                               SEQUENCE LISTING

<110> THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
 
<120> SYSTEMS FOR AND METHODS OF TREATMENT SELECTION

<130> 37944.0021P1

<140> PCT/US2021/055100
<141> 2021-10-14

<150> 63/091,924
<151> 2020-10-14

<160> 16    

<170> PatentIn version 3.5

<210> 1
<211> 393
<212> PRT
<213> Homo sapiens

<400> 1
Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu 
                325                 330                 335     


Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp 
            340                 345                 350         


Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His 
        355                 360                 365             


Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met 
    370                 375                 380                 


Phe Lys Thr Glu Gly Pro Asp Ser Asp 
385                 390             


<210> 2
<211> 173
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      PIK3CA sequence

<400> 2
Met Gln Pro Phe Ser Ile Pro Val Gln Ile Thr Leu Gln Gly Ser Arg 
1               5                   10                  15      


Arg Arg Gln Gly Arg Thr Ala Phe Pro Ala Ser Gly Lys Lys Arg Glu 
            20                  25                  30          


Thr Asp Tyr Ser Asp Gly Asp Pro Leu Asp Val His Lys Arg Leu Pro 
        35                  40                  45              


Ser Ser Ala Gly Glu Asp Arg Ala Val Met Leu Gly Phe Ala Met Met 
    50                  55                  60                  


Gly Phe Ser Val Leu Met Phe Phe Leu Leu Gly Thr Thr Ile Leu Lys 
65                  70                  75                  80  


Pro Phe Met Leu Ser Ile Gln Arg Glu Glu Ser Thr Cys Thr Ala Ile 
                85                  90                  95      


His Thr Asp Ile Met Asp Asp Trp Leu Asp Cys Ala Phe Thr Cys Gly 
            100                 105                 110         


Val His Cys His Gly Gln Gly Lys Tyr Pro Cys Leu Gln Val Phe Val 
        115                 120                 125             


Asn Leu Ser His Pro Gly Gln Lys Ala Leu Leu His Tyr Asn Glu Glu 
    130                 135                 140                 


Ala Val Gln Ile Asn Pro Lys Arg Asp Val Thr Asp Cys Arg Val Lys 
145                 150                 155                 160 


Glu Lys Gln Thr Leu Thr Val Ser Asp Glu His Lys Gln 
                165                 170             


<210> 3
<211> 1068
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      PIK3CA sequence

<400> 3
Met Pro Pro Arg Pro Ser Ser Gly Glu Leu Trp Gly Ile His Leu Met 
1               5                   10                  15      


Pro Pro Arg Ile Leu Val Glu Cys Leu Leu Pro Asn Gly Met Ile Val 
            20                  25                  30          


Thr Leu Glu Cys Leu Arg Glu Ala Thr Leu Ile Thr Ile Lys His Glu 
        35                  40                  45              


Leu Phe Lys Glu Ala Arg Lys Tyr Pro Leu His Gln Leu Leu Gln Asp 
    50                  55                  60                  


Glu Ser Ser Tyr Ile Phe Val Ser Val Thr Gln Glu Ala Glu Arg Glu 
65                  70                  75                  80  


Glu Phe Phe Asp Glu Thr Arg Arg Leu Cys Asp Leu Arg Leu Phe Gln 
                85                  90                  95      


Pro Phe Leu Lys Val Ile Glu Pro Val Gly Asn Arg Glu Glu Lys Ile 
            100                 105                 110         


Leu Asn Arg Glu Ile Gly Phe Ala Ile Gly Met Pro Val Cys Glu Phe 
        115                 120                 125             


Asp Met Val Lys Asp Pro Glu Val Gln Asp Phe Arg Arg Asn Ile Leu 
    130                 135                 140                 


Asn Val Cys Lys Glu Ala Val Asp Leu Arg Asp Leu Asn Ser Pro His 
145                 150                 155                 160 


Ser Arg Ala Met Tyr Val Tyr Pro Pro Asn Val Glu Ser Ser Pro Glu 
                165                 170                 175     


Leu Pro Lys His Ile Tyr Asn Lys Leu Asp Lys Gly Gln Ile Ile Val 
            180                 185                 190         


Val Ile Trp Val Ile Val Ser Pro Asn Asn Asp Lys Gln Lys Tyr Thr 
        195                 200                 205             


Leu Lys Ile Asn His Asp Cys Val Pro Glu Gln Val Ile Ala Glu Ala 
    210                 215                 220                 


Ile Arg Lys Lys Thr Arg Ser Met Leu Leu Ser Ser Glu Gln Leu Lys 
225                 230                 235                 240 


Leu Cys Val Leu Glu Tyr Gln Gly Lys Tyr Ile Leu Lys Val Cys Gly 
                245                 250                 255     


Cys Asp Glu Tyr Phe Leu Glu Lys Tyr Pro Leu Ser Gln Tyr Lys Tyr 
            260                 265                 270         


Ile Arg Ser Cys Ile Met Leu Gly Arg Met Pro Asn Leu Met Leu Met 
        275                 280                 285             


Ala Lys Glu Ser Leu Tyr Ser Gln Leu Pro Met Asp Cys Phe Thr Met 
    290                 295                 300                 


Pro Ser Tyr Ser Arg Arg Ile Ser Thr Ala Thr Pro Tyr Met Asn Gly 
305                 310                 315                 320 


Glu Thr Ser Thr Lys Ser Leu Trp Val Ile Asn Ser Ala Leu Arg Ile 
                325                 330                 335     


Lys Ile Leu Cys Ala Thr Tyr Val Asn Val Asn Ile Arg Asp Ile Asp 
            340                 345                 350         


Lys Ile Tyr Val Arg Thr Gly Ile Tyr His Gly Gly Glu Pro Leu Cys 
        355                 360                 365             


Asp Asn Val Asn Thr Gln Arg Val Pro Cys Ser Asn Pro Arg Trp Asn 
    370                 375                 380                 


Glu Trp Leu Asn Tyr Asp Ile Tyr Ile Pro Asp Leu Pro Arg Ala Ala 
385                 390                 395                 400 


Arg Leu Cys Leu Ser Ile Cys Ser Val Lys Gly Arg Lys Gly Ala Lys 
                405                 410                 415     


Glu Glu His Cys Pro Leu Ala Trp Gly Asn Ile Asn Leu Phe Asp Tyr 
            420                 425                 430         


Thr Asp Thr Leu Val Ser Gly Lys Met Ala Leu Asn Leu Trp Pro Val 
        435                 440                 445             


Pro His Gly Leu Glu Asp Leu Leu Asn Pro Ile Gly Val Thr Gly Ser 
    450                 455                 460                 


Asn Pro Asn Lys Glu Thr Pro Cys Leu Glu Leu Glu Phe Asp Trp Phe 
465                 470                 475                 480 


Ser Ser Val Val Lys Phe Pro Asp Met Ser Val Ile Glu Glu His Ala 
                485                 490                 495     


Asn Trp Ser Val Ser Arg Glu Ala Gly Phe Ser Tyr Ser His Ala Gly 
            500                 505                 510         


Leu Ser Asn Arg Leu Ala Arg Asp Asn Glu Leu Arg Glu Asn Asp Lys 
        515                 520                 525             


Glu Gln Leu Lys Ala Ile Ser Thr Arg Asp Pro Leu Ser Glu Ile Thr 
    530                 535                 540                 


Glu Gln Glu Lys Asp Phe Leu Trp Ser His Arg His Tyr Cys Val Thr 
545                 550                 555                 560 


Ile Pro Glu Ile Leu Pro Lys Leu Leu Leu Ser Val Lys Trp Asn Ser 
                565                 570                 575     


Arg Asp Glu Val Ala Gln Met Tyr Cys Leu Val Lys Asp Trp Pro Pro 
            580                 585                 590         


Ile Lys Pro Glu Gln Ala Met Glu Leu Leu Asp Cys Asn Tyr Pro Asp 
        595                 600                 605             


Pro Met Val Arg Gly Phe Ala Val Arg Cys Leu Glu Lys Tyr Leu Thr 
    610                 615                 620                 


Asp Asp Lys Leu Ser Gln Tyr Leu Ile Gln Leu Val Gln Val Leu Lys 
625                 630                 635                 640 


Tyr Glu Gln Tyr Leu Asp Asn Leu Leu Val Arg Phe Leu Leu Lys Lys 
                645                 650                 655     


Ala Leu Thr Asn Gln Arg Ile Gly His Phe Phe Phe Trp His Leu Lys 
            660                 665                 670         


Ser Glu Met His Asn Lys Thr Val Ser Gln Arg Phe Gly Leu Leu Leu 
        675                 680                 685             


Glu Ser Tyr Cys Arg Ala Cys Gly Met Tyr Leu Lys His Leu Asn Arg 
    690                 695                 700                 


Gln Val Glu Ala Met Glu Lys Leu Ile Asn Leu Thr Asp Ile Leu Lys 
705                 710                 715                 720 


Gln Glu Lys Lys Asp Glu Thr Gln Lys Val Gln Met Lys Phe Leu Val 
                725                 730                 735     


Glu Gln Met Arg Arg Pro Asp Phe Met Asp Ala Leu Gln Gly Phe Leu 
            740                 745                 750         


Ser Pro Leu Asn Pro Ala His Gln Leu Gly Asn Leu Arg Leu Glu Glu 
        755                 760                 765             


Cys Arg Ile Met Ser Ser Ala Lys Arg Pro Leu Trp Leu Asn Trp Glu 
    770                 775                 780                 


Asn Pro Asp Ile Met Ser Glu Leu Leu Phe Gln Asn Asn Glu Ile Ile 
785                 790                 795                 800 


