                               SEQUENCE LISTING

<110> KUMQUAT BIOSCIENCES INC.
 
<120> HETEROCYCLES AND USES THEREOF

<130> 56690-718.601

<140> PCT/US2021/055086
<141> 2021-10-14

<150> 63/092,490
<151> 2020-10-15

<160> 6     

<170> PatentIn version 3.5

<210> 1
<211> 188
<212> PRT
<213> Homo sapiens

<400> 1
Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Lys Thr Lys Cys Val Ile Met 
            180                 185             


<210> 2

<400> 2
000


<210> 3
<211> 1333
<212> PRT
<213> Homo sapiens

<400> 3
Met Gln Ala Gln Gln Leu Pro Tyr Glu Phe Phe Ser Glu Glu Asn Ala 
1               5                   10                  15      


Pro Lys Trp Arg Gly Leu Leu Val Pro Ala Leu Lys Lys Val Gln Gly 
            20                  25                  30          


Gln Val His Pro Thr Leu Glu Ser Asn Asp Asp Ala Leu Gln Tyr Val 
        35                  40                  45              


Glu Glu Leu Ile Leu Gln Leu Leu Asn Met Leu Cys Gln Ala Gln Pro 
    50                  55                  60                  


Arg Ser Ala Ser Asp Val Glu Glu Arg Val Gln Lys Ser Phe Pro His 
65                  70                  75                  80  


Pro Ile Asp Lys Trp Ala Ile Ala Asp Ala Gln Ser Ala Ile Glu Lys 
                85                  90                  95      


Arg Lys Arg Arg Asn Pro Leu Ser Leu Pro Val Glu Lys Ile His Pro 
            100                 105                 110         


Leu Leu Lys Glu Val Leu Gly Tyr Lys Ile Asp His Gln Val Ser Val 
        115                 120                 125             


Tyr Ile Val Ala Val Leu Glu Tyr Ile Ser Ala Asp Ile Leu Lys Leu 
    130                 135                 140                 


Val Gly Asn Tyr Val Arg Asn Ile Arg His Tyr Glu Ile Thr Lys Gln 
145                 150                 155                 160 


Asp Ile Lys Val Ala Met Cys Ala Asp Lys Val Leu Met Asp Met Phe 
                165                 170                 175     


His Gln Asp Val Glu Asp Ile Asn Ile Leu Ser Leu Thr Asp Glu Glu 
            180                 185                 190         


Pro Ser Thr Ser Gly Glu Gln Thr Tyr Tyr Asp Leu Val Lys Ala Phe 
        195                 200                 205             


Met Ala Glu Ile Arg Gln Tyr Ile Arg Glu Leu Asn Leu Ile Ile Lys 
    210                 215                 220                 


Val Phe Arg Glu Pro Phe Val Ser Asn Ser Lys Leu Phe Ser Ala Asn 
225                 230                 235                 240 


Asp Val Glu Asn Ile Phe Ser Arg Ile Val Asp Ile His Glu Leu Ser 
                245                 250                 255     


Val Lys Leu Leu Gly His Ile Glu Asp Thr Val Glu Met Thr Asp Glu 
            260                 265                 270         


Gly Ser Pro His Pro Leu Val Gly Ser Cys Phe Glu Asp Leu Ala Glu 
        275                 280                 285             


Glu Leu Ala Phe Asp Pro Tyr Glu Ser Tyr Ala Arg Asp Ile Leu Arg 
    290                 295                 300                 


Pro Gly Phe His Asp Arg Phe Leu Ser Gln Leu Ser Lys Pro Gly Ala 
305                 310                 315                 320 


Ala Leu Tyr Leu Gln Ser Ile Gly Glu Gly Phe Lys Glu Ala Val Gln 
                325                 330                 335     


Tyr Val Leu Pro Arg Leu Leu Leu Ala Pro Val Tyr His Cys Leu His 
            340                 345                 350         


Tyr Phe Glu Leu Leu Lys Gln Leu Glu Glu Lys Ser Glu Asp Gln Glu 
        355                 360                 365             


Asp Lys Glu Cys Leu Lys Gln Ala Ile Thr Ala Leu Leu Asn Val Gln 
    370                 375                 380                 


Ser Gly Met Glu Lys Ile Cys Ser Lys Ser Leu Ala Lys Arg Arg Leu 
385                 390                 395                 400 


