б

<110>  ϺƼ޹˾

<120>  һֵ׶ǽＰӦ

<130>  0180-PA-003

<160>  8

<170>  PatentIn version 3.5

<210>  1
<211>  487
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  TTD-1

<400>  1

Met Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu 
1                       5                           10                        15      


Lys Lys Leu Glu Ser Lys Ile Asn Lys Val Phe Ser Thr Pro Ile Pro 
                  20                         25                           30          


Phe Ser Tyr Ser Lys Asn Leu Asp Cys Trp Val Asp Asn Glu Glu Asp 
             35                          40                            45              


Ile Asp Val Ile Leu Lys Lys Ser Thr Ile Leu Asn Leu Asp Ile Asn 
      50                        55                        60                  


Asn Asp Ile Ile Ser Asp Ile Ser Gly Phe Asn Ser Ser Val Ile Thr 
65                         70                           75                        80  


Tyr Pro Asp Ala Gln Leu Val Pro Gly Ile Asn Gly Lys Ala Ile His 
                        85                           90                         95      


Leu Val Asn Asn Glu Ser Ser Glu Val Ile Val His Lys Ala Met Asp 
                  100                         105                      110         


Ile Glu Tyr Asn Asp Met Phe Asn Asn Phe Thr Val Ser Phe Trp Leu 
          115                            120                          125             


Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gln Tyr Gly Thr Asn 
      130                        135                        140                 


Glu Tyr Ser Ile Ile Ser Ser Met Lys Lys His Ser Leu Ser Ile Gly 
145                     150                        155                       160 


Ser Gly Trp Ser Val Ser Leu Lys Gly Asn Asn Leu Ile Trp Thr Leu 
                       165                        170                         175     


Lys Asp Ser Ala Gly Glu Val Arg Gln Ile Thr Phe Arg Asp Leu Pro 
                 180                         185                         190         


Asp Lys Phe Asn Ala Tyr Leu Ala Asn Lys Trp Val Phe Ile Thr Ile 
            195                          200                         205             


Thr Asn Asp Arg Leu Ser Ser Ala Asn Leu Tyr Ile Asn Gly Val Leu 
      210                          215                        220                 


Met Gly Ser Ala Glu Ile Thr Gly Leu Gly Ala Ile Arg Glu Asp Asn 
225                        230                        235                         240 


Asn Ile Thr Leu Lys Leu Asp Arg Cys Asn Asn Asn Asn Gln Tyr Val 
                       245                          250                           255     


Ser Ile Asp Lys Phe Arg Ile Phe Cys Lys Ala Leu Asn Pro Lys Glu 
                260                         265                          270         


Ile Glu Lys Leu Tyr Thr Ser Tyr Leu Ser Ile Thr Phe Leu Arg Asp 
          275                        280                        285             


Phe Trp Gly Asn Pro Leu Arg Tyr Asp Thr Glu Tyr Tyr Leu Ile Pro 
      290                          295                         300                 


Val Ala Ser Ser Ser Lys Asp Val Gln Leu Lys Asn Ile Thr Asp Tyr 
305                       310                         315                        320 


Met Tyr Leu Thr Asn Ala Pro Ser Tyr Thr Asn Gly Lys Leu Asn Ile 
                         325                         330                         335     


Tyr Tyr Arg Arg Leu Tyr Asn Gly Leu Lys Phe Ile Ile Lys Arg Tyr 
                 340                          345                      350         


Thr Pro Asn Asn Glu Ile Asp Ser Phe Val Lys Ser Gly Asp Phe Ile 
            355                         360                        365             


Lys Leu Tyr Val Ser Tyr Asn Asn Asn Glu His Ile Val Gly Tyr Pro 
      370                       375                          380                 


Lys Asp Gly Asn Ala Phe Asn Asn Leu Asp Arg Ile Leu Arg Val Gly 
385                         390                           395                        400 


Tyr Asn Ala Pro Gly Ile Pro Leu Tyr Lys Lys Met Glu Ala Val Lys 
                       405                        410                    415     


Leu Arg Asp Leu Lys Thr Tyr Ser Val Gln Leu Lys Leu Tyr Asp Asp 
            420                         425                         430         


Lys Asn Ala Ser Leu Gly Leu Val Gly Thr His Asn Gly Gln Ile Gly 
       435                        440                        445             