Phe Lys Asn Gly Asp Asp Leu Arg Gln Asp Met Leu Thr Leu Gln Ile 
                805                 810                 815     


Ile Arg Ile Met Glu Asn Ile Trp Gln Asn Gln Gly Leu Asp Leu Arg 
            820                 825                 830         


Met Leu Pro Tyr Gly Cys Leu Ser Ile Gly Asp Cys Val Gly Leu Ile 
        835                 840                 845             


Glu Val Val Arg Asn Ser His Thr Ile Met Gln Ile Gln Cys Lys Gly 
    850                 855                 860                 


Gly Leu Lys Gly Ala Leu Gln Phe Asn Ser His Thr Leu His Gln Trp 
865                 870                 875                 880 


Leu Lys Asp Lys Asn Lys Gly Glu Ile Tyr Asp Ala Ala Ile Asp Leu 
                885                 890                 895     


Phe Thr Arg Ser Cys Ala Gly Tyr Cys Val Ala Thr Phe Ile Leu Gly 
            900                 905                 910         


Ile Gly Asp Arg His Asn Ser Asn Ile Met Val Lys Asp Asp Gly Gln 
        915                 920                 925             


Leu Phe His Ile Asp Phe Gly His Phe Leu Asp His Lys Lys Lys Lys 
    930                 935                 940                 


Phe Gly Tyr Lys Arg Glu Arg Val Pro Phe Val Leu Thr Gln Asp Phe 
945                 950                 955                 960 


Leu Ile Val Ile Ser Lys Gly Ala Gln Glu Cys Thr Lys Thr Arg Glu 
                965                 970                 975     


Phe Glu Arg Phe Gln Glu Met Cys Tyr Lys Ala Tyr Leu Ala Ile Arg 
            980                 985                 990         


Gln His Ala Asn Leu Phe Ile Asn  Leu Phe Ser Met Met  Leu Gly Ser 
        995                 1000                 1005             


Gly Met  Pro Glu Leu Gln Ser  Phe Asp Asp Ile Ala  Tyr Ile Arg 
    1010                 1015                 1020             


Lys Thr  Leu Ala Leu Asp Lys  Thr Glu Gln Glu Ala  Leu Glu Tyr 
    1025                 1030                 1035             


Phe Met  Lys Gln Met Asn Asp  Ala His His Gly Gly  Trp Thr Thr 
    1040                 1045                 1050             


Lys Met  Asp Trp Ile Phe His  Thr Ile Lys Gln His  Ala Leu Asn 
    1055                 1060                 1065             


<210> 4
<211> 3008
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown:
      Akt1 sequence

<400> 4
taattatggg tctgtaacca ccctggactg ggtgctcctc actgacggac ttgtctgaac       60

ctctctttgt ctccagcgcc cagcactggg cctggcaaaa cctgagacgc ccggtacatg      120

ttggccaaat gaatgaacca gattcagacc ggcaggggcg ctgtggttta ggaggggcct      180

ggggtttctc ccaggaggtt tttgggcttg cgctggaggg ctctggactc ccgtttgcgc      240

cagtggcctg catcctggtc ctgtcttcct catgtttgaa tttctttgct ttcctagtct      300

ggggagcagg gaggagccct gtgccctgtc ccaggatcca tgggtaggaa caccatggac      360

agggagagca aacggggcca tctgtcacca ggggcttagg gaaggccgag ccagcctggg      420

tcaaagaagt caaaggggct gcctggagga ggcagcctgt cagctggtgc atcagaggct      480

gtggccaggc cagctgggct cggggagcgc cagcctgaga ggagcgcgtg agcgtcgcgg      540

gagcctcggg caccatgagc gacgtggcta ttgtgaagga gggttggctg cacaaacgag      600

gggagtacat caagacctgg cggccacgct acttcctcct caagaatgat ggcaccttca      660

ttggctacaa ggagcggccg caggatgtgg accaacgtga ggctcccctc aacaacttct      720

ctgtggcgca gtgccagctg atgaagacgg agcggccccg gcccaacacc ttcatcatcc      780

gctgcctgca gtggaccact gtcatcgaac gcaccttcca tgtggagact cctgaggagc      840

gggaggagtg gacaaccgcc atccagactg tggctgacgg cctcaagaag caggaggagg      900

aggagatgga cttccggtcg ggctcaccca gtgacaactc aggggctgaa gagatggagg      960

tgtccctggc caagcccaag caccgcgtga ccatgaacga gtttgagtac ctgaagctgc     1020

tgggcaaggg cactttcggc aaggtgatcc tggtgaagga gaaggccaca ggccgctact     1080

acgccatgaa gatcctcaag aaggaagtca tcgtggccaa ggacgaggtg gcccacacac     1140

tcaccgagaa ccgcgtcctg cagaactcca ggcacccctt cctcacagcc ctgaagtact     1200

ctttccagac ccacgaccgc ctctgctttg tcatggagta cgccaacggg ggcgagctgt     1260

tcttccacct gtcccgggag cgtgtgttct ccgaggaccg ggcccgcttc tatggcgctg     1320

agattgtgtc agccctggac tacctgcact cggagaagaa cgtggtgtac cgggacctca     1380

agctggagaa cctcatgctg gacaaggacg ggcacattaa gatcacagac ttcgggctgt     1440

gcaaggaggg gatcaaggac ggtgccacca tgaagacctt ttgcggcaca cctgagtacc     1500

tggcccccga ggtgctggag gacaatgact acggccgtgc agtggactgg tgggggctgg     1560

gcgtggtcat gtacgagatg atgtgcggtc gcctgccctt ctacaaccag gaccatgaga     1620

agctttttga gctcatcctc atggaggaga tccgcttccc gcgcacgctt ggtcccgagg     1680

ccaagtcctt gctttcaggg ctgctcaaga aggaccccaa gcagaggctt ggcgggggct     1740

ccgaggacgc caaggagatc atgcagcatc gcttctttgc cggtatcgtg tggcagcacg     1800

tgtacgagaa gaagctcagc ccacccttca agccccaggt cacgtcggag actgacacca     1860

ggtattttga tgaggagttc acggcccaga tgatcaccat cacaccacct gaccaagatg     1920

acagcatgga gtgtgtggac agcgagcgca ggccccactt cccccagttc tcctactcgg     1980

ccagcggcac ggcctgaggc ggcggtggac tgcgctggac gatagcttgg agggatggag     2040

aggcggcctc gtgccatgat ctgtatttaa tggtttttat ttctcgggtg catttgagag     2100

aagccacgct gtcctctcga gcccagatgg aaagacgttt ttgtgctgtg ggcagcaccc     2160

tcccccgcag cggggtaggg aagaaaacta tcctgcgggt tttaatttat ttcatccagt     2220

ttgttctccg ggtgtggcct cagccctcag aacaatccga ttcacgtagg gaaatgttaa     2280

ggacttctgc agctatgcgc aatgtggcat tggggggccg ggcaggtcct gcccatgtgt     2340

cccctcactc tgtcagccag ccgccctggg ctgtctgtca ccagctatct gtcatctctc     2400

tggggccctg ggcctcagtt caacctggtg gcaccagatg caacctcact atggtatgct     2460

ggccagcacc ctctcctggg ggtggcaggc acacagcagc cccccagcac taaggccgtg     2520

tctctgagga cgtcatcgga ggctgggccc ctgggatggg accagggatg ggggatgggc     2580

cagggtttac ccagtgggac agaggagcaa ggtttaaatt tgttattgtg tattatgttg     2640

ttcaaatgca ttttgggggt ttttaatctt tgtgacagga aagccctccc ccttcccctt     2700

ctgtgtcaca gttcttggtg actgtcccac cgggagcctc cccctcagat gatctctcca     2760

cggtagcact tgaccttttc gacgcttaac ctttccgctg tcgccccagg ccctccctga     2820

ctccctgtgg gggtggccat ccctgggccc ctccacgcct cctggccaga cgctgccgct     2880

gccgctgcac cacggcgttt ttttacaaca ttcaacttta gtatttttac tattataata     2940

taatatggaa ccttccctcc aaattcttca ataaaagttg cttttcaaaa aaaaaaaaaa     3000

aaaaaaaa                                                              3008


<210> 5
<211> 1342
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      HER3 sequence

<400> 5
Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 
        35                  40                  45              


Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
            100                 105                 110         


Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 
        115                 120                 125             


His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser 
    130                 135                 140                 


Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr 
145                 150                 155                 160 


Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val 
                165                 170                 175     


Lys Asp Asn Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly 
            180                 185                 190         


Arg Cys Trp Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr 
        195                 200                 205             


Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn 
    210                 215                 220                 


Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp 
225                 230                 235                 240 


Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val 
                245                 250                 255     


Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu 
            260                 265                 270         


Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala 
        275                 280                 285             


Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala 
    290                 295                 300                 


Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys 
305                 310                 315                 320 


Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ser 
                325                 330                 335     


Gly Ser Arg Phe Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val 
            340                 345                 350         


Asn Cys Thr Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu 
        355                 360                 365             


Asn Gly Asp Pro Trp His Lys Ile Pro Ala Leu Asp Pro Glu Lys Leu 
    370                 375                 380                 


Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln 
385                 390                 395                 400 


Ser Trp Pro Pro His Met His Asn Phe Ser Val Phe Ser Asn Leu Thr 
                405                 410                 415     


Thr Ile Gly Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile 
            420                 425                 430         


Met Lys Asn Leu Asn Val Thr Ser Leu Gly Phe Arg Ser Leu Lys Glu 
        435                 440                 445             


Ile Ser Ala Gly Arg Ile Tyr Ile Ser Ala Asn Arg Gln Leu Cys Tyr 
    450                 455                 460                 