Ser Glu Ser Ala Cys Arg Phe Tyr Ser Gln Gln Met Lys Gly Lys Gln 
                405                 410                 415     


Leu Ala Ile Lys Lys Met Asn Glu Ile Gln Lys Asn Ile Asp Gly Trp 
            420                 425                 430         


Glu Gly Lys Asp Ile Gly Gln Cys Cys Asn Glu Phe Ile Met Glu Gly 
        435                 440                 445             


Thr Leu Thr Arg Val Gly Ala Lys His Glu Arg His Ile Phe Leu Phe 
    450                 455                 460                 


Asp Gly Leu Met Ile Cys Cys Lys Ser Asn His Gly Gln Pro Arg Leu 
465                 470                 475                 480 


Pro Gly Ala Ser Asn Ala Glu Tyr Arg Leu Lys Glu Lys Phe Phe Met 
                485                 490                 495     


Arg Lys Val Gln Ile Asn Asp Lys Asp Asp Thr Asn Glu Tyr Lys His 
            500                 505                 510         


Ala Phe Glu Ile Ile Leu Lys Asp Glu Asn Ser Val Ile Phe Ser Ala 
        515                 520                 525             


Lys Ser Ala Glu Glu Lys Asn Asn Trp Met Ala Ala Leu Ile Ser Leu 
    530                 535                 540                 


Gln Tyr Arg Ser Thr Leu Glu Arg Met Leu Asp Val Thr Met Leu Gln 
545                 550                 555                 560 


Glu Glu Lys Glu Glu Gln Met Arg Leu Pro Ser Ala Asp Val Tyr Arg 
                565                 570                 575     


Phe Ala Glu Pro Asp Ser Glu Glu Asn Ile Ile Phe Glu Glu Asn Met 
            580                 585                 590         


Gln Pro Lys Ala Gly Ile Pro Ile Ile Lys Ala Gly Thr Val Ile Lys 
        595                 600                 605             


Leu Ile Glu Arg Leu Thr Tyr His Met Tyr Ala Asp Pro Asn Phe Val 
    610                 615                 620                 


Arg Thr Phe Leu Thr Thr Tyr Arg Ser Phe Cys Lys Pro Gln Glu Leu 
625                 630                 635                 640 


Leu Ser Leu Ile Ile Glu Arg Phe Glu Ile Pro Glu Pro Glu Pro Thr 
                645                 650                 655     


Glu Ala Asp Arg Ile Ala Ile Glu Asn Gly Asp Gln Pro Leu Ser Ala 
            660                 665                 670         


Glu Leu Lys Arg Phe Arg Lys Glu Tyr Ile Gln Pro Val Gln Leu Arg 
        675                 680                 685             


Val Leu Asn Val Cys Arg His Trp Val Glu His His Phe Tyr Asp Phe 
    690                 695                 700                 


Glu Arg Asp Ala Tyr Leu Leu Gln Arg Met Glu Glu Phe Ile Gly Thr 
705                 710                 715                 720 


Val Arg Gly Lys Ala Met Lys Lys Trp Val Glu Ser Ile Thr Lys Ile 
                725                 730                 735     


Ile Gln Arg Lys Lys Ile Ala Arg Asp Asn Gly Pro Gly His Asn Ile 
            740                 745                 750         


Thr Phe Gln Ser Ser Pro Pro Thr Val Glu Trp His Ile Ser Arg Pro 
        755                 760                 765             


Gly His Ile Glu Thr Phe Asp Leu Leu Thr Leu His Pro Ile Glu Ile 
    770                 775                 780                 


Ala Arg Gln Leu Thr Leu Leu Glu Ser Asp Leu Tyr Arg Ala Val Gln 
785                 790                 795                 800 


Pro Ser Glu Leu Val Gly Ser Val Trp Thr Lys Glu Asp Lys Glu Ile 
                805                 810                 815     


Asn Ser Pro Asn Leu Leu Lys Met Ile Arg His Thr Thr Asn Leu Thr 
            820                 825                 830         


Leu Trp Phe Glu Lys Cys Ile Val Glu Thr Glu Asn Leu Glu Glu Arg 
        835                 840                 845             


Val Ala Val Val Ser Arg Ile Ile Glu Ile Leu Gln Val Phe Gln Glu 
    850                 855                 860                 


Leu Asn Asn Phe Asn Gly Val Leu Glu Val Val Ser Ala Met Asn Ser 
865                 870                 875                 880 


