                         SEQUENCE LISTING

<110>  The Board of Trustees of the Leland Stanford Junior
       University
 
<120>  Compositions and Methods for Inhibition of Natural Killer Cell 
       Receptors

<130>  078430-526001WO

<140>  Herewith
<141>  Herewith

<150>  US 63/092,273
<151>  2020-10-15

<160>  47    

<170>  PatentIn version 3.5

<210>  1
<211>  511
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<220>
<221>  MISC_FEATURE
<223>  NKG2A-RIPR Polypeptide

<220>
<221>  MISC_FEATURE
<222>  (1)..(118)
<223>  VH

<220>
<221>  MISC_FEATURE
<222>  (119)..(122)
<223>  linker

<220>
<221>  MISC_FEATURE
<222>  (123)..(229)
<223>  VL

<220>
<221>  MISC_FEATURE
<222>  (230)..(262)
<223>  linker

<220>
<221>  MISC_FEATURE
<222>  (263)..(387)
<223>  VH

<220>
<221>  MISC_FEATURE
<222>  (388)..(392)
<223>  linker

<220>
<221>  MISC_FEATURE
<222>  (393)..(399)
<223>  VL

<400>  1

Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ile Ile His Trp Val Lys Gln Glu Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Phe Asn Pro Tyr Asn His Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Pro Tyr Ala Trp Phe Asp Thr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
        115                 120                 125             


Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly Glu Thr Val Thr Ile 
    130                 135                 140                 


Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr Leu Ala Trp Tyr Gln 
145                 150                 155                 160 


Gln Lys Gln Gly Lys Ser Pro Gln Phe Leu Val Tyr Asn Ala Lys Thr 
                165                 170                 175     


Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
            180                 185                 190         


Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro Glu Asp Phe Gly Ser 
        195                 200                 205             


Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Arg Thr Phe Gly Gly Gly 
    210                 215                 220                 


Thr Lys Leu Glu Ile Lys Arg Arg Ala Asp Ala Ala Ala Ala Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Thr Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala 
            260                 265                 270         


Glu Leu Val Arg Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser 
        275                 280                 285             


Gly Tyr Thr Phe Thr Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro 
    290                 295                 300                 


Glu Gln Gly Leu Gln Trp Ile Gly Arg Ile Asp Pro Tyr Asp Ser Glu 
305                 310                 315                 320 


Thr His Tyr Ser Gln Lys Phe Lys Asp Lys Ala Ile Leu Thr Val Asp 
                325                 330                 335     


Lys Ser Ser Ser Thr Ala Tyr Met Arg Leu Ser Ser Leu Thr Ser Glu 
            340                 345                 350         


Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Gly Tyr Asp Phe Asp Val 
        355                 360                 365             


Gly Thr Leu Tyr Trp Phe Phe Asp Val Trp Gly Ala Gly Thr Thr Val 
    370                 375                 380                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Leu Leu Thr Gln Ser 
385                 390                 395                 400 


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
                405                 410                 415     


Arg Ala Ser Gln Asn Ile Gly Thr Ser Ile Gln Trp Tyr Gln Gln Lys 
            420                 425                 430         


Pro Gly Gln Ala Pro Arg Leu Leu Ile Arg Ser Ser Ser Glu Ser Ile 
        435                 440                 445             


Ser Gly Ile Ser Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
    450                 455                 460                 


Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr 
465                 470                 475                 480 


Cys Gln Gln Ser Asn Thr Trp Pro Phe Thr Phe Gly Gln Gly Thr Lys 
                485                 490                 495     


Leu Glu Ile Lys Ala Ala Ala His His His His His His His His 
            500                 505                 510     


<210>  2
<211>  511
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<220>
<221>  MISC_FEATURE
<223>  KIR2DL-RIPR Polypeptide

<220>
<221>  MISC_FEATURE
<222>  (1)..(118)
<223>  VH

<220>
<221>  MISC_FEATURE
<222>  (119)..(123)
<223>  linker

<220>
<221>  MISC_FEATURE
<222>  (124)..(232)
<223>  VL

<220>
<221>  MISC_FEATURE
<222>  (233)..(265)
<223>  linker

<220>
<221>  MISC_FEATURE
<222>  (266)..(388)
<223>  VH

<220>
<221>  MISC_FEATURE
<222>  (389)..(393)
<223>  linker

<220>
<221>  MISC_FEATURE
<222>  (394)..(500)
<223>  VL

<400>  2

Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ile Ile His Trp Val Lys Gln Glu Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Phe Asn Pro Tyr Asn His Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Pro Tyr Ala Trp Phe Asp Thr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr 
        115                 120                 125             


Gln Ser Pro Val Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
    130                 135                 140                 


Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln 
145                 150                 155                 160 


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn 
                165                 170                 175     


Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
            180                 185                 190         


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val 
        195                 200                 205             


Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Met Tyr Thr Phe Gly Gln Gly 
    210                 215                 220                 


Thr Lys Leu Glu Ile Lys Arg Thr Arg Arg Ala Asp Ala Ala Ala Ala 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Thr Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser 
            260                 265                 270         


Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys 
        275                 280                 285             


Ala Ser Gly Gly Thr Phe Ser Phe Tyr Ala Ile Ser Trp Val Arg Gln 
    290                 295                 300                 


Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Phe Ile Pro Ile Phe 
305                 310                 315                 320 


Gly Ala Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr 
                325                 330                 335     


Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg 
            340                 345                 350         


Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ile Pro Ser Gly Ser 
        355                 360                 365             


Tyr Tyr Tyr Asp Tyr Asp Met Asp Val Trp Gly Gln Gly Thr Thr Val 
    370                 375                 380                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Leu Leu Thr Gln Ser 
385                 390                 395                 400 


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
                405                 410                 415     


Arg Ala Ser Gln Asn Ile Gly Thr Ser Ile Gln Trp Tyr Gln Gln Lys 
            420                 425                 430         


Pro Gly Gln Ala Pro Arg Leu Leu Ile Arg Ser Ser Ser Glu Ser Ile 
        435                 440                 445             


Ser Gly Ile Ser Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
    450                 455                 460                 


Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr 
465                 470                 475                 480 


Cys Gln Gln Ser Asn Thr Trp Pro Phe Thr Phe Gly Gln Gly Thr Lys 
                485                 490                 495     


Leu Glu Ile Lys Ala Ala Ala His His His His His His His His 
            500                 505                 510     


<210>  3
<211>  261
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<220>
<221>  MISC_FEATURE
<223>  Anti-NKG2A scFv Polypeptide

<220>
<221>  MISC_FEATURE
<222>  (1)..(125)
<223>  VH

<220>
<221>  MISC_FEATURE
<222>  (126)..(143)
<223>  linker

<220>
<221>  MISC_FEATURE
<222>  (144)..(250)
<223>  VL

<400>  3

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Gln Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Ile Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Arg Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Asp Phe Asp Val Gly Thr Leu Tyr Trp Phe Phe 
            100                 105                 110         


Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Ser 
        115                 120                 125             


Thr Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Asp 
    130                 135                 140                 


Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly Glu 
145                 150                 155                 160 


Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Phe Leu Val Tyr 
            180                 185                 190         


Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Arg Thr 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala His His His 
                245                 250                 255     


His His His His His 
            260     


<210>  4
<211>  261
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<220>
<221>  MISC_FEATURE
<223>  Anti-KIR2DL scFv Polypeptide

<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH

<220>
<221>  MISC_FEATURE
<222>  (123)..(141)
<223>  linker

<220>
<221>  MISC_FEATURE
<222>  (142)..(250)
<223>  VL

<400>  4

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Ile Pro Ile Phe Gly Ala Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Pro Ser Gly Ser Tyr Tyr Tyr Asp Tyr Asp Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Ser Thr Arg 
        115                 120                 125             


Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Glu Ile Val 
    130                 135                 140                 


Leu Thr Gln Ser Pro Val Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
145                 150                 155                 160 


Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala 
            180                 185                 190         


Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Met Tyr Thr Phe Gly 
225                 230                 235                 240 


Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Ala Ala Ala His His His 
                245                 250                 255     


His His His His His 
            260     


<210>  5
<211>  1536
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<220>
<221>  misc_feature
<223>  Nucleotide sequence encoding the NKG2A-RIPR construct of SEQ ID 
       NO: 1

<400>  5
caagtgcagc tggtagaaag tggcgcggaa gtaaaaaagc ccggtgcctc tgtcaaagtt       60

tcttgcaaag ccagtggtta tacgtttacg aactacatca ttcactgggt taagcaggaa      120

cccggacaag gcctcgaatg gattggatat ttcaacccct acaaccacgg caccaagtat      180

aacgaaaaat tcaagggaag ggcgacgctg acagcggata aatccatctc taccgcgtat      240

atggaactga gctcattgag gagtgaagac actgcagtct actattgcgc tcgcagcggc      300

ccatacgcat ggtttgacac ttggggtcaa ggaactaccg ttaccgtcag ttccggtggc      360

ggaggaagcg atattcaaat gacacagtct cctgcctcac tcagtgcctc agtgggcgag      420

accgtaacga ttacttgcag ggcctccgaa aacatatatt cttatcttgc gtggtatcaa      480

cagaaacaag gtaaaagccc gcaatttttg gtttataatg caaagaccct tgctgaaggc      540

gtgccatcca ggttttctgg aagcggatct ggcacacagt ttagcctcaa gataaatagt      600

ctccaaccgg aggattttgg tagttattat tgccaacatc actatggcac acctcgtaca      660

tttggtggtg gcactaaact ggaaatcaaa cgccgcgcag acgctgccgc ggcaggagga      720

ggaggatcag gtggtggagg atctggagga ggaggtagcg gaggtggtgg aaccggcgga      780

ggaggttcac aagtacagct tcaacagcct ggagcggaat tggttcgccc aggagcaagc      840

gtcaagctgt cctgcaaagc aagtggttac acatttacta gttattggat gaattgggta      900

aaacagcgcc cagagcaagg acttcagtgg attggaagga tagatccgta tgacagtgaa      960

acacactaca gtcaaaagtt taaggataaa gcgatcttga cagttgataa gagcagcagc     1020

acagcatata tgcgcttgag ttccctgacc tctgaggata gtgccgtata ttattgcgca     1080

agaggcggtt acgacttcga cgtcggcacc ttgtactggt tctttgatgt ttggggtgct     1140

ggcactactg tgacagtatc ctcaggtgga ggaggcagcg atatcctgtt gacccaaagc     1200

cctgcaacgc ttagcttgtc tcccggtgag cgtgccacac tttcttgtag agcatcacag     1260

aacattggaa catctatcca atggtaccaa cagaagccgg gacaagcgcc ccgtcttctg     1320

atacgctcct caagcgagtc aattagcggc ataagtagca gattcagcgg atccggatcc     1380

ggcacggact ttacccttac tataagttcc ctcgagccgg aggatttcgc cgtctactat     1440

tgccagcaaa gcaatacttg gccgttcact ttcggtcaag gcactaaatt ggagattaag     1500

gcggccgcgc atcatcacca ccatcaccac cattaa                               1536


<210>  6
<211>  1536
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<220>
<221>  misc_feature
<223>  Nucleotide sequence encoding the KIR2DL-RIPR construct of SEQ ID 
       NO: 2