His His Ser Leu Asn Trp Thr Lys Val Leu Arg Gly Pro Thr Glu Glu 
465                 470                 475                 480 


Arg Leu Asp Ile Lys His Asn Arg Pro Arg Arg Asp Cys Val Ala Glu 
                485                 490                 495     


Gly Lys Val Cys Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly Pro 
            500                 505                 510         


Gly Pro Gly Gln Cys Leu Ser Cys Arg Asn Tyr Ser Arg Gly Gly Val 
        515                 520                 525             


Cys Val Thr His Cys Asn Phe Leu Asn Gly Glu Pro Arg Glu Phe Ala 
    530                 535                 540                 


His Glu Ala Glu Cys Phe Ser Cys His Pro Glu Cys Gln Pro Met Glu 
545                 550                 555                 560 


Gly Thr Ala Thr Cys Asn Gly Ser Gly Ser Asp Thr Cys Ala Gln Cys 
                565                 570                 575     


Ala His Phe Arg Asp Gly Pro His Cys Val Ser Ser Cys Pro His Gly 
            580                 585                 590         


Val Leu Gly Ala Lys Gly Pro Ile Tyr Lys Tyr Pro Asp Val Gln Asn 
        595                 600                 605             


Glu Cys Arg Pro Cys His Glu Asn Cys Thr Gln Gly Cys Lys Gly Pro 
    610                 615                 620                 


Glu Leu Gln Asp Cys Leu Gly Gln Thr Leu Val Leu Ile Gly Lys Thr 
625                 630                 635                 640 


His Leu Thr Met Ala Leu Thr Val Ile Ala Gly Leu Val Val Ile Phe 
                645                 650                 655     


Met Met Leu Gly Gly Thr Phe Leu Tyr Trp Arg Gly Arg Arg Ile Gln 
            660                 665                 670         


Asn Lys Arg Ala Met Arg Arg Tyr Leu Glu Arg Gly Glu Ser Ile Glu 
        675                 680                 685             


Pro Leu Asp Pro Ser Glu Lys Ala Asn Lys Val Leu Ala Arg Ile Phe 
    690                 695                 700                 


Lys Glu Thr Glu Leu Arg Lys Leu Lys Val Leu Gly Ser Gly Val Phe 
705                 710                 715                 720 


Gly Thr Val His Lys Gly Val Trp Ile Pro Glu Gly Glu Ser Ile Lys 
                725                 730                 735     


Ile Pro Val Cys Ile Lys Val Ile Glu Asp Lys Ser Gly Arg Gln Ser 
            740                 745                 750         


Phe Gln Ala Val Thr Asp His Met Leu Ala Ile Gly Ser Leu Asp His 
        755                 760                 765             


Ala His Ile Val Arg Leu Leu Gly Leu Cys Pro Gly Ser Ser Leu Gln 
    770                 775                 780                 


Leu Val Thr Gln Tyr Leu Pro Leu Gly Ser Leu Leu Asp His Val Arg 
785                 790                 795                 800 


Gln His Arg Gly Ala Leu Gly Pro Gln Leu Leu Leu Asn Trp Gly Val 
                805                 810                 815     


Gln Ile Ala Lys Gly Met Tyr Tyr Leu Glu Glu His Gly Met Val His 
            820                 825                 830         


Arg Asn Leu Ala Ala Arg Asn Val Leu Leu Lys Ser Pro Ser Gln Val 
        835                 840                 845             


Gln Val Ala Asp Phe Gly Val Ala Asp Leu Leu Pro Pro Asp Asp Lys 
    850                 855                 860                 


Gln Leu Leu Tyr Ser Glu Ala Lys Thr Pro Ile Lys Trp Met Ala Leu 
865                 870                 875                 880 


Glu Ser Ile His Phe Gly Lys Tyr Thr His Gln Ser Asp Val Trp Ser 
                885                 890                 895     


Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ala Glu Pro Tyr 
            900                 905                 910         


Ala Gly Leu Arg Leu Ala Glu Val Pro Asp Leu Leu Glu Lys Gly Glu 
        915                 920                 925             


Arg Leu Ala Gln Pro Gln Ile Cys Thr Ile Asp Val Tyr Met Val Met 
    930                 935                 940                 


Val Lys Cys Trp Met Ile Asp Glu Asn Ile Arg Pro Thr Phe Lys Glu 
945                 950                 955                 960 


Leu Ala Asn Glu Phe Thr Arg Met Ala Arg Asp Pro Pro Arg Tyr Leu 
                965                 970                 975     


Val Ile Lys Arg Glu Ser Gly Pro Gly Ile Ala Pro Gly Pro Glu Pro 
            980                 985                 990         


His Gly Leu Thr Asn Lys Lys Leu  Glu Glu Val Glu Leu  Glu Pro Glu 
        995                 1000                 1005             


Leu Asp  Leu Asp Leu Asp Leu  Glu Ala Glu Glu Asp  Asn Leu Ala 
    1010                 1015                 1020             


Thr Thr  Thr Leu Gly Ser Ala  Leu Ser Leu Pro Val  Gly Thr Leu 
    1025                 1030                 1035             


Asn Arg  Pro Arg Gly Ser Gln  Ser Leu Leu Ser Pro  Ser Ser Gly 
    1040                 1045                 1050             


Tyr Met  Pro Met Asn Gln Gly  Asn Leu Gly Glu Ser  Cys Gln Glu 
    1055                 1060                 1065             


Ser Ala  Val Ser Gly Ser Ser  Glu Arg Cys Pro Arg  Pro Val Ser 
    1070                 1075                 1080             


Leu His  Pro Met Pro Arg Gly  Cys Leu Ala Ser Glu  Ser Ser Glu 
    1085                 1090                 1095             


Gly His  Val Thr Gly Ser Glu  Ala Glu Leu Gln Glu  Lys Val Ser 
    1100                 1105                 1110             


Met Cys  Arg Ser Arg Ser Arg  Ser Arg Ser Pro Arg  Pro Arg Gly 
    1115                 1120                 1125             


Asp Ser  Ala Tyr His Ser Gln  Arg His Ser Leu Leu  Thr Pro Val 
    1130                 1135                 1140             


Thr Pro  Leu Ser Pro Pro Gly  Leu Glu Glu Glu Asp  Val Asn Gly 
    1145                 1150                 1155             


Tyr Val  Met Pro Asp Thr His  Leu Lys Gly Thr Pro  Ser Ser Arg 
    1160                 1165                 1170             


Glu Gly  Thr Leu Ser Ser Val  Gly Leu Ser Ser Val  Leu Gly Thr 
    1175                 1180                 1185             


Glu Glu  Glu Asp Glu Asp Glu  Glu Tyr Glu Tyr Met  Asn Arg Arg 
    1190                 1195                 1200             


Arg Arg  His Ser Pro Pro His  Pro Pro Arg Pro Ser  Ser Leu Glu 
    1205                 1210                 1215             


Glu Leu  Gly Tyr Glu Tyr Met  Asp Val Gly Ser Asp  Leu Ser Ala 
    1220                 1225                 1230             


Ser Leu  Gly Ser Thr Gln Ser  Cys Pro Leu His Pro  Val Pro Ile 
    1235                 1240                 1245             


Met Pro  Thr Ala Gly Thr Thr  Pro Asp Glu Asp Tyr  Glu Tyr Met 
    1250                 1255                 1260             


Asn Arg  Gln Arg Asp Gly Gly  Gly Pro Gly Gly Asp  Tyr Ala Ala 
    1265                 1270                 1275             


Met Gly  Ala Cys Pro Ala Ser  Glu Gln Gly Tyr Glu  Glu Met Arg 
    1280                 1285                 1290             


Ala Phe  Gln Gly Pro Gly His  Gln Ala Pro His Val  His Tyr Ala 
    1295                 1300                 1305             


Arg Leu  Lys Thr Leu Arg Ser  Leu Glu Ala Thr Asp  Ser Ala Phe 
    1310                 1315                 1320             


Asp Asn  Pro Asp Tyr Trp His  Ser Arg Leu Phe Pro  Lys Ala Asn 
    1325                 1330                 1335             


Ala Gln  Arg Thr 
    1340         


<210> 6
<211> 4721
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown:
      HER3 sequence

