                               SEQUENCE LISTING

<110> DANA-FARBER CANCER INSTITUTE, INC.
 
<120> CHIMERIC CONJUGATES FOR DEGRADATION OF VIRAL AND HOST PROTEINS 
      AND METHODS OF USE

<130> 00530-0409WO1

<140>
<141>

<150> 63/091,769
<151> 2020-10-14

<160> 55    

<170> PatentIn version 3.5

<210> 1
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> (R)-2-(7'-octenyl)alanine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> (S)-2-(4'-pentenyl)alanine

<400> 1
Leu Thr Phe Xaa Glu Tyr Trp Ala Gln Leu Xaa Ser Ala Ala 
1               5                   10                  


<210> 2
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 2
Ala Thr Val Asn Val Leu Ala Trp Leu Tyr Ala Ala Val Ile Asn Gly 
1               5                   10                  15      


Asp 
    


<210> 3
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (11)..(11)
<223> (S)-2-(4'-pentenyl)alanine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> (S)-2-(4'-pentenyl)alanine

<400> 3
Ala Thr Val Asn Val Leu Ala Trp Leu Tyr Xaa Ala Val Ile Xaa Gly 
1               5                   10                  15      


Asp 
    


<210> 4
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Norleucine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> (S)-2-(4'-pentenyl)alanine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> (S)-2-(4'-pentenyl)alanine

<400> 4
Ala Asn Leu Asn Ala Gly Xaa Xaa Leu Gly Ser Xaa Ala Ala Thr Val 
1               5                   10                  15      


Glu Leu Gln 
            


<210> 5
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Norleucine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> (S)-2-(4'-pentenyl)alanine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> (S)-2-(4'-pentenyl)alanine

<400> 5
Ala Asn Leu Asn Arg Gly Xaa Xaa Leu Gly Ser Xaa Ala Ala Thr Val 
1               5                   10                  15      


Arg Leu Gln 
            


<210> 6
<211> 7
<212> PRT
<213> Homo sapiens

<400> 6
Asp Gln Ile Val Pro Glu Tyr 
1               5           


<210> 7
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> (R)-2-(7'-octenyl)alanine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Cyclobutylalanine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> (S)-2-(4'-pentenyl)alanine

<400> 7
Leu Thr Phe Xaa Glu Tyr Trp Ala Gln Xaa Xaa Ser Ala Ala 
1               5                   10                  


<210> 8
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (2)..(4)
<223> Any amino acid

<220>
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 8
Gly Xaa Xaa Xaa Gly 
1               5   


<210> 9
<211> 16
<212> PRT
<213> Severe acute respiratory syndrome coronavirus 2

<400> 9
Thr Val Asn Val Leu Ala Trp Leu Tyr Ala Ala Val Ile Asn Gly Asp 
1               5                   10                  15      


<210> 10
<211> 18
<212> PRT
<213> Severe acute respiratory syndrome coronavirus 2

<400> 10
Asn Leu Asn Arg Gly Met Val Leu Gly Ser Leu Ala Ala Thr Val Arg 
1               5                   10                  15      


Leu Gln 
        


<210> 11
<211> 16
<212> PRT
<213> Homo sapiens

<400> 11
Leu Ser Gln Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn 
1               5                   10                  15      


<210> 12
<211> 14
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown:
      E3 ligase peptide"

<400> 12
Leu Ala Pro Ala Ala Gly Asp Thr Ile Ile Ser Leu Asp Phe 
1               5                   10                  


<210> 13
<211> 13
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown:
      E3 ligase peptide"

<400> 13
Leu Ala Pro Tyr Ile Pro Met Asp Asp Asp Phe Gln Leu 
1               5                   10              


<210> 14
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Any amino acid except Pro

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid except Pro

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid except Pro

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Any amino acid except Pro

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Any amino acid except Pro

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Any amino acid except Pro

<220>
<221> SITE
<222> (6)..(8)
<223> /note="This region may encompass 2-3 residues"

<220>
<221> VARIANT
<222> (9)..(9)
<223> /replace="Ile" or "Leu"

<220>
<221> SITE
<222> (1)..(9)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<400> 14
Phe Xaa Xaa Xaa Trp Xaa Xaa Xaa Val 
1               5                   


<210> 15
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (1)..(1)
<223> /replace="Leu"

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Any amino acid

<220>
<221> SITE
<222> (4)..(11)
<223> /note="This region may encompass 6-8 residues"

<220>
<221> VARIANT
<222> (12)..(12)
<223> /replace="Leu" or "Ile" or "Val" or "Met"

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Any amino acid

<220>
<221> VARIANT
<222> (14)..(14)
<223> /replace="Leu" or "Ile" or "Val" or "Met"

<220>
<221> SITE
<222> (1)..(14)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<400> 15
Ile Ala Pro Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe Xaa Phe 
1               5                   10                  


<210> 16
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 16
Gly Gly Gly Ser 
1               