<400>  6
caagtacagc tcgtagagag tggcgcagaa gttaaaaagc ccggcgcatc tgttaaggtg       60

agctgtaaag ccagcggcta tacctttact aactatatca tccattgggt aaaacaagaa      120

ccgggccagg gattggagtg gattggatat tttaacccgt acaatcatgg tacgaagtac      180

aatgagaaat tcaagggacg tgcgactctc acagccgata agagcatatc aacggcatat      240

atggaactct ccagcttgac cagtgaagac accgcggttt actactgcgc taggtcagga      300

ccctacgcct ggtttgacac atggggtcaa ggtaccaccg tcaccgttag ctccggaggc      360

ggtggcagcg agatcgtttt gactcaatcc ccggtaactc tttcactgtc accaggtgag      420

agagctacat tgtcctgccg cgcatcccaa tcagttagtt cttatcttgc gtggtaccag      480

caaaagccgg gacaagctcc aagactcctt atatatgacg cgtccaacag ggcgacagga      540

ataccggcta gattttccgg ttctggtagt ggcactgact tcaccctgac catatcatcc      600

ctcgagcctg aggattttgc agtatattat tgccaacaaa ggtccaattg gatgtacaca      660

ttcggccaag gcactaaatt ggaaataaag cgcacgagac gtgccgacgc agcagccgcg      720

ggaggtggtg gctcaggcgg cggaggatct ggtggcggag gttctggagg cggcggtacc      780

ggtggcggtg gcagtcaggt tcaactggta cagagcggcg ccgaggtcaa gaagccggga      840

tcttcagtca aagtcagctg taaagctagc ggaggtactt tcagcttcta tgcaatatcc      900

tgggtaaggc aggcgcccgg acaaggcctg gagtggatgg gcggttttat ccccattttc      960

ggcgcggcca attatgctca gaagtttcaa ggtagggtta ctataaccgc tgacgaatca     1020

acatccacag cttatatgga actttcttct cttacctctg atgataccgc agtctactat     1080

tgcgcacgca taccgagtgg cagctactat tacgactacg atatggacgt ctggggccag     1140

ggtaccaccg ttacagttag ctctggcgga ggaggttctg acattctgct cacacagtct     1200

cctgcgacac tctcactttc ccccggagag cgcgctacac tgagctgccg tgcctctcag     1260

aatattggta cttctattca gtggtaccaa caaaaacctg gccaagcccc acgccttctt     1320

attcgctcca gctctgagag cataagtggc atttcctcac gcttttcagg atccggttcc     1380

ggaactgact tcactctcac catctcctcc ttggaacccg aagattttgc tgtttactat     1440

tgtcagcaaa gtaatacttg gccctttacg tttggtcaag gaaccaaact tgaaatcaag     1500

gcggccgcgc atcatcacca ccatcaccac cattaa                               1536


<210>  7
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<220>
<221>  MISC_FEATURE
<223>  Polypeptide linker

<400>  7

Gly Gly Ser Thr Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly 
        


<210>  8
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<220>
<221>  MISC_FEATURE
<223>  Polypeptide linker

<400>  8

Gly Gly Gly Gly Ser 
1               5   


<210>  9
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<223>  Polypeptide linker

<400>  9

Arg Arg Ala Asp Ala Ala Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Thr Gly Gly Gly Gly 
            20                  25                  30          


Ser 
    


<210>  10
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is either Isoleucine or Valine

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is either Serine or Threonine

<400>  10

Xaa His Cys Xaa Ala Gly Xaa Xaa Arg Xaa Gly 
1               5                   10      


<210>  11
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<220>
<221>  MISC_FEATURE
<222>  (1)..(25)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Bases 1-20 may be present or absent

<400>  11

Gly Gly Gly Xaa Xaa Gly Gly Gly Xaa Xaa Gly Gly Gly Xaa Xaa Gly 
1               5                   10                  15      


Gly Gly Xaa Xaa Gly Gly Gly Gly Ser 
            20                  25  


<210>  12
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<220>
<221>  MISC_FEATURE
<222>  (1)..(25)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Bases 6-25 may be present or absent

<400>  12

Gly Gly Gly Gly Ser Xaa Gly Gly Gly Ser Xaa Gly Gly Gly Ser Xaa 
1               5                   10                  15      


Gly Gly Gly Ser Xaa Gly Gly Gly Ser 
            20                  25  


<210>  13
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Bases 1-20 may be present or absent

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Proline

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Serine

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Proline

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Serine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Proline

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Serine

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Proline

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Serine

<400>  13

Gly Gly Gly Xaa Xaa Gly Gly Gly Xaa Xaa Gly Gly Gly Xaa Xaa Gly 
1               5                   10                  15      


Gly Gly Xaa Xaa Gly Gly Gly Gly Ser 
            20                  25  


<210>  14
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Bases 1-20 may be present or absent

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Glycine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Glutamine

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Glycine

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Glutamine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Glycine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Glutamine

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Glycine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Glutamine

<400>  14

Gly Gly Gly Xaa Xaa Gly Gly Gly Xaa Xaa Gly Gly Gly Xaa Xaa Gly 
1               5                   10                  15      


Gly Gly Xaa Xaa Gly Gly Gly Gly Ser 
            20                  25  


<210>  15
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Bases 1-20 may be present or absent

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Glycine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Alanine

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Glycine

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Alanine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Glycine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Alanine

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Glycine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Alanine

<400>  15

Gly Gly Gly Xaa Xaa Gly Gly Gly Xaa Xaa Gly Gly Gly Xaa Xaa Gly 
1               5                   10                  15      


Gly Gly Xaa Xaa Gly Gly Gly Gly Ser 
            20                  25  


<210>  16
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<220>
<221>  MISC_FEATURE
<222>  (1)..(25)
<223>  Xaa is Proline

<220>
<221>  MISC_FEATURE
<222>  (6)..(25)
<223>  Bases 6-25 may be present or absent

<400>  16

Gly Gly Gly Gly Ser Xaa Gly Gly Gly Ser Xaa Gly Gly Gly Ser Xaa 
1               5                   10                  15      


Gly Gly Gly Ser Xaa Gly Gly Gly Ser 
            20                  25  


<210>  17
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  17

Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  18
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  18

Gly Gly Gly Gly Gln Gly Gly Gly Gly Gln Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  19
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  19

Gly Gly Gly Pro Ser Gly Gly Gly Pro Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  20
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  20

Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Pro Gly Gly Gly Ser 
1               5                   10                  15  


