 б

<110>  ʡԤģʡоԺ＼ɷ޹˾ʤƼ޹˾

<120>  ԭＰӦ

<130>  0107-PA-003

<160>  111

<170>  PatentIn version 3.5

<210>  1
<211>  243
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  RBD-P2


<400>  1

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Gly 
    210                 215                 220                 


Ser Gly Ser Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile 
225                 230                 235                 240 


Thr Glu Leu 
            


<210>  2
<211>  243
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  P2-RBD

<400>  2

Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Gly 
1               5                   10                  15      


Ser Gly Ser Gly Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro 
            20                  25                  30          


Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
        35                  40                  45              


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
    50                  55                  60                  


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
65                  70                  75                  80  


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
                85                  90                  95      


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
            100                 105                 110         


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
        115                 120                 125             


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
    130                 135                 140                 


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
145                 150                 155                 160 


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
                165                 170                 175     


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
            180                 185                 190         


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
        195                 200                 205             


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
    210                 215                 220                 


Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys 
225                 230                 235                 240 


Val Asn Phe 
            


<210>  3
<211>  255
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  RBD-foldon

<400>  3

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Gly 
    210                 215                 220                 


Ser Gly Ser Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr 
225                 230                 235                 240 


Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly 
                245                 250                 255 


<210>  4
<211>  411
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  RBD-ferritin LC

<400>  4

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Gly 
    210                 215                 220                 


Ser Gly Ser Gly Glu Tyr Gly Ser His Gly Asn Val Ala Thr Glu Leu 
225                 230                 235                 240 


Gln Ala Tyr Ala Lys Leu His Leu Glu Arg Ser Tyr Asp Tyr Leu Leu 
                245                 250                 255     


Ser Ala Ala Tyr Phe Asn Asn Tyr Gln Thr Asn Arg Ala Gly Phe Ser 
            260                 265                 270         


Lys Leu Phe Lys Lys Leu Ser Asp Glu Ala Trp Ser Lys Thr Ile Asp 
        275                 280                 285             


Ile Ile Lys His Val Thr Lys Arg Gly Asp Lys Met Asn Phe Asp Gln 
    290                 295                 300                 


His Ser Thr Met Lys Thr Glu Arg Lys Asn Tyr Thr Ala Glu Asn His 
305                 310                 315                 320 


Glu Leu Glu Ala Leu Ala Lys Ala Leu Asp Thr Gln Lys Glu Leu Ala 
                325                 330                 335     


Glu Arg Ala Phe Tyr Ile His Arg Glu Ala Thr Arg Asn Ser Gln His 
            340                 345                 350         


Leu His Asp Pro Glu Ile Ala Gln Tyr Leu Glu Glu Glu Phe Ile Glu 
        355                 360                 365             


Asp His Ala Glu Lys Ile Arg Thr Leu Ala Gly His Thr Ser Asp Leu 
    370                 375                 380                 


Lys Lys Phe Ile Thr Ala Asn Asn Gly His Asp Leu Ser Leu Ala Leu 
385                 390                 395                 400 


Tyr Val Phe Asp Glu Tyr Leu Gln Lys Thr Val 
                405                 410     


<210>  5
<211>  409
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  RBD-ferritin HC

<400>  5

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Gly 
    210                 215                 220                 


Ser Gly Ser Gly Arg Ser Cys Arg Asn Ser Met Arg Gln Gln Ile Gln 
225                 230                 235                 240 


Met Glu Val Gly Ala Ser Leu Gln Tyr Leu Ala Met Gly Ala His Phe 
                245                 250                 255     


Ser Lys Asp Val Val Asn Arg Pro Gly Phe Ala Gln Leu Phe Phe Asp 
            260                 265                 270         


Ala Ala Ser Glu Glu Arg Glu His Ala Met Lys Leu Ile Glu Tyr Leu 
        275                 280                 285             


Leu Met Arg Gly Glu Leu Thr Asn Asp Val Ser Ser Leu Leu Gln Val 
    290                 295                 300                 


Arg Pro Pro Thr Arg Ser Ser Trp Lys Gly Gly Val Glu Ala Leu Glu 
305                 310                 315                 320 


His Ala Leu Ser Met Glu Ser Asp Val Thr Lys Ser Ile Arg Asn Val 
                325                 330                 335     


Ile Lys Ala Cys Glu Asp Asp Ser Glu Phe Asn Asp Tyr His Leu Val 
            340                 345                 350         


Asp Tyr Leu Thr Gly Asp Phe Leu Glu Glu Gln Tyr Lys Gly Gln Arg 
        355                 360                 365             


Asp Leu Ala Gly Lys Ala Ser Thr Leu Lys Lys Leu Met Asp Arg His 
    370                 375                 380                 


Glu Ala Leu Gly Glu Phe Ile Phe Asp Lys Lys Leu Leu Gly Ile Asp 
385                 390                 395                 400 


Val Asp Tyr Lys Asp Asp Asp Asp Lys 
                405                 


<210>  6
<211>  454
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  RBD-HBsAg

<400>  6

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Gly 
    210                 215                 220                 


Ser Gly Ser Gly Met Glu Asn Ile Thr Ser Gly Phe Leu Gly Pro Leu 
225                 230                 235                 240 


Leu Val Leu Gln Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile 
                245                 250                 255     


Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly 
            260                 265                 270         


Ser Pro Val Cys Leu Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn His 
        275                 280                 285             


Ser Pro Thr Ser Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met Cys 
    290                 295                 300                 


Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile 
305                 310                 315                 320 


Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro 
                325                 330                 335     


Leu Ile Pro Gly Ser Thr Thr Thr Ser Thr Gly Pro Cys Lys Thr Cys 
            340                 345                 350         


Thr Thr Pro Ala Gln Gly Asn Ser Met Phe Pro Ser Cys Cys Cys Thr 
        355                 360                 365             


Lys Pro Thr Asp Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp 
    370                 375                 380                 


Ala Phe Ala Lys Tyr Leu Trp Glu Trp Ala Ser Val Arg Phe Ser Trp 
385                 390                 395                 400 


Leu Ser Leu Leu Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro 
                405                 410                 415     


Thr Val Trp Leu Ser Ala Ile Trp Met Met Trp Tyr Trp Gly Pro Ser 
            420                 425                 430         


Leu Tyr Ser Ile Val Ser Pro Phe Ile Pro Leu Leu Pro Ile Phe Phe 
        435                 440                 445             


Cys Leu Trp Val Tyr Ile 
    450                 


<210>  7
<211>  275
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  RBD-P2-foldon

<400>  7

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Gly 
    210                 215                 220                 


Ser Gly Ser Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile 
225                 230                 235                 240 


Thr Glu Leu Gly Ser Gly Ser Gly Tyr Ile Pro Glu Ala Pro Arg Asp 
                245                 250                 255     


Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr 
            260                 265                 270         


Phe Leu Gly 
        275 


<210>  8
<211>  275
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  P2-RBD-foldon

<400>  8

Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Gly 
1               5                   10                  15      


Ser Gly Ser Gly Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro 
            20                  25                  30          


Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
        35                  40                  45              


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
    50                  55                  60                  


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
65                  70                  75                  80  


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
                85                  90                  95      


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
            100                 105                 110         


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
        115                 120                 125             


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
    130                 135                 140                 


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
145                 150                 155                 160 


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
                165                 170                 175     


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
            180                 185                 190         


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
        195                 200                 205             


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
    210                 215                 220                 


Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys 
225                 230                 235                 240 


Val Asn Phe Gly Ser Gly Ser Gly Tyr Ile Pro Glu Ala Pro Arg Asp 
                245                 250                 255     


Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr 
            260                 265                 270         


Phe Leu Gly 
        275 


<210>  9
<211>  275
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  RBD-foldon-P2

<400>  9

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Gly 
    210                 215                 220                 


Ser Gly Ser Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr 
225                 230                 235                 240 


Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly Gly 
                245                 250                 255     


Ser Gly Ser Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile 
            260                 265                 270         


Thr Glu Leu 
        275 


<210>  10
<211>  431
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  RBD-P2-ferritin LC

<400>  10

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Gly 
    210                 215                 220                 


Ser Gly Ser Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile 
225                 230                 235                 240 


Thr Glu Leu Gly Ser Gly Ser Gly Glu Tyr Gly Ser His Gly Asn Val 
                245                 250                 255     


Ala Thr Glu Leu Gln Ala Tyr Ala Lys Leu His Leu Glu Arg Ser Tyr 
            260                 265                 270         


Asp Tyr Leu Leu Ser Ala Ala Tyr Phe Asn Asn Tyr Gln Thr Asn Arg 
        275                 280                 285             


Ala Gly Phe Ser Lys Leu Phe Lys Lys Leu Ser Asp Glu Ala Trp Ser 
    290                 295                 300                 


Lys Thr Ile Asp Ile Ile Lys His Val Thr Lys Arg Gly Asp Lys Met 
305                 310                 315                 320 


Asn Phe Asp Gln His Ser Thr Met Lys Thr Glu Arg Lys Asn Tyr Thr 
                325                 330                 335     


Ala Glu Asn His Glu Leu Glu Ala Leu Ala Lys Ala Leu Asp Thr Gln 
            340                 345                 350         


Lys Glu Leu Ala Glu Arg Ala Phe Tyr Ile His Arg Glu Ala Thr Arg 
        355                 360                 365             


Asn Ser Gln His Leu His Asp Pro Glu Ile Ala Gln Tyr Leu Glu Glu 
    370                 375                 380                 


Glu Phe Ile Glu Asp His Ala Glu Lys Ile Arg Thr Leu Ala Gly His 
385                 390                 395                 400 


Thr Ser Asp Leu Lys Lys Phe Ile Thr Ala Asn Asn Gly His Asp Leu 
                405                 410                 415     


Ser Leu Ala Leu Tyr Val Phe Asp Glu Tyr Leu Gln Lys Thr Val 
            420                 425                 430     


<210>  11
<211>  429
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  RBD-P2-ferritin HC

<400>  11

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Gly 
    210                 215                 220                 


Ser Gly Ser Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile 
225                 230                 235                 240 


Thr Glu Leu Gly Ser Gly Ser Gly Arg Ser Cys Arg Asn Ser Met Arg 
                245                 250                 255     


Gln Gln Ile Gln Met Glu Val Gly Ala Ser Leu Gln Tyr Leu Ala Met 
            260                 265                 270         


Gly Ala His Phe Ser Lys Asp Val Val Asn Arg Pro Gly Phe Ala Gln 
        275                 280                 285             


Leu Phe Phe Asp Ala Ala Ser Glu Glu Arg Glu His Ala Met Lys Leu 
    290                 295                 300                 


Ile Glu Tyr Leu Leu Met Arg Gly Glu Leu Thr Asn Asp Val Ser Ser 
305                 310                 315                 320 


Leu Leu Gln Val Arg Pro Pro Thr Arg Ser Ser Trp Lys Gly Gly Val 
                325                 330                 335     


Glu Ala Leu Glu His Ala Leu Ser Met Glu Ser Asp Val Thr Lys Ser 
            340                 345                 350         


Ile Arg Asn Val Ile Lys Ala Cys Glu Asp Asp Ser Glu Phe Asn Asp 
        355                 360                 365             


Tyr His Leu Val Asp Tyr Leu Thr Gly Asp Phe Leu Glu Glu Gln Tyr 
    370                 375                 380                 


Lys Gly Gln Arg Asp Leu Ala Gly Lys Ala Ser Thr Leu Lys Lys Leu 
385                 390                 395                 400 


Met Asp Arg His Glu Ala Leu Gly Glu Phe Ile Phe Asp Lys Lys Leu 
                405                 410                 415     


Leu Gly Ile Asp Val Asp Tyr Lys Asp Asp Asp Asp Lys 
            420                 425                 


<210>  12
<211>  431
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  P2-RBD-ferritin LC

<400>  12

Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Gly 
1               5                   10                  15      


Ser Gly Ser Gly Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro 
            20                  25                  30          


Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
        35                  40                  45              


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
    50                  55                  60                  


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
65                  70                  75                  80  


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
                85                  90                  95      


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
            100                 105                 110         


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
        115                 120                 125             


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
    130                 135                 140                 


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
145                 150                 155                 160 


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
                165                 170                 175     


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
            180                 185                 190         


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
        195                 200                 205             


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
    210                 215                 220                 


Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys 
225                 230                 235                 240 


Val Asn Phe Gly Ser Gly Ser Gly Glu Tyr Gly Ser His Gly Asn Val 
                245                 250                 255     


Ala Thr Glu Leu Gln Ala Tyr Ala Lys Leu His Leu Glu Arg Ser Tyr 
            260                 265                 270         


Asp Tyr Leu Leu Ser Ala Ala Tyr Phe Asn Asn Tyr Gln Thr Asn Arg 
        275                 280                 285             


Ala Gly Phe Ser Lys Leu Phe Lys Lys Leu Ser Asp Glu Ala Trp Ser 
    290                 295                 300                 


Lys Thr Ile Asp Ile Ile Lys His Val Thr Lys Arg Gly Asp Lys Met 
305                 310                 315                 320 


Asn Phe Asp Gln His Ser Thr Met Lys Thr Glu Arg Lys Asn Tyr Thr 
                325                 330                 335     


Ala Glu Asn His Glu Leu Glu Ala Leu Ala Lys Ala Leu Asp Thr Gln 
            340                 345                 350         


Lys Glu Leu Ala Glu Arg Ala Phe Tyr Ile His Arg Glu Ala Thr Arg 
        355                 360                 365             


Asn Ser Gln His Leu His Asp Pro Glu Ile Ala Gln Tyr Leu Glu Glu 
    370                 375                 380                 


Glu Phe Ile Glu Asp His Ala Glu Lys Ile Arg Thr Leu Ala Gly His 
385                 390                 395                 400 


Thr Ser Asp Leu Lys Lys Phe Ile Thr Ala Asn Asn Gly His Asp Leu 
                405                 410                 415     


Ser Leu Ala Leu Tyr Val Phe Asp Glu Tyr Leu Gln Lys Thr Val 
            420                 425                 430     


<210>  13
<211>  429
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  P2-RBD-ferritin HC

<400>  13

Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Gly 
1               5                   10                  15      


Ser Gly Ser Gly Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro 
            20                  25                  30          


Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
        35                  40                  45              


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
    50                  55                  60                  


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
65                  70                  75                  80  


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
                85                  90                  95      


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
            100                 105                 110         


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
        115                 120                 125             


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
    130                 135                 140                 


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
145                 150                 155                 160 


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
                165                 170                 175     


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
            180                 185                 190         


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
        195                 200                 205             


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
    210                 215                 220                 


Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys 
225                 230                 235                 240 


Val Asn Phe Gly Ser Gly Ser Gly Arg Ser Cys Arg Asn Ser Met Arg 
                245                 250                 255     


Gln Gln Ile Gln Met Glu Val Gly Ala Ser Leu Gln Tyr Leu Ala Met 
            260                 265                 270         


Gly Ala His Phe Ser Lys Asp Val Val Asn Arg Pro Gly Phe Ala Gln 
        275                 280                 285             


Leu Phe Phe Asp Ala Ala Ser Glu Glu Arg Glu His Ala Met Lys Leu 
    290                 295                 300                 


Ile Glu Tyr Leu Leu Met Arg Gly Glu Leu Thr Asn Asp Val Ser Ser 
305                 310                 315                 320 


Leu Leu Gln Val Arg Pro Pro Thr Arg Ser Ser Trp Lys Gly Gly Val 
                325                 330                 335     


Glu Ala Leu Glu His Ala Leu Ser Met Glu Ser Asp Val Thr Lys Ser 
            340                 345                 350         


Ile Arg Asn Val Ile Lys Ala Cys Glu Asp Asp Ser Glu Phe Asn Asp 
        355                 360                 365             


Tyr His Leu Val Asp Tyr Leu Thr Gly Asp Phe Leu Glu Glu Gln Tyr 
    370                 375                 380                 


Lys Gly Gln Arg Asp Leu Ala Gly Lys Ala Ser Thr Leu Lys Lys Leu 
385                 390                 395                 400 


Met Asp Arg His Glu Ala Leu Gly Glu Phe Ile Phe Asp Lys Lys Leu 
                405                 410                 415     


Leu Gly Ile Asp Val Asp Tyr Lys Asp Asp Asp Asp Lys 
            420                 425                 


<210>  14
<211>  411
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  P2-RBD-ferritin

<400>  14

Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Gly 
1               5                   10                  15      


Ser Gly Ser Gly Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro 
            20                  25                  30          


Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
        35                  40                  45              


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
    50                  55                  60                  


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
65                  70                  75                  80  


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
                85                  90                  95      


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
            100                 105                 110         


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
        115                 120                 125             


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
    130                 135                 140                 


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
145                 150                 155                 160 


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
                165                 170                 175     


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
            180                 185                 190         


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
        195                 200                 205             


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
    210                 215                 220                 


Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys 
225                 230                 235                 240 


Val Asn Phe Gly Ser Gly Ser Gly Asp Ile Ile Lys Leu Leu Asn Glu 
                245                 250                 255     


Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met Ser 
            260                 265                 270         


Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe 
        275                 280                 285             


Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe 
    290                 295                 300                 


Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro 
305                 310                 315                 320 


Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu 
                325                 330                 335     


His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala 
            340                 345                 350         


Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val 
        355                 360                 365             


Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys 
    370                 375                 380                 


Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln 
385                 390                 395                 400 


Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                405                 410     


<210>  15
<211>  474
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  RBD-P2-HBsAg

<400>  15

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Gly 
    210                 215                 220                 


Ser Gly Ser Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile 
225                 230                 235                 240 


Thr Glu Leu Gly Ser Gly Ser Gly Met Glu Asn Ile Thr Ser Gly Phe 
                245                 250                 255     


Leu Gly Pro Leu Leu Val Leu Gln Ala Gly Phe Phe Leu Leu Thr Arg 
            260                 265                 270         


Ile Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn 
        275                 280                 285             


Phe Leu Gly Gly Ser Pro Val Cys Leu Gly Gln Asn Ser Gln Ser Pro 
    290                 295                 300                 


Thr Ser Asn His Ser Pro Thr Ser Cys Pro Pro Ile Cys Pro Gly Tyr 
305                 310                 315                 320 


Arg Trp Met Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu 
                325                 330                 335     


Leu Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu 
            340                 345                 350         


Pro Val Cys Pro Leu Ile Pro Gly Ser Thr Thr Thr Ser Thr Gly Pro 
        355                 360                 365             


Cys Lys Thr Cys Thr Thr Pro Ala Gln Gly Asn Ser Met Phe Pro Ser 
    370                 375                 380                 


Cys Cys Cys Thr Lys Pro Thr Asp Gly Asn Cys Thr Cys Ile Pro Ile 
385                 390                 395                 400 


Pro Ser Ser Trp Ala Phe Ala Lys Tyr Leu Trp Glu Trp Ala Ser Val 
                405                 410                 415     


Arg Phe Ser Trp Leu Ser Leu Leu Val Pro Phe Val Gln Trp Phe Val 
            420                 425                 430         


Gly Leu Ser Pro Thr Val Trp Leu Ser Ala Ile Trp Met Met Trp Tyr 
        435                 440                 445             


Trp Gly Pro Ser Leu Tyr Ser Ile Val Ser Pro Phe Ile Pro Leu Leu 
    450                 455                 460                 


Pro Ile Phe Phe Cys Leu Trp Val Tyr Ile 
465                 470                 


<210>  16
<211>  474
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  P2-RBD-HBsAg

<400>  16

Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Gly 
1               5                   10                  15      


Ser Gly Ser Gly Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro 
            20                  25                  30          


Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
        35                  40                  45              


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
    50                  55                  60                  


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
65                  70                  75                  80  


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
                85                  90                  95      


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
            100                 105                 110         


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
        115                 120                 125             


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
    130                 135                 140                 


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
145                 150                 155                 160 


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
                165                 170                 175     


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
            180                 185                 190         


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
        195                 200                 205             


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
    210                 215                 220                 


Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys 
225                 230                 235                 240 


Val Asn Phe Gly Ser Gly Ser Gly Met Glu Asn Ile Thr Ser Gly Phe 
                245                 250                 255     


Leu Gly Pro Leu Leu Val Leu Gln Ala Gly Phe Phe Leu Leu Thr Arg 
            260                 265                 270         


Ile Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn 
        275                 280                 285             


Phe Leu Gly Gly Ser Pro Val Cys Leu Gly Gln Asn Ser Gln Ser Pro 
    290                 295                 300                 


Thr Ser Asn His Ser Pro Thr Ser Cys Pro Pro Ile Cys Pro Gly Tyr 
305                 310                 315                 320 


Arg Trp Met Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu 
                325                 330                 335     


Leu Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu 
            340                 345                 350         


Pro Val Cys Pro Leu Ile Pro Gly Ser Thr Thr Thr Ser Thr Gly Pro 
        355                 360                 365             


Cys Lys Thr Cys Thr Thr Pro Ala Gln Gly Asn Ser Met Phe Pro Ser 
    370                 375                 380                 


Cys Cys Cys Thr Lys Pro Thr Asp Gly Asn Cys Thr Cys Ile Pro Ile 
385                 390                 395                 400 


Pro Ser Ser Trp Ala Phe Ala Lys Tyr Leu Trp Glu Trp Ala Ser Val 
                405                 410                 415     


Arg Phe Ser Trp Leu Ser Leu Leu Val Pro Phe Val Gln Trp Phe Val 
            420                 425                 430         


Gly Leu Ser Pro Thr Val Trp Leu Ser Ala Ile Trp Met Met Trp Tyr 
        435                 440                 445             


Trp Gly Pro Ser Leu Tyr Ser Ile Val Ser Pro Phe Ile Pro Leu Leu 
    450                 455                 460                 


Pro Ile Phe Phe Cys Leu Trp Val Tyr Ile 
465                 470                 


<210>  17
<211>  474
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  RBD-HBsAg-P2

<400>  17

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Gly 
    210                 215                 220                 


Ser Gly Ser Gly Met Glu Asn Ile Thr Ser Gly Phe Leu Gly Pro Leu 
225                 230                 235                 240 


Leu Val Leu Gln Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile 
                245                 250                 255     


Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly 
            260                 265                 270         


Ser Pro Val Cys Leu Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn His 
        275                 280                 285             


Ser Pro Thr Ser Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met Cys 
    290                 295                 300                 


Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile 
305                 310                 315                 320 


Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro 
                325                 330                 335     


Leu Ile Pro Gly Ser Thr Thr Thr Ser Thr Gly Pro Cys Lys Thr Cys 
            340                 345                 350         


Thr Thr Pro Ala Gln Gly Asn Ser Met Phe Pro Ser Cys Cys Cys Thr 
        355                 360                 365             


Lys Pro Thr Asp Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp 
    370                 375                 380                 


Ala Phe Ala Lys Tyr Leu Trp Glu Trp Ala Ser Val Arg Phe Ser Trp 
385                 390                 395                 400 


Leu Ser Leu Leu Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro 
                405                 410                 415     


Thr Val Trp Leu Ser Ala Ile Trp Met Met Trp Tyr Trp Gly Pro Ser 
            420                 425                 430         


Leu Tyr Ser Ile Val Ser Pro Phe Ile Pro Leu Leu Pro Ile Phe Phe 
        435                 440                 445             


Cys Leu Trp Val Tyr Ile Gly Ser Gly Ser Gly Gln Tyr Ile Lys Ala 
    450                 455                 460                 


Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu 
465                 470                 


<210>  18
<211>  223
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  RBD 319-541

<400>  18

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
    210                 215                 220             


<210>  19
<211>  194
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  RBD 331-524

<400>  19

Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
            180                 185                 190         


Thr Val 
        


<210>  20
<211>  311
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  NTD-P2

<400>  20

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Gly Ser Gly Ser Gly Gln Tyr Ile Lys Ala Asn Ser Lys 
    290                 295                 300                 


Phe Ile Gly Ile Thr Glu Leu 
305                 310     


<210>  21
<211>  311
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  P2-NTD

<400>  21

Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Gly 
1               5                   10                  15      


Ser Gly Ser Gly Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro 
            20                  25                  30          


Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys 
        35                  40                  45              


Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro 
    50                  55                  60                  


Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr 
65                  70                  75                  80  


Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly 
                85                  90                  95      


Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile 
            100                 105                 110         


Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn 
        115                 120                 125             


Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn 
    130                 135                 140                 


Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met 
145                 150                 155                 160 


Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu 
                165                 170                 175     


Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn 
            180                 185                 190         


Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe 
        195                 200                 205             


Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro 
    210                 215                 220                 


Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile 
225                 230                 235                 240 


Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu 
                245                 250                 255     


Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr 
            260                 265                 270         


Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu 
        275                 280                 285             


Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser 
    290                 295                 300                 


Glu Thr Lys Cys Thr Leu Lys 
305                 310     


<210>  22
<211>  323
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  NTD-foldon

<400>  22

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Gly Ser Gly Ser Gly Tyr Ile Pro Glu Ala Pro Arg Asp 
    290                 295                 300                 


Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr 
305                 310                 315                 320 


Phe Leu Gly 
            


<210>  23
<211>  478
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  NTD-ferritin LC

<400>  23

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Gly Ser Gly Ser Gly Glu Tyr Gly Ser His Gly Asn Val Ala 
    290                 295                 300                 


Thr Glu Leu Gln Ala Tyr Ala Lys Leu His Leu Glu Arg Ser Tyr Asp 
305                 310                 315                 320 


Tyr Leu Leu Ser Ala Ala Tyr Phe Asn Asn Tyr Gln Thr Asn Arg Ala 
                325                 330                 335     


Gly Phe Ser Lys Leu Phe Lys Lys Leu Ser Asp Glu Ala Trp Ser Lys 
            340                 345                 350         


Thr Ile Asp Ile Ile Lys His Val Thr Lys Arg Gly Asp Lys Met Asn 
        355                 360                 365             


Phe Asp Gln His Ser Thr Met Lys Thr Glu Arg Lys Asn Tyr Thr Ala 
    370                 375                 380                 


Glu Asn His Glu Leu Glu Ala Leu Ala Lys Ala Leu Asp Thr Gln Lys 
385                 390                 395                 400 


Glu Leu Ala Glu Arg Ala Phe Tyr Ile His Arg Glu Ala Thr Arg Asn 
                405                 410                 415     


Ser Gln His Leu His Asp Pro Glu Ile Ala Gln Tyr Leu Glu Glu Glu 
            420                 425                 430         


Phe Ile Glu Asp His Ala Glu Lys Ile Arg Thr Leu Ala Gly His Thr 
        435                 440                 445             


Ser Asp Leu Lys Lys Phe Ile Thr Ala Asn Asn Gly His Asp Leu Ser 
    450                 455                 460                 


Leu Ala Leu Tyr Val Phe Asp Glu Tyr Leu Gln Lys Thr Val 
465                 470                 475             


<210>  24
<211>  476
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  NTD-ferritin HC

<400>  24

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Gly Ser Gly Ser Gly Arg Ser Cys Arg Asn Ser Met Arg Gln 
    290                 295                 300                 


Gln Ile Gln Met Glu Val Gly Ala Ser Leu Gln Tyr Leu Ala Met Gly 
305                 310                 315                 320 


Ala His Phe Ser Lys Asp Val Val Asn Arg Pro Gly Phe Ala Gln Leu 
                325                 330                 335     


Phe Phe Asp Ala Ala Ser Glu Glu Arg Glu His Ala Met Lys Leu Ile 
            340                 345                 350         


Glu Tyr Leu Leu Met Arg Gly Glu Leu Thr Asn Asp Val Ser Ser Leu 
        355                 360                 365             


Leu Gln Val Arg Pro Pro Thr Arg Ser Ser Trp Lys Gly Gly Val Glu 
    370                 375                 380                 


Ala Leu Glu His Ala Leu Ser Met Glu Ser Asp Val Thr Lys Ser Ile 
385                 390                 395                 400 


Arg Asn Val Ile Lys Ala Cys Glu Asp Asp Ser Glu Phe Asn Asp Tyr 
                405                 410                 415     


His Leu Val Asp Tyr Leu Thr Gly Asp Phe Leu Glu Glu Gln Tyr Lys 
            420                 425                 430         


Gly Gln Arg Asp Leu Ala Gly Lys Ala Ser Thr Leu Lys Lys Leu Met 
        435                 440                 445             


Asp Arg His Glu Ala Leu Gly Glu Phe Ile Phe Asp Lys Lys Leu Leu 
    450                 455                 460                 


Gly Ile Asp Val Asp Tyr Lys Asp Asp Asp Asp Lys 
465                 470                 475     


<210>  25
<211>  521
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  NTD-HBsAg

<400>  25

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Gly Ser Gly Ser Gly Met Glu Asn Ile Thr Ser Gly Phe Leu 
    290                 295                 300                 


Gly Pro Leu Leu Val Leu Gln Ala Gly Phe Phe Leu Leu Thr Arg Ile 
305                 310                 315                 320 


Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe 
                325                 330                 335     


Leu Gly Gly Ser Pro Val Cys Leu Gly Gln Asn Ser Gln Ser Pro Thr 
            340                 345                 350         


Ser Asn His Ser Pro Thr Ser Cys Pro Pro Ile Cys Pro Gly Tyr Arg 
        355                 360                 365             


Trp Met Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu 
    370                 375                 380                 


Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu Pro 
385                 390                 395                 400 


Val Cys Pro Leu Ile Pro Gly Ser Thr Thr Thr Ser Thr Gly Pro Cys 
                405                 410                 415     


Lys Thr Cys Thr Thr Pro Ala Gln Gly Asn Ser Met Phe Pro Ser Cys 
            420                 425                 430         


Cys Cys Thr Lys Pro Thr Asp Gly Asn Cys Thr Cys Ile Pro Ile Pro 
        435                 440                 445             


Ser Ser Trp Ala Phe Ala Lys Tyr Leu Trp Glu Trp Ala Ser Val Arg 
    450                 455                 460                 


Phe Ser Trp Leu Ser Leu Leu Val Pro Phe Val Gln Trp Phe Val Gly 
465                 470                 475                 480 


Leu Ser Pro Thr Val Trp Leu Ser Ala Ile Trp Met Met Trp Tyr Trp 
                485                 490                 495     


Gly Pro Ser Leu Tyr Ser Ile Val Ser Pro Phe Ile Pro Leu Leu Pro 
            500                 505                 510         


Ile Phe Phe Cys Leu Trp Val Tyr Ile 
        515                 520     


<210>  26
<211>  342
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  NTD-P2-foldon

<400>  26

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Gly Ser Gly Ser Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe 
    290                 295                 300                 


Ile Gly Ile Thr Glu Leu Gly Ser Gly Ser Gly Tyr Ile Pro Glu Ala 
305                 310                 315                 320 


Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu 
                325                 330                 335     


Leu Ser Thr Phe Leu Gly 
            340         


<210>  27
<211>  342
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  P2-NTD-foldon

<400>  27

Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Gly 
1               5                   10                  15      


Ser Gly Ser Gly Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro 
            20                  25                  30          


Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys 
        35                  40                  45              


Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro 
    50                  55                  60                  


Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr 
65                  70                  75                  80  


Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly 
                85                  90                  95      


Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile 
            100                 105                 110         


Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn 
        115                 120                 125             


Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn 
    130                 135                 140                 


Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met 
145                 150                 155                 160 


Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu 
                165                 170                 175     


Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn 
            180                 185                 190         


Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe 
        195                 200                 205             


Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro 
    210                 215                 220                 


Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile 
225                 230                 235                 240 


Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu 
                245                 250                 255     


Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr 
            260                 265                 270         


Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu 
        275                 280                 285             


Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser 
    290                 295                 300                 


Glu Thr Lys Cys Thr Leu Gly Ser Gly Ser Gly Tyr Ile Pro Glu Ala 
305                 310                 315                 320 


Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu 
                325                 330                 335     


Leu Ser Thr Phe Leu Gly 
            340         


<210>  28
<211>  342
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  NTD-foldon-P2

<400>  28

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Gly Ser Gly Ser Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly 
    290                 295                 300                 


Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe 
305                 310                 315                 320 


Leu Gly Gly Ser Gly Ser Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe 
                325                 330                 335     


Ile Gly Ile Thr Glu Leu 
            340         


<210>  29
<211>  498
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  NTD-P2-ferritin LC

<400>  29

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Gly Ser Gly Ser Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe 
    290                 295                 300                 


Ile Gly Ile Thr Glu Leu Gly Ser Gly Ser Gly Glu Tyr Gly Ser His 
305                 310                 315                 320 


Gly Asn Val Ala Thr Glu Leu Gln Ala Tyr Ala Lys Leu His Leu Glu 
                325                 330                 335     


Arg Ser Tyr Asp Tyr Leu Leu Ser Ala Ala Tyr Phe Asn Asn Tyr Gln 
            340                 345                 350         


Thr Asn Arg Ala Gly Phe Ser Lys Leu Phe Lys Lys Leu Ser Asp Glu 
        355                 360                 365             


Ala Trp Ser Lys Thr Ile Asp Ile Ile Lys His Val Thr Lys Arg Gly 
    370                 375                 380                 


Asp Lys Met Asn Phe Asp Gln His Ser Thr Met Lys Thr Glu Arg Lys 
385                 390                 395                 400 


Asn Tyr Thr Ala Glu Asn His Glu Leu Glu Ala Leu Ala Lys Ala Leu 
                405                 410                 415     


Asp Thr Gln Lys Glu Leu Ala Glu Arg Ala Phe Tyr Ile His Arg Glu 
            420                 425                 430         


Ala Thr Arg Asn Ser Gln His Leu His Asp Pro Glu Ile Ala Gln Tyr 
        435                 440                 445             


Leu Glu Glu Glu Phe Ile Glu Asp His Ala Glu Lys Ile Arg Thr Leu 
    450                 455                 460                 


Ala Gly His Thr Ser Asp Leu Lys Lys Phe Ile Thr Ala Asn Asn Gly 
465                 470                 475                 480 


