ser Asp Ser Thr Tyr Tyr Ala 
            420                 425                 430         


Asn Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
        435                 440                 445             


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
    450                 455                 460                 


Tyr Tyr Cys Ala Arg His Pro Ser Asp Ala Val Tyr Gly Tyr Ala Asn 
465                 470                 475                 480 


Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                485                 490                 495     


Gly Ser Gly Gly Gly Gly Ser Ile Gln Met Thr Gln Ser Pro Ser Ser 
            500                 505                 510         


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser 
        515                 520                 525             


Glu Ser Val Tyr Ser Asn Asn Gln Leu Ser Trp Tyr Gln Gln Lys Pro 
    530                 535                 540                 


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asp Leu Ala Ser 
545                 550                 555                 560 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                565                 570                 575     


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            580                 585                 590         


Ala Gly Gly Phe Ser Ser Ser Ser Asp Thr Ala Phe Gly Gly Gly Thr 
        595                 600                 605             


Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    610                 615                 620                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
625                 630                 635                 640 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                645                 650                 655     


Ala Ala Ser Gly Phe Ser Leu Ser Ser Asn Ala Met Gly Trp Val Arg 
            660                 665                 670         


Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly Ile Ile Ser Val Gly 
        675                 680                 685             


Gly Phe Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser 
    690                 695                 700                 


Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
705                 710                 715                 720 


Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Arg His Gly Gly 
                725                 730                 735     


Asp Ser Ser Gly Ala Phe Tyr Leu Trp Gly Gln Gly Thr Leu Val Thr 
            740                 745                 750         


Val Ser Ser 
        755 


<210>  125
<211>  759
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  125

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Gly Thr Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Phe Ile Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Asn Phe Tyr Ser Asp Ser 
                85                  90                  95      


Thr Thr Ile Gly Pro Asn Ala Phe Gly Thr Gly Thr Lys Val Thr Val 
            100                 105                 110         


Leu Gly Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
        115                 120                 125             


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
    130                 135                 140                 


Gly Phe Ser Phe Ser Ala Asn Tyr Tyr Pro Cys Trp Val Arg Gln Ala 
145                 150                 155                 160 


Pro Gly Lys Gly Leu Glu Trp Ile Gly Cys Ile Tyr Gly Gly Ser Ser 
                165                 170                 175     


Asp Ile Thr Tyr Asp Ala Asn Trp Thr Lys Gly Arg Phe Thr Ile Ser 
            180                 185                 190         


Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
        195                 200                 205             


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Ala Trp Tyr Ser 
    210                 215                 220                 


Gly Trp Gly Gly Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            260                 265                 270         


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser 
        275                 280                 285             


Ile Ser Asn Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    290                 295                 300                 


Lys Leu Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser 
305                 310                 315                 320 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                325                 330                 335     


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr 
            340                 345                 350         


Tyr Gly Asn Asp Gly Asn Ala Phe Gly Thr Gly Thr Lys Val Thr Val 
        355                 360                 365             


Leu Gly Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
    370                 375                 380                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
385                 390                 395                 400 


Gly Phe Ser Phe Asn Ser Asp Tyr Trp Ile Tyr Trp Val Arg Gln Ala 
                405                 410                 415     


Pro Gly Lys Gly Leu Glu Trp Ile Ala Ser Ile Tyr Gly Gly Ser Ser 
            420                 425                 430         


Gly Asn Thr Gln Tyr Ala Ser Trp Ala Gln Gly Arg Phe Thr Ile Ser 
        435                 440                 445             


Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
    450                 455                 460                 


Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg Gly Tyr Val Asp Tyr 
465                 470                 475                 480 


Gly Gly Ala Thr Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                485                 490                 495     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Met Thr Gln 
            500                 505                 510         


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
        515                 520                 525             


Cys Gln Ser Ser Glu Ser Val Tyr Ser Asn Asn Gln Leu Ser Trp Tyr 
    530                 535                 540                 


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                565                 570                 575     


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            580                 585                 590         


Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Ser Ser Ser Asp Thr Ala Phe 
        595                 600                 605             


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Ser Gly 
    610                 615                 620                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
625                 630                 635                 640 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                645                 650                 655     


Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Asn Ala Met 
            660                 665                 670         


Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly Ile 
        675                 680                 685             


Ile Ser Val Gly Gly Phe Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg 
    690                 695                 700                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met 
705                 710                 715                 720 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp 
                725                 730                 735     


Arg His Gly Gly Asp Ser Ser Gly Ala Phe Tyr Leu Trp Gly Gln Gly 
            740                 745                 750         


Thr Leu Val Thr Val Ser Ser 
        755                 


<210>  126
<211>  759
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  126

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Gly Thr Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Phe Ile Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Asn Phe Tyr Ser Asp Ser 
                85                  90                  95      


Thr Thr Ile Gly Pro Asn Ala Phe Gly Thr Gly Thr Lys Val Thr Val 
            100                 105                 110         


Leu Gly Gly Gly Gly Gly Ser Glu Ser Gln Leu Val Glu Ser Gly Gly 
        115                 120                 125             


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
    130                 135                 140                 


Gly Phe Ser Phe Ser Ala Asn Tyr Tyr Pro Cys Trp Val Arg Gln Ala 
145                 150                 155                 160 


Pro Gly Lys Gly Leu Glu Trp Ile Gly Cys Ile Tyr Gly Gly Ser Ser 
                165                 170                 175     


Asp Ile Thr Tyr Asp Ala Asn Trp Thr Lys Gly Arg Phe Thr Ile Ser 
            180                 185                 190         


Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
        195                 200                 205             


Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg Ser Ala Trp Tyr Ser 
    210                 215                 220                 


Gly Trp Gly Gly Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Phe Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            260                 265                 270         


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser 
        275                 280                 285             


Ile Ser Asn Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro 
    290                 295                 300                 


Lys Leu Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser 
305                 310                 315                 320 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                325                 330                 335     


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr 
            340                 345                 350         


Tyr Gly Asn Asp Gly Asn Ala Phe Gly Thr Gly Thr Lys Val Thr Val 
        355                 360                 365             


Leu Gly Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
    370                 375                 380                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
385                 390                 395                 400 


Gly Phe Ser Phe Asn Ser Asp Tyr Trp Ile Tyr Trp Val Arg Gln Ala 
                405                 410                 415     


Pro Gly Lys Gly Leu Glu Trp Ile Ala Ser Ile Tyr Gly Gly Ser Ser 
            420                 425                 430         


Gly Asn Thr Gln Tyr Ala Ser Trp Ala Gln Gly Arg Phe Thr Ile Ser 
        435                 440                 445             


Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
    450                 455                 460                 


Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg Gly Tyr Val Asp Tyr 
465                 470                 475                 480 


Gly Gly Ala Thr Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                485                 490                 495     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Met Thr Gln 
            500                 505                 510         


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
        515                 520                 525             


Cys Gln Ser Ser Glu Ser Val Tyr Ser Asn Asn Gln Leu Ser Trp Tyr 
    530                 535                 540                 


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                565                 570                 575     


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            580                 585                 590         


Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Ser Ser Ser Asp Thr Ala Phe 
        595                 600                 605             


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Ser Gly 
    610                 615                 620                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
625                 630                 635                 640 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                645                 650                 655     


Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Asn Ala Met 
            660                 665                 670         


Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly Ile 
        675                 680                 685             


Ile Ser Val Gly Gly Phe Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg 
    690                 695                 700                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met 
705                 710                 715                 720 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp 
                725                 730                 735     


Arg His Gly Gly Asp Ser Ser Gly Ala Phe Tyr Leu Trp Gly Gln Gly 
            740                 745                 750         


Thr Leu Val Thr Val Ser Ser 
        755                 


<210>  127
<211>  759
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  127

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Gly Thr Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Phe Ile Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Asn Phe Tyr Ser Asp Ser 
                85                  90                  95      


Thr Thr Ile Gly Pro Asn Ala Phe Gly Thr Gly Thr Lys Val Thr Val 
            100                 105                 110         


Leu Gly Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
        115                 120                 125             


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
    130                 135                 140                 


Gly Phe Ser Phe Ser Ala Asn Tyr Tyr Pro Cys Trp Val Arg Gln Ala 
145                 150                 155                 160 


Pro Gly Lys Cys Leu Glu Trp Ile Gly Cys Ile Tyr Gly Gly Ser Ser 
                165                 170                 175     


Asp Ile Thr Tyr Asp Ala Asn Trp Thr Lys Gly Arg Phe Thr Ile Ser 
            180                 185                 190         


Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
        195                 200                 205             


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Ala Trp Tyr Ser 
    210                 215                 220                 


Gly Trp Gly Gly Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            260                 265                 270         


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser 
        275                 280                 285             


Ile Ser Asn Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    290                 295                 300                 


Lys Leu Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser 
305                 310                 315                 320 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                325                 330                 335     


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr 
            340                 345                 350         


Tyr Gly Asn Asp Gly Asn Ala Phe Gly Cys Gly Thr Lys Val Thr Val 
        355                 360                 365             


Leu Gly Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
    370                 375                 380                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
385                 390                 395                 400 


Gly Phe Ser Phe Asn Ser Asp Tyr Trp Ile Tyr Trp Val Arg Gln Ala 
                405                 410                 415     


Pro Gly Lys Gly Leu Glu Trp Ile Ala Ser Ile Tyr Gly Gly Ser Ser 
            420                 425                 430         


Gly Asn Thr Gln Tyr Ala Ser Trp Ala Gln Gly Arg Phe Thr Ile Ser 
        435                 440                 445             


Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
    450                 455                 460                 


Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg Gly Tyr Val Asp Tyr 
465                 470                 475                 480 


Gly Gly Ala Thr Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                485                 490                 495     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Met Thr Gln 
            500                 505                 510         


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
        515                 520                 525             


Cys Gln Ser Ser Glu Ser Val Tyr Ser Asn Asn Gln Leu Ser Trp Tyr 
    530                 535                 540                 


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                565                 570                 575     


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            580                 585                 590         


Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Ser Ser Ser Asp Thr Ala Phe 
        595                 600                 605             


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Ser Gly 
    610                 615                 620                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
625                 630                 635                 640 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                645                 650                 655     


Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Asn Ala Met 
            660                 665                 670         


Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly Ile 
        675                 680                 685             


Ile Ser Val Gly Gly Phe Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg 
    690                 695                 700                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met 
705                 710                 715                 720 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp 
                725                 730                 735     


Arg His Gly Gly Asp Ser Ser Gly Ala Phe Tyr Leu Trp Gly Gln Gly 
            740                 745                 750         


Thr Leu Val Thr Val Ser Ser 
        755                 


<210>  128
<211>  761
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  128

Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
1               5                   10                  15      


Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Gly Thr Tyr Leu Ala Trp 
            20                  25                  30          


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Arg Ala 
        35                  40                  45              


Phe Ile Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    50                  55                  60                  


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
65                  70                  75                  80  


Ala Thr Tyr Tyr Cys Gln Ser Asn Phe Tyr Ser Asp Ser Thr Thr Ile 
                85                  90                  95      


Gly Pro Asn Ala Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
        115                 120                 125             


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser 
    130                 135                 140                 


Phe Ser Asn Ser Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys 
145                 150                 155                 160 


Cys Leu Glu Trp Ile Gly Cys Thr Phe Val Gly Ser Ser Asp Ser Thr 
                165                 170                 175     


Tyr Tyr Ala Asn Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            180                 185                 190         


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
        195                 200                 205             


Thr Ala Val Tyr Tyr Cys Ala Arg His Pro Ser Asp Ala Val Tyr Gly 
    210                 215                 220                 


Tyr Ala Asn Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Ser Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            260                 265                 270         


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile 
        275                 280                 285             


Asn Asn Val Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    290                 295                 300                 


Leu Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg 
305                 310                 315                 320 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                325                 330                 335     


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Ser Tyr Gly 
            340                 345                 350         


Asn Tyr Gly Asp Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly Gly 
        355                 360                 365             


Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 
    370                 375                 380                 


Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Lys Val Ser Gly Phe Ser 
385                 390                 395                 400 


Phe Asn Ser Asp Tyr Trp Ile Tyr Trp Ile Arg Gln Pro Pro Gly Lys 
                405                 410                 415     


Gly Leu Glu Trp Ile Gly Ser Ile Tyr Gly Gly Ser Ser Gly Asn Thr 
            420                 425                 430         


Gln Tyr Ala Ser Trp Ala Gln Gly Arg Val Thr Ile Ser Val Asp Ser 
        435                 440                 445             


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
    450                 455                 460                 


Thr Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Val Asp Tyr Gly Gly Ala 
465                 470                 475                 480 


Thr Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                485                 490                 495     


Gly Gly Ser Gly Gly Gly Gly Ser Val Val Met Thr Gln Ser Pro Ser 
            500                 505                 510         


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala 
        515                 520                 525             


Ser Gln Ile Ile Ser Ser Arg Ser Ala Trp Tyr Gln Gln Lys Pro Gly 
    530                 535                 540                 


Gln Pro Pro Lys Leu Leu Ile Tyr Gln Ala Ser Lys Leu Ala Ser Gly 
545                 550                 555                 560 


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                565                 570                 575     


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            580                 585                 590         


Cys Thr Tyr Ile Asp Ser Asn Phe Gly Ala Phe Gly Gly Gly Thr Lys 
        595                 600                 605             


Leu Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    610                 615                 620                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
625                 630                 635                 640 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
                645                 650                 655     


Ala Ser Gly Phe Ser Phe Ser Ser Ser Tyr Trp Ile Cys Trp Val Arg 
            660                 665                 670         


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly Cys Val Phe Thr Gly 
        675                 680                 685             


Asp Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile 
    690                 695                 700                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
705                 710                 715                 720 


Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Pro Val Ser Val 
                725                 730                 735     


Tyr Tyr Tyr Gly Met Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val 
            740                 745                 750         


Ser Ser Leu Glu Ser Arg Gly Pro Val 
        755                 760     


<210>  129
<211>  757
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  129

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Gly Thr Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Phe Ile Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Asn Phe Tyr Ser Asp Ser 
                85                  90                  95      


Thr Thr Ile Gly Pro Asn Ala Phe Gly Thr Gly Thr Lys Val Thr Val 
            100                 105                 110         


Leu Gly Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
        115                 120                 125             


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
    130                 135                 140                 


Gly Phe Ser Phe Ser Asn Ser Tyr Trp Ile Cys Trp Val Arg Gln Ala 
145                 150                 155                 160 


Pro Gly Lys Cys Leu Glu Trp Ile Gly Cys Thr Phe Val Gly Ser Ser 
                165                 170                 175     


Asp Ser Thr Tyr Tyr Ala Asn Trp Ala Lys Gly Arg Phe Thr Ile Ser 
            180                 185                 190         


Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
        195                 200                 205             


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg His Pro Ser Asp Ala 
    210                 215                 220                 


Val Tyr Gly Tyr Ala Asn Asn Leu Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Ile Gln Met Thr Gln Ser Pro Ser Ser 
            260                 265                 270         


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
        275                 280                 285             


Gln Ser Ile Asn Asn Val Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    290                 295                 300                 


Ala Pro Lys Leu Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val 
305                 310                 315                 320 


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                325                 330                 335     


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser 
            340                 345                 350         


Ser Tyr Gly Asn Tyr Gly Asp Phe Gly Cys Gly Thr Lys Val Thr Val 
        355                 360                 365             


Leu Gly Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro 
    370                 375                 380                 


Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Lys Val Ser 
385                 390                 395                 400 


Gly Phe Ser Phe Asn Ser Asp Tyr Trp Ile Tyr Trp Ile Arg Gln Pro 
                405                 410                 415     


Pro Gly Lys Gly Leu Glu Trp Ile Gly Ser Ile Tyr Gly Gly Ser Ser 
            420                 425                 430         


Gly Asn Thr Gln Tyr Ala Ser Trp Ala Gln Gly Arg Val Thr Ile Ser 
        435                 440                 445             


Val Asp Ser Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr 
    450                 455                 460                 


Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Val Asp Tyr 
465                 470                 475                 480 


Gly Gly Ala Thr Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                485                 490                 495     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Val Val Met Thr Gln 
            500                 505                 510         


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
        515                 520                 525             


Cys Gln Ala Ser Gln Ile Ile Ser Ser Arg Ser Ala Trp Tyr Gln Gln 
    530                 535                 540                 


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Gln Ala Ser Lys Leu 
545                 550                 555                 560 


Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                565                 570                 575     


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
            580                 585                 590         


Tyr Cys Gln Cys Thr Tyr Ile Asp Ser Asn Phe Gly Ala Phe Gly Gly 
        595                 600                 605             


Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
625                 630                 635                 640 


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
                645                 650                 655     


Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ser Tyr Trp Ile Cys 
            660                 665                 670         


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly Cys Val 
        675                 680                 685             


Phe Thr Gly Asp Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg 
    690                 695                 700                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met 
705                 710                 715                 720 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Pro 
                725                 730                 735     


Val Ser Val Tyr Tyr Tyr Gly Met Asp Leu Trp Gly Gln Gly Thr Leu 
            740                 745                 750         


Val Thr Val Ser Ser 
        755         


<210>  130
<211>  757
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  130

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Gly Thr Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Phe Ile Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Asn Phe Tyr Ser Asp Ser 
                85                  90                  95      


Thr Thr Ile Gly Pro Asn Ala Phe Gly Thr Gly Thr Lys Val Thr Val 
            100                 105                 110         


Leu Gly Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
        115                 120                 125             


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
    130                 135                 140                 


Gly Phe Ser Phe Ser Ala Asn Tyr Tyr Pro Cys Trp Val Arg Gln Ala 
145                 150                 155                 160 


Pro Gly Lys Gly Leu Glu Trp Ile Gly Cys Ile Tyr Gly Gly Ser Ser 
                165                 170                 175     


Asp Ile Thr Tyr Asp Ala Asn Trp Thr Lys Gly Arg Phe Thr Ile Ser 
            180                 185                 190         


Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
        195                 200                 205             


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Ala Trp Tyr Ser 
    210                 215                 220                 


Gly Trp Gly Gly Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            260                 265                 270         


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser 
        275                 280                 285             


Ile Ser Asn Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    290                 295                 300                 


Lys Leu Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser 
305                 310                 315                 320 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                325                 330                 335     


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr 
            340                 345                 350         


Tyr Gly Asn Asp Gly Asn Ala Phe Gly Thr Gly Thr Lys Val Thr Val 
        355                 360                 365             


Leu Gly Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
    370                 375                 380                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
385                 390                 395                 400 


Gly Phe Ser Phe Asn Ser Asp Tyr Trp Ile Tyr Trp Val Arg Gln Ala 
                405                 410                 415     


Pro Gly Lys Gly Leu Glu Trp Ile Ala Ser Ile Tyr Gly Gly Ser Ser 
            420                 425                 430         


Gly Asn Thr Gln Tyr Ala Ser Trp Ala Gln Gly Arg Phe Thr Ile Ser 
        435                 440                 445             


Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
    450                 455                 460                 


Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg Gly Tyr Val Asp Tyr 
465                 470                 475                 480 


Gly Gly Ala Thr Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                485                 490                 495     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Val Val Met Thr Gln 
            500                 505                 510         


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
        515                 520                 525             


Cys Gln Ala Ser Gln Ile Ile Ser Ser Arg Ser Ala Trp Tyr Gln Gln 
    530                 535                 540                 


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Gln Ala Ser Lys Leu 
545                 550                 555                 560 


Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                565                 570                 575     


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
            580                 585                 590         


Tyr Cys Gln Cys Thr Tyr Ile Asp Ser Asn Phe Gly Ala Phe Gly Gly 
        595                 600                 605             


Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
625                 630                 635                 640 


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
                645                 650                 655     


Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ser Tyr Trp Ile Cys 
            660                 665                 670         


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly Cys Val 
        675                 680                 685             


Phe Thr Gly Asp Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg 
    690                 695                 700                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met 
705                 710                 715                 720 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Pro 
                725                 730                 735     


Val Ser Val Tyr Tyr Tyr Gly Met Asp Leu Trp Gly Gln Gly Thr Leu 
            740                 745                 750         


Val Thr Val Ser Ser 
        755         


<210>  131
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  131

Gly Phe Ser Leu Ser Ser Tyr Asp Met Ser 
1               5                   10  


<210>  132
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  132

Ala Ser Tyr Ala Ser Gly Pro Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  133
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  133

