                         SEQUENCE LISTING

<110>  GEORGIA TECH RESEARCH CORPORATION
 
<120>  SYNTHETIC ANTIGENS AS CHIMERIC ANTIGEN RECEPTOR (CAR) LIGANDS AND
        USES THEREOF

<130>  10034-069WO1

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  1

Met Ala Ser Pro Leu Thr Arg Phe Leu Ser Leu Asn Leu Leu Leu Leu 
1               5                   10                  15      


Gly Glu Ser Ile Ile Leu Gly Ser Gly Glu Ala Gly Pro Asp Ile Val 
            20                  25                  30          


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
        35                  40                  45              


Thr Ile Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr 
    50                  55                  60                  


Ala Ser Trp Val Gln Glu Lys Pro Gly Lys Leu Phe Lys Gly Leu Ile 
65                  70                  75                  80  


Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ser Arg Phe Ser Gly 
                85                  90                  95      


Ser Leu Ile Gly Asp Lys Ala Thr Leu Thr Ile Ser Ser Leu Gln Pro 
            100                 105                 110         


Glu Asp Phe Ala Thr Tyr Phe Cys Ala Leu Trp Tyr Ser Asn His Trp 
        115                 120                 125             


Val Phe Gly Gln Gly Thr Lys Val Glu Leu Lys Arg Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                165                 170                 175     


Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Thr Asp Tyr 
            180                 185                 190         


Gly Val Asn Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Ile 
        195                 200                 205             


Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala Leu Lys 
    210                 215                 220                 


Asp Arg Phe Ile Ile Ser Lys Asp Asn Gly Lys Asn Thr Val Tyr Leu 
225                 230                 235                 240 


Gln Met Ser Lys Val Arg Ser Asp Asp Thr Ala Leu Tyr Tyr Cys Val 
                245                 250                 255     


Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Thr Thr Thr Lys Pro Val Leu Arg Thr Pro Ser Pro Val His Pro 
        275                 280                 285             


Thr Gly Thr Ser Gln Pro Gln Arg Pro Glu Asp Cys Arg Pro Arg Gly 
    290                 295                 300                 


Ser Val Lys Gly Thr Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
305                 310                 315                 320 


Ala Pro Leu Ala Gly Ile Cys Val Ala Leu Leu Leu Ser Leu Ile Ile 
                325                 330                 335     


Thr Leu Ile Cys Tyr His Arg Ser Arg Asn Ser Arg Arg Asn Arg Leu 
            340                 345                 350         


Leu Gln Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Leu Thr 
        355                 360                 365             


Arg Lys Pro Tyr Gln Pro Tyr Ala Pro Ala Arg Asp Phe Ala Ala Tyr 
    370                 375                 380                 


Arg Pro Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp Pro Asn 
385                 390                 395                 400 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
                405                 410                 415     


Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu Met Gly Gly Lys Gln Gln 
            420                 425                 430         


Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Thr Leu Ala 
                485                 490             


<210>  2
<211>  496
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  2

Met Ala Ser Pro Leu Thr Arg Phe Leu Ser Leu Asn Leu Leu Leu Leu 
1               5                   10                  15      


Gly Glu Ser Ile Ile Leu Gly Ser Gly Glu Ala Gly Val Lys Leu Asp 
            20                  25                  30          


Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly Ala Met Lys Leu Ser 
        35                  40                  45              


Cys Val Thr Ser Gly Phe Thr Phe Gly His Tyr Trp Met Asn Trp Val 
    50                  55                  60                  


Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val Ala Gln Phe Arg Asn 
65                  70                  75                  80  


Lys Pro Tyr Asn Tyr Glu Thr Tyr Tyr Ser Asp Ser Val Lys Gly Arg 
                85                  90                  95      


Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser Val Tyr Leu Gln Met 
            100                 105                 110         


Asn Asn Leu Arg Val Glu Asp Thr Gly Ile Tyr Tyr Cys Thr Gly Ala 
        115                 120                 125             


