                         SEQUENCE LISTING

<110>  KRIYA THERAPEUTICS, INC.
       FURMANSKI, BRIAN
       GUPTA, NACHI
       SCHNEPP, BRUCE
       STONE, MICHELE

 
<120>  VIRAL VECTOR CONSTRUCTS FOR DELIVERY OF NUCLEIC ACIDS ENCODING 
       CYTOKINES AND USES THEREOF FOR TREATING CANCER

<130>  4525.032PC04

<150>  US 63/182,632
<151>  2021-04-30

<150>  US 63/141,921
<151>  2021-01-26

<150>  US 63/108,838
<151>  2020-11-02

<150>  US 63/091,270
<151>  2020-10-13

<160>  92    

<170>  PatentIn version 3.5

<210>  1
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Proteolytic furin cleavage site


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Wherein Xaa is a naturally occuring amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Wherein Xaa can be either Lys or Arg

<400>  1

Arg Xaa Xaa Arg 
1               


<210>  2
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kozak consensus sequence

<400>  2
gccgccatg                                                                9


<210>  3
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kozak consensus sequence

<400>  3
gcggccgcca tg                                                           12


<210>  4
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Kozak consensus sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Wherein N can be either adenine or guanine

<400>  4
ccnccaugg                                                                9


<210>  5
<211>  660
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IL-12A (p35) ("wild-type" no CpG modification)

<400>  5
atgtgtccag cgcgcagcct cctccttgtg gctaccctgg tcctcctgga ccacctcagt       60

ttggccagaa acctccccgt ggccactcca gacccaggaa tgttcccatg ccttcaccac      120

tcccaaaacc tgctgagggc cgtcagcaac atgctccaga aggccagaca aactctagaa      180

ttttaccctt gcacttctga agagattgat catgaagata tcacaaaaga taaaaccagc      240

acagtggagg cctgtttacc attggaatta accaagaatg agagttgcct aaattccaga      300

gagacctctt tcataactaa tgggagttgc ctggcctcca gaaagacctc ttttatgatg      360

gccctgtgcc ttagtagtat ttatgaagac ttgaagatgt accaggtgga gttcaagacc      420

atgaatgcaa agcttctgat ggatcctaag aggcagatct ttctagatca aaacatgctg      480

gcagttattg atgagctgat gcaggccctg aatttcaaca gtgagactgt gccacaaaaa      540

tcctcccttg aagaaccgga tttttataaa actaaaatca agctctgcat acttcttcat      600

gctttccgga ttcgggcagt gactattgat agagtgatga gctatctgaa tgcttcctga      660


<210>  6
<211>  660
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IL-12A (p35) (with CpG modification)

<400>  6
atgtgtccag cgcgcagcct cctccttgtg gctaccctgg tcctcctgga ccacctcagt       60

ttggccagaa acctccctgt ggccactcca gacccaggaa tgttcccatg ccttcaccac      120

tcccaaaacc tgctgagggc tgtcagcaac atgctccaga aggccagaca aactctagaa      180

ttttaccctt gcacttctga agagattgat catgaagata tcacaaaaga taaaaccagc      240

acagtggagg cctgtttacc attggaatta accaagaatg agagttgcct aaattccaga      300

gagacctctt tcataactaa tgggagttgc ctggcctcca gaaagacctc ttttatgatg      360

gccctgtgcc ttagtagtat ttatgaagac ttgaagatgt accaggtgga gttcaagacc      420

atgaatgcaa agcttctgat ggatcctaag aggcagatct ttctagatca aaacatgctg      480

gcagttattg atgagctgat gcaggccctg aatttcaaca gtgagactgt gccacaaaaa      540

tcctcccttg aagaacctga tttttataaa actaaaatca agctctgcat acttcttcat      600

gctttccgga ttcgcgcagt gactattgat agagtgatga gctatctgaa tgcttcctga      660


<210>  7
<211>  660
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IL-12A (p35) (with CpG modification)

<400>  7
atgtgtccag ctaggagcct cctccttgtg gctaccctgg tcctcctgga ccacctcagt       60

ttggccagaa acctccctgt ggccactcca gacccaggaa tgttcccatg ccttcaccac      120

tcccaaaacc tgctgagggc agtcagcaac atgctccaga aggccagaca aactctagaa      180

ttttaccctt gcacttctga agagattgat catgaagata tcacaaaaga taaaaccagc      240

acagtggagg cctgtttacc attggaatta accaagaatg agagttgcct aaattccaga      300

gagacctctt tcataactaa tgggagttgc ctggcctcca gaaagacctc ttttatgatg      360

gccctgtgcc ttagtagtat ttatgaagac ttgaagatgt accaggtgga gttcaagacc      420

atgaatgcaa agcttctgat ggatcctaag aggcagatct ttctagatca aaacatgctg      480

gcagttattg atgagctgat gcaggccctg aatttcaaca gtgagactgt gccacaaaaa      540

tcctcccttg aagaacctga tttttataaa actaaaatca agctctgcat acttcttcat      600

gctttccgga ttagggcagt gactattgat agagtgatga gctatctgaa tgcttcctga      660


<210>  8
<211>  987
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IL-12B (p40) ("wild-type" no CpG modification and with stop
       codon)

<400>  8
atgtgtcacc agcagttggt catctcttgg ttttccctgg tttttctggc atctcccctc       60

gtggccatat gggaactgaa gaaagatgtt tatgtcgtag aattggattg gtatccggat      120

gcccctggag aaatggtggt cctcacctgt gacacccctg aagaagatgg tatcacctgg      180

accttggacc agagcagtga ggtcttaggc tctggcaaaa ccctgaccat ccaagtcaaa      240

gagtttggag atgctggcca gtacacctgt cacaaaggag gcgaggttct aagccattcg      300

ctcctgctgc ttcacaaaaa ggaagatgga atttggtcca ctgatatttt aaaggaccag      360

aaagaaccca aaaataagac ctttctaaga tgcgaggcca agaattattc tggacgtttc      420

acctgctggt ggctgacgac aatcagtact gatttgacat tcagtgtcaa aagcagcaga      480

ggctcttctg acccccaagg ggtgacgtgc ggagctgcta cactctctgc agagagagtc      540

agaggggaca acaaggagta tgagtactca gtggagtgcc aggaggacag tgcctgccca      600

gctgctgagg agagtctgcc cattgaggtg atggtggatg ccgttcacaa gctcaagtat      660

gaaaactaca ccagcagctt cttcatcagg gacatcatca aacctgaccc acccaagaac      720

ttgcagctga agccattaaa gaattctcgg caggtggagg tcagctggga gtaccctgac      780

acctggagta ctccacattc ctacttctcc ctgacattct gcgttcaagt ccagggcaag      840

agcaagagag aaaagaaaga tagagtcttc acggacaaga cctcagccac ggtcatctgc      900

cgcaaaaatg ccagcattag cgtgcgggcc caggaccgct actatagctc atcttggagc      960

gaatgggcat ctgtgccctg cagttga                                          987


<210>  9
<211>  986
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IL-12B (p40) (with CpG modification)

<400>  9
tgtgtcacca gcagttggtc atctcttggt tttccctggt ttttctggca tctccccttg       60

tggccatatg ggaactgaag aaagatgttt atgtggtaga attggattgg tatcctgatg      120

cccctggaga aatggtggtc ctcacctgtg acacccctga agaagatggt atcacctgga      180

ccttggacca gagcagtgag gtcttaggct ctggcaaaac cctgaccatc caagtcaaag      240

agtttggaga tgctggccag tacacctgtc acaaaggagg ggaggttcta agccattccc      300

tcctgctgct tcacaaaaag gaagatggaa tttggtccac tgatatttta aaggaccaga      360

aagaacccaa aaataagacc tttctaagat gtgaggccaa gaattattct ggaaggttca      420

cctgctggtg gctgactaca atcagtactg atttgacatt cagtgtcaaa agcagcagag      480

gctcttctga cccccaaggg gtgacatgcg gagctgctac actctctgca gagagagtca      540

gaggggacaa caaggagtat gagtactcag tggagtgcca ggaggacagt gcctgcccag      600

ctgctgagga gagtctgccc attgaggtga tggtggatgc ggttcacaag ctcaagtatg      660

aaaactacac cagcagcttc ttcatcaggg acatcatcaa acctgaccca cccaagaact      720

tgcagctgaa gccattaaag aattctaggc aggtggaggt cagctgggag taccctgaca      780

cctggagtac tccacattcc tacttctccc tgacattctg tgttcaagtc cagggcaaga      840

gcaagagaga aaagaaagat agagtcttca ctgacaagac ctcagccaca gtcatctgcc      900

gcaaaaatgc cagcatttca gtgcgggccc aggaccgcta ctatagctca tcttggtcag      960

aatgggcatc tgtgccctgc agttga                                           986


<210>  10
<211>  987
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IL-12B (p40) (with CpG modification)

<400>  10
atgtgtcacc agcagttggt catctcttgg ttttccctgg tttttctggc atctcccctt       60

gtggccatat gggaactgaa gaaagatgtt tatgtggtag aattggattg gtatcctgat      120

gcccctggag aaatggtggt cctcacctgt gacacccctg aagaagatgg tatcacctgg      180

accttggacc agagcagtga ggtcttaggc tctggcaaaa ccctgaccat ccaagtcaaa      240

gagtttggag atgctggcca gtacacctgt cacaaaggag gggaggttct aagccattcc      300

ctcctgctgc ttcacaaaaa ggaagatgga atttggtcca ctgatatttt aaaggaccag      360

aaagaaccca aaaataagac ctttctaaga tgtgaggcca agaattattc tggaaggttc      420

acctgctggt ggctgactac aatcagtact gatttgacat tcagtgtcaa aagcagcaga      480

ggctcttctg acccccaagg ggtgacatgt ggagctgcta cactctctgc agagagagtc      540

agaggggaca acaaggagta tgagtactca gtggagtgcc aggaggacag tgcctgccca      600

gctgctgagg agagtctgcc cattgaggtg atggtggatg cagttcacaa gctcaagtat      660

gaaaactaca ccagcagctt cttcatcagg gacatcatca aacctgaccc acccaagaac      720

ttgcagctga agccattaaa gaattctagg caggtggagg tcagctggga gtaccctgac      780

acctggagta ctccacattc ctacttctcc ctgacattct gtgttcaagt ccagggcaag      840

agcaagagag aaaagaaaga tagagtcttc actgacaaga cctcagccac agtcatctgc      900

aggaaaaatg ccagcatttc agtgagggcc caggacagat actatagctc atcttggtca      960

gaatgggcat ctgtgccctg cagttga                                          987


<210>  11
<211>  489
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-15 ("wild-type" no CpG modification)

<400>  11
atgagaattt cgaaaccaca tttgagaagt atttccatcc agtgctactt gtgtttactt       60

ctaaacagtc attttctaac tgaagctggc attcatgtct tcattttggg ctgtttctct      120

gcagggcttc ctaaaacaga agccaactgg gtgaatgtaa taagtgattt gaaaaaaatt      180

gaagatctta ttcaatctat gcatattgat gctactttat atacggaaag tgatgttcac      240

cccagttgca aagtaacagc aatgaagtgc tttctcttgg agttacaagt tatttcactt      300

gagtccggag atgcaagtat tcatgataca gtagaaaatc tgatcatcct agcaaacaac      360

agtttgtctt ctaatgggaa tgtaacagaa tctggatgca aagaatgtga ggaactggag      420

gaaaaaaata ttaaagaatt tttgcagagt tttgtacata ttgtccaaat gttcatcaac      480

acttcttga                                                              489


<210>  12
<211>  489
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-15(with CpG modification)

<400>  12
atgagaatta gcaaaccaca tttgagaagt atttccatcc agtgctactt gtgtttactt       60

ctaaacagtc attttctaac tgaagctggc attcatgtct tcattttggg ctgtttctct      120

gcagggcttc ctaaaacaga agccaactgg gtgaatgtaa taagtgattt gaaaaaaatt      180

gaagatctta ttcaatctat gcatattgat gctactttat atactgaaag tgatgttcac      240

cccagttgca aagtaacagc aatgaagtgc tttctcttgg agttacaagt tatttcactt      300

gagagcggag atgcaagtat tcatgataca gtagaaaatc tgatcatcct agcaaacaac      360

agtttgtctt ctaatgggaa tgtaacagaa tctggatgca aagaatgtga ggaactggag      420

gaaaaaaata ttaaagaatt tttgcagagt tttgtacata ttgtccaaat gttcatcaac      480

acttcttga                                                              489


<210>  13
<211>  489
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-15 (with CpG modification)

<400>  13
atgagaatta gcaaaccaca tttgagaagt atttccatcc agtgctactt gtgtttactt       60

ctaaacagtc attttctaac tgaagctggc attcatgtct tcattttggg ctgtttctct      120

gcagggcttc ctaaaacaga agccaactgg gtgaatgtaa taagtgattt gaaaaaaatt      180

gaagatctta ttcaatctat gcatattgat gctactttat atactgaaag tgatgttcac      240

cccagttgca aagtaacagc aatgaagtgc tttctcttgg agttacaagt tatttcactt      300

gagtcaggag atgcaagtat tcatgataca gtagaaaatc tgatcatcct agcaaacaac      360

agtttgtctt ctaatgggaa tgtaacagaa tctggatgca aagaatgtga ggaactggag      420

gaaaaaaata ttaaagaatt tttgcagagt tttgtacata ttgtccaaat gttcatcaac      480

acttcttga                                                              489


<210>  14
<211>  4554
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human EF-1a -wild-type IL-12A/IL-12B/IL-15 - IRES (no CpG 
       modification)

<400>  14
gtcgaccaca caaaaaacca acacacagat ctaatgaaaa taaagatctt ttattggcgc       60