Arg Gly Gly Trp Thr Gly Thr Ser His Ser Asn Ile 
1               5                   10          


<210>  134
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  134

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Ala Trp Ile 
        35                  40                  45              


Gly Ala Ser Tyr Ala Ser Gly Pro Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Gly Trp Thr Gly Thr Ser His Ser Asn Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  135
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  135

Gln Ser Ser Gln Ser Val Phe Ser Asn Asn Tyr Leu Ala 
1               5                   10              


<210>  136
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  136

Ser Ala Ser Thr Leu Ala Ser 
1               5           


<210>  137
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  137

Leu Gly Ser Tyr Ala Cys Ser Ser Ala Asp Cys Tyr Val 
1               5                   10              


<210>  138
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  138

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Phe Ser Asn 
            20                  25                  30          


Asn Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Arg 
        35                  40                  45              


Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Ala Cys 
                85                  90                  95      


Ser Ser Ala Asp Cys Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val 
            100                 105                 110         


Leu Gly 
        


<210>  139
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  139

Gly Ile Ser Val Ser Asn Asp Tyr Tyr Met Cys 
1               5                   10      


<210>  140
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  140

Cys Ile Ser Thr Tyr Ile Gly Asn Thr His Tyr Ala Ser Trp Ala Lys 
1               5                   10                  15      


Gly 
    


<210>  141
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  141

Lys Asn Ala Gly Tyr Pro Gly Tyr Arg Tyr Ala Ile Asp Leu 
1               5                   10                  


<210>  142
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  142

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Ser Val Ser Asn Asp 
            20                  25                  30          


Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Ile Ser Thr Tyr Ile Gly Asn Thr His Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Lys Asn Ala Gly Tyr Pro Gly Tyr Arg Tyr Ala Ile Asp Leu 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  143
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  143

Gln Ala Ser Glu Ser Ile Gly Asn Tyr Leu Ala 
1               5                   10      


<210>  144
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  144

Ser Ala Ser Thr Leu Ala Ser 
1               5           


<210>  145
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  145

Gln Ser Thr Asp Tyr Gly Asp Ser Tyr Ile 
1               5                   10  


<210>  146
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  146

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Gly Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Thr Asp Tyr Gly Asp Ser 
                85                  90                  95      


Tyr Ile Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 


<210>  147
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  147

Gly Phe Ser Leu Ser Ser Tyr Ala Met Gly 
1               5                   10  


<210>  148
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  148

Tyr Ile Ser Thr Ile Asn Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  149
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  149

Arg Glu Ile Arg Ser Gly Trp Val Asp Tyr Gly Phe Ser Ile 
1               5                   10                  


<210>  150
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  150

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Ser Thr Ile Asn Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Ile Arg Ser Gly Trp Val Asp Tyr Gly Phe Ser Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  151
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  151

Tyr Ile Ser Thr Ile Ala Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  152
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  152

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Ser Thr Ile Ala Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Ile Arg Ser Gly Trp Val Asp Tyr Gly Phe Ser Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  153
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  153

Gln Ala Ser Gln Asn Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  154
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  154

Asp Ala Ser Asp Leu Ala Ser 
1               5           


<210>  155
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  155

Gln Gln Val Arg Ser Ser Ser Asp Ile Asp Asn Pro 
1               5                   10          


<210>  156
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  156

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Arg Ser Ser Ser Asp 
                85                  90                  95      


Ile Asp Asn Pro Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110     


<210>  157
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  157

Gly Phe Ser Leu Ser Ser Tyr Ala Met Gly 
1               5                   10  


<210>  158
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  158

Tyr Ile Ser Lys Ile Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  159
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  159

Arg Gly Ser Ser Ser Gly Gly Tyr Leu Asp Asp Gly Phe Asp Pro 
1               5                   10                  15  


<210>  160
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  160

Gln Ser Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Tyr Ile Ser Lys Ile Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Ser Ser Ser Gly Gly Tyr Leu Asp Asp Gly Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  161
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  161

Gln Ala Ser Gln Ser Ile Ser Asn Tyr Leu Ala 
1               5                   10      


<210>  162
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  162

Asp Ala Ser Asp Leu Ala Ser 
1               5           


<210>  163
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  163

Gln Gln Val Tyr Asp Ser Asn Asn Val Glu Asn Val 
1               5                   10          


<210>  164
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  164

Ala Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Phe Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Tyr Asp Ser Asn Asn 
                85                  90                  95      


Val Glu Asn Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110     


<210>  165
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  165

Gly Phe Asn Ile Lys Asp Thr Tyr Ile His 
1               5                   10  


<210>  166
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  166

Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  167
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  167

Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  168
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  168

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  169
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  169

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  170
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  170

Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala 
1               5                   10      


<210>  171
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  171

Ser Ala Ser Phe Leu Tyr Ser 
1               5           


<210>  172
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  172

Gln Gln His Tyr Thr Thr Pro Pro Thr 
1               5                   


<210>  173
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  173

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105             


<210>  174
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  174

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105             


<210>  175
<211>  756
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  175

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ile Ile Ser Ser Arg 
            20                  25                  30          


Ser Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gln Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Cys Thr Tyr Ile Asp Ser Asn 
                85                  90                  95      


Phe Gly Ala Phe Gly Cys Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
        115                 120                 125             


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu 
    130                 135                 140                 


Ser Ser Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
145                 150                 155                 160 


Ala Trp Ile Gly Ala Ser Tyr Ala Ser Gly Pro Thr Tyr Tyr Ala Ser 
                165                 170                 175     


Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
            180                 185                 190         


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr 
        195                 200                 205             


Phe Cys Ala Arg Gly Gly Trp Thr Gly Thr Ser His Ser Asn Ile Trp 
    210                 215                 220                 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
                245                 250                 255     


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
            260                 265                 270         


Val Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Phe Ser Asn Asn Tyr 
        275                 280                 285             


Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Arg Leu Ile 
    290                 295                 300                 


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
305                 310                 315                 320 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
                325                 330                 335     


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Ala Cys Ser Ser 
            340                 345                 350         


Ala Asp Cys Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
        355                 360                 365             


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    370                 375                 380                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
385                 390                 395                 400 


Ser Phe Ser Ser Ser Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly 
                405                 410                 415     


Lys Cys Leu Glu Trp Val Gly Cys Val Phe Thr Gly Asp Gly Thr Thr 
            420                 425                 430         


Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        435                 440                 445             


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    450                 455                 460                 


Thr Ala Thr Tyr Phe Cys Ala Arg Pro Val Ser Val Tyr Tyr Tyr Gly 
465                 470                 475                 480 


Met Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                485                 490                 495     


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
            500                 505                 510         


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln 
        515                 520                 525             


Ala Ser Glu Ser Ile Gly Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 
    530                 535                 540                 


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ser 
545                 550                 555                 560 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                565                 570                 575     


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            580                 585                 590         


Gln Ser Thr Asp Tyr Gly Asp Ser Tyr Ile Phe Gly Thr Gly Thr Lys 
        595                 600                 605             


Val Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    610                 615                 620                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
625                 630                 635                 640 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
                645                 650                 655     


Ala Ser Gly Ile Ser Val Ser Asn Asp Tyr Tyr Met Cys Trp Val Arg 
            660                 665                 670         


Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Cys Ile Ser Thr Tyr 
        675                 680                 685             


Ile Gly Asn Thr His Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile 
    690                 695                 700                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
705                 710                 715                 720 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Asn Ala Gly Tyr 
                725                 730                 735     


Pro Gly Tyr Arg Tyr Ala Ile Asp Leu Trp Gly Gln Gly Thr Leu Val 
            740                 745                 750         


Thr Val Ser Ser 
        755     


<210>  176
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  176

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Arg Ser Ser Ser Asp 
                85                  90                  95      


Ile Asp Asn Pro Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu 
145                 150                 155                 160 


Ser Ser Tyr Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Ile Gly Tyr Ile Ser Thr Ile Asn Asn Thr Tyr Tyr Ala Ser 
            180                 185                 190         


Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
        195                 200                 205             


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
    210                 215                 220                 


Tyr Cys Ala Arg Glu Ile Arg Ser Gly Trp Val Asp Tyr Gly Phe Ser 
225                 230                 235                 240 


Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            260                 265                 270         


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        275                 280                 285             


Phe Ser Leu Ser Ser Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly 
    290                 295                 300                 


Lys Gly Leu Ala Trp Ile Gly Ala Ser Tyr Ala Ser Gly Pro Thr Tyr 
305                 310                 315                 320 


Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                325                 330                 335     


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            340                 345                 350         


Ala Thr Tyr Phe Cys Ala Arg Gly Gly Trp Thr Gly Thr Ser His Ser 
        355                 360                 365             


Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
385                 390                 395                 400 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                405                 410                 415     


Ser Phe Ser Ser Ser Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly 
            420                 425                 430         


Lys Cys Leu Glu Trp Val Gly Cys Val Phe Thr Gly Asp Gly Thr Thr 
        435                 440                 445             


Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    450                 455                 460                 


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
465                 470                 475                 480 


Thr Ala Thr Tyr Phe Cys Ala Arg Pro Val Ser Val Tyr Tyr Tyr Gly 
                485                 490                 495     


Met Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            500                 505                 510 


<210>  177
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  177

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Arg Ser Ser Ser Asp 
                85                  90                  95      


Ile Asp Asn Pro Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu 
145                 150                 155                 160 


Ser Ser Tyr Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Ile Gly Tyr Ile Ser Thr Ile Asn Asn Thr Tyr Tyr Ala Ser 
            180                 185                 190         


Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
        195                 200                 205             


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
    210                 215                 220                 


Tyr Cys Ala Arg Glu Ile Arg Ser Gly Trp Val Asp Tyr Gly Phe Ser 
225                 230                 235                 240 


Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Ser 
            260                 265                 270         


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
        275                 280                 285             


Gln Ile Ile Ser Ser Arg Ser Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    290                 295                 300                 


Pro Pro Lys Leu Leu Ile Tyr Gln Ala Ser Lys Leu Ala Ser Gly Val 
305                 310                 315                 320 


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                325                 330                 335     


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Cys 
            340                 345                 350         