Asn Asp Pro Asn Arg Asp Ile Leu Ile Ala Ser Asn Trp Tyr Phe Asn 
      450                          455                       460                 


His Leu Lys Asp Lys Ile Leu Gly Cys Asp Trp Tyr Phe Val Pro Thr 
465                       470                         475                         480 


Asp Glu Gly Trp Thr Asn Asp 
                        485         


<210>  2
<211>  476
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  TTD-2

<400>  2

Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys Val Phe 
1                       5                          10                         15      


Ser Thr Pro Ile Pro Phe Ser Tyr Ser Lys Asn Leu Asp Cys Trp Val 
                  20                          25                           30          


Asp Asn Glu Glu Asp Ile Asp Val Ile Leu Lys Lys Ser Thr Ile Leu 
              35                          40                         45              


Asn Leu Asp Ile Asn Asn Asp Ile Ile Ser Asp Ile Ser Gly Phe Asn 
       50                            55                       60                  


Ser Ser Val Ile Thr Tyr Pro Asp Ala Gln Leu Val Pro Gly Ile Asn 
65                         70                           75                         80  


Gly Lys Ala Ile His Leu Val Asn Asn Glu Ser Ser Glu Val Ile Val 
                      85                            90                         95      


His Lys Ala Met Asp Ile Glu Tyr Asn Asp Met Phe Asn Asn Phe Thr 
                 100                         105                            110         


Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu 
           115                          120                        125             


Gln Tyr Gly Thr Asn Glu Tyr Ser Ile Ile Ser Ser Met Lys Lys His 
      130                        135                      140                 


Ser Leu Ser Ile Gly Ser Gly Trp Ser Val Ser Leu Lys Gly Asn Asn 
145                       150                       155                          160 


Leu Ile Trp Thr Leu Lys Asp Ser Ala Gly Glu Val Arg Gln Ile Thr 
                       165                        170                         175     


Phe Arg Asp Leu Pro Asp Lys Phe Asn Ala Tyr Leu Ala Asn Lys Trp 
                   180                           185                         190         


Val Phe Ile Thr Ile Thr Asn Asp Arg Leu Ser Ser Ala Asn Leu Tyr 
           195                        200                         205             


Ile Asn Gly Val Leu Met Gly Ser Ala Glu Ile Thr Gly Leu Gly Ala 
    210                          215                        220                 


Ile Arg Glu Asp Asn Asn Ile Thr Leu Lys Leu Asp Arg Cys Asn Asn 
225                         230                        235                           240 


Asn Asn Gln Tyr Val Ser Ile Asp Lys Phe Arg Ile Phe Cys Lys Ala 
                         245                       250                         255     


Leu Asn Pro Lys Glu Ile Glu Lys Leu Tyr Thr Ser Tyr Leu Ser Ile 
                   260                       265                        270         


Thr Phe Leu Arg Asp Phe Trp Gly Asn Pro Leu Arg Tyr Asp Thr Glu 
             275                          280                          285             


Tyr Tyr Leu Ile Pro Val Ala Ser Ser Ser Lys Asp Val Gln Leu Lys 
    290                        295                        300                 


Asn Ile Thr Asp Tyr Met Tyr Leu Thr Asn Ala Pro Ser Tyr Thr Asn 
305                        310                          315                        320 


Gly Lys Leu Asn Ile Tyr Tyr Arg Arg Leu Tyr Asn Gly Leu Lys Phe 
                       325                        330                          335     


Ile Ile Lys Arg Tyr Thr Pro Asn Asn Glu Ile Asp Ser Phe Val Lys 
               340                         345                         350         


Ser Gly Asp Phe Ile Lys Leu Tyr Val Ser Tyr Asn Asn Asn Glu His 
            355                       360                         365             


Ile Val Gly Tyr Pro Lys Asp Gly Asn Ala Phe Asn Asn Leu Asp Arg 
    370                        375                          380                 


Ile Leu Arg Val Gly Tyr Asn Ala Pro Gly Ile Pro Leu Tyr Lys Lys 
385                       390                        395                        400 


Met Glu Ala Val Lys Leu Arg Asp Leu Lys Thr Tyr Ser Val Gln Leu 
                         405                         410                        415     


Lys Leu Tyr Asp Asp Lys Asn Ala Ser Leu Gly Leu Val Gly Thr His 
                 420                          425                         430         