gcctcaactg cagggcacag atgcccattc gctccaagat gagctatagt agcggtcctg      120

ggcccgcacg ctaatgctgg catttttgcg gcagatgacc gtggctgagg tcttgtccgt      180

gaagactcta tctttctttt ctctcttgct cttgccctgg acttgaacgc agaatgtcag      240

ggagaagtag gaatgtggag tactccaggt gtcagggtac tcccagctga cctccacctg      300

ccgagaattc tttaatggct tcagctgcaa gttcttgggt gggtcaggtt tgatgatgtc      360

cctgatgaag aagctgctgg tgtagttttc atacttgagc ttgtgaacgg catccaccat      420

cacctcaatg ggcagactct cctcagcagc tgggcaggca ctgtcctcct ggcactccac      480

tgagtactca tactccttgt tgtcccctct gactctctct gcagagagtg tagcagctcc      540

gcacgtcacc ccttgggggt cagaagagcc tctgctgctt ttgacactga atgtcaaatc      600

agtactgatt gtcgtcagcc accagcaggt gaaacgtcca gaataattct tggcctcgca      660

tcttagaaag gtcttatttt tgggttcttt ctggtccttt aaaatatcag tggaccaaat      720

tccatcttcc tttttgtgaa gcagcaggag cgaatggctt agaacctcgc ctcctttgtg      780

acaggtgtac tggccagcat ctccaaactc tttgacttgg atggtcaggg ttttgccaga      840

gcctaagacc tcactgctct ggtccaaggt ccaggtgata ccatcttctt caggggtgtc      900

acaggtgagg accaccattt ctccaggggc atccggatac caatccaatt ctacgacata      960

aacatctttc ttcagttccc atatggccac gaggggagat gccagaaaaa ccagggaaaa     1020

ccaagagatg accaactgct ggtgacacat ggtggcggcg cgccatttaa atctagcctt     1080

aagagctgta attgaactgg gagtggacac ctgtggagag aaaggcaaag tggatgtcag     1140

taagaccaat aggtgcctat cagaaacgca agagtcttct ctgtctcgac aagcccagtt     1200

tctattggtc tccttaaacc tgtcttgtaa ccttgatact tacctgccca gtgcctcacg     1260

accaacttcg atctgtaacg gcgcagaaca gaaaacgaaa caaagacgta gagttgagca     1320

agcagggtca ggcaaagcgt ggagagccgg ctgagtctag gtaggctcca agggagcgcc     1380

ggacaaaggc ccggtctcga cctgagcttt aaacttacct agacggcgga cgcagttcag     1440

gaggcaccac aggcgggagg cggcagaacg cgactcaacc ggcgtggatg gcggcctcag     1500

gtagggcggc gggcgcgtga aggagagatg cgagcccctc gaagcttcag ctgtgttctg     1560

gcggcaaacc cgttgcgaaa aagaacgttc acggcgacta ctgcacttat atacggttct     1620

cccccaccct cgggaaaaag gcggagccag tacacgacat cactttccca gtttaccccg     1680

cgccaccttc tctaggcacc ggttcaattg ccgacccctc cccccaactt ctcggggact     1740

gtgggcgatg tgcgctctgc ccactgacgg gcaccggagc gatcttaatt aactagttat     1800

taatagtaat caattacggg gtcattagtt catagcccat atatggagtt ccgcgttaca     1860

taacttacgg taaatggccc gcctggctga ccgcccaacg acccccgccc attgacgtca     1920

ataatgacgt atgttcccat agtaacgcca atagggactt tccattgacg tcaatgggtg     1980

gactatttac ggtaaactgc ccacttggca gtacatcaag tgtatcatat gccaagtacg     2040

ccccctattg acgtcaatga cggtaaatgg cccgcctggc attatgccca gtacatgacc     2100

ttatgggact ttcctacttg gcagtacatc tacgtattag tcatcgctat taccatgggt     2160

gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac ggggatttcc     2220

aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt     2280

tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg     2340

ggaggtctat ataagcagag ctcgtttagt gaaccgtcag atcgcctgga gacgtcgagg     2400

aactgaaaaa ccagaaagtt aactggtaag tttagtcttt ttgtctttta tttcaggtcc     2460

cggatccggt ggtggtgcaa atcaaagaac tgctcctcag tggatgttgc ctttacttct     2520

aggcctgtac ggaagtgttt aaacttctgc tctgcggccg cgccaccatg tgtccagcgc     2580

gcagcctcct ccttgtggct accctggtcc tcctggacca cctcagtttg gccagaaacc     2640

tccccgtggc cactccagac ccaggaatgt tcccatgcct tcaccactcc caaaacctgc     2700

tgagggccgt cagcaacatg ctccagaagg ccagacaaac tctagaattt tacccttgca     2760

cttctgaaga gattgatcat gaagatatca caaaagataa aaccagcaca gtggaggcct     2820

gtttaccatt ggaattaacc aagaatgaga gttgcctaaa ttccagagag acctctttca     2880

taactaatgg gagttgcctg gcctccagaa agacctcttt tatgatggcc ctgtgcctta     2940

gtagtattta tgaagacttg aagatgtacc aggtggagtt caagaccatg aatgcaaagc     3000

ttctgatgga tcctaagagg cagatctttc tagatcaaaa catgctggca gttattgatg     3060

agctgatgca ggccctgaat ttcaacagtg agactgtgcc acaaaaatcc tcccttgaag     3120

aaccggattt ttataaaact aaaatcaagc tctgcatact tcttcatgct ttccggattc     3180

gggcagtgac tattgataga gtgatgagct atctgaatgc ttcctgagcc cctctccctc     3240

ccccccccct aacgttactg gccgaagccg cttggaataa ggccggtgtg cgtttgtcta     3300

tatgttattt tccaccatat tgccgtcttt tggcaatgtg agggcccgga aacctggccc     3360

tgtcttcttg acgagcattc ctaggggtct ttcccctctc gccaaaggaa tgcaaggtct     3420

gttgaatgtc gtgaaggaag cagttcctct ggaagcttct tgaagacaaa caacgtctgt     3480

agcgaccctt tgcaggcagc ggaacccccc acctggcgac aggtgcctct gcggccaaaa     3540

gccacgtgta taagatacac ctgcaaaggc ggcacaaccc cagtgccacg ttgtgagttg     3600

gatagttgtg gaaagagtca aatggctctc ctcaagcgta ttcaacaagg ggctgaagga     3660

tgcccagaag gtaccccatt gtatgggatc tgatctgggg cctcggtaca catgctttac     3720

atgtgtttag tcgaggttaa aaaaacgtct aggccccccg aaccacgggg acgtggtttt     3780

cctttgaaaa acacgatgat aatatggcca caatgagaat ttcgaaacca catttgagaa     3840

gtatttccat ccagtgctac ttgtgtttac ttctaaacag tcattttcta actgaagctg     3900

gcattcatgt cttcattttg ggctgtttct ctgcagggct tcctaaaaca gaagccaact     3960

gggtgaatgt aataagtgat ttgaaaaaaa ttgaagatct tattcaatct atgcatattg     4020

atgctacttt atatacggaa agtgatgttc accccagttg caaagtaaca gcaatgaagt     4080

gctttctctt ggagttacaa gttatttcac ttgagtccgg agatgcaagt attcatgata     4140

cagtagaaaa tctgatcatc ctagcaaaca acagtttgtc ttctaatggg aatgtaacag     4200

aatctggatg caaagaatgt gaggaactgg aggaaaaaaa tattaaagaa tttttgcaga     4260

gttttgtaca tattgtccaa atgttcatca acacttcttg agcggccgcg ctagccaatt     4320

gctgtgcctt ctagttgcca gccatctgtt gtttgcccct cccccgtgcc ttccttgacc     4380

ctggaaggtg ccactcccac tgtcctttcc taataaaatg aggaaattgc atcgcattgt     4440

ctgagtaggt gtcattctat tctggggggt ggggtggggc aggacagcaa gggggaggat     4500

tgggaagaca atagcaggca tgctggggat gcggtgggct ctatggagct cgag           4554


<210>  15
<211>  4062
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human EF-1a- wild-type IL-12A/IL-12B/IL-15 - F2A (no CpG 
       modification)

<400>  15
gtcgaccaca caaaaaacca acacacagat ctaatgaaaa taaagatctt ttattggcgc       60

gcctcaagaa gtgttgatga acatttggac aatatgtaca aaactctgca aaaattcttt      120

aatatttttt tcctccagtt cctcacattc tttgcatcca gattctgtta cattcccatt      180

agaagacaaa ctgttgtttg ctaggatgat cagattttct actgtatcat gaatacttgc      240

atctccggac tcaagtgaaa taacttgtaa ctccaagaga aagcacttca ttgctgttac      300

tttgcaactg gggtgaacat cactttccgt atataaagta gcatcaatat gcatagattg      360

aataagatct tcaatttttt tcaaatcact tattacattc acccagttgg cttctgtttt      420

aggaagccct gcagagaaac agcccaaaat gaagacatga atgccagctt cagttagaaa      480

atgactgttt agaagtaaac acaagtagca ctggatggaa atacttctca aatgtggttt      540

cgaaattctc atggtggcgg cgcgccattt aaatctagcc ttaagagctg taattgaact      600

gggagtggac acctgtggag agaaaggcaa agtggatgtc agtaagacca ataggtgcct      660

atcagaaacg caagagtctt ctctgtctcg acaagcccag tttctattgg tctccttaaa      720

cctgtcttgt aaccttgata cttacctgcc cagtgcctca cgaccaactt cgatctgtaa      780

cggcgcagaa cagaaaacga aacaaagacg tagagttgag caagcagggt caggcaaagc      840

gtggagagcc ggctgagtct aggtaggctc caagggagcg ccggacaaag gcccggtctc      900

gacctgagct ttaaacttac ctagacggcg gacgcagttc aggaggcacc acaggcggga      960

ggcggcagaa cgcgactcaa ccggcgtgga tggcggcctc aggtagggcg gcgggcgcgt     1020

gaaggagaga tgcgagcccc tcgaagcttc agctgtgttc tggcggcaaa cccgttgcga     1080

aaaagaacgt tcacggcgac tactgcactt atatacggtt ctcccccacc ctcgggaaaa     1140

aggcggagcc agtacacgac atcactttcc cagtttaccc cgcgccacct tctctaggca     1200

ccggttcaat tgccgacccc tccccccaac ttctcgggga ctgtgggcga tgtgcgctct     1260

gcccactgac gggcaccgga gcgatcttaa ttaactagtt attaatagta atcaattacg     1320

gggtcattag ttcatagccc atatatggag ttccgcgtta cataacttac ggtaaatggc     1380

ccgcctggct gaccgcccaa cgacccccgc ccattgacgt caataatgac gtatgttccc     1440

atagtaacgc caatagggac tttccattga cgtcaatggg tggactattt acggtaaact     1500

gcccacttgg cagtacatca agtgtatcat atgccaagta cgccccctat tgacgtcaat     1560

gacggtaaat ggcccgcctg gcattatgcc cagtacatga ccttatggga ctttcctact     1620

tggcagtaca tctacgtatt agtcatcgct attaccatgg gtgatgcggt tttggcagta     1680

catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga     1740

cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa     1800

ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag     1860

agctcgttta gtgaaccgtc agatcgcctg gagacgtcga ggaactgaaa aaccagaaag     1920

ttaactggta agtttagtct ttttgtcttt tatttcaggt cccggatccg gtggtggtgc     1980

aaatcaaaga actgctcctc agtggatgtt gcctttactt ctaggcctgt acggaagtgt     2040

ttaaacttct gctctgcggc cgcgccacca tgtgtccagc gcgcagcctc ctccttgtgg     2100

ctaccctggt cctcctggac cacctcagtt tggccagaaa cctccccgtg gccactccag     2160

acccaggaat gttcccatgc cttcaccact cccaaaacct gctgagggcc gtcagcaaca     2220

tgctccagaa ggccagacaa actctagaat tttacccttg cacttctgaa gagattgatc     2280

atgaagatat cacaaaagat aaaaccagca cagtggaggc ctgtttacca ttggaattaa     2340

ccaagaatga gagttgccta aattccagag agacctcttt cataactaat gggagttgcc     2400

tggcctccag aaagacctct tttatgatgg ccctgtgcct tagtagtatt tatgaagact     2460

tgaagatgta ccaggtggag ttcaagacca tgaatgcaaa gcttctgatg gatcctaaga     2520

ggcagatctt tctagatcaa aacatgctgg cagttattga tgagctgatg caggccctga     2580

atttcaacag tgagactgtg ccacaaaaat cctcccttga agaaccggat ttttataaaa     2640

ctaaaatcaa gctctgcata cttcttcatg ctttccggat tcgggcagtg actattgata     2700

gagtgatgag ctatctgaat gcttccagaa agagaaggag tggctcagga gcccctgtga     2760

aacagaccct gaactttgac ctcttgaagc ttgctgggga tgtggagtct aatcctggtc     2820

caatgtgtca ccagcagttg gtcatctctt ggttttccct ggtttttctg gcatctcccc     2880

tcgtggccat atgggaactg aagaaagatg tttatgtcgt agaattggat tggtatccgg     2940

atgcccctgg agaaatggtg gtcctcacct gtgacacccc tgaagaagat ggtatcacct     3000

ggaccttgga ccagagcagt gaggtcttag gctctggcaa aaccctgacc atccaagtca     3060

aagagtttgg agatgctggc cagtacacct gtcacaaagg aggcgaggtt ctaagccatt     3120

cgctcctgct gcttcacaaa aaggaagatg gaatttggtc cactgatatt ttaaaggacc     3180

agaaagaacc caaaaataag acctttctaa gatgcgaggc caagaattat tctggacgtt     3240

tcacctgctg gtggctgacg acaatcagta ctgatttgac attcagtgtc aaaagcagca     3300

gaggctcttc tgacccccaa ggggtgacgt gcggagctgc tacactctct gcagagagag     3360

tcagagggga caacaaggag tatgagtact cagtggagtg ccaggaggac agtgcctgcc     3420

cagctgctga ggagagtctg cccattgagg tgatggtgga tgccgttcac aagctcaagt     3480

atgaaaacta caccagcagc ttcttcatca gggacatcat caaacctgac ccacccaaga     3540

acttgcagct gaagccatta aagaattctc ggcaggtgga ggtcagctgg gagtaccctg     3600

acacctggag tactccacat tcctacttct ccctgacatt ctgcgttcaa gtccagggca     3660

agagcaagag agaaaagaaa gatagagtct tcacggacaa gacctcagcc acggtcatct     3720

gccgcaaaaa tgccagcatt agcgtgcggg cccaggaccg ctactatagc tcatcttgga     3780

gcgaatgggc atctgtgccc tgcagttgag cggccgcgct agccaattgc tgtgccttct     3840

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     3900

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     3960

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     4020

agcaggcatg ctggggatgc ggtgggctct atggagctcg ag                        4062


<210>  16
<211>  4554
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human EF-1a - modified IL-12A/IL-12B/IL-15 - IRES (with CpG 
       modification)

<400>  16
gtcgaccaca caaaaaacca acacacagat ctaatgaaaa taaagatctt ttattggcgc       60