Ser Pro Val Tyr Arg Leu Asp His Thr Phe Glu Gln Ile Pro Ser Arg 
                885                 890                 895     


Gln Lys Lys Ile Leu Glu Glu Ala His Glu Leu Ser Glu Asp His Tyr 
            900                 905                 910         


Lys Lys Tyr Leu Ala Lys Leu Arg Ser Ile Asn Pro Pro Cys Val Pro 
        915                 920                 925             


Phe Phe Gly Ile Tyr Leu Thr Asn Ile Leu Lys Thr Glu Glu Gly Asn 
    930                 935                 940                 


Pro Glu Val Leu Lys Arg His Gly Lys Glu Leu Ile Asn Phe Ser Lys 
945                 950                 955                 960 


Arg Arg Lys Val Ala Glu Ile Thr Gly Glu Ile Gln Gln Tyr Gln Asn 
                965                 970                 975     


Gln Pro Tyr Cys Leu Arg Val Glu Ser Asp Ile Lys Arg Phe Phe Glu 
            980                 985                 990         


Asn Leu Asn Pro Met Gly Asn Ser  Met Glu Lys Glu Phe  Thr Asp Tyr 
        995                 1000                 1005             


Leu Phe  Asn Lys Ser Leu Glu  Ile Glu Pro Arg Asn  Pro Lys Pro 
    1010                 1015                 1020             


Leu Pro  Arg Phe Pro Lys Lys  Tyr Ser Tyr Pro Leu  Lys Ser Pro 
    1025                 1030                 1035             


Gly Val  Arg Pro Ser Asn Pro  Arg Pro Gly Thr Met  Arg His Pro 
    1040                 1045                 1050             


Thr Pro  Leu Gln Gln Glu Pro  Arg Lys Ile Ser Tyr  Ser Arg Ile 
    1055                 1060                 1065             


Pro Glu  Ser Glu Thr Glu Ser  Thr Ala Ser Ala Pro  Asn Ser Pro 
    1070                 1075                 1080             


Arg Thr  Pro Leu Thr Pro Pro  Pro Ala Ser Gly Ala  Ser Ser Thr 
    1085                 1090                 1095             


Thr Asp  Val Cys Ser Val Phe  Asp Ser Asp His Ser  Ser Pro Phe 
    1100                 1105                 1110             


His Ser  Ser Asn Asp Thr Val  Phe Ile Gln Val Thr  Leu Pro His 
    1115                 1120                 1125             


Gly Pro  Arg Ser Ala Ser Val  Ser Ser Ile Ser Leu  Thr Lys Gly 
    1130                 1135                 1140             


Thr Asp  Glu Val Pro Val Pro  Pro Pro Val Pro Pro  Arg Arg Arg 
    1145                 1150                 1155             


Pro Glu  Ser Ala Pro Ala Glu  Ser Ser Pro Ser Lys  Ile Met Ser 
    1160                 1165                 1170             


Lys His  Leu Asp Ser Pro Pro  Ala Ile Pro Pro Arg  Gln Pro Thr 
    1175                 1180                 1185             


Ser Lys  Ala Tyr Ser Pro Arg  Tyr Ser Ile Ser Asp  Arg Thr Ser 
    1190                 1195                 1200             


Ile Ser  Asp Pro Pro Glu Ser  Pro Pro Leu Leu Pro  Pro Arg Glu 
    1205                 1210                 1215             


Pro Val  Arg Thr Pro Asp Val  Phe Ser Ser Ser Pro  Leu His Leu 
    1220                 1225                 1230             


Gln Pro  Pro Pro Leu Gly Lys  Lys Ser Asp His Gly  Asn Ala Phe 
    1235                 1240                 1245             


Phe Pro  Asn Ser Pro Ser Pro  Phe Thr Pro Pro Pro  Pro Gln Thr 
    1250                 1255                 1260             


Pro Ser  Pro His Gly Thr Arg  Arg His Leu Pro Ser  Pro Pro Leu 
    1265                 1270                 1275             


Thr Gln  Glu Val Asp Leu His  Ser Ile Ala Gly Pro  Pro Val Pro 
    1280                 1285                 1290             


Pro Arg  Gln Ser Thr Ser Gln  His Ile Pro Lys Leu  Pro Pro Lys 
    1295                 1300                 1305             