<210>  21
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  21

Gly Ser Gly Gly Ser 
1               5   


<210>  22
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  22

Ser Gly Gly Ser Gly Ser 
1               5       


<210>  23
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  23

Gly Gly Gly Gly Ser 
1               5   


<210>  24
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  24

Ser Gly Gly Gly Gly 
1               5   


<210>  25
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  25

Gly Gly Gly Gly Gly Ser 
1               5       


<210>  26
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  26

Ser Gly Gly Gly Gly Gly 
1               5       


<210>  27
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  27

Gly Gly Gly Gly Gly Gly Ser 
1               5           


<210>  28
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  28

Ser Gly Gly Gly Gly Gly Gly 
1               5           


<210>  29
<211>  250
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<223>  Bases 1-250 may be present or absent

<400>  29

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                165                 170                 175     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            180                 185                 190         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        195                 200                 205             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    210                 215                 220                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250 


<210>  30
<211>  250
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<220>
<221>  MISC_FEATURE
<222>  (1)..(250)
<223>  Bases 1-250 may be present or absent

<400>  30

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        35                  40                  45              


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    50                  55                  60                  


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
65                  70                  75                  80  


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                85                  90                  95      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                165                 170                 175     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        195                 200                 205             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250 


<210>  31
<211>  255
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<220>
<221>  MISC_FEATURE
<223>  16A11-scFv Polypeptide

<220>
<221>  misc_feature
<222>  (1)..(112)
<223>  VL

<220>
<221>  misc_feature
<222>  (113)..(127)
<223>  linker

<220>
<221>  misc_feature
<222>  (128)..(244)
<223>  VH

<400>  31

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Tyr Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala Ser 
    130                 135                 140                 


Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Arg Phe Thr Ser Tyr Trp 
145                 150                 155                 160 


Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
                165                 170                 175     


Gly Ile Tyr Leu Gly Asn Ser Asp Thr Asn Tyr Asn Gln Lys Phe Lys 
            180                 185                 190         


Gly Lys Ala Lys Leu Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr Val 
        195                 200                 205             


Glu Val Ser Ser Leu Thr Ile Glu Asp Ser Ala Val Tyr Tyr Cys Ser 
    210                 215                 220                 


Arg Leu Asp Leu Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
225                 230                 235                 240 


Thr Val Ser Ser Ala Ala Ala His His His His His His His His 
                245                 250                 255 


<210>  32
<211>  382
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  MISC_FEATURE
<223>  16A11-RIPR Polypeptide

<220>
<221>  misc_feature
<222>  (1)..(119)
<223>  VHH

<220>
<221>  misc_feature
<222>  (120)..(127)
<223>  linker

<220>
<221>  misc_feature
<222>  (128)..(239)
<223>  VL

<220>
<221>  misc_feature
<222>  (240)..(254)
<223>  linker

<220>
<221>  misc_feature
<222>  (255)..(371)
<223>  VH

<400>  32

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val His Pro Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val Phe Asn Ser Ala 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ser Pro Gly Ser Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Val Val Gly Thr Pro Thr Tyr Ala Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ile Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Tyr 
                85                  90                  95      


Arg Ala Thr Tyr Thr Ser Gly Tyr Ser Arg Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Thr Gly Gly Ser Asp 
        115                 120                 125             


Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly Asp 
    130                 135                 140                 


Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser Asn 
145                 150                 155                 160 


Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
                165                 170                 175     


Lys Leu Leu Ile Tyr Lys Val Tyr Asn Arg Phe Ser Gly Val Pro Asp 
            180                 185                 190         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
        195                 200                 205             


Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser Thr 
    210                 215                 220                 


His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
                245                 250                 255     


Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala Ser Val 
            260                 265                 270         


Lys Met Ser Cys Lys Ala Ser Gly Tyr Arg Phe Thr Ser Tyr Trp Met 
        275                 280                 285             


His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Gly 
    290                 295                 300                 


Ile Tyr Leu Gly Asn Ser Asp Thr Asn Tyr Asn Gln Lys Phe Lys Gly 
305                 310                 315                 320 


Lys Ala Lys Leu Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr Val Glu 
                325                 330                 335     


Val Ser Ser Leu Thr Ile Glu Asp Ser Ala Val Tyr Tyr Cys Ser Arg 
            340                 345                 350         


Leu Asp Leu Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
        355                 360                 365             


Val Ser Ser Ala Ala Ala His His His His His His His His 
    370                 375                 380         


<210>  33
<211>  484
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  MISC_FEATURE
<223>  16A11-scFv-Fc Polypeptide

<220>
<221>  misc_feature
<222>  (1)..(112)
<223>  VL

<220>
<221>  misc_feature
<222>  (113)..(127)
<223>  linker

<220>
<221>  misc_feature
<222>  (128)..(244)
<223>  VH

<220>
<221>  misc_feature
<222>  (245)..(259)
<223>  linker

<220>
<221>  misc_feature
<222>  (260)..(473)
<223>  Fc

<400>  33

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Tyr Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala Ser 
    130                 135                 140                 


Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Arg Phe Thr Ser Tyr Trp 
145                 150                 155                 160 


Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
                165                 170                 175     


Gly Ile Tyr Leu Gly Asn Ser Asp Thr Asn Tyr Asn Gln Lys Phe Lys 
            180                 185                 190         


Gly Lys Ala Lys Leu Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr Val 
        195                 200                 205             


Glu Val Ser Ser Leu Thr Ile Glu Asp Ser Ala Val Tyr Tyr Cys Ser 
    210                 215                 220                 


Arg Leu Asp Leu Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
225                 230                 235                 240 


Thr Val Ser Ser Gly Ser Val Pro Arg Asp Cys Gly Cys Lys Pro Cys 
                245                 250                 255     


Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe 
    290                 295                 300                 


Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Phe Gln Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala 
            340                 345                 350         


Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg 
        355                 360                 365             


Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met 
    370                 375                 380                 


Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro 
385                 390                 395                 400 


Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn 
                405                 410                 415     


Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val 
            420                 425                 430         


Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr 
        435                 440                 445             


Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu 
    450                 455                 460                 


Lys Ser Leu Ser His Ser Pro Gly Lys Ala Ala Ala His His His His 
465                 470                 475                 480 


His His His His 
                


<210>  34
<211>  611
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  MISC_FEATURE
<223>  16A11-RIPR-Fc Polypeptide