<210> 17
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 17
Ser Gly Gly Gly 
1               


<210> 18
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 18
Gly Gly Gly Gly Ser 
1               5   


<210> 19
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 19
Ser Gly Gly Gly Gly 
1               5   


<210> 20
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 20
Gly Gly Gly Gly Gly Ser 
1               5       


<210> 21
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 21
Ser Gly Gly Gly Gly Gly 
1               5       


<210> 22
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 22
Gly Gly Gly Gly Gly Gly Ser 
1               5           


<210> 23
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 23
Ser Gly Gly Gly Gly Gly Gly 
1               5           


<210> 24
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 24
Gly Gly Gly Gly Ser 
1               5   


<210> 25
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 25
Ser Gly Gly Gly Gly 
1               5   


<210> 26
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 26
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 27
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 27
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210> 28
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(5)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (14)..(15)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (19)..(20)
<223> Any amino acid

<220>
<221> SITE
<222> (1)..(20)
<223> /note="This region may encompass 0-4 'Gly Gly Gly Xaa Xaa'
      repeating units"

<220>
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 28
Gly Gly Gly Xaa Xaa Gly Gly Gly Xaa Xaa Gly Gly Gly Xaa Xaa Gly 
1               5                   10                  15      


Gly Gly Xaa Xaa Gly Gly Gly Gly Ser 
            20                  25  


<210> 29
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Any amino acid

<220>
<221> SITE
<222> (6)..(25)
<223> /note="This region may encompass 0-4 'Xaa Gly Gly Gly Ser'
      repeating units"

<220>
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 29
Gly Gly Gly Gly Ser Xaa Gly Gly Gly Ser Xaa Gly Gly Gly Ser Xaa 
1               5                   10                  15      


Gly Gly Gly Ser Xaa Gly Gly Gly Ser 
            20                  25  


<210> 30
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> SITE
<222> (1)..(20)
<223> /note="This region may encompass 0-4 'Gly Gly Gly Pro Ser'
      repeating units"

<400> 30
Gly Gly Gly Pro Ser Gly Gly Gly Pro Ser Gly Gly Gly Pro Ser Gly 
1               5                   10                  15      


Gly Gly Pro Ser Gly Gly Gly Gly Ser 
            20                  25  


<210> 31
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> SITE
<222> (1)..(20)
<223> /note="This region may encompass 0-4 'Gly Gly Gly Gly Gln'
      repeating units"

<400> 31
Gly Gly Gly Gly Gln Gly Gly Gly Gly Gln Gly Gly Gly Gly Gln Gly 
1               5                   10                  15      


Gly Gly Gly Gln Gly Gly Gly Gly Ser 
            20                  25  


<210> 32
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> SITE
<222> (1)..(20)
<223> /note="This region may encompass 0-4 'Gly Gly Gly Gly Ala'
      repeating units"

<400> 32
Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly 
1               5                   10                  15      


Gly Gly Gly Ala Gly Gly Gly Gly Ser 
            20                  25  


<210> 33
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> SITE
<222> (6)..(25)
<223> /note="This region may encompass 0-4 'Pro Gly Gly Gly Ser'
      repeating units"

<400> 33
Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Pro Gly Gly Gly Ser Pro 
1               5                   10                  15      


Gly Gly Gly Ser Pro Gly Gly Gly Ser 
            20                  25  


<210> 34
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 34
Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 35
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 35
Gly Gly Gly Gly Gln Gly Gly Gly Gly Gln Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 36
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 36
Gly Gly Gly Pro Ser Gly Gly Gly Pro Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 37
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 37
Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Pro Gly Gly Gly Ser 
1               5                   10                  15  


<210> 38
<211> 8
<212> PRT
<213> Homo sapiens

<400> 38
Phe Ser Asp Leu Trp Lys Leu Leu 
1               5               


<210> 39
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 39
Thr Ser Phe Ala Glu Tyr Trp Asn Leu Leu Ser Pro 
1               5                   10          


<210> 40
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (9)..(9)
<223> (R)-2-(7'-octenyl)alanine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> (S)-2-(4'-pentenyl)alanine

<400> 40
Leu Ser Gln Glu Thr Phe Ser Asp Xaa Trp Lys Leu Leu Pro Glu Xaa 
1               5                   10                  15      


<210> 41
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (5)..(5)
<223> (R)-2-(7'-octenyl)alanine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> (S)-2-(4'-pentenyl)alanine

<400> 41
Leu Ser Gln Glu Xaa Phe Ser Asp Leu Trp Lys Xaa Leu Pro Glu Asn 
1               5                   10                  15      


<210> 42
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> (R)-2-(7'-octenyl)alanine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> (S)-2-(4'-pentenyl)alanine

<400> 42
Leu Ser Gln Xaa Thr Phe Ser Asp Leu Trp Xaa Leu Leu Pro Glu Asn 
1               5                   10                  15      