Thr Tyr  Lys Arg Glu His Thr  His Pro Ser Met His  Arg Asp Gly 
    1310                 1315                 1320             


Pro Pro  Leu Leu Glu Asn Ala  His Ser Ser 
    1325                 1330             


<210> 4

<400> 4
000


<210> 5
<211> 1332
<212> PRT
<213> Homo sapiens

<400> 5
Met Gln Gln Ala Pro Gln Pro Tyr Glu Phe Phe Ser Glu Glu Asn Ser 
1               5                   10                  15      


Pro Lys Trp Arg Gly Leu Leu Val Ser Ala Leu Arg Lys Val Gln Glu 
            20                  25                  30          


Gln Val His Pro Thr Leu Ser Ala Asn Glu Glu Ser Leu Tyr Tyr Ile 
        35                  40                  45              


Glu Glu Leu Ile Phe Gln Leu Leu Asn Lys Leu Cys Met Ala Gln Pro 
    50                  55                  60                  


Arg Thr Val Gln Asp Val Glu Glu Arg Val Gln Lys Thr Phe Pro His 
65                  70                  75                  80  


Pro Ile Asp Lys Trp Ala Ile Ala Asp Ala Gln Ser Ala Ile Glu Lys 
                85                  90                  95      


Arg Lys Arg Arg Asn Pro Leu Leu Leu Pro Val Asp Lys Ile His Pro 
            100                 105                 110         


Ser Leu Lys Glu Val Leu Gly Tyr Lys Val Asp Tyr His Val Ser Leu 
        115                 120                 125             


Tyr Ile Val Ala Val Leu Glu Tyr Ile Ser Ala Asp Ile Leu Lys Leu 
    130                 135                 140                 


Ala Gly Asn Tyr Val Phe Asn Ile Arg His Tyr Glu Ile Ser Gln Gln 
145                 150                 155                 160 


Asp Ile Lys Val Ser Met Cys Ala Asp Lys Val Leu Met Asp Met Phe 
                165                 170                 175     


Asp Gln Asp Asp Ile Gly Leu Val Ser Leu Cys Glu Asp Glu Pro Ser 
            180                 185                 190         


Ser Ser Gly Glu Leu Asn Tyr Tyr Asp Leu Val Arg Thr Glu Ile Ala 
        195                 200                 205             


Glu Glu Arg Gln Tyr Leu Arg Glu Leu Asn Met Ile Ile Lys Val Phe 
    210                 215                 220                 


Arg Glu Ala Phe Leu Ser Asp Arg Lys Leu Phe Lys Pro Ser Asp Ile 
225                 230                 235                 240 


Glu Lys Ile Phe Ser Asn Ile Ser Asp Ile His Glu Leu Thr Val Lys 
                245                 250                 255     


Leu Leu Gly Leu Ile Glu Asp Thr Val Glu Met Thr Asp Glu Ser Ser 
            260                 265                 270         


Pro His Pro Leu Ala Gly Ser Cys Phe Glu Asp Leu Ala Glu Glu Gln 
        275                 280                 285             


Ala Phe Asp Pro Tyr Glu Thr Leu Ser Gln Asp Ile Leu Ser Pro Glu 
    290                 295                 300                 


Phe His Glu His Phe Asn Lys Leu Met Ala Arg Pro Ala Val Ala Leu 
305                 310                 315                 320 


His Phe Gln Ser Ile Ala Asp Gly Phe Lys Glu Ala Val Arg Tyr Val 
                325                 330                 335     


Leu Pro Arg Leu Met Leu Val Pro Val Tyr His Cys Trp His Tyr Phe 
            340                 345                 350         


Glu Leu Leu Lys Gln Leu Lys Ala Cys Ser Glu Glu Gln Glu Asp Arg 
        355                 360                 365             


Glu Cys Leu Asn Gln Ala Ile Thr Ala Leu Met Asn Leu Gln Gly Ser 
    370                 375                 380                 


Met Asp Arg Ile Tyr Lys Gln Tyr Ser Pro Arg Arg Arg Pro Gly Asp 
385                 390                 395                 400 


Pro Val Cys Pro Phe Tyr Ser His Gln Leu Arg Ser Lys His Leu Ala 
                405                 410                 415     


Ile Lys Lys Met Asn Glu Ile Gln Lys Asn Ile Asp Gly Trp Glu Gly 
            420                 425                 430         


