                         SEQUENCE LISTING

<110>  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
 
<120>  ANTI-CANCER INHIBITORY ANTIBODIES

<130>  009062-8439.WO00

<140>  PCT/US2021/055055
<141>  2021-10-14

<150>  US 63/092,384
<151>  2020-10-15

<160>  35    

<170>  PatentIn version 3.5

<210>  1
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-TSPAN3 M1 clone heavy chain variable region DNA 
       sequence

<400>  1
caggtccaac tgcagcagcc tggggctgag ctggtaaagc ctggggcttc agtgaagttg       60

tcctgcaagg cttctggcta cactttcacc agctactgga tgcactgggt gaagcagagg      120

cctggacaag gccttgagtg gattggaatg attcatccta atagtggtag tcctaactac      180

aatgagaggt tcaagagcaa ggccacactg actgtagaca aatcctccag cacagcctac      240

atgcaactca gcagcctgac atctgaggac tctgcggtct atttctgtgc aagatggggt      300

gatggttacc acaggtactt cgatgtctgg ggcacaggga ccacggtcac cgtctcctca      360


<210>  2
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-TSPAN3 M1 clone heavy chain variable region amino
       acid sequence

<400>  2

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile His Pro Asn Ser Gly Ser Pro Asn Tyr Asn Glu Arg Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Trp Gly Asp Gly Tyr His Arg Tyr Phe Asp Val Trp Gly Thr 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  3
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-TSPAN3 M1 clone heavy chain CDR1 amino acid 
       sequence

<400>  3

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-TSPAN3 M1 clone heavy chain CDR2 amino acid 
       sequence

<400>  4

Ile His Pro Asn Ser Gly Ser Pro 
1               5               


<210>  5
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-TSPAN3 M1 clone heavy chain CDR3 amino acid 
       sequence

<400>  5

Ala Arg Trp Gly Asp Gly Tyr His Arg Tyr Phe Asp Val 
1               5                   10              


<210>  6
<211>  350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-TSPAN3 M3 clone heavy chain variable region DNA 
       sequence

<400>  6
cagatccagt tggtacagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctgggta taccttcaca acctatggaa tgagctgggt gaaacaggct      120

ccaggaaagg gtttaaagtg gatgggctgg ataaacacct actctggagt gccaacatat      180

gctgatgact tcaagggacg gtttgccttc tctttggaaa cctctgccag cactgcctat      240

ttgcagatca acaacctcaa aaatgaggac acggctacat atttctgtgc aagatcacat      300

tatagtaact tttatgctat ggactactgg ggtcaagaac ctcagtcacc                 350


<210>  7
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-TSPAN3 M3 clone heavy chain variable region amino
       acid sequence

<400>  7

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser His Tyr Ser Asn Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Glu Pro Gln Ser Pro 
        115         


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-TSPAN3 M3 clone heavy chain CDR1 amino acid 
       sequence

<400>  8

Gly Tyr Thr Phe Thr Thr Tyr Gly 
1               5               


<210>  9
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-TSPAN3 M3 clone heavy chain CDR2 amino acid 
       sequence

<400>  9

Ile Asn Thr Tyr Ser Gly Val Pro 
1               5               


<210>  10
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-TSPAN3 M3 clone heavy chain CDR3 amino acid 
       sequence

<400>  10

Ala Arg Ser His Tyr Ser Asn Phe Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  11
<211>  343
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-TSPAN3 M5/M6 clone heavy chain variable region 
       DNA sequence

<400>  11
gaggtccagc tgcaacagtc tggacctgag ctggtgaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggata cacattcact gacttctaca tgcattgggt gaagcagagt      120

catggaagga gccttgagtg gattggatat atttaccctc acaatggttt tactaagtac      180

aaccagagtt tcatgggcaa ggccacattg actgtgaaca agtcctccaa cacagcctac      240

atggagctcc gcagcctgac atcggaggat tctgcagtct attactgtgc aagacgttac      300

ggggactact ggggtcaagg aatctcagtc accgtctcct cag                        343


<210>  12
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-TSPAN3 M5/M6 clone heavy chain variable region 
       amino acid sequence

<400>  12

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Phe 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Ser His Gly Arg Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro His Asn Gly Phe Thr Lys Tyr Asn Gln Ser Phe 
    50                  55                  60                  


Met Gly Lys Ala Thr Leu Thr Val Asn Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Tyr Gly Asp Tyr Trp Gly Gln Gly Ile Ser Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-TSPAN3 M5/M6 clone heavy chain CDR1 amino acid 
       sequence

<400>  13

Gly Tyr Thr Phe Thr Asp Phe Tyr 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-TSPAN3 M5/M6 clone heavy chain CDR2 amino acid 
       sequence

<400>  14

Ile Tyr Pro His Asn Gly Phe Thr 
1               5               


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-TSPAN3 M5/M6 clone heavy chain CDR3 amino acid 
       sequence

<400>  15

Ala Arg Arg Tyr Gly Asp Tyr 
1               5           


<210>  16
<211>  325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-TSPAN3 M1 clone light chain variable region DNA 
       sequence