<400> 6
ctccgaggtg ggcaactctc aggcagtgtg tcctgggact ctgaatggcc tgagtgtgac       60

cggcgatgct gagaaccaat accagacact gtacaagctc tacgagaggt gtgaggtggt      120

gatggggaac cttgagattg tgctcacggg acacaatgcc gacctctcct tcctgcagtg      180

gattcgagaa gtgacaggct atgtcctcgt ggccatgaat gaattctcta ctctaccatt      240

gcccaacctc cgcgtggtgc gagggaccca ggtctacgat gggaagtttg ccatcttcgt      300

catgttgaac tataacacca actccagcca cgctctgcgc cagctccgct tgactcagct      360

caccgagatt ctgtcagggg gtgtttatat tgagaagaac gataagcttt gtcacatgga      420

cacaattgac tggagggaca tcgtgaggga ccgagatgct gagatagtgg tgaaggacaa      480

tggcagaagc tgtcccccct gtcatgaggt ttgcaagggg cgatgctggg gtcctggatc      540

agaagactgc cagacattga ccaagaccat ctgtgctcct cagtgtaatg gtcactgctt      600

tgggcccaac cccaaccagt gctgccatga tgagtgtgcc gggggctgct caggccctca      660

ggacacagac tgctttgcct gccggcactt caatgacagt ggagcctgtg tacctcgctg      720

tccacagcct cttgtctaca acaagctaac tttccagctg gaacccaatc cccacaccaa      780

gtatcagtat ggaggagttt gtgtagccag ctgtccccat aactttgtgg tggatcaaac      840

atcctgtgtc agggcctgtc ctcctgacaa gatggaagta gataaaaatg ggctcaagat      900

gtgtgagcct tgtgggggac tatgtcccaa agcctgtgag ggaacaggct ctgggagccg      960

cttccagact gtggactcga gcaacattga tggatttgtg aactgcacca agatcctggg     1020

caacctggac tttctgatca ccggcctcaa tggagacccc tggcacaaga tccctgccct     1080

ggacccagag aagctcaatg tcttccggac agtacgggag atcacaggtt acctgaacat     1140

ccagtcctgg ccgccccaca tgcacaactt cagtgttttt tccaatttga caaccattgg     1200

aggcagaagc ctctacaacc ggggcttctc attgttgatc atgaagaact tgaatgtcac     1260

atctctgggc ttccgatccc tgaaggaaat tagtgctggg cgtatctata taagtgccaa     1320

taggcagctc tgctaccacc actctttgaa ctggaccaag gtgcttcggg ggcctacgga     1380

agagcgacta gacatcaagc ataatcggcc gcgcagagac tgcgtggcag agggcaaagt     1440

gtgtgaccca ctgtgctcct ctgggggatg ctggggccca ggccctggtc agtgcttgtc     1500

ctgtcgaaat tatagccgag gaggtgtctg tgtgacccac tgcaactttc tgaatgggga     1560

gcctcgagaa tttgcccatg aggccgaatg cttctcctgc cacccggaat gccaacccat     1620

ggggggcact gccacatgca atggctcggg ctctgatact tgtgctcaat gtgcccattt     1680

tcgagatggg ccccactgtg tgagcagctg cccccatgga gtcctaggtg ccaagggccc     1740

aatctacaag tacccagatg ttcagaatga atgtcggccc tgccatgaga actgcaccca     1800

ggggtgtaaa ggaccagagc ttcaagactg tttaggacaa acactggtgc tgatcggcaa     1860

aacccatctg acaatggctt tgacagtgat agcaggattg gtagtgattt tcatgatgct     1920

gggcggcact tttctctact ggcgtgggcg ccggattcag aataaaaggg ctatgaggcg     1980

atacttggaa cggggtgaga gcatagagcc tctggacccc agtgagaagg ctaacaaagt     2040

cttggccaga atcttcaaag agacagagct aaggaagctt aaagtgcttg gctcgggtgt     2100

ctttggaact gtgcacaaag gagtgtggat ccctgagggt gaatcaatca agattccagt     2160

ctgcattaaa gtcattgagg acaagagtgg acggcagagt tttcaagctg tgacagatca     2220

tatgctggcc attggcagcc tggaccatgc ccacattgta aggctgctgg gactatgccc     2280

agggtcatct ctgcagcttg tcactcaata tttgcctctg ggttctctgc tggatcatgt     2340

gagacaacac cggggggcac tggggccaca gctgctgctc aactggggag tacaaattgc     2400

caagggaatg tactaccttg aggaacatgg tatggtgcat agaaacctgg ctgcccgaaa     2460

cgtgctactc aagtcaccca gtcaggttca ggtggcagat tttggtgtgg ctgacctgct     2520

gcctcctgat gataagcagc tgctatacag tgaggccaag actccaatta agtggatggc     2580

ccttgagagt atccactttg ggaaatacac acaccagagt gatgtctgga gctatggtgt     2640

gacagtttgg gagttgatga ccttcggggc agagccctat gcagggctac gattggctga     2700

agtaccagac ctgctagaga agggggagcg gttggcacag ccccagatct gcacaattga     2760

tgtctacatg gtgatggtca agtgttggat gattgatgag aacattcgcc caacctttaa     2820

agaactagcc aatgagttca ccaggatggc ccgagaccca ccacggtatc tggtcataaa     2880

gagagagagt gggcctggaa tagcccctgg gccagagccc catggtctga caaacaagaa     2940

gctagaggaa gtagagctgg agccagaact agacctagac ctagacttgg aagcagagga     3000

ggacaacctg gcaaccacca cactgggctc cgccctcagc ctaccagttg gaacacttaa     3060

tcggccacgt gggagccaga gccttttaag tccatcatct ggatacatgc ccatgaacca     3120

gggtaatctt ggggggtctt gccaggagtc tgcagtttct gggagcagtg aacggtgccc     3180

ccgtccagtc tctctacacc caatgccacg gggatgcctg gcatcagagt catcagaggg     3240

gcatgtaaca ggctctgagg ctgagctcca ggagaaagtg tcaatgtgta gaagccggag     3300

caggagccgg agcccacggc cacgcggaga tagcgcctac cattcccagc gccacagtct     3360

gctgactcct gttaccccac tctccccacc cgggttagag gaagaggatg tcaacggtta     3420

tgtcatgcca gatacacacc tcaaaggtac tccctcctcc cgggaaggca ccctttcttc     3480

agtgggtctc agttctgtcc tgggtactga agaagaagat gaagatgagg agtatgaata     3540

catgaaccgg aggagaaggc acagtccacc tcatccccct aggccaagtt cccttgagga     3600

gctgggttat gagtacatgg atgtggggtc agacctcagt gcctctctgg gcagcacaca     3660

gagttgccca ctccaccctg tacccatcat gcccactgca ggcacaactc cagatgaaga     3720

ctatgaatat atgaatcggc aacgagatgg aggtggtcct gggggtgatt atgcagccat     3780

gggggcctgc ccagcatctg agcaagggta tgaagagatg agagcttttc aggggcctgg     3840

acatcaggcc ccccatgtcc attatgcccg cctaaaaact ctacgtagct tagaggctac     3900

agactctgcc tttgataacc ctgattactg gcatagcagg cttttcccca aggctaatgc     3960

ccagagaacg taactcctgc tccctgtggc actcagggag catttaatgg cagctagtgc     4020

ctttagaggg taccgtcttc tccctattcc ctctctctcc caggtcccag ccccttttcc     4080

ccagtcccag acaattccat tcaatctttg gaggctttta aacattttga cacaaaattc     4140

ttatggtatg tagccagctg tgcactttct tctctttccc aaccccagga aaggttttcc     4200

ttattttgtg tgctttccca gtcccattcc tcagcttctt cacaggcact cctggagata     4260

tgaaggatta ctctccatat cccttcctct caggctcttg actacttgga actaggctct     4320

tatgtgtgcc tttgtttccc atcagactgt caagaagagg aaagggagga aacctagcag     4380

aggaaagtgt aattttggtt tatgactctt aaccccctag aaagacagaa gcttaaaatc     4440

tgtgaagaaa gaggttagga gtagatattg attactatca taattcagca cttaactatg     4500

agccaggcat catactaaac ttcacctaca ttatctcact tagtccttta tcatccttaa     4560

aacaattctg tgacatacat attatctcat tttacacaaa gggaagtcgg gcatggtggc     4620

tcatgcctgt aatctcagca ctttgggagg ctgaggcaga aggattacct gaggcaagga     4680

gtttgagacc agcttagcca acatagtaag acccccatct c                         4721


<210> 7
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 7
ggaaccuguc uccacaaagt t                                                 21


<210> 8
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 8
gaagaaugca gguuuaauat t                                                 21


<210> 9
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> CDS
<222> (1)..(48)

<400> 9
ggc ctg gag aag ctg ggt atc ttc gtc aag acc gtg acg gag ggt ggt         48
Gly Leu Glu Lys Leu Gly Ile Phe Val Lys Thr Val Thr Glu Gly Gly           
1               5                   10                  15                


<210> 10
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Gly Leu Glu Lys Leu Gly Ile Phe Val Lys Thr Val Thr Glu Gly Gly 
1               5                   10                  15      


<210> 11
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 11
ggcctggaga agctgggtat tgacggaggg tggt                                   34


<210> 12
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 12
cttcgtcaag accg                                                         14


<210> 13
<211> 46
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 13
ggcctggaga agctgggtat cttcgtcaag actgacggag ggtggt                      46


<210> 14
<211> 47
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 14
ggcctggaga agctgggtat cttcgtcaag accggacgga gggtggt                     47


<210> 15
<211> 11603
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 15
tggaagggct aattcactcc caaagaagac aagatatcct tgatctgtgg atctaccaca       60

cacaaggcta cttccctgat tagcagaact acacaccagg gccaggggtc agatatccac      120

tgacctttgg atggtgctac aagctagtac cagttgagcc agataaggta gaagaggcca      180

ataaaggaga gaacaccagc ttgttacacc ctgtgagcct gcatgggatg gatgacccgg      240

agagagaagt gttagagtgg aggtttgaca gccgcctagc atttcatcac gtggcccgag      300

agctgcatcc ggagtacttc aagaactgct gatatcgagc ttgctacaag ggactttccg      360

ctggggactt tccagggagg cgtggcctgg gcgggactgg ggagtggcga gccctcagat      420

cctgcatata agcagctgct ttttgcctgt actgggtctc tctggttaga ccagatctga      480

gcctgggagc tctctggcta actagggaac ccactgctta agcctcaata aagcttgcct      540

tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact ctggtaacta gagatccctc      600

