                             LISTA DE SECUENCIAS                              

<110> CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA

<120> ANTIGENO QUIMERICO QUE COMPRENDE EL DOMINIO
      EXTRACELULAR DE PD-L1

<130> antgeno quimrico PD-L1

<140> CU 2020-0075
<141> 2020-10-22

<160> 24                            

<170> PatentIn Ver. 2.1

<210> 1
<211> 290
<212> PRT
<213> Secuencia Artificial

<220> 
<223> Descripcin de la Secuencia Artificial: Antgeno
      quimrico PKPD-L1

<400> 1
Met Val Asp Lys Arg Met Ala Leu Val Glu Leu Lys Val Pro Asp Ile  
  1               5                  10                  15    

Gly Gly His Glu Asn Val Asp Ile Ile Ala Val Glu Val Asn Val Gly  
             20                  25                  30        

Asp Thr Ile Ala Val Asp Asp Thr Leu Ile Thr Leu Asp Leu Asp His  
         35                  40                  45            

Asp Asp Asp Asp Asp Lys Ala Ser Asp Leu Leu Ala Phe Thr Val Thr  
     50                  55                  60                

Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile  
 65                  70                  75                  80

Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile  
                 85                  90                  95    

Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly  
            100                 105                 110        

Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg  
        115                 120                 125            

Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr  
    130                 135                 140                

Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr  
145                 150                 155                 160

Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val Asn Ala Pro Tyr  
                165                 170                 175    

Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro Val Thr Ser Glu  
            180                 185                 190        

His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys Ala Glu Val Ile  
        195                 200                 205            

Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys Thr Thr Thr Thr  
    210                 215                 220                

Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr Ser Thr Leu Arg  
225                 230                 235                 240

Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr Phe Arg Arg Leu  
                245                 250                 255    

Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile Pro Glu Leu Pro  
            260                 265                 270        

Leu Ala His Pro Pro Asn Glu Arg Gly Ser Arg Ala His His His His  
        275                 280                 285            