Ser Tyr Gly Met Glu Tyr Leu Gly Gln Gly Thr Ser Val Thr Val Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro 
                165                 170                 175     


Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
            180                 185                 190         


Leu Val His Ser Asn Gly Asn Thr Tyr Leu Arg Trp Tyr Leu Gln Lys 
        195                 200                 205             


Pro Gly Gln Ser Pro Lys Val Leu Ile Tyr Lys Val Ser Asn Arg Val 
    210                 215                 220                 


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
225                 230                 235                 240 


Thr Leu Lys Ile Asn Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe 
                245                 250                 255     


Cys Ser Gln Ser Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys 
            260                 265                 270         


Leu Glu Ile Lys Thr Thr Thr Lys Pro Val Leu Arg Thr Pro Ser Pro 
        275                 280                 285             


Val His Pro Thr Gly Thr Ser Gln Pro Gln Arg Pro Glu Asp Cys Arg 
    290                 295                 300                 


Pro Arg Gly Ser Val Lys Gly Thr Gly Leu Asp Phe Ala Cys Asp Ile 
305                 310                 315                 320 


Tyr Ile Trp Ala Pro Leu Ala Gly Ile Cys Val Ala Leu Leu Leu Ser 
                325                 330                 335     


Leu Ile Ile Thr Leu Ile Cys Tyr His Arg Ser Arg Asn Ser Arg Arg 
            340                 345                 350         


Asn Arg Leu Leu Gln Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
        355                 360                 365             


Gly Leu Thr Arg Lys Pro Tyr Gln Pro Tyr Ala Pro Ala Arg Asp Phe 
    370                 375                 380                 


Ala Ala Tyr Arg Pro Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln 
385                 390                 395                 400 


Asp Pro Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
                405                 410                 415     


Tyr Asp Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu Met Gly Gly 
            420                 425                 430         


Lys Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu 
        435                 440                 445             


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly 
    450                 455                 460                 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
465                 470                 475                 480 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Thr Leu Ala 
                485                 490                 495     


<210>  3
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  3

Ala Asn Ile Val Met Thr Gln Thr Pro Ala Ser Val Ser Gly Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Thr 
            20                  25                  30          


Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gln Ala Ser Glu Leu Ala Tyr Gly Val Ser Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Val Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Asp Ile 
                85                  90                  95      


Asn Val Asp Asn Phe Phe Gly Gly Gly Thr Glu Val Val Val Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser 
        115                 120                 125             


Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro Leu Thr 
    130                 135                 140                 


Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Asn Tyr Thr Val Ile 
145                 150                 155                 160 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Ile Ile 
                165                 170                 175     


Phe Gly Ser Gly Gly Thr Tyr Tyr Ala Thr Trp Ala Glu Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Met Thr Ser Pro 
        195                 200                 205             


Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Tyr Phe Gly 
    210                 215                 220                 


Asn Thr Phe Trp Ala Met Asp Pro Trp Gly Pro Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  4
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  4

Met Ala Ser Pro Leu Thr Arg Phe Leu Ser Leu Asn Leu Leu Leu Leu 
1               5                   10                  15      


Gly Glu Ser Ile Ile Leu Gly Ser Gly Glu Ala Ala Asn Ile Val Met 
            20                  25                  30          


Thr Gln Thr Pro Ala Ser Val Ser Gly Ala Val Gly Gly Thr Val Thr 
        35                  40                  45              


Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Thr Tyr Leu Ser Trp Tyr 
    50                  55                  60                  


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Gln Ala Ser 
65                  70                  75                  80  


Glu Leu Ala Tyr Gly Val Ser Ser Arg Phe Lys Gly Ser Gly Ser Gly 
                85                  90                  95      


Thr Glu Phe Thr Leu Thr Ile Ser Gly Val Glu Cys Ala Asp Ala Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Asp Ile Asn Val Asp Asn Phe 
        115                 120                 125             