<210> 43
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> (R)-2-(7'-octenyl)alanine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> (S)-2-(4'-pentenyl)alanine

<400> 43
Leu Ser Gln Glu Thr Phe Xaa Asp Leu Trp Lys Leu Leu Xaa Glu Asn 
1               5                   10                  15      


<210> 44
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> (R)-2-(7'-octenyl)alanine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> (S)-2-(4'-pentenyl)alanine

<400> 44
Leu Ser Gln Glu Thr Phe Xaa Asn Leu Trp Lys Leu Leu Xaa Gln Asn 
1               5                   10                  15      


<210> 45
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> (R)-2-(7'-octenyl)alanine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> (S)-2-(4'-pentenyl)alanine

<400> 45
Leu Ser Gln Gln Thr Phe Xaa Asn Leu Trp Arg Leu Leu Xaa Gln Asn 
1               5                   10                  15      


<210> 46
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> (R)-2-(7'-octenyl)alanine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> (S)-2-(4'-pentenyl)alanine

<400> 46
Gln Ser Gln Gln Thr Phe Xaa Asn Leu Trp Lys Leu Leu Xaa Gln Asn 
1               5                   10                  15      


<210> 47
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> (R)-2-(7'-octenyl)alanine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> (S)-2-(4'-pentenyl)alanine

<400> 47
Gln Ser Gln Gln Thr Phe Xaa Asn Leu Trp Arg Leu Leu Xaa Gln Asn 
1               5                   10                  15      


<210> 48
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> (R)-2-(7'-octenyl)alanine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Any amino acid

<220>
<221> VARIANT
<222> (7)..(7)
<223> /replace="F" or "3-(2-naphthyl)-L-alanine"

<220>
<221> VARIANT
<222> (10)..(10)
<223> /replace="Cyclobutylalanine"

<220>
<221> MOD_RES
<222> (11)..(11)
<223> (S)-2-(4'-pentenyl)alanine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Any amino acid

<220>
<221> SITE
<222> (1)..(14)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 48
Xaa Thr Phe Xaa Xaa Tyr Trp Ala Gln Leu Xaa Xaa Ala Ala 
1               5                   10                  


<210> 49
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> (R)-2-(4'-pentenyl)alanine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> (S)-2-(7'-octenyl)alanine

<400> 49
Leu Thr Phe Xaa Glu Tyr Trp Ala Gln Leu Xaa Ser Ala Ala 
1               5                   10                  


<210> 50
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> (R)-2-(4'-pentenyl)alanine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Cyclobutylalanine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> (S)-2-(7'-octenyl)alanine

<400> 50
Leu Thr Phe Xaa Glu Tyr Trp Ala Gln Xaa Xaa Ser Ala Ala 
1               5                   10                  


<210> 51
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (3)..(3)
<223> (S)-2-(4'-pentenyl)alanine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> (S)-2-(4'-pentenyl)alanine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> (S)-2-(4'-pentenyl)alanine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> (S)-2-(4'-pentenyl)alanine

<220>
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 51
Ala Thr Xaa Asn Val Leu Xaa Trp Leu Tyr Xaa Ala Val Ile Xaa Gly 
1               5                   10                  15      


Asp 
    


<210> 52
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Norleucine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> (S)-2-(4'-pentenyl)alanine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> (S)-2-(4'-pentenyl)alanine

<220>
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 52
Ala Asn Leu Asn Ala Gly Xaa Xaa Leu Gly Ser Xaa Ala Ala Thr Val 
1               5                   10                  15      


Glu Leu Gln 
            


<210> 53
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      6xHis tag"

<400> 53
His His His His His His 
1               5       


<210> 54
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Norleucine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> (S)-2-(4'-pentenyl)alanine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> (S)-2-(4'-pentenyl)alanine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Beta-alanine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> (R)-2-(7'-octenyl)alanine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> (S)-2-(4'-pentenyl)alanine

<400> 54
Ala Asn Leu Asn Ala Gly Xaa Xaa Leu Gly Ser Xaa Ala Ala Thr Val 
1               5                   10                  15      


Glu Leu Gln Xaa Ala Leu Thr Phe Xaa Glu Tyr Trp Ala Gln Leu Xaa 
            20                  25                  30          


Ser Ala Ala 
        35  


<210> 55
<211> 34
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> (R)-2-(7'-octenyl)alanine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> (S)-2-(4'-pentenyl)alanine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Beta-alanine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Norleucine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> (S)-2-(4'-pentenyl)alanine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> (S)-2-(4'-pentenyl)alanine

<400> 55
Leu Thr Phe Xaa Glu Tyr Trp Ala Gln Leu Xaa Ser Ala Ala Xaa Ala 
1               5                   10                  15      


Asn Leu Asn Ala Gly Xaa Xaa Leu Gly Ser Xaa Ala Ala Thr Val Glu 
            20                  25                  30          


Leu Gln 
        