Thr Tyr Ile Asp Ser Asn Phe Gly Ala Phe Gly Cys Gly Thr Lys Leu 
        355                 360                 365             


Thr Val Leu Gly Gly Gly Ser Gly Gly Ser Asp Ile Gln Met Thr Gln 
    370                 375                 380                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
385                 390                 395                 400 


Cys Gln Ser Ser Gln Ser Val Phe Ser Asn Asn Tyr Leu Ala Trp Phe 
                405                 410                 415     


Gln Gln Lys Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr Ser Ala Ser 
            420                 425                 430         


Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        435                 440                 445             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    450                 455                 460                 


Thr Tyr Tyr Cys Leu Gly Ser Tyr Ala Cys Ser Ser Ala Asp Cys Tyr 
465                 470                 475                 480 


Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
                485                 490         


<210>  178
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  178

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Arg Ser Ser Ser Asp 
                85                  90                  95      


Ile Asp Asn Pro Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu 
145                 150                 155                 160 


Ser Ser Tyr Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Ile Gly Tyr Ile Ser Thr Ile Ala Asn Thr Tyr Tyr Ala Ser 
            180                 185                 190         


Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
        195                 200                 205             


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
    210                 215                 220                 


Tyr Cys Ala Arg Glu Ile Arg Ser Gly Trp Val Asp Tyr Gly Phe Ser 
225                 230                 235                 240 


Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            260                 265                 270         


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        275                 280                 285             


Phe Ser Leu Ser Ser Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly 
    290                 295                 300                 


Lys Gly Leu Ala Trp Ile Gly Ala Ser Tyr Ala Ser Gly Pro Thr Tyr 
305                 310                 315                 320 


Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                325                 330                 335     


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            340                 345                 350         


Ala Thr Tyr Phe Cys Ala Arg Gly Gly Trp Thr Gly Thr Ser His Ser 
        355                 360                 365             


Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
385                 390                 395                 400 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                405                 410                 415     


Ser Phe Ser Ser Ser Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly 
            420                 425                 430         


Lys Cys Leu Glu Trp Val Gly Cys Val Phe Thr Gly Asp Gly Thr Thr 
        435                 440                 445             


Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    450                 455                 460                 


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
465                 470                 475                 480 


Thr Ala Thr Tyr Phe Cys Ala Arg Pro Val Ser Val Tyr Tyr Tyr Gly 
                485                 490                 495     


Met Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            500                 505                 510 


<210>  179
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  179

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Arg Ser Ser Ser Asp 
                85                  90                  95      


Ile Asp Asn Pro Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu 
145                 150                 155                 160 


Ser Ser Tyr Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Ile Gly Tyr Ile Ser Thr Ile Ala Asn Thr Tyr Tyr Ala Ser 
            180                 185                 190         


Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
        195                 200                 205             


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
    210                 215                 220                 


Tyr Cys Ala Arg Glu Ile Arg Ser Gly Trp Val Asp Tyr Gly Phe Ser 
225                 230                 235                 240 


Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Ser 
            260                 265                 270         


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
        275                 280                 285             


Gln Ile Ile Ser Ser Arg Ser Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    290                 295                 300                 


Pro Pro Lys Leu Leu Ile Tyr Gln Ala Ser Lys Leu Ala Ser Gly Val 
305                 310                 315                 320 


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                325                 330                 335     


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Cys 
            340                 345                 350         


Thr Tyr Ile Asp Ser Asn Phe Gly Ala Phe Gly Cys Gly Thr Lys Leu 
        355                 360                 365             


Thr Val Leu Gly Gly Gly Ser Gly Gly Ser Asp Ile Gln Met Thr Gln 
    370                 375                 380                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
385                 390                 395                 400 


Cys Gln Ser Ser Gln Ser Val Phe Ser Asn Asn Tyr Leu Ala Trp Phe 
                405                 410                 415     


Gln Gln Lys Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr Ser Ala Ser 
            420                 425                 430         


Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        435                 440                 445             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    450                 455                 460                 


Thr Tyr Tyr Cys Leu Gly Ser Tyr Ala Cys Ser Ser Ala Asp Cys Tyr 
465                 470                 475                 480 


Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
                485                 490         


<210>  180
<211>  752
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  180

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Phe Ser Asn 
            20                  25                  30          


Asn Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Arg 
        35                  40                  45              


Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Ala Cys 
                85                  90                  95      


Ser Ser Ala Asp Cys Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val 
            100                 105                 110         


Leu Gly Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
        115                 120                 125             


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
    130                 135                 140                 


Gly Phe Ser Leu Ser Ser Asn Ala Met Gly Trp Val Arg Gln Ala Pro 
145                 150                 155                 160 


Gly Lys Gly Leu Glu Tyr Ile Gly Ile Ile Ser Val Gly Gly Phe Thr 
                165                 170                 175     


Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            180                 185                 190         


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
        195                 200                 205             


Thr Ala Thr Tyr Phe Cys Ala Arg Asp Arg His Gly Gly Asp Ser Ser 
    210                 215                 220                 


Gly Ala Phe Tyr Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Ser Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            260                 265                 270         


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Glu Ser Val 
        275                 280                 285             


Tyr Ser Asn Asn Gln Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro 
    290                 295                 300                 


Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro 
305                 310                 315                 320 


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                325                 330                 335     


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Gly 
            340                 345                 350         


Phe Ser Ser Ser Ser Asp Thr Ala Phe Gly Gly Gly Thr Lys Leu Thr 
        355                 360                 365             


Val Leu Gly Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
    370                 375                 380                 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
385                 390                 395                 400 


Ser Gly Phe Ser Leu Ser Ser Tyr Asp Met Ser Trp Val Arg Gln Ala 
                405                 410                 415     


Pro Gly Lys Gly Leu Ala Trp Ile Gly Ala Ser Tyr Ala Ser Gly Pro 
            420                 425                 430         


Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp 
        435                 440                 445             


Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
    450                 455                 460                 


Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Gly Trp Thr Gly Thr Ser 
465                 470                 475                 480 


His Ser Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                485                 490                 495     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Met Thr Gln Ser Pro 
            500                 505                 510         


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
        515                 520                 525             


Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro 
    530                 535                 540                 


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser 
545                 550                 555                 560 


Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr 
                565                 570                 575     


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            580                 585                 590         


Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Cys Gly Thr Lys Leu 
        595                 600                 605             


Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
625                 630                 635                 640 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                645                 650                 655     


Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala 
            660                 665                 670         


Pro Gly Lys Cys Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly 
        675                 680                 685             


Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala 
    690                 695                 700                 


Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala 
705                 710                 715                 720 


Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe 
                725                 730                 735     


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            740                 745                 750         


<210>  181
<211>  752
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-based sequence

<400>  181

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Phe Ser Asn 
            20                  25                  30          


Asn Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Arg 
        35                  40                  45              


Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Ala Cys 
                85                  90                  95      


Ser Ser Ala Asp Cys Tyr Val Phe Gly Cys Gly Thr Lys Val Thr Val 
            100                 105                 110         


Leu Gly Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
        115                 120                 125             


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
    130                 135                 140                 


Gly Phe Ser Leu Ser Ser Asn Ala Met Gly Trp Val Arg Gln Ala Pro 
145                 150                 155                 160 


Gly Lys Gly Leu Glu Tyr Ile Gly Ile Ile Ser Val Gly Gly Phe Thr 
                165                 170                 175     


Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            180                 185                 190         


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
        195                 200                 205             


Thr Ala Thr Tyr Phe Cys Ala Arg Asp Arg His Gly Gly Asp Ser Ser 
    210                 215                 220                 


Gly Ala Phe Tyr Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Ser Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            260                 265                 270         


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Glu Ser Val 
        275                 280                 285             


Tyr Ser Asn Asn Gln Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro 
    290                 295                 300                 


Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro 
305                 310                 315                 320 


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                325                 330                 335     


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Gly 
            340                 345                 350         


Phe Ser Ser Ser Ser Asp Thr Ala Phe Gly Gly Gly Thr Lys Leu Thr 
        355                 360                 365             


Val Leu Gly Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
    370                 375                 380                 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
385                 390                 395                 400 


Ser Gly Phe Ser Leu Ser Ser Tyr Asp Met Ser Trp Val Arg Gln Ala 
                405                 410                 415     


Pro Gly Lys Cys Leu Ala Trp Ile Gly Ala Ser Tyr Ala Ser Gly Pro 
            420                 425                 430         


Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp 
        435                 440                 445             


Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
    450                 455                 460                 


Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Gly Trp Thr Gly Thr Ser 
465                 470                 475                 480 


His Ser Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                485                 490                 495     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Met Thr Gln Ser Pro 
            500                 505                 510         


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
        515                 520                 525             


Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro 
    530                 535                 540                 


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser 
545                 550                 555                 560 


Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr 
                565                 570                 575     


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            580                 585                 590         


Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Cys Gly Thr Lys Leu 
        595                 600                 605             


Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
625                 630                 635                 640 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                645                 650                 655     


Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala 
            660                 665                 670         


Pro Gly Lys Cys Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly 
        675                 680                 685             


Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala 
    690                 695                 700                 


Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala 
705                 710                 715                 720 


Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe 
                725                 730                 735     


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            740                 745                 750         


<210>  182
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  182

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Arg Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Ala Trp Ile 
        35                  40                  45              


Gly Ala Ser Tyr Ala Ser Gly Pro Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Gly Trp Thr Gly Thr Ser His Ser Asn Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  183
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  183

Gly Phe Ser Leu Ser Ser Tyr Ala Met Asn 
1               5                   10  


<210>  184
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  184

His Ile Asn Ala Gly Asp Ile Ala Tyr Tyr Ala Thr Trp Ala Lys Gly 
1               5                   10                  15      


<210>  185
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  185

Arg Gly Ala Gly Gly Phe Ser Thr Gly Pro Phe Lys Leu 
1               5                   10              


<210>  186
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  186

Gln Ala Ser Glu Ser Ile Asn Ser Arg Leu Ala 
1               5                   10      


<210>  187
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  187

Asp Ala Ser Asp Leu Thr Ser 
1               5           


<210>  188
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  188

Gln Gly Tyr Gly Gly Ser Ser Thr Thr Thr 
1               5                   10  


<210>  189
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  189

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Arg Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly His Ile Asn Ala Gly Asp Ile Ala Tyr Tyr Ala Thr Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Ala Gly Gly Phe Ser Thr Gly Pro Phe Lys Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  190
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  190