Asn Gly Gln Ile Gly Asn Asp Pro Asn Arg Asp Ile Leu Ile Ala Ser 
            435                        440                          445             


Asn Trp Tyr Phe Asn His Leu Lys Asp Lys Ile Leu Gly Cys Asp Trp 
      450                          455                       460                 


Tyr Phe Val Pro Thr Asp Glu Gly Trp Thr Asn Asp 
465                        470                           475     


<210>  3
<211>  451
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  TTD-3

<400>  3

Lys Asn Leu Asp Cys Trp Val Asp Asn Glu Glu Asp Ile Asp Val Ile 
1                         5                            10                           15      


Leu Lys Lys Ser Thr Ile Leu Asn Leu Asp Ile Asn Asn Asp Ile Ile 
                 20                           25                           30          


Ser Asp Ile Ser Gly Phe Asn Ser Ser Val Ile Thr Tyr Pro Asp Ala 
            35                           40                        45              


Gln Leu Val Pro Gly Ile Asn Gly Lys Ala Ile His Leu Val Asn Asn 
      50                          55                        60                  


Glu Ser Ser Glu Val Ile Val His Lys Ala Met Asp Ile Glu Tyr Asn 
65                          70                         75                          80  


Asp Met Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys 
                             85                           90                           95      


Val Ser Ala Ser His Leu Glu Gln Tyr Asp Thr Asn Glu Tyr Ser Ile 
                 100                         105                         110         


Ile Ser Ser Met Lys Lys Tyr Ser Leu Ser Ile Gly Ser Gly Trp Ser 
         115                         120                       125             


Val Ser Leu Lys Gly Asn Asn Leu Ile Trp Thr Leu Lys Asp Ser Ala 
     130                         135                         140                 


Gly Glu Val Arg Gln Ile Thr Phe Arg Asp Leu Ser Asp Lys Phe Asn 
145                        150                          155                          160 


Ala Tyr Leu Ala Asn Lys Trp Val Phe Ile Thr Ile Thr Asn Asp Arg 
                       165                         170                        175     


Leu Ser Ser Ala Asn Leu Tyr Ile Asn Gly Val Leu Met Gly Ser Ala 
                 180                        185                           190         


Glu Ile Thr Gly Leu Gly Ala Ile Arg Glu Asp Asn Asn Ile Thr Leu 
           195                       200                          205             


Lys Leu Asp Arg Cys Asn Asn Asn Asn Gln Tyr Val Ser Ile Asp Lys 
      210                          215                           220                 


Phe Arg Ile Phe Cys Lys Ala Leu Asn Pro Lys Glu Ile Glu Lys Leu 
225                         230                         235                        240 


Tyr Thr Ser Tyr Leu Ser Ile Thr Phe Leu Arg Asp Phe Trp Gly Asn 
                       245                        250                           255     


Pro Leu Arg Tyr Asp Thr Glu Tyr Tyr Leu Ile Pro Val Ala Tyr Ser 
                   260                        265                       270         


Ser Lys Asp Val Gln Leu Lys Asn Ile Thr Asp Tyr Met Tyr Leu Thr 
           275                          280                        285             


Asn Ala Pro Ser Tyr Thr Asn Gly Lys Leu Asn Ile Tyr Tyr Arg Arg 
      290                         295                        300                 


Leu Tyr Ser Gly Leu Lys Phe Ile Ile Lys Arg Tyr Thr Pro Asn Asn 
305                        310                       315                        320


Glu Ile Asp Ser Phe Val Arg Ser Gly Asp Phe Ile Lys Leu Tyr Val 
                        325                         330                        335     


Ser Tyr Asn Asn Asn Glu His Ile Val Gly Tyr Pro Lys Asp Gly Asn 
                 340                        345                        350         


Ala Phe Asn Asn Leu Asp Arg Ile Leu Arg Val Gly Tyr Asn Ala Pro 
            355                         360                         365             


Gly Ile Pro Leu Tyr Lys Lys Met Glu Ala Val Lys Leu Arg Asp Leu 
    370                        375                         380                 


Lys Thr Tyr Ser Val Gln Leu Lys Leu Tyr Asp Asp Lys Asp Ala Ser 
385                        390                        395                        400


Leu Gly Leu Val Gly Thr His Asn Gly Gln Ile Gly Asn Asp Pro Asn 
                         405                        410                         415     