gcctcaactg cagggcacag atgcccattc tgaccaagat gagctatagt agcggtcctg      120

ggcccgcact gaaatgctgg catttttgcg gcagatgact gtggctgagg tcttgtcagt      180

gaagactcta tctttctttt ctctcttgct cttgccctgg acttgaacac agaatgtcag      240

ggagaagtag gaatgtggag tactccaggt gtcagggtac tcccagctga cctccacctg      300

cctagaattc tttaatggct tcagctgcaa gttcttgggt gggtcaggtt tgatgatgtc      360

cctgatgaag aagctgctgg tgtagttttc atacttgagc ttgtgaaccg catccaccat      420

cacctcaatg ggcagactct cctcagcagc tgggcaggca ctgtcctcct ggcactccac      480

tgagtactca tactccttgt tgtcccctct gactctctct gcagagagtg tagcagctcc      540

gcatgtcacc ccttgggggt cagaagagcc tctgctgctt ttgacactga atgtcaaatc      600

agtactgatt gtagtcagcc accagcaggt gaaccttcca gaataattct tggcctcaca      660

tcttagaaag gtcttatttt tgggttcttt ctggtccttt aaaatatcag tggaccaaat      720

tccatcttcc tttttgtgaa gcagcaggag ggaatggctt agaacctccc ctcctttgtg      780

acaggtgtac tggccagcat ctccaaactc tttgacttgg atggtcaggg ttttgccaga      840

gcctaagacc tcactgctct ggtccaaggt ccaggtgata ccatcttctt caggggtgtc      900

acaggtgagg accaccattt ctccaggggc atcaggatac caatccaatt ctaccacata      960

aacatctttc ttcagttccc atatggccac aaggggagat gccagaaaaa ccagggaaaa     1020

ccaagagatg accaactgct ggtgacacat ggtggcggcg cgccatttaa atctagcctt     1080

aagagctgta attgaactgg gagtggacac ctgtggagag aaaggcaaag tggatgtcag     1140

taagaccaat aggtgcctat cagaaacgca agagtcttct ctgtctcgac aagcccagtt     1200

tctattggtc tccttaaacc tgtcttgtaa ccttgatact tacctgccca gtgcctcacg     1260

accaacttcg atctgtaacg gcgcagaaca gaaaacgaaa caaagacgta gagttgagca     1320

agcagggtca ggcaaagcgt ggagagccgg ctgagtctag gtaggctcca agggagcgcc     1380

ggacaaaggc ccggtctcga cctgagcttt aaacttacct agacggcgga cgcagttcag     1440

gaggcaccac aggcgggagg cggcagaacg cgactcaacc ggcgtggatg gcggcctcag     1500

gtagggcggc gggcgcgtga aggagagatg cgagcccctc gaagcttcag ctgtgttctg     1560

gcggcaaacc cgttgcgaaa aagaacgttc acggcgacta ctgcacttat atacggttct     1620

cccccaccct cgggaaaaag gcggagccag tacacgacat cactttccca gtttaccccg     1680

cgccaccttc tctaggcacc ggttcaattg ccgacccctc cccccaactt ctcggggact     1740

gtgggcgatg tgcgctctgc ccactgacgg gcaccggagc gatcttaatt aactagttat     1800

taatagtaat caattacggg gtcattagtt catagcccat atatggagtt ccgcgttaca     1860

taacttacgg taaatggccc gcctggctga ccgcccaacg acccccgccc attgacgtca     1920

ataatgacgt atgttcccat agtaacgcca atagggactt tccattgacg tcaatgggtg     1980

gactatttac ggtaaactgc ccacttggca gtacatcaag tgtatcatat gccaagtacg     2040

ccccctattg acgtcaatga cggtaaatgg cccgcctggc attatgccca gtacatgacc     2100

ttatgggact ttcctacttg gcagtacatc tacgtattag tcatcgctat taccatgggt     2160

gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac ggggatttcc     2220

aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt     2280

tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg     2340

ggaggtctat ataagcagag ctcgtttagt gaaccgtcag atcgcctgga gacgtcgagg     2400

aactgaaaaa ccagaaagtt aactggtaag tttagtcttt ttgtctttta tttcaggtcc     2460

cggatccggt ggtggtgcaa atcaaagaac tgctcctcag tggatgttgc ctttacttct     2520

aggcctgtac ggaagtgttt aaacttctgc tctgcggccg cgccaccatg tgtccagcgc     2580

gcagcctcct ccttgtggct accctggtcc tcctggacca cctcagtttg gccagaaacc     2640

tccctgtggc cactccagac ccaggaatgt tcccatgcct tcaccactcc caaaacctgc     2700

tgagggctgt cagcaacatg ctccagaagg ccagacaaac tctagaattt tacccttgca     2760

cttctgaaga gattgatcat gaagatatca caaaagataa aaccagcaca gtggaggcct     2820

gtttaccatt ggaattaacc aagaatgaga gttgcctaaa ttccagagag acctctttca     2880

taactaatgg gagttgcctg gcctccagaa agacctcttt tatgatggcc ctgtgcctta     2940

gtagtattta tgaagacttg aagatgtacc aggtggagtt caagaccatg aatgcaaagc     3000

ttctgatgga tcctaagagg cagatctttc tagatcaaaa catgctggca gttattgatg     3060

agctgatgca ggccctgaat ttcaacagtg agactgtgcc acaaaaatcc tcccttgaag     3120

aacctgattt ttataaaact aaaatcaagc tctgcatact tcttcatgct ttccggattc     3180

gcgcagtgac tattgataga gtgatgagct atctgaatgc ttcctgagcc cctctccctc     3240

ccccccccct aacgttactg gccgaagccg cttggaataa ggccggtgtg cgtttgtcta     3300

tatgttattt tccaccatat tgccgtcttt tggcaatgtg agggcccgga aacctggccc     3360

tgtcttcttg acgagcattc ctaggggtct ttcccctctc gccaaaggaa tgcaaggtct     3420

gttgaatgtc gtgaaggaag cagttcctct ggaagcttct tgaagacaaa caacgtctgt     3480

agcgaccctt tgcaggcagc ggaacccccc acctggcgac aggtgcctct gcggccaaaa     3540

gccacgtgta taagatacac ctgcaaaggc ggcacaaccc cagtgccacg ttgtgagttg     3600

gatagttgtg gaaagagtca aatggctctc ctcaagcgta ttcaacaagg ggctgaagga     3660

tgcccagaag gtaccccatt gtatgggatc tgatctgggg cctcggtaca catgctttac     3720

atgtgtttag tcgaggttaa aaaaacgtct aggccccccg aaccacgggg acgtggtttt     3780

cctttgaaaa acacgatgat aatatggcca caatgagaat tagcaaacca catttgagaa     3840

gtatttccat ccagtgctac ttgtgtttac ttctaaacag tcattttcta actgaagctg     3900

gcattcatgt cttcattttg ggctgtttct ctgcagggct tcctaaaaca gaagccaact     3960

gggtgaatgt aataagtgat ttgaaaaaaa ttgaagatct tattcaatct atgcatattg     4020

atgctacttt atatactgaa agtgatgttc accccagttg caaagtaaca gcaatgaagt     4080

gctttctctt ggagttacaa gttatttcac ttgagagcgg agatgcaagt attcatgata     4140

cagtagaaaa tctgatcatc ctagcaaaca acagtttgtc ttctaatggg aatgtaacag     4200

aatctggatg caaagaatgt gaggaactgg aggaaaaaaa tattaaagaa tttttgcaga     4260

gttttgtaca tattgtccaa atgttcatca acacttcttg agcggccgcg ctagccaatt     4320

gctgtgcctt ctagttgcca gccatctgtt gtttgcccct cccccgtgcc ttccttgacc     4380

ctggaaggtg ccactcccac tgtcctttcc taataaaatg aggaaattgc atcgcattgt     4440

ctgagtaggt gtcattctat tctggggggt ggggtggggc aggacagcaa gggggaggat     4500

tgggaagaca atagcaggca tgctggggat gcggtgggct ctatggagct cgag           4554


<210>  17
<211>  4062
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human EF1a- modified IL-12A/IL-12B/IL-15 - F2A (with CpG 
       modification)

<400>  17
gtcgaccaca caaaaaacca acacacagat ctaatgaaaa taaagatctt ttattggcgc       60

gcctcaagaa gtgttgatga acatttggac aatatgtaca aaactctgca aaaattcttt      120

aatatttttt tcctccagtt cctcacattc tttgcatcca gattctgtta cattcccatt      180

agaagacaaa ctgttgtttg ctaggatgat cagattttct actgtatcat gaatacttgc      240

atctccgctc tcaagtgaaa taacttgtaa ctccaagaga aagcacttca ttgctgttac      300

tttgcaactg gggtgaacat cactttcagt atataaagta gcatcaatat gcatagattg      360

aataagatct tcaatttttt tcaaatcact tattacattc acccagttgg cttctgtttt      420

aggaagccct gcagagaaac agcccaaaat gaagacatga atgccagctt cagttagaaa      480

atgactgttt agaagtaaac acaagtagca ctggatggaa atacttctca aatgtggttt      540

gctaattctc atggtggcgg cgcgccattt aaatctagcc ttaagagctg taattgaact      600

gggagtggac acctgtggag agaaaggcaa agtggatgtc agtaagacca ataggtgcct      660

atcagaaacg caagagtctt ctctgtctcg acaagcccag tttctattgg tctccttaaa      720

cctgtcttgt aaccttgata cttacctgcc cagtgcctca cgaccaactt cgatctgtaa      780

cggcgcagaa cagaaaacga aacaaagacg tagagttgag caagcagggt caggcaaagc      840

gtggagagcc ggctgagtct aggtaggctc caagggagcg ccggacaaag gcccggtctc      900

gacctgagct ttaaacttac ctagacggcg gacgcagttc aggaggcacc acaggcggga      960

ggcggcagaa cgcgactcaa ccggcgtgga tggcggcctc aggtagggcg gcgggcgcgt     1020

gaaggagaga tgcgagcccc tcgaagcttc agctgtgttc tggcggcaaa cccgttgcga     1080

aaaagaacgt tcacggcgac tactgcactt atatacggtt ctcccccacc ctcgggaaaa     1140

aggcggagcc agtacacgac atcactttcc cagtttaccc cgcgccacct tctctaggca     1200

ccggttcaat tgccgacccc tccccccaac ttctcgggga ctgtgggcga tgtgcgctct     1260

gcccactgac gggcaccgga gcgatcttaa ttaactagtt attaatagta atcaattacg     1320

gggtcattag ttcatagccc atatatggag ttccgcgtta cataacttac ggtaaatggc     1380

ccgcctggct gaccgcccaa cgacccccgc ccattgacgt caataatgac gtatgttccc     1440

atagtaacgc caatagggac tttccattga cgtcaatggg tggactattt acggtaaact     1500

gcccacttgg cagtacatca agtgtatcat atgccaagta cgccccctat tgacgtcaat     1560

gacggtaaat ggcccgcctg gcattatgcc cagtacatga ccttatggga ctttcctact     1620

tggcagtaca tctacgtatt agtcatcgct attaccatgg gtgatgcggt tttggcagta     1680

catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga     1740

cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa     1800

ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag     1860

agctcgttta gtgaaccgtc agatcgcctg gagacgtcga ggaactgaaa aaccagaaag     1920

ttaactggta agtttagtct ttttgtcttt tatttcaggt cccggatccg gtggtggtgc     1980

aaatcaaaga actgctcctc agtggatgtt gcctttactt ctaggcctgt acggaagtgt     2040

ttaaacttct gctctgcggc cgcgccacca tgtgtccagc gcgcagcctc ctccttgtgg     2100

ctaccctggt cctcctggac cacctcagtt tggccagaaa cctccctgtg gccactccag     2160

acccaggaat gttcccatgc cttcaccact cccaaaacct gctgagggct gtcagcaaca     2220

tgctccagaa ggccagacaa actctagaat tttacccttg cacttctgaa gagattgatc     2280

atgaagatat cacaaaagat aaaaccagca cagtggaggc ctgtttacca ttggaattaa     2340

ccaagaatga gagttgccta aattccagag agacctcttt cataactaat gggagttgcc     2400

tggcctccag aaagacctct tttatgatgg ccctgtgcct tagtagtatt tatgaagact     2460

tgaagatgta ccaggtggag ttcaagacca tgaatgcaaa gcttctgatg gatcctaaga     2520

ggcagatctt tctagatcaa aacatgctgg cagttattga tgagctgatg caggccctga     2580

atttcaacag tgagactgtg ccacaaaaat cctcccttga agaacctgat ttttataaaa     2640

ctaaaatcaa gctctgcata cttcttcatg ctttccggat tcgcgcagtg actattgata     2700

gagtgatgag ctatctgaat gcttccagaa agagaaggag tggctcagga gcccctgtga     2760

aacagaccct gaactttgac ctcttgaagc ttgctgggga tgtggagtct aatcctggtc     2820

caatgtgtca ccagcagttg gtcatctctt ggttttccct ggtttttctg gcatctcccc     2880

ttgtggccat atgggaactg aagaaagatg tttatgtggt agaattggat tggtatcctg     2940

atgcccctgg agaaatggtg gtcctcacct gtgacacccc tgaagaagat ggtatcacct     3000

ggaccttgga ccagagcagt gaggtcttag gctctggcaa aaccctgacc atccaagtca     3060

aagagtttgg agatgctggc cagtacacct gtcacaaagg aggggaggtt ctaagccatt     3120

ccctcctgct gcttcacaaa aaggaagatg gaatttggtc cactgatatt ttaaaggacc     3180

agaaagaacc caaaaataag acctttctaa gatgtgaggc caagaattat tctggaaggt     3240

tcacctgctg gtggctgact acaatcagta ctgatttgac attcagtgtc aaaagcagca     3300

gaggctcttc tgacccccaa ggggtgacat gcggagctgc tacactctct gcagagagag     3360

tcagagggga caacaaggag tatgagtact cagtggagtg ccaggaggac agtgcctgcc     3420

cagctgctga ggagagtctg cccattgagg tgatggtgga tgcggttcac aagctcaagt     3480

atgaaaacta caccagcagc ttcttcatca gggacatcat caaacctgac ccacccaaga     3540

acttgcagct gaagccatta aagaattcta ggcaggtgga ggtcagctgg gagtaccctg     3600

acacctggag tactccacat tcctacttct ccctgacatt ctgtgttcaa gtccagggca     3660

agagcaagag agaaaagaaa gatagagtct tcactgacaa gacctcagcc acagtcatct     3720

gccgcaaaaa tgccagcatt tcagtgcggg cccaggaccg ctactatagc tcatcttggt     3780

cagaatgggc atctgtgccc tgcagttgag cggccgcgct agccaattgc tgtgccttct     3840

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     3900

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     3960

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     4020

agcaggcatg ctggggatgc ggtgggctct atggagctcg ag                        4062


<210>  18
<211>  4554
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human EF1a - modified IL-12A/IL-12B/IL-15 - IRES (with CpG 
       modification)

<400>  18
gtcgaccaca caaaaaacca acacacagat ctaatgaaaa taaagatctt ttattggcgc       60

gcctcaactg cagggcacag atgcccattc tgaccaagat gagctatagt atctgtcctg      120

ggccctcact gaaatgctgg catttttcct gcagatgact gtggctgagg tcttgtcagt      180

gaagactcta tctttctttt ctctcttgct cttgccctgg acttgaacac agaatgtcag      240

ggagaagtag gaatgtggag tactccaggt gtcagggtac tcccagctga cctccacctg      300

cctagaattc tttaatggct tcagctgcaa gttcttgggt gggtcaggtt tgatgatgtc      360

cctgatgaag aagctgctgg tgtagttttc atacttgagc ttgtgaactg catccaccat      420

cacctcaatg ggcagactct cctcagcagc tgggcaggca ctgtcctcct ggcactccac      480

tgagtactca tactccttgt tgtcccctct gactctctct gcagagagtg tagcagctcc      540

acatgtcacc ccttgggggt cagaagagcc tctgctgctt ttgacactga atgtcaaatc      600

agtactgatt gtagtcagcc accagcaggt gaaccttcca gaataattct tggcctcaca      660

tcttagaaag gtcttatttt tgggttcttt ctggtccttt aaaatatcag tggaccaaat      720

tccatcttcc tttttgtgaa gcagcaggag ggaatggctt agaacctccc ctcctttgtg      780

acaggtgtac tggccagcat ctccaaactc tttgacttgg atggtcaggg ttttgccaga      840

gcctaagacc tcactgctct ggtccaaggt ccaggtgata ccatcttctt caggggtgtc      900

acaggtgagg accaccattt ctccaggggc atcaggatac caatccaatt ctaccacata      960

aacatctttc ttcagttccc atatggccac aaggggagat gccagaaaaa ccagggaaaa     1020

ccaagagatg accaactgct ggtgacacat ggtggcggcg cgccatttaa atctagcctt     1080

aagagctgta attgaactgg gagtggacac ctgtggagag aaaggcaaag tggatgtcag     1140

taagaccaat aggtgcctat cagaaacgca agagtcttct ctgtctcgac aagcccagtt     1200

tctattggtc tccttaaacc tgtcttgtaa ccttgatact tacctgccca gtgcctcacg     1260

accaacttcg atctgtaacg gcgcagaaca gaaaacgaaa caaagacgta gagttgagca     1320

agcagggtca ggcaaagcgt ggagagccgg ctgagtctag gtaggctcca agggagcgcc     1380

ggacaaaggc ccggtctcga cctgagcttt aaacttacct agacggcgga cgcagttcag     1440

gaggcaccac aggcgggagg cggcagaacg cgactcaacc ggcgtggatg gcggcctcag     1500

gtagggcggc gggcgcgtga aggagagatg cgagcccctc gaagcttcag ctgtgttctg     1560

gcggcaaacc cgttgcgaaa aagaacgttc acggcgacta ctgcacttat atacggttct     1620

cccccaccct cgggaaaaag gcggagccag tacacgacat cactttccca gtttaccccg     1680

cgccaccttc tctaggcacc ggttcaattg ccgacccctc cccccaactt ctcggggact     1740

gtgggcgatg tgcgctctgc ccactgacgg gcaccggagc gatcttaatt aactagttat     1800

taatagtaat caattacggg gtcattagtt catagcccat atatggagtt ccgcgttaca     1860

taacttacgg taaatggccc gcctggctga ccgcccaacg acccccgccc attgacgtca     1920

ataatgacgt atgttcccat agtaacgcca atagggactt tccattgacg tcaatgggtg     1980

gactatttac ggtaaactgc ccacttggca gtacatcaag tgtatcatat gccaagtacg     2040

ccccctattg acgtcaatga cggtaaatgg cccgcctggc attatgccca gtacatgacc     2100

ttatgggact ttcctacttg gcagtacatc tacgtattag tcatcgctat taccatgggt     2160

gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac ggggatttcc     2220

aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt     2280

tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg     2340

ggaggtctat ataagcagag ctcgtttagt gaaccgtcag atcgcctgga gacgtcgagg     2400

aactgaaaaa ccagaaagtt aactggtaag tttagtcttt ttgtctttta tttcaggtcc     2460

cggatccggt ggtggtgcaa atcaaagaac tgctcctcag tggatgttgc ctttacttct     2520

aggcctgtac ggaagtgttt aaacttctgc tctgcggccg cgccaccatg tgtccagcta     2580

ggagcctcct ccttgtggct accctggtcc tcctggacca cctcagtttg gccagaaacc     2640

tccctgtggc cactccagac ccaggaatgt tcccatgcct tcaccactcc caaaacctgc     2700

tgagggcagt cagcaacatg ctccagaagg ccagacaaac tctagaattt tacccttgca     2760

cttctgaaga gattgatcat gaagatatca caaaagataa aaccagcaca gtggaggcct     2820

gtttaccatt ggaattaacc aagaatgaga gttgcctaaa ttccagagag acctctttca     2880

taactaatgg gagttgcctg gcctccagaa agacctcttt tatgatggcc ctgtgcctta     2940

gtagtattta tgaagacttg aagatgtacc aggtggagtt caagaccatg aatgcaaagc     3000

ttctgatgga tcctaagagg cagatctttc tagatcaaaa catgctggca gttattgatg     3060

agctgatgca ggccctgaat ttcaacagtg agactgtgcc acaaaaatcc tcccttgaag     3120

aacctgattt ttataaaact aaaatcaagc tctgcatact tcttcatgct ttccggatta     3180

gggcagtgac tattgataga gtgatgagct atctgaatgc ttcctgagcc cctctccctc     3240

ccccccccct aacgttactg gccgaagccg cttggaataa ggccggtgtg cgtttgtcta     3300

tatgttattt tccaccatat tgccgtcttt tggcaatgtg agggcccgga aacctggccc     3360

tgtcttcttg acgagcattc ctaggggtct ttcccctctc gccaaaggaa tgcaaggtct     3420

gttgaatgtc gtgaaggaag cagttcctct ggaagcttct tgaagacaaa caacgtctgt     3480

agcgaccctt tgcaggcagc ggaacccccc acctggcgac aggtgcctct gcggccaaaa     3540

gccacgtgta taagatacac ctgcaaaggc ggcacaaccc cagtgccacg ttgtgagttg     3600

gatagttgtg gaaagagtca aatggctctc ctcaagcgta ttcaacaagg ggctgaagga     3660

tgcccagaag gtaccccatt gtatgggatc tgatctgggg cctcggtaca catgctttac     3720

atgtgtttag tcgaggttaa aaaaacgtct aggccccccg aaccacgggg acgtggtttt     3780

cctttgaaaa acacgatgat aatatggcca caatgagaat tagcaaacca catttgagaa     3840

gtatttccat ccagtgctac ttgtgtttac ttctaaacag tcattttcta actgaagctg     3900

gcattcatgt cttcattttg ggctgtttct ctgcagggct tcctaaaaca gaagccaact     3960

gggtgaatgt aataagtgat ttgaaaaaaa ttgaagatct tattcaatct atgcatattg     4020

atgctacttt atatactgaa agtgatgttc accccagttg caaagtaaca gcaatgaagt     4080

gctttctctt ggagttacaa gttatttcac ttgagtcagg agatgcaagt attcatgata     4140

cagtagaaaa tctgatcatc ctagcaaaca acagtttgtc ttctaatggg aatgtaacag     4200

aatctggatg caaagaatgt gaggaactgg aggaaaaaaa tattaaagaa tttttgcaga     4260

gttttgtaca tattgtccaa atgttcatca acacttcttg agcggccgcg ctagccaatt     4320

gctgtgcctt ctagttgcca gccatctgtt gtttgcccct cccccgtgcc ttccttgacc     4380

ctggaaggtg ccactcccac tgtcctttcc taataaaatg aggaaattgc atcgcattgt     4440

ctgagtaggt gtcattctat tctggggggt ggggtggggc aggacagcaa gggggaggat     4500

tgggaagaca atagcaggca tgctggggat gcggtgggct ctatggagct cgag           4554


<210>  19
<211>  4062
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human EF-1a - modified IL-12A/IL-12B/IL-15 - F2A (with CpG 
       modification)