His His                                                          
    290


<210> 2
<211> 31
<212> ADN
<213> Homo sapiens

<400> 2
gatctgctag cctttaccgt taccgtcccg a                                31    


<210> 3
<211> 60
<212> ADN
<213> Homo sapiens

<400> 3
aatggtcata ttgctgccat attctaccac atacaaatct ttcgggacgg taacggtaaa 60    


<210> 4
<211> 60
<212> ADN
<213> Homo sapiens

<400> 4
aatatggcag caatatgacc attgaatgca aatttccggt ggaaaaacag ctggatctgg 60    


<210> 5
<211> 60
<212> ADN
<213> Homo sapiens

<400> 5
tattcttatc ttccatttcc caatacacaa ttaacgccgc cagatccagc tgtttttcca 60    


<210> 6
<211> 60
<212> ADN
<213> Homo sapiens

<400> 6
tgtattggga aatggaagat aagaatatca ttcagtttgt gcatggcgaa gaagatctga 60    


<210> 7
<211> 60
<212> ADN
<213> Homo sapiens

<400> 7
agcagacgag cacgctgacg atagctgcta tgctgcactt tcagatcttc ttcgccatgc 60    


<210> 8
<211> 60
<212> ADN
<213> Homo sapiens

<400> 8
agcgtgctcg tctgctgaaa gatcaactga gcctgggcaa tgcggcgctg cagattaccg 60    


<210> 9
<211> 60
<212> ADN
<213> Homo sapiens

<400> 9
ctaatcatgc aacgatacac gcccgcatcc tgcagtttca cgtcggtaat ctgcagcgcc 60    


<210> 10
<211> 60
<212> ADN
<213> Homo sapiens

<400> 10
gcgtgtatcg ttgcatgatt agctatggcg gagcggacta taaacgtatt accgtgaagg 60    


<210> 11
<211> 60
<212> ADN
<213> Homo sapiens

<400> 11
aatccgctgg ttaatcttat tgtacggcgc attcaccttc acggtaatac gtttatagtc 60    


<210> 12
<211> 60
<212> ADN
<213> Homo sapiens

<400> 12
gtacaataag attaaccagc ggattctggt ggtggacccg gtgaccagcg aacatgaact 60    


<210> 13
<211> 60
<212> ADN
<213> Homo sapiens

<400> 13
aatcacttcc gctttcggat agccttccgc ctggcaggtc agttcatgtt cgctggtcac 60    


<210> 14
<211> 60
<212> ADN
<213> Homo sapiens

<400> 14
tatccgaaag cggaagtgat ttggaccagc agcgatcatc aggtgctgtc aggcaagacc 60    


<210> 15
<211> 60
<212> ADN
<213> Homo sapiens

<400> 15
gacgttaaaa agcttctcct cgcgtttgct gttggtggta gtggtcttgc ctgacagcac 60    


<210> 16
<211> 59
<212> ADN
<213> Homo sapiens

<400> 16
cgaggagaag ctttttaacg tcaccagcac cctgcgtatt aacactacta ccaacgaaa  59    


<210> 17
<211> 60
<212> ADN
<213> Homo sapiens

<400> 17
ttccggatct aaacgacgaa aggtgcaata gaaaatttcg ttggtagtag tgttaatacg 60    


<210> 18
<211> 60
<212> ADN
<213> Homo sapiens

<400> 18
tttcgtcgtt tagatccgga agaaaatcat accgccgaac tggtgattcc ggagctgccg 60    


<210> 19
<211> 47
<212> ADN
<213> Homo sapiens

<400> 19
ggatccacgt tcattcggtg gatgcgccag cggcagctcc ggaatca               47    


<210> 20
<211> 31
<212> ADN
<213> Secuencia Artificial

<220> 
<223> Descripcin de la Secuencia
      Artificial: Oligonucletido sinttico para la
      clonacin en pM238

<400> 20
gatctgctag cctttaccgt taccgtcccg a                                31    


<210> 21
<211> 50
<212> ADN
<213> Secuencia Artificial

<220> 
<223> Descripcin de la Secuencia
      Artificial: Oligonucletido sinttico para la
      clonacin en pM238

<400> 21
gggggatcca cgttcattcg gtggatgcgc cagcggcagc tccggaatca            50    


<210> 22
<211> 870
<212> ADN
<213> Secuencia Artificial

<220> 
<223> Descripcin de la Secuencia Artificial: Secuencia
      de nucletidos de la regin codificante para
      PKPD-L1

<400> 22
atggtagata aaagaatggc tttagttgaa ttgaaagtgc ccgacattgg cggacacgaa 60    
aatgtagata ttatcgcggt tgaagtaaac gtgggcgaca ctattgctgt ggacgatacc 120   
ctgattactt tggatctaga tcacgatgac gatgacgata aagcttcaga tctgctagcc 180   
tttaccgtta ccgtcccgaa agatttgtat gtggtagaat atggcagcaa tatgaccatt 240   
gaatgcaaat ttccggtgga aaaacagctg gatctggcgg cgttaattgt gtattgggaa 300   
atggaagata agaatatcat tcagtttgtg catggcgaag aagatctgaa agtgcagcat 360   
agcagctatc gtcagcgtgc tcgtctgctg aaagatcaac tgagcctggg caatgcggcg 420   
ctgcagatta ccgacgtgaa actgcaggat gcgggcgtgt atcgttgcat gattagctat 480   
ggcggagcgg actataaacg tattaccgtg aaggtgaatg cgccgtacaa taagattaac 540   
cagcggattc tggtggtgga cccggtgacc agcgaacatg aactgacctg ccaggcggaa 600   
ggctatccga aagcggaagt gatttggacc agcagcgatc atcaggtgct gtcaggcaag 660   
accactacca ccaacagcaa acgcgaggag aagcttttta acgtcaccag caccctgcgt 720   
attaacacta ctaccaacga aattttctat tgcacctttc gtcgtttaga tccggaagaa 780   
aatcataccg ccgaactggt gattccggag ctgccgctgg cgcatccacc gaatgaacgt 840   
ggatcccggg cacaccatca ccatcaccat                                  870   


<210> 23
<211> 19
<212> PRT
<213> Homo sapiens

<400> 23
Phe Met Thr Tyr Trp His Leu Leu Asn Ala Phe Thr Val Thr Val Pro  
  1               5                  10                  15    

Lys Asp Leu                                                      
           


<210> 24
<211> 23
<212> PRT
<213> Homo sapiens

<400> 24
Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr Phe  
  1               5                  10                  15    

Ile Phe Arg Leu Arg Lys Gly                                      
             20            






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