                         SEQUENCE LISTING

<110>  Nanjing Legend Biotech Co., Ltd.
 
<120>  USE OF A CHIMERIC CO-STIMULATORY RECEPTOR FOR CELL THERAPY

<130>  L2-W20235WO_SEQ_LISTING

<140>
<141>

<150>  PCT/CN2020/122594
<151>  2020-10-21

<160>  59    

<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  1

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  2
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8alpha signal peptide

<400>  2

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  3
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8alpha hinge

<400>  3

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  4
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 hinge

<400>  4

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro 
        35                  


<210>  5
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8alpha transmembrane domain

<400>  5

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  6
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 transmembrane domain

<400>  6

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  7
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2 transmembrane domain

<400>  7

Ile Tyr Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met Val 
1               5                   10                  15      


Phe Val Ala Leu Leu Val Phe Tyr Ile Thr 
            20                  25      


<210>  8
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOS transmembrane domain

<400>  8

Phe Trp Leu Pro Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu 
1               5                   10                  15      


Gly Cys Ile Leu Ile 
            20      


<210>  9
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB intracellular domain

<400>  9

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  10
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 intracellular domain

<400>  10

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  11
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2 intracellular domain

<400>  11

Lys Arg Lys Lys Gln Arg Ser Arg Arg Asn Asp Glu Glu Leu Glu Thr 
1               5                   10                  15      


Arg Ala His Arg Val Ala Thr Glu Glu Arg Gly Arg Lys Pro His Gln 
            20                  25                  30          


Ile Pro Ala Ser Thr Pro Gln Asn Pro Ala Thr Ser Gln His Pro Pro 
        35                  40                  45              


Pro Pro Pro Gly His Arg Ser Gln Ala Pro Ser His Arg Pro Pro Pro 
    50                  55                  60                  


Pro Gly His Arg Val Gln His Gln Pro Gln Lys Arg Pro Pro Ala Pro 
65                  70                  75                  80  


Ser Gly Thr Gln Val His Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro 
                85                  90                  95      


Arg Val Gln Pro Lys Pro Pro His Gly Ala Ala Glu Asn Ser Leu Ser 
            100                 105                 110         


Pro Ser Ser Asn 
        115     


<210>  12
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOS intracellular domain

<400>  12

Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn 
1               5                   10                  15      


Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg 
            20                  25                  30          


Leu Thr Asp Val Thr Leu 
        35              


<210>  13
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3zeta intracellular domain

<400>  13

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  14
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A element

<400>  14

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  15
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14.18 variable light chain

<400>  15

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Gln Ser Leu Val His Arg 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile His Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  16
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14.18 variable heavy chain

<400>  16

Glu Val Gln Leu Leu Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Met Ile Ser Cys Lys Ala Ser Gly Ser Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Asn Ile Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Asp Pro Tyr Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Ser Gly Met Glu Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  17
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Oportuzumab variable light chain

<400>  17

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Thr Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Ile Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys 
            100                 105                 110         


Arg 
    


<210>  18
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Oportuzumab variable heavy chain

<400>  18

Glu Val Gln Leu Val Gln Ser Gly Pro Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ala Asp Ser Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Phe Ser Leu Asp Thr Ser Ala Ser Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Ala Ile Lys Gly Asp Tyr Trp Gly Gln Gly Thr Leu Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  19
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-DLL3 VHH-VHH

<400>  19

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Phe Ser Gly Tyr Gly Val Ser 
            20                  25                  30          


Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Thr Val Gly Ser Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Val Gly Tyr Leu Ser Gly Gly Ser Trp Asp Val Pro Gly Arg Tyr 
            100                 105                 110         


Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
    130                 135                 140                 


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
145                 150                 155                 160 


Ser Cys Ala Ala Ser Gly Asn Thr Tyr Ser Ser Asn Tyr Met Gly Trp 
                165                 170                 175     


Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Glu Val Ala Val Ile Tyr 
            180                 185                 190         


Thr Arg Gly Gly His Thr Tyr Tyr Val Asp Ser Val Arg Gly Arg Phe 
        195                 200                 205             


Thr Ile Ser Gln Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn 
    210                 215                 220                 


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ser Ser 
225                 230                 235                 240 


Arg His Arg Leu Gly Leu Asn Asn Pro Arg Asp Tyr Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265 


<210>  20
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GD2-BBz

<400>  20

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Gln 
        35                  40                  45              


Ser Leu Val His Arg Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile His Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
            100                 105                 110         


Phe Cys Ser Gln Ser Thr His Val Pro Pro Leu Thr Phe Gly Ala Gly 
        115                 120                 125             


Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Gln Ser Gly Pro Glu Leu 
145                 150                 155                 160 


Glu Lys Pro Gly Ala Ser Val Met Ile Ser Cys Lys Ala Ser Gly Ser 
                165                 170                 175     


Ser Phe Thr Gly Tyr Asn Met Asn Trp Val Arg Gln Asn Ile Gly Lys 
            180                 185                 190         


Ser Leu Glu Trp Ile Gly Ala Ile Asp Pro Tyr Tyr Gly Gly Thr Ser 
        195                 200                 205             


Tyr Asn Gln Lys Phe Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser 
    210                 215                 220                 


Ser Ser Thr Ala Tyr Met His Leu Lys Ser Leu Thr Ser Glu Asp Ser 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Val Ser Gly Met Glu Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
            260                 265                 270         


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
        275                 280                 285             


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
    290                 295                 300                 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
305                 310                 315                 320 


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys 
                325                 330                 335     


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
            340                 345                 350         


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
        355                 360                 365             


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            420                 425                 430         


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        435                 440                 445             


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    450                 455                 460                 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
465                 470                 475                 480 


Ala Leu Pro Pro Arg 
                485 


<210>  21
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GD2-28

<400>  21

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Gln 
        35                  40                  45              


Ser Leu Val His Arg Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile His Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
            100                 105                 110         


Phe Cys Ser Gln Ser Thr His Val Pro Pro Leu Thr Phe Gly Ala Gly 
        115                 120                 125             


Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Gln Ser Gly Pro Glu Leu 
145                 150                 155                 160 


Glu Lys Pro Gly Ala Ser Val Met Ile Ser Cys Lys Ala Ser Gly Ser 
                165                 170                 175     


Ser Phe Thr Gly Tyr Asn Met Asn Trp Val Arg Gln Asn Ile Gly Lys 
            180                 185                 190         


Ser Leu Glu Trp Ile Gly Ala Ile Asp Pro Tyr Tyr Gly Gly Thr Ser 
        195                 200                 205             


Tyr Asn Gln Lys Phe Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser 
    210                 215                 220                 


Ser Ser Thr Ala Tyr Met His Leu Lys Ser Leu Thr Ser Glu Asp Ser 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Val Ser Gly Met Glu Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Ser Val Thr Val Ser Ser Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu 
            260                 265                 270         


Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His 
        275                 280                 285             


Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val 
    290                 295                 300                 


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
305                 310                 315                 320 


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
                325                 330                 335     


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
            340                 345                 350         


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
        355                 360                 365             


Ser 
    


<210>  22
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC2-BBz

<400>  22

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ile Ser Glu Phe 
        35                  40                  45              