<400>  19
gtcgaccaca caaaaaacca acacacagat ctaatgaaaa taaagatctt ttattggcgc       60

gcctcaagaa gtgttgatga acatttggac aatatgtaca aaactctgca aaaattcttt      120

aatatttttt tcctccagtt cctcacattc tttgcatcca gattctgtta cattcccatt      180

agaagacaaa ctgttgtttg ctaggatgat cagattttct actgtatcat gaatacttgc      240

atctcctgac tcaagtgaaa taacttgtaa ctccaagaga aagcacttca ttgctgttac      300

tttgcaactg gggtgaacat cactttcagt atataaagta gcatcaatat gcatagattg      360

aataagatct tcaatttttt tcaaatcact tattacattc acccagttgg cttctgtttt      420

aggaagccct gcagagaaac agcccaaaat gaagacatga atgccagctt cagttagaaa      480

atgactgttt agaagtaaac acaagtagca ctggatggaa atacttctca aatgtggttt      540

gctaattctc atggtggcgg cgcgccattt aaatctagcc ttaagagctg taattgaact      600

gggagtggac acctgtggag agaaaggcaa agtggatgtc agtaagacca ataggtgcct      660

atcagaaacg caagagtctt ctctgtctcg acaagcccag tttctattgg tctccttaaa      720

cctgtcttgt aaccttgata cttacctgcc cagtgcctca cgaccaactt cgatctgtaa      780

cggcgcagaa cagaaaacga aacaaagacg tagagttgag caagcagggt caggcaaagc      840

gtggagagcc ggctgagtct aggtaggctc caagggagcg ccggacaaag gcccggtctc      900

gacctgagct ttaaacttac ctagacggcg gacgcagttc aggaggcacc acaggcggga      960

ggcggcagaa cgcgactcaa ccggcgtgga tggcggcctc aggtagggcg gcgggcgcgt     1020

gaaggagaga tgcgagcccc tcgaagcttc agctgtgttc tggcggcaaa cccgttgcga     1080

aaaagaacgt tcacggcgac tactgcactt atatacggtt ctcccccacc ctcgggaaaa     1140

aggcggagcc agtacacgac atcactttcc cagtttaccc cgcgccacct tctctaggca     1200

ccggttcaat tgccgacccc tccccccaac ttctcgggga ctgtgggcga tgtgcgctct     1260

gcccactgac gggcaccgga gcgatcttaa ttaactagtt attaatagta atcaattacg     1320

gggtcattag ttcatagccc atatatggag ttccgcgtta cataacttac ggtaaatggc     1380

ccgcctggct gaccgcccaa cgacccccgc ccattgacgt caataatgac gtatgttccc     1440

atagtaacgc caatagggac tttccattga cgtcaatggg tggactattt acggtaaact     1500

gcccacttgg cagtacatca agtgtatcat atgccaagta cgccccctat tgacgtcaat     1560

gacggtaaat ggcccgcctg gcattatgcc cagtacatga ccttatggga ctttcctact     1620

tggcagtaca tctacgtatt agtcatcgct attaccatgg gtgatgcggt tttggcagta     1680

catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga     1740

cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa     1800

ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag     1860

agctcgttta gtgaaccgtc agatcgcctg gagacgtcga ggaactgaaa aaccagaaag     1920

ttaactggta agtttagtct ttttgtcttt tatttcaggt cccggatccg gtggtggtgc     1980

aaatcaaaga actgctcctc agtggatgtt gcctttactt ctaggcctgt acggaagtgt     2040

ttaaacttct gctctgcggc cgcgccacca tgtgtccagc taggagcctc ctccttgtgg     2100

ctaccctggt cctcctggac cacctcagtt tggccagaaa cctccctgtg gccactccag     2160

acccaggaat gttcccatgc cttcaccact cccaaaacct gctgagggca gtcagcaaca     2220

tgctccagaa ggccagacaa actctagaat tttacccttg cacttctgaa gagattgatc     2280

atgaagatat cacaaaagat aaaaccagca cagtggaggc ctgtttacca ttggaattaa     2340

ccaagaatga gagttgccta aattccagag agacctcttt cataactaat gggagttgcc     2400

tggcctccag aaagacctct tttatgatgg ccctgtgcct tagtagtatt tatgaagact     2460

tgaagatgta ccaggtggag ttcaagacca tgaatgcaaa gcttctgatg gatcctaaga     2520

ggcagatctt tctagatcaa aacatgctgg cagttattga tgagctgatg caggccctga     2580

atttcaacag tgagactgtg ccacaaaaat cctcccttga agaacctgat ttttataaaa     2640

ctaaaatcaa gctctgcata cttcttcatg ctttccggat tagggcagtg actattgata     2700

gagtgatgag ctatctgaat gcttccagaa agagaaggag tggctcagga gcccctgtga     2760

aacagaccct gaactttgac ctcttgaagc ttgctgggga tgtggagtct aatcctggtc     2820

caatgtgtca ccagcagttg gtcatctctt ggttttccct ggtttttctg gcatctcccc     2880

ttgtggccat atgggaactg aagaaagatg tttatgtggt agaattggat tggtatcctg     2940

atgcccctgg agaaatggtg gtcctcacct gtgacacccc tgaagaagat ggtatcacct     3000

ggaccttgga ccagagcagt gaggtcttag gctctggcaa aaccctgacc atccaagtca     3060

aagagtttgg agatgctggc cagtacacct gtcacaaagg aggggaggtt ctaagccatt     3120

ccctcctgct gcttcacaaa aaggaagatg gaatttggtc cactgatatt ttaaaggacc     3180

agaaagaacc caaaaataag acctttctaa gatgtgaggc caagaattat tctggaaggt     3240

tcacctgctg gtggctgact acaatcagta ctgatttgac attcagtgtc aaaagcagca     3300

gaggctcttc tgacccccaa ggggtgacat gtggagctgc tacactctct gcagagagag     3360

tcagagggga caacaaggag tatgagtact cagtggagtg ccaggaggac agtgcctgcc     3420

cagctgctga ggagagtctg cccattgagg tgatggtgga tgcagttcac aagctcaagt     3480

atgaaaacta caccagcagc ttcttcatca gggacatcat caaacctgac ccacccaaga     3540

acttgcagct gaagccatta aagaattcta ggcaggtgga ggtcagctgg gagtaccctg     3600

acacctggag tactccacat tcctacttct ccctgacatt ctgtgttcaa gtccagggca     3660

agagcaagag agaaaagaaa gatagagtct tcactgacaa gacctcagcc acagtcatct     3720

gcaggaaaaa tgccagcatt tcagtgaggg cccaggacag atactatagc tcatcttggt     3780

cagaatgggc atctgtgccc tgcagttgag cggccgcgct agccaattgc tgtgccttct     3840

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     3900

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     3960

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     4020

agcaggcatg ctggggatgc ggtgggctct atggagctcg ag                        4062


<210>  20
<211>  4602
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human EF-1a- wild-type IL-12A/IL-12B/IL-15 - ODN-IRES (no CpG 
       modification)

<400>  20
gtcgactcgt cgttttgtcg ttttgtcgtt cacacaaaaa accaacacac agatctaatg       60

aaaataaaga tcttttattg gcgcgcctca actgcagggc acagatgccc attcgctcca      120

agatgagcta tagtagcggt cctgggcccg cacgctaatg ctggcatttt tgcggcagat      180

gaccgtggct gaggtcttgt ccgtgaagac tctatctttc ttttctctct tgctcttgcc      240

ctggacttga acgcagaatg tcagggagaa gtaggaatgt ggagtactcc aggtgtcagg      300

gtactcccag ctgacctcca cctgccgaga attctttaat ggcttcagct gcaagttctt      360

gggtgggtca ggtttgatga tgtccctgat gaagaagctg ctggtgtagt tttcatactt      420

gagcttgtga acggcatcca ccatcacctc aatgggcaga ctctcctcag cagctgggca      480

ggcactgtcc tcctggcact ccactgagta ctcatactcc ttgttgtccc ctctgactct      540

ctctgcagag agtgtagcag ctccgcacgt caccccttgg gggtcagaag agcctctgct      600

gcttttgaca ctgaatgtca aatcagtact gattgtcgtc agccaccagc aggtgaaacg      660

tccagaataa ttcttggcct cgcatcttag aaaggtctta tttttgggtt ctttctggtc      720

ctttaaaata tcagtggacc aaattccatc ttcctttttg tgaagcagca ggagcgaatg      780

gcttagaacc tcgcctcctt tgtgacaggt gtactggcca gcatctccaa actctttgac      840

ttggatggtc agggttttgc cagagcctaa gacctcactg ctctggtcca aggtccaggt      900

gataccatct tcttcagggg tgtcacaggt gaggaccacc atttctccag gggcatccgg      960

ataccaatcc aattctacga cataaacatc tttcttcagt tcccatatgg ccacgagggg     1020

agatgccaga aaaaccaggg aaaaccaaga gatgaccaac tgctggtgac acatggtggc     1080

ggcgcgccat ttaaatctag ccttaagagc tgtaattgaa ctgggagtgg acacctgtgg     1140

agagaaaggc aaagtggatg tcagtaagac caataggtgc ctatcagaaa cgcaagagtc     1200

ttctctgtct cgacaagccc agtttctatt ggtctcctta aacctgtctt gtaaccttga     1260

tacttacctg cccagtgcct cacgaccaac ttcgatctgt aacggcgcag aacagaaaac     1320

gaaacaaaga cgtagagttg agcaagcagg gtcaggcaaa gcgtggagag ccggctgagt     1380

ctaggtaggc tccaagggag cgccggacaa aggcccggtc tcgacctgag ctttaaactt     1440

acctagacgg cggacgcagt tcaggaggca ccacaggcgg gaggcggcag aacgcgactc     1500

aaccggcgtg gatggcggcc tcaggtaggg cggcgggcgc gtgaaggaga gatgcgagcc     1560

cctcgaagct tcagctgtgt tctggcggca aacccgttgc gaaaaagaac gttcacggcg     1620

actactgcac ttatatacgg ttctccccca ccctcgggaa aaaggcggag ccagtacacg     1680

acatcacttt cccagtttac cccgcgccac cttctctagg caccggttca attgccgacc     1740

cctcccccca acttctcggg gactgtgggc gatgtgcgct ctgcccactg acgggcaccg     1800

gagcgatctt aattaactag ttattaatag taatcaatta cggggtcatt agttcatagc     1860

ccatatatgg agttccgcgt tacataactt acggtaaatg gcccgcctgg ctgaccgccc     1920

aacgaccccc gcccattgac gtcaataatg acgtatgttc ccatagtaac gccaataggg     1980

actttccatt gacgtcaatg ggtggactat ttacggtaaa ctgcccactt ggcagtacat     2040

caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa atggcccgcc     2100

tggcattatg cccagtacat gaccttatgg gactttccta cttggcagta catctacgta     2160

ttagtcatcg ctattaccat gggtgatgcg gttttggcag tacatcaatg ggcgtggata     2220

gcggtttgac tcacggggat ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt     2280

ttggcaccaa aatcaacggg actttccaaa atgtcgtaac aactccgccc cattgacgca     2340

aatgggcggt aggcgtgtac ggtgggaggt ctatataagc agagctcgtt tagtgaaccg     2400

tcagatcgcc tggagacgtc gaggaactga aaaaccagaa agttaactgg taagtttagt     2460

ctttttgtct tttatttcag gtcccggatc cggtggtggt gcaaatcaaa gaactgctcc     2520

tcagtggatg ttgcctttac ttctaggcct gtacggaagt gtttaaactt ctgctctgcg     2580

gccgcgccac catgtgtcca gcgcgcagcc tcctccttgt ggctaccctg gtcctcctgg     2640

accacctcag tttggccaga aacctccccg tggccactcc agacccagga atgttcccat     2700

gccttcacca ctcccaaaac ctgctgaggg ccgtcagcaa catgctccag aaggccagac     2760

aaactctaga attttaccct tgcacttctg aagagattga tcatgaagat atcacaaaag     2820

ataaaaccag cacagtggag gcctgtttac cattggaatt aaccaagaat gagagttgcc     2880

taaattccag agagacctct ttcataacta atgggagttg cctggcctcc agaaagacct     2940

cttttatgat ggccctgtgc cttagtagta tttatgaaga cttgaagatg taccaggtgg     3000

agttcaagac catgaatgca aagcttctga tggatcctaa gaggcagatc tttctagatc     3060

aaaacatgct ggcagttatt gatgagctga tgcaggccct gaatttcaac agtgagactg     3120

tgccacaaaa atcctccctt gaagaaccgg atttttataa aactaaaatc aagctctgca     3180

tacttcttca tgctttccgg attcgggcag tgactattga tagagtgatg agctatctga     3240

atgcttcctg agcccctctc cctccccccc ccctaacgtt actggccgaa gccgcttgga     3300

ataaggccgg tgtgcgtttg tctatatgtt attttccacc atattgccgt cttttggcaa     3360

tgtgagggcc cggaaacctg gccctgtctt cttgacgagc attcctaggg gtctttcccc     3420

tctcgccaaa ggaatgcaag gtctgttgaa tgtcgtgaag gaagcagttc ctctggaagc     3480

ttcttgaaga caaacaacgt ctgtagcgac cctttgcagg cagcggaacc ccccacctgg     3540

cgacaggtgc ctctgcggcc aaaagccacg tgtataagat acacctgcaa aggcggcaca     3600

accccagtgc cacgttgtga gttggatagt tgtggaaaga gtcaaatggc tctcctcaag     3660

cgtattcaac aaggggctga aggatgccca gaaggtaccc cattgtatgg gatctgatct     3720

ggggcctcgg tacacatgct ttacatgtgt ttagtcgagg ttaaaaaaac gtctaggccc     3780

cccgaaccac ggggacgtgg ttttcctttg aaaaacacga tgataatatg gccacaatga     3840

gaatttcgaa accacatttg agaagtattt ccatccagtg ctacttgtgt ttacttctaa     3900

acagtcattt tctaactgaa gctggcattc atgtcttcat tttgggctgt ttctctgcag     3960

ggcttcctaa aacagaagcc aactgggtga atgtaataag tgatttgaaa aaaattgaag     4020

atcttattca atctatgcat attgatgcta ctttatatac ggaaagtgat gttcacccca     4080

gttgcaaagt aacagcaatg aagtgctttc tcttggagtt acaagttatt tcacttgagt     4140

ccggagatgc aagtattcat gatacagtag aaaatctgat catcctagca aacaacagtt     4200

tgtcttctaa tgggaatgta acagaatctg gatgcaaaga atgtgaggaa ctggaggaaa     4260

aaaatattaa agaatttttg cagagttttg tacatattgt ccaaatgttc atcaacactt     4320

cttgagcggc cgcgctagcc aattgctgtg ccttctagtt gccagccatc tgttgtttgc     4380

ccctcccccg tgccttcctt gaccctggaa ggtgccactc ccactgtcct ttcctaataa     4440

aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg gggtggggtg     4500

gggcaggaca gcaaggggga ggattgggaa gacaatagca ggcatgctgg ggatgcggtg     4560

ggctctatgt cgtcgttttg tcgttttgtc gttgagctcg ag                        4602


<210>  21
<211>  4110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human EF-1a - wild-type IL-12A/IL-12B/IL-15 - ODN - F2A (no CpG 
       modification)