Arg Asp Ile Leu Ile Ala Ser Asn Trp Tyr Phe Asn His Leu Lys Asp 
                 420                       425                          430         


Lys Thr Leu Thr Cys Asp Trp Tyr Phe Val Pro Thr Asp Glu Gly Trp 
            435                          440                        445             


Thr Asn Asp 
    450     


<210>  4
<211>  1458
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  TTD-4

<400>  4
cagtatataa aagcaaattc taaatttata ggtataactg aactaaaaaa attagaatca       60

aaaataaaca aagttttttc aacaccaatt ccattttctt attctaaaaa tctggattgt      120

tgggttgata atgaagaaga tatagatgtt atattaaaaa agagtacaat tttaaattta      180

gatattaata atgatattat atcagatata tctgggttta attcatctgt aataacatat      240

ccagatgctc aattggtgcc cggaataaat ggcaaagcaa tacatttagt aaacaatgaa      300

tcttctgaag ttatagtgca taaagctatg gatattgaat ataatgatat gtttaataat      360

tttaccgtta gcttttggtt gagggttcct aaagtatctg ctagtcattt agaacaatat      420

ggcacaaatg agtattcaat aattagctct atgaaaaaac atagtctatc aataggatct      480

ggttggagtg tatcacttaa aggtaataac ttaatatgga ctttaaaaga ttccgcggga      540

gaagttagac aaataacttt tagggattta cctgataaat ttaatgctta tttagcaaat      600

aaatgggttt ttataactat tactaatgat agattatctt ctgctaattt gtatataaat      660

ggagtactta tgggaagtgc agaaattact ggtttaggag ctattagaga ggataataat      720

ataacattaa aactagatag atgtaataat aataatcaat acgtttctat tgataaattt      780

aggatatttt gcaaagcatt aaatccaaaa gagattgaaa aattatacac aagttattta      840

tctataacct ttttaagaga cttctgggga aaccctttac gatatgatac agaatattat      900

ttaataccag tagcttctag ttctaaagat gttcaattga aaaatataac agattatatg      960

tatttgacaa atgcgccatc gtatactaac ggaaaattga atatatatta tagaaggtta     1020

tataatggac taaaatttat tataaaaaga tatacaccta ataatgaaat agattctttt     1080

gttaaatcag gtgattttat taaattatat gtatcatata acaataatga gcacattgta     1140

ggttatccga aagatggaaa tgcctttaat aatcttgata gaattctaag agtaggttat     1200

aatgccccag gtatccctct ttataaaaaa atggaagcag taaaattgcg tgatttaaaa     1260

acctattctg tacaacttaa attatatgat gataaaaatg catctttagg actagtaggt     1320

acccataatg gtcaaatagg caacgatcca aatagggata tattaattgc aagcaactgg     1380

tactttaatc atttaaaaga taaaatttta ggatgtgatt ggtactttgt acctacagat     1440

gaaggatgga caaatgat                                                   1458


<210>  5
<211>  1428
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>TTD-5

<400>  5
ggaattacag aattaaaaaa gctggagagt aagataaata aggtttttag cacgcctata       60