Thr Tyr Lys Asn Thr Cys Val Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Arg Glu Gly Val Ala Ala Ile Asp Ser Asp Gly Asn Thr Asn Tyr 
65                  70                  75                  80  


Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Met Tyr Tyr Cys Ala Ala Gly Ala Tyr Cys Gly Arg Leu Leu Leu Trp 
        115                 120                 125             


Ile Gly Asn Tyr Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
145                 150                 155                 160 


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
                165                 170                 175     


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
            180                 185                 190         


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
        195                 200                 205             


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
    210                 215                 220                 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
225                 230                 235                 240 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
            260                 265                 270         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        275                 280                 285             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    290                 295                 300                 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
305                 310                 315                 320 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                325                 330                 335     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            340                 345                 350         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360                 365             


<210>  23
<211>  759
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC2-BBz/GD2-28

<400>  23

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ile Ser Glu Phe 
        35                  40                  45              


Thr Tyr Lys Asn Thr Cys Val Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Arg Glu Gly Val Ala Ala Ile Asp Ser Asp Gly Asn Thr Asn Tyr 
65                  70                  75                  80  


Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Met Tyr Tyr Cys Ala Ala Gly Ala Tyr Cys Gly Arg Leu Leu Leu Trp 
        115                 120                 125             


Ile Gly Asn Tyr Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
145                 150                 155                 160 


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
                165                 170                 175     


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
            180                 185                 190         


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
        195                 200                 205             


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
    210                 215                 220                 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
225                 230                 235                 240 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
            260                 265                 270         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        275                 280                 285             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    290                 295                 300                 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
305                 310                 315                 320 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                325                 330                 335     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            340                 345                 350         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360                 365             


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
    370                 375                 380                 


Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu 
385                 390                 395                 400 


Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Glu Ile Val Met Thr 
                405                 410                 415     


Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu 
            420                 425                 430         


Ser Cys Arg Ser Ser Gln Ser Leu Val His Arg Asn Gly Asn Thr Tyr 
        435                 440                 445             


Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
    450                 455                 460                 


His Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly 
465                 470                 475                 480 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
                485                 490                 495     


Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro Pro 
            500                 505                 510         


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu 
    530                 535                 540                 


Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala Ser Val Met Ile Ser 
545                 550                 555                 560 


Cys Lys Ala Ser Gly Ser Ser Phe Thr Gly Tyr Asn Met Asn Trp Val 
                565                 570                 575     


Arg Gln Asn Ile Gly Lys Ser Leu Glu Trp Ile Gly Ala Ile Asp Pro 
            580                 585                 590         


Tyr Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys Gly Arg Ala Thr 
        595                 600                 605             


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met His Leu Lys Ser 
    610                 615                 620                 


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Val Ser Gly Met Glu 
625                 630                 635                 640 


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ile Glu Val Met 
                645                 650                 655     


Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile 
            660                 665                 670         


His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro 
        675                 680                 685             


Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
    690                 695                 700                 


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
705                 710                 715                 720 


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
                725                 730                 735     


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
            740                 745                 750         


Asp Phe Ala Ala Tyr Arg Ser 
        755                 


<210>  24
<211>  759
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC2-28z/GD2-BB

<400>  24

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ile Ser Glu Phe 
        35                  40                  45              


Thr Tyr Lys Asn Thr Cys Val Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Arg Glu Gly Val Ala Ala Ile Asp Ser Asp Gly Asn Thr Asn Tyr 
65                  70                  75                  80  


Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Met Tyr Tyr Cys Ala Ala Gly Ala Tyr Cys Gly Arg Leu Leu Leu Trp 
        115                 120                 125             


Ile Gly Asn Tyr Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
145                 150                 155                 160 


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
                165                 170                 175     


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
            180                 185                 190         


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
        195                 200                 205             


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
    210                 215                 220                 


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
225                 230                 235                 240 


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe 
                245                 250                 255     


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
            260                 265                 270         


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
        275                 280                 285             


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
    290                 295                 300                 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
305                 310                 315                 320 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
                325                 330                 335     


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
            340                 345                 350         


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala 
        355                 360                 365             


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
    370                 375                 380                 


Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
385                 390                 395                 400 


Leu Leu His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala 
                405                 410                 415     


Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ser 
            420                 425                 430         


Ser Gln Ser Leu Val His Arg Asn Gly Asn Thr Tyr Leu His Trp Tyr 
        435                 440                 445             


Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile His Lys Val Ser 
    450                 455                 460                 


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly 
                485                 490                 495     


Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro Pro Leu Thr Phe Gly 
            500                 505                 510         


Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly Gly Gly 
        515                 520                 525             


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Gln Ser Gly Pro 
    530                 535                 540                 


Glu Leu Glu Lys Pro Gly Ala Ser Val Met Ile Ser Cys Lys Ala Ser 
545                 550                 555                 560 


Gly Ser Ser Phe Thr Gly Tyr Asn Met Asn Trp Val Arg Gln Asn Ile 
                565                 570                 575     


Gly Lys Ser Leu Glu Trp Ile Gly Ala Ile Asp Pro Tyr Tyr Gly Gly 
            580                 585                 590         


Thr Ser Tyr Asn Gln Lys Phe Lys Gly Arg Ala Thr Leu Thr Val Asp 
        595                 600                 605             


Lys Ser Ser Ser Thr Ala Tyr Met His Leu Lys Ser Leu Thr Ser Glu 
    610                 615                 620                 


Asp Ser Ala Val Tyr Tyr Cys Val Ser Gly Met Glu Tyr Trp Gly Gln 
625                 630                 635                 640 


Gly Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro 
                645                 650                 655     


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
            660                 665                 670         


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
        675                 680                 685             


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
    690                 695                 700                 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
705                 710                 715                 720 


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
                725                 730                 735     


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
            740                 745                 750         


Glu Glu Gly Gly Cys Glu Leu 
        755                 


<210>  25
<211>  833
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC2-BBz/GD2-CD2

<400>  25

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ile Ser Glu Phe 
        35                  40                  45              


Thr Tyr Lys Asn Thr Cys Val Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Arg Glu Gly Val Ala Ala Ile Asp Ser Asp Gly Asn Thr Asn Tyr 
65                  70                  75                  80  


Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Met Tyr Tyr Cys Ala Ala Gly Ala Tyr Cys Gly Arg Leu Leu Leu Trp 
        115                 120                 125             


Ile Gly Asn Tyr Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
145                 150                 155                 160 


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
                165                 170                 175     


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
            180                 185                 190         


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
        195                 200                 205             


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
    210                 215                 220                 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
225                 230                 235                 240 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
            260                 265                 270         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        275                 280                 285             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    290                 295                 300                 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
305                 310                 315                 320 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                325                 330                 335     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            340                 345                 350         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360                 365             


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
    370                 375                 380                 


Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu 
385                 390                 395                 400 


Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Glu Ile Val Met Thr 
                405                 410                 415     


Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu 
            420                 425                 430         


Ser Cys Arg Ser Ser Gln Ser Leu Val His Arg Asn Gly Asn Thr Tyr 
        435                 440                 445             


Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
    450                 455                 460                 


His Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly 
465                 470                 475                 480 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
                485                 490                 495     


Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro Pro 
            500                 505                 510         


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu 
    530                 535                 540                 


Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala Ser Val Met Ile Ser 
545                 550                 555                 560 