<400>  21
gtcgactcgt cgttttgtcg ttttgtcgtt cacacaaaaa accaacacac agatctaatg       60

aaaataaaga tcttttattg gcgcgcctca agaagtgttg atgaacattt ggacaatatg      120

tacaaaactc tgcaaaaatt ctttaatatt tttttcctcc agttcctcac attctttgca      180

tccagattct gttacattcc cattagaaga caaactgttg tttgctagga tgatcagatt      240

ttctactgta tcatgaatac ttgcatctcc ggactcaagt gaaataactt gtaactccaa      300

gagaaagcac ttcattgctg ttactttgca actggggtga acatcacttt ccgtatataa      360

agtagcatca atatgcatag attgaataag atcttcaatt tttttcaaat cacttattac      420

attcacccag ttggcttctg ttttaggaag ccctgcagag aaacagccca aaatgaagac      480

atgaatgcca gcttcagtta gaaaatgact gtttagaagt aaacacaagt agcactggat      540

ggaaatactt ctcaaatgtg gtttcgaaat tctcatggtg gcggcgcgcc atttaaatct      600

agccttaaga gctgtaattg aactgggagt ggacacctgt ggagagaaag gcaaagtgga      660

tgtcagtaag accaataggt gcctatcaga aacgcaagag tcttctctgt ctcgacaagc      720

ccagtttcta ttggtctcct taaacctgtc ttgtaacctt gatacttacc tgcccagtgc      780

ctcacgacca acttcgatct gtaacggcgc agaacagaaa acgaaacaaa gacgtagagt      840

tgagcaagca gggtcaggca aagcgtggag agccggctga gtctaggtag gctccaaggg      900

agcgccggac aaaggcccgg tctcgacctg agctttaaac ttacctagac ggcggacgca      960

gttcaggagg caccacaggc gggaggcggc agaacgcgac tcaaccggcg tggatggcgg     1020

cctcaggtag ggcggcgggc gcgtgaagga gagatgcgag cccctcgaag cttcagctgt     1080

gttctggcgg caaacccgtt gcgaaaaaga acgttcacgg cgactactgc acttatatac     1140

ggttctcccc caccctcggg aaaaaggcgg agccagtaca cgacatcact ttcccagttt     1200

accccgcgcc accttctcta ggcaccggtt caattgccga cccctccccc caacttctcg     1260

gggactgtgg gcgatgtgcg ctctgcccac tgacgggcac cggagcgatc ttaattaact     1320

agttattaat agtaatcaat tacggggtca ttagttcata gcccatatat ggagttccgc     1380

gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg     1440

acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca ttgacgtcaa     1500

tgggtggact atttacggta aactgcccac ttggcagtac atcaagtgta tcatatgcca     1560

agtacgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta tgcccagtac     1620

atgaccttat gggactttcc tacttggcag tacatctacg tattagtcat cgctattacc     1680

atgggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg     1740

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg     1800

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt     1860

acggtgggag gtctatataa gcagagctcg tttagtgaac cgtcagatcg cctggagacg     1920

tcgaggaact gaaaaaccag aaagttaact ggtaagttta gtctttttgt cttttatttc     1980

aggtcccgga tccggtggtg gtgcaaatca aagaactgct cctcagtgga tgttgccttt     2040

acttctaggc ctgtacggaa gtgtttaaac ttctgctctg cggccgcgcc accatgtgtc     2100

cagcgcgcag cctcctcctt gtggctaccc tggtcctcct ggaccacctc agtttggcca     2160

gaaacctccc cgtggccact ccagacccag gaatgttccc atgccttcac cactcccaaa     2220

acctgctgag ggccgtcagc aacatgctcc agaaggccag acaaactcta gaattttacc     2280

cttgcacttc tgaagagatt gatcatgaag atatcacaaa agataaaacc agcacagtgg     2340

aggcctgttt accattggaa ttaaccaaga atgagagttg cctaaattcc agagagacct     2400

ctttcataac taatgggagt tgcctggcct ccagaaagac ctcttttatg atggccctgt     2460

gccttagtag tatttatgaa gacttgaaga tgtaccaggt ggagttcaag accatgaatg     2520

caaagcttct gatggatcct aagaggcaga tctttctaga tcaaaacatg ctggcagtta     2580

ttgatgagct gatgcaggcc ctgaatttca acagtgagac tgtgccacaa aaatcctccc     2640

ttgaagaacc ggatttttat aaaactaaaa tcaagctctg catacttctt catgctttcc     2700

ggattcgggc agtgactatt gatagagtga tgagctatct gaatgcttcc agaaagagaa     2760

ggagtggctc aggagcccct gtgaaacaga ccctgaactt tgacctcttg aagcttgctg     2820

gggatgtgga gtctaatcct ggtccaatgt gtcaccagca gttggtcatc tcttggtttt     2880

ccctggtttt tctggcatct cccctcgtgg ccatatggga actgaagaaa gatgtttatg     2940

tcgtagaatt ggattggtat ccggatgccc ctggagaaat ggtggtcctc acctgtgaca     3000

cccctgaaga agatggtatc acctggacct tggaccagag cagtgaggtc ttaggctctg     3060

gcaaaaccct gaccatccaa gtcaaagagt ttggagatgc tggccagtac acctgtcaca     3120

aaggaggcga ggttctaagc cattcgctcc tgctgcttca caaaaaggaa gatggaattt     3180

ggtccactga tattttaaag gaccagaaag aacccaaaaa taagaccttt ctaagatgcg     3240

aggccaagaa ttattctgga cgtttcacct gctggtggct gacgacaatc agtactgatt     3300

tgacattcag tgtcaaaagc agcagaggct cttctgaccc ccaaggggtg acgtgcggag     3360

ctgctacact ctctgcagag agagtcagag gggacaacaa ggagtatgag tactcagtgg     3420

agtgccagga ggacagtgcc tgcccagctg ctgaggagag tctgcccatt gaggtgatgg     3480

tggatgccgt tcacaagctc aagtatgaaa actacaccag cagcttcttc atcagggaca     3540

tcatcaaacc tgacccaccc aagaacttgc agctgaagcc attaaagaat tctcggcagg     3600

tggaggtcag ctgggagtac cctgacacct ggagtactcc acattcctac ttctccctga     3660

cattctgcgt tcaagtccag ggcaagagca agagagaaaa gaaagataga gtcttcacgg     3720

acaagacctc agccacggtc atctgccgca aaaatgccag cattagcgtg cgggcccagg     3780

accgctacta tagctcatct tggagcgaat gggcatctgt gccctgcagt tgagcggccg     3840

cgctagccaa ttgctgtgcc ttctagttgc cagccatctg ttgtttgccc ctcccccgtg     3900

ccttccttga ccctggaagg tgccactccc actgtccttt cctaataaaa tgaggaaatt     3960

gcatcgcatt gtctgagtag gtgtcattct attctggggg gtggggtggg gcaggacagc     4020

aagggggagg attgggaaga caatagcagg catgctgggg atgcggtggg ctctatgtcg     4080

tcgttttgtc gttttgtcgt tgagctcgag                                      4110


<210>  22
<211>  4408
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human UbC - wild-type IL-12A/IL-12B/IL-15 - IRES (no CpG 
       modification)

<400>  22
gtcgaccaca caaaaaacca acacacagat ctaatgaaaa taaagatctt ttattggcgc       60

gcctcaactg cagggcacag atgcccattc gctccaagat gagctatagt agcggtcctg      120

ggcccgcacg ctaatgctgg catttttgcg gcagatgacc gtggctgagg tcttgtccgt      180

gaagactcta tctttctttt ctctcttgct cttgccctgg acttgaacgc agaatgtcag      240

ggagaagtag gaatgtggag tactccaggt gtcagggtac tcccagctga cctccacctg      300

ccgagaattc tttaatggct tcagctgcaa gttcttgggt gggtcaggtt tgatgatgtc      360

cctgatgaag aagctgctgg tgtagttttc atacttgagc ttgtgaacgg catccaccat      420

cacctcaatg ggcagactct cctcagcagc tgggcaggca ctgtcctcct ggcactccac      480

tgagtactca tactccttgt tgtcccctct gactctctct gcagagagtg tagcagctcc      540

gcacgtcacc ccttgggggt cagaagagcc tctgctgctt ttgacactga atgtcaaatc      600

agtactgatt gtcgtcagcc accagcaggt gaaacgtcca gaataattct tggcctcgca      660

tcttagaaag gtcttatttt tgggttcttt ctggtccttt aaaatatcag tggaccaaat      720

tccatcttcc tttttgtgaa gcagcaggag cgaatggctt agaacctcgc ctcctttgtg      780

acaggtgtac tggccagcat ctccaaactc tttgacttgg atggtcaggg ttttgccaga      840

gcctaagacc tcactgctct ggtccaaggt ccaggtgata ccatcttctt caggggtgtc      900

acaggtgagg accaccattt ctccaggggc atccggatac caatccaatt ctacgacata      960

aacatctttc ttcagttccc atatggccac gaggggagat gccagaaaaa ccagggaaaa     1020

ccaagagatg accaactgct ggtgacacat ggtggcggcg cgccatttaa atctagcctt     1080

aagagctgta attgaactgg gagtggacac ctgtggagag aaaggcaaag tggatgtcag     1140

taagaccaat aggtgcctat cagaaacgca agagtcttct ctgtctcgac aagcccagtt     1200

tctattggtc tccttaaacc tgtcttgtaa ccttgatact tacctgccca gtgcctcacg     1260

accaacttca gaactgcgac ccaaatcccg gctgcgacgg aactagctgt gccacacccg     1320

gcgcgtcctt atataatcat cggcgttcac cgccccacgg agatccctcc gcagaatcgc     1380

cgagaaggga ctacttttcc tcgcctgttc cgctctctgg aaagaaaacc agtgccctag     1440

agtcacccaa gtcccgtcct aaaatgtcct tctgctgata ctggggttct aaggccgagt     1500

cttatgagca gcgggccgct gtcctgagcg tccgggcgga aggatcagga cgctcgctgc     1560

gcccttcgtc tgacgtggca gcgctcgccg tgaggagggg ggcgcccgcg ggaggcgcca     1620

aaacccggcg cggaggcctt aattaactag ttattaatag taatcaatta cggggtcatt     1680

agttcatagc ccatatatgg agttccgcgt tacataactt acggtaaatg gcccgcctgg     1740

ctgaccgccc aacgaccccc gcccattgac gtcaataatg acgtatgttc ccatagtaac     1800

gccaataggg actttccatt gacgtcaatg ggtggactat ttacggtaaa ctgcccactt     1860

ggcagtacat caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa     1920

atggcccgcc tggcattatg cccagtacat gaccttatgg gactttccta cttggcagta     1980

catctacgta ttagtcatcg ctattaccat gggtgatgcg gttttggcag tacatcaatg     2040

ggcgtggata gcggtttgac tcacggggat ttccaagtct ccaccccatt gacgtcaatg     2100

ggagtttgtt ttggcaccaa aatcaacggg actttccaaa atgtcgtaac aactccgccc     2160

cattgacgca aatgggcggt aggcgtgtac ggtgggaggt ctatataagc agagctcgtt     2220

tagtgaaccg tcagatcgcc tggagacgtc gaggaactga aaaaccagaa agttaactgg     2280

taagtttagt ctttttgtct tttatttcag gtcccggatc cggtggtggt gcaaatcaaa     2340

gaactgctcc tcagtggatg ttgcctttac ttctaggcct gtacggaagt gtttaaactt     2400

ctgctctgcg gccgcgccac catgtgtcca gcgcgcagcc tcctccttgt ggctaccctg     2460

gtcctcctgg accacctcag tttggccaga aacctccccg tggccactcc agacccagga     2520

atgttcccat gccttcacca ctcccaaaac ctgctgaggg ccgtcagcaa catgctccag     2580

aaggccagac aaactctaga attttaccct tgcacttctg aagagattga tcatgaagat     2640

atcacaaaag ataaaaccag cacagtggag gcctgtttac cattggaatt aaccaagaat     2700

gagagttgcc taaattccag agagacctct ttcataacta atgggagttg cctggcctcc     2760

agaaagacct cttttatgat ggccctgtgc cttagtagta tttatgaaga cttgaagatg     2820

taccaggtgg agttcaagac catgaatgca aagcttctga tggatcctaa gaggcagatc     2880

tttctagatc aaaacatgct ggcagttatt gatgagctga tgcaggccct gaatttcaac     2940

agtgagactg tgccacaaaa atcctccctt gaagaaccgg atttttataa aactaaaatc     3000

aagctctgca tacttcttca tgctttccgg attcgggcag tgactattga tagagtgatg     3060

agctatctga atgcttcctg agcccctctc cctccccccc ccctaacgtt actggccgaa     3120

gccgcttgga ataaggccgg tgtgcgtttg tctatatgtt attttccacc atattgccgt     3180

cttttggcaa tgtgagggcc cggaaacctg gccctgtctt cttgacgagc attcctaggg     3240

gtctttcccc tctcgccaaa ggaatgcaag gtctgttgaa tgtcgtgaag gaagcagttc     3300

ctctggaagc ttcttgaaga caaacaacgt ctgtagcgac cctttgcagg cagcggaacc     3360

ccccacctgg cgacaggtgc ctctgcggcc aaaagccacg tgtataagat acacctgcaa     3420

aggcggcaca accccagtgc cacgttgtga gttggatagt tgtggaaaga gtcaaatggc     3480

tctcctcaag cgtattcaac aaggggctga aggatgccca gaaggtaccc cattgtatgg     3540

gatctgatct ggggcctcgg tacacatgct ttacatgtgt ttagtcgagg ttaaaaaaac     3600

gtctaggccc cccgaaccac ggggacgtgg ttttcctttg aaaaacacga tgataatatg     3660

gccacaatga gaatttcgaa accacatttg agaagtattt ccatccagtg ctacttgtgt     3720

ttacttctaa acagtcattt tctaactgaa gctggcattc atgtcttcat tttgggctgt     3780

ttctctgcag ggcttcctaa aacagaagcc aactgggtga atgtaataag tgatttgaaa     3840

aaaattgaag atcttattca atctatgcat attgatgcta ctttatatac ggaaagtgat     3900

gttcacccca gttgcaaagt aacagcaatg aagtgctttc tcttggagtt acaagttatt     3960

tcacttgagt ccggagatgc aagtattcat gatacagtag aaaatctgat catcctagca     4020

aacaacagtt tgtcttctaa tgggaatgta acagaatctg gatgcaaaga atgtgaggaa     4080

ctggaggaaa aaaatattaa agaatttttg cagagttttg tacatattgt ccaaatgttc     4140

atcaacactt cttgagcggc cgcgctagcc aattgctgtg ccttctagtt gccagccatc     4200

tgttgtttgc ccctcccccg tgccttcctt gaccctggaa ggtgccactc ccactgtcct     4260

ttcctaataa aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg     4320

gggtggggtg gggcaggaca gcaaggggga ggattgggaa gacaatagca ggcatgctgg     4380

ggatgcggtg ggctctatgg agctcgag                                        4408


<210>  23
<211>  3916
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human UbC - wild-type IL-12A/IL-12B/IL-15 - F2A (no CpG 
       modification)

<400>  23
gtcgaccaca caaaaaacca acacacagat ctaatgaaaa taaagatctt ttattggcgc       60