<220>
<221>  misc_feature
<222>  (1)..(119)
<223>  VHH

<220>
<221>  misc_feature
<222>  (120)..(127)
<223>  linker

<220>
<221>  misc_feature
<222>  (128)..(239)
<223>  VL

<220>
<221>  misc_feature
<222>  (240)..(254)
<223>  linker

<220>
<221>  misc_feature
<222>  (255)..(371)
<223>  VH

<220>
<221>  misc_feature
<222>  (372)..(386)
<223>  linker

<220>
<221>  misc_feature
<222>  (387)..(600)
<223>  Fc

<400>  34

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val His Pro Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val Phe Asn Ser Ala 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ser Pro Gly Ser Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Val Val Gly Thr Pro Thr Tyr Ala Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ile Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Tyr 
                85                  90                  95      


Arg Ala Thr Tyr Thr Ser Gly Tyr Ser Arg Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Thr Gly Gly Ser Asp 
        115                 120                 125             


Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly Asp 
    130                 135                 140                 


Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser Asn 
145                 150                 155                 160 


Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
                165                 170                 175     


Lys Leu Leu Ile Tyr Lys Val Tyr Asn Arg Phe Ser Gly Val Pro Asp 
            180                 185                 190         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
        195                 200                 205             


Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser Thr 
    210                 215                 220                 


His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
                245                 250                 255     


Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala Ser Val 
            260                 265                 270         


Lys Met Ser Cys Lys Ala Ser Gly Tyr Arg Phe Thr Ser Tyr Trp Met 
        275                 280                 285             


His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Gly 
    290                 295                 300                 


Ile Tyr Leu Gly Asn Ser Asp Thr Asn Tyr Asn Gln Lys Phe Lys Gly 
305                 310                 315                 320 


Lys Ala Lys Leu Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr Val Glu 
                325                 330                 335     


Val Ser Ser Leu Thr Ile Glu Asp Ser Ala Val Tyr Tyr Cys Ser Arg 
            340                 345                 350         


Leu Asp Leu Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
        355                 360                 365             


Val Ser Ser Gly Ser Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile 
    370                 375                 380                 


Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro 
385                 390                 395                 400 


Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val 
                405                 410                 415     


Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val 
            420                 425                 430         


Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln 
        435                 440                 445             


Phe Gln Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln 
    450                 455                 460                 


Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala 
465                 470                 475                 480 


Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro 
                485                 490                 495     


Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala 
            500                 505                 510         


Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu 
        515                 520                 525             


Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr 
    530                 535                 540                 


Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr 
545                 550                 555                 560 


Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe 
                565                 570                 575     


Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys 
            580                 585                 590         


Ser Leu Ser His Ser Pro Gly Lys Ala Ala Ala His His His His His 
        595                 600                 605             


His His His 
    610     


<210>  35
<211>  252
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  MISC_FEATURE
<223>  20D5-scFv Polypeptide

<220>
<221>  misc_feature
<222>  (1)..(107)
<223>  VL

<220>
<221>  misc_feature
<222>  (108)..(122)
<223>  linker

<220>
<221>  misc_feature
<222>  (123)..(241)
<223>  VH

<400>  35

Asp Ile Val Met Ser Gln Ser Pro Thr Ser Met Ser Ile Ser Glu Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Asn Cys Lys Ala Ser Gln Ile Val Gly Ala Asn 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Lys Ile Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Lys Thr Phe Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Ser Ile Ser Asn Met Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Met Gln Ser His Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Glu Gln Leu Val Glu 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys 
    130                 135                 140                 


Val Ala Ser Gly Phe Thr Phe Asn Ser Phe Trp Met Thr Trp Ile Arg 
145                 150                 155                 160 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ser Ile Thr Asn Thr 
                165                 170                 175     


Gly Gly Arg Thr Tyr Tyr Pro Asp Ser Leu Arg Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Gly Lys Ser Thr Leu Tyr Leu Gln Met Ser Ser Leu 
        195                 200                 205             


Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Thr Arg Asp Leu Pro Gly 
    210                 215                 220                 


Tyr Asn Val Met Asp Ala Trp Gly Gln Gly Ala Ser Val Thr Val Ser 
225                 230                 235                 240 


Ser Ala Ala Ala His His His His His His His His 
                245                 250         


<210>  36
<211>  379
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  MISC_FEATURE
<223>  20D5-RIPR Polypeptide

<220>
<221>  misc_feature
<222>  (1)..(120)
<223>  VH

<220>
<221>  misc_feature
<222>  (121)..(127)
<223>  linker

<220>
<221>  misc_feature
<222>  (128)..(234)
<223>  VL

<220>
<221>  misc_feature
<222>  (235)..(249)
<223>  linker

<220>
<221>  misc_feature
<222>  (250)..(380)
<223>  VH

<400>  36

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val His Pro Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val Phe Asn Ser Ala 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ser Pro Gly Ser Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Val Val Gly Thr Pro Thr Tyr Ala Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ile Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Tyr 
                85                  90                  95      


Arg Ala Thr Tyr Thr Ser Gly Tyr Ser Arg Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Thr Gly Gly Ser Asp 
        115                 120                 125             


Ile Val Met Ser Gln Ser Pro Thr Ser Met Ser Ile Ser Glu Gly Asp 
    130                 135                 140                 


Arg Val Thr Met Asn Cys Lys Ala Ser Gln Ile Val Gly Ala Asn Val 
145                 150                 155                 160 


Asp Trp Tyr Gln Gln Lys Ile Gly Gln Ser Pro Lys Leu Leu Ile Phe 
                165                 170                 175     


Lys Thr Phe Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly Ser 
            180                 185                 190         


Gly Ser Gly Thr Asp Phe Thr Phe Ser Ile Ser Asn Met Gln Ala Glu 
        195                 200                 205             


Asp Leu Ala Val Tyr Tyr Cys Met Gln Ser His Ser Tyr Pro Tyr Thr 
    210                 215                 220                 


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Glu Gln Leu Val Glu Ser 
                245                 250                 255     


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Val 
            260                 265                 270         


Ala Ser Gly Phe Thr Phe Asn Ser Phe Trp Met Thr Trp Ile Arg Gln 
        275                 280                 285             