Phe Gly Gly Gly Thr Glu Val Val Val Lys Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Glu Glu Ser Gly 
145                 150                 155                 160 


Gly Arg Leu Val Thr Pro Gly Thr Pro Leu Thr Leu Thr Cys Thr Val 
                165                 170                 175     


Ser Gly Phe Ser Leu Asn Asn Tyr Thr Val Ile Trp Val Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Gly Leu Glu Trp Ile Gly Ile Ile Phe Gly Ser Gly Gly 
        195                 200                 205             


Thr Tyr Tyr Ala Thr Trp Ala Glu Gly Arg Phe Thr Ile Ser Arg Thr 
    210                 215                 220                 


Ser Thr Thr Val Asp Leu Lys Met Thr Ser Pro Thr Thr Glu Asp Thr 
225                 230                 235                 240 


Ala Thr Tyr Phe Cys Ala Arg Gly Tyr Phe Gly Asn Thr Phe Trp Ala 
                245                 250                 255     


Met Asp Pro Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Thr Thr 
            260                 265                 270         


Thr Lys Pro Val Leu Arg Thr Pro Ser Pro Val His Pro Thr Gly Thr 
        275                 280                 285             


Ser Gln Pro Gln Arg Pro Glu Asp Cys Arg Pro Arg Gly Ser Val Lys 
    290                 295                 300                 


Gly Thr Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
305                 310                 315                 320 


Ala Gly Ile Cys Val Ala Leu Leu Leu Ser Leu Ile Ile Thr Leu Ile 
                325                 330                 335     


Cys Tyr His Arg Ser Arg Asn Ser Arg Arg Asn Arg Leu Leu Gln Ser 
            340                 345                 350         


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Leu Thr Arg Lys Pro 
        355                 360                 365             


Tyr Gln Pro Tyr Ala Pro Ala Arg Asp Phe Ala Ala Tyr Arg Pro Ser 
    370                 375                 380                 


Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp Pro Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Glu Lys 
                405                 410                 415     


Lys Arg Ala Arg Asp Pro Glu Met Gly Gly Lys Gln Gln Arg Arg Arg 
            420                 425                 430         


Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Thr Leu Ala 
                485                 490 


<210>  5
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  5

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Pro Asp Ile Val Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ser 
        35                  40                  45              


Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Ser Trp Val Gln Glu 
    50                  55                  60                  


Lys Pro Gly Lys Leu Phe Lys Gly Leu Ile Gly Gly Thr Asn Asn Arg 
65                  70                  75                  80  


Ala Pro Gly Val Pro Ser Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys 
                85                  90                  95      


Ala Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
            100                 105                 110         


Phe Cys Ala Leu Trp Tyr Ser Asn His Trp Val Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Val Glu Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Glu Val Lys Leu Leu Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys 
                165                 170                 175     


Ala Val Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val Asn Trp Val Arg 
            180                 185                 190         


Gln Ala Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Ile Trp Gly Asp 
        195                 200                 205             


Gly Ile Thr Asp Tyr Asn Ser Ala Leu Lys Asp Arg Phe Ile Ile Ser 
    210                 215                 220                 


Lys Asp Asn Gly Lys Asn Thr Val Tyr Leu Gln Met Ser Lys Val Arg 
225                 230                 235                 240 


Ser Asp Asp Thr Ala Leu Tyr Tyr Cys Val Thr Gly Leu Phe Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490 


<210>  6
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  6

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Val Lys Leu Asp Glu Thr Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ala Met Lys Leu Ser Cys Val Thr Ser Gly Phe 
        35                  40                  45              


Thr Phe Gly His Tyr Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Gln Phe Arg Asn Lys Pro Tyr Asn Tyr Glu 
65                  70                  75                  80  


Thr Tyr Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                85                  90                  95      


Asp Ser Lys Ser Ser Val Tyr Leu Gln Met Asn Asn Leu Arg Val Glu 
            100                 105                 110         