gcctcaagaa gtgttgatga acatttggac aatatgtaca aaactctgca aaaattcttt      120

aatatttttt tcctccagtt cctcacattc tttgcatcca gattctgtta cattcccatt      180

agaagacaaa ctgttgtttg ctaggatgat cagattttct actgtatcat gaatacttgc      240

atctccggac tcaagtgaaa taacttgtaa ctccaagaga aagcacttca ttgctgttac      300

tttgcaactg gggtgaacat cactttccgt atataaagta gcatcaatat gcatagattg      360

aataagatct tcaatttttt tcaaatcact tattacattc acccagttgg cttctgtttt      420

aggaagccct gcagagaaac agcccaaaat gaagacatga atgccagctt cagttagaaa      480

atgactgttt agaagtaaac acaagtagca ctggatggaa atacttctca aatgtggttt      540

cgaaattctc atggtggcgg cgcgccattt aaatctagcc ttaagagctg taattgaact      600

gggagtggac acctgtggag agaaaggcaa agtggatgtc agtaagacca ataggtgcct      660

atcagaaacg caagagtctt ctctgtctcg acaagcccag tttctattgg tctccttaaa      720

cctgtcttgt aaccttgata cttacctgcc cagtgcctca cgaccaactt cagaactgcg      780

acccaaatcc cggctgcgac ggaactagct gtgccacacc cggcgcgtcc ttatataatc      840

atcggcgttc accgccccac ggagatccct ccgcagaatc gccgagaagg gactactttt      900

cctcgcctgt tccgctctct ggaaagaaaa ccagtgccct agagtcaccc aagtcccgtc      960

ctaaaatgtc cttctgctga tactggggtt ctaaggccga gtcttatgag cagcgggccg     1020

ctgtcctgag cgtccgggcg gaaggatcag gacgctcgct gcgcccttcg tctgacgtgg     1080

cagcgctcgc cgtgaggagg ggggcgcccg cgggaggcgc caaaacccgg cgcggaggcc     1140

ttaattaact agttattaat agtaatcaat tacggggtca ttagttcata gcccatatat     1200

ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc     1260

ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca     1320

ttgacgtcaa tgggtggact atttacggta aactgcccac ttggcagtac atcaagtgta     1380

tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta     1440

tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg tattagtcat     1500

cgctattacc atgggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg     1560

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc     1620

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg     1680

gtaggcgtgt acggtgggag gtctatataa gcagagctcg tttagtgaac cgtcagatcg     1740

cctggagacg tcgaggaact gaaaaaccag aaagttaact ggtaagttta gtctttttgt     1800

cttttatttc aggtcccgga tccggtggtg gtgcaaatca aagaactgct cctcagtgga     1860

tgttgccttt acttctaggc ctgtacggaa gtgtttaaac ttctgctctg cggccgcgcc     1920

accatgtgtc cagcgcgcag cctcctcctt gtggctaccc tggtcctcct ggaccacctc     1980

agtttggcca gaaacctccc cgtggccact ccagacccag gaatgttccc atgccttcac     2040

cactcccaaa acctgctgag ggccgtcagc aacatgctcc agaaggccag acaaactcta     2100

gaattttacc cttgcacttc tgaagagatt gatcatgaag atatcacaaa agataaaacc     2160

agcacagtgg aggcctgttt accattggaa ttaaccaaga atgagagttg cctaaattcc     2220

agagagacct ctttcataac taatgggagt tgcctggcct ccagaaagac ctcttttatg     2280

atggccctgt gccttagtag tatttatgaa gacttgaaga tgtaccaggt ggagttcaag     2340

accatgaatg caaagcttct gatggatcct aagaggcaga tctttctaga tcaaaacatg     2400

ctggcagtta ttgatgagct gatgcaggcc ctgaatttca acagtgagac tgtgccacaa     2460

aaatcctccc ttgaagaacc ggatttttat aaaactaaaa tcaagctctg catacttctt     2520

catgctttcc ggattcgggc agtgactatt gatagagtga tgagctatct gaatgcttcc     2580

agaaagagaa ggagtggctc aggagcccct gtgaaacaga ccctgaactt tgacctcttg     2640

aagcttgctg gggatgtgga gtctaatcct ggtccaatgt gtcaccagca gttggtcatc     2700

tcttggtttt ccctggtttt tctggcatct cccctcgtgg ccatatggga actgaagaaa     2760

gatgtttatg tcgtagaatt ggattggtat ccggatgccc ctggagaaat ggtggtcctc     2820

acctgtgaca cccctgaaga agatggtatc acctggacct tggaccagag cagtgaggtc     2880

ttaggctctg gcaaaaccct gaccatccaa gtcaaagagt ttggagatgc tggccagtac     2940

acctgtcaca aaggaggcga ggttctaagc cattcgctcc tgctgcttca caaaaaggaa     3000

gatggaattt ggtccactga tattttaaag gaccagaaag aacccaaaaa taagaccttt     3060

ctaagatgcg aggccaagaa ttattctgga cgtttcacct gctggtggct gacgacaatc     3120

agtactgatt tgacattcag tgtcaaaagc agcagaggct cttctgaccc ccaaggggtg     3180

acgtgcggag ctgctacact ctctgcagag agagtcagag gggacaacaa ggagtatgag     3240

tactcagtgg agtgccagga ggacagtgcc tgcccagctg ctgaggagag tctgcccatt     3300

gaggtgatgg tggatgccgt tcacaagctc aagtatgaaa actacaccag cagcttcttc     3360

atcagggaca tcatcaaacc tgacccaccc aagaacttgc agctgaagcc attaaagaat     3420

tctcggcagg tggaggtcag ctgggagtac cctgacacct ggagtactcc acattcctac     3480

ttctccctga cattctgcgt tcaagtccag ggcaagagca agagagaaaa gaaagataga     3540

gtcttcacgg acaagacctc agccacggtc atctgccgca aaaatgccag cattagcgtg     3600

cgggcccagg accgctacta tagctcatct tggagcgaat gggcatctgt gccctgcagt     3660

tgagcggccg cgctagccaa ttgctgtgcc ttctagttgc cagccatctg ttgtttgccc     3720

ctcccccgtg ccttccttga ccctggaagg tgccactccc actgtccttt cctaataaaa     3780

tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct attctggggg gtggggtggg     3840

gcaggacagc aagggggagg attgggaaga caatagcagg catgctgggg atgcggtggg     3900

ctctatggag ctcgag                                                     3916


<210>  24
<211>  4408
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human UbC - modified IL-12A/IL-12B/IL-15 - IRES (with CpG 
       modification)

<400>  24
gtcgaccaca caaaaaacca acacacagat ctaatgaaaa taaagatctt ttattggcgc       60

gcctcaactg cagggcacag atgcccattc tgaccaagat gagctatagt agcggtcctg      120

ggcccgcact gaaatgctgg catttttgcg gcagatgact gtggctgagg tcttgtcagt      180

gaagactcta tctttctttt ctctcttgct cttgccctgg acttgaacac agaatgtcag      240

ggagaagtag gaatgtggag tactccaggt gtcagggtac tcccagctga cctccacctg      300

cctagaattc tttaatggct tcagctgcaa gttcttgggt gggtcaggtt tgatgatgtc      360

cctgatgaag aagctgctgg tgtagttttc atacttgagc ttgtgaaccg catccaccat      420

cacctcaatg ggcagactct cctcagcagc tgggcaggca ctgtcctcct ggcactccac      480

tgagtactca tactccttgt tgtcccctct gactctctct gcagagagtg tagcagctcc      540

gcatgtcacc ccttgggggt cagaagagcc tctgctgctt ttgacactga atgtcaaatc      600

agtactgatt gtagtcagcc accagcaggt gaaccttcca gaataattct tggcctcaca      660

tcttagaaag gtcttatttt tgggttcttt ctggtccttt aaaatatcag tggaccaaat      720

tccatcttcc tttttgtgaa gcagcaggag ggaatggctt agaacctccc ctcctttgtg      780

acaggtgtac tggccagcat ctccaaactc tttgacttgg atggtcaggg ttttgccaga      840

gcctaagacc tcactgctct ggtccaaggt ccaggtgata ccatcttctt caggggtgtc      900

acaggtgagg accaccattt ctccaggggc atcaggatac caatccaatt ctaccacata      960

aacatctttc ttcagttccc atatggccac aaggggagat gccagaaaaa ccagggaaaa     1020

ccaagagatg accaactgct ggtgacacat ggtggcggcg cgccatttaa atctagcctt     1080

aagagctgta attgaactgg gagtggacac ctgtggagag aaaggcaaag tggatgtcag     1140

taagaccaat aggtgcctat cagaaacgca agagtcttct ctgtctcgac aagcccagtt     1200

tctattggtc tccttaaacc tgtcttgtaa ccttgatact tacctgccca gtgcctcacg     1260

accaacttca gaactgcgac ccaaatcccg gctgcgacgg aactagctgt gccacacccg     1320

gcgcgtcctt atataatcat cggcgttcac cgccccacgg agatccctcc gcagaatcgc     1380

cgagaaggga ctacttttcc tcgcctgttc cgctctctgg aaagaaaacc agtgccctag     1440

agtcacccaa gtcccgtcct aaaatgtcct tctgctgata ctggggttct aaggccgagt     1500

cttatgagca gcgggccgct gtcctgagcg tccgggcgga aggatcagga cgctcgctgc     1560

gcccttcgtc tgacgtggca gcgctcgccg tgaggagggg ggcgcccgcg ggaggcgcca     1620

aaacccggcg cggaggcctt aattaactag ttattaatag taatcaatta cggggtcatt     1680

agttcatagc ccatatatgg agttccgcgt tacataactt acggtaaatg gcccgcctgg     1740

ctgaccgccc aacgaccccc gcccattgac gtcaataatg acgtatgttc ccatagtaac     1800

gccaataggg actttccatt gacgtcaatg ggtggactat ttacggtaaa ctgcccactt     1860

ggcagtacat caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa     1920

atggcccgcc tggcattatg cccagtacat gaccttatgg gactttccta cttggcagta     1980

catctacgta ttagtcatcg ctattaccat gggtgatgcg gttttggcag tacatcaatg     2040

ggcgtggata gcggtttgac tcacggggat ttccaagtct ccaccccatt gacgtcaatg     2100

ggagtttgtt ttggcaccaa aatcaacggg actttccaaa atgtcgtaac aactccgccc     2160

cattgacgca aatgggcggt aggcgtgtac ggtgggaggt ctatataagc agagctcgtt     2220

tagtgaaccg tcagatcgcc tggagacgtc gaggaactga aaaaccagaa agttaactgg     2280

taagtttagt ctttttgtct tttatttcag gtcccggatc cggtggtggt gcaaatcaaa     2340

gaactgctcc tcagtggatg ttgcctttac ttctaggcct gtacggaagt gtttaaactt     2400

ctgctctgcg gccgcgccac catgtgtcca gcgcgcagcc tcctccttgt ggctaccctg     2460

gtcctcctgg accacctcag tttggccaga aacctccctg tggccactcc agacccagga     2520

atgttcccat gccttcacca ctcccaaaac ctgctgaggg ctgtcagcaa catgctccag     2580

aaggccagac aaactctaga attttaccct tgcacttctg aagagattga tcatgaagat     2640

atcacaaaag ataaaaccag cacagtggag gcctgtttac cattggaatt aaccaagaat     2700

gagagttgcc taaattccag agagacctct ttcataacta atgggagttg cctggcctcc     2760

agaaagacct cttttatgat ggccctgtgc cttagtagta tttatgaaga cttgaagatg     2820

taccaggtgg agttcaagac catgaatgca aagcttctga tggatcctaa gaggcagatc     2880

tttctagatc aaaacatgct ggcagttatt gatgagctga tgcaggccct gaatttcaac     2940

agtgagactg tgccacaaaa atcctccctt gaagaacctg atttttataa aactaaaatc     3000

aagctctgca tacttcttca tgctttccgg attcgcgcag tgactattga tagagtgatg     3060

agctatctga atgcttcctg agcccctctc cctccccccc ccctaacgtt actggccgaa     3120

gccgcttgga ataaggccgg tgtgcgtttg tctatatgtt attttccacc atattgccgt     3180

cttttggcaa tgtgagggcc cggaaacctg gccctgtctt cttgacgagc attcctaggg     3240

gtctttcccc tctcgccaaa ggaatgcaag gtctgttgaa tgtcgtgaag gaagcagttc     3300

ctctggaagc ttcttgaaga caaacaacgt ctgtagcgac cctttgcagg cagcggaacc     3360

ccccacctgg cgacaggtgc ctctgcggcc aaaagccacg tgtataagat acacctgcaa     3420

aggcggcaca accccagtgc cacgttgtga gttggatagt tgtggaaaga gtcaaatggc     3480

tctcctcaag cgtattcaac aaggggctga aggatgccca gaaggtaccc cattgtatgg     3540

gatctgatct ggggcctcgg tacacatgct ttacatgtgt ttagtcgagg ttaaaaaaac     3600

gtctaggccc cccgaaccac ggggacgtgg ttttcctttg aaaaacacga tgataatatg     3660

gccacaatga gaattagcaa accacatttg agaagtattt ccatccagtg ctacttgtgt     3720

ttacttctaa acagtcattt tctaactgaa gctggcattc atgtcttcat tttgggctgt     3780

ttctctgcag ggcttcctaa aacagaagcc aactgggtga atgtaataag tgatttgaaa     3840

aaaattgaag atcttattca atctatgcat attgatgcta ctttatatac tgaaagtgat     3900

gttcacccca gttgcaaagt aacagcaatg aagtgctttc tcttggagtt acaagttatt     3960

tcacttgaga gcggagatgc aagtattcat gatacagtag aaaatctgat catcctagca     4020

aacaacagtt tgtcttctaa tgggaatgta acagaatctg gatgcaaaga atgtgaggaa     4080

ctggaggaaa aaaatattaa agaatttttg cagagttttg tacatattgt ccaaatgttc     4140

atcaacactt cttgagcggc cgcgctagcc aattgctgtg ccttctagtt gccagccatc     4200

tgttgtttgc ccctcccccg tgccttcctt gaccctggaa ggtgccactc ccactgtcct     4260

ttcctaataa aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg     4320

gggtggggtg gggcaggaca gcaaggggga ggattgggaa gacaatagca ggcatgctgg     4380

ggatgcggtg ggctctatgg agctcgag                                        4408


<210>  25
<211>  3916
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human UbC -modified IL-12A/IL-12B/IL-15 - F2A (with CpG 
       modification)

<400>  25
gtcgaccaca caaaaaacca acacacagat ctaatgaaaa taaagatctt ttattggcgc       60

gcctcaagaa gtgttgatga acatttggac aatatgtaca aaactctgca aaaattcttt      120

aatatttttt tcctccagtt cctcacattc tttgcatcca gattctgtta cattcccatt      180

agaagacaaa ctgttgtttg ctaggatgat cagattttct actgtatcat gaatacttgc      240

atctccgctc tcaagtgaaa taacttgtaa ctccaagaga aagcacttca ttgctgttac      300

tttgcaactg gggtgaacat cactttcagt atataaagta gcatcaatat gcatagattg      360

aataagatct tcaatttttt tcaaatcact tattacattc acccagttgg cttctgtttt      420

aggaagccct gcagagaaac agcccaaaat gaagacatga atgccagctt cagttagaaa      480

atgactgttt agaagtaaac acaagtagca ctggatggaa atacttctca aatgtggttt      540

gctaattctc atggtggcgg cgcgccattt aaatctagcc ttaagagctg taattgaact      600

gggagtggac acctgtggag agaaaggcaa agtggatgtc agtaagacca ataggtgcct      660

atcagaaacg caagagtctt ctctgtctcg acaagcccag tttctattgg tctccttaaa      720

cctgtcttgt aaccttgata cttacctgcc cagtgcctca cgaccaactt cagaactgcg      780

acccaaatcc cggctgcgac ggaactagct gtgccacacc cggcgcgtcc ttatataatc      840

atcggcgttc accgccccac ggagatccct ccgcagaatc gccgagaagg gactactttt      900

cctcgcctgt tccgctctct ggaaagaaaa ccagtgccct agagtcaccc aagtcccgtc      960

ctaaaatgtc cttctgctga tactggggtt ctaaggccga gtcttatgag cagcgggccg     1020

ctgtcctgag cgtccgggcg gaaggatcag gacgctcgct gcgcccttcg tctgacgtgg     1080

cagcgctcgc cgtgaggagg ggggcgcccg cgggaggcgc caaaacccgg cgcggaggcc     1140

ttaattaact agttattaat agtaatcaat tacggggtca ttagttcata gcccatatat     1200

ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc     1260

ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca     1320

ttgacgtcaa tgggtggact atttacggta aactgcccac ttggcagtac atcaagtgta     1380

tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta     1440

tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg tattagtcat     1500

cgctattacc atgggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg     1560

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc     1620

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg     1680

gtaggcgtgt acggtgggag gtctatataa gcagagctcg tttagtgaac cgtcagatcg     1740

cctggagacg tcgaggaact gaaaaaccag aaagttaact ggtaagttta gtctttttgt     1800

cttttatttc aggtcccgga tccggtggtg gtgcaaatca aagaactgct cctcagtgga     1860

tgttgccttt acttctaggc ctgtacggaa gtgtttaaac ttctgctctg cggccgcgcc     1920

accatgtgtc cagcgcgcag cctcctcctt gtggctaccc tggtcctcct ggaccacctc     1980

agtttggcca gaaacctccc tgtggccact ccagacccag gaatgttccc atgccttcac     2040

cactcccaaa acctgctgag ggctgtcagc aacatgctcc agaaggccag acaaactcta     2100

gaattttacc cttgcacttc tgaagagatt gatcatgaag atatcacaaa agataaaacc     2160

agcacagtgg aggcctgttt accattggaa ttaaccaaga atgagagttg cctaaattcc     2220

agagagacct ctttcataac taatgggagt tgcctggcct ccagaaagac ctcttttatg     2280

atggccctgt gccttagtag tatttatgaa gacttgaaga tgtaccaggt ggagttcaag     2340

accatgaatg caaagcttct gatggatcct aagaggcaga tctttctaga tcaaaacatg     2400

ctggcagtta ttgatgagct gatgcaggcc ctgaatttca acagtgagac tgtgccacaa     2460

aaatcctccc ttgaagaacc tgatttttat aaaactaaaa tcaagctctg catacttctt     2520

catgctttcc ggattcgcgc agtgactatt gatagagtga tgagctatct gaatgcttcc     2580

agaaagagaa ggagtggctc aggagcccct gtgaaacaga ccctgaactt tgacctcttg     2640

aagcttgctg gggatgtgga gtctaatcct ggtccaatgt gtcaccagca gttggtcatc     2700

tcttggtttt ccctggtttt tctggcatct ccccttgtgg ccatatggga actgaagaaa     2760

gatgtttatg tggtagaatt ggattggtat cctgatgccc ctggagaaat ggtggtcctc     2820

acctgtgaca cccctgaaga agatggtatc acctggacct tggaccagag cagtgaggtc     2880

ttaggctctg gcaaaaccct gaccatccaa gtcaaagagt ttggagatgc tggccagtac     2940

acctgtcaca aaggagggga ggttctaagc cattccctcc tgctgcttca caaaaaggaa     3000

gatggaattt ggtccactga tattttaaag gaccagaaag aacccaaaaa taagaccttt     3060

ctaagatgtg aggccaagaa ttattctgga aggttcacct gctggtggct gactacaatc     3120

agtactgatt tgacattcag tgtcaaaagc agcagaggct cttctgaccc ccaaggggtg     3180

acatgcggag ctgctacact ctctgcagag agagtcagag gggacaacaa ggagtatgag     3240

tactcagtgg agtgccagga ggacagtgcc tgcccagctg ctgaggagag tctgcccatt     3300

gaggtgatgg tggatgcggt tcacaagctc aagtatgaaa actacaccag cagcttcttc     3360

atcagggaca tcatcaaacc tgacccaccc aagaacttgc agctgaagcc attaaagaat     3420

tctaggcagg tggaggtcag ctgggagtac cctgacacct ggagtactcc acattcctac     3480

ttctccctga cattctgtgt tcaagtccag ggcaagagca agagagaaaa gaaagataga     3540

gtcttcactg acaagacctc agccacagtc atctgccgca aaaatgccag catttcagtg     3600

cgggcccagg accgctacta tagctcatct tggtcagaat gggcatctgt gccctgcagt     3660

tgagcggccg cgctagccaa ttgctgtgcc ttctagttgc cagccatctg ttgtttgccc     3720

ctcccccgtg ccttccttga ccctggaagg tgccactccc actgtccttt cctaataaaa     3780

tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct attctggggg gtggggtggg     3840

gcaggacagc aagggggagg attgggaaga caatagcagg catgctgggg atgcggtggg     3900

ctctatggag ctcgag                                                     3916


<210>  26
<211>  4408
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human UbC - modified IL-12A/IL-12B/IL-15 - IRES (with CpG 
       modification)