Lys Asp Ile Gly Gln Cys Cys Asn Glu Phe Ile Met Glu Gly Pro Leu 
        435                 440                 445             


Thr Arg Ile Gly Ala Lys His Glu Arg His Ile Phe Leu Phe Asp Gly 
    450                 455                 460                 


Leu Met Ile Ser Cys Lys Pro Asn His Gly Gln Thr Arg Leu Pro Gly 
465                 470                 475                 480 


Tyr Ser Ser Ala Glu Tyr Arg Leu Lys Glu Lys Phe Val Met Arg Lys 
                485                 490                 495     


Ile Gln Ile Cys Asp Lys Glu Asp Thr Cys Glu His Lys His Ala Phe 
            500                 505                 510         


Glu Leu Val Ser Lys Asp Glu Asn Ser Ile Ile Phe Ala Ala Lys Ser 
        515                 520                 525             


Ala Glu Glu Lys Asn Asn Trp Met Ala Ala Leu Ile Ser Leu His Tyr 
    530                 535                 540                 


Arg Ser Thr Leu Asp Arg Met Leu Asp Ser Val Leu Leu Lys Glu Glu 
545                 550                 555                 560 


Asn Glu Gln Pro Leu Arg Leu Pro Ser Pro Glu Val Tyr Arg Phe Val 
                565                 570                 575     


Val Lys Asp Ser Glu Glu Asn Ile Val Phe Glu Asp Asn Leu Gln Ser 
            580                 585                 590         


Arg Ser Gly Ile Pro Ile Ile Lys Gly Gly Thr Val Val Lys Leu Ile 
        595                 600                 605             


Glu Arg Leu Thr Tyr His Met Tyr Ala Asp Pro Asn Phe Val Arg Thr 
    610                 615                 620                 


Phe Leu Thr Thr Tyr Arg Ser Phe Cys Lys Pro Gln Glu Leu Leu Ser 
625                 630                 635                 640 


Leu Leu Ile Glu Arg Phe Glu Ile Pro Glu Pro Glu Pro Thr Asp Ala 
                645                 650                 655     


Asp Lys Leu Ala Ile Glu Lys Gly Glu Gln Pro Ile Ser Ala Asp Leu 
            660                 665                 670         


Lys Arg Phe Arg Lys Glu Tyr Val Gln Pro Val Gln Leu Arg Ile Leu 
        675                 680                 685             


Asn Val Phe Arg His Trp Val Glu His His Phe Tyr Asp Phe Glu Arg 
    690                 695                 700                 


Asp Leu Glu Leu Leu Glu Arg Leu Glu Ser Phe Ile Ser Ser Val Arg 
705                 710                 715                 720 


Gly Lys Ala Met Lys Lys Trp Val Glu Ser Ile Ala Lys Ile Ile Arg 
                725                 730                 735     


Arg Lys Lys Gln Ala Gln Ala Asn Gly Val Ser His Asn Ile Thr Phe 
            740                 745                 750         


Glu Ser Pro Pro Pro Pro Ile Glu Trp His Ile Ser Lys Pro Gly Gln 
        755                 760                 765             


Phe Glu Thr Phe Asp Leu Met Thr Leu His Pro Ile Glu Ile Ala Arg 
    770                 775                 780                 


Gln Leu Thr Leu Leu Glu Ser Asp Leu Tyr Arg Lys Val Gln Pro Ser 
785                 790                 795                 800 


Glu Leu Val Gly Ser Val Trp Thr Lys Glu Asp Lys Glu Ile Asn Ser 
                805                 810                 815     


Pro Asn Leu Leu Lys Met Ile Arg His Thr Thr Asn Leu Thr Leu Trp 
            820                 825                 830         


Phe Glu Lys Cys Ile Val Glu Ala Glu Asn Phe Glu Glu Arg Val Ala 
        835                 840                 845             


Val Leu Ser Arg Ile Ile Glu Ile Leu Gln Val Phe Gln Asp Leu Asn 
    850                 855                 860                 


Asn Phe Asn Gly Val Leu Glu Ile Val Ser Ala Val Asn Ser Val Ser 
865                 870                 875                 880 


Val Tyr Arg Leu Asp His Thr Phe Glu Ala Leu Gln Glu Arg Lys Arg 
                885                 890                 895     


Lys Ile Leu Asp Glu Ala Val Glu Leu Ser Gln Asp His Phe Lys Lys 
            900                 905                 910         