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ser Ile Thr Asn Thr Gly 
    290                 295                 300                 


Gly Arg Thr Tyr Tyr Pro Asp Ser Leu Arg Gly Arg Phe Thr Ile Ser 
305                 310                 315                 320 


Arg Asp Asn Gly Lys Ser Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg 
                325                 330                 335     


Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Thr Arg Asp Leu Pro Gly Tyr 
            340                 345                 350         


Asn Val Met Asp Ala Trp Gly Gln Gly Ala Ser Val Thr Val Ser Ser 
        355                 360                 365             


Ala Ala Ala His His His His His His His His 
    370                 375                 


<210>  37
<211>  481
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  MISC_FEATURE
<223>  20D5-scFv-Fc Polypeptide

<220>
<221>  misc_feature
<222>  (1)..(107)
<223>  VL

<220>
<221>  misc_feature
<222>  (108)..(122)
<223>  linker

<220>
<221>  misc_feature
<222>  (123)..(241)
<223>  VH

<220>
<221>  misc_feature
<222>  (242)..(256)
<223>  linker

<220>
<221>  misc_feature
<222>  (257)..(470)
<223>  Fc

<400>  37

Asp Ile Val Met Ser Gln Ser Pro Thr Ser Met Ser Ile Ser Glu Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Asn Cys Lys Ala Ser Gln Ile Val Gly Ala Asn 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Lys Ile Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Lys Thr Phe Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Ser Ile Ser Asn Met Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Met Gln Ser His Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Glu Gln Leu Val Glu 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys 
    130                 135                 140                 


Val Ala Ser Gly Phe Thr Phe Asn Ser Phe Trp Met Thr Trp Ile Arg 
145                 150                 155                 160 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ser Ile Thr Asn Thr 
                165                 170                 175     


Gly Gly Arg Thr Tyr Tyr Pro Asp Ser Leu Arg Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Gly Lys Ser Thr Leu Tyr Leu Gln Met Ser Ser Leu 
        195                 200                 205             


Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Thr Arg Asp Leu Pro Gly 
    210                 215                 220                 


Tyr Asn Val Met Asp Ala Trp Gly Gln Gly Ala Ser Val Thr Val Ser 
225                 230                 235                 240 


Ser Gly Ser Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr 
                245                 250                 255     


Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp 
    290                 295                 300                 


Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Gln 
305                 310                 315                 320 


Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala 
        355                 360                 365             


Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp 
    370                 375                 380                 


Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile 
385                 390                 395                 400 


Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn 
                405                 410                 415     


Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys 
            420                 425                 430         


Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys 
        435                 440                 445             


Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu 
    450                 455                 460                 


Ser His Ser Pro Gly Lys Ala Ala Ala His His His His His His His 
465                 470                 475                 480 


His 
    


<210>  38
<211>  608
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  MISC_FEATURE
<223>  20D5-RIPR-Fc Polypeptide

<220>
<221>  misc_feature
<222>  (1)..(119)
<223>  VH

<220>
<221>  misc_feature
<222>  (120)..(127)
<223>  linker

<220>
<221>  misc_feature
<222>  (128)..(234)
<223>  VL

<220>
<221>  misc_feature
<222>  (235)..(249)
<223>  linker

<220>
<221>  misc_feature
<222>  (250)..(368)
<223>  VH

<220>
<221>  misc_feature
<222>  (369)..(383)
<223>  linker

<220>
<221>  misc_feature
<222>  (384)..(597)
<223>  Fc

<400>  38

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val His Pro Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val Phe Asn Ser Ala 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ser Pro Gly Ser Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Val Val Gly Thr Pro Thr Tyr Ala Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ile Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Tyr 
                85                  90                  95      


Arg Ala Thr Tyr Thr Ser Gly Tyr Ser Arg Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Thr Gly Gly Ser Asp 
        115                 120                 125             


Ile Val Met Ser Gln Ser Pro Thr Ser Met Ser Ile Ser Glu Gly Asp 
    130                 135                 140                 


Arg Val Thr Met Asn Cys Lys Ala Ser Gln Ile Val Gly Ala Asn Val 
145                 150                 155                 160 


Asp Trp Tyr Gln Gln Lys Ile Gly Gln Ser Pro Lys Leu Leu Ile Phe 
                165                 170                 175     


Lys Thr Phe Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly Ser 
            180                 185                 190         


Gly Ser Gly Thr Asp Phe Thr Phe Ser Ile Ser Asn Met Gln Ala Glu 
        195                 200                 205             


Asp Leu Ala Val Tyr Tyr Cys Met Gln Ser His Ser Tyr Pro Tyr Thr 
    210                 215                 220                 


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Glu Gln Leu Val Glu Ser 
                245                 250                 255     


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Val 
            260                 265                 270         


Ala Ser Gly Phe Thr Phe Asn Ser Phe Trp Met Thr Trp Ile Arg Gln 
        275                 280                 285             


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ser Ile Thr Asn Thr Gly 
    290                 295                 300                 


Gly Arg Thr Tyr Tyr Pro Asp Ser Leu Arg Gly Arg Phe Thr Ile Ser 
305                 310                 315                 320 


Arg Asp Asn Gly Lys Ser Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg 
                325                 330                 335     


Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Thr Arg Asp Leu Pro Gly Tyr 
            340                 345                 350         


Asn Val Met Asp Ala Trp Gly Gln Gly Ala Ser Val Thr Val Ser Ser 
        355                 360                 365             


Gly Ser Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val 
    370                 375                 380                 


Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val 
385                 390                 395                 400 


Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile 
                405                 410                 415     


Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val 
            420                 425                 430         


Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Gln Ser 
        435                 440                 445             


Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu 
    450                 455                 460                 


Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala 
465                 470                 475                 480 


Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro 
                485                 490                 495     


Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys 
            500                 505                 510         


Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr 
        515                 520                 525             


Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr 
    530                 535                 540                 


Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu 
545                 550                 555                 560 


Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser 
                565                 570                 575     


Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser 
            580                 585                 590         


His Ser Pro Gly Lys Ala Ala Ala His His His His His His His His 
        595                 600                 605             