<400>  26
gtcgaccaca caaaaaacca acacacagat ctaatgaaaa taaagatctt ttattggcgc       60

gcctcaactg cagggcacag atgcccattc tgaccaagat gagctatagt atctgtcctg      120

ggccctcact gaaatgctgg catttttcct gcagatgact gtggctgagg tcttgtcagt      180

gaagactcta tctttctttt ctctcttgct cttgccctgg acttgaacac agaatgtcag      240

ggagaagtag gaatgtggag tactccaggt gtcagggtac tcccagctga cctccacctg      300

cctagaattc tttaatggct tcagctgcaa gttcttgggt gggtcaggtt tgatgatgtc      360

cctgatgaag aagctgctgg tgtagttttc atacttgagc ttgtgaactg catccaccat      420

cacctcaatg ggcagactct cctcagcagc tgggcaggca ctgtcctcct ggcactccac      480

tgagtactca tactccttgt tgtcccctct gactctctct gcagagagtg tagcagctcc      540

acatgtcacc ccttgggggt cagaagagcc tctgctgctt ttgacactga atgtcaaatc      600

agtactgatt gtagtcagcc accagcaggt gaaccttcca gaataattct tggcctcaca      660

tcttagaaag gtcttatttt tgggttcttt ctggtccttt aaaatatcag tggaccaaat      720

tccatcttcc tttttgtgaa gcagcaggag ggaatggctt agaacctccc ctcctttgtg      780

acaggtgtac tggccagcat ctccaaactc tttgacttgg atggtcaggg ttttgccaga      840

gcctaagacc tcactgctct ggtccaaggt ccaggtgata ccatcttctt caggggtgtc      900

acaggtgagg accaccattt ctccaggggc atcaggatac caatccaatt ctaccacata      960

aacatctttc ttcagttccc atatggccac aaggggagat gccagaaaaa ccagggaaaa     1020

ccaagagatg accaactgct ggtgacacat ggtggcggcg cgccatttaa atctagcctt     1080

aagagctgta attgaactgg gagtggacac ctgtggagag aaaggcaaag tggatgtcag     1140

taagaccaat aggtgcctat cagaaacgca agagtcttct ctgtctcgac aagcccagtt     1200

tctattggtc tccttaaacc tgtcttgtaa ccttgatact tacctgccca gtgcctcacg     1260

accaacttca gaactgcgac ccaaatcccg gctgcgacgg aactagctgt gccacacccg     1320

gcgcgtcctt atataatcat cggcgttcac cgccccacgg agatccctcc gcagaatcgc     1380

cgagaaggga ctacttttcc tcgcctgttc cgctctctgg aaagaaaacc agtgccctag     1440

agtcacccaa gtcccgtcct aaaatgtcct tctgctgata ctggggttct aaggccgagt     1500

cttatgagca gcgggccgct gtcctgagcg tccgggcgga aggatcagga cgctcgctgc     1560

gcccttcgtc tgacgtggca gcgctcgccg tgaggagggg ggcgcccgcg ggaggcgcca     1620

aaacccggcg cggaggcctt aattaactag ttattaatag taatcaatta cggggtcatt     1680

agttcatagc ccatatatgg agttccgcgt tacataactt acggtaaatg gcccgcctgg     1740

ctgaccgccc aacgaccccc gcccattgac gtcaataatg acgtatgttc ccatagtaac     1800

gccaataggg actttccatt gacgtcaatg ggtggactat ttacggtaaa ctgcccactt     1860

ggcagtacat caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa     1920

atggcccgcc tggcattatg cccagtacat gaccttatgg gactttccta cttggcagta     1980

catctacgta ttagtcatcg ctattaccat gggtgatgcg gttttggcag tacatcaatg     2040

ggcgtggata gcggtttgac tcacggggat ttccaagtct ccaccccatt gacgtcaatg     2100

ggagtttgtt ttggcaccaa aatcaacggg actttccaaa atgtcgtaac aactccgccc     2160

cattgacgca aatgggcggt aggcgtgtac ggtgggaggt ctatataagc agagctcgtt     2220

tagtgaaccg tcagatcgcc tggagacgtc gaggaactga aaaaccagaa agttaactgg     2280

taagtttagt ctttttgtct tttatttcag gtcccggatc cggtggtggt gcaaatcaaa     2340

gaactgctcc tcagtggatg ttgcctttac ttctaggcct gtacggaagt gtttaaactt     2400

ctgctctgcg gccgcgccac catgtgtcca gctaggagcc tcctccttgt ggctaccctg     2460

gtcctcctgg accacctcag tttggccaga aacctccctg tggccactcc agacccagga     2520

atgttcccat gccttcacca ctcccaaaac ctgctgaggg cagtcagcaa catgctccag     2580

aaggccagac aaactctaga attttaccct tgcacttctg aagagattga tcatgaagat     2640

atcacaaaag ataaaaccag cacagtggag gcctgtttac cattggaatt aaccaagaat     2700

gagagttgcc taaattccag agagacctct ttcataacta atgggagttg cctggcctcc     2760

agaaagacct cttttatgat ggccctgtgc cttagtagta tttatgaaga cttgaagatg     2820

taccaggtgg agttcaagac catgaatgca aagcttctga tggatcctaa gaggcagatc     2880

tttctagatc aaaacatgct ggcagttatt gatgagctga tgcaggccct gaatttcaac     2940

agtgagactg tgccacaaaa atcctccctt gaagaacctg atttttataa aactaaaatc     3000

aagctctgca tacttcttca tgctttccgg attagggcag tgactattga tagagtgatg     3060

agctatctga atgcttcctg agcccctctc cctccccccc ccctaacgtt actggccgaa     3120

gccgcttgga ataaggccgg tgtgcgtttg tctatatgtt attttccacc atattgccgt     3180

cttttggcaa tgtgagggcc cggaaacctg gccctgtctt cttgacgagc attcctaggg     3240

gtctttcccc tctcgccaaa ggaatgcaag gtctgttgaa tgtcgtgaag gaagcagttc     3300

ctctggaagc ttcttgaaga caaacaacgt ctgtagcgac cctttgcagg cagcggaacc     3360

ccccacctgg cgacaggtgc ctctgcggcc aaaagccacg tgtataagat acacctgcaa     3420

aggcggcaca accccagtgc cacgttgtga gttggatagt tgtggaaaga gtcaaatggc     3480

tctcctcaag cgtattcaac aaggggctga aggatgccca gaaggtaccc cattgtatgg     3540

gatctgatct ggggcctcgg tacacatgct ttacatgtgt ttagtcgagg ttaaaaaaac     3600

gtctaggccc cccgaaccac ggggacgtgg ttttcctttg aaaaacacga tgataatatg     3660

gccacaatga gaattagcaa accacatttg agaagtattt ccatccagtg ctacttgtgt     3720

ttacttctaa acagtcattt tctaactgaa gctggcattc atgtcttcat tttgggctgt     3780

ttctctgcag ggcttcctaa aacagaagcc aactgggtga atgtaataag tgatttgaaa     3840

aaaattgaag atcttattca atctatgcat attgatgcta ctttatatac tgaaagtgat     3900

gttcacccca gttgcaaagt aacagcaatg aagtgctttc tcttggagtt acaagttatt     3960

tcacttgagt caggagatgc aagtattcat gatacagtag aaaatctgat catcctagca     4020

aacaacagtt tgtcttctaa tgggaatgta acagaatctg gatgcaaaga atgtgaggaa     4080

ctggaggaaa aaaatattaa agaatttttg cagagttttg tacatattgt ccaaatgttc     4140

atcaacactt cttgagcggc cgcgctagcc aattgctgtg ccttctagtt gccagccatc     4200

tgttgtttgc ccctcccccg tgccttcctt gaccctggaa ggtgccactc ccactgtcct     4260

ttcctaataa aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg     4320

gggtggggtg gggcaggaca gcaaggggga ggattgggaa gacaatagca ggcatgctgg     4380

ggatgcggtg ggctctatgg agctcgag                                        4408


<210>  27
<211>  3916
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human UbC - modified IL-12A/IL-12B/IL-15 - F2A -  (with CpG 
       modification)

<400>  27
gtcgaccaca caaaaaacca acacacagat ctaatgaaaa taaagatctt ttattggcgc       60

gcctcaagaa gtgttgatga acatttggac aatatgtaca aaactctgca aaaattcttt      120

aatatttttt tcctccagtt cctcacattc tttgcatcca gattctgtta cattcccatt      180

agaagacaaa ctgttgtttg ctaggatgat cagattttct actgtatcat gaatacttgc      240

atctcctgac tcaagtgaaa taacttgtaa ctccaagaga aagcacttca ttgctgttac      300

tttgcaactg gggtgaacat cactttcagt atataaagta gcatcaatat gcatagattg      360

aataagatct tcaatttttt tcaaatcact tattacattc acccagttgg cttctgtttt      420

aggaagccct gcagagaaac agcccaaaat gaagacatga atgccagctt cagttagaaa      480

atgactgttt agaagtaaac acaagtagca ctggatggaa atacttctca aatgtggttt      540

gctaattctc atggtggcgg cgcgccattt aaatctagcc ttaagagctg taattgaact      600

gggagtggac acctgtggag agaaaggcaa agtggatgtc agtaagacca ataggtgcct      660

atcagaaacg caagagtctt ctctgtctcg acaagcccag tttctattgg tctccttaaa      720

cctgtcttgt aaccttgata cttacctgcc cagtgcctca cgaccaactt cagaactgcg      780

acccaaatcc cggctgcgac ggaactagct gtgccacacc cggcgcgtcc ttatataatc      840

atcggcgttc accgccccac ggagatccct ccgcagaatc gccgagaagg gactactttt      900

cctcgcctgt tccgctctct ggaaagaaaa ccagtgccct agagtcaccc aagtcccgtc      960

ctaaaatgtc cttctgctga tactggggtt ctaaggccga gtcttatgag cagcgggccg     1020

ctgtcctgag cgtccgggcg gaaggatcag gacgctcgct gcgcccttcg tctgacgtgg     1080

cagcgctcgc cgtgaggagg ggggcgcccg cgggaggcgc caaaacccgg cgcggaggcc     1140

ttaattaact agttattaat agtaatcaat tacggggtca ttagttcata gcccatatat     1200

ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc     1260

ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca     1320

ttgacgtcaa tgggtggact atttacggta aactgcccac ttggcagtac atcaagtgta     1380

tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta     1440

tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg tattagtcat     1500

cgctattacc atgggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg     1560

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc     1620

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg     1680

gtaggcgtgt acggtgggag gtctatataa gcagagctcg tttagtgaac cgtcagatcg     1740

cctggagacg tcgaggaact gaaaaaccag aaagttaact ggtaagttta gtctttttgt     1800

cttttatttc aggtcccgga tccggtggtg gtgcaaatca aagaactgct cctcagtgga     1860

tgttgccttt acttctaggc ctgtacggaa gtgtttaaac ttctgctctg cggccgcgcc     1920

accatgtgtc cagctaggag cctcctcctt gtggctaccc tggtcctcct ggaccacctc     1980

agtttggcca gaaacctccc tgtggccact ccagacccag gaatgttccc atgccttcac     2040

cactcccaaa acctgctgag ggcagtcagc aacatgctcc agaaggccag acaaactcta     2100

gaattttacc cttgcacttc tgaagagatt gatcatgaag atatcacaaa agataaaacc     2160

agcacagtgg aggcctgttt accattggaa ttaaccaaga atgagagttg cctaaattcc     2220

agagagacct ctttcataac taatgggagt tgcctggcct ccagaaagac ctcttttatg     2280

atggccctgt gccttagtag tatttatgaa gacttgaaga tgtaccaggt ggagttcaag     2340

accatgaatg caaagcttct gatggatcct aagaggcaga tctttctaga tcaaaacatg     2400

ctggcagtta ttgatgagct gatgcaggcc ctgaatttca acagtgagac tgtgccacaa     2460

aaatcctccc ttgaagaacc tgatttttat aaaactaaaa tcaagctctg catacttctt     2520

catgctttcc ggattagggc agtgactatt gatagagtga tgagctatct gaatgcttcc     2580

agaaagagaa ggagtggctc aggagcccct gtgaaacaga ccctgaactt tgacctcttg     2640

aagcttgctg gggatgtgga gtctaatcct ggtccaatgt gtcaccagca gttggtcatc     2700

tcttggtttt ccctggtttt tctggcatct ccccttgtgg ccatatggga actgaagaaa     2760

gatgtttatg tggtagaatt ggattggtat cctgatgccc ctggagaaat ggtggtcctc     2820

acctgtgaca cccctgaaga agatggtatc acctggacct tggaccagag cagtgaggtc     2880

ttaggctctg gcaaaaccct gaccatccaa gtcaaagagt ttggagatgc tggccagtac     2940

acctgtcaca aaggagggga ggttctaagc cattccctcc tgctgcttca caaaaaggaa     3000

gatggaattt ggtccactga tattttaaag gaccagaaag aacccaaaaa taagaccttt     3060

ctaagatgtg aggccaagaa ttattctgga aggttcacct gctggtggct gactacaatc     3120

agtactgatt tgacattcag tgtcaaaagc agcagaggct cttctgaccc ccaaggggtg     3180

acatgtggag ctgctacact ctctgcagag agagtcagag gggacaacaa ggagtatgag     3240

tactcagtgg agtgccagga ggacagtgcc tgcccagctg ctgaggagag tctgcccatt     3300

gaggtgatgg tggatgcagt tcacaagctc aagtatgaaa actacaccag cagcttcttc     3360

atcagggaca tcatcaaacc tgacccaccc aagaacttgc agctgaagcc attaaagaat     3420

tctaggcagg tggaggtcag ctgggagtac cctgacacct ggagtactcc acattcctac     3480

ttctccctga cattctgtgt tcaagtccag ggcaagagca agagagaaaa gaaagataga     3540

gtcttcactg acaagacctc agccacagtc atctgcagga aaaatgccag catttcagtg     3600

agggcccagg acagatacta tagctcatct tggtcagaat gggcatctgt gccctgcagt     3660

tgagcggccg cgctagccaa ttgctgtgcc ttctagttgc cagccatctg ttgtttgccc     3720

ctcccccgtg ccttccttga ccctggaagg tgccactccc actgtccttt cctaataaaa     3780

tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct attctggggg gtggggtggg     3840

gcaggacagc aagggggagg attgggaaga caatagcagg catgctgggg atgcggtggg     3900

ctctatggag ctcgag                                                     3916


<210>  28
<211>  4456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human UbC- wild-type IL-12A/IL-12B/IL-15 -ODN-IRES (no CpG 
       modification)