Asp Thr Gly Ile Tyr Tyr Cys Thr Gly Ala Ser Tyr Gly Met Glu Tyr 
        115                 120                 125             


Leu Gly Gln Gly Thr Ser Val Thr Val Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val 
145                 150                 155                 160 


Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln 
                165                 170                 175     


Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly 
            180                 185                 190         


Asn Thr Tyr Leu Arg Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys 
        195                 200                 205             


Val Leu Ile Tyr Lys Val Ser Asn Arg Val Ser Gly Val Pro Asp Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Asn Arg 
225                 230                 235                 240 


Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser Thr His 
                245                 250                 255     


Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  7
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  7

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ala Asn Ile Val Met Thr Gln Thr Pro Ala Ser 
            20                  25                  30          


Val Ser Gly Ala Val Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser 
        35                  40                  45              


Gln Ser Ile Ser Thr Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Pro Pro Lys Leu Leu Ile Tyr Gln Ala Ser Glu Leu Ala Tyr Gly Val 
65                  70                  75                  80  


Ser Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Gly Val Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Gly Tyr Ser Asp Ile Asn Val Asp Asn Phe Phe Gly Gly Gly Thr Glu 
        115                 120                 125             


Val Val Val Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro 
145                 150                 155                 160 


Gly Thr Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn 
                165                 170                 175     


Asn Tyr Thr Val Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
            180                 185                 190         


Trp Ile Gly Ile Ile Phe Gly Ser Gly Gly Thr Tyr Tyr Ala Thr Trp 
        195                 200                 205             


Ala Glu Gly Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu 
    210                 215                 220                 


Lys Met Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
225                 230                 235                 240 


Arg Gly Tyr Phe Gly Asn Thr Phe Trp Ala Met Asp Pro Trp Gly Pro 
                245                 250                 255     


Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  8
<211>  539
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  8
gaaataagag agaaaagaag agtaagaaga aatataagag ccaccatgaa atgggtcaca       60

tttatatctc tgctcttcct tttctcttca gcctacagcg aggaactgct gagcaagaac      120

taccacctgg aaaacgaggt ggcccggctg aaaaaaggct ctggctctgg cgaagaactg      180

ctgtctaaga attatcacct cgagaatgag gtcgcccgcc tcaagaaagg atctggaagt      240

ggcgaggaac tcctctccaa aaactaccat ctcgagaacg aagtcgctag gcttaagaaa      300

ggaggcgggg gcagccacga gaccaccccc aacaagggga gcgggaccac gtccggcaca      360

actagactgc tttccggcca tacatgcttt acacttactg ggctgctggg gactcttgta      420

actatggggc tcctcacatg ataggctgcc ttctgcgggg cttgccttct ggccatgccc      480

ttcttctctc ccttgcacct gtacctcttg gtctttgaat aaagcctgag taggaaggc       539


<210>  9
<211>  569
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  9
gaaataagag agaaaagaag agtaagaaga aatataagag ccaccatgaa atgggtcaca       60

tttatatctc tgctcttcct tttctcttca gcctacagcg aggaactgct gagcaagaac      120

taccacctgg aaaacgaggt ggcccggctg aaaaaaggct ctggctctgg cgaagaactg      180

ctgtctaaga attatcacct cgagaatgag gtcgcccgcc tcaagaaagg atctggaagt      240

ggcgaggaac tcctctccaa aaactaccat ctcgagaacg aagtcgctag gcttaagaaa      300

ggaggcgggg gcagcggagg cgggggcagc ggaggcgggg gcagccacga gaccaccccc      360

aacaagggga gcgggaccac gtccggcaca actagactgc tttccggcca tacatgcttt      420

acacttactg ggctgctggg gactcttgta actatggggc tcctcacatg ataggctgcc      480

ttctgcgggg cttgccttct ggccatgccc ttcttctctc ccttgcacct gtacctcttg      540

gtctttgaat aaagcctgag taggaaggc                                        569


<210>  10
<211>  929
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  10
gaaataagag agaaaagaag agtaagaaga aatataagag ccaccatgaa atgggtcaca       60