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly His Ile Asn Ala Gly Asp Ile Ala Tyr Tyr Ala Thr Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Ala Gly Gly Phe Ser Thr Gly Pro Phe Lys Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  191
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  191

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Arg Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly His Ile Asn Ala Gly Asp Ile Ala Tyr Tyr Ala Thr Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Ala Gly Gly Phe Ser Thr Gly Pro Phe Lys Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  192
<211>  109
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  192

Ala Phe Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Asn Ser Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Thr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Gly Gly Ser Ser Thr 
                85                  90                  95      


Thr Thr Phe Gly Cys Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 


<210>  193
<211>  109
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  193

Ala Phe Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Asn Ser Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Thr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Gly Gly Ser Ser Thr 
                85                  90                  95      


Thr Thr Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 


<210>  194
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  194

Gln Ser Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Tyr Ile 
        35                  40                  45              


Gly Tyr Ile Ser Lys Ile Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Ser Ser Ser Gly Gly Tyr Leu Asp Asp Gly Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  195
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  195

Gln Ser Gln Leu Val Glu Ser Gly Gly Gly Arg Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Tyr Ile 
        35                  40                  45              


Gly Tyr Ile Ser Lys Ile Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Ser Ser Ser Gly Gly Tyr Leu Asp Asp Gly Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  196
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  196

Ala Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Arg Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Phe Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Tyr Asp Ser Asn Asn 
                85                  90                  95      


Val Glu Asn Val Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110     


<210>  197
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  197

Gly Phe Ser Phe Ser Thr Thr Tyr Tyr Met Cys 
1               5                   10      


<210>  198
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  198

Cys Thr Asn Thr Ala Ser Ser Val Arg Thr Tyr Tyr Ala Thr Trp Ala 
1               5                   10                  15      


Lys Gly 
        


<210>  199
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  199

Arg Asp Met Gly Phe Ala Asp Tyr Ala Leu Asn Leu 
1               5                   10          


<210>  200
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  200

Gln Ala Ser Glu Ser Ile Tyr Ser Ser Leu Ala 
1               5                   10      


<210>  201
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  201

Leu Ala Ser Thr Leu Ala Ser 
1               5           


<210>  202
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  202

Gln Ser Thr Asp Tyr Thr Thr Ser Thr His Arg Asn Ser 
1               5                   10              


<210>  203
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  203

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Thr Thr 
            20                  25                  30          


Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Thr Asn Thr Ala Ser Ser Val Arg Thr Tyr Tyr Ala Thr 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Met Gly Phe Ala Asp Tyr Ala Leu Asn Leu Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  204
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  204

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Arg Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Thr Thr 
            20                  25                  30          


Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Thr Asn Thr Ala Ser Ser Val Arg Thr Tyr Tyr Ala Thr 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Met Gly Phe Ala Asp Tyr Ala Leu Asn Leu Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  205
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  205

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Tyr Ser Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Thr Asp Tyr Thr Thr Ser 
                85                  90                  95      


Thr His Arg Asn Ser Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


<210>  206
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  206

Gly Phe Asp Leu Ser Ser Tyr Ala Val Ser 
1               5                   10  


<210>  207
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  207

Ile Tyr Pro Arg Ala Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15  


<210>  208
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  208

Arg Asp Arg Tyr Asp Ser Gly Ala Tyr Leu Tyr Thr Thr Tyr Phe Asn 
1               5                   10                  15      


Leu 
    


<210>  209
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  209

Arg Ala Ser Glu Asn Ile Tyr Ser Gly Leu Ala 
1               5                   10      


<210>  210
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  210

Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210>  211
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  211

Gln Gly Gly Tyr Tyr Ser Ser Ser Ser Thr Tyr Ile Ala 
1               5                   10              


<210>  212
<211>  124
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  212

Gln Ser Gln Val Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Asp Leu Ser Ser Tyr 
            20                  25                  30          


Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Tyr Pro Arg Ala Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Asp Arg Tyr Asp Ser Gly Ala Tyr Leu Tyr Thr Thr Tyr Phe Asn 
            100                 105                 110         


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  213
<211>  124
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  213

Gln Ser Gln Val Val Glu Ser Gly Gly Gly Arg Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Asp Leu Ser Ser Tyr 
            20                  25                  30          


Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Tyr Pro Arg Ala Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Asp Arg Tyr Asp Ser Gly Ala Tyr Leu Tyr Thr Thr Tyr Phe Asn 
            100                 105                 110         


Leu Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  214
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  214

Asp Val Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Gly Tyr Tyr Ser Ser Ser 
                85                  90                  95      


Ser Thr Tyr Ile Ala Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


<210>  215
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  215

Gly Leu Ser Leu Ser Arg Asn Ala Met Ser 
1               5                   10  


<210>  216
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  216

Ile Ile Leu Thr Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  217
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  217

Arg Gly Ile Ala Ser Ser Ser Leu Lys Ser Phe 
1               5                   10      


<210>  218
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  218

Gln Ala Ser Gln Asn Val Trp Asn Asn Asn Tyr Leu Ser 
1               5                   10              


<210>  219
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  219

Thr Ala Ser Thr Leu Ala Ser 
1               5           


<210>  220
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  220

Ala Gly Gly Phe Ser Gly Glu Ile Arg Ala 
1               5                   10  


<210>  221
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  221

Gln Ser Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Leu Ser Leu Ser Arg Asn 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Leu Thr Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Val 
                85                  90                  95      


Arg Gly Ile Ala Ser Ser Ser Leu Lys Ser Phe Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  222
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  222

Gln Ser Gln Leu Val Glu Ser Gly Gly Gly Arg Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Leu Ser Leu Ser Arg Asn 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Leu Thr Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Val 
                85                  90                  95      


Arg Gly Ile Ala Ser Ser Ser Leu Lys Ser Phe Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  223
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  223

Ala Gln Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Val Trp Asn Asn 
            20                  25                  30          


Asn Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Val Thr Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Gly 
                85                  90                  95      


Glu Ile Arg Ala Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110     


<210>  224
<211>  516
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  224

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Tyr Ser Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Thr Asp Tyr Thr Thr Ser 
                85                  90                  95      


Thr His Arg Asn Ser Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Arg Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser 
145                 150                 155                 160 


Phe Ser Thr Thr Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys 
                165                 170                 175     


Gly Leu Glu Trp Ile Gly Cys Thr Asn Thr Ala Ser Ser Val Arg Thr 
            180                 185                 190         


Tyr Tyr Ala Thr Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    210                 215                 220                 


Thr Ala Thr Tyr Tyr Cys Ala Arg Asp Met Gly Phe Ala Asp Tyr Ala 
225                 230                 235                 240 


Leu Asn Leu Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
            260                 265                 270         


Gly Gly Arg Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        275                 280                 285             


Ser Gly Phe Ser Leu Ser Ser Tyr Asp Met Ser Trp Val Arg Gln Ala 
    290                 295                 300                 


Pro Gly Lys Gly Leu Ala Trp Ile Gly Ala Ser Tyr Ala Ser Gly Pro 
305                 310                 315                 320 


Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                325                 330                 335     


Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            340                 345                 350         


Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Gly Trp Thr Gly Thr Ser 
        355                 360                 365             


His Ser Asn Ile Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Glu Val Gln Leu 
385                 390                 395                 400 


Val Glu Ser Gly Gly Gly Arg Val Gln Pro Gly Gly Ser Leu Arg Leu 
                405                 410                 415     


Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr Ala Met Asn Trp 
            420                 425                 430         


Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile Gly His Ile Asn 
        435                 440                 445             


Ala Gly Asp Ile Ala Tyr Tyr Ala Thr Trp Ala Lys Gly Arg Phe Thr 
    450                 455                 460                 


Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser 
465                 470                 475                 480 


Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Ala Gly 
                485                 490                 495     


Gly Phe Ser Thr Gly Pro Phe Lys Leu Trp Gly Gln Gly Thr Gln Val 
            500                 505                 510         


Thr Val Ser Ser 
        515     


<210>  225
<211>  493
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  225

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Tyr Ser Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Thr Asp Tyr Thr Thr Ser 
                85                  90                  95      


Thr His Arg Asn Ser Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Arg Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser 
145                 150                 155                 160 


Phe Ser Thr Thr Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys 
                165                 170                 175     


Gly Leu Glu Trp Ile Gly Cys Thr Asn Thr Ala Ser Ser Val Arg Thr 
            180                 185                 190         


Tyr Tyr Ala Thr Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    210                 215                 220                 


Thr Ala Thr Tyr Tyr Cys Ala Arg Asp Met Gly Phe Ala Asp Tyr Ala 
225                 230                 235                 240 


Leu Asn Leu Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Glu Leu Thr Gln Ser Pro 
            260                 265                 270         


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln 
        275                 280                 285             


Ala Ser Glu Ser Ile Asn Ser Arg Leu Ala Trp Tyr Gln Gln Lys Pro 
    290                 295                 300                 


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asp Leu Thr Ser 
305                 310                 315                 320 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                325                 330                 335     


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            340                 345                 350         


Gln Gly Tyr Gly Gly Ser Ser Thr Thr Thr Phe Gly Cys Gly Thr Lys 
        355                 360                 365             


Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Ser Asp Ile Gln Met Thr 
    370                 375                 380                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
385                 390                 395                 400 


Thr Cys Gln Ser Ser Gln Ser Val Phe Ser Asn Asn Tyr Leu Ala Trp 
                405                 410                 415     


Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr Ser Ala 
            420                 425                 430         


Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        435                 440                 445             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    450                 455                 460                 


Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Ala Cys Ser Ser Ala Asp Cys 
465                 470                 475                 480 


Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
                485                 490             


<210>  226
<211>  513
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  226

Ala Phe Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Asn Ser Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Thr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Gly Gly Ser Ser Thr 
                85                  90                  95      


Thr Thr Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Arg Val Gln Pro Gly 
    130                 135                 140                 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser 
145                 150                 155                 160 


Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                165                 170                 175     


Ile Gly His Ile Asn Ala Gly Asp Ile Ala Tyr Tyr Ala Thr Trp Ala 
            180                 185                 190         


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
        195                 200                 205             


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys 
    210                 215                 220                 