Cys Lys Ala Ser Gly Ser Ser Phe Thr Gly Tyr Asn Met Asn Trp Val 
                565                 570                 575     


Arg Gln Asn Ile Gly Lys Ser Leu Glu Trp Ile Gly Ala Ile Asp Pro 
            580                 585                 590         


Tyr Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys Gly Arg Ala Thr 
        595                 600                 605             


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met His Leu Lys Ser 
    610                 615                 620                 


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Val Ser Gly Met Glu 
625                 630                 635                 640 


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ile Glu Val Met 
                645                 650                 655     


Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile 
            660                 665                 670         


His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro 
        675                 680                 685             


Ser Lys Pro Ile Tyr Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu 
    690                 695                 700                 


Leu Met Val Phe Val Ala Leu Leu Val Phe Tyr Ile Thr Lys Arg Lys 
705                 710                 715                 720 


Lys Gln Arg Ser Arg Arg Asn Asp Glu Glu Leu Glu Thr Arg Ala His 
                725                 730                 735     


Arg Val Ala Thr Glu Glu Arg Gly Arg Lys Pro His Gln Ile Pro Ala 
            740                 745                 750         


Ser Thr Pro Gln Asn Pro Ala Thr Ser Gln His Pro Pro Pro Pro Pro 
        755                 760                 765             


Gly His Arg Ser Gln Ala Pro Ser His Arg Pro Pro Pro Pro Gly His 
    770                 775                 780                 


Arg Val Gln His Gln Pro Gln Lys Arg Pro Pro Ala Pro Ser Gly Thr 
785                 790                 795                 800 


Gln Val His Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro Arg Val Gln 
                805                 810                 815     


Pro Lys Pro Pro His Gly Ala Ala Glu Asn Ser Leu Ser Pro Ser Ser 
            820                 825                 830         


Asn 
    


<210>  26
<211>  750
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC2-BBz/GD2-ICOS

<400>  26

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ile Ser Glu Phe 
        35                  40                  45              


Thr Tyr Lys Asn Thr Cys Val Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Arg Glu Gly Val Ala Ala Ile Asp Ser Asp Gly Asn Thr Asn Tyr 
65                  70                  75                  80  


Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Met Tyr Tyr Cys Ala Ala Gly Ala Tyr Cys Gly Arg Leu Leu Leu Trp 
        115                 120                 125             


Ile Gly Asn Tyr Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
145                 150                 155                 160 


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
                165                 170                 175     


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
            180                 185                 190         


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
        195                 200                 205             


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
    210                 215                 220                 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
225                 230                 235                 240 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
            260                 265                 270         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        275                 280                 285             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    290                 295                 300                 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
305                 310                 315                 320 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                325                 330                 335     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            340                 345                 350         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360                 365             


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
    370                 375                 380                 


Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu 
385                 390                 395                 400 


Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Glu Ile Val Met Thr 
                405                 410                 415     


Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu 
            420                 425                 430         


Ser Cys Arg Ser Ser Gln Ser Leu Val His Arg Asn Gly Asn Thr Tyr 
        435                 440                 445             


Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
    450                 455                 460                 


His Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly 
465                 470                 475                 480 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
                485                 490                 495     


Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro Pro 
            500                 505                 510         


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu 
    530                 535                 540                 


Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala Ser Val Met Ile Ser 
545                 550                 555                 560 


Cys Lys Ala Ser Gly Ser Ser Phe Thr Gly Tyr Asn Met Asn Trp Val 
                565                 570                 575     


Arg Gln Asn Ile Gly Lys Ser Leu Glu Trp Ile Gly Ala Ile Asp Pro 
            580                 585                 590         


Tyr Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys Gly Arg Ala Thr 
        595                 600                 605             


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met His Leu Lys Ser 
    610                 615                 620                 


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Val Ser Gly Met Glu 
625                 630                 635                 640 


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ile Glu Val Met 
                645                 650                 655     


Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile 
            660                 665                 670         


His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro 
        675                 680                 685             


Ser Lys Pro Phe Trp Leu Pro Ile Gly Cys Ala Ala Phe Val Val Val 
    690                 695                 700                 


Cys Ile Leu Gly Cys Ile Leu Ile Cys Trp Leu Thr Lys Lys Lys Tyr 
705                 710                 715                 720 


Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr Met Phe Met Arg Ala 
                725                 730                 735     


Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp Val Thr Leu 
            740                 745                 750 


<210>  27
<211>  759
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GD2-BBz/GPC2-28

<400>  27

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Gln 
        35                  40                  45              


Ser Leu Val His Arg Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile His Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
            100                 105                 110         


Phe Cys Ser Gln Ser Thr His Val Pro Pro Leu Thr Phe Gly Ala Gly 
        115                 120                 125             


Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Gln Ser Gly Pro Glu Leu 
145                 150                 155                 160 


Glu Lys Pro Gly Ala Ser Val Met Ile Ser Cys Lys Ala Ser Gly Ser 
                165                 170                 175     


Ser Phe Thr Gly Tyr Asn Met Asn Trp Val Arg Gln Asn Ile Gly Lys 
            180                 185                 190         


Ser Leu Glu Trp Ile Gly Ala Ile Asp Pro Tyr Tyr Gly Gly Thr Ser 
        195                 200                 205             


Tyr Asn Gln Lys Phe Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser 
    210                 215                 220                 


Ser Ser Thr Ala Tyr Met His Leu Lys Ser Leu Thr Ser Glu Asp Ser 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Val Ser Gly Met Glu Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
            260                 265                 270         


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
        275                 280                 285             


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
    290                 295                 300                 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
305                 310                 315                 320 


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys 
                325                 330                 335     


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
            340                 345                 350         


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
        355                 360                 365             


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            420                 425                 430         


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        435                 440                 445             


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    450                 455                 460                 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
465                 470                 475                 480 


Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
                485                 490                 495     


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val 
            500                 505                 510         


Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro 
        515                 520                 525             


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
    530                 535                 540                 


Ser Leu Arg Leu Ser Cys Ala Ile Ser Glu Phe Thr Tyr Lys Asn Thr 
545                 550                 555                 560 


Cys Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
                565                 570                 575     


Ala Ala Ile Asp Ser Asp Gly Asn Thr Asn Tyr Val Asp Ser Val Lys 
            580                 585                 590         


Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys Asn Thr Val Tyr Leu 
        595                 600                 605             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
    610                 615                 620                 


Ala Gly Ala Tyr Cys Gly Arg Leu Leu Leu Trp Ile Gly Asn Tyr Ala 
625                 630                 635                 640 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ile Glu Val Met 
                645                 650                 655     


Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile 
            660                 665                 670         


His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro 
        675                 680                 685             


Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
    690                 695                 700                 


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
705                 710                 715                 720 


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
                725                 730                 735     


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
            740                 745                 750         


Asp Phe Ala Ala Tyr Arg Ser 
        755                 


<210>  28
<211>  759
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GD2-28z/GPC2-BB

<400>  28

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Gln 
        35                  40                  45              


Ser Leu Val His Arg Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile His Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
            100                 105                 110         


Phe Cys Ser Gln Ser Thr His Val Pro Pro Leu Thr Phe Gly Ala Gly 
        115                 120                 125             


Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Gln Ser Gly Pro Glu Leu 
145                 150                 155                 160 


Glu Lys Pro Gly Ala Ser Val Met Ile Ser Cys Lys Ala Ser Gly Ser 
                165                 170                 175     


Ser Phe Thr Gly Tyr Asn Met Asn Trp Val Arg Gln Asn Ile Gly Lys 
            180                 185                 190         


Ser Leu Glu Trp Ile Gly Ala Ile Asp Pro Tyr Tyr Gly Gly Thr Ser 
        195                 200                 205             


Tyr Asn Gln Lys Phe Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser 
    210                 215                 220                 


Ser Ser Thr Ala Tyr Met His Leu Lys Ser Leu Thr Ser Glu Asp Ser 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Val Ser Gly Met Glu Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Ser Val Thr Val Ser Ser Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu 
            260                 265                 270         


Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His 
        275                 280                 285             


Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val 
    290                 295                 300                 


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
305                 310                 315                 320 


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
                325                 330                 335     


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
            340                 345                 350         


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
        355                 360                 365             


Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
    370                 375                 380                 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
385                 390                 395                 400 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
                405                 410                 415     


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
            420                 425                 430         


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
        435                 440                 445             


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
    450                 455                 460                 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
465                 470                 475                 480 


Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
                485                 490                 495     


Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu 
            500                 505                 510         


Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Glu Val Gln Leu 
        515                 520                 525             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    530                 535                 540                 


Ser Cys Ala Ile Ser Glu Phe Thr Tyr Lys Asn Thr Cys Val Gly Trp 
545                 550                 555                 560 


Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val Ala Ala Ile Asp 
                565                 570                 575     


Ser Asp Gly Asn Thr Asn Tyr Val Asp Ser Val Lys Gly Arg Phe Thr 
            580                 585                 590         


Ile Ser Gln Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser 
        595                 600                 605             


Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala Gly Ala Tyr 
    610                 615                 620                 


Cys Gly Arg Leu Leu Leu Trp Ile Gly Asn Tyr Ala Tyr Trp Gly Gln 
625                 630                 635                 640 


Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro 
                645                 650                 655     


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
            660                 665                 670         


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
        675                 680                 685             


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
    690                 695                 700                 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
705                 710                 715                 720 


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
                725                 730                 735     


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
            740                 745                 750         


Glu Glu Gly Gly Cys Glu Leu 
        755                 


<210>  29
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLL3-BBz

<400>  29

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Phe Ser 
        35                  40                  45              


Gly Tyr Gly Val Ser Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Gly Val Ala Ala Ile Thr Val Gly Ser Gly Asn Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Val Gly Tyr Leu Ser Gly Gly Ser Trp Asp 
        115                 120                 125             


Val Pro Gly Arg Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
                165                 170                 175     


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Thr Tyr Ser Ser 
            180                 185                 190         


Asn Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Glu 
        195                 200                 205             


Val Ala Val Ile Tyr Thr Arg Gly Gly His Thr Tyr Tyr Val Asp Ser 
    210                 215                 220                 


Val Arg Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Ser Leu 
225                 230                 235                 240 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                245                 250                 255     


Cys Ala Ala Ser Ser Arg His Arg Leu Gly Leu Asn Asn Pro Arg Asp 
            260                 265                 270         


Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                325                 330                 335     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            340                 345                 350         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  30
<211>  923
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLL3-BBz/DLL3-28

<400>  30

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Phe Ser 
        35                  40                  45              


Gly Tyr Gly Val Ser Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Gly Val Ala Ala Ile Thr Val Gly Ser Gly Asn Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Val Gly Tyr Leu Ser Gly Gly Ser Trp Asp 
        115                 120                 125             


Val Pro Gly Arg Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
                165                 170                 175     


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Thr Tyr Ser Ser 
            180                 185                 190         


Asn Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Glu 
        195                 200                 205             


Val Ala Val Ile Tyr Thr Arg Gly Gly His Thr Tyr Tyr Val Asp Ser 
    210                 215                 220                 


Val Arg Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Ser Leu 
225                 230                 235                 240 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                245                 250                 255     


Cys Ala Ala Ser Ser Arg His Arg Leu Gly Leu Asn Asn Pro Arg Asp 
            260                 265                 270         


Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                325                 330                 335     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            340                 345                 350         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly 
            500                 505                 510         


Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
        515                 520                 525             


Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
    530                 535                 540                 


Leu Leu His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly 
545                 550                 555                 560 


Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                565                 570                 575     


Phe Ser Gly Tyr Gly Val Ser Thr Met Ala Trp Phe Arg Gln Ala Pro 
            580                 585                 590         


Gly Lys Gly Leu Glu Gly Val Ala Ala Ile Thr Val Gly Ser Gly Asn 
        595                 600                 605             


Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    610                 615                 620                 


Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
625                 630                 635                 640 


Asp Thr Ala Met Tyr Tyr Cys Ala Val Gly Tyr Leu Ser Gly Gly Ser 
                645                 650                 655     


Trp Asp Val Pro Gly Arg Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val 
            660                 665                 670         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        675                 680                 685             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    690                 695                 700                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Thr Tyr 
705                 710                 715                 720 


Ser Ser Asn Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu 
                725                 730                 735     


Glu Glu Val Ala Val Ile Tyr Thr Arg Gly Gly His Thr Tyr Tyr Val 
            740                 745                 750         


Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn 
        755                 760                 765             


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
    770                 775                 780                 


Tyr Tyr Cys Ala Ala Ser Ser Arg His Arg Leu Gly Leu Asn Asn Pro 
785                 790                 795                 800 


Arg Asp Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                805                 810                 815     


Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
            820                 825                 830         


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
        835                 840                 845             


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
    850                 855                 860                 


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
865                 870                 875                 880 


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
                885                 890                 895     


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
            900                 905                 910         


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        915                 920             


<210>  31
<211>  912
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLL3-BBz/CD326-28

<400>  31

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Phe Ser 
        35                  40                  45              


Gly Tyr Gly Val Ser Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Gly Val Ala Ala Ile Thr Val Gly Ser Gly Asn Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Val Gly Tyr Leu Ser Gly Gly Ser Trp Asp 
        115                 120                 125             


Val Pro Gly Arg Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
                165                 170                 175     


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Thr Tyr Ser Ser 
            180                 185                 190         


Asn Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Glu 
        195                 200                 205             


Val Ala Val Ile Tyr Thr Arg Gly Gly His Thr Tyr Tyr Val Asp Ser 
    210                 215                 220                 


Val Arg Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Ser Leu 
225                 230                 235                 240 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                245                 250                 255     


Cys Ala Ala Ser Ser Arg His Arg Leu Gly Leu Asn Asn Pro Arg Asp 
            260                 265                 270         


Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                325                 330                 335     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            340                 345                 350         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly 
            500                 505                 510         


Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
        515                 520                 525             


Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
    530                 535                 540                 


Leu Leu His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser 
545                 550                 555                 560 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ser 
                565                 570                 575     


Thr Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr 
            580                 585                 590         


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gln Met Ser 
        595                 600                 605             


Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Ser Ser Gly Ser Gly 
    610                 615                 620                 


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
625                 630                 635                 640 


Thr Tyr Tyr Cys Ala Gln Asn Leu Glu Ile Pro Arg Thr Phe Gly Gln 
                645                 650                 655     