His Asp Leu Ser Leu Ala Leu Tyr Val Phe Asp Glu Tyr Leu Gln Lys 
                485                 490                 495     


Thr Val 
        


<210>  30
<211>  488
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  NTD-P2-ferritin HC

<400>  30

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Gly Ser Gly Ser Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe 
    290                 295                 300                 


Ile Gly Ile Thr Glu Leu Gly Ser Gly Ser Gly Arg Ser Cys Arg Asn 
305                 310                 315                 320 


Ser Met Arg Gln Gln Ile Gln Met Glu Val Gly Ala Ser Leu Gln Tyr 
                325                 330                 335     


Leu Ala Met Gly Ala His Phe Ser Lys Asp Val Val Asn Arg Pro Gly 
            340                 345                 350         


Phe Ala Gln Leu Phe Phe Asp Ala Ala Ser Glu Glu Arg Glu His Ala 
        355                 360                 365             


Met Lys Leu Ile Glu Tyr Leu Leu Met Arg Gly Glu Leu Thr Asn Asp 
    370                 375                 380                 


Val Ser Ser Leu Leu Gln Val Arg Pro Pro Thr Arg Ser Ser Trp Lys 
385                 390                 395                 400 


Gly Gly Val Glu Ala Leu Glu His Ala Leu Ser Met Glu Ser Asp Val 
                405                 410                 415     


Thr Lys Ser Ile Arg Asn Val Ile Lys Ala Cys Glu Asp Asp Ser Glu 
            420                 425                 430         


Phe Asn Asp Tyr His Leu Val Asp Tyr Leu Thr Gly Asp Phe Leu Glu 
        435                 440                 445             


Glu Gln Tyr Lys Gly Gln Arg Asp Leu Ala Gly Lys Ala Ser Thr Leu 
    450                 455                 460                 


Lys Lys Leu Met Asp Arg His Glu Ala Leu Gly Glu Phe Ile Phe Asp 
465                 470                 475                 480 


Lys Lys Leu Leu Gly Ile Asp Val 
                485             


<210>  31
<211>  498
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  P2-NTD-ferritin LC

<400>  31

Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Gly 
1               5                   10                  15      


Ser Gly Ser Gly Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro 
            20                  25                  30          


Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys 
        35                  40                  45              


Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro 
    50                  55                  60                  


Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr 
65                  70                  75                  80  


Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly 
                85                  90                  95      


Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile 
            100                 105                 110         


Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn 
        115                 120                 125             


Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn 
    130                 135                 140                 


Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met 
145                 150                 155                 160 


Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu 
                165                 170                 175     


Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn 
            180                 185                 190         


Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe 
        195                 200                 205             


Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro 
    210                 215                 220                 


Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile 
225                 230                 235                 240 


Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu 
                245                 250                 255     


Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr 
            260                 265                 270         


Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu 
        275                 280                 285             


Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser 
    290                 295                 300                 


Glu Thr Lys Cys Thr Leu Gly Ser Gly Ser Gly Glu Tyr Gly Ser His 
305                 310                 315                 320 


Gly Asn Val Ala Thr Glu Leu Gln Ala Tyr Ala Lys Leu His Leu Glu 
                325                 330                 335     


Arg Ser Tyr Asp Tyr Leu Leu Ser Ala Ala Tyr Phe Asn Asn Tyr Gln 
            340                 345                 350         


Thr Asn Arg Ala Gly Phe Ser Lys Leu Phe Lys Lys Leu Ser Asp Glu 
        355                 360                 365             


Ala Trp Ser Lys Thr Ile Asp Ile Ile Lys His Val Thr Lys Arg Gly 
    370                 375                 380                 


Asp Lys Met Asn Phe Asp Gln His Ser Thr Met Lys Thr Glu Arg Lys 
385                 390                 395                 400 


Asn Tyr Thr Ala Glu Asn His Glu Leu Glu Ala Leu Ala Lys Ala Leu 
                405                 410                 415     


Asp Thr Gln Lys Glu Leu Ala Glu Arg Ala Phe Tyr Ile His Arg Glu 
            420                 425                 430         


Ala Thr Arg Asn Ser Gln His Leu His Asp Pro Glu Ile Ala Gln Tyr 
        435                 440                 445             


Leu Glu Glu Glu Phe Ile Glu Asp His Ala Glu Lys Ile Arg Thr Leu 
    450                 455                 460                 


Ala Gly His Thr Ser Asp Leu Lys Lys Phe Ile Thr Ala Asn Asn Gly 
465                 470                 475                 480 


His Asp Leu Ser Leu Ala Leu Tyr Val Phe Asp Glu Tyr Leu Gln Lys 
                485                 490                 495     


Thr Val 
        


<210>  32
<211>  488
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  P2-NTD-ferritin HC

<400>  32

Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Gly 
1               5                   10                  15      


Ser Gly Ser Gly Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro 
            20                  25                  30          


Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys 
        35                  40                  45              


Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro 
    50                  55                  60                  


Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr 
65                  70                  75                  80  


Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly 
                85                  90                  95      


Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile 
            100                 105                 110         


Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn 
        115                 120                 125             


Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn 
    130                 135                 140                 


Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met 
145                 150                 155                 160 


Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu 
                165                 170                 175     


Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn 
            180                 185                 190         


Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe 
        195                 200                 205             


Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro 
    210                 215                 220                 


Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile 
225                 230                 235                 240 


Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu 
                245                 250                 255     


Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr 
            260                 265                 270         


Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu 
        275                 280                 285             


Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser 
    290                 295                 300                 


Glu Thr Lys Cys Thr Leu Gly Ser Gly Ser Gly Arg Ser Cys Arg Asn 
305                 310                 315                 320 


Ser Met Arg Gln Gln Ile Gln Met Glu Val Gly Ala Ser Leu Gln Tyr 
                325                 330                 335     


Leu Ala Met Gly Ala His Phe Ser Lys Asp Val Val Asn Arg Pro Gly 
            340                 345                 350         


Phe Ala Gln Leu Phe Phe Asp Ala Ala Ser Glu Glu Arg Glu His Ala 
        355                 360                 365             


Met Lys Leu Ile Glu Tyr Leu Leu Met Arg Gly Glu Leu Thr Asn Asp 
    370                 375                 380                 


Val Ser Ser Leu Leu Gln Val Arg Pro Pro Thr Arg Ser Ser Trp Lys 
385                 390                 395                 400 


Gly Gly Val Glu Ala Leu Glu His Ala Leu Ser Met Glu Ser Asp Val 
                405                 410                 415     


Thr Lys Ser Ile Arg Asn Val Ile Lys Ala Cys Glu Asp Asp Ser Glu 
            420                 425                 430         


Phe Asn Asp Tyr His Leu Val Asp Tyr Leu Thr Gly Asp Phe Leu Glu 
        435                 440                 445             


Glu Gln Tyr Lys Gly Gln Arg Asp Leu Ala Gly Lys Ala Ser Thr Leu 
    450                 455                 460                 


Lys Lys Leu Met Asp Arg His Glu Ala Leu Gly Glu Phe Ile Phe Asp 
465                 470                 475                 480 


Lys Lys Leu Leu Gly Ile Asp Val 
                485             


<210>  33
<211>  478
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  P2-NTD-ferritin

<400>  33

Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Gly 
1               5                   10                  15      


Ser Gly Ser Gly Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro 
            20                  25                  30          


Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys 
        35                  40                  45              


Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro 
    50                  55                  60                  


Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr 
65                  70                  75                  80  


Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly 
                85                  90                  95      


Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile 
            100                 105                 110         


Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn 
        115                 120                 125             


Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn 
    130                 135                 140                 


Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met 
145                 150                 155                 160 


Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu 
                165                 170                 175     


Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn 
            180                 185                 190         


Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe 
        195                 200                 205             


Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro 
    210                 215                 220                 


Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile 
225                 230                 235                 240 


Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu 
                245                 250                 255     


Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr 
            260                 265                 270         


Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu 
        275                 280                 285             


Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser 
    290                 295                 300                 


Glu Thr Lys Cys Thr Leu Gly Ser Gly Ser Gly Asp Ile Ile Lys Leu 
305                 310                 315                 320 


Leu Asn Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr Met 
                325                 330                 335     


Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu 
            340                 345                 350         


Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu 
        355                 360                 365             


Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile 
    370                 375                 380                 


Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys 
385                 390                 395                 400 


Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val 
                405                 410                 415     


Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln 
            420                 425                 430         


Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile 
        435                 440                 445             


Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu 
    450                 455                 460                 


Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
465                 470                 475             


<210>  34
<211>  541
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  NTD-P2-HBsAg

<400>  34

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Gly Ser Gly Ser Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe 
    290                 295                 300                 


Ile Gly Ile Thr Glu Leu Gly Ser Gly Ser Gly Met Glu Asn Ile Thr 
305                 310                 315                 320 


Ser Gly Phe Leu Gly Pro Leu Leu Val Leu Gln Ala Gly Phe Phe Leu 
                325                 330                 335     


Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr 
            340                 345                 350         


Ser Leu Asn Phe Leu Gly Gly Ser Pro Val Cys Leu Gly Gln Asn Ser 
        355                 360                 365             


Gln Ser Pro Thr Ser Asn His Ser Pro Thr Ser Cys Pro Pro Ile Cys 
    370                 375                 380                 


Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe 
385                 390                 395                 400 


Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln 
                405                 410                 415     


Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Thr Thr Thr Ser 
            420                 425                 430         


Thr Gly Pro Cys Lys Thr Cys Thr Thr Pro Ala Gln Gly Asn Ser Met 
        435                 440                 445             


Phe Pro Ser Cys Cys Cys Thr Lys Pro Thr Asp Gly Asn Cys Thr Cys 
    450                 455                 460                 


Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala Lys Tyr Leu Trp Glu Trp 
465                 470                 475                 480 


Ala Ser Val Arg Phe Ser Trp Leu Ser Leu Leu Val Pro Phe Val Gln 
                485                 490                 495     


Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu Ser Ala Ile Trp Met 
            500                 505                 510         


Met Trp Tyr Trp Gly Pro Ser Leu Tyr Ser Ile Val Ser Pro Phe Ile 
        515                 520                 525             


Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val Tyr Ile 
    530                 535                 540     


<210>  35
<211>  541
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  P2-NTD-HBsAg

<400>  35

Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Gly 
1               5                   10                  15      


Ser Gly Ser Gly Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro 
            20                  25                  30          


Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys 
        35                  40                  45              


Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro 
    50                  55                  60                  


Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr 
65                  70                  75                  80  


Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly 
                85                  90                  95      


Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile 
            100                 105                 110         


Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn 
        115                 120                 125             


Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn 
    130                 135                 140                 


Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met 
145                 150                 155                 160 


Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu 
                165                 170                 175     


Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn 
            180                 185                 190         


Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe 
        195                 200                 205             


Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro 
    210                 215                 220                 


Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile 
225                 230                 235                 240 


Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu 
                245                 250                 255     


Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr 
            260                 265                 270         


Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu 
        275                 280                 285             


Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser 
    290                 295                 300                 


Glu Thr Lys Cys Thr Leu Gly Ser Gly Ser Gly Met Glu Asn Ile Thr 
305                 310                 315                 320 


Ser Gly Phe Leu Gly Pro Leu Leu Val Leu Gln Ala Gly Phe Phe Leu 
                325                 330                 335     


Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr 
            340                 345                 350         


Ser Leu Asn Phe Leu Gly Gly Ser Pro Val Cys Leu Gly Gln Asn Ser 
        355                 360                 365             


Gln Ser Pro Thr Ser Asn His Ser Pro Thr Ser Cys Pro Pro Ile Cys 
    370                 375                 380                 


Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe 
385                 390                 395                 400 


Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln 
                405                 410                 415     


Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Thr Thr Thr Ser 
            420                 425                 430         


Thr Gly Pro Cys Lys Thr Cys Thr Thr Pro Ala Gln Gly Asn Ser Met 
        435                 440                 445             


Phe Pro Ser Cys Cys Cys Thr Lys Pro Thr Asp Gly Asn Cys Thr Cys 
    450                 455                 460                 


Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala Lys Tyr Leu Trp Glu Trp 
465                 470                 475                 480 


Ala Ser Val Arg Phe Ser Trp Leu Ser Leu Leu Val Pro Phe Val Gln 
                485                 490                 495     


Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu Ser Ala Ile Trp Met 
            500                 505                 510         


Met Trp Tyr Trp Gly Pro Ser Leu Tyr Ser Ile Val Ser Pro Phe Ile 
        515                 520                 525             


Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val Tyr Ile 
    530                 535                 540     


<210>  36
<211>  541
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  NTD-HBsAg-P2

<400>  36

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Gly Ser Gly Ser Gly Met Glu Asn Ile Thr Ser Gly Phe Leu 
    290                 295                 300                 


Gly Pro Leu Leu Val Leu Gln Ala Gly Phe Phe Leu Leu Thr Arg Ile 
305                 310                 315                 320 


Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe 
                325                 330                 335     


Leu Gly Gly Ser Pro Val Cys Leu Gly Gln Asn Ser Gln Ser Pro Thr 
            340                 345                 350         


Ser Asn His Ser Pro Thr Ser Cys Pro Pro Ile Cys Pro Gly Tyr Arg 
        355                 360                 365             


Trp Met Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu 
    370                 375                 380                 


Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu Pro 
385                 390                 395                 400 


Val Cys Pro Leu Ile Pro Gly Ser Thr Thr Thr Ser Thr Gly Pro Cys 
                405                 410                 415     


Lys Thr Cys Thr Thr Pro Ala Gln Gly Asn Ser Met Phe Pro Ser Cys 
            420                 425                 430         


Cys Cys Thr Lys Pro Thr Asp Gly Asn Cys Thr Cys Ile Pro Ile Pro 
        435                 440                 445             


Ser Ser Trp Ala Phe Ala Lys Tyr Leu Trp Glu Trp Ala Ser Val Arg 
    450                 455                 460                 


Phe Ser Trp Leu Ser Leu Leu Val Pro Phe Val Gln Trp Phe Val Gly 
465                 470                 475                 480 


Leu Ser Pro Thr Val Trp Leu Ser Ala Ile Trp Met Met Trp Tyr Trp 
                485                 490                 495     


Gly Pro Ser Leu Tyr Ser Ile Val Ser Pro Phe Ile Pro Leu Leu Pro 
            500                 505                 510         


Ile Phe Phe Cys Leu Trp Val Tyr Ile Gly Ser Gly Ser Gly Gln Tyr 
        515                 520                 525             


Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu 
    530                 535                 540     


<210>  37
<211>  291
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  NTD 14-304

<400>  37

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys 
    290     


<210>  38
<211>  336
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  NTD 18-353

<400>  38

Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr 
1               5                   10                  15      


Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu His 
            20                  25                  30          


Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp Phe 
        35                  40                  45              


His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn 
    50                  55                  60                  


Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys 
65                  70                  75                  80  


Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys 
                85                  90                  95      


Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys 
            100                 105                 110         


Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr 
        115                 120                 125             


His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser 
    130                 135                 140                 


Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met 
145                 150                 155                 160 


Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val 
                165                 170                 175     


Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro 
            180                 185                 190         


Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro 
        195                 200                 205             


Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu 
    210                 215                 220                 


Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly 
225                 230                 235                 240 


Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg 
                245                 250                 255     


Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val 
            260                 265                 270         


Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser 
        275                 280                 285             


Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln 
    290                 295                 300                 


Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro 
305                 310                 315                 320 


Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp 
                325                 330                 335     


<210>  39
<211>  536
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  NTD-RBD-6His

<400>  39

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
                325                 330                 335     


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
            420                 425                 430         


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
        435                 440                 445             


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
    450                 455                 460                 


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
465                 470                 475                 480 


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
                485                 490                 495     


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
            500                 505                 510         


Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
        515                 520                 525             


Gly Ser His His His His His His 
    530                 535     


<210>  40
<211>  556
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  NTD-RBD-P2-6His

<400>  40

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
                325                 330                 335     


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
            420                 425                 430         


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
        435                 440                 445             


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
    450                 455                 460                 


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
465                 470                 475                 480 


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
                485                 490                 495     


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
            500                 505                 510         


Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
        515                 520                 525             


Gly Ser Gly Ser Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly 
    530                 535                 540                 


Ile Thr Glu Leu Gly Ser His His His His His His 
545                 550                 555     


<210>  41
<211>  588
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  NTD-RBD-foldon-6His

<400>  41

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro 
            20                  25                  30          


Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys 
        35                  40                  45              


Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro 
    50                  55                  60                  


Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr 
65                  70                  75                  80  


Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly 
                85                  90                  95      


Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile 
            100                 105                 110         


Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn 
        115                 120                 125             


Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn 
    130                 135                 140                 


Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met 
145                 150                 155                 160 


Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu 
                165                 170                 175     


Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn 
            180                 185                 190         


Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe 
        195                 200                 205             


Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro 
    210                 215                 220                 


Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile 
225                 230                 235                 240 


Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu 
                245                 250                 255     


Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr 
            260                 265                 270         


Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu 
        275                 280                 285             


Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser 
    290                 295                 300                 


Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr 
305                 310                 315                 320 


Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe 
                325                 330                 335     


Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr 
            340                 345                 350         


Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys 
        355                 360                 365             


Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe 
    370                 375                 380                 


Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr 
385                 390                 395                 400 


Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln 
                405                 410                 415     


Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu 
            420                 425                 430         


Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu 
        435                 440                 445             


Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg 
    450                 455                 460                 


Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr 
465                 470                 475                 480 


Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr 
                485                 490                 495     


Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr 
            500                 505                 510         


Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro 
        515                 520                 525             


Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys 
    530                 535                 540                 


Cys Val Asn Phe Gly Ser Gly Ser Gly Tyr Ile Pro Glu Ala Pro Arg 
545                 550                 555                 560 


Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser 
                565                 570                 575     


Thr Phe Leu Gly Gly Ser His His His His His His 
            580                 585             


<210>  42
<211>  608
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  NTD-RBD-P2-foldon-6His

<400>  42

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro 
            20                  25                  30          


Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys 
        35                  40                  45              


Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro 
    50                  55                  60                  


Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr 
65                  70                  75                  80  


Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly 
                85                  90                  95      


Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile 
            100                 105                 110         


Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn 
        115                 120                 125             


Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn 
    130                 135                 140                 


Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met 
145                 150                 155                 160 


Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu 
                165                 170                 175     


Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn 
            180                 185                 190         


Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe 
        195                 200                 205             


Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro 
    210                 215                 220                 


Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile 
225                 230                 235                 240 


Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu 
                245                 250                 255     


Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr 
            260                 265                 270         


Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu 
        275                 280                 285             


Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser 
    290                 295                 300                 


Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr 
305                 310                 315                 320 


Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe 
                325                 330                 335     


Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr 
            340                 345                 350         


Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys 
        355                 360                 365             


Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe 
    370                 375                 380                 


Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr 
385                 390                 395                 400 


Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln 
                405                 410                 415     


Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu 
            420                 425                 430         


Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu 
        435                 440                 445             


Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg 
    450                 455                 460                 


Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr 
465                 470                 475                 480 


Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr 
                485                 490                 495     


Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr 
            500                 505                 510         


Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro 
        515                 520                 525             


Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys 
    530                 535                 540                 


Cys Val Asn Phe Gly Ser Gly Ser Gly Gln Tyr Ile Lys Ala Asn Ser 
545                 550                 555                 560 


Lys Phe Ile Gly Ile Thr Glu Leu Gly Ser Gly Ser Gly Tyr Ile Pro 
                565                 570                 575     


Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp 
            580                 585                 590         


Val Leu Leu Ser Thr Phe Leu Gly Gly Ser His His His His His His 
        595                 600                 605             


<210>  43
<211>  695
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  NTD-RBD-ferritin

<400>  43

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
                325                 330                 335     


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
            420                 425                 430         


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
        435                 440                 445             


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
    450                 455                 460                 


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
465                 470                 475                 480 


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
                485                 490                 495     


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
            500                 505                 510         


Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
        515                 520                 525             


Met Leu Ser Lys Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys 
    530                 535                 540                 


Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr 
545                 550                 555                 560 


Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala 
                565                 570                 575     


Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn 
            580                 585                 590         


Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe 
        595                 600                 605             


Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His 
    610                 615                 620                 


Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys 
625                 630                 635                 640 


Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His 
                645                 650                 655     


Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile 
            660                 665                 670         


Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly 
        675                 680                 685             


Ile Ala Lys Ser Arg Lys Ser 
    690                 695 


<210>  44
<211>  759
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  NTD-RBD- HBsAg

<400>  44

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
                325                 330                 335     


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
            420                 425                 430         


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
        435                 440                 445             


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
    450                 455                 460                 


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
465                 470                 475                 480 


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
                485                 490                 495     


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
            500                 505                 510         


Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
        515                 520                 525             


Gly Ser Gly Ser Gly Met Glu Asn Ile Thr Ser Gly Phe Leu Gly Pro 
    530                 535                 540                 


Leu Leu Val Leu Gln Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr 
545                 550                 555                 560 


Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly 
                565                 570                 575     


Gly Ser Pro Val Cys Leu Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn 
            580                 585                 590         


His Ser Pro Thr Ser Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met 
        595                 600                 605             


Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu 
    610                 615                 620                 


Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys 
625                 630                 635                 640 


Pro Leu Ile Pro Gly Ser Thr Thr Thr Ser Thr Gly Pro Cys Lys Thr 
                645                 650                 655     


Cys Thr Thr Pro Ala Gln Gly Asn Ser Met Phe Pro Ser Cys Cys Cys 
            660                 665                 670         


Thr Lys Pro Thr Asp Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser 
        675                 680                 685             


Trp Ala Phe Ala Lys Tyr Leu Trp Glu Trp Ala Ser Val Arg Phe Ser 
    690                 695                 700                 


Trp Leu Ser Leu Leu Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser 
705                 710                 715                 720 


Pro Thr Val Trp Leu Ser Ala Ile Trp Met Met Trp Tyr Trp Gly Pro 
                725                 730                 735     


Ser Leu Tyr Ser Ile Val Ser Pro Phe Ile Pro Leu Leu Pro Ile Phe 
            740                 745                 750         


Phe Cys Leu Trp Val Tyr Ile 
        755                 


<210>  45
<211>  1500
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  RBD-HBsAg-6*HIS

<400>  45
ggatccgccg ccaccatggg cgtgcccgct gtgccagagg ccagctctcc taggtggggc       60

accctgctgc tggccatctt tctggccgcc agcagaggcc tggtggccgc tagagtgcag      120

cctaccgaga gcatcgtgcg gttcccaaac atcaccaacc tgtgtccttt cggcgaggtg      180

ttcaatgcca ccaggttcgc tagcgtgtat gcctggaaca ggaagaggat ctccaattgt      240

gtggctgact actccgtgct gtacaacagc gcttccttta gcaccttcaa gtgctacggc      300

gtgtccccca ccaagctgaa cgacttgtgc tttaccaacg tgtatgccga cagctttgtg      360

atcaggggcg acgaggtgcg gcagattgct cctggacaga ccggaaagat cgctgactat      420

aattacaagc tgcccgacga cttcaccggc tgcgttatcg cttggaatag caacaatctg      480

gattccaagg tgggcggcaa ttacaattat ctgtaccggc tgttcaggaa gtccaacctg      540

aagcccttcg agagggatat cagcaccgag atctatcagg ctggctccac cccctgtaac      600

ggcgttgaag gattcaattg ctacttcccc ctgcagagct acggctttca gcctaccaat      660

ggcgtgggct atcagcccta cagggtggtt gtgctgagct ttgagctgct gcacgctcct      720

gctaccgtgt gtggaccaaa gaagtccacc aacctggtga agaataagtg cgtgaatttt      780

ggatctggaa gcggaatgga gaacatcacc tccggcttcc tgggcccact gttggttctg      840

caggccggat tcttcctgct gaccagaatc ctgaccatcc cccagtccct ggacagctgg      900

tggacatctc tgaattttct gggcggctcc cccgtgtgcc tgggacagaa ctctcagagc      960

cccaccagca accactcccc aacaagctgc ccccctatct gtcccggata taggtggatg     1020

tgtctgaggc ggttcatcat cttcctgttt atcctgctgc tgtgcctgat cttcctgctg     1080

gtgctgctgg actaccaggg catgctgcca gtgtgccctc tgatcccagg ctctaccacc     1140

accagcaccg gaccttgtaa gacctgcacc acccctgccc agggaaatag catgtttcct     1200

tcctgttgct gcaccaagcc caccgatggc aactgcacct gtatccccat ccctagcagc     1260

tgggcctttg ctaagtacct gtgggagtgg gcttccgtgc ggtttagctg gctgtccctg     1320

ctggtgcctt tcgtgcagtg gttcgtgggc ctgagcccta cagtgtggct gtctgctatc     1380

tggatgatgt ggtattgggg ccctagcctg tacagcatcg tgtccccatt cattcctctg     1440

ctgcctatct ttttctgcct gtgggtgtat atccaccacc accaccatca ctgactcgag     1500


<210>  46
<211>  1644
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  NTD-HBsAg-6*HIS

<400>  46
ggatccgccg ccaccatgtt cgtgtttctg gtgctgctgc ccctggtgtc ctcccagtgt       60

gttaatctga ccaccaggac ccagctgcct cctgcttaca ccaattcctt taccaggggc      120

gtgtactacc ccgacaaggt gttcaggtcc tccgtgctgc acagcaccca ggatctgttc      180

ctgcctttct ttagcaacgt gacctggttc cacgctatcc acgtgagcgg caccaacgga      240

accaagagat tcgacaatcc cgtgctgccc ttcaacgatg gcgtgtactt cgccagcacc      300

gagaagagca acatcatccg gggctggatc ttcggcacca ccttggattc caagacccag      360

agcctgctga tcgtgaacaa cgctaccaac gtggtcatta aggtgtgtga gttccagttt      420

tgtaacgacc cctttctggg cgtgtattat cacaagaaca ataagtcctg gatggagagc      480

gagtttaggg tgtattcctc cgctaacaac tgcacctttg agtatgtgag ccagcctttt      540

ctgatggacc tggagggcaa gcagggcaat ttcaagaacc tgagggagtt cgtgtttaag      600

aacatcgatg gctactttaa gatctactcc aagcacaccc ctatcaacct ggtgcgggat      660

ctgcctcagg gctttagcgc tctggagcct ctggtggatc tgccaatcgg catcaatatc      720

acccggtttc agaccctgct ggctctgcac aggagctacc tgacccctgg agatagctcc      780

agcggctgga cagctggagc tgctgcttac tacgtgggct acctgcagcc cagaaccttt      840

ctgctgaagt acaatgagaa cggcaccatc accgacgccg tggattgcgc tctggaccct      900

ttgtccgaga ccaagtgtac cctgggatct ggaagcggaa tggagaacat cacctccggc      960

ttcctgggcc cactgttggt tctgcaggcc ggattcttcc tgctgaccag aatcctgacc     1020

atcccccagt ccctggacag ctggtggaca tctctgaatt ttctgggcgg ctcccccgtg     1080

tgcctgggac agaactctca gagccccacc agcaaccact ccccaacaag ctgcccccct     1140

atctgtcccg gatataggtg gatgtgtctg aggcggttca tcatcttcct gtttatcctg     1200

ctgctgtgcc tgatcttcct gctggtgctg ctggactacc agggcatgct gccagtgtgc     1260

cctctgatcc caggctctac caccaccagc accggacctt gtaagacctg caccacccct     1320

gcccagggaa atagcatgtt tccttcctgt tgctgcacca agcccaccga tggcaactgc     1380

acctgtatcc ccatccctag cagctgggcc tttgctaagt acctgtggga gtgggcttcc     1440

gtgcggttta gctggctgtc cctgctggtg cctttcgtgc agtggttcgt gggcctgagc     1500

cctacagtgt ggctgtctgc tatctggatg atgtggtatt ggggccctag cctgtacagc     1560

atcgtgtccc cattcattcc tctgctgcct atctttttct gcctgtgggt gtatatccac     1620

caccaccacc atcactgact cgag                                            1644


<210>  47
<211>  903
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  RBD-foldon-6*HIS

<400>  47
ggatccgccg ccaccatggg cgtgcccgct gtgccagagg ccagctctcc taggtggggc       60

accctgctgc tggccatctt tctggccgcc agcagaggcc tggtggccgc tagagtgcag      120

cctaccgaga gcatcgtgcg gttcccaaac atcaccaacc tgtgtccttt cggcgaggtg      180

ttcaatgcca ccaggttcgc tagcgtgtat gcctggaaca ggaagaggat ctccaattgt      240

gtggctgact actccgtgct gtacaacagc gcttccttta gcaccttcaa gtgctacggc      300

gtgtccccca ccaagctgaa cgacttgtgc tttaccaacg tgtatgccga cagctttgtg      360

atcaggggcg acgaggtgcg gcagattgct cctggacaga ccggaaagat cgctgactat      420

aattacaagc tgcccgacga cttcaccggc tgcgttatcg cttggaatag caacaatctg      480

gattccaagg tgggcggcaa ttacaattat ctgtaccggc tgttcaggaa gtccaacctg      540

aagcccttcg agagggatat cagcaccgag atctatcagg ctggctccac cccctgtaac      600

ggcgttgaag gattcaattg ctacttcccc ctgcagagct acggctttca gcctaccaat      660

ggcgtgggct atcagcccta cagggtggtt gtgctgagct ttgagctgct gcacgctcct      720

gctaccgtgt gtggaccaaa gaagtccacc aacctggtga agaataagtg cgtgaatttt      780

ggatctggat ctggctacat ccctgaggcc cctagagatg gccaggctta cgtgaggaag      840

gacggcgaat gggtgctgct gagcaccttc ctgggccatc accaccacca ccattgactc      900

gag                                                                    903


<210>  48
<211>  1047
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  NTD-foldon-6*HIS

<400>  48
ggatccgccg ccaccatgtt cgtgtttctg gtgctgctgc ccctggtgtc ctcccagtgt       60

gttaatctga ccaccaggac ccagctgcct cctgcttaca ccaattcctt taccaggggc      120

gtgtactacc ccgacaaggt gttcaggtcc tccgtgctgc acagcaccca ggatctgttc      180

ctgcctttct ttagcaacgt gacctggttc cacgctatcc acgtgagcgg caccaacgga      240

accaagagat tcgacaatcc cgtgctgccc ttcaacgatg gcgtgtactt cgccagcacc      300

gagaagagca acatcatccg gggctggatc ttcggcacca ccttggattc caagacccag      360

agcctgctga tcgtgaacaa cgctaccaac gtggtcatta aggtgtgtga gttccagttt      420

tgtaacgacc cctttctggg cgtgtattat cacaagaaca ataagtcctg gatggagagc      480

gagtttaggg tgtattcctc cgctaacaac tgcacctttg agtatgtgag ccagcctttt      540

ctgatggacc tggagggcaa gcagggcaat ttcaagaacc tgagggagtt cgtgtttaag      600

aacatcgatg gctactttaa gatctactcc aagcacaccc ctatcaacct ggtgcgggat      660

ctgcctcagg gctttagcgc tctggagcct ctggtggatc tgccaatcgg catcaatatc      720

acccggtttc agaccctgct ggctctgcac aggagctacc tgacccctgg agatagctcc      780

agcggctgga cagctggagc tgctgcttac tacgtgggct acctgcagcc cagaaccttt      840

ctgctgaagt acaatgagaa cggcaccatc accgacgccg tggattgcgc tctggaccct      900

ttgtccgaga ccaagtgtac cctgggatct ggatctggct acatccctga ggcccctaga      960

gatggccagg cttacgtgag gaaggacggc gaatgggtgc tgctgagcac cttcctgggc     1020

catcaccacc accaccattg actcgag                                         1047


<210>  49
<211>  1767
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  NTD-RBD-foldon-8*HIS

<400>  49
ggatccgccg ccaccatgtt cgtgtttctg gtgctgctgc ccctggtgag ctcccagtgt       60

gttaacctga ccacccggac ccagctgcca cctgcttata ccaacagctt tacccggggc      120

gtgtactacc ctgacaaggt gttccggagc tccgtgctgc acagcacaca ggatctgttt      180

ctgcctttct ttagcaacgt gacctggttc cacgccatcc acgtgagcgg aaccaacgga      240

accaagcggt tcgacaatcc cgtgctgcct ttcaacgatg gcgtgtattt cgctagcacc      300

gagaagagca atatcatcag gggctggatc ttcggcacca ccctggattc caagacccag      360

tccctgctga tcgtgaataa tgctaccaac gtggtcatta aggtgtgtga gttccagttt      420

tgtaacgacc cctttctggg cgtgtattat cacaagaaca acaagtcctg gatggagtcc      480

gagttccggg tgtactcctc cgctaataat tgcacctttg agtatgtgtc ccagcctttt      540

ctgatggacc tggagggcaa gcagggcaac tttaagaacc tgcgggagtt cgtgtttaag      600

aacatcgatg gctatttcaa gatctactcc aagcacaccc ctatcaacct ggtgagggac      660

ctgccccagg gattttccgc tctggagcca ctggtggacc tgcctatcgg aatcaacatc      720

accaggttcc agaccctgct ggctctgcac agatcctacc tgacccctgg cgattcctcc      780

tccggatgga cagctggagc tgctgcttac tacgtgggct acctgcagcc caggaccttc      840

ttgctgaagt acaacgagaa cggcaccatc accgacgctg tggactgcgc tctggaccct      900

ttgtccgaga ccaagtgtac cctgaagagc ttcaccgtgg agaagggcat ctatcagacc      960

agcaacttcc gggtgcagcc cacagagagc atcgtgagat tccctaacat caccaacctg     1020

tgtcccttcg gcgaggtgtt taatgccacc aggtttgcta gcgtgtacgc ttggaacagg     1080

aagcggatct ccaattgcgt ggccgattat agcgtgctgt acaactccgc tagcttcagc     1140

acctttaagt gctatggcgt gagccctacc aagctgaatg atctgtgttt caccaacgtg     1200

tatgctgact ccttcgtgat ccggggcgac gaagtgaggc agatcgctcc tggacagacc     1260

ggaaagatcg ctgattataa ctacaagctg cccgacgact ttaccggctg cgtgatcgct     1320

tggaatagca ataatctgga ctccaaggtg ggcggcaatt acaattatct gtataggctg     1380

ttcaggaagt ccaacctgaa gcccttcgag agggatatct ccaccgagat ctatcaggct     1440

ggctccaccc cttgtaacgg cgttgaggga ttcaactgtt acttccccct gcagtcctac     1500

ggctttcagc ctaccaacgg cgtgggctat cagccttacc gggtggttgt gctgtccttc     1560

gagctgctgc acgctcctgc taccgtgtgt ggaccaaaga agtccaccaa cctggtgaag     1620

aacaagtgtg tgaactttgg atctggatct ggctacatcc ctgaggcccc tagagatggc     1680

caggcttacg tgaggaagga cggcgaatgg gtgctgctga gcaccttcct gggccatcac     1740

caccaccacc atcaccactg actcgag                                         1767


<210>  50
<211>  3783
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  S-foldon-8*HIS