Ala Arg Gly Ala Gly Gly Phe Ser Thr Gly Pro Phe Lys Leu Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Arg Val Gln 
            260                 265                 270         


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu 
        275                 280                 285             


Ser Ser Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    290                 295                 300                 


Ala Trp Ile Gly Ala Ser Tyr Ala Ser Gly Pro Thr Tyr Tyr Ala Ser 
305                 310                 315                 320 


Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
                325                 330                 335     


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr 
            340                 345                 350         


Phe Cys Ala Arg Gly Gly Trp Thr Gly Thr Ser His Ser Asn Ile Trp 
        355                 360                 365             


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Ser Gly Gln Ser Gln Leu Val Glu Ser Gly Gly 
385                 390                 395                 400 


Gly Arg Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser 
                405                 410                 415     


Gly Phe Ser Leu Ser Ser Tyr Ala Met Gly Trp Val Arg Gln Ala Pro 
            420                 425                 430         


Gly Lys Cys Leu Glu Tyr Ile Gly Tyr Ile Ser Lys Ile Gly Thr Thr 
        435                 440                 445             


Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn 
    450                 455                 460                 


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
465                 470                 475                 480 


Thr Ala Thr Tyr Phe Cys Ala Arg Gly Ser Ser Ser Gly Gly Tyr Leu 
                485                 490                 495     


Asp Asp Gly Phe Asp Pro Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            500                 505                 510         


Ser 
    


<210>  227
<211>  494
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  227

Ala Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Arg Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Phe Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Tyr Asp Ser Asn Asn 
                85                  90                  95      


Val Glu Asn Val Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Ser Gln Leu Val Glu Ser Gly Gly Gly Arg Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu 
145                 150                 155                 160 


Ser Ser Tyr Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Cys Leu 
                165                 170                 175     


Glu Tyr Ile Gly Tyr Ile Ser Lys Ile Gly Thr Thr Tyr Tyr Ala Ser 
            180                 185                 190         


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr 
        195                 200                 205             


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr 
    210                 215                 220                 


Phe Cys Ala Arg Gly Ser Ser Ser Gly Gly Tyr Leu Asp Asp Gly Phe 
225                 230                 235                 240 


Asp Pro Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Ala Leu Gln Met Thr Gln Ser Pro Ser 
            260                 265                 270         


Ser Leu Ser Ala Arg Val Gly Asp Arg Val Thr Ile Lys Cys Gln Ala 
        275                 280                 285             


Ser Gln Ser Ile Ser Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
    290                 295                 300                 


Lys Pro Pro Lys Phe Leu Ile Tyr Asp Ala Ser Asp Leu Ala Ser Gly 
305                 310                 315                 320 


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr Leu 
                325                 330                 335     


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            340                 345                 350         


Gln Val Tyr Asp Ser Asn Asn Val Glu Asn Val Phe Gly Cys Gly Thr 
        355                 360                 365             


Lys Val Thr Val Leu Gly Gly Gly Ser Gly Gly Ser Asp Ile Gln Met 
    370                 375                 380                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
385                 390                 395                 400 


Ile Thr Cys Gln Ser Ser Gln Ser Val Phe Ser Asn Asn Tyr Leu Ala 
                405                 410                 415     


Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr Ser 
            420                 425                 430         


Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
        435                 440                 445             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
    450                 455                 460                 


Phe Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Ala Cys Ser Ser Ala Asp 
465                 470                 475                 480 


Cys Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
                485                 490                 


<210>  228
<211>  515
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  228

Ala Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Arg Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Phe Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Tyr Asp Ser Asn Asn 
                85                  90                  95      


Val Glu Asn Val Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Ser Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu 
145                 150                 155                 160 


Ser Ser Tyr Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Cys Leu 
                165                 170                 175     


Glu Tyr Ile Gly Tyr Ile Ser Lys Ile Gly Thr Thr Tyr Tyr Ala Ser 
            180                 185                 190         


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr 
        195                 200                 205             


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
    210                 215                 220                 


Phe Cys Ala Arg Gly Ser Ser Ser Gly Gly Tyr Leu Asp Asp Gly Phe 
225                 230                 235                 240 


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        275                 280                 285             


Gly Phe Ser Leu Ser Ser Tyr Asp Met Ser Trp Val Arg Gln Ala Pro 
    290                 295                 300                 


Gly Lys Gly Leu Ala Trp Ile Gly Ala Ser Tyr Ala Ser Gly Pro Thr 
305                 310                 315                 320 


Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                325                 330                 335     


Ser Lys Asn Thr Val Tyr Leu Gln Met Cys Ser Leu Arg Ala Glu Asp 
            340                 345                 350         


Thr Ala Thr Tyr Phe Cys Ala Arg Gly Gly Trp Thr Gly Thr Ser His 
        355                 360                 365             


Ser Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Glu Val Gln Leu Val 
385                 390                 395                 400 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                405                 410                 415     


Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr Ala Met Asn Trp Val 
            420                 425                 430         


Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile Gly His Ile Asn Ala 
        435                 440                 445             


Gly Asp Ile Ala Tyr Tyr Ala Thr Trp Ala Lys Gly Arg Phe Thr Ile 
    450                 455                 460                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
465                 470                 475                 480 


Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg Gly Ala Gly Gly 
                485                 490                 495     


Phe Ser Thr Gly Pro Phe Lys Leu Trp Gly Gln Gly Thr Leu Val Thr 
            500                 505                 510         


Val Ser Ser 
        515 


<210>  229
<211>  499
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  229

Ala Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Arg Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Phe Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Tyr Asp Ser Asn Asn 
                85                  90                  95      


Val Glu Asn Val Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Ser Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu 
145                 150                 155                 160 


Ser Ser Tyr Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Cys Leu 
                165                 170                 175     


Glu Tyr Ile Gly Tyr Ile Ser Lys Ile Gly Thr Thr Tyr Tyr Ala Ser 
            180                 185                 190         


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr 
        195                 200                 205             


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
    210                 215                 220                 


Phe Cys Ala Arg Gly Ser Ser Ser Gly Gly Tyr Leu Asp Asp Gly Phe 
225                 230                 235                 240 


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Ala Phe Glu Leu Thr Gln Ser Pro Ser 
            260                 265                 270         


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala 
        275                 280                 285             


Ser Glu Ser Ile Asn Ser Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
    290                 295                 300                 


Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asp Leu Thr Ser Gly 
305                 310                 315                 320 


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                325                 330                 335     


Thr Ile Ser Cys Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            340                 345                 350         


Gly Tyr Gly Gly Ser Ser Thr Thr Thr Phe Gly Cys Gly Thr Lys Leu 
        355                 360                 365             


Thr Val Leu Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
    370                 375                 380                 


Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
385                 390                 395                 400 


Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Phe Ser 
                405                 410                 415     


Asn Asn Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys 
            420                 425                 430         


Arg Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg 
        435                 440                 445             


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
    450                 455                 460                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Ala 
465                 470                 475                 480 


Cys Ser Ser Ala Asp Cys Tyr Val Phe Gly Thr Gly Thr Lys Val Thr 
                485                 490                 495     


Val Leu Gly 
            


<210>  230
<211>  513
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  230

Ala Phe Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Asn Ser Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Thr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Gly Gly Ser Ser Thr 
                85                  90                  95      


Thr Thr Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    130                 135                 140                 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser 
145                 150                 155                 160 


Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                165                 170                 175     


Ile Gly His Ile Asn Ala Gly Asp Ile Ala Tyr Tyr Ala Thr Trp Ala 
            180                 185                 190         


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
        195                 200                 205             


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
    210                 215                 220                 


Ala Arg Gly Ala Gly Gly Phe Ser Thr Gly Pro Phe Lys Leu Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            260                 265                 270         


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu 
        275                 280                 285             


Ser Ser Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    290                 295                 300                 


Ala Trp Ile Gly Ala Ser Tyr Ala Ser Gly Pro Thr Tyr Tyr Ala Ser 
305                 310                 315                 320 


Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
                325                 330                 335     


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr 
            340                 345                 350         


Phe Cys Ala Arg Gly Gly Trp Thr Gly Thr Ser His Ser Asn Ile Trp 
        355                 360                 365             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Ser Gly Gln Ser Gln Leu Val Glu Ser Gly Gly 
385                 390                 395                 400 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser 
                405                 410                 415     


Gly Phe Ser Leu Ser Ser Tyr Ala Met Gly Trp Val Arg Gln Ala Pro 
            420                 425                 430         


Gly Lys Cys Leu Glu Tyr Ile Gly Tyr Ile Ser Lys Ile Gly Thr Thr 
        435                 440                 445             


Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn 
    450                 455                 460                 


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
465                 470                 475                 480 


Thr Ala Val Tyr Phe Cys Ala Arg Gly Ser Ser Ser Gly Gly Tyr Leu 
                485                 490                 495     


Asp Asp Gly Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            500                 505                 510         


Ser 
    


<210>  231
<211>  501
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  231

Ala Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Arg Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Phe Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Tyr Asp Ser Asn Asn 
                85                  90                  95      


Val Glu Asn Val Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Ser Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu 
145                 150                 155                 160 


Ser Ser Tyr Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Cys Leu 
                165                 170                 175     


Glu Tyr Ile Gly Tyr Ile Ser Lys Ile Gly Thr Thr Tyr Tyr Ala Ser 
            180                 185                 190         


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr 
        195                 200                 205             


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
    210                 215                 220                 


Phe Cys Ala Arg Gly Ser Ser Ser Gly Gly Tyr Leu Asp Asp Gly Phe 
225                 230                 235                 240 


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Ala Leu Gln Met Thr Gln Ser Pro Ser 
            260                 265                 270         


Ser Leu Ser Ala Arg Val Gly Asp Arg Val Thr Ile Lys Cys Gln Ala 
        275                 280                 285             


Ser Gln Ser Ile Ser Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
    290                 295                 300                 


Lys Pro Pro Lys Phe Leu Ile Tyr Asp Ala Ser Asp Leu Ala Ser Gly 
305                 310                 315                 320 


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr Leu 
                325                 330                 335     


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            340                 345                 350         


Gln Val Tyr Asp Ser Asn Asn Val Glu Asn Val Phe Gly Cys Gly Thr 
        355                 360                 365             


Lys Val Thr Val Leu Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    370                 375                 380                 