Gly Thr Lys Val Glu Leu Lys Arg Ala Thr Pro Ser His Asn Ser His 
            660                 665                 670         


Gln Val Pro Ser Ala Gly Gly Pro Thr Ala Asn Ser Gly Thr Ser Gly 
        675                 680                 685             


Ser Glu Val Gln Leu Val Gln Ser Gly Pro Gly Leu Val Gln Pro Gly 
    690                 695                 700                 


Gly Ser Val Arg Ile Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn 
705                 710                 715                 720 


Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                725                 730                 735     


Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ala Asp Ser 
            740                 745                 750         


Phe Lys Gly Arg Phe Thr Phe Ser Leu Asp Thr Ser Ala Ser Ala Ala 
        755                 760                 765             


Tyr Leu Gln Ile Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
    770                 775                 780                 


Cys Ala Arg Phe Ala Ile Lys Gly Asp Tyr Trp Gly Gln Gly Thr Leu 
785                 790                 795                 800 


Leu Thr Val Ser Ser Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp 
                805                 810                 815     


Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu 
            820                 825                 830         


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
        835                 840                 845             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    850                 855                 860                 


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
865                 870                 875                 880 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
                885                 890                 895     


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            900                 905                 910         


<210>  32
<211>  899
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLL3-BBz/GD2-28

<400>  32

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Phe Ser 
        35                  40                  45              


Gly Tyr Gly Val Ser Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Gly Val Ala Ala Ile Thr Val Gly Ser Gly Asn Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Val Gly Tyr Leu Ser Gly Gly Ser Trp Asp 
        115                 120                 125             


Val Pro Gly Arg Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
                165                 170                 175     


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Thr Tyr Ser Ser 
            180                 185                 190         


Asn Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Glu 
        195                 200                 205             


Val Ala Val Ile Tyr Thr Arg Gly Gly His Thr Tyr Tyr Val Asp Ser 
    210                 215                 220                 


Val Arg Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Ser Leu 
225                 230                 235                 240 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                245                 250                 255     


Cys Ala Ala Ser Ser Arg His Arg Leu Gly Leu Asn Asn Pro Arg Asp 
            260                 265                 270         


Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                325                 330                 335     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            340                 345                 350         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly 
            500                 505                 510         


Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
        515                 520                 525             


Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
    530                 535                 540                 


Leu Leu His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala 
545                 550                 555                 560 


Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ser 
                565                 570                 575     


Ser Gln Ser Leu Val His Arg Asn Gly Asn Thr Tyr Leu His Trp Tyr 
            580                 585                 590         


Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile His Lys Val Ser 
        595                 600                 605             


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    610                 615                 620                 


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly 
625                 630                 635                 640 


Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro Pro Leu Thr Phe Gly 
                645                 650                 655     


Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly Gly Gly 
            660                 665                 670         


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Gln Ser Gly Pro 
        675                 680                 685             


Glu Leu Glu Lys Pro Gly Ala Ser Val Met Ile Ser Cys Lys Ala Ser 
    690                 695                 700                 


Gly Ser Ser Phe Thr Gly Tyr Asn Met Asn Trp Val Arg Gln Asn Ile 
705                 710                 715                 720 


Gly Lys Ser Leu Glu Trp Ile Gly Ala Ile Asp Pro Tyr Tyr Gly Gly 
                725                 730                 735     


Thr Ser Tyr Asn Gln Lys Phe Lys Gly Arg Ala Thr Leu Thr Val Asp 
            740                 745                 750         


Lys Ser Ser Ser Thr Ala Tyr Met His Leu Lys Ser Leu Thr Ser Glu 
        755                 760                 765             


Asp Ser Ala Val Tyr Tyr Cys Val Ser Gly Met Glu Tyr Trp Gly Gln 
    770                 775                 780                 


Gly Thr Ser Val Thr Val Ser Ser Ile Glu Val Met Tyr Pro Pro Pro 
785                 790                 795                 800 


Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly 
                805                 810                 815     


Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
            820                 825                 830         


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
        835                 840                 845             


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
    850                 855                 860                 


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
865                 870                 875                 880 


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
                885                 890                 895     


Tyr Arg Ser 
            


<210>  33
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A element

<400>  33

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  34
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 (C141S) hinge

<400>  34

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Ser Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro 
        35                  


<210>  35
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 (C168S) transmembrane domain

<400>  35

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Ser Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  36
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enoblituzumab variable light chain

<400>  36

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  37
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enoblituzumab variable heavy chain

<400>  37

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Asp Ser Ser Ala Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Gly Arg Glu Asn Ile Tyr Tyr Gly Ser Arg Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  38
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-MSLN VHH

<400>  38

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Ser Phe Ser Thr Tyr 
            20                  25                  30          


Thr Val Ala Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Pro Tyr Thr Ser Gln His Met Val Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Arg Arg Pro Gly Thr Ser Met Leu Ala Ile Asn Gly Tyr 
            100                 105                 110         


Asn Arg Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  39
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-GPC2 VHH

<400>  39

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ile Ser Glu Phe Thr Tyr Lys Asn Thr 
            20                  25                  30          


Cys Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Asp Gly Asn Thr Asn Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Ala Tyr Cys Gly Arg Leu Leu Leu Trp Ile Gly Asn Tyr Ala 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  40
<211>  364
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC2-28z

<400>  40

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ile Ser Glu Phe 
        35                  40                  45              


Thr Tyr Lys Asn Thr Cys Val Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Arg Glu Gly Val Ala Ala Ile Asp Ser Asp Gly Asn Thr Asn Tyr 
65                  70                  75                  80  


Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Met Tyr Tyr Cys Ala Ala Gly Ala Tyr Cys Gly Arg Leu Leu Leu Trp 
        115                 120                 125             


Ile Gly Asn Tyr Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
145                 150                 155                 160 


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
                165                 170                 175     


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
            180                 185                 190         


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
        195                 200                 205             


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
    210                 215                 220                 


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
225                 230                 235                 240 


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe 
                245                 250                 255     


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
            260                 265                 270         


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
        275                 280                 285             


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
    290                 295                 300                 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
305                 310                 315                 320 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
                325                 330                 335     


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
            340                 345                 350         


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360                 


<210>  41
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MSLN-BBz

<400>  41

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu 
        35                  40                  45              


Ser Phe Ser Thr Tyr Thr Val Ala Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Gly Val Ala Ala Ile Pro Tyr Thr Ser Gln His Met Val 
65                  70                  75                  80  


Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Thr Asp Arg Arg Pro Gly Thr Ser Met Leu 
        115                 120                 125             


Ala Ile Asn Gly Tyr Asn Arg Trp Gly Gln Gly Thr Thr Val Thr Val 
    130                 135                 140                 


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
145                 150                 155                 160 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
                165                 170                 175     


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
            180                 185                 190         


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
        195                 200                 205             


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
    210                 215                 220                 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
225                 230                 235                 240 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
                245                 250                 255     


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
            260                 265                 270         


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
        275                 280                 285             


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
    290                 295                 300                 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
305                 310                 315                 320 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                325                 330                 335     


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            340                 345                 350         


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        355                 360                 365             


Arg 
    


<210>  42
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC2-BB28z

<400>  42

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ile Ser Glu Phe 
        35                  40                  45              