tttatatctc tgctcttcct tttctcttca gcctacagcg aggaactgct gagcaagaac      120

taccacctgg aaaacgaggt ggcccggctg aaaaaaggct ctggctctgg cgaagaactg      180

ctgtctaaga attatcacct cgagaatgag gtcgcccgcc tcaagaaagg atctggaagt      240

ggcgaggaac tcctctccaa aaactaccat ctcgagaacg aagtcgctag gcttaagaaa      300

ggaggcgggg gcagccaggt acagttgcag gagtccggag gtggtctggt acaaccaggt      360

ggatccctca gattgtcttg tgcagctagt ggctttacgc tcgactacta ttatatcggg      420

tggtttcggc aagcaccggg taaagagagg gaggctgtta gctgtatcag cggctcttca      480

gggtccacgt attaccctga cagtgttaaa gggagattta ccatatcccg cgataacgca      540

aagaacactg tgtacttgca gatgaatagc ctgaagcccg aggacacagc cgtttactac      600

tgtgccacga ttcgctcctc ttcatgggga ggatgcgttc attacgggat ggattactgg      660

ggcaaaggca ctcaggtgac ggttagctct ggaggcgggg gcagccacga gaccaccccc      720

aacaagggga gcgggaccac gtccggcaca actagactgc tttccggcca tacatgcttt      780

acacttactg ggctgctggg gactcttgta actatggggc tcctcacatg ataggctgcc      840

ttctgcgggg cttgccttct ggccatgccc ttcttctctc ccttgcacct gtacctcttg      900

gtctttgaat aaagcctgag taggaaggc                                        929


<210>  11
<211>  713
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  11
gaaataagag agaaaagaag agtaagaaga aatataagag ccaccatgaa atgggtcaca       60

tttatatctc tgctcttcct tttctcttca gcctacagcc aggtacagtt gcaggagtcc      120

ggaggtggtc tggtacaacc aggtggatcc ctcagattgt cttgtgcagc tagtggcttt      180

acgctcgact actattatat cgggtggttt cggcaagcac cgggtaaaga gagggaggct      240

gttagctgta tcagcggctc ttcagggtcc acgtattacc ctgacagtgt taaagggaga      300

tttaccatat cccgcgataa cgcaaagaac actgtgtact tgcagatgaa tagcctgaag      360

cccgaggaca cagccgttta ctactgtgcc acgattcgct cctcttcatg gggaggatgc      420

gttcattacg ggatggatta ctggggcaaa ggcactcagg tgacggttag ctctggaggc      480

gggggcagcc acgagaccac ccccaacaag gggagcggga ccacgtccgg cacaactaga      540

ctgctttccg gccatacatg ctttacactt actgggctgc tggggactct tgtaactatg      600

gggctcctca catgataggc tgccttctgc ggggcttgcc ttctggccat gcccttcttc      660

tctcccttgc acctgtacct cttggtcttt gaataaagcc tgagtaggaa ggc             713


<210>  12
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  12

Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg 
1               5                   10                  15      


Leu Lys Lys 
            


<210>  13
<211>  8
<212>  PRT
<213>  Gallus gallus

<400>  13

Ser Ile Ile Asn Phe Glu Lys Leu 
1               5               


<210>  14
<211>  9
<212>  PRT
<213>  Influenza A virus

<400>  14

Gly Ile Leu Gly Phe Val Phe Thr Leu 
1               5                   


<210>  15
<211>  9
<212>  PRT
<213>  Influenza A virus

<400>  15

Gly Pro Pro Gln Trp Asn Asn Pro Pro 
1               5                   


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synethtic construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is leucine (Leu) or Isoleucine (Ile)

<400>  16

Asp Tyr Xaa Asp Asp Asp Asp Lys 
1               5               


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  17

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