agaccctttt agtcagtgtg gaaaatctct agcagtggcg cccgaacagg gacttgaaag      660

cgaaagggaa accagaggag ctctctcgac gcaggactcg gcttgctgaa gcgcgcacgg      720

caagaggcga ggggcggcga ctggtgagta cgccaaaaat tttgactagc ggaggctaga      780

aggagagaga tgggtgcgag agcgtcagta ttaagcgggg gagaattaga tcgcgatggg      840

aaaaaattcg gttaaggcca gggggaaaga aaaaatataa attaaaacat atagtatggg      900

caagcaggga gctagaacga ttcgcagtta atcctggcct gttagaaaca tcagaaggct      960

gtagacaaat actgggacag ctacaaccat cccttcagac aggatcagaa gaacttagat     1020

cattatataa tacagtagca accctctatt gtgtgcatca aaggatagag ataaaagaca     1080

ccaaggaagc tttagacaag atagaggaag agcaaaacaa aagtaagacc accgcacagc     1140

aagcggccgg ccgctgatct tcagacctgg aggaggagat atgagggaca attggagaag     1200

tgaattatat aaatataaag tagtaaaaat tgaaccatta ggagtagcac ccaccaaggc     1260

aaagagaaga gtggtgcaga gagaaaaaag agcagtggga ataggagctt tgttccttgg     1320

gttcttggga gcagcaggaa gcactatggg cgcagcgtca atgacgctga cggtacaggc     1380

cagacaatta ttgtctggta tagtgcagca gcagaacaat ttgctgaggg ctattgaggc     1440

gcaacagcat ctgttgcaac tcacagtctg gggcatcaag cagctccagg caagaatcct     1500

ggctgtggaa agatacctaa aggatcaaca gctcctgggg atttggggtt gctctggaaa     1560

actcatttgc accactgctg tgccttggaa tgctagttgg agtaataaat ctctggaaca     1620

gatttggaat cacacgacct ggatggagtg ggacagagaa attaacaatt acacaagctt     1680

aatacactcc ttaattgaag aatcgcaaaa ccagcaagaa aagaatgaac aagaattatt     1740

ggaattagat aaatgggcaa gtttgtggaa ttggtttaac ataacaaatt ggctgtggta     1800

tataaaatta ttcataatga tagtaggagg cttggtaggt ttaagaatag tttttgctgt     1860

actttctata gtgaatagag ttaggcaggg atattcacca ttatcgtttc agacccacct     1920

cccaaccccg aggggacccg acaggcccga aggaatagaa gaagaaggtg gagagagaga     1980

cagagacaga tccattcgat tagtgaacgg atctcgacgg tatcgccttt aaaagaaaag     2040

gggggattgg ggggtacagt gcaggggaaa gaatagtaga cataatagca acagacatac     2100

aaactaaaga actacaaaaa caaattacaa aaattcaaaa ttttcgggtt tattacaggg     2160

acagcagaga tccagtttat cgacttaact tgtttattgc agcttataat ggttacaaat     2220

aaggcaatag catcacaaat ttcacaaata aggcattttt ttcactgcat tctagttttg     2280

gtttgtccaa actcatcaat gtatcttatc atgtctggat ctcaaatccc tcggaagctg     2340

cgcctgtctt aggttggagt gatacatttt tatcactttt acccgtcttt ggattaggca     2400

gtagctctga cggccctcct gtcttaggtt agtgaaaaat gtcactctct tacccgtcat     2460

tggctgtcca gcttagctcg caggggaggt ggtctggatc cgccggcacc ggtgatcagt     2520

tatctagact acttgtcgtc gtcgtccttg tagtcgatgt cgtggtcctt gtagtcgccg     2580

tcgtggtcct tgtagtcggc gccaccgcct ccaaccactt tgtacaagaa agctgaacga     2640

gaaacgtaaa atgatataaa tatcaatata ttaaattaga ttttgcataa aaaacagact     2700

acataatact gtaaaacaca acatatccag tcactatgaa tcaactactt agatggtatt     2760

agtgacctgt agtcgactaa gttggcagca tcacccgacg cactttgcgc cgaataaata     2820

cctgtgacgg aagatcactt cgcagaataa ataaatcctg gtgtccctgt tgataccggg     2880

aagccctggg ccaacttttg gcgaaaatga gacgttgatc ggcacgtaag aggttccaac     2940

tttcaccata atgaaataag atcactaccg ggcgtatttt ttgagttatc gagattttca     3000

ggagctaagg aagctaaaat ggagaaaaaa atcactggat ataccaccgt tgatatatcc     3060

caatggcatc gtaaagaaca ttttgaggca tttcagtcag ttgctcaatg tacctataac     3120

cagaccgttc agctggatat tacggccttt ttaaagaccg taaagaaaaa taagcacaag     3180

ttttatccgg cctttattca cattcttgcc cgcctgatga atgctcatcc ggaattccgt     3240

atggcaatga aagacggtga gctggtgata tgggatagtg ttcacccttg ttacaccgtt     3300

ttccatgagc aaactgaaac gttttcatcg ctctggagtg aataccacga cgatttccgg     3360

cagtttctac acatatattc gcaagatgtg gcgtgttacg gtgaaaacct ggcctatttc     3420

cctaaagggt ttattgagaa tatgtttttc gtctcagcca atccctgggt gagtttcacc     3480

agttttgatt taaacgtggc caatatggac aacttcttcg cccccgtttt caccatgggc     3540

aaatattata cgcaaggcga caaggtgctg atgccgctgg cgattcaggt tcatcatgcc     3600

gtttgtgatg gcttccatgt cggcagaatg cttaatgaat tacaacagta ctgcgatgag     3660

tggcaggggg ggcgtaaacg ccgcgtggat ccggcttact aaaagccaga taacagtatg     3720

cgtatttgcg cgctgatttt tgcggtataa gaatatatac tgatatgtat acccgaagta     3780

tgtcaaaaag aggtatgcta tgaagcagcg tattacagtg acagttgaca gcgacagcta     3840

tcagttgctc aaggcatata tgatgtcaat atctccggtc tggtaagcac aaccatgcag     3900

aatgaagccc gtcgtctgcg tgccgaacgc tggaaagcgg aaaatcagga agggatggct     3960

gaggtcgccc ggtttattga aatgaacggc tcttttgctg acgagaacag gggctggtga     4020

aatgcagttt aaggtttaca cctataaaag agagagccgt tatcgtctgt ttgtggatgt     4080

acagagtgat attattgaca cgcccgggcg acggatggtg atccccctgg ccagtgcacg     4140

tctgctgtca gataaagtct cccgtgaact ttacccggtg gtgcatatcg gggatgaaag     4200

ctggcgcatg atgaccaccg atatggccag tgtgccggtc tccgttatcg gggaagaagt     4260

ggctgatctc agccaccgcg aaaatgacat caaaaacgcc attaacctga tgttctgggg     4320

aatataaatg tcaggctccc ttatacacag ccagtctgca ggtcgataca gtagaaatta     4380

cagaaacttt atcacgttta gtaagtatag aggctgaaaa tccagatgaa gccgaacgac     4440

ttgtaagaga aaagtataag agttgtgaaa ttgttcttga tgcagatgat tttcaggact     4500

atgacactag cgtatatgaa taggtagatg tttttatttt gtcacacaaa aaagaggctc     4560

gcacctcttt ttcttatttc tttttatgat ttaatacggc attgaggaca atagcgagta     4620

ggctggatac gacgattccg tttgagaaga acatttggaa ggctgtcggt cgactaagtt     4680

ggcagcatca cccgaagaac atttggaagg ctgtcggtcg actacaggtc actaatacca     4740

tctaagtagt tgattcatag tgactggata tgttgtgttt tacagtatta tgtagtctgt     4800

tttttatgca aaatctaatt taatatattg atatttatat cattttacgt ttctcgttca     4860

gcttttttgt acaaacttgt ggtaccggtg tatacgggaa ttctttacga gggtaggaag     4920

tggtacggaa agttggtata agacaaaagt gttgtggaat tgaagtttac tcaaaaaatc     4980

agcactcttt tataggcgcc ctggtttaca taagcaaagc ttatacgttc tctatcactg     5040

atagggagta aactggatat acgttctcta tcactgatag ggagtaaact gtagatacgt     5100

tctctatcac tgatagggag taaactggtc atacgttctc tatcactgat agggagtaaa     5160

ctccttatac gttctctatc actgataggg agtaaagtct gcatacgttc tctatcactg     5220

atagggagta aactcttcat acgttctcta tcactgatag ggagtaaact cgaggtgata     5280

attccacggg gttggggttg cgccttttcc aaggcagccc tgggtttgcg cagggacgcg     5340

gctgctctgg gcgtggttcc gggaaacgca gcggcgccga ccctgggtct cgcacattct     5400

tcacgtccgt tcgcagcgtc acccggatct tcgccgctac ccttgtgggc cccccggcga     5460

cgcttcctgc tccgccccta agtcgggaag gttccttgcg gttcgcggcg tgccggacgt     5520

gacaaacgga agccgcacgt ctcactagta ccctcgcaga cggacagcgc cagggagcaa     5580

tggcagcgcg ccgaccgcga tgggctgtgg ccaatagcgg ctgctcagca gggcgcgccg     5640

agagcagcgg ccgggaaggg gcggtgcggg aggcggggtg tggggcggta gtgtgggccc     5700

tgttcctgcc cgcgcggtgt tccgcattct gcaagcctcc ggagcgcacg tcggcagtcg     5760

gctccctcgt tgaccgaatc accgacctct ctccccaggg ggatcatcga attaccatgt     5820

ctagactgga caagagcaaa gtcataaact ctgctctgga attactcaat ggagtcggta     5880

tcgaaggcct gacgacaagg aaactcgctc aaaagctggg agttgagcag cctaccctgt     5940

actggcacgt gaagaacaag cgggccctgc tcgatgccct gccaatcgag atgctggaca     6000

ggcatcatac ccactcctgc cccctggaag gcgagtcatg gcaagacttt ctgcggaaca     6060

acgccaagtc ataccgctgt gctctcctct cacatcgcga cggggctaaa gtgcatctcg     6120

gcacccgccc aacagagaaa cagtacgaaa ccctggaaaa tcagctcgcg ttcctgtgtc     6180