Thr Tyr Lys Asn Thr Cys Val Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Arg Glu Gly Val Ala Ala Ile Asp Ser Asp Gly Asn Thr Asn Tyr 
65                  70                  75                  80  


Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Met Tyr Tyr Cys Ala Ala Gly Ala Tyr Cys Gly Arg Leu Leu Leu Trp 
        115                 120                 125             


Ile Gly Asn Tyr Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
145                 150                 155                 160 


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
                165                 170                 175     


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
            180                 185                 190         


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
        195                 200                 205             


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
    210                 215                 220                 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
225                 230                 235                 240 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255     


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
            260                 265                 270         


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
        275                 280                 285             


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
    290                 295                 300                 


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
305                 310                 315                 320 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                325                 330                 335     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            340                 345                 350         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        355                 360                 365             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    370                 375                 380                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
385                 390                 395                 400 


Leu His Met Gln Ala Leu Pro Pro Arg 
                405                 


<210>  43
<211>  405
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC2-28BBz

<400>  43

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ile Ser Glu Phe 
        35                  40                  45              


Thr Tyr Lys Asn Thr Cys Val Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Arg Glu Gly Val Ala Ala Ile Asp Ser Asp Gly Asn Thr Asn Tyr 
65                  70                  75                  80  


Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Met Tyr Tyr Cys Ala Ala Gly Ala Tyr Cys Gly Arg Leu Leu Leu Trp 
        115                 120                 125             


Ile Gly Asn Tyr Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
145                 150                 155                 160 


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
                165                 170                 175     


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
            180                 185                 190         


Gly Val Leu Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
        195                 200                 205             


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
    210                 215                 220                 


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
225                 230                 235                 240 


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys 
                245                 250                 255     


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
            260                 265                 270         


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
        275                 280                 285             


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    290                 295                 300                 


Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
305                 310                 315                 320 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                325                 330                 335     


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            340                 345                 350         


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        355                 360                 365             


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    370                 375                 380                 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
385                 390                 395                 400 


Ala Leu Pro Pro Arg 
                405 


<210>  44
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC2-28OX40z

<400>  44

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ile Ser Glu Phe 
        35                  40                  45              


Thr Tyr Lys Asn Thr Cys Val Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Arg Glu Gly Val Ala Ala Ile Asp Ser Asp Gly Asn Thr Asn Tyr 
65                  70                  75                  80  


Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Met Tyr Tyr Cys Ala Ala Gly Ala Tyr Cys Gly Arg Leu Leu Leu Trp 
        115                 120                 125             


Ile Gly Asn Tyr Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
145                 150                 155                 160 


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
                165                 170                 175     


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
            180                 185                 190         


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
        195                 200                 205             


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
    210                 215                 220                 


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
225                 230                 235                 240 


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Ala Leu Tyr Leu 
                245                 250                 255     


Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly 
            260                 265                 270         


Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His 
        275                 280                 285             


Ser Thr Leu Ala Lys Ile Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    290                 295                 300                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
305                 310                 315                 320 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                325                 330                 335     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            340                 345                 350         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        355                 360                 365             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    370                 375                 380                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
385                 390                 395                 400 


Gln Ala Leu Pro Pro Arg 
                405     


<210>  45
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC2-2827z

<400>  45

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ile Ser Glu Phe 
        35                  40                  45              


Thr Tyr Lys Asn Thr Cys Val Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Arg Glu Gly Val Ala Ala Ile Asp Ser Asp Gly Asn Thr Asn Tyr 
65                  70                  75                  80  


Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Met Tyr Tyr Cys Ala Ala Gly Ala Tyr Cys Gly Arg Leu Leu Leu Trp 
        115                 120                 125             


Ile Gly Asn Tyr Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
145                 150                 155                 160 


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
                165                 170                 175     


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
            180                 185                 190         


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
        195                 200                 205             


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
    210                 215                 220                 


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
225                 230                 235                 240 


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Gln Arg Arg Lys 
                245                 250                 255     


Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro Ala Glu Pro Cys 
            260                 265                 270         


His Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr Ile Pro Ile Gln 
        275                 280                 285             


Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro Arg Val Lys Phe 
    290                 295                 300                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
305                 310                 315                 320 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                325                 330                 335     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            340                 345                 350         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        355                 360                 365             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    370                 375                 380                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
385                 390                 395                 400 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                405                 410         


<210>  46
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD326-28

<400>  46

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ser Thr Lys 
        35                  40                  45              


Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gln Met Ser Asn Leu 
65                  70                  75                  80  


Ala Ser Gly Val Pro Ser Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Ala Gln Asn Leu Glu Ile Pro Arg Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Val Glu Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Pro Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Val Arg Ile Ser Cys Ala Ala Ser Gly Tyr 
                165                 170                 175     


Thr Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr 
        195                 200                 205             


Tyr Ala Asp Ser Phe Lys Gly Arg Phe Thr Phe Ser Leu Asp Thr Ser 
    210                 215                 220                 


Ala Ser Ala Ala Tyr Leu Gln Ile Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Phe Ala Ile Lys Gly Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Leu Thr Val Ser Ser Ile Glu Val Met Tyr Pro Pro 
            260                 265                 270         


Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys 
        275                 280                 285             


Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro 
    290                 295                 300                 


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
305                 310                 315                 320 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
                325                 330                 335     


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
            340                 345                 350         


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
        355                 360                 365             


Ala Tyr Arg Ser 
    370         


<210>  47
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MSLN-28

<400>  47

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu 
        35                  40                  45              


Ser Phe Ser Thr Tyr Thr Val Ala Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Gly Val Ala Ala Ile Pro Tyr Thr Ser Gln His Met Val 
65                  70                  75                  80  


Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Thr Asp Arg Arg Pro Gly Thr Ser Met Leu 
        115                 120                 125             


Ala Ile Asn Gly Tyr Asn Arg Trp Gly Gln Gly Thr Thr Val Thr Val 
    130                 135                 140                 


Ser Ser Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys 
145                 150                 155                 160 


Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser 
                165                 170                 175     


Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val 
            180                 185                 190         


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
        195                 200                 205             


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
    210                 215                 220                 


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
225                 230                 235                 240 


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
                245                 250             


<210>  48
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLL3-28

<400>  48

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Phe Ser 
        35                  40                  45              


Gly Tyr Gly Val Ser Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Gly Val Ala Ala Ile Thr Val Gly Ser Gly Asn Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Val Gly Tyr Leu Ser Gly Gly Ser Trp Asp 
        115                 120                 125             


Val Pro Gly Arg Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
                165                 170                 175     


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Thr Tyr Ser Ser 
            180                 185                 190         


Asn Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Glu 
        195                 200                 205             


Val Ala Val Ile Tyr Thr Arg Gly Gly His Thr Tyr Tyr Val Asp Ser 
    210                 215                 220                 


Val Arg Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Ser Leu 
225                 230                 235                 240 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                245                 250                 255     


Cys Ala Ala Ser Ser Arg His Arg Leu Gly Leu Asn Asn Pro Arg Asp 
            260                 265                 270         


Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ile Glu 
        275                 280                 285             


Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr 
    290                 295                 300                 


Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro 
305                 310                 315                 320 


Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
                325                 330                 335     


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            340                 345                 350         


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
        355                 360                 365             


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
    370                 375                 380                 


