                               SEQUENCE LISTING

<110> SANOFI
 
<120> NOVEL LIGANDS FOR ASIALOGLYCOPROTEIN RECEPTOR

<130> 022548.P1059

<140>
<141>

<160> 10    

<170> PatentIn version 3.5

<210> 1
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> GalNAc-morpholino-thymidine analog 3

<220>
<221> modified_base
<222> (2)..(2)
<223> GalNAc-morpholino-thymidine analog 3

<220>
<221> modified_base
<222> (3)..(3)
<223> GalNAc-morpholino-thymidine analog 3

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> misc_feature
<222> (20)..(21)
<223> /note="phosphorothiate linkage" 

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-OMe-nucleotide 

<220>
<221> misc_feature
<222> (21)..(22)
<223> /note="phosphorothiate linkage" 

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-deoxy-fluoro-nucleotide 

<400> 1
tttaucguac guaccgucgu au                                                22


<210> 2
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> GalNAc-morpholino-thymidine analog 3

<220>
<221> modified_base
<222> (2)..(2)
<223> GalNAc-morpholino-thymidine analog 3

<220>
<221> modified_base
<222> (3)..(3)
<223> GalNAc-morpholino-thymidine analog 3

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (23)..(23)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (24)..(24)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (25)..(25)
<223> Cyclohexane-morpholino-thymidine analog 4

<220>
<221> modified_base
<222> (26)..(26)
<223> Cyclohexane-morpholino-thymidine analog 4

<400> 2
tttaacagug uucuugcucu auaatt                                            26


<210> 3
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> GalNAc-morpholino-thymidine analog 7

<220>
<221> modified_base
<222> (2)..(2)
<223> GalNAc-morpholino-thymidine analog 7

<220>
<221> modified_base
<222> (3)..(3)
<223> GalNAc-morpholino-thymidine analog 7

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (23)..(23)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (24)..(24)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (25)..(25)
<223> Cyclohexane-morpholino-thymidine analog 4

<220>
<221> modified_base
<222> (26)..(26)
<223> Cyclohexane-morpholino-thymidine analog 4

<400> 3
tttaacagug uucuugcucu auaatt                                            26


<210> 4
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Piperidine-morpholino-thymidine analog 1

<220>
<221> modified_base
<222> (2)..(2)
<223> Piperidine-morpholino-thymidine analog 1

<220>
<221> modified_base
<222> (3)..(3)
<223> Piperidine-morpholino-thymidine analog 1

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (23)..(23)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (24)..(24)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (25)..(25)
<223> Cyclohexane-morpholino-thymidine analog 4

<220>
<221> modified_base
<222> (26)..(26)
<223> Cyclohexane-morpholino-thymidine analog 4

<400> 4
tttaacagug uucuugcucu auaatt                                            26


<210> 5
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Guanosine-morpholino-thymidine analog 1

<220>
<221> modified_base
<222> (2)..(2)
<223> Guanosine-morpholino-thymidine analog 1

<220>
<221> modified_base
<222> (3)..(3)
<223> Guanosine-morpholino-thymidine analog 1

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (23)..(23)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (24)..(24)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (25)..(25)
<223> Cyclohexane-morpholino-thymidine analog 4

<220>
<221> modified_base
<222> (26)..(26)
<223> Cyclohexane-morpholino-thymidine analog 4

<400> 5
tttaacagug uucuugcucu auaatt                                            26


<210> 6
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Guanosine-morpholino-thymidine analog 2

<220>
<221> modified_base
<222> (2)..(2)
<223> Guanosine-morpholino-thymidine analog 2

<220>
<221> modified_base
<222> (3)..(3)
<223> Guanosine-morpholino-thymidine analog 2

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (23)..(23)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (24)..(24)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (25)..(25)
<223> Cyclohexane-morpholino-thymidine analog 4

<220>
<221> modified_base
<222> (26)..(26)
<223> Cyclohexane-morpholino-thymidine analog 4

<400> 6
tttaacagug uucuugcucu auaatt                                            26


<210> 7
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Guanosine-morpholino-thymidine analog 3

<220>
<221> modified_base
<222> (2)..(2)
<223> Guanosine-morpholino-thymidine analog 3

<220>
<221> modified_base
<222> (3)..(3)
<223> Guanosine-morpholino-thymidine analog 3

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (23)..(23)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (24)..(24)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (25)..(25)
<223> Cyclohexane-morpholino-thymidine analog 4

<220>
<221> modified_base
<222> (26)..(26)
<223> Cyclohexane-morpholino-thymidine analog 4

<400> 7
tttaacagug uucuugcucu auaatt                                            26


<210> 8
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> misc_feature
<222> (1)..(2)
<223> /note="phosphorothiate linkage" 

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> misc_feature
<222> (2)..(3)
<223> /note="phosphorothiate linkage" 

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-OMe-nucleotide 

<220>
<221> misc_feature
<222> (19)..(20)
<223> /note="phosphorothiate linkage" 

<220>
<221> modified_base
<222> (20)..(20)
<223> dT

<220>
<221> misc_feature
<222> (20)..(21)
<223> /note="phosphorothiate linkage" 

<220>
<221> modified_base
<222> (21)..(21)
<223> dT

<400> 8
auacgacggu acguacgaut t                                                 21


<210> 9
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-OMe-nucleotide 

<220>
<221> misc_feature
<222> (1)..(2)
<223> /note="phosphorothiate linkage" 

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> misc_feature
<222> (2)..(3)
<223> /note="phosphorothiate linkage" 

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-OMe-nucleotide 

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-deoxy-fluoro-nucleotide 

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-OMe-nucleotide 

<220>
<221> misc_feature
<222> (21)..(22)
<223> /note="phosphorothiate linkage" 

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-OMe-nucleotide 

<220>
<221> misc_feature
<222> (22)..(23)
<223> /note="phosphorothiate linkage" 

<220>
<221> modified_base
<222> (23)..(23)
<223> 2'-OMe-nucleotide 

<400> 9
uuauagagca agaacacugu uuu                                               23


<210> 10
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(16)
<223> dT 

<400> 10
tttttttttt tttttt                                                       16