agcaaggctt ctccctggag aacgcactgt acgctctgtc cgccgtgggc cactttacac     6240

tgggctgcgt attggaggaa caggagcatc aagtagcaaa agaggaaaga gagacaccta     6300

ccaccgattc tatgccccca cttctgaaac aagcaattga gctgttcgac cggcagggag     6360

ccgaacctgc cttccttttc ggcctggaac taatcatatg tggcctggag aaacagctaa     6420

agtgcgaaag cggcgggccg accgacgccc ttgacgattt tgacttagac atgctcccag     6480

ccgatgccct tgacgacttt gaccttgata tgctgcctgc tgacgctctt gacgattttg     6540

accttgacat gctccccggg taaacgcgcg aatgtgtgtc agttagggtg tggaaagtcc     6600

ccaggctccc cagcaggcag aagtatgcaa agcatgcatc tcaattagtc agcaaccagg     6660

tgtggaaagt ccccaggctc cccagcaggc agaagtatgc aaagcatgca tctcaattag     6720

tcagcaacca tagtcccgcc cctaactccg cccatcccgc ccctaactcc gcccagttcc     6780

gcccattctc cgccccatgg ctgactaatt ttttttattt atgcagaggc cgaggccgcc     6840

tcggcctctg agctattcca gaagtagtga ggaggctttt ttggaggcct aggcttttgc     6900

aaaacgcgac catgaccgag tacaagccca cggtgcgcct cgccacccgc gacgacgtcc     6960

cccgggccgt acgcaccctc gccgccgcgt tcgccgacta ccccgccacg cgccacaccg     7020

tcgacccgga ccgccacatc gagcgggtca ccgagctgca agaactcttc ctcacgcgcg     7080

tcgggctcga catcggcaag gtgtgggtcg cggacgacgg cgccgcggtg gcggtctgga     7140

ccacgccgga gagcgtcgaa gcgggggcgg tgttcgccga gatcggcccg cgcatggccg     7200

agttgagcgg ttcccggctg gccgcgcagc aacagatgga aggcctcctg gcgccgcacc     7260

ggcccaagga gcccgcgtgg ttcctggcca ccgtcggcgt ctcgcccgac caccagggca     7320

agggtctggg cagcgccgtc gtgctccccg gagtggaggc ggccgagcgc gccggggtgc     7380

ccgccttcct ggagacctcc gcgccccgca acctcccctt ctacgagcgg ctcggcttca     7440

ccgtcaccgc cgacgtcgag gtgcccgaag gaccgcgcac ctggtgcatg acccgcaagc     7500

ccggtgcctg aacgcgtctg gaacaatcaa cctctggatt acaaaatttg tgaaagattg     7560

actggtattc ttaactatgt tgctcctttt acgctatgtg gatacgctgc tttaatgcct     7620

ttgtatcatg ctattgcttc ccgtatggct ttcattttct cctccttgta taaatcctgg     7680

ttgctgtctc tttatgagga gttgtggccc gttgtcaggc aacgtggcgt ggtgtgcact     7740

gtgtttgctg acgcaacccc cactggttgg ggcattgcca ccacctgtca gctcctttcc     7800

gggactttcg ctttccccct ccctattgcc acggcggaac tcatcgccgc ctgccttgcc     7860

cgctgctgga caggggctcg gctgttgggc actgacaatt ccgtggtgtt gtcggggaag     7920

ctgacgtcct ttccatggct gctcgcctgt gttgccacct ggattctgcg cgggacgtcc     7980

ttctgctacg tcccttcggc cctcaatcca gcggaccttc cttcccgcgg cctgctgccg     8040

gctctgcggc ctcttccgcg tcttcgcctt cgccctcaga cgagtcggat ctccctttgg     8100

gccgcctccc cgcctggaat taattctgca gtcgagacct agaaaaacat ggagcaatca     8160

caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca caagaggagg     8220

aggaggtggg tttttccagt cacacctcag gtacctttaa gaccaatgac ttacaaggca     8280

gctgtagatc ttagccactt tttaaaagaa aagaggggac tggaagggct aattcactcc     8340

caacgaagac aagatatcct tgatctgtgg atctaccaca cacaaggcta cttccctgat     8400

tagcagaact acacaccagg gccaggggtc agatatccac tgacctttgg atggtgctac     8460

aagctagtac cagttgagcc agataaggta gaagaggcca ataaaggaga gaacaccagc     8520

ttgttacacc ctgtgagcct gcatgggatg gatgacccgg agagagaagt gttagagtgg     8580

aggtttgaca gccgcctagc atttcatcac gtggcccgag agctgcatcc ggagtacttc     8640

aagaactgct gatatcgagc ttgctacaag ggactttccg ctggggactt tccagggagg     8700

cgtggcctgg gcgggactgg ggagtggcga gccctcagat cctgcatata agcagctgct     8760

ttttgcctgt actgggtctc tctggttaga ccagatctga gcctgggagc tctctggcta     8820

actagggaac ccactgctta agcctcaata aagcttgcct tgagtgcttc aagtagtgtg     8880

tgcccgtctg ttgtgtgact ctggtaacta gagatccctc agaccctttt agtcagtgtg     8940

gaaaatctct agcagtagta gttcatgtca tcttattatt cagtatttat aacttgcaaa     9000

gaaatgaata tcagagagtg agaggccttg acattgctag cgttttaccg tcgacctcta     9060

gctagagctt ggcgtaatca tggtcatagc tgtttcctgt gtgaaattgt tatccgctca     9120

caattccaca caacatacga gccggaagca taaagtgtaa agcctggggt gcctaatgag     9180

tgagctaact cacattaatt gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt     9240

cgtgccagct gcattaatga atcggccaac gcgcggggag aggcggtttg cgtattgggc     9300

gctcttccgc ttcctcgctc actgactcgc tgcgctcggt cgttcggctg cggcgagcgg     9360

tatcagctca ctcaaaggcg gtaatacggt tatccacaga atcaggggat aacgcaggaa     9420

agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg     9480

cgtttttcca taggctccgc ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga     9540

ggtggcgaaa cccgacagga ctataaagat accaggcgtt tccccctgga agctccctcg     9600

tgcgctctcc tgttccgacc ctgccgctta ccggatacct gtccgccttt ctcccttcgg     9660

gaagcgtggc gctttctcat agctcacgct gtaggtatct cagttcggtg taggtcgttc     9720

gctccaagct gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc gccttatccg     9780

gtaactatcg tcttgagtcc aacccggtaa gacacgactt atcgccactg gcagcagcca     9840

ctggtaacag gattagcaga gcgaggtatg taggcggtgc tacagagttc ttgaagtggt     9900

ggcctaacta cggctacact agaagaacag tatttggtat ctgcgctctg ctgaagccag     9960

ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa acaaaccacc gctggtagcg    10020

gtttttttgt ttgcaagcag cagattacgc gcagaaaaaa aggatctcaa gaagatcctt    10080

tgatcttttc tacggggtct gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg    10140

tcatgagatt atcaaaaagg atcttcacct agatcctttt aaattaaaaa tgaagtttta    10200

aatcaatcta aagtatatat gagtaaactt ggtctgacag ttaccaatgc ttaatcagtg    10260

aggcacctat ctcagcgatc tgtctatttc gttcatccat agttgcctga ctccccgtcg    10320

tgtagataac tacgatacgg gagggcttac catctggccc cagtgctgca atgataccgc    10380

gagacccacg ctcaccggct ccagatttat cagcaataaa ccagccagcc ggaagggccg    10440

agcgcagaag tggtcctgca actttatccg cctccatcca gtctattaat tgttgccggg    10500

aagctagagt aagtagttcg ccagttaata gtttgcgcaa cgttgttgcc attgctacag    10560

gcatcgtggt gtcacgctcg tcgtttggta tggcttcatt cagctccggt tcccaacgat    10620

caaggcgagt tacatgatcc cccatgttgt gcaaaaaagc ggttagctcc ttcggtcctc    10680

cgatcgttgt cagaagtaag ttggccgcag tgttatcact catggttatg gcagcactgc    10740

ataattctct tactgtcatg ccatccgtaa gatgcttttc tgtgactggt gagtactcaa    10800

ccaagtcatt ctgagaatag tgtatgcggc gaccgagttg ctcttgcccg gcgtcaatac    10860

gggataatac cgcgccacat agcagaactt taaaagtgct catcattgga aaacgttctt    10920

cggggcgaaa actctcaagg atcttaccgc tgttgagatc cagttcgatg taacccactc    10980

gtgcacccaa ctgatcttca gcatctttta ctttcaccag cgtttctggg tgagcaaaaa    11040

caggaaggca aaatgccgca aaaaagggaa taagggcgac acggaaatgt tgaatactca    11100

tactcttcct ttttcaatat tattgaagca tttatcaggg ttattgtctc atgagcggat    11160

acatatttga atgtatttag aaaaataaac aaataggggt tccgcgcaca tttccccgaa    11220

aagtgccacc tgacgtcgac ggatcgggag atcaacttgt ttattgcagc ttataatggt    11280

tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct    11340

agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatcaa ctggataact    11400

caagctaacc aaaatcatcc caaacttccc accccatacc ctattaccac tgccaattac    11460

ctagtggttt catttactct aaacctgtga ttcctctgaa ttattttcat tttaaagaaa    11520

ttgtatttgt taaatatgta ctacaaactt agtagttttt aaagaaattg tatttgttaa    11580

atatgtacta caaacttagt agt                                            11603


<210> 16
<211> 11612
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 16
tggaagggct aattcactcc caaagaagac aagatatcct tgatctgtgg atctaccaca       60