Tyr Leu Val Lys Leu Lys Ser Ile Asn Pro Pro Cys Val Pro Phe Phe 
        915                 920                 925             


Gly Ile Tyr Leu Thr Asn Ile Leu Lys Thr Glu Glu Gly Asn Asn Asp 
    930                 935                 940                 


Phe Leu Lys Lys Lys Gly Lys Asp Leu Ile Asn Phe Ser Lys Arg Arg 
945                 950                 955                 960 


Lys Val Ala Glu Ile Thr Gly Glu Ile Gln Gln Tyr Gln Asn Gln Pro 
                965                 970                 975     


Tyr Cys Leu Arg Ile Glu Pro Asp Met Arg Arg Phe Phe Glu Asn Leu 
            980                 985                 990         


Asn Pro Met Gly Ser Ala Ser Glu  Lys Glu Phe Thr Asp  Tyr Leu Phe 
        995                 1000                 1005             


Asn Lys  Ser Leu Glu Ile Glu  Pro Arg Asn Cys Lys  Gln Pro Pro 
    1010                 1015                 1020             


Arg Phe  Pro Arg Lys Ser Thr  Phe Ser Leu Lys Ser  Pro Gly Ile 
    1025                 1030                 1035             


Arg Pro  Asn Thr Gly Arg His  Gly Ser Thr Ser Gly  Thr Leu Arg 
    1040                 1045                 1050             


Gly His  Pro Thr Pro Leu Glu  Arg Glu Pro Cys Lys  Ile Ser Phe 
    1055                 1060                 1065             


Ser Arg  Ile Ala Glu Thr Glu  Leu Glu Ser Thr Val  Ser Ala Pro 
    1070                 1075                 1080             


Thr Ser  Pro Asn Thr Pro Ser  Thr Pro Pro Val Ser  Ala Ser Ser 
    1085                 1090                 1095             


Asp Leu  Ser Val Phe Leu Asp  Val Asp Leu Asn Ser  Ser Cys Gly 
    1100                 1105                 1110             


Ser Asn  Ser Ile Phe Ala Pro  Val Leu Leu Pro His  Ser Lys Ser 
    1115                 1120                 1125             


Phe Phe  Ser Ser Cys Gly Ser  Leu His Lys Leu Ser  Glu Glu Pro 
    1130                 1135                 1140             


Leu Ile  Pro Pro Pro Leu Pro  Pro Arg Lys Lys Phe  Asp His Asp 
    1145                 1150                 1155             


Ala Ser  Asn Ser Lys Gly Asn  Met Lys Ser Asp Asp  Asp Pro Pro 
    1160                 1165                 1170             


Ala Ile  Pro Pro Arg Gln Pro  Pro Pro Pro Lys Val  Lys Pro Arg 
    1175                 1180                 1185             


Val Pro  Val Pro Thr Gly Ala  Phe Asp Gly Pro Leu  His Ser Pro 
    1190                 1195                 1200             


Pro Pro  Pro Pro Pro Arg Asp  Pro Leu Pro Asp Thr  Pro Pro Pro 
    1205                 1210                 1215             


Val Pro  Leu Arg Pro Pro Glu  His Phe Ile Asn Cys  Pro Phe Asn 
    1220                 1225                 1230             


Leu Gln  Pro Pro Pro Leu Gly  His Leu His Arg Asp  Ser Asp Trp 
    1235                 1240                 1245             


Leu Arg  Asp Ile Ser Thr Cys  Pro Asn Ser Pro Ser  Thr Pro Pro 
    1250                 1255                 1260             


Ser Thr  Pro Ser Pro Arg Val  Pro Arg Arg Cys Tyr  Val Leu Ser 
    1265                 1270                 1275             


Ser Ser  Gln Asn Asn Leu Ala  His Pro Pro Ala Pro  Pro Val Pro 
    1280                 1285                 1290             


Pro Arg  Gln Asn Ser Ser Pro  His Leu Pro Lys Leu  Pro Pro Lys 
    1295                 1300                 1305             


Thr Tyr  Lys Arg Glu Leu Ser  His Pro Pro Leu Tyr  Arg Leu Pro 
    1310                 1315                 1320             


Leu Leu  Glu Asn Ala Glu Thr  Pro Gln 
    1325                 1330         


<210> 6
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      10xHis tag

<400> 6
His His His His His His His His His His 
1               5                   10  