<400>  16
gacatccaga tgactcagtc tccagcctcc ctatctgcat ctgtgggaga aactgtcacc       60

atcacatgtc gagcaagtgg gaatattcac aattatttag catggtatca gcagaaacag      120

ggaaaatctc ctcagctcct ggtctataat gcaaaaacct tagcagatgg tgtgccatca      180

aggttcagtg gcagtggatc aggaacacaa tattctctca agatcaacag cctgcagcct      240

gaagattttg ggagttatta ctgtcaacat ttttggagta ctcctccgta cacgttcgga      300

ggggggacca agctggaaat aaaac                                            325


<210>  17
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-TSPAN3 M1 clone light chain variable region amino
       acid sequence

<400>  17

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile His Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Ser Thr Pro Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  18
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-TSPAN3 M1 clone light chain CDR1 amino acid 
       sequence

<400>  18

Gly Asn Ile His Asn Tyr 
1               5       


<210>  19
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-TSPAN3 M1 clone light chain CDR2 amino acid 
       sequence

<400>  19

Asn Ala Lys 
1           


<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-TSPAN3 M1 clone light chain CDR3 amino acid 
       sequence

<400>  20

Gln His Phe Trp Ser Thr Pro Pro Tyr Thr 
1               5                   10  


<210>  21
<211>  319
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-TSPAN3 M2 clone light chain variable region DNA 
       sequence

<400>  21
gaaattgtgc tcactcagtc tccagccatc acagctgcat ctctggggca aaaggtcacc       60

atcacctgca gtgccagctc aagtgtaagt tacatgaact ggtaccagca gaagtcaggc      120

acctccccca aaccatggat ttatgaaata tccaaactgg cttctggagt cccagttcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagcat ggaggctgaa      240

gatgctgcca tttattactg ccagcagtgg aattatcctc ttatcacgtt cggagggggg      300

accaagctgg aaataaaac                                                   319


<210>  22
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-TSPAN3 M2 clone light chain variable region amino
       acid sequence

<400>  22

Glu Ile Val Leu Thr Gln Ser Pro Ala Ile Thr Ala Ala Ser Leu Gly 
1               5                   10                  15      


Gln Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Glu Ile Ser Lys Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Ile Tyr Tyr Cys Gln Gln Trp Asn Tyr Pro Leu Ile Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  23
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-TSPAN3 M2 clone light chain CDR1 amino acid 
       sequence

<400>  23

Ser Ser Val Ser Tyr 
1               5   


<210>  24
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-TSPAN3 M2 clone light chain CDR2 amino acid 
       sequence

<400>  24

Glu Ile Ser 
1           


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-TSPAN3 M2 clone light chain CDR3 amino acid 
       sequence

<400>  25

Gln Gln Trp Asn Tyr Pro Leu Ile Thr 
1               5                   


<210>  26
<211>  322
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-TSPAN3 M3 clone light chain variable region DNA 
       sequence

<400>  26
gacattgtga tgacccagtc tcacaaattc atgtccacat cagtaggaga cagggtcagc       60

atcacctgca aggccagtca ggatgtgggt actgctgtag cctggtatca acagaaacca      120

gggcaatctc ctaaactact gatttactgg gcatccaccc ggcacactgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccattagcaa tgtgcagtct      240

gaagacttgg cagattattt ctgtcagcaa tatagcagct atccgctcac gttcggtgct      300

gggaccaagc tggagctgaa ac                                               322


<210>  27
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-TSPAN3 M3 clone light chain variable region amino
       acid sequence

<400>  27

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  28
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-TSPAN3 M3 clone light chain CDR1 amino acid 
       sequence

<400>  28

Gln Asp Val Gly Thr Ala 
1               5       


<210>  29
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-TSPAN3 M3 clone light chain CDR2 amino acid 
       sequence

<400>  29

Trp Ala Ser 
1           


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-TSPAN3 M3 clone light chain CDR3 amino acid 
       sequence

<400>  30

Gln Gln Tyr Ser Ser Tyr Pro Leu Thr 
1               5                   


<210>  31
<211>  334
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-TSPAN3 M5/M6 clone light chain variable region 
       DNA sequence

<400>  31
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctggggca gagggccacc       60

atctcctgca gagccagcga aagtcttggt aattatggca ttagctatat gaactggttc      120

caacagaaac caggacagcc acccaaactc ctcatctatg ctgcatccaa ccaaggatcc      180

ggggtccctg tcaggtttag tggcagtggg tccgggacag acttcagcct caacatccat      240

cctatggagg aggatgatac tgcaatgtat ttctgtcagc aaagtaagga agttccgtgg      300

acgttcggtg gaggcaccaa gctggaaatc aaac                                  334


<210>  32
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-TSPAN3 M5/M6 clone light chain variable region 
       amino acid sequence

<400>  32

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Leu Gly Asn Tyr 
            20                  25                  30          


Gly Ile Ser Tyr Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Val 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  33
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-TSPAN3 M5/M6 clone light chain CDR1 amino acid 
       sequence

<400>  33

Glu Ser Leu Gly Asn Tyr Gly Ile Ser Tyr 
1               5                   10  


<210>  34
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-TSPAN3 M5/M6 clone light chain CDR2 amino acid 
       sequence

<400>  34

Ala Ala Ser 
1           


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-TSPAN3 M5/M6 clone light chain CDR3 amino acid 
       sequence

<400>  35

Gln Gln Ser Lys Glu Val Pro Trp Thr 
1               5                   