cacaaggcta cttccctgat tagcagaact acacaccagg gccaggggtc agatatccac      120

tgacctttgg atggtgctac aagctagtac cagttgagcc agataaggta gaagaggcca      180

ataaaggaga gaacaccagc ttgttacacc ctgtgagcct gcatgggatg gatgacccgg      240

agagagaagt gttagagtgg aggtttgaca gccgcctagc atttcatcac gtggcccgag      300

agctgcatcc ggagtacttc aagaactgct gatatcgagc ttgctacaag ggactttccg      360

ctggggactt tccagggagg cgtggcctgg gcgggactgg ggagtggcga gccctcagat      420

cctgcatata agcagctgct ttttgcctgt actgggtctc tctggttaga ccagatctga      480

gcctgggagc tctctggcta actagggaac ccactgctta agcctcaata aagcttgcct      540

tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact ctggtaacta gagatccctc      600

agaccctttt agtcagtgtg gaaaatctct agcagtggcg cccgaacagg gacttgaaag      660

cgaaagggaa accagaggag ctctctcgac gcaggactcg gcttgctgaa gcgcgcacgg      720

caagaggcga ggggcggcga ctggtgagta cgccaaaaat tttgactagc ggaggctaga      780

aggagagaga tgggtgcgag agcgtcagta ttaagcgggg gagaattaga tcgcgatggg      840

aaaaaattcg gttaaggcca gggggaaaga aaaaatataa attaaaacat atagtatggg      900

caagcaggga gctagaacga ttcgcagtta atcctggcct gttagaaaca tcagaaggct      960

gtagacaaat actgggacag ctacaaccat cccttcagac aggatcagaa gaacttagat     1020

cattatataa tacagtagca accctctatt gtgtgcatca aaggatagag ataaaagaca     1080

ccaaggaagc tttagacaag atagaggaag agcaaaacaa aagtaagacc accgcacagc     1140

aagcggccgg ccgctgatct tcagacctgg aggaggagat atgagggaca attggagaag     1200

tgaattatat aaatataaag tagtaaaaat tgaaccatta ggagtagcac ccaccaaggc     1260

aaagagaaga gtggtgcaga gagaaaaaag agcagtggga ataggagctt tgttccttgg     1320

gttcttggga gcagcaggaa gcactatggg cgcagcgtca atgacgctga cggtacaggc     1380

cagacaatta ttgtctggta tagtgcagca gcagaacaat ttgctgaggg ctattgaggc     1440

gcaacagcat ctgttgcaac tcacagtctg gggcatcaag cagctccagg caagaatcct     1500

ggctgtggaa agatacctaa aggatcaaca gctcctgggg atttggggtt gctctggaaa     1560

actcatttgc accactgctg tgccttggaa tgctagttgg agtaataaat ctctggaaca     1620

gatttggaat cacacgacct ggatggagtg ggacagagaa attaacaatt acacaagctt     1680

aatacactcc ttaattgaag aatcgcaaaa ccagcaagaa aagaatgaac aagaattatt     1740

ggaattagat aaatgggcaa gtttgtggaa ttggtttaac ataacaaatt ggctgtggta     1800

tataaaatta ttcataatga tagtaggagg cttggtaggt ttaagaatag tttttgctgt     1860

actttctata gtgaatagag ttaggcaggg atattcacca ttatcgtttc agacccacct     1920

cccaaccccg aggggacccg acaggcccga aggaatagaa gaagaaggtg gagagagaga     1980

cagagacaga tccattcgat tagtgaacgg atctcgacgg tatcgccttt aaaagaaaag     2040

gggggattgg ggggtacagt gcaggggaaa gaatagtaga cataatagca acagacatac     2100

aaactaaaga actacaaaaa caaattacaa aaattcaaaa ttttcgggtt tattacaggg     2160

acagcagaga tccagtttat cgacttaact tgtttattgc agcttataat ggttacaaat     2220

aaggcaatag catcacaaat ttcacaaata aggcattttt ttcactgcat tctagttttg     2280

gtttgtccaa actcatcaat gtatcttatc atgtctggat ctcaaatccc tcggaagctg     2340

cgcctgtctt aggttggagt gatacatttt tatcactttt acccgtcttt ggattaggca     2400

gtagctctga cggccctcct gtcttaggtt agtgaaaaat gtcactctct tacccgtcat     2460

tggctgtcca gcttagctcg caggggaggt ggtctggatc cgccggcacc ggtgatcagt     2520

tatctagact aaaccacttt gtacaagaaa gctgaacgag aaacgtaaaa tgatataaat     2580

atcaatatat taaattagat tttgcataaa aaacagacta cataatactg taaaacacaa     2640

catatccagt cactatgaat caactactta gatggtatta gtgacctgta gtcgactaag     2700

ttggcagcat cacccgacgc actttgcgcc gaataaatac ctgtgacgga agatcacttc     2760

gcagaataaa taaatcctgg tgtccctgtt gataccggga agccctgggc caacttttgg     2820

cgaaaatgag acgttgatcg gcacgtaaga ggttccaact ttcaccataa tgaaataaga     2880

tcactaccgg gcgtattttt tgagttatcg agattttcag gagctaagga agctaaaatg     2940

gagaaaaaaa tcactggata taccaccgtt gatatatccc aatggcatcg taaagaacat     3000

tttgaggcat ttcagtcagt tgctcaatgt acctataacc agaccgttca gctggatatt     3060

acggcctttt taaagaccgt aaagaaaaat aagcacaagt tttatccggc ctttattcac     3120

attcttgccc gcctgatgaa tgctcatccg gaattccgta tggcaatgaa agacggtgag     3180

ctggtgatat gggatagtgt tcacccttgt tacaccgttt tccatgagca aactgaaacg     3240

ttttcatcgc tctggagtga ataccacgac gatttccggc agtttctaca catatattcg     3300

caagatgtgg cgtgttacgg tgaaaacctg gcctatttcc ctaaagggtt tattgagaat     3360

atgtttttcg tctcagccaa tccctgggtg agtttcacca gttttgattt aaacgtggcc     3420

aatatggaca acttcttcgc ccccgttttc accatgggca aatattatac gcaaggcgac     3480

aaggtgctga tgccgctggc gattcaggtt catcatgccg tttgtgatgg cttccatgtc     3540

ggcagaatgc ttaatgaatt acaacagtac tgcgatgagt ggcagggggg gcgtaaacgc     3600

cgcgtggatc cggcttacta aaagccagat aacagtatgc gtatttgcgc gctgattttt     3660

gcggtataag aatatatact gatatgtata cccgaagtat gtcaaaaaga ggtatgctat     3720

gaagcagcgt attacagtga cagttgacag cgacagctat cagttgctca aggcatatat     3780

gatgtcaata tctccggtct ggtaagcaca accatgcaga atgaagcccg tcgtctgcgt     3840

gccgaacgct ggaaagcgga aaatcaggaa gggatggctg aggtcgcccg gtttattgaa     3900

atgaacggct cttttgctga cgagaacagg ggctggtgaa atgcagttta aggtttacac     3960

ctataaaaga gagagccgtt atcgtctgtt tgtggatgta cagagtgata ttattgacac     4020

gcccgggcga cggatggtga tccccctggc cagtgcacgt ctgctgtcag ataaagtctc     4080

ccgtgaactt tacccggtgg tgcatatcgg ggatgaaagc tggcgcatga tgaccaccga     4140

tatggccagt gtgccggtct ccgttatcgg ggaagaagtg gctgatctca gccaccgcga     4200

aaatgacatc aaaaacgcca ttaacctgat gttctgggga atataaatgt caggctccct     4260

tatacacagc cagtctgcag gtcgatacag tagaaattac agaaacttta tcacgtttag     4320

taagtataga ggctgaaaat ccagatgaag ccgaacgact tgtaagagaa aagtataaga     4380

gttgtgaaat tgttcttgat gcagatgatt ttcaggacta tgacactagc gtatatgaat     4440

aggtagatgt ttttattttg tcacacaaaa aagaggctcg cacctctttt tcttatttct     4500

ttttatgatt taatacggca ttgaggacaa tagcgagtag gctggatacg acgattccgt     4560

ttgagaagaa catttggaag gctgtcggtc gactaagttg gcagcatcac ccgaagaaca     4620

tttggaaggc tgtcggtcga ctacaggtca ctaataccat ctaagtagtt gattcatagt     4680

gactggatat gttgtgtttt acagtattat gtagtctgtt ttttatgcaa aatctaattt     4740

aatatattga tatttatatc attttacgtt tctcgttcag cttttttgta caaacttgtg     4800

gcgccaccgc ctcccttgtc gtcgtcgtcc ttgtagtcga tgtcgtggtc cttgtagtcg     4860

ccgtcgtggt ccttgtagtc catggtggcg gtaccggtgt atacgggaat tctttacgag     4920

ggtaggaagt ggtacggaaa gttggtataa gacaaaagtg ttgtggaatt gaagtttact     4980

caaaaaatca gcactctttt ataggcgccc tggtttacat aagcaaagct tatacgttct     5040

ctatcactga tagggagtaa actggatata cgttctctat cactgatagg gagtaaactg     5100

tagatacgtt ctctatcact gatagggagt aaactggtca tacgttctct atcactgata     5160

gggagtaaac tccttatacg ttctctatca ctgataggga gtaaagtctg catacgttct     5220

ctatcactga tagggagtaa actcttcata cgttctctat cactgatagg gagtaaactc     5280

gaggtgataa ttccacgggg ttggggttgc gccttttcca aggcagccct gggtttgcgc     5340

agggacgcgg ctgctctggg cgtggttccg ggaaacgcag cggcgccgac cctgggtctc     5400

gcacattctt cacgtccgtt cgcagcgtca cccggatctt cgccgctacc cttgtgggcc     5460

ccccggcgac gcttcctgct ccgcccctaa gtcgggaagg ttccttgcgg ttcgcggcgt     5520

gccggacgtg acaaacggaa gccgcacgtc tcactagtac cctcgcagac ggacagcgcc     5580

agggagcaat ggcagcgcgc cgaccgcgat gggctgtggc caatagcggc tgctcagcag     5640

ggcgcgccga gagcagcggc cgggaagggg cggtgcggga ggcggggtgt ggggcggtag     5700

tgtgggccct gttcctgccc gcgcggtgtt ccgcattctg caagcctccg gagcgcacgt     5760

cggcagtcgg ctccctcgtt gaccgaatca ccgacctctc tccccagggg gatcatcgaa     5820