<210>  39
<211>  252
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  MISC_FEATURE
<223>  5E6-scFv Polypeptide

<220>
<221>  misc_feature
<222>  (1)..(111)
<223>  VL

<220>
<221>  misc_feature
<222>  (112)..(126)
<223>  linker

<220>
<221>  misc_feature
<222>  (127)..(242)
<223>  VH

<400>  39

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Ser Ala Ser Glu Ser Val Glu Tyr Tyr 
            20                  25                  30          


Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr His Phe Ser Leu Asp Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Asp Asp Val Ala Met Tyr Phe Cys Gln Gln Ser Arg 
                85                  90                  95      


Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val 
    130                 135                 140                 


Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Ile Asp Thr Tyr Met 
145                 150                 155                 160 


His Trp Val Lys Gln Arg Pro Gln Gln Gly Leu Glu Trp Ile Gly Arg 
                165                 170                 175     


Ile Asp Pro Ala Asn Gly Tyr Thr Lys Phe Asp Pro Lys Phe Gln Gly 
            180                 185                 190         


Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln 
        195                 200                 205             


Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg 
    210                 215                 220                 


Asp Gly Tyr Gly Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
225                 230                 235                 240 


Ala Ala Ala Ala His His His His His His His His 
                245                 250         


<210>  40
<211>  379
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  MISC_FEATURE
<223>  5E6-RIPR Polypeptide

<220>
<221>  misc_feature
<222>  (1)..(117)
<223>  VHH

<220>
<221>  misc_feature
<222>  (118)..(125)
<223>  linker

<220>
<221>  misc_feature
<222>  (126)..(238)
<223>  VL

<220>
<221>  misc_feature
<222>  (239)..(253)
<223>  linker

<220>
<221>  misc_feature
<222>  (254)..(369)
<223>  VH

<400>  40

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val His Pro Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val Phe Asn Ser Ala 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ser Pro Gly Ser Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Val Val Gly Thr Pro Thr Tyr Ala Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ile Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Tyr 
                85                  90                  95      


Arg Ala Thr Tyr Thr Ser Gly Tyr Ser Arg Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Thr Gly Gly Ser Asp 
        115                 120                 125             


Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln 
    130                 135                 140                 


Arg Ala Thr Ile Ser Cys Ser Ala Ser Glu Ser Val Glu Tyr Tyr Gly 
145                 150                 155                 160 


Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
                165                 170                 175     


Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala Arg 
            180                 185                 190         


Phe Ser Gly Ser Gly Ser Gly Thr His Phe Ser Leu Asp Ile His Pro 
        195                 200                 205             


Val Glu Glu Asp Asp Val Ala Met Tyr Phe Cys Gln Gln Ser Arg Lys 
    210                 215                 220                 


Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
                245                 250                 255     


Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys 
            260                 265                 270         


Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Ile Asp Thr Tyr Met His 
        275                 280                 285             


Trp Val Lys Gln Arg Pro Gln Gln Gly Leu Glu Trp Ile Gly Arg Ile 
    290                 295                 300                 


Asp Pro Ala Asn Gly Tyr Thr Lys Phe Asp Pro Lys Phe Gln Gly Lys 
305                 310                 315                 320 


Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu 
                325                 330                 335     


Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Asp 
            340                 345                 350         


Gly Tyr Gly Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        355                 360                 365             


Ala Ala Ala His His His His His His His His 
    370                 375                 


<210>  41
<211>  482
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  MISC_FEATURE
<223>  5E6-scFv-Fc Polypeptide

<220>
<221>  misc_feature
<222>  (1)..(112)
<223>  VL

<220>
<221>  misc_feature
<222>  (113)..(126)
<223>  linker

<220>
<221>  misc_feature
<222>  (127)..(222)
<223>  VH

<220>
<221>  misc_feature
<222>  (223)..(237)
<223>  linker

<220>
<221>  misc_feature
<222>  (238)..(451)
<223>  Fc

<400>  41

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Ser Ala Ser Glu Ser Val Glu Tyr Tyr 
            20                  25                  30          


Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr His Phe Ser Leu Asp Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Asp Asp Val Ala Met Tyr Phe Cys Gln Gln Ser Arg 
                85                  90                  95      


Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val 
    130                 135                 140                 


Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Ile Asp Thr Tyr Met 
145                 150                 155                 160 


His Trp Val Lys Gln Arg Pro Gln Gln Gly Leu Glu Trp Ile Gly Arg 
                165                 170                 175     


Ile Asp Pro Ala Asn Gly Tyr Thr Lys Phe Asp Pro Lys Phe Gln Gly 
            180                 185                 190         


Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln 
        195                 200                 205             


Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg 
    210                 215                 220                 


Asp Gly Tyr Gly Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
225                 230                 235                 240 


Ala Ala Gly Ser Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys 
                245                 250                 255     


Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp 
    290                 295                 300                 


Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe 
305                 310                 315                 320 


Gln Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys 
        355                 360                 365             


Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys 
    370                 375                 380                 


Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp 
385                 390                 395                 400 


Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys 
                405                 410                 415     


Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser 
            420                 425                 430         


Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr 
        435                 440                 445             


Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser 
    450                 455                 460                 


Leu Ser His Ser Pro Gly Lys Ala Ala Ala His His His His His His 
465                 470                 475                 480 


His His 
        


<210>  42
<211>  609
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  MISC_FEATURE
<223>  5E6-RIPR-Fc Polypeptide

<220>
<221>  misc_feature
<222>  (1)..(119)
<223>  VHH

<220>
<221>  misc_feature
<222>  (120)..(127)
<223>  linker

<220>
<221>  misc_feature
<222>  (128)..(238)
<223>  VL

<220>
<221>  misc_feature
<222>  (239)..(253)
<223>  linker

<220>
<221>  misc_feature
<222>  (254)..(369)
<223>  VH

<220>
<221>  misc_feature
<222>  (370)..(383)
<223>  linker

<220>
<221>  misc_feature
<222>  (384)..(598)
<223>  Fc

<400>  42

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val His Pro Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val Phe Asn Ser Ala 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ser Pro Gly Ser Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Val Val Gly Thr Pro Thr Tyr Ala Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ile Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Tyr 
                85                  90                  95      