<400>  50
ggatccgccg ccaccatgtt cgtgttcctg gtgctgctgc ccctggtgtc tagccagtgt       60

gtgaacctga ccaccaggac ccagctgcca ccagcttaca ccaattcctt cacccggggc      120

gtgtactatc ccgacaaggt gtttcggtcc agcgtgctgc actccaccca ggatctgttt      180

ctgccctttt tctccaacgt gacctggttc cacgccatcc acgtgagcgg aaccaacgga      240

accaagcggt tcgataaccc cgtgctgccc tttaatgacg gcgtgtactt tgcttccacc      300

gagaagtcca atatcatccg gggctggatc tttggcacca ccctggattc caagacccag      360

tccctgctga tcgtgaataa cgccaccaat gtggtcatta aggtgtgtga gtttcagttc      420

tgtaacgacc ctttcctggg cgtgtattat cacaagaata acaagagctg gatggagtcc      480

gagttccggg tgtactccag cgctaataac tgcacctttg agtacgtgtc ccagcccttt      540

ctgatggatc tggagggcaa gcagggcaac tttaagaacc tgcgggagtt cgtgtttaag      600

aatatcgatg gctattttaa gatctacagc aagcacaccc ctatcaatct ggtgagggac      660

ctgcctcagg gcttctctgc tctggagcct ctggtggatc tgcctatcgg catcaatatc      720

acccggtttc agaccctgct ggccctgcat agaagctatc tgacccccgg cgacagctcc      780

tctggatgga cagctggagc cgctgcttat tacgtgggct atctgcagcc caggaccttt      840

ctgctgaagt ataatgagaa cggcaccatc accgatgctg tggactgtgc cctggaccct      900

ctgtctgaga ccaagtgcac cctgaagtcc tttaccgtgg agaagggcat ctatcagacc      960

tccaacttcc gggtgcagcc cacagagagc atcgtgagat tccctaatat caccaatctg     1020

tgccctttcg gcgaggtgtt caacgctacc aggtttgcct ccgtgtatgc ctggaatcgg     1080

aagcggatct ccaactgtgt ggctgactat tccgtgctgt ataactccgc ctccttcagc     1140

accttcaagt gctatggcgt gagccctacc aagctgaacg acctgtgctt taccaacgtg     1200

tatgctgatt ccttcgtgat ccggggcgac gaggtgagac agatcgctcc tggacagacc     1260

ggcaagatcg ccgattataa ctacaagctg cctgatgatt tcaccggctg tgtgatcgct     1320

tggaacagca acaatctgga tagcaaggtg ggcggcaatt acaactatct gtaccggctg     1380

tttcggaaga gcaacctgaa gcccttcgag agggatatct ccaccgagat ctatcaggcc     1440

ggcagcaccc cttgcaatgg cgttgaaggc ttcaactgtt atttccccct gcagagctat     1500

ggctttcagc ccaccaatgg cgtgggctac cagccttacc gggtggttgt gctgagcttc     1560

gagctgctgc acgcccctgc tacagtgtgt ggaccaaaga agtccaccaa cctggtgaag     1620

aataagtgcg tgaatttcaa tttcaacggc ctgaccggca ccggcgtgtt gacagaaagc     1680

aacaagaagt tcctgccctt ccagcagttt ggccgggata tcgctgacac caccgatgct     1740

gtccgggacc ctcagacact ggagatcctg gatatcaccc cttgttcctt tggcggcgtg     1800

tccgtgatca cccctggaac aaacacctcc aatcaggtgg ccgtgctgta ccaggacgtg     1860

aactgtaccg aggtgcctgt ggccatccac gctgatcagc tgaccccaac ctggagggtg     1920

tattccaccg gctccaatgt gtttcagacc agggctggct gtctgatcgg cgctgaacac     1980

gtgaacaact cctacgagtg tgatatccct atcggcgctg gcatctgcgc ctcttaccag     2040

acacagacca atagccccag gagggccaga tccgtggctt ctcagagcat catcgcctac     2100

accatgagcc tgggcgccga aaattccgtg gcttatagca acaacagcat cgctatccct     2160

accaatttca ccatcagcgt gaccaccgag atcctgcccg tgtctatgac caagacctcc     2220

gtggactgta ccatgtatat ctgcggcgac agcaccgagt gcagcaactt gctgctgcag     2280

tatggcagct tctgcaccca gctgaatagg gctctgaccg gcatcgctgt ggagcaggat     2340

aagaacaccc aggaggtgtt cgcccaggtg aagcagatct ataagacccc tcctatcaag     2400

gactttggcg gcttcaactt cagccagatc ctgcccgacc ctagcaagcc aagcaagagg     2460

tcctttatcg aggatctgct gtttaacaag gtgaccctgg ctgacgctgg ctttatcaag     2520

cagtatggcg attgtctggg cgatatcgcc gccagagatc tgatctgcgc tcagaagttc     2580

aacggcctca ccgtgctgcc tcctctgttg acagacgaga tgatcgctca gtacacctcc     2640

gccctgctgg ctggaacaat cacctccgga tggaccttcg gcgccggagc tgctttgcag     2700

atcccattcg ccatgcagat ggcctaccgg ttcaacggca tcggcgtgac acagaatgtg     2760

ctgtatgaga accagaagct gatcgccaac cagttcaact ccgccatcgg caagatccag     2820

gatagcctga gcagcaccgc ctccgctttg ggaaagctgc aggacgtggt gaatcagaac     2880

gcccaggccc tgaacaccct ggttaagcag ctgtccagca acttcggcgc catctcctcc     2940

gtgctgaacg atatcctgtc caggctggac aaggtggagg ccgaagtgca gatcgatcgg     3000

ctgatcaccg gcaggctgca gtctttgcag acctatgtga cccagcagct gatccgggct     3060

gccgaaatca gagcctccgc taatctggcc gctaccaaga tgtccgagtg cgtgctgggc     3120

cagtccaaga gagtggattt ctgcggcaag ggctatcacc tgatgagctt cccccagtcc     3180

gctcctcacg gagttgtgtt tctgcacgtg acctacgtgc ccgcccagga aaagaacttt     3240

accaccgccc ctgctatctg ccacgacgga aaggctcact ttcccaggga gggcgtgttc     3300

gtgtccaacg gaacccactg gttcgtgacc cagcggaact tttatgagcc ccagatcatc     3360

accaccgata acacctttgt gtccggcaat tgcgacgtgg tcattggcat cgtgaataat     3420

accgtgtacg accctctgca gcccgagttg gactccttca aggaggagct ggacaagtac     3480

ttcaagaatc acaccagccc tgacgtggac ctgggcgata tttccggcat caacgccagc     3540

gtggtgaata tccagaagga gatcgacagg ctgaacgagg tggctaagaa tctgaacgag     3600

tccctgatcg acctgcagga gctgggaaag tacgagcagt acatcaagtg gcctggatct     3660

ggatctggct acatccctga ggcccctaga gatggccagg cttacgtgag gaaggacggc     3720

gaatgggtgc tgctgagcac cttcctgggc catcaccacc accaccatca ccactgactc     3780

gag                                                                   3783


<210>  51
<211>  867
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  RBD-P2-6*HIS

<400>  51
ggatccgccg ccaccatggg cgtgcccgct gtgccagagg ccagctctcc taggtggggc       60

accctgctgc tggccatctt tctggccgcc agcagaggcc tggtggccgc tagagtgcag      120

cctaccgaga gcatcgtgcg gttcccaaac atcaccaacc tgtgtccttt cggcgaggtg      180

ttcaatgcca ccaggttcgc tagcgtgtat gcctggaaca ggaagaggat ctccaattgt      240

gtggctgact actccgtgct gtacaacagc gcttccttta gcaccttcaa gtgctacggc      300

gtgtccccca ccaagctgaa cgacttgtgc tttaccaacg tgtatgccga cagctttgtg      360

atcaggggcg acgaggtgcg gcagattgct cctggacaga ccggaaagat cgctgactat      420

aattacaagc tgcccgacga cttcaccggc tgcgttatcg cttggaatag caacaatctg      480

gattccaagg tgggcggcaa ttacaattat ctgtaccggc tgttcaggaa gtccaacctg      540

aagcccttcg agagggatat cagcaccgag atctatcagg ctggctccac cccctgtaac      600

ggcgttgaag gattcaattg ctacttcccc ctgcagagct acggctttca gcctaccaat      660

ggcgtgggct atcagcccta cagggtggtt gtgctgagct ttgagctgct gcacgctcct      720

gctaccgtgt gtggaccaaa gaagtccacc aacctggtga agaataagtg cgtgaatttt      780

ggatctggaa gcggacagta catcaaggcc aattccaagt tcatcggcat caccgagctg      840

caccaccacc accatcactg actcgag                                          867


<210>  52
<211>  1014
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  NTD- P2-6*HIS

<400>  52
ggatccgccg ccaccatgtt cgtgtttctg gtgctgctgc ccctggtgtc ctcccagtgt       60

gttaatctga ccaccaggac ccagctgcct cctgcttaca ccaattcctt taccaggggc      120

gtgtactacc ccgacaaggt gttcaggtcc tccgtgctgc acagcaccca ggatctgttc      180

ctgcctttct ttagcaacgt gacctggttc cacgctatcc acgtgagcgg caccaacgga      240

accaagagat tcgacaatcc cgtgctgccc ttcaacgatg gcgtgtactt cgccagcacc      300

gagaagagca acatcatccg gggctggatc ttcggcacca ccttggattc caagacccag      360

agcctgctga tcgtgaacaa cgctaccaac gtggtcatta aggtgtgtga gttccagttt      420

tgtaacgacc cctttctggg cgtgtattat cacaagaaca ataagtcctg gatggagagc      480

gagtttaggg tgtattcctc cgctaacaac tgcacctttg agtatgtgag ccagcctttt      540

ctgatggacc tggagggcaa gcagggcaat ttcaagaacc tgagggagtt cgtgtttaag      600

aacatcgatg gctactttaa gatctactcc aagcacaccc ctatcaacct ggtgcgggat      660

ctgcctcagg gctttagcgc tctggagcct ctggtggatc tgccaatcgg catcaatatc      720

acccggtttc agaccctgct ggctctgcac aggagctacc tgacccctgg agatagctcc      780

agcggctgga cagctggagc tgctgcttac tacgtgggct acctgcagcc cagaaccttt      840

ctgctgaagt acaatgagaa cggcaccatc accgacgccg tggattgcgc tctggaccct      900

ttgtccgaga ccaagtgtac cctgggatct ggaagcggac agtacatcaa ggccaattcc      960

aagttcatcg gcatcaccga gctgaaacac caccaccacc atcactgact cgag           1014


<210>  53
<211>  1731
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  S1-P2-8*HIS

<400>  53
ggatccgccg ccaccatgtt cgtgtttctg gtgctgctgc ccctggtgag ctcccagtgt       60

gttaacctga ccacccggac ccagctgcca cctgcttata ccaacagctt tacccggggc      120

gtgtactacc ctgacaaggt gttccggagc tccgtgctgc acagcacaca ggatctgttt      180

ctgcctttct ttagcaacgt gacctggttc cacgccatcc acgtgagcgg aaccaacgga      240

accaagcggt tcgacaatcc cgtgctgcct ttcaacgatg gcgtgtattt cgctagcacc      300

gagaagagca atatcatcag gggctggatc ttcggcacca ccctggattc caagacccag      360

tccctgctga tcgtgaataa tgctaccaac gtggtcatta aggtgtgtga gttccagttt      420

tgtaacgacc cctttctggg cgtgtattat cacaagaaca acaagtcctg gatggagtcc      480

gagttccggg tgtactcctc cgctaataat tgcacctttg agtatgtgtc ccagcctttt      540

ctgatggacc tggagggcaa gcagggcaac tttaagaacc tgcgggagtt cgtgtttaag      600

aacatcgatg gctatttcaa gatctactcc aagcacaccc ctatcaacct ggtgagggac      660

ctgccccagg gattttccgc tctggagcca ctggtggacc tgcctatcgg aatcaacatc      720

accaggttcc agaccctgct ggctctgcac agatcctacc tgacccctgg cgattcctcc      780

tccggatgga cagctggagc tgctgcttac tacgtgggct acctgcagcc caggaccttc      840

ttgctgaagt acaacgagaa cggcaccatc accgacgctg tggactgcgc tctggaccct      900

ttgtccgaga ccaagtgtac cctgaagagc ttcaccgtgg agaagggcat ctatcagacc      960

agcaacttcc gggtgcagcc cacagagagc atcgtgagat tccctaacat caccaacctg     1020

tgtcccttcg gcgaggtgtt taatgccacc aggtttgcta gcgtgtacgc ttggaacagg     1080

aagcggatct ccaattgcgt ggccgattat agcgtgctgt acaactccgc tagcttcagc     1140

acctttaagt gctatggcgt gagccctacc aagctgaatg atctgtgttt caccaacgtg     1200

tatgctgact ccttcgtgat ccggggcgac gaagtgaggc agatcgctcc tggacagacc     1260

ggaaagatcg ctgattataa ctacaagctg cccgacgact ttaccggctg cgtgatcgct     1320

tggaatagca ataatctgga ctccaaggtg ggcggcaatt acaattatct gtataggctg     1380

ttcaggaagt ccaacctgaa gcccttcgag agggatatct ccaccgagat ctatcaggct     1440

ggctccaccc cttgtaacgg cgttgaggga ttcaactgtt acttccccct gcagtcctac     1500

ggctttcagc ctaccaacgg cgtgggctat cagccttacc gggtggttgt gctgtccttc     1560

gagctgctgc acgctcctgc taccgtgtgt ggaccaaaga agtccaccaa cctggtgaag     1620

aacaagtgtg tgaactttgg atctggaagc ggacagtaca tcaaggccaa ttccaagttc     1680

atcggcatca ccgagctgca ccaccaccac catcaccacc actgactcga g              1731


<210>  54
<211>  963
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  RBD-P2-foldon-6*HIS

<400>  54
ggatccgccg ccaccatggg cgtgcccgct gtgccagagg ccagctctcc taggtggggc       60

accctgctgc tggccatctt tctggccgcc agcagaggcc tggtggccgc tagagtgcag      120

cctaccgaga gcatcgtgcg gttcccaaac atcaccaacc tgtgtccttt cggcgaggtg      180

ttcaatgcca ccaggttcgc tagcgtgtat gcctggaaca ggaagaggat ctccaattgt      240

gtggctgact actccgtgct gtacaacagc gcttccttta gcaccttcaa gtgctacggc      300

gtgtccccca ccaagctgaa cgacttgtgc tttaccaacg tgtatgccga cagctttgtg      360

atcaggggcg acgaggtgcg gcagattgct cctggacaga ccggaaagat cgctgactat      420

aattacaagc tgcccgacga cttcaccggc tgcgttatcg cttggaatag caacaatctg      480

gattccaagg tgggcggcaa ttacaattat ctgtaccggc tgttcaggaa gtccaacctg      540

aagcccttcg agagggatat cagcaccgag atctatcagg ctggctccac cccctgtaac      600

ggcgttgaag gattcaattg ctacttcccc ctgcagagct acggctttca gcctaccaat      660

ggcgtgggct atcagcccta cagggtggtt gtgctgagct ttgagctgct gcacgctcct      720

gctaccgtgt gtggaccaaa gaagtccacc aacctggtga agaataagtg cgtgaatttt      780

ggatctggat ctggccagta catcaaggct aacagcaagt ttatcggcat caccgagctg      840

ggctccggct ctggatatat ccccgaggct cccagagacg gccaggctta cgttaggaag      900

gacggcgagt gggtgctgct gtctaccttc ctgggccacc accaccacca tcactgactc      960

gag                                                                    963


<210>  55
<211>  1107
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  NTD-P2-foldon-6*HIS