ttaccatgtc tagactggac aagagcaaag tcataaactc tgctctggaa ttactcaatg     5880

gagtcggtat cgaaggcctg acgacaagga aactcgctca aaagctggga gttgagcagc     5940

ctaccctgta ctggcacgtg aagaacaagc gggccctgct cgatgccctg ccaatcgaga     6000

tgctggacag gcatcatacc cactcctgcc ccctggaagg cgagtcatgg caagactttc     6060

tgcggaacaa cgccaagtca taccgctgtg ctctcctctc acatcgcgac ggggctaaag     6120

tgcatctcgg cacccgccca acagagaaac agtacgaaac cctggaaaat cagctcgcgt     6180

tcctgtgtca gcaaggcttc tccctggaga acgcactgta cgctctgtcc gccgtgggcc     6240

actttacact gggctgcgta ttggaggaac aggagcatca agtagcaaaa gaggaaagag     6300

agacacctac caccgattct atgcccccac ttctgaaaca agcaattgag ctgttcgacc     6360

ggcagggagc cgaacctgcc ttccttttcg gcctggaact aatcatatgt ggcctggaga     6420

aacagctaaa gtgcgaaagc ggcgggccga ccgacgccct tgacgatttt gacttagaca     6480

tgctcccagc cgatgccctt gacgactttg accttgatat gctgcctgct gacgctcttg     6540

acgattttga ccttgacatg ctccccgggt aaacgcgcga atgtgtgtca gttagggtgt     6600

ggaaagtccc caggctcccc agcaggcaga agtatgcaaa gcatgcatct caattagtca     6660

gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat     6720

ctcaattagt cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg     6780

cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc     6840

gaggccgcct cggcctctga gctattccag aagtagtgag gaggcttttt tggaggccta     6900

ggcttttgca aaacgcgacc atgaccgagt acaagcccac ggtgcgcctc gccacccgcg     6960

acgacgtccc ccgggccgta cgcaccctcg ccgccgcgtt cgccgactac cccgccacgc     7020

gccacaccgt cgacccggac cgccacatcg agcgggtcac cgagctgcaa gaactcttcc     7080

tcacgcgcgt cgggctcgac atcggcaagg tgtgggtcgc ggacgacggc gccgcggtgg     7140

cggtctggac cacgccggag agcgtcgaag cgggggcggt gttcgccgag atcggcccgc     7200

gcatggccga gttgagcggt tcccggctgg ccgcgcagca acagatggaa ggcctcctgg     7260

cgccgcaccg gcccaaggag cccgcgtggt tcctggccac cgtcggcgtc tcgcccgacc     7320

accagggcaa gggtctgggc agcgccgtcg tgctccccgg agtggaggcg gccgagcgcg     7380

ccggggtgcc cgccttcctg gagacctccg cgccccgcaa cctccccttc tacgagcggc     7440

tcggcttcac cgtcaccgcc gacgtcgagg tgcccgaagg accgcgcacc tggtgcatga     7500

cccgcaagcc cggtgcctga acgcgtctgg aacaatcaac ctctggatta caaaatttgt     7560

gaaagattga ctggtattct taactatgtt gctcctttta cgctatgtgg atacgctgct     7620

ttaatgcctt tgtatcatgc tattgcttcc cgtatggctt tcattttctc ctccttgtat     7680

aaatcctggt tgctgtctct ttatgaggag ttgtggcccg ttgtcaggca acgtggcgtg     7740

gtgtgcactg tgtttgctga cgcaaccccc actggttggg gcattgccac cacctgtcag     7800

ctcctttccg ggactttcgc tttccccctc cctattgcca cggcggaact catcgccgcc     7860

tgccttgccc gctgctggac aggggctcgg ctgttgggca ctgacaattc cgtggtgttg     7920

tcggggaagc tgacgtcctt tccatggctg ctcgcctgtg ttgccacctg gattctgcgc     7980

gggacgtcct tctgctacgt cccttcggcc ctcaatccag cggaccttcc ttcccgcggc     8040

ctgctgccgg ctctgcggcc tcttccgcgt cttcgccttc gccctcagac gagtcggatc     8100

tccctttggg ccgcctcccc gcctggaatt aattctgcag tcgagaccta gaaaaacatg     8160

gagcaatcac aagtagcaat acagcagcta ccaatgctga ttgtgcctgg ctagaagcac     8220

aagaggagga ggaggtgggt ttttccagtc acacctcagg tacctttaag accaatgact     8280

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa agaggggact ggaagggcta     8340

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac     8400

ttccctgatt agcagaacta cacaccaggg ccaggggtca gatatccact gacctttgga     8460

tggtgctaca agctagtacc agttgagcca gataaggtag aagaggccaa taaaggagag     8520

aacaccagct tgttacaccc tgtgagcctg catgggatgg atgacccgga gagagaagtg     8580

ttagagtgga ggtttgacag ccgcctagca tttcatcacg tggcccgaga gctgcatccg     8640

gagtacttca agaactgctg atatcgagct tgctacaagg gactttccgc tggggacttt     8700

ccagggaggc gtggcctggg cgggactggg gagtggcgag ccctcagatc ctgcatataa     8760

gcagctgctt tttgcctgta ctgggtctct ctggttagac cagatctgag cctgggagct     8820

ctctggctaa ctagggaacc cactgcttaa gcctcaataa agcttgcctt gagtgcttca     8880

agtagtgtgt gcccgtctgt tgtgtgactc tggtaactag agatccctca gaccctttta     8940

gtcagtgtgg aaaatctcta gcagtagtag ttcatgtcat cttattattc agtatttata     9000

acttgcaaag aaatgaatat cagagagtga gaggccttga cattgctagc gttttaccgt     9060

cgacctctag ctagagcttg gcgtaatcat ggtcatagct gtttcctgtg tgaaattgtt     9120

atccgctcac aattccacac aacatacgag ccggaagcat aaagtgtaaa gcctggggtg     9180

cctaatgagt gagctaactc acattaattg cgttgcgctc actgcccgct ttccagtcgg     9240

gaaacctgtc gtgccagctg cattaatgaa tcggccaacg cgcggggaga ggcggtttgc     9300

gtattgggcg ctcttccgct tcctcgctca ctgactcgct gcgctcggtc gttcggctgc     9360

ggcgagcggt atcagctcac tcaaaggcgg taatacggtt atccacagaa tcaggggata     9420

acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg     9480

cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa aatcgacgct     9540

caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt ccccctggaa     9600

gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg tccgcctttc     9660

tcccttcggg aagcgtggcg ctttctcata gctcacgctg taggtatctc agttcggtgt     9720

aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg     9780

ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta tcgccactgg     9840

cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct acagagttct     9900

tgaagtggtg gcctaactac ggctacacta gaagaacagt atttggtatc tgcgctctgc     9960

tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa caaaccaccg    10020

ctggtagcgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag    10080

aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag    10140

ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat    10200

gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaatgct    10260

taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata gttgcctgac    10320

tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc agtgctgcaa    10380

tgataccgcg agacccacgc tcaccggctc cagatttatc agcaataaac cagccagccg    10440

gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag tctattaatt    10500

gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac gttgttgcca    10560

ttgctacagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc agctccggtt    10620

cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg gttagctcct    10680

tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc atggttatgg    10740

cagcactgca taattctctt actgtcatgc catccgtaag atgcttttct gtgactggtg    10800

agtactcaac caagtcattc tgagaatagt gtatgcggcg accgagttgc tcttgcccgg    10860

cgtcaatacg ggataatacc gcgccacata gcagaacttt aaaagtgctc atcattggaa    10920

aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc agttcgatgt    10980

aacccactcg tgcacccaac tgatcttcag catcttttac tttcaccagc gtttctgggt    11040

gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt    11100

gaatactcat actcttcctt tttcaatatt attgaagcat ttatcagggt tattgtctca    11160

tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt ccgcgcacat    11220

ttccccgaaa agtgccacct gacgtcgacg gatcgggaga tcaacttgtt tattgcagct    11280

tataatggtt acaaataaag caatagcatc acaaatttca caaataaagc atttttttca    11340

ctgcattcta gttgtggttt gtccaaactc atcaatgtat cttatcatgt ctggatcaac    11400

tggataactc aagctaacca aaatcatccc aaacttccca ccccataccc tattaccact    11460

gccaattacc tagtggtttc atttactcta aacctgtgat tcctctgaat tattttcatt    11520

ttaaagaaat tgtatttgtt aaatatgtac tacaaactta gtagttttta aagaaattgt    11580

atttgttaaa tatgtactac aaacttagta gt                                  11612