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
385                 390             


<210>  49
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GD2-28 (C141S, C168S mutant)

<400>  49

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Gln 
        35                  40                  45              


Ser Leu Val His Arg Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile His Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
            100                 105                 110         


Phe Cys Ser Gln Ser Thr His Val Pro Pro Leu Thr Phe Gly Ala Gly 
        115                 120                 125             


Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Gln Ser Gly Pro Glu Leu 
145                 150                 155                 160 


Glu Lys Pro Gly Ala Ser Val Met Ile Ser Cys Lys Ala Ser Gly Ser 
                165                 170                 175     


Ser Phe Thr Gly Tyr Asn Met Asn Trp Val Arg Gln Asn Ile Gly Lys 
            180                 185                 190         


Ser Leu Glu Trp Ile Gly Ala Ile Asp Pro Tyr Tyr Gly Gly Thr Ser 
        195                 200                 205             


Tyr Asn Gln Lys Phe Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser 
    210                 215                 220                 


Ser Ser Thr Ala Tyr Met His Leu Lys Ser Leu Thr Ser Glu Asp Ser 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Val Ser Gly Met Glu Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Ser Val Thr Val Ser Ser Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu 
            260                 265                 270         


Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His 
        275                 280                 285             


Leu Ser Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val 
    290                 295                 300                 


Leu Val Val Val Gly Gly Val Leu Ala Ser Tyr Ser Leu Leu Val Thr 
305                 310                 315                 320 


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
                325                 330                 335     


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
            340                 345                 350         


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
        355                 360                 365             


Ser 
    


<210>  50
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MSLN-28 (C141S, C168S mutant)

<400>  50

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu 
        35                  40                  45              


Ser Phe Ser Thr Tyr Thr Val Ala Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Gly Val Ala Ala Ile Pro Tyr Thr Ser Gln His Met Val 
65                  70                  75                  80  


Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Thr Asp Arg Arg Pro Gly Thr Ser Met Leu 
        115                 120                 125             


Ala Ile Asn Gly Tyr Asn Arg Trp Gly Gln Gly Thr Thr Val Thr Val 
    130                 135                 140                 


Ser Ser Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys 
145                 150                 155                 160 


Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Ser Pro Ser 
                165                 170                 175     


Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val 
            180                 185                 190         


Gly Gly Val Leu Ala Ser Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
        195                 200                 205             


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
    210                 215                 220                 


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
225                 230                 235                 240 


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
                245                 250             


<210>  51
<211>  643
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC2-BBz/MSLN-28

<400>  51

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ile Ser Glu Phe 
        35                  40                  45              


Thr Tyr Lys Asn Thr Cys Val Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Arg Glu Gly Val Ala Ala Ile Asp Ser Asp Gly Asn Thr Asn Tyr 
65                  70                  75                  80  


Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Met Tyr Tyr Cys Ala Ala Gly Ala Tyr Cys Gly Arg Leu Leu Leu Trp 
        115                 120                 125             


Ile Gly Asn Tyr Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
145                 150                 155                 160 


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
                165                 170                 175     


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
            180                 185                 190         


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
        195                 200                 205             


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
    210                 215                 220                 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
225                 230                 235                 240 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
            260                 265                 270         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        275                 280                 285             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    290                 295                 300                 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
305                 310                 315                 320 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                325                 330                 335     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            340                 345                 350         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360                 365             


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
    370                 375                 380                 


Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu 
385                 390                 395                 400 


Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Gln Val Gln Leu Val 
                405                 410                 415     


Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
            420                 425                 430         


Cys Ala Ala Ser Gly Leu Ser Phe Ser Thr Tyr Thr Val Ala Trp Phe 
        435                 440                 445             


Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val Ala Ala Ile Pro Tyr 
    450                 455                 460                 


Thr Ser Gln His Met Val Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr 
465                 470                 475                 480 


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
                485                 490                 495     


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr Asp Arg Arg 
            500                 505                 510         


Pro Gly Thr Ser Met Leu Ala Ile Asn Gly Tyr Asn Arg Trp Gly Gln 
        515                 520                 525             


Gly Thr Thr Val Thr Val Ser Ser Ile Glu Val Met Tyr Pro Pro Pro 
    530                 535                 540                 


Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly 
545                 550                 555                 560 


Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
                565                 570                 575     


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
            580                 585                 590         


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
        595                 600                 605             


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
    610                 615                 620                 


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
625                 630                 635                 640 


Tyr Arg Ser 
            


<210>  52
<211>  923
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLL3-BBz/DLL3-28

<400>  52

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Phe Ser 
        35                  40                  45              


Gly Tyr Gly Val Ser Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Gly Val Ala Ala Ile Thr Val Gly Ser Gly Asn Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Val Gly Tyr Leu Ser Gly Gly Ser Trp Asp 
        115                 120                 125             


Val Pro Gly Arg Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
                165                 170                 175     


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Thr Tyr Ser Ser 
            180                 185                 190         


Asn Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Glu 
        195                 200                 205             


Val Ala Val Ile Tyr Thr Arg Gly Gly His Thr Tyr Tyr Val Asp Ser 
    210                 215                 220                 


Val Arg Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Ser Leu 
225                 230                 235                 240 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                245                 250                 255     


Cys Ala Ala Ser Ser Arg His Arg Leu Gly Leu Asn Asn Pro Arg Asp 
            260                 265                 270         


Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                325                 330                 335     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            340                 345                 350         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly 
            500                 505                 510         


Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
        515                 520                 525             


Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
    530                 535                 540                 


Leu Leu His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly 
545                 550                 555                 560 


Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                565                 570                 575     


Phe Ser Gly Tyr Gly Val Ser Thr Met Ala Trp Phe Arg Gln Ala Pro 
            580                 585                 590         


Gly Lys Gly Leu Glu Gly Val Ala Ala Ile Thr Val Gly Ser Gly Asn 
        595                 600                 605             


Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    610                 615                 620                 


Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
625                 630                 635                 640 


Asp Thr Ala Met Tyr Tyr Cys Ala Val Gly Tyr Leu Ser Gly Gly Ser 
                645                 650                 655     


Trp Asp Val Pro Gly Arg Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val 
            660                 665                 670         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        675                 680                 685             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    690                 695                 700                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Thr Tyr 
705                 710                 715                 720 


Ser Ser Asn Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu 
                725                 730                 735     


Glu Glu Val Ala Val Ile Tyr Thr Arg Gly Gly His Thr Tyr Tyr Val 
            740                 745                 750         


Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn 
        755                 760                 765             


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
    770                 775                 780                 


Tyr Tyr Cys Ala Ala Ser Ser Arg His Arg Leu Gly Leu Asn Asn Pro 
785                 790                 795                 800 


Arg Asp Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                805                 810                 815     


Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
            820                 825                 830         


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
        835                 840                 845             


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
    850                 855                 860                 


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
865                 870                 875                 880 


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
                885                 890                 895     


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
            900                 905                 910         


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        915                 920             


<210>  53
<211>  759
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC2-BBz/GD2-28 (C141S, C168S mutant)

<400>  53

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ile Ser Glu Phe 
        35                  40                  45              


Thr Tyr Lys Asn Thr Cys Val Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Arg Glu Gly Val Ala Ala Ile Asp Ser Asp Gly Asn Thr Asn Tyr 
65                  70                  75                  80  


Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Met Tyr Tyr Cys Ala Ala Gly Ala Tyr Cys Gly Arg Leu Leu Leu Trp 
        115                 120                 125             


Ile Gly Asn Tyr Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
145                 150                 155                 160 


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
                165                 170                 175     


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
            180                 185                 190         


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
        195                 200                 205             


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
    210                 215                 220                 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
225                 230                 235                 240 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
            260                 265                 270         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        275                 280                 285             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    290                 295                 300                 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
305                 310                 315                 320 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                325                 330                 335     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            340                 345                 350         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360                 365             


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
    370                 375                 380                 


Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu 
385                 390                 395                 400 


Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Glu Ile Val Met Thr 
                405                 410                 415     


Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu 
            420                 425                 430         


Ser Cys Arg Ser Ser Gln Ser Leu Val His Arg Asn Gly Asn Thr Tyr 
        435                 440                 445             


Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
    450                 455                 460                 


His Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly 
465                 470                 475                 480 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
                485                 490                 495     


Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro Pro 
            500                 505                 510         


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu 
    530                 535                 540                 


Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala Ser Val Met Ile Ser 
545                 550                 555                 560 


Cys Lys Ala Ser Gly Ser Ser Phe Thr Gly Tyr Asn Met Asn Trp Val 
                565                 570                 575     


Arg Gln Asn Ile Gly Lys Ser Leu Glu Trp Ile Gly Ala Ile Asp Pro 
            580                 585                 590         


Tyr Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys Gly Arg Ala Thr 
        595                 600                 605             


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met His Leu Lys Ser 
    610                 615                 620                 


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Val Ser Gly Met Glu 
625                 630                 635                 640 


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ile Glu Val Met 
                645                 650                 655     


Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile 
            660                 665                 670         


His Val Lys Gly Lys His Leu Ser Pro Ser Pro Leu Phe Pro Gly Pro 
        675                 680                 685             


Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Ser 
    690                 695                 700                 


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
705                 710                 715                 720 


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
                725                 730                 735     


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
            740                 745                 750         


Asp Phe Ala Ala Tyr Arg Ser 
        755                 


<210>  54
<211>  643
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC2-BBz/MSLN-28 (C141S, C168S mutant)

<400>  54

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ile Ser Glu Phe 
        35                  40                  45              


Thr Tyr Lys Asn Thr Cys Val Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Arg Glu Gly Val Ala Ala Ile Asp Ser Asp Gly Asn Thr Asn Tyr 
65                  70                  75                  80  


Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Met Tyr Tyr Cys Ala Ala Gly Ala Tyr Cys Gly Arg Leu Leu Leu Trp 
        115                 120                 125             


Ile Gly Asn Tyr Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
145                 150                 155                 160 


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
                165                 170                 175     


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
            180                 185                 190         


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
        195                 200                 205             


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
    210                 215                 220                 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
225                 230                 235                 240 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
            260                 265                 270         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        275                 280                 285             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    290                 295                 300                 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
305                 310                 315                 320 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                325                 330                 335     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            340                 345                 350         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360                 365             


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
    370                 375                 380                 


Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu 
385                 390                 395                 400 


Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Gln Val Gln Leu Val 
                405                 410                 415     


Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
            420                 425                 430         


Cys Ala Ala Ser Gly Leu Ser Phe Ser Thr Tyr Thr Val Ala Trp Phe 
        435                 440                 445             


Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val Ala Ala Ile Pro Tyr 
    450                 455                 460                 


Thr Ser Gln His Met Val Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr 
465                 470                 475                 480 


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
                485                 490                 495     


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr Asp Arg Arg 
            500                 505                 510         


Pro Gly Thr Ser Met Leu Ala Ile Asn Gly Tyr Asn Arg Trp Gly Gln 
        515                 520                 525             


Gly Thr Thr Val Thr Val Ser Ser Ile Glu Val Met Tyr Pro Pro Pro 
    530                 535                 540                 


Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly 
545                 550                 555                 560 


Lys His Leu Ser Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
                565                 570                 575     


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Ser Tyr Ser Leu Leu 
            580                 585                 590         


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
        595                 600                 605             


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
    610                 615                 620                 


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
625                 630                 635                 640 


Tyr Arg Ser 
            


<210>  55
<211>  720
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC2-BBz/GD2-delta28

<400>  55

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ile Ser Glu Phe 
        35                  40                  45              


Thr Tyr Lys Asn Thr Cys Val Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Arg Glu Gly Val Ala Ala Ile Asp Ser Asp Gly Asn Thr Asn Tyr 
65                  70                  75                  80  


Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Met Tyr Tyr Cys Ala Ala Gly Ala Tyr Cys Gly Arg Leu Leu Leu Trp 
        115                 120                 125             


Ile Gly Asn Tyr Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
145                 150                 155                 160 


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
                165                 170                 175     


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
            180                 185                 190         


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
        195                 200                 205             


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
    210                 215                 220                 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
225                 230                 235                 240 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
            260                 265                 270         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        275                 280                 285             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    290                 295                 300                 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
305                 310                 315                 320 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                325                 330                 335     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            340                 345                 350         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360                 365             


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
    370                 375                 380                 


Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu 
385                 390                 395                 400 


Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Glu Ile Val Met Thr 
                405                 410                 415     


Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu 
            420                 425                 430         


Ser Cys Arg Ser Ser Gln Ser Leu Val His Arg Asn Gly Asn Thr Tyr 
        435                 440                 445             


Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
    450                 455                 460                 


His Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly 
465                 470                 475                 480 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
                485                 490                 495     


Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro Pro 
            500                 505                 510         


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu 
    530                 535                 540                 


Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala Ser Val Met Ile Ser 
545                 550                 555                 560 


Cys Lys Ala Ser Gly Ser Ser Phe Thr Gly Tyr Asn Met Asn Trp Val 
                565                 570                 575     


Arg Gln Asn Ile Gly Lys Ser Leu Glu Trp Ile Gly Ala Ile Asp Pro 
            580                 585                 590         


Tyr Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys Gly Arg Ala Thr 
        595                 600                 605             


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met His Leu Lys Ser 
    610                 615                 620                 


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Val Ser Gly Met Glu 
625                 630                 635                 640 


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ile Glu Val Met 
                645                 650                 655     


Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile 
            660                 665                 670         


His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro 
        675                 680                 685             


Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
    690                 695                 700                 


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
705                 710                 715                 720 


<210>  56
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glycine-serine polymer linker


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  GSGGS can be repeated n times, where n is an integer of at least 
       one

<400>  56

Gly Ser Gly Gly Ser 
1               5   


<210>  57
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glycine-serine polymer linker


<220>
<221>  REPEAT
<222>  (1)..(4)
<223>  GGGS can be repeated n times, where n is an integer of at least 
       one

<400>  57

Gly Gly Gly Ser 
1               


<210>  58
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glycine-serine polymer linker


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  GGGGS can be repeated n times, where n is an integer of at least 
       one

<400>  58

Gly Gly Gly Gly Ser 
1               5   


<210>  59
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  immunoreceptor tyrosine-based inhibitory motif (ITIM)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is S, I, V, or L

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is I, V, or L

<400>  59

Xaa Xaa Tyr Xaa Xaa Xaa 
1               5       