<400>  55
ggatccgccg ccaccatgtt cgtgtttctg gtgctgctgc ccctggtgtc ctcccagtgt       60

gttaatctga ccaccaggac ccagctgcct cctgcttaca ccaattcctt taccaggggc      120

gtgtactacc ccgacaaggt gttcaggtcc tccgtgctgc acagcaccca ggatctgttc      180

ctgcctttct ttagcaacgt gacctggttc cacgctatcc acgtgagcgg caccaacgga      240

accaagagat tcgacaatcc cgtgctgccc ttcaacgatg gcgtgtactt cgccagcacc      300

gagaagagca acatcatccg gggctggatc ttcggcacca ccttggattc caagacccag      360

agcctgctga tcgtgaacaa cgctaccaac gtggtcatta aggtgtgtga gttccagttt      420

tgtaacgacc cctttctggg cgtgtattat cacaagaaca ataagtcctg gatggagagc      480

gagtttaggg tgtattcctc cgctaacaac tgcacctttg agtatgtgag ccagcctttt      540

ctgatggacc tggagggcaa gcagggcaat ttcaagaacc tgagggagtt cgtgtttaag      600

aacatcgatg gctactttaa gatctactcc aagcacaccc ctatcaacct ggtgcgggat      660

ctgcctcagg gctttagcgc tctggagcct ctggtggatc tgccaatcgg catcaatatc      720

acccggtttc agaccctgct ggctctgcac aggagctacc tgacccctgg agatagctcc      780

agcggctgga cagctggagc tgctgcttac tacgtgggct acctgcagcc cagaaccttt      840

ctgctgaagt acaatgagaa cggcaccatc accgacgccg tggattgcgc tctggaccct      900

ttgtccgaga ccaagtgtac cctgggatct ggatctggcc agtacatcaa ggctaacagc      960

aagtttatcg gcatcaccga gctgggctcc ggctctggat atatccccga ggctcccaga     1020

gacggccagg cttacgttag gaaggacggc gagtgggtgc tgctgtctac cttcctgggc     1080

caccaccacc accatcactg actcgag                                         1107


<210>  56
<211>  1827
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  S1-P2-foldon-6*HIS

<400>  56
ggatccgccg ccaccatgtt cgtgtttctg gtgctgctgc ccctggtgag ctcccagtgt       60

gttaacctga ccacccggac ccagctgcca cctgcttata ccaacagctt tacccggggc      120

gtgtactacc ctgacaaggt gttccggagc tccgtgctgc acagcacaca ggatctgttt      180

ctgcctttct ttagcaacgt gacctggttc cacgccatcc acgtgagcgg aaccaacgga      240

accaagcggt tcgacaatcc cgtgctgcct ttcaacgatg gcgtgtattt cgctagcacc      300

gagaagagca atatcatcag gggctggatc ttcggcacca ccctggattc caagacccag      360

tccctgctga tcgtgaataa tgctaccaac gtggtcatta aggtgtgtga gttccagttt      420

tgtaacgacc cctttctggg cgtgtattat cacaagaaca acaagtcctg gatggagtcc      480

gagttccggg tgtactcctc cgctaataat tgcacctttg agtatgtgtc ccagcctttt      540

ctgatggacc tggagggcaa gcagggcaac tttaagaacc tgcgggagtt cgtgtttaag      600

aacatcgatg gctatttcaa gatctactcc aagcacaccc ctatcaacct ggtgagggac      660

ctgccccagg gattttccgc tctggagcca ctggtggacc tgcctatcgg aatcaacatc      720

accaggttcc agaccctgct ggctctgcac agatcctacc tgacccctgg cgattcctcc      780

tccggatgga cagctggagc tgctgcttac tacgtgggct acctgcagcc caggaccttc      840

ttgctgaagt acaacgagaa cggcaccatc accgacgctg tggactgcgc tctggaccct      900

ttgtccgaga ccaagtgtac cctgaagagc ttcaccgtgg agaagggcat ctatcagacc      960

agcaacttcc gggtgcagcc cacagagagc atcgtgagat tccctaacat caccaacctg     1020

tgtcccttcg gcgaggtgtt taatgccacc aggtttgcta gcgtgtacgc ttggaacagg     1080

aagcggatct ccaattgcgt ggccgattat agcgtgctgt acaactccgc tagcttcagc     1140

acctttaagt gctatggcgt gagccctacc aagctgaatg atctgtgttt caccaacgtg     1200

tatgctgact ccttcgtgat ccggggcgac gaagtgaggc agatcgctcc tggacagacc     1260

ggaaagatcg ctgattataa ctacaagctg cccgacgact ttaccggctg cgtgatcgct     1320

tggaatagca ataatctgga ctccaaggtg ggcggcaatt acaattatct gtataggctg     1380

ttcaggaagt ccaacctgaa gcccttcgag agggatatct ccaccgagat ctatcaggct     1440

ggctccaccc cttgtaacgg cgttgaggga ttcaactgtt acttccccct gcagtcctac     1500

ggctttcagc ctaccaacgg cgtgggctat cagccttacc gggtggttgt gctgtccttc     1560

gagctgctgc acgctcctgc taccgtgtgt ggaccaaaga agtccaccaa cctggtgaag     1620

aacaagtgtg tgaactttgg atctggatct ggccagtaca tcaaggctaa cagcaagttt     1680

atcggcatca ccgagctggg ctccggctct ggatatatcc ccgaggctcc cagagacggc     1740

caggcttacg ttaggaagga cggcgagtgg gtgctgctgt ctaccttcct gggccaccac     1800

caccaccatc accaccactg actcgag                                         1827


<210>  57
<211>  1371
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  RBD-ferritin  LC-6*HIS

<400>  57
ggatccgccg ccaccatggg cgtgcccgct gtgccagagg ccagctctcc taggtggggc       60

accctgctgc tggccatctt tctggccgcc agcagaggcc tggtggccgc tagagtgcag      120

cctaccgaga gcatcgtgcg gttcccaaac atcaccaacc tgtgtccttt cggcgaggtg      180

ttcaatgcca ccaggttcgc tagcgtgtat gcctggaaca ggaagaggat ctccaattgt      240

gtggctgact actccgtgct gtacaacagc gcttccttta gcaccttcaa gtgctacggc      300

gtgtccccca ccaagctgaa cgacttgtgc tttaccaacg tgtatgccga cagctttgtg      360

atcaggggcg acgaggtgcg gcagattgct cctggacaga ccggaaagat cgctgactat      420

aattacaagc tgcccgacga cttcaccggc tgcgttatcg cttggaatag caacaatctg      480

gattccaagg tgggcggcaa ttacaattat ctgtaccggc tgttcaggaa gtccaacctg      540

aagcccttcg agagggatat cagcaccgag atctatcagg ctggctccac cccctgtaac      600

ggcgttgaag gattcaattg ctacttcccc ctgcagagct acggctttca gcctaccaat      660

ggcgtgggct atcagcccta cagggtggtt gtgctgagct ttgagctgct gcacgctcct      720

gctaccgtgt gtggaccaaa gaagtccacc aacctggtga agaataagtg cgtgaatttt      780

ggatctggat ctggcgagta cggcagccac ggaaacgtgg ctaccgagtt gcaggcctat      840

gctaagctgc acctggagag gtcctatgac tacctgctgt ccgccgctta ttttaacaac      900

taccagacca acagggccgg cttttccaag ctgtttaaga agctgagcga cgaggcctgg      960

agcaagacca tcgatatcat caagcacgtg accaagcggg gcgataagat gaattttgac     1020

cagcacagca ccatgaagac cgagcggaag aactataccg ctgagaatca cgagctggag     1080

gccctggcta aggctttgga tacccagaag gagctggctg agcgggcttt ctatatccac     1140

agggaggcta cccggaatag ccagcacctg cacgaccctg agatcgctca gtacctggag     1200

gaggagttca tcgaggatca cgctgagaag atccggaccc tggccggaca taccagcgat     1260

ttgaagaagt tcatcaccgc caataatggc cacgacctga gcctggctct gtacgttttc     1320

gacgagtacc tgcagaagac cgtgcaccac caccatcacc actgactcga g              1371


<210>  58
<211>  1347
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  RBD-ferritin HC-FLAG

<400>  58
ggatccgccg ccaccatggg cgtgcccgct gtgccagagg ccagctctcc taggtggggc       60

accctgctgc tggccatctt tctggccgcc agcagaggcc tggtggccgc tagagtgcag      120

cctaccgaga gcatcgtgcg gttcccaaac atcaccaacc tgtgtccttt cggcgaggtg      180

ttcaatgcca ccaggttcgc tagcgtgtat gcctggaaca ggaagaggat ctccaattgt      240

gtggctgact actccgtgct gtacaacagc gcttccttta gcaccttcaa gtgctacggc      300

gtgtccccca ccaagctgaa cgacttgtgc tttaccaacg tgtatgccga cagctttgtg      360

atcaggggcg acgaggtgcg gcagattgct cctggacaga ccggaaagat cgctgactat      420

aattacaagc tgcccgacga cttcaccggc tgcgttatcg cttggaatag caacaatctg      480

gattccaagg tgggcggcaa ttacaattat ctgtaccggc tgttcaggaa gtccaacctg      540

aagcccttcg agagggatat cagcaccgag atctatcagg ctggctccac cccctgtaac      600

ggcgttgaag gattcaattg ctacttcccc ctgcagagct acggctttca gcctaccaat      660

ggcgtgggct atcagcccta cagggtggtt gtgctgagct ttgagctgct gcacgctcct      720

gctaccgtgt gtggaccaaa gaagtccacc aacctggtga agaataagtg cgtgaatttt      780

ggatctggat ctggcagatc ctgccggaac tccatgcggc agcagatcca gatggaggtg      840

ggcgcttccc tgcagtacct ggctatggga gcccacttta gcaaggatgt ggtgaacagg      900

cccggctttg cccagttgtt tttcgacgcc gcttccgagg agagggagca tgctatgaag      960

ctgatcgagt acctgctgat gcggggcgag ctgacaaacg acgtgagctc tctgctgcag     1020

gtgcggcctc ctacaagatc cagctggaag ggcggcgtgg aggctttgga acacgctttg     1080

agcatggaga gcgatgtgac caagagcatc aggaatgtga tcaaggcctg tgaggatgac     1140

agcgagttta atgattatca cctggtggat tacctgaccg gcgattttct ggaggagcag     1200

tacaagggcc agagggacct ggctggaaag gcttctaccc tgaagaagct gatggaccgg     1260

cacgaggctc tgggagaatt catcttcgat aagaagctgc tgggcatcga cgtggattat     1320

aaggatgatg acgataagtg actcgag                                         1347


<210>  59
<211>  1374
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  RBD194-HBsAg

<400>  59
ggatccgccg ccaccatgga gactgggctg cgctggcttc tcctggtcgc tgtgctcaaa       60

ggtgtccagt gtaacatcac caacctgtgt cctttcggcg aggtgttcaa tgccaccagg      120

ttcgctagcg tgtatgcctg gaacaggaag aggatctcca attgtgtggc tgactactcc      180

gtgctgtaca acagcgcttc ctttagcacc ttcaagtgct acggcgtgtc ccccaccaag      240

ctgaacgact tgtgctttac caacgtgtat gccgacagct ttgtgatcag gggcgacgag      300

gtgcggcaga ttgctcctgg acagaccgga aagatcgctg actataatta caagctgccc      360

gacgacttca ccggctgcgt tatcgcttgg aatagcaaca atctggattc caaggtgggc      420

ggcaattaca attatctgta ccggctgttc aggaagtcca acctgaagcc cttcgagagg      480

gatatcagca ccgagatcta tcaggctggc tccaccccct gtaacggcgt tgaaggattc      540

aattgctact tccccctgca gagctacggc tttcagccta ccaatggcgt gggctatcag      600

ccctacaggg tggttgtgct gagctttgag ctgctgcacg ctcctgctac cgtgggatct      660

ggaagcggaa tggagaacat cacctccggc ttcctgggcc cactgttggt tctgcaggcc      720

ggattcttcc tgctgaccag aatcctgacc atcccccagt ccctggacag ctggtggaca      780

tctctgaatt ttctgggcgg ctcccccgtg tgcctgggac agaactctca gagccccacc      840

agcaaccact ccccaacaag ctgcccccct atctgtcccg gatataggtg gatgtgtctg      900

aggcggttca tcatcttcct gtttatcctg ctgctgtgcc tgatcttcct gctggtgctg      960

ctggactacc agggcatgct gccagtgtgc cctctgatcc caggctctac caccaccagc     1020

accggacctt gtaagacctg caccacccct gcccagggaa atagcatgtt tccttcctgt     1080

tgctgcacca agcccaccga tggcaactgc acctgtatcc ccatccctag cagctgggcc     1140

tttgctaagt acctgtggga gtgggcttcc gtgcggttta gctggctgtc cctgctggtg     1200

cctttcgtgc agtggttcgt gggcctgagc cctacagtgt ggctgtctgc tatctggatg     1260

atgtggtatt ggggccctag cctgtacagc atcgtgtccc cattcattcc tctgctgcct     1320

atctttttct gcctgtgggt gtatatccac caccaccacc atcactgact cgag           1374


<210>  60
<211>  1491
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  NTD-ferritin HC 

<400>  60
ggatccgccg ccaccatgtt cgtgtttctg gtgctgctgc ccctggtgtc ctcccagtgt       60

gttaatctga ccaccaggac ccagctgcct cctgcttaca ccaattcctt taccaggggc      120

gtgtactacc ccgacaaggt gttcaggtcc tccgtgctgc acagcaccca ggatctgttc      180

ctgcctttct ttagcaacgt gacctggttc cacgctatcc acgtgagcgg caccaacgga      240

accaagagat tcgacaatcc cgtgctgccc ttcaacgatg gcgtgtactt cgccagcacc      300

gagaagagca acatcatccg gggctggatc ttcggcacca ccttggattc caagacccag      360

agcctgctga tcgtgaacaa cgctaccaac gtggtcatta aggtgtgtga gttccagttt      420

tgtaacgacc cctttctggg cgtgtattat cacaagaaca ataagtcctg gatggagagc      480

gagtttaggg tgtattcctc cgctaacaac tgcacctttg agtatgtgag ccagcctttt      540

ctgatggacc tggagggcaa gcagggcaat ttcaagaacc tgagggagtt cgtgtttaag      600

aacatcgatg gctactttaa gatctactcc aagcacaccc ctatcaacct ggtgcgggat      660

ctgcctcagg gctttagcgc tctggagcct ctggtggatc tgccaatcgg catcaatatc      720

acccggtttc agaccctgct ggctctgcac aggagctacc tgacccctgg agatagctcc      780

agcggctgga cagctggagc tgctgcttac tacgtgggct acctgcagcc cagaaccttt      840

ctgctgaagt acaatgagaa cggcaccatc accgacgccg tggattgcgc tctggaccct      900

ttgtccgaga ccaagtgtac cctgggatct ggatctggca gatcctgccg gaactccatg      960

cggcagcaga tccagatgga ggtgggcgct tccctgcagt acctggctat gggagcccac     1020

tttagcaagg atgtggtgaa caggcccggc tttgcccagt tgtttttcga cgccgcttcc     1080

gaggagaggg agcatgctat gaagctgatc gagtacctgc tgatgcgggg cgagctgaca     1140

aacgacgtga gctctctgct gcaggtgcgg cctcctacaa gatccagctg gaagggcggc     1200

gtggaggctt tggaacacgc tttgagcatg gagagcgatg tgaccaagag catcaggaat     1260

gtgatcaagg cctgtgagga tgacagcgag tttaatgatt atcacctggt ggattacctg     1320

accggcgatt ttctggagga gcagtacaag ggccagaggg acctggctgg aaaggcttct     1380

accctgaaga agctgatgga ccggcacgag gctctgggag aattcatctt cgataagaag     1440

ctgctgggca tcgacgtgga ttataaggat gatgacgata agtgactcga g              1491


<210>  61
<211>  1515
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  NTD-ferritin  LC 