Arg Ala Thr Tyr Thr Ser Gly Tyr Ser Arg Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Thr Gly Gly Ser Asp 
        115                 120                 125             


Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln 
    130                 135                 140                 


Arg Ala Thr Ile Ser Cys Ser Ala Ser Glu Ser Val Glu Tyr Tyr Gly 
145                 150                 155                 160 


Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
                165                 170                 175     


Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala Arg 
            180                 185                 190         


Phe Ser Gly Ser Gly Ser Gly Thr His Phe Ser Leu Asp Ile His Pro 
        195                 200                 205             


Val Glu Glu Asp Asp Val Ala Met Tyr Phe Cys Gln Gln Ser Arg Lys 
    210                 215                 220                 


Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
                245                 250                 255     


Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys 
            260                 265                 270         


Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Ile Asp Thr Tyr Met His 
        275                 280                 285             


Trp Val Lys Gln Arg Pro Gln Gln Gly Leu Glu Trp Ile Gly Arg Ile 
    290                 295                 300                 


Asp Pro Ala Asn Gly Tyr Thr Lys Phe Asp Pro Lys Phe Gln Gly Lys 
305                 310                 315                 320 


Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu 
                325                 330                 335     


Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Asp 
            340                 345                 350         


Gly Tyr Gly Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        355                 360                 365             


Ala Gly Ser Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr 
    370                 375                 380                 


Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
385                 390                 395                 400 


Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp 
                405                 410                 415     


Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp 
            420                 425                 430         


Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Gln 
        435                 440                 445             


Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp 
    450                 455                 460                 


Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro 
465                 470                 475                 480 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala 
                485                 490                 495     


Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp 
            500                 505                 510         


Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile 
        515                 520                 525             


Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn 
    530                 535                 540                 


Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys 
545                 550                 555                 560 


Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys 
                565                 570                 575     


Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu 
            580                 585                 590         


Ser His Ser Pro Gly Lys Ala Ala Ala His His His His His His His 
        595                 600                 605             


His 
    

<210>  43
<211>  258
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<220>
<221>  MISC_FEATURE
<223>  KIR3DL-scFv Polypeptide

<220>
<221>  misc_feature
<222>  (1)..(123)
<223>  VH

<220>
<221>  misc_feature
<222>  (124)..(141)
<223>  linker

<220>
<221>  misc_feature
<222>  (142)..(247)
<223>  VL

<400>  43

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Phe 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Asn Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Asn Ser Asn His Tyr Val Ser Ser Phe Tyr Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Ser Thr Arg 
        115                 120                 125             


Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly Gly Lys Val 
145                 150                 155                 160 


Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp 
                165                 170                 175     


Tyr Gln His Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile His Tyr Thr 
            180                 185                 190         


Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro Glu Asp Ile 
    210                 215                 220                 


Thr Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Trp Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala His His His His His His 
                245                 250                 255     


His His 
        


<210>  44
<211>  508
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<220>
<221>  MISC_FEATURE
<223>  KIR3DL-RIPR-Fc Polypeptide

<220>
<221>  misc_feature
<222>  (1)..(118)
<223>  VH

<220>
<221>  misc_feature
<222>  (119)..(123)
<223>  linker

<220>
<221>  misc_feature
<222>  (124)..(229)
<223>  VL

<220>
<221>  misc_feature
<222>  (230)..(262)
<223>  linker

<220>
<221>  misc_feature
<222>  (263)..(385)
<223>  VH

<220>
<221>  misc_feature
<222>  (386)..(390)
<223>  linker

<220>
<221>  misc_feature
<222>  (391)..(497)
<223>  VL


<400>  44

Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ile Ile His Trp Val Lys Gln Glu Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Phe Asn Pro Tyr Asn His Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Pro Tyr Ala Trp Phe Asp Thr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
        115                 120                 125             


Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly Gly Lys Val Thr Ile 
    130                 135                 140                 


Thr Cys Lys Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln 
145                 150                 155                 160 


His Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile His Tyr Thr Ser Thr 
                165                 170                 175     


Leu Gln Pro Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg 
            180                 185                 190         


Asp Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro Glu Asp Ile Thr Thr 
        195                 200                 205             


Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Trp Thr Phe Gly Gly Gly Thr 
    210                 215                 220                 


Lys Leu Glu Ile Lys Arg Arg Ala Asp Ala Ala Ala Ala Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Thr Gly Gly Gly Gly Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly 
            260                 265                 270         


Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly 
        275                 280                 285             


Phe Ser Leu Thr Ser Phe Gly Val His Trp Val Arg Gln Pro Pro Gly 
    290                 295                 300                 


Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ala Gly Gly Ser Thr Asn 
305                 310                 315                 320 


Tyr Asn Ser Ala Leu Met Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser 
                325                 330                 335     


Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Asn Asp Asp Thr 
            340                 345                 350         


Ala Met Tyr Tyr Cys Ala Arg Gly Asn Ser Asn His Tyr Val Ser Ser 
        355                 360                 365             


Phe Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Ile Leu Leu Thr Gln Ser Pro Ala Thr 
385                 390                 395                 400 


Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser 
                405                 410                 415     


Gln Asn Ile Gly Thr Ser Ile Gln Trp Tyr Gln Gln Lys Pro Gly Gln 
            420                 425                 430         


Ala Pro Arg Leu Leu Ile Arg Ser Ser Ser Glu Ser Ile Ser Gly Ile 
        435                 440                 445             


Ser Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    450                 455                 460                 


Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
465                 470                 475                 480 


Ser Asn Thr Trp Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
                485                 490                 495     


Lys Ala Ala Ala His His His His His His His His 
            500                 505             


<210>  45
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<220>
<221>  MISC_FEATURE
<223>  Polypeptide linker

<400>  45

Gly Ser Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr 
1               5                   10                  15  

<210>  46
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<223>  Polypeptide linker

<400>  46

Gly Gly Gly Ser 
1               


<210>  47
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<223>  Polypeptide linker

<400>  47

Ser Gly Gly Gly 
1               