cctttctcgt atagtaaaaa ccttgactgc tgggtggata acgaagagga catcgacgtc      120

atattgaaaa aatcgactat tttaaattta gacattaaca atgacattat ttcggacatt      180

tcaggcttta actcatcagt aataacttat cctgacgcac aattggtccc tggaatcaac      240

ggtaaagcca tccatctggt gaacaacgaa agttccgaag tgattgtcca taaagctatg      300

gacattgagt ataacgatat gtttaataat ttcactgtga gtttttggct gcgtgtccct      360

aaagtatctg ccagtcactt agagcaatat ggtacgaacg aatactcgat aatttcatct      420

atgaaaaaac atagcttgtc aatcggctca ggctggtccg tctcactgaa gggcaataat      480

cttatctgga ccctgaagga ctctgcgggt gaagtacggc agatcacgtt tagagatctt      540

ccggataaat ttaacgctta tttagcgaac aaatgggtct ttatcactat cacaaatgat      600

cgtctgtcga gcgccaacct ttatattaac ggagtactga tgggtagtgc tgagattacc      660

ggacttggag cgattcggga agacaacaac atcaccctta aacttgatcg ttgtaacaat      720

aataatcagt acgtgagcat cgacaagttt cggatatttt gtaaggcgtt aaatccgaag      780

gaaattgaaa aattatatac atcgtatctg tcaatcactt tcttgcggga tttctggggg      840

aatcctcttc ggtatgatac cgaatactat cttatacctg tggcatctag tagtaaggat      900

gtacagttga agaacattac agattatatg tatcttacca atgcacccag ttacacaaac      960

ggcaagttaa atatctatta tcgccggctt tataacggtc tgaaattcat cataaaaaga     1020

tacactccca acaacgagat agattctttt gtcaagagcg gagacttcat taagttatat     1080

gtcagctaca acaacaatga gcacatagtt ggctacccaa aggacggaaa cgcgtttaac     1140

aacctggatc gtatactgcg ggtgggctat aacgcgcctg ggattccctt gtataaaaag     1200

atggaagcag taaaattgcg cgacttgaag acgtactccg tacaacttaa actttacgac     1260

gacaaaaatg cgagtcttgg attggttggt acgcacaacg gacagatcgg gaatgatccg     1320

aaccgtgaca tcttaattgc atcaaattgg tactttaatc atttgaaaga caaaatcctt     1380

ggctgcgatt ggtattttgt tccgactgat gaggggtgga cgaacgac                  1428


<210>  6
<211>  1353
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  TTD-6

<400>  6
aaaaaccttg actgctgggt ggataacgaa gaggacatcg acgtcatatt gaaaaaatcg       60

actattttaa atttagacat taacaatgac attatttcgg acatttcagg ctttaactca      120

tcagtaataa cttatcctga cgcacaattg gtccctggaa tcaacggtaa agccatccat      180

ctggtgaaca acgaaagttc cgaagtgatt gtccataaag ctatggacat tgagtataac      240

gatatgttta ataatttcac tgtgagtttt tggctgcgtg tccctaaagt atctgccagt      300

cacttagagc aatatggtac gaacgaatac tcgataattt catctatgaa aaaacatagc      360

ttgtcaatcg gctcaggctg gtccgtctca ctgaagggca ataatcttat ctggaccctg      420

aaggactctg cgggtgaagt acggcagatc acgtttagag atcttccgga taaatttaac      480

gcttatttag cgaacaaatg ggtctttatc actatcacaa atgatcgtct gtcgagcgcc      540

aacctttata ttaacggagt actgatgggt agtgctgaga ttaccggact tggagcgatt      600

cgggaagaca acaacatcac ccttaaactt gatcgttgta acaataataa tcagtacgtg      660

agcatcgaca agtttcggat attttgtaag gcgttaaatc cgaaggaaat tgaaaaatta      720

tatacatcgt atctgtcaat cactttcttg cgggatttct gggggaatcc tcttcggtat      780

gataccgaat actatcttat acctgtggca tctagtagta aggatgtaca gttgaagaac      840

attacagatt atatgtatct taccaatgca cccagttaca caaacggcaa gttaaatatc      900

tattatcgcc ggctttataa cggtctgaaa ttcatcataa aaagatacac tcccaacaac      960

gagatagatt cttttgtcaa gagcggagac ttcattaagt tatatgtcag ctacaacaac     1020

aatgagcaca tagttggcta cccaaaggac ggaaacgcgt ttaacaacct ggatcgtata     1080

ctgcgggtgg gctataacgc gcctgggatt cccttgtata aaaagatgga agcagtaaaa     1140

ttgcgcgact tgaagacgta ctccgtacaa cttaaacttt acgacgacaa aaatgcgagt     1200

cttggattgg ttggtacgca caacggacag atcgggaatg atccgaaccg tgacatctta     1260

attgcatcaa attggtactt taatcatttg aaagacaaaa tccttggctg cgattggtat     1320

tttgttccga ctgatgaggg gtggacgaac gac                                  1353


<210>  7
<211>  36
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  λİ07

<400>  7

Met Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu 
1               5                   10                  15      


Lys Lys Leu Glu Ser Lys Ile Asn Lys Val Phe Ser Thr Pro Ile Pro 
            20                  25                  30          


Phe Ser Tyr Ser 
        35      

<210>  8
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  λİ08

<400>  8

Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys Val Phe 
1               5                   10                  15      


Ser Thr Pro Ile Pro Phe Ser Tyr Ser 
            20                  25  