<400>  61
ggatccgccg ccaccatgtt cgtgtttctg gtgctgctgc ccctggtgtc ctcccagtgt       60

gttaatctga ccaccaggac ccagctgcct cctgcttaca ccaattcctt taccaggggc      120

gtgtactacc ccgacaaggt gttcaggtcc tccgtgctgc acagcaccca ggatctgttc      180

ctgcctttct ttagcaacgt gacctggttc cacgctatcc acgtgagcgg caccaacgga      240

accaagagat tcgacaatcc cgtgctgccc ttcaacgatg gcgtgtactt cgccagcacc      300

gagaagagca acatcatccg gggctggatc ttcggcacca ccttggattc caagacccag      360

agcctgctga tcgtgaacaa cgctaccaac gtggtcatta aggtgtgtga gttccagttt      420

tgtaacgacc cctttctggg cgtgtattat cacaagaaca ataagtcctg gatggagagc      480

gagtttaggg tgtattcctc cgctaacaac tgcacctttg agtatgtgag ccagcctttt      540

ctgatggacc tggagggcaa gcagggcaat ttcaagaacc tgagggagtt cgtgtttaag      600

aacatcgatg gctactttaa gatctactcc aagcacaccc ctatcaacct ggtgcgggat      660

ctgcctcagg gctttagcgc tctggagcct ctggtggatc tgccaatcgg catcaatatc      720

acccggtttc agaccctgct ggctctgcac aggagctacc tgacccctgg agatagctcc      780

agcggctgga cagctggagc tgctgcttac tacgtgggct acctgcagcc cagaaccttt      840

ctgctgaagt acaatgagaa cggcaccatc accgacgccg tggattgcgc tctggaccct      900

ttgtccgaga ccaagtgtac cctgggatct ggatctggcg agtacggcag ccacggaaac      960

gtggctaccg agttgcaggc ctatgctaag ctgcacctgg agaggtccta tgactacctg     1020

ctgtccgccg cttattttaa caactaccag accaacaggg ccggcttttc caagctgttt     1080

aagaagctga gcgacgaggc ctggagcaag accatcgata tcatcaagca cgtgaccaag     1140

cggggcgata agatgaattt tgaccagcac agcaccatga agaccgagcg gaagaactat     1200

accgctgaga atcacgagct ggaggccctg gctaaggctt tggataccca gaaggagctg     1260

gctgagcggg ctttctatat ccacagggag gctacccgga atagccagca cctgcacgac     1320

cctgagatcg ctcagtacct ggaggaggag ttcatcgagg atcacgctga gaagatccgg     1380

accctggccg gacataccag cgatttgaag aagttcatca ccgccaataa tggccacgac     1440

ctgagcctgg ctctgtacgt tttcgacgag tacctgcaga agaccgtgca ccaccaccat     1500

caccactgac tcgag                                                      1515


<210>  62
<211>  1455
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  NTD-ferritin 

<400>  62
ggatccgccg ccaccatgtt cgtgtttctg gtgctgctgc ccctggtgtc ctcccagtgt       60

gttaatctga ccaccaggac ccagctgcct cctgcttaca ccaattcctt taccaggggc      120

gtgtactacc ccgacaaggt gttcaggtcc tccgtgctgc acagcaccca ggatctgttc      180

ctgcctttct ttagcaacgt gacctggttc cacgctatcc acgtgagcgg caccaacgga      240

accaagagat tcgacaatcc cgtgctgccc ttcaacgatg gcgtgtactt cgccagcacc      300

gagaagagca acatcatccg gggctggatc ttcggcacca ccttggattc caagacccag      360

agcctgctga tcgtgaacaa cgctaccaac gtggtcatta aggtgtgtga gttccagttt      420

tgtaacgacc cctttctggg cgtgtattat cacaagaaca ataagtcctg gatggagagc      480

gagtttaggg tgtattcctc cgctaacaac tgcacctttg agtatgtgag ccagcctttt      540

ctgatggacc tggagggcaa gcagggcaat ttcaagaacc tgagggagtt cgtgtttaag      600

aacatcgatg gctactttaa gatctactcc aagcacaccc ctatcaacct ggtgcgggat      660

ctgcctcagg gctttagcgc tctggagcct ctggtggatc tgccaatcgg catcaatatc      720

acccggtttc agaccctgct ggctctgcac aggagctacc tgacccctgg agatagctcc      780

agcggctgga cagctggagc tgctgcttac tacgtgggct acctgcagcc cagaaccttt      840

ctgctgaagt acaatgagaa cggcaccatc accgacgccg tggattgcgc tctggaccct      900

ttgtccgaga ccaagtgtac cctgggatct ggatctggcg atatcatcaa gctgctgaac      960

gagcaggtga ataaggagat gaactcctcc aacctgtaca tgagcatgtc cagctggtgt     1020

tacacccact ccctggacgg cgctggattg tttctgttcg accacgctgc cgaggagtac     1080

gagcacgcta agaagctgat catcttcctg aatgagaata atgtgcccgt gcagctgacc     1140

tccatctccg ctcctgagca caagtttgag ggcctgaccc agatcttcca gaaggcttac     1200

gagcacgagc agcacatcag cgagagcatc aacaacatcg tggaccacgc tatcaagtcc     1260

aaggaccacg ccacctttaa tttcctgcag tggtatgtgg ctgagcagca cgaggaggag     1320

gtgttgttta aggatatcct ggacaagatc gagctgatcg gcaatgagaa tcacggcctg     1380

tatctggctg accagtatgt gaagggcatc gccaagagca ggaagagcca ccaccaccac     1440

catcactgac tcgag                                                      1455


<210>  63
<211>  1311
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  RBD-ferritin 

<400>  63
ggatccgccg ccaccatggg cgtgcccgct gtgccagagg ccagctctcc taggtggggc       60

accctgctgc tggccatctt tctggccgcc agcagaggcc tggtggccgc tagagtgcag      120

cctaccgaga gcatcgtgcg gttcccaaac atcaccaacc tgtgtccttt cggcgaggtg      180

ttcaatgcca ccaggttcgc tagcgtgtat gcctggaaca ggaagaggat ctccaattgt      240

gtggctgact actccgtgct gtacaacagc gcttccttta gcaccttcaa gtgctacggc      300

gtgtccccca ccaagctgaa cgacttgtgc tttaccaacg tgtatgccga cagctttgtg      360

atcaggggcg acgaggtgcg gcagattgct cctggacaga ccggaaagat cgctgactat      420

aattacaagc tgcccgacga cttcaccggc tgcgttatcg cttggaatag caacaatctg      480

gattccaagg tgggcggcaa ttacaattat ctgtaccggc tgttcaggaa gtccaacctg      540

aagcccttcg agagggatat cagcaccgag atctatcagg ctggctccac cccctgtaac      600

ggcgttgaag gattcaattg ctacttcccc ctgcagagct acggctttca gcctaccaat      660

ggcgtgggct atcagcccta cagggtggtt gtgctgagct ttgagctgct gcacgctcct      720

gctaccgtgt gtggaccaaa gaagtccacc aacctggtga agaataagtg cgtgaatttt      780

ggatctggat ctggcgatat catcaagctg ctgaacgagc aggtgaataa ggagatgaac      840

tcctccaacc tgtacatgag catgtccagc tggtgttaca cccactccct ggacggcgct      900

ggattgtttc tgttcgacca cgctgccgag gagtacgagc acgctaagaa gctgatcatc      960

ttcctgaatg agaataatgt gcccgtgcag ctgacctcca tctccgctcc tgagcacaag     1020

tttgagggcc tgacccagat cttccagaag gcttacgagc acgagcagca catcagcgag     1080

agcatcaaca acatcgtgga ccacgctatc aagtccaagg accacgccac ctttaatttc     1140

ctgcagtggt atgtggctga gcagcacgag gaggaggtgt tgtttaagga tatcctggac     1200

aagatcgagc tgatcggcaa tgagaatcac ggcctgtatc tggctgacca gtatgtgaag     1260

ggcatcgcca agagcaggaa gagccaccac caccaccatc actgactcga g              1311


<210>  64
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  P2_1

<400>  64

Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu 
1               5                   10                  15  


<210>  65
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  P2_2

<400>  65

Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Lys 
1               5                   10                  15      


<210>  66
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  P2_3

<400>  66

Met Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu 
1               5                   10                  15      


<210>  67
<211>  27
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  foldon_1

<400>  67

Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu 
1               5                   10                  15      


Trp Val Leu Leu Ser Thr Phe Leu Ser Pro Ala 
            20                  25          


<210>  68
<211>  27
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  foldon_2

<400>  68

Ala Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg 
1               5                   10                  15      


Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe 
            20                  25          


<210>  69
<211>  27
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  foldon_3

<400>  69

Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp 
1               5                   10                  15      


Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly 
            20                  25          


<210>  70
<211>  173
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  ferritin HC

<400>  70

Arg Ser Cys Arg Asn Ser Met Arg Gln Gln Ile Gln Met Glu Val Gly 
1               5                   10                  15      


Ala Ser Leu Gln Tyr Leu Ala Met Gly Ala His Phe Ser Lys Asp Val 
            20                  25                  30          


Val Asn Arg Pro Gly Phe Ala Gln Leu Phe Phe Asp Ala Ala Ser Glu 
        35                  40                  45              


Glu Arg Glu His Ala Met Lys Leu Ile Glu Tyr Leu Leu Met Arg Gly 
    50                  55                  60                  


Glu Leu Thr Asn Asp Val Ser Ser Leu Leu Gln Val Arg Pro Pro Thr 
65                  70                  75                  80  


Arg Ser Ser Trp Lys Gly Gly Val Glu Ala Leu Glu His Ala Leu Ser 
                85                  90                  95      


Met Glu Ser Asp Val Thr Lys Ser Ile Arg Asn Val Ile Lys Ala Cys 
            100                 105                 110         


Glu Asp Asp Ser Glu Phe Asn Asp Tyr His Leu Val Asp Tyr Leu Thr 
        115                 120                 125             


Gly Asp Phe Leu Glu Glu Gln Tyr Lys Gly Gln Arg Asp Leu Ala Gly 
    130                 135                 140                 


Lys Ala Ser Thr Leu Lys Lys Leu Met Asp Arg His Glu Ala Leu Gly 
145                 150                 155                 160 


Glu Phe Ile Phe Asp Lys Lys Leu Leu Gly Ile Asp Val 
                165                 170             


<210>  71
<211>  183
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  ferritin LC

<400>  71

Glu Tyr Gly Ser His Gly Asn Val Ala Thr Glu Leu Gln Ala Tyr Ala 
1               5                   10                  15      


Lys Leu His Leu Glu Arg Ser Tyr Asp Tyr Leu Leu Ser Ala Ala Tyr 
            20                  25                  30          


Phe Asn Asn Tyr Gln Thr Asn Arg Ala Gly Phe Ser Lys Leu Phe Lys 
        35                  40                  45              


Lys Leu Ser Asp Glu Ala Trp Ser Lys Thr Ile Asp Ile Ile Lys His 
    50                  55                  60                  


Val Thr Lys Arg Gly Asp Lys Met Asn Phe Asp Gln His Ser Thr Met 
65                  70                  75                  80  


Lys Thr Glu Arg Lys Asn Tyr Thr Ala Glu Asn His Glu Leu Glu Ala 
                85                  90                  95      


Leu Ala Lys Ala Leu Asp Thr Gln Lys Glu Leu Ala Glu Arg Ala Phe 
            100                 105                 110         


Tyr Ile His Arg Glu Ala Thr Arg Asn Ser Gln His Leu His Asp Pro 
        115                 120                 125             


Glu Ile Ala Gln Tyr Leu Glu Glu Glu Phe Ile Glu Asp His Ala Glu 
    130                 135                 140                 


Lys Ile Arg Thr Leu Ala Gly His Thr Ser Asp Leu Lys Lys Phe Ile 
145                 150                 155                 160 


Thr Ala Asn Asn Gly His Asp Leu Ser Leu Ala Leu Tyr Val Phe Asp 
                165                 170                 175     


Glu Tyr Leu Gln Lys Thr Val 
            180             


<210>  72
<211>  167
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  ˾

<400>  72

Met Leu Ser Lys Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys 
1               5                   10                  15      


Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr 
            20                  25                  30          


Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala 
        35                  40                  45              


Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn 
    50                  55                  60                  


Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe 
65                  70                  75                  80  


Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His 
                85                  90                  95      


Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys 
            100                 105                 110         


Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His 
        115                 120                 125             


Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile 
    130                 135                 140                 


Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly 
145                 150                 155                 160 


Ile Ala Lys Ser Arg Lys Ser 
                165         


<210>  73
<211>  226
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ҹα濹ԭHBsAg

<400>  73

Met Glu Asn Ile Thr Ser Gly Phe Leu Gly Pro Leu Leu Val Leu Gln 
1               5                   10                  15      


Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu 
            20                  25                  30          


Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Ser Pro Val Cys 
        35                  40                  45              


Leu Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn His Ser Pro Thr Ser 
    50                  55                  60                  


Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe 
65                  70                  75                  80  


Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val 
                85                  90                  95      


Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly 
            100                 105                 110         


Ser Thr Thr Thr Ser Thr Gly Pro Cys Lys Thr Cys Thr Thr Pro Ala 
        115                 120                 125             


Gln Gly Asn Ser Met Phe Pro Ser Cys Cys Cys Thr Lys Pro Thr Asp 
    130                 135                 140                 


Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala Lys 
145                 150                 155                 160 


Tyr Leu Trp Glu Trp Ala Ser Val Arg Phe Ser Trp Leu Ser Leu Leu 
                165                 170                 175     


Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu 
            180                 185                 190         


Ser Ala Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Ser Ile 
        195                 200                 205             


Val Ser Pro Phe Ile Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val 
    210                 215                 220                 


Tyr Ile 
225     


<210>  74
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  ź_1

<400>  74

Met Gly Val Pro Ala Val Pro Glu Ala Ser Ser Pro Arg Trp Gly Thr 
1               5                   10                  15      


Leu Leu Leu Ala Ile Phe Leu Ala Ala Ser Arg Gly Leu Val Ala Ala 
            20                  25                  30          


<210>  75
<211>  12
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  ź_2

<400>  75

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser 
1               5                   10          


<210>  76
<211>  223
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  RBD Betaͻ

<400>  76

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
    210                 215                 220             


<210>  77
<211>  288
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  NTD Betaͻ

<400>  77

Gln Cys Val Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Ala Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu His Ile Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
225                 230                 235                 240 


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
                245                 250                 255     


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
            260                 265                 270         


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
        275                 280                 285             


<210>  78
<211>  26
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  foldonɾT4άC

<400>  78

Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp 
1               5                   10                  15      


Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
            20                  25          


<210>  79
<211>  557
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  RBD-NTD-foldonںϣBetaͻ꣩

<400>  79

Gln Cys Val Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Ala Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu His Ile Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
225                 230                 235                 240 


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
                245                 250                 255     


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
            260                 265                 270         


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
        275                 280                 285             


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
    290                 295                 300                 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
305                 310                 315                 320 


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
                325                 330                 335     


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
            340                 345                 350         


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
        355                 360                 365             


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
    370                 375                 380                 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
385                 390                 395                 400 


Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
                405                 410                 415     


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
            420                 425                 430         


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
        435                 440                 445             


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
    450                 455                 460                 


Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
465                 470                 475                 480 


Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
                485                 490                 495     


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
            500                 505                 510         


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Gly Ser Gly 
        515                 520                 525             


Ser Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg 
    530                 535                 540                 


Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly 
545                 550                 555         


<210>  80
<211>  255
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  RBD-foldon Betaͻ

<400>  80

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Gly 
    210                 215                 220                 


Ser Gly Ser Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr 
225                 230                 235                 240 


Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly 
                245                 250                 255 


<210>  81
<211>  320
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  NTD-foldon Betaͻ

<400>  81

Gln Cys Val Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Ala Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu His Ile Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
225                 230                 235                 240 


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
                245                 250                 255     


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
            260                 265                 270         


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
        275                 280                 285             


Gly Ser Gly Ser Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala 
    290                 295                 300                 


Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly 
305                 310                 315                 320 


<210>  82
<211>  1270
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Beta501Y.V2ǵ

<400>  82

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Ala 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu His Ile Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr 
                245                 250                 255     


Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 
            260                 265                 270         


Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 
        275                 280                 285             


Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 
    290                 295                 300                 


Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 
305                 310                 315                 320 


Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
                325                 330                 335     


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
            340                 345                 350         


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 
        355                 360                 365             


Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
    370                 375                 380                 


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
385                 390                 395                 400 


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala 
                405                 410                 415     


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
            420                 425                 430         


Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr 
        435                 440                 445             


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
    450                 455                 460                 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val 
465                 470                 475                 480 


Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro 
                485                 490                 495     


Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 
        515                 520                 525             


Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro 
                565                 570                 575     


Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe 
625                 630                 635                 640 


Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln 
            660                 665                 670         


Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser Gln Ser 
        675                 680                 685             


Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu Asn Ser Val Ala Tyr 
    690                 695                 700                 


Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr 
705                 710                 715                 720 


Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 
                725                 730                 735     


Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 
            740                 745                 750         


Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala 
        755                 760                 765             


Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 
    770                 775                 780                 


Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser 
785                 790                 795                 800 


Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu 
                805                 810                 815     


Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
            820                 825                 830         


Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
        835                 840                 845             


Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
    850                 855                 860                 


Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
865                 870                 875                 880 


Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 
                885                 890                 895     


Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
            900                 905                 910         


Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
        915                 920                 925             


Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 
    930                 935                 940                 


Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val 
945                 950                 955                 960 


Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
                965                 970                 975     


Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg 
            980                 985                 990         


Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln Gln 
        995                 1000                1005            


Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn Leu Ala Ala Thr 
    1010                1015                1020                


Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys Arg Val Asp Phe Cys 
1025                1030                1035                1040


Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln Ser Ala Pro His Gly 
                1045                1050                1055    


Val Val Phe Leu His Val Thr Tyr Val Pro Ala Gln Glu Lys Asn Phe 
            1060                1065                1070        


Thr Thr Ala Pro Ala Ile Cys His Asp Gly Lys Ala His Phe Pro Arg 
        1075                1080                1085            


Glu Gly Val Phe Val Ser Asn Gly Thr His Trp Phe Val Thr Gln Arg 
    1090                1095                1100                


Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr Asp Asn Thr Phe Val Ser 
1105                1110                1115                1120


Gly Asn Cys Asp Val Val Ile Gly Ile Val Asn Asn Thr Val Tyr Asp 
                1125                1130                1135    


Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys Glu Glu Leu Asp Lys Tyr 
            1140                1145                1150        


Phe Lys Asn His Thr Ser Pro Asp Val Asp Leu Gly Asp Ile Ser Gly 
        1155                1160                1165            


Ile Asn Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp Arg Leu Asn 
    1170                1175                1180                


Glu Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu Gln Glu Leu 
1185                1190                1195                1200


Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile Trp Leu Gly 
                1205                1210                1215    


Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile Met Leu Cys 
            1220                1225                1230        


Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys Ser Cys Gly 
        1235                1240                1245            


Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro Val Leu Lys Gly 
    1250                1255                1260                


Val Lys Leu His Tyr Thr 
1265                1270


<210>  83
<211>  223
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  RBD Gammaͻ

<400>  83

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Thr Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
    210                 215                 220             


<210>  84
<211>  291
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  NTD Gammaͻ

<400>  84

Gln Cys Val Asn Phe Thr Asn Arg Thr Gln Leu Pro Ser Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Tyr Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Ser Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys 
    290     


<210>  85
<211>  560
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  RBD-NTD-foldonںϣGammaͻ꣩

<400>  85

Gln Cys Val Asn Phe Thr Asn Arg Thr Gln Leu Pro Ser Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Tyr Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Ser Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
                325                 330                 335     


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Thr Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
            420                 425                 430         


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
        435                 440                 445             


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
    450                 455                 460                 


Thr Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
465                 470                 475                 480 


Ser Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg 
                485                 490                 495     


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
            500                 505                 510         


Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
        515                 520                 525             


Gly Ser Gly Ser Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala 
    530                 535                 540                 


Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly 
545                 550                 555                 560 


<210>  86
<211>  255
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  RBD-foldon Gammaͻ

<400>  86

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Thr Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Gly 
    210                 215                 220                 


Ser Gly Ser Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr 
225                 230                 235                 240 


Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly 
                245                 250                 255 


<210>  87
<211>  323
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  NTD-foldon Gammaͻ

<400>  87

Gln Cys Val Asn Phe Thr Asn Arg Thr Gln Leu Pro Ser Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Tyr Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Ser Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Gly Ser Gly Ser Gly Tyr Ile Pro Glu Ala Pro Arg Asp 
    290                 295                 300                 


Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr 
305                 310                 315                 320 


Phe Leu Gly 
            


<210>  88
<211>  1273
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Gamma501Y.V3ǵ

<400>  88

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Phe Thr Asn Arg Thr Gln Leu Pro Ser Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Tyr Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Ser Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Thr Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu Tyr Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val 
        995                 1000                1005            


Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn Leu 
    1010                1015                1020                


Ala Ala Ile Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys Arg Val 
1025                1030                1035                1040


Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln Ser Ala 
                1045                1050                1055    


Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro Ala Gln Glu 
            1060                1065                1070        


Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly Lys Ala His 
        1075                1080                1085            


Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His Trp Phe Val 
    1090                1095                1100                


Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr Asp Asn Thr 
1105                1110                1115                1120


Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val Asn Asn Thr 
                1125                1130                1135    


Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys Glu Glu Leu 
            1140                1145                1150        


Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp Leu Gly Asp 
        1155                1160                1165            


Ile Ser Gly Ile Asn Ala Ser Phe Val Asn Ile Gln Lys Glu Ile Asp 
    1170                1175                1180                


Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu 
1185                1190                1195                1200


Gln Glu Leu Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile 
                1205                1210                1215    


Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile 
            1220                1225                1230        


Met Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys 
        1235                1240                1245            


Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro Val 
    1250                1255                1260                


Leu Lys Gly Val Lys Leu His Tyr Thr 
1265                1270            


<210>  89
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Խͷ

<400>  89

Gly Ser Gly Ser Gly 
1               5   


<210>  90
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  

<400>  90

Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
1               5                   10                  


<210>  91
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  ź_3

<400>  91

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  92
<211>  566
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  AͣH1N1

<400>  92

Met Lys Ala Ile Leu Val Val Met Leu Tyr Thr Phe Thr Thr Ala Asn 
1               5                   10                  15      


Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Lys Leu Arg Gly Val 
    50                  55                  60                  


Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Ser Leu Ser Thr Ala Arg Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Ser Asn Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
            100                 105                 110         


Ile Asn Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His Asp 
    130                 135                 140                 


Ser Asp Asn Gly Val Thr Ala Ala Cys Pro His Ala Gly Ala Lys Ser 
145                 150                 155                 160 


Phe Tyr Lys Asn Leu Ile Trp Leu Val Lys Lys Gly Lys Ser Tyr Pro 
                165                 170                 175     


Lys Ile Asn Gln Thr Tyr Ile Asn Asp Lys Gly Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Ile His His Pro Pro Thr Ile Ala Asp Gln Gln Ser Leu 
        195                 200                 205             


Tyr Gln Asn Ala Asp Ala Tyr Val Phe Val Gly Thr Ser Arg Tyr Ser 
    210                 215                 220                 


Lys Lys Phe Lys Pro Glu Ile Ala Thr Arg Pro Lys Val Arg Asp Gln 
225                 230                 235                 240 


Glu Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro Gly Asp Lys 
                245                 250                 255     


Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Ala Pro Arg Tyr Ala Phe 
            260                 265                 270         


Thr Met Glu Arg Asp Ala Gly Ser Gly Ile Ile Ile Ser Asp Thr Pro 
        275                 280                 285             


Val His Asp Cys Asn Thr Thr Cys Gln Thr Pro Glu Gly Ala Ile Asn 
    290                 295                 300                 


Thr Ser Leu Pro Phe Gln Asn Val His Pro Ile Thr Ile Gly Lys Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Leu Ala Thr Gly Leu Arg 
                325                 330                 335     


Asn Val Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asp Lys Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn His 
                405                 410                 415     


Leu Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Arg Asn Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Thr Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu 
            500                 505                 510         


Asn Arg Glu Lys Ile Asp Gly Val Lys Leu Asp Ser Thr Arg Ile Tyr 
        515                 520                 525             


Gln Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Val 
    530                 535                 540                 


Val Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu 
545                 550                 555                 560 


Gln Cys Arg Ile Cys Ile 
                565     


<210>  93
<211>  566
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  AͣH3N2

<400>  93

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Ile Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Arg Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Asn Ser Ser Ile 
    50                  55                  60                  


Gly Glu Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Gly Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Glu Trp Asp Leu Phe Val Glu Arg Ser Arg Ala Asn Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Lys Asn Glu Ser Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Lys Gln Asn Gly Thr Ser Ser Ala Cys Ile Arg Gly Ser Ser 
145                 150                 155                 160 


Ser Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Asn Tyr Thr 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Gln Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Ser Thr Asp Lys Asp Gln Ile 
        195                 200                 205             


Ser Leu Phe Ala Gln Pro Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Ala Val Ile Pro Asn Ile Gly Ser Arg Pro Arg Ile Arg 
225                 230                 235                 240 


Asp Ile Pro Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Lys Cys Lys Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Ser Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Arg Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Val Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Lys Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Glu Thr Tyr Asp His Asn Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Met Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Ile Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210>  94
<211>  582
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  BͣB/Washington/02/2019

<400>  94

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn His 
    530                 535                 540                 


Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala Val Thr 
545                 550                 555                 560 


Leu Met Ile Ala Ile Phe Val Val Tyr Met Val Ser Arg Asp Asn Val 
                565                 570                 575     


Ser Cys Ser Ile Cys Leu 
            580         


<210>  95
<211>  584
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  BͣB/PHUKET/3073/2013

<400>  95

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser Tyr Phe Ala Asn Leu Lys Gly Thr Arg Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Asp Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Met Cys Val Gly Thr Thr Pro Ser Ala Lys Ala 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu Lys Ile Arg Leu Ser Thr Gln Asn Val Ile Asp Ala Glu Lys 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ala Thr Ser Lys Ile Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asp Asn Tyr Lys Asn Ala Thr Asn Pro Leu Thr Val Glu Val Pro 
            180                 185                 190         


Tyr Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His 
        195                 200                 205             


Ser Asp Asn Lys Thr Gln Met Lys Ser Leu Tyr Gly Asp Ser Asn Pro 
    210                 215                 220                 


Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser 
225                 230                 235                 240 


Gln Ile Gly Asp Phe Pro Asp Gln Thr Glu Asp Gly Gly Leu Pro Gln 
                245                 250                 255     


Ser Gly Arg Ile Val Val Asp Tyr Met Met Gln Lys Pro Gly Lys Thr 
            260                 265                 270         


Gly Thr Ile Val Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val Trp 
        275                 280                 285             


Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile 
    290                 295                 300                 


Gly Glu Ala Asp Cys Leu His Glu Glu Tyr Gly Gly Leu Asn Lys Ser 
305                 310                 315                 320 


Lys Pro Tyr Tyr Thr Gly Lys His Ala Lys Ala Ile Gly Asn Cys Pro 
                325                 330                 335     


Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg 
            340                 345                 350         


Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala 
        355                 360                 365             


Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly 
    370                 375                 380                 


Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys 
385                 390                 395                 400 


Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu 
                405                 410                 415     


Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp 
            420                 425                 430         


Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu 
        435                 440                 445             


Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser 
    450                 455                 460                 


Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu 
465                 470                 475                 480 


Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly Asn 
                485                 490                 495     


Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg 
            500                 505                 510         


Ile Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe 
        515                 520                 525             


Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp 
    530                 535                 540                 


Asn His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala 
545                 550                 555                 560 


Val Thr Leu Met Leu Ala Ile Phe Ile Val Tyr Met Val Ser Arg Asp 
                565                 570                 575     


Asn Val Ser Cys Ser Ile Cys Leu 
            580                 


<210>  96
<211>  579
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  RBD-NTD-foldonںϣwuhan

<400>  96

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro 
            20                  25                  30          


Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val 
        35                  40                  45              


Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe 
    50                  55                  60                  


Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn 
65                  70                  75                  80  


Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val 
                85                  90                  95      


Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe 
            100                 105                 110         


Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn 
        115                 120                 125             


Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp 
    130                 135                 140                 


Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu 
145                 150                 155                 160 


Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr 
                165                 170                 175     


Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe 
            180                 185                 190         


Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys 
        195                 200                 205             


Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln 
    210                 215                 220                 


Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn 
225                 230                 235                 240 


Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr 
                245                 250                 255     


Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr 
            260                 265                 270         


Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn 
        275                 280                 285             


Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu 
    290                 295                 300                 


Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln 
305                 310                 315                 320 


Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro 
                325                 330                 335     


Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
            340                 345                 350         


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
        355                 360                 365             


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
    370                 375                 380                 


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
385                 390                 395                 400 


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
                405                 410                 415     


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
            420                 425                 430         


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
        435                 440                 445             


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
    450                 455                 460                 


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
465                 470                 475                 480 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
                485                 490                 495     


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
            500                 505                 510         


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
        515                 520                 525             


Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys 
    530                 535                 540                 


Val Asn Phe Gly Ser Gly Ser Gly Tyr Ile Pro Glu Ala Pro Arg Asp 
545                 550                 555                 560 


Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr 
                565                 570                 575     


Phe Leu Gly 
            

<210>  97
<211>  219
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  RBDWH8Cys

<400>  97

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys 
    210                 215                 


<210>  98
<211>  248
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  RBDWH10CysN˼2

<400>  98

Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser 
1               5                   10                  15      


Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln 
            20                  25                  30          


Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro 
        35                  40                  45              


Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp 
    50                  55                  60                  


Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr 
65                  70                  75                  80  


Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr 
                85                  90                  95      


Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val 
            100                 105                 110         


Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys 
        115                 120                 125             


Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val 
    130                 135                 140                 


Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr 
145                 150                 155                 160 


Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu 
                165                 170                 175     


Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn 
            180                 185                 190         


Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe 
        195                 200                 205             


Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu 
    210                 215                 220                 


Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys 
225                 230                 235                 240 


Ser Thr Asn Leu Val Lys Asn Lys 
                245             


<210>  99
<211>  274
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  RBDWH10CysC˼2

<400>  99

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
    210                 215                 220                 


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
225                 230                 235                 240 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
                245                 250                 255     


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
            260                 265                 270         


Ser Phe 
        


<210>  100
<211>  303
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  RBDWH12CysN˺C˼2

<400>  100
Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser 
1               5                   10                  15      


Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln 
            20                  25                  30          


Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro 
        35                  40                  45              


Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp 
    50                  55                  60                  


Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr 
65                  70                  75                  80  


Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr 
                85                  90                  95      


Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val 
            100                 105                 110         


Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys 
        115                 120                 125             


Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val 
    130                 135                 140                 


Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr 
145                 150                 155                 160 


Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu 
                165                 170                 175     


Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn 
            180                 185                 190         


Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe 
        195                 200                 205             


Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu 
    210                 215                 220                 


Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys 
225                 230                 235                 240 


Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly 
                245                 250                 255     


Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro 
            260                 265                 270         


Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg 
        275                 280                 285             


Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
    290                 295                 300             


<210>  101
<211>  219
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  RBDAfrica8Cys

<400>  101

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys 
    210                 215                 


<210>  102
<211>  248
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  RBDAfrica10CysN˼2

<400>  102

Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser 
1               5                   10                  15      


Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln 
            20                  25                  30          


Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro 
        35                  40                  45              


Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp 
    50                  55                  60                  


Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr 
65                  70                  75                  80  


Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr 
                85                  90                  95      


Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val 
            100                 105                 110         


Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn 
        115                 120                 125             


Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val 
    130                 135                 140                 


Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr 
145                 150                 155                 160 


Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu 
                165                 170                 175     


Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn 
            180                 185                 190         


Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe 
        195                 200                 205             


Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu 
    210                 215                 220                 


Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys 
225                 230                 235                 240 


Ser Thr Asn Leu Val Lys Asn Lys 
                245             


<210>  103
<211>  274
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  RBDAfrica10CysC˼2

<400>  103

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
    210                 215                 220                 


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
225                 230                 235                 240 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
                245                 250                 255     


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
            260                 265                 270         


Ser Phe 
        


<210>  104
<211>  303
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  RBDAfrica12CysN˺C˼2

<400>  104

Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser 
1               5                   10                  15      


Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln 
            20                  25                  30          


Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro 
        35                  40                  45              


Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp 
    50                  55                  60                  


Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr 
65                  70                  75                  80  


Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr 
                85                  90                  95      


Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val 
            100                 105                 110         


Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn 
        115                 120                 125             


Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val 
    130                 135                 140                 


Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr 
145                 150                 155                 160 


Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu 
                165                 170                 175     


Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn 
            180                 185                 190         


Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe 
        195                 200                 205             


Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu 
    210                 215                 220                 


Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys 
225                 230                 235                 240 


Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly 
                245                 250                 255     


Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro 
            260                 265                 270         


Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg 
        275                 280                 285             


Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
    290                 295                 300             


<210>  105
<211>  219
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  RBDDelta8Cys

<400>  105

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Arg Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Lys 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys 
    210                 215                 


<210>  106
<211>  248
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  RBDDelta10CysN˼2

<400>  106

Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser 
1               5                   10                  15      


Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln 
            20                  25                  30          


Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro 
        35                  40                  45              


Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp 
    50                  55                  60                  


Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr 
65                  70                  75                  80  


Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr 
                85                  90                  95      


Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val 
            100                 105                 110         


Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys 
        115                 120                 125             


Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val 
    130                 135                 140                 


Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr 
145                 150                 155                 160 


Asn Tyr Arg Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu 
                165                 170                 175     


Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Lys Pro Cys Asn 
            180                 185                 190         


Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe 
        195                 200                 205             


Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu 
    210                 215                 220                 


Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys 
225                 230                 235                 240 


Ser Thr Asn Leu Val Lys Asn Lys 
                245             


<210>  107
<211>  274
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  RBDDelta10CysC˼2

<400>  107

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Arg Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Lys 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
    210                 215                 220                 


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
225                 230                 235                 240 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
                245                 250                 255     


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
            260                 265                 270         


Ser Phe 
        


<210>  108
<211>  303
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  RBDDelta12CysN˺C˼2

<400>  108

Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser 
1               5                   10                  15      


Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln 
            20                  25                  30          


Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro 
        35                  40                  45              


Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp 
    50                  55                  60                  


Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr 
65                  70                  75                  80  


Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr 
                85                  90                  95      


Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val 
            100                 105                 110         


Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys 
        115                 120                 125             


Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val 
    130                 135                 140                 


Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr 
145                 150                 155                 160 


Asn Tyr Arg Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu 
                165                 170                 175     


Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Lys Pro Cys Asn 
            180                 185                 190         


Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe 
        195                 200                 205             


Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu 
    210                 215                 220                 


Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys 
225                 230                 235                 240 


Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly 
                245                 250                 255     


Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro 
            260                 265                 270         


Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg 
        275                 280                 285             


Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
    290                 295                 300             


<210>  109
<211>  305
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  NTDWH

<400>  109

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe 
305 


<210>  110
<211>  302
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  NTDAfrica

<400>  110

Gln Cys Val Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Ala Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu His Ile Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
225                 230                 235                 240 


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
                245                 250                 255     


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
            260                 265                 270         


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
        275                 280                 285             


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
    290                 295                 300         


<210>  111
<211>  303
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  NTDDelta

<400>  111

Gln Cys Val Asn Leu Arg Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Ile Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Asp Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Gly Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
    290                 295                 300             