Gly Ser Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
385                 390                 395                 400 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Ser Val 
                405                 410                 415     


Phe Ser Asn Asn Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser 
            420                 425                 430         


Pro Lys Arg Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro 
        435                 440                 445             


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
    450                 455                 460                 


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ser 
465                 470                 475                 480 


Tyr Ala Cys Ser Ser Ala Asp Cys Tyr Val Phe Gly Thr Gly Thr Lys 
                485                 490                 495     


Val Thr Val Leu Gly 
            500     


<210>  232
<211>  513
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  232

Ala Phe Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Asn Ser Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Thr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Gly Gly Ser Ser Thr 
                85                  90                  95      


Thr Thr Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    130                 135                 140                 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser 
145                 150                 155                 160 


Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                165                 170                 175     


Ile Gly His Ile Asn Ala Gly Asp Ile Ala Tyr Tyr Ala Thr Trp Ala 
            180                 185                 190         


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
        195                 200                 205             


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
    210                 215                 220                 


Ala Arg Gly Ala Gly Gly Phe Ser Thr Gly Pro Phe Lys Leu Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            260                 265                 270         


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu 
        275                 280                 285             


Ser Ser Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    290                 295                 300                 


Ala Trp Ile Gly Ala Ser Tyr Ala Ser Gly Pro Thr Tyr Tyr Ala Ser 
305                 310                 315                 320 


Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
                325                 330                 335     


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr 
            340                 345                 350         


Phe Cys Ala Arg Gly Gly Trp Thr Gly Thr Ser His Ser Asn Ile Trp 
        355                 360                 365             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Ser Gly Gln Ser Gln Leu Val Glu Ser Gly Gly 
385                 390                 395                 400 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser 
                405                 410                 415     


Gly Phe Ser Leu Ser Ser Tyr Ala Met Gly Trp Val Arg Gln Ala Pro 
            420                 425                 430         


Gly Lys Cys Leu Glu Tyr Ile Gly Tyr Ile Ser Lys Ile Gly Thr Thr 
        435                 440                 445             


Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn 
    450                 455                 460                 


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
465                 470                 475                 480 


Thr Ala Val Tyr Phe Cys Ala Arg Gly Ser Ser Ser Gly Gly Tyr Leu 
                485                 490                 495     


Asp Asp Gly Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            500                 505                 510         


Ser 
    


<210>  233
<211>  494
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  233

Ala Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Arg Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Phe Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Tyr Asp Ser Asn Asn 
                85                  90                  95      


Val Glu Asn Val Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Ser Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu 
145                 150                 155                 160 


Ser Ser Tyr Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Cys Leu 
                165                 170                 175     


Glu Tyr Ile Gly Tyr Ile Ser Lys Ile Gly Thr Thr Tyr Tyr Ala Ser 
            180                 185                 190         


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr 
        195                 200                 205             


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
    210                 215                 220                 


Phe Cys Ala Arg Gly Ser Ser Ser Gly Gly Tyr Leu Asp Asp Gly Phe 
225                 230                 235                 240 


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Ala Leu Gln Met Thr Gln Ser Pro Ser 
            260                 265                 270         


Ser Leu Ser Ala Arg Val Gly Asp Arg Val Thr Ile Lys Cys Gln Ala 
        275                 280                 285             


Ser Gln Ser Ile Ser Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
    290                 295                 300                 


Lys Pro Pro Lys Phe Leu Ile Tyr Asp Ala Ser Asp Leu Ala Ser Gly 
305                 310                 315                 320 


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Thr Leu 
                325                 330                 335     


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            340                 345                 350         


Gln Val Tyr Asp Ser Asn Asn Val Glu Asn Val Phe Gly Cys Gly Thr 
        355                 360                 365             


Lys Val Thr Val Leu Gly Gly Gly Ser Gly Gly Ser Asp Ile Gln Met 
    370                 375                 380                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
385                 390                 395                 400 


Ile Thr Cys Gln Ser Ser Gln Ser Val Phe Ser Asn Asn Tyr Leu Ala 
                405                 410                 415     


Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr Ser 
            420                 425                 430         


Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
        435                 440                 445             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
    450                 455                 460                 


Phe Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Ala Cys Ser Ser Ala Asp 
465                 470                 475                 480 


Cys Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
                485                 490                 


<210>  234
<211>  516
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  234

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Tyr Ser Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Thr Asp Tyr Thr Thr Ser 
                85                  90                  95      


Thr His Arg Asn Ser Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser 
145                 150                 155                 160 


Phe Ser Thr Thr Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys 
                165                 170                 175     


Gly Leu Glu Trp Ile Gly Cys Thr Asn Thr Ala Ser Ser Val Arg Thr 
            180                 185                 190         


Tyr Tyr Ala Thr Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Met Gly Phe Ala Asp Tyr Ala 
225                 230                 235                 240 


Leu Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
            260                 265                 270         


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        275                 280                 285             


Ser Gly Phe Ser Leu Ser Ser Tyr Asp Met Ser Trp Val Arg Gln Ala 
    290                 295                 300                 


Pro Gly Lys Gly Leu Ala Trp Ile Gly Ala Ser Tyr Ala Ser Gly Pro 
305                 310                 315                 320 


Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                325                 330                 335     


Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            340                 345                 350         


Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Gly Trp Thr Gly Thr Ser 
        355                 360                 365             


His Ser Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Glu Val Gln Leu 
385                 390                 395                 400 


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
                405                 410                 415     


Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr Ala Met Asn Trp 
            420                 425                 430         


Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile Gly His Ile Asn 
        435                 440                 445             


Ala Gly Asp Ile Ala Tyr Tyr Ala Thr Trp Ala Lys Gly Arg Phe Thr 
    450                 455                 460                 


Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser 
465                 470                 475                 480 


Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg Gly Ala Gly 
                485                 490                 495     


Gly Phe Ser Thr Gly Pro Phe Lys Leu Trp Gly Gln Gly Thr Leu Val 
            500                 505                 510         


Thr Val Ser Ser 
        515     


<210>  235
<211>  493
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  235

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Tyr Ser Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Thr Asp Tyr Thr Thr Ser 
                85                  90                  95      


Thr His Arg Asn Ser Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser 
145                 150                 155                 160 


Phe Ser Thr Thr Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys 
                165                 170                 175     


Gly Leu Glu Trp Ile Gly Cys Thr Asn Thr Ala Ser Ser Val Arg Thr 
            180                 185                 190         


Tyr Tyr Ala Thr Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Met Gly Phe Ala Asp Tyr Ala 
225                 230                 235                 240 


Leu Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Glu Leu Thr Gln Ser Pro 
            260                 265                 270         


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln 
        275                 280                 285             


Ala Ser Glu Ser Ile Asn Ser Arg Leu Ala Trp Tyr Gln Gln Lys Pro 
    290                 295                 300                 


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asp Leu Thr Ser 
305                 310                 315                 320 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                325                 330                 335     


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            340                 345                 350         


Gln Gly Tyr Gly Gly Ser Ser Thr Thr Thr Phe Gly Cys Gly Thr Lys 
        355                 360                 365             


Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Ser Asp Ile Gln Met Thr 
    370                 375                 380                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
385                 390                 395                 400 


Thr Cys Gln Ser Ser Gln Ser Val Phe Ser Asn Asn Tyr Leu Ala Trp 
                405                 410                 415     


Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr Ser Ala 
            420                 425                 430         


Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        435                 440                 445             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    450                 455                 460                 


Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Ala Cys Ser Ser Ala Asp Cys 
465                 470                 475                 480 


Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
                485                 490             


<210>  236
<211>  751
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  236

Ala Phe Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Asn Ser Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Thr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Gly Gly Ser Ser Thr 
                85                  90                  95      


Thr Thr Phe Gly Cys Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly 
            100                 105                 110         


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
        115                 120                 125             


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser 
    130                 135                 140                 


Ser Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Ala 
145                 150                 155                 160 


Trp Ile Gly Ala Ser Tyr Ala Ser Gly Pro Thr Tyr Tyr Ala Ser Trp 
                165                 170                 175     


Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
            180                 185                 190         


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe 
        195                 200                 205             


Cys Ala Arg Gly Gly Trp Thr Gly Thr Ser His Ser Asn Ile Trp Gly 
    210                 215                 220                 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
                245                 250                 255     


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
            260                 265                 270         


Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Phe Ser Asn Asn Tyr Leu 
        275                 280                 285             


Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr 
    290                 295                 300                 


Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
305                 310                 315                 320 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
                325                 330                 335     


Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Ala Cys Ser Ser Ala 
            340                 345                 350         


Asp Cys Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
        355                 360                 365             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    370                 375                 380                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser 
385                 390                 395                 400 


Leu Ser Ser Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys 
                405                 410                 415     


Leu Glu Trp Ile Gly His Ile Asn Ala Gly Asp Ile Ala Tyr Tyr Ala 
            420                 425                 430         


Thr Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
        435                 440                 445             


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
    450                 455                 460                 


Tyr Phe Cys Ala Arg Gly Ala Gly Gly Phe Ser Thr Gly Pro Phe Lys 
465                 470                 475                 480 


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Gly Gly Gly Gly Ser Ala Gln Gln Leu Thr Gln Ser Pro Ser Ser 
            500                 505                 510         


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
        515                 520                 525             


Gln Asn Val Trp Asn Asn Asn Tyr Leu Ser Trp Phe Gln Gln Lys Pro 
    530                 535                 540                 


Gly Lys Pro Pro Lys Leu Leu Ile Val Thr Ala Ser Thr Leu Ala Ser 
545                 550                 555                 560 


Gly Val Ser Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                565                 570                 575     


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            580                 585                 590         


Ala Gly Gly Phe Ser Gly Glu Ile Arg Ala Phe Gly Cys Gly Thr Lys 
        595                 600                 605             


Val Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    610                 615                 620                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Gln Leu Val Glu Ser 
625                 630                 635                 640 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
                645                 650                 655     


Val Ser Gly Leu Ser Leu Ser Arg Asn Ala Met Ser Trp Val Arg Gln 
            660                 665                 670         


Ala Pro Gly Lys Cys Leu Glu Trp Ile Gly Ile Ile Leu Thr Ser Gly 
        675                 680                 685             


Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys 
    690                 695                 700                 


Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala 
705                 710                 715                 720 


Glu Asp Thr Ala Val Tyr Phe Cys Val Arg Gly Ile Ala Ser Ser Ser 
                725                 730                 735     


Leu Lys Ser Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            740                 745                 750     


<210>  237
<211>  751
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  237

Ala Phe Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Asn Ser Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Thr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Gly Gly Ser Ser Thr 
                85                  90                  95      


Thr Thr Phe Gly Cys Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly 
            100                 105                 110         


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Arg Val Gln Pro 
        115                 120                 125             


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser 
    130                 135                 140                 


Ser Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Ala 
145                 150                 155                 160 


Trp Ile Gly Ala Ser Tyr Ala Ser Gly Pro Thr Tyr Tyr Ala Ser Trp 
                165                 170                 175     


Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
            180                 185                 190         


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe 
        195                 200                 205             


Cys Ala Arg Gly Gly Trp Thr Gly Thr Ser His Ser Asn Ile Trp Gly 
    210                 215                 220                 


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
                245                 250                 255     


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
            260                 265                 270         


Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Phe Ser Asn Asn Tyr Leu 
        275                 280                 285             


Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr 
    290                 295                 300                 


Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
305                 310                 315                 320 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
                325                 330                 335     


Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Ala Cys Ser Ser Ala 
            340                 345                 350         


Asp Cys Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
        355                 360                 365             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Arg Val 
    370                 375                 380                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser 
385                 390                 395                 400 


Leu Ser Ser Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys 
                405                 410                 415     


Leu Glu Trp Ile Gly His Ile Asn Ala Gly Asp Ile Ala Tyr Tyr Ala 
            420                 425                 430         


Thr Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
        435                 440                 445             


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr 
    450                 455                 460                 


Tyr Phe Cys Ala Arg Gly Ala Gly Gly Phe Ser Thr Gly Pro Phe Lys 
465                 470                 475                 480 


Leu Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Gly Gly Gly Gly Ser Ala Gln Gln Leu Thr Gln Ser Pro Ser Ser 
            500                 505                 510         


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
        515                 520                 525             


Gln Asn Val Trp Asn Asn Asn Tyr Leu Ser Trp Phe Gln Gln Lys Pro 
    530                 535                 540                 


Gly Lys Pro Pro Lys Leu Leu Ile Val Thr Ala Ser Thr Leu Ala Ser 
545                 550                 555                 560 


Gly Val Ser Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                565                 570                 575     


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            580                 585                 590         


Ala Gly Gly Phe Ser Gly Glu Ile Arg Ala Phe Gly Cys Gly Thr Lys 
        595                 600                 605             


Val Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    610                 615                 620                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Gln Leu Val Glu Ser 
625                 630                 635                 640 


Gly Gly Gly Arg Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
                645                 650                 655     


Val Ser Gly Leu Ser Leu Ser Arg Asn Ala Met Ser Trp Val Arg Gln 
            660                 665                 670         


Ala Pro Gly Lys Cys Leu Glu Trp Ile Gly Ile Ile Leu Thr Ser Gly 
        675                 680                 685             


Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys 
    690                 695                 700                 


Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala 
705                 710                 715                 720 


Glu Asp Thr Ala Thr Tyr Phe Cys Val Arg Gly Ile Ala Ser Ser Ser 
                725                 730                 735     


Leu Lys Ser Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            740                 745                 750     


<210>  238
<211>  495
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  238

Asp Val Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Gly Tyr Tyr Ser Ser Ser 
                85                  90                  95      


Ser Thr Tyr Ile Ala Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Ser Gln Val Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Asp 
145                 150                 155                 160 


Leu Ser Ser Tyr Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Cys 
                165                 170                 175     


Leu Glu Trp Ile Gly Ile Ile Tyr Pro Arg Ala Asn Thr Tyr Tyr Ala 
            180                 185                 190         


Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn 
        195                 200                 205             


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Phe Cys Ala Arg Asp Arg Tyr Asp Ser Gly Ala Tyr Leu Tyr Thr 
225                 230                 235                 240 


Thr Tyr Phe Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Glu Leu Thr Gln 
            260                 265                 270         


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
        275                 280                 285             


Cys Gln Ala Ser Glu Ser Ile Asn Ser Arg Leu Ala Trp Tyr Gln Gln 
    290                 295                 300                 


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asp Leu 
305                 310                 315                 320 


Thr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                325                 330                 335     


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
            340                 345                 350         


Tyr Cys Gln Gly Tyr Gly Gly Ser Ser Thr Thr Thr Phe Gly Cys Gly 
        355                 360                 365             


Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Ser Asp Ile Gln 
    370                 375                 380                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
385                 390                 395                 400 


Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Phe Ser Asn Asn Tyr Leu 
                405                 410                 415     


Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr 
            420                 425                 430         


Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
        435                 440                 445             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
    450                 455                 460                 


Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Ala Cys Ser Ser Ala 
465                 470                 475                 480 


Asp Cys Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
                485                 490                 495 


<210>  239
<211>  518
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  239

Asp Val Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Gly Tyr Tyr Ser Ser Ser 
                85                  90                  95      


Ser Thr Tyr Ile Ala Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Ser Gln Val Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Asp 
145                 150                 155                 160 


Leu Ser Ser Tyr Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Cys 
                165                 170                 175     


Leu Glu Trp Ile Gly Ile Ile Tyr Pro Arg Ala Asn Thr Tyr Tyr Ala 
            180                 185                 190         


Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn 
        195                 200                 205             


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Phe Cys Ala Arg Asp Arg Tyr Asp Ser Gly Ala Tyr Leu Tyr Thr 
225                 230                 235                 240 


Thr Tyr Phe Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
            260                 265                 270         


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        275                 280                 285             


Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr Asp Met Ser Trp Val Arg 
    290                 295                 300                 


Gln Ala Pro Gly Lys Gly Leu Ala Trp Ile Gly Ala Ser Tyr Ala Ser 
305                 310                 315                 320 


Gly Pro Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
            340                 345                 350         


Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Gly Trp Thr Gly 
        355                 360                 365             


Thr Ser His Ser Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    370                 375                 380                 


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Glu Val 
385                 390                 395                 400 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                405                 410                 415     


Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr Ala Met 
            420                 425                 430         


Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile Gly His 
        435                 440                 445             


Ile Asn Ala Gly Asp Ile Ala Tyr Tyr Ala Thr Trp Ala Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met 
465                 470                 475                 480 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg Gly 
                485                 490                 495     


Ala Gly Gly Phe Ser Thr Gly Pro Phe Lys Leu Trp Gly Gln Gly Thr 
            500                 505                 510         


Leu Val Thr Val Ser Ser 
        515             


<210>  240
<211>  495
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  240

Asp Val Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Gly Tyr Tyr Ser Ser Ser 
                85                  90                  95      


Ser Thr Tyr Ile Ala Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Ser Gln Val Val Glu Ser Gly Gly Gly Arg Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Asp 
145                 150                 155                 160 


Leu Ser Ser Tyr Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Cys 
                165                 170                 175     


Leu Glu Trp Ile Gly Ile Ile Tyr Pro Arg Ala Asn Thr Tyr Tyr Ala 
            180                 185                 190         


Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn 
        195                 200                 205             


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr 
    210                 215                 220                 


Tyr Phe Cys Ala Arg Asp Arg Tyr Asp Ser Gly Ala Tyr Leu Tyr Thr 
225                 230                 235                 240 


Thr Tyr Phe Asn Leu Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Glu Leu Thr Gln 
            260                 265                 270         


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
        275                 280                 285             


Cys Gln Ala Ser Glu Ser Ile Asn Ser Arg Leu Ala Trp Tyr Gln Gln 
    290                 295                 300                 


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asp Leu 
305                 310                 315                 320 


Thr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                325                 330                 335     


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
            340                 345                 350         


Tyr Cys Gln Gly Tyr Gly Gly Ser Ser Thr Thr Thr Phe Gly Cys Gly 
        355                 360                 365             


Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Ser Asp Ile Gln 
    370                 375                 380                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
385                 390                 395                 400 


Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Phe Ser Asn Asn Tyr Leu 
                405                 410                 415     


Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr 
            420                 425                 430         


Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
        435                 440                 445             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
    450                 455                 460                 


Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Ala Cys Ser Ser Ala 
465                 470                 475                 480 


Asp Cys Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
                485                 490                 495 


<210>  241
<211>  518
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  241

Asp Val Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Gly Tyr Tyr Ser Ser Ser 
                85                  90                  95      


Ser Thr Tyr Ile Ala Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Ser Gln Val Val Glu Ser Gly Gly Gly Arg Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Asp 
145                 150                 155                 160 


Leu Ser Ser Tyr Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Cys 
                165                 170                 175     


Leu Glu Trp Ile Gly Ile Ile Tyr Pro Arg Ala Asn Thr Tyr Tyr Ala 
            180                 185                 190         


Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn 
        195                 200                 205             


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr 
    210                 215                 220                 


Tyr Phe Cys Ala Arg Asp Arg Tyr Asp Ser Gly Ala Tyr Leu Tyr Thr 
225                 230                 235                 240 


Thr Tyr Phe Asn Leu Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
            260                 265                 270         


Ser Gly Gly Gly Arg Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        275                 280                 285             


Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr Asp Met Ser Trp Val Arg 
    290                 295                 300                 


Gln Ala Pro Gly Lys Gly Leu Ala Trp Ile Gly Ala Ser Tyr Ala Ser 
305                 310                 315                 320 


Gly Pro Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
            340                 345                 350         


Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Gly Trp Thr Gly 
        355                 360                 365             


Thr Ser His Ser Asn Ile Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
    370                 375                 380                 


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Glu Val 
385                 390                 395                 400 


Gln Leu Val Glu Ser Gly Gly Gly Arg Val Gln Pro Gly Gly Ser Leu 
                405                 410                 415     


Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr Ala Met 
            420                 425                 430         


Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile Gly His 
        435                 440                 445             


Ile Asn Ala Gly Asp Ile Ala Tyr Tyr Ala Thr Trp Ala Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met 
465                 470                 475                 480 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                485                 490                 495     


Ala Gly Gly Phe Ser Thr Gly Pro Phe Lys Leu Trp Gly Gln Gly Thr 
            500                 505                 510         


Gln Val Thr Val Ser Ser 
        515             