<400>  28
gtcgactcgt cgttttgtcg ttttgtcgtt cacacaaaaa accaacacac agatctaatg       60

aaaataaaga tcttttattg gcgcgcctca actgcagggc acagatgccc attcgctcca      120

agatgagcta tagtagcggt cctgggcccg cacgctaatg ctggcatttt tgcggcagat      180

gaccgtggct gaggtcttgt ccgtgaagac tctatctttc ttttctctct tgctcttgcc      240

ctggacttga acgcagaatg tcagggagaa gtaggaatgt ggagtactcc aggtgtcagg      300

gtactcccag ctgacctcca cctgccgaga attctttaat ggcttcagct gcaagttctt      360

gggtgggtca ggtttgatga tgtccctgat gaagaagctg ctggtgtagt tttcatactt      420

gagcttgtga acggcatcca ccatcacctc aatgggcaga ctctcctcag cagctgggca      480

ggcactgtcc tcctggcact ccactgagta ctcatactcc ttgttgtccc ctctgactct      540

ctctgcagag agtgtagcag ctccgcacgt caccccttgg gggtcagaag agcctctgct      600

gcttttgaca ctgaatgtca aatcagtact gattgtcgtc agccaccagc aggtgaaacg      660

tccagaataa ttcttggcct cgcatcttag aaaggtctta tttttgggtt ctttctggtc      720

ctttaaaata tcagtggacc aaattccatc ttcctttttg tgaagcagca ggagcgaatg      780

gcttagaacc tcgcctcctt tgtgacaggt gtactggcca gcatctccaa actctttgac      840

ttggatggtc agggttttgc cagagcctaa gacctcactg ctctggtcca aggtccaggt      900

gataccatct tcttcagggg tgtcacaggt gaggaccacc atttctccag gggcatccgg      960

ataccaatcc aattctacga cataaacatc tttcttcagt tcccatatgg ccacgagggg     1020

agatgccaga aaaaccaggg aaaaccaaga gatgaccaac tgctggtgac acatggtggc     1080

ggcgcgccat ttaaatctag ccttaagagc tgtaattgaa ctgggagtgg acacctgtgg     1140

agagaaaggc aaagtggatg tcagtaagac caataggtgc ctatcagaaa cgcaagagtc     1200

ttctctgtct cgacaagccc agtttctatt ggtctcctta aacctgtctt gtaaccttga     1260

tacttacctg cccagtgcct cacgaccaac ttcagaactg cgacccaaat cccggctgcg     1320

acggaactag ctgtgccaca cccggcgcgt ccttatataa tcatcggcgt tcaccgcccc     1380

acggagatcc ctccgcagaa tcgccgagaa gggactactt ttcctcgcct gttccgctct     1440

ctggaaagaa aaccagtgcc ctagagtcac ccaagtcccg tcctaaaatg tccttctgct     1500

gatactgggg ttctaaggcc gagtcttatg agcagcgggc cgctgtcctg agcgtccggg     1560

cggaaggatc aggacgctcg ctgcgccctt cgtctgacgt ggcagcgctc gccgtgagga     1620

ggggggcgcc cgcgggaggc gccaaaaccc ggcgcggagg ccttaattaa ctagttatta     1680

atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata     1740

acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat     1800

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga     1860

ctatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc     1920

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt     1980

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatgggtga     2040

tgcggttttg gcagtacatc aatgggcgtg gatagcggtt tgactcacgg ggatttccaa     2100

gtctccaccc cattgacgtc aatgggagtt tgttttggca ccaaaatcaa cgggactttc     2160

caaaatgtcg taacaactcc gccccattga cgcaaatggg cggtaggcgt gtacggtggg     2220

aggtctatat aagcagagct cgtttagtga accgtcagat cgcctggaga cgtcgaggaa     2280

ctgaaaaacc agaaagttaa ctggtaagtt tagtcttttt gtcttttatt tcaggtcccg     2340

gatccggtgg tggtgcaaat caaagaactg ctcctcagtg gatgttgcct ttacttctag     2400

gcctgtacgg aagtgtttaa acttctgctc tgcggccgcg ccaccatgtg tccagcgcgc     2460

agcctcctcc ttgtggctac cctggtcctc ctggaccacc tcagtttggc cagaaacctc     2520

cccgtggcca ctccagaccc aggaatgttc ccatgccttc accactccca aaacctgctg     2580

agggccgtca gcaacatgct ccagaaggcc agacaaactc tagaatttta cccttgcact     2640

tctgaagaga ttgatcatga agatatcaca aaagataaaa ccagcacagt ggaggcctgt     2700

ttaccattgg aattaaccaa gaatgagagt tgcctaaatt ccagagagac ctctttcata     2760

actaatggga gttgcctggc ctccagaaag acctctttta tgatggccct gtgccttagt     2820

agtatttatg aagacttgaa gatgtaccag gtggagttca agaccatgaa tgcaaagctt     2880

ctgatggatc ctaagaggca gatctttcta gatcaaaaca tgctggcagt tattgatgag     2940

ctgatgcagg ccctgaattt caacagtgag actgtgccac aaaaatcctc ccttgaagaa     3000

ccggattttt ataaaactaa aatcaagctc tgcatacttc ttcatgcttt ccggattcgg     3060

gcagtgacta ttgatagagt gatgagctat ctgaatgctt cctgagcccc tctccctccc     3120

ccccccctaa cgttactggc cgaagccgct tggaataagg ccggtgtgcg tttgtctata     3180

tgttattttc caccatattg ccgtcttttg gcaatgtgag ggcccggaaa cctggccctg     3240

tcttcttgac gagcattcct aggggtcttt cccctctcgc caaaggaatg caaggtctgt     3300

tgaatgtcgt gaaggaagca gttcctctgg aagcttcttg aagacaaaca acgtctgtag     3360

cgaccctttg caggcagcgg aaccccccac ctggcgacag gtgcctctgc ggccaaaagc     3420

cacgtgtata agatacacct gcaaaggcgg cacaacccca gtgccacgtt gtgagttgga     3480

tagttgtgga aagagtcaaa tggctctcct caagcgtatt caacaagggg ctgaaggatg     3540

cccagaaggt accccattgt atgggatctg atctggggcc tcggtacaca tgctttacat     3600

gtgtttagtc gaggttaaaa aaacgtctag gccccccgaa ccacggggac gtggttttcc     3660

tttgaaaaac acgatgataa tatggccaca atgagaattt cgaaaccaca tttgagaagt     3720

atttccatcc agtgctactt gtgtttactt ctaaacagtc attttctaac tgaagctggc     3780

attcatgtct tcattttggg ctgtttctct gcagggcttc ctaaaacaga agccaactgg     3840

gtgaatgtaa taagtgattt gaaaaaaatt gaagatctta ttcaatctat gcatattgat     3900

gctactttat atacggaaag tgatgttcac cccagttgca aagtaacagc aatgaagtgc     3960

tttctcttgg agttacaagt tatttcactt gagtccggag atgcaagtat tcatgataca     4020

gtagaaaatc tgatcatcct agcaaacaac agtttgtctt ctaatgggaa tgtaacagaa     4080

tctggatgca aagaatgtga ggaactggag gaaaaaaata ttaaagaatt tttgcagagt     4140

tttgtacata ttgtccaaat gttcatcaac acttcttgag cggccgcgct agccaattgc     4200

tgtgccttct agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct     4260

ggaaggtgcc actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct     4320

gagtaggtgt cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg     4380

ggaagacaat agcaggcatg ctggggatgc ggtgggctct atgtcgtcgt tttgtcgttt     4440

tgtcgttgag ctcgag                                                     4456


<210>  29
<211>  3964
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human UbC- wild-type IL-12A/IL-12B/IL-15 -ODN-F2A (no CpG 
       modification)

<400>  29
gtcgactcgt cgttttgtcg ttttgtcgtt cacacaaaaa accaacacac agatctaatg       60

aaaataaaga tcttttattg gcgcgcctca agaagtgttg atgaacattt ggacaatatg      120

tacaaaactc tgcaaaaatt ctttaatatt tttttcctcc agttcctcac attctttgca      180

tccagattct gttacattcc cattagaaga caaactgttg tttgctagga tgatcagatt      240

ttctactgta tcatgaatac ttgcatctcc ggactcaagt gaaataactt gtaactccaa      300

gagaaagcac ttcattgctg ttactttgca actggggtga acatcacttt ccgtatataa      360

agtagcatca atatgcatag attgaataag atcttcaatt tttttcaaat cacttattac      420

attcacccag ttggcttctg ttttaggaag ccctgcagag aaacagccca aaatgaagac      480

atgaatgcca gcttcagtta gaaaatgact gtttagaagt aaacacaagt agcactggat      540

ggaaatactt ctcaaatgtg gtttcgaaat tctcatggtg gcggcgcgcc atttaaatct      600

agccttaaga gctgtaattg aactgggagt ggacacctgt ggagagaaag gcaaagtgga      660

tgtcagtaag accaataggt gcctatcaga aacgcaagag tcttctctgt ctcgacaagc      720

ccagtttcta ttggtctcct taaacctgtc ttgtaacctt gatacttacc tgcccagtgc      780

ctcacgacca acttcagaac tgcgacccaa atcccggctg cgacggaact agctgtgcca      840

cacccggcgc gtccttatat aatcatcggc gttcaccgcc ccacggagat ccctccgcag      900

aatcgccgag aagggactac ttttcctcgc ctgttccgct ctctggaaag aaaaccagtg      960

ccctagagtc acccaagtcc cgtcctaaaa tgtccttctg ctgatactgg ggttctaagg     1020

ccgagtctta tgagcagcgg gccgctgtcc tgagcgtccg ggcggaagga tcaggacgct     1080

cgctgcgccc ttcgtctgac gtggcagcgc tcgccgtgag gaggggggcg cccgcgggag     1140

gcgccaaaac ccggcgcgga ggccttaatt aactagttat taatagtaat caattacggg     1200

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc     1260

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat     1320

agtaacgcca atagggactt tccattgacg tcaatgggtg gactatttac ggtaaactgc     1380

ccacttggca gtacatcaag tgtatcatat gccaagtacg ccccctattg acgtcaatga     1440

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttatgggact ttcctacttg     1500

gcagtacatc tacgtattag tcatcgctat taccatgggt gatgcggttt tggcagtaca     1560

tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac cccattgacg     1620

tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt cgtaacaact     1680

ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag     1740

ctcgtttagt gaaccgtcag atcgcctgga gacgtcgagg aactgaaaaa ccagaaagtt     1800

aactggtaag tttagtcttt ttgtctttta tttcaggtcc cggatccggt ggtggtgcaa     1860

atcaaagaac tgctcctcag tggatgttgc ctttacttct aggcctgtac ggaagtgttt     1920

aaacttctgc tctgcggccg cgccaccatg tgtccagcgc gcagcctcct ccttgtggct     1980

accctggtcc tcctggacca cctcagtttg gccagaaacc tccccgtggc cactccagac     2040

ccaggaatgt tcccatgcct tcaccactcc caaaacctgc tgagggccgt cagcaacatg     2100

ctccagaagg ccagacaaac tctagaattt tacccttgca cttctgaaga gattgatcat     2160

gaagatatca caaaagataa aaccagcaca gtggaggcct gtttaccatt ggaattaacc     2220

aagaatgaga gttgcctaaa ttccagagag acctctttca taactaatgg gagttgcctg     2280

gcctccagaa agacctcttt tatgatggcc ctgtgcctta gtagtattta tgaagacttg     2340

aagatgtacc aggtggagtt caagaccatg aatgcaaagc ttctgatgga tcctaagagg     2400

cagatctttc tagatcaaaa catgctggca gttattgatg agctgatgca ggccctgaat     2460

ttcaacagtg agactgtgcc acaaaaatcc tcccttgaag aaccggattt ttataaaact     2520

aaaatcaagc tctgcatact tcttcatgct ttccggattc gggcagtgac tattgataga     2580

gtgatgagct atctgaatgc ttccagaaag agaaggagtg gctcaggagc ccctgtgaaa     2640

cagaccctga actttgacct cttgaagctt gctggggatg tggagtctaa tcctggtcca     2700

atgtgtcacc agcagttggt catctcttgg ttttccctgg tttttctggc atctcccctc     2760

gtggccatat gggaactgaa gaaagatgtt tatgtcgtag aattggattg gtatccggat     2820

gcccctggag aaatggtggt cctcacctgt gacacccctg aagaagatgg tatcacctgg     2880

accttggacc agagcagtga ggtcttaggc tctggcaaaa ccctgaccat ccaagtcaaa     2940

gagtttggag atgctggcca gtacacctgt cacaaaggag gcgaggttct aagccattcg     3000

ctcctgctgc ttcacaaaaa ggaagatgga atttggtcca ctgatatttt aaaggaccag     3060

aaagaaccca aaaataagac ctttctaaga tgcgaggcca agaattattc tggacgtttc     3120

acctgctggt ggctgacgac aatcagtact gatttgacat tcagtgtcaa aagcagcaga     3180

ggctcttctg acccccaagg ggtgacgtgc ggagctgcta cactctctgc agagagagtc     3240

agaggggaca acaaggagta tgagtactca gtggagtgcc aggaggacag tgcctgccca     3300

gctgctgagg agagtctgcc cattgaggtg atggtggatg ccgttcacaa gctcaagtat     3360

gaaaactaca ccagcagctt cttcatcagg gacatcatca aacctgaccc acccaagaac     3420

ttgcagctga agccattaaa gaattctcgg caggtggagg tcagctggga gtaccctgac     3480

acctggagta ctccacattc ctacttctcc ctgacattct gcgttcaagt ccagggcaag     3540

agcaagagag aaaagaaaga tagagtcttc acggacaaga cctcagccac ggtcatctgc     3600

cgcaaaaatg ccagcattag cgtgcgggcc caggaccgct actatagctc atcttggagc     3660

gaatgggcat ctgtgccctg cagttgagcg gccgcgctag ccaattgctg tgccttctag     3720

ttgccagcca tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac     3780

tcccactgtc ctttcctaat aaaatgagga aattgcatcg cattgtctga gtaggtgtca     3840

ttctattctg gggggtgggg tggggcagga cagcaagggg gaggattggg aagacaatag     3900

caggcatgct ggggatgcgg tgggctctat gtcgtcgttt tgtcgttttg tcgttgagct     3960

cgag                                                                  3964


<210>  30
<211>  2782
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human CMV- wild-type IL-12A/IL-12B - -F2A (no CpG modification)

<400>  30
gtcgacttaa ttaactagtt attaatagta atcaattacg gggtcattag ttcatagccc       60

atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa      120

cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac      180

tttccattga cgtcaatggg tggactattt acggtaaact gcccacttgg cagtacatca      240

agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg      300

gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt      360

agtcatcgct attaccatgg gtgatgcggt tttggcagta catcaatggg cgtggatagc      420

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt      480

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa      540

tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccgtc      600

agatcgcctg gagacgtcga ggaactgaaa aaccagaaag ttaactggta agtttagtct      660

ttttgtcttt tatttcaggt cccggatccg gtggtggtgc aaatcaaaga actgctcctc      720

agtggatgtt gcctttactt ctaggcctgt acggaagtgt ttaaacttct gctctgcggc      780

cgcgccacca tgtgtccagc gcgcagcctc ctccttgtgg ctaccctggt cctcctggac      840

cacctcagtt tggccagaaa cctccccgtg gccactccag acccaggaat gttcccatgc      900

cttcaccact cccaaaacct gctgagggcc gtcagcaaca tgctccagaa ggccagacaa      960

actctagaat tttacccttg cacttctgaa gagattgatc atgaagatat cacaaaagat     1020

aaaaccagca cagtggaggc ctgtttacca ttggaattaa ccaagaatga gagttgccta     1080

aattccagag agacctcttt cataactaat gggagttgcc tggcctccag aaagacctct     1140

tttatgatgg ccctgtgcct tagtagtatt tatgaagact tgaagatgta ccaggtggag     1200

ttcaagacca tgaatgcaaa gcttctgatg gatcctaaga ggcagatctt tctagatcaa     1260

aacatgctgg cagttattga tgagctgatg caggccctga atttcaacag tgagactgtg     1320

ccacaaaaat cctcccttga agaaccggat ttttataaaa ctaaaatcaa gctctgcata     1380

cttcttcatg ctttccggat tcgggcagtg actattgata gagtgatgag ctatctgaat     1440

gcttccagaa agagaaggag tggctcagga gcccctgtga aacagaccct gaactttgac     1500

ctcttgaagc ttgctgggga tgtggagtct aatcctggtc caatgtgtca ccagcagttg     1560

gtcatctctt ggttttccct ggtttttctg gcatctcccc tcgtggccat atgggaactg     1620

aagaaagatg tttatgtcgt agaattggat tggtatccgg atgcccctgg agaaatggtg     1680

gtcctcacct gtgacacccc tgaagaagat ggtatcacct ggaccttgga ccagagcagt     1740

gaggtcttag gctctggcaa aaccctgacc atccaagtca aagagtttgg agatgctggc     1800

cagtacacct gtcacaaagg aggcgaggtt ctaagccatt cgctcctgct gcttcacaaa     1860

aaggaagatg gaatttggtc cactgatatt ttaaaggacc agaaagaacc caaaaataag     1920

acctttctaa gatgcgaggc caagaattat tctggacgtt tcacctgctg gtggctgacg     1980

acaatcagta ctgatttgac attcagtgtc aaaagcagca gaggctcttc tgacccccaa     2040

ggggtgacgt gcggagctgc tacactctct gcagagagag tcagagggga caacaaggag     2100

tatgagtact cagtggagtg ccaggaggac agtgcctgcc cagctgctga ggagagtctg     2160

cccattgagg tgatggtgga tgccgttcac aagctcaagt atgaaaacta caccagcagc     2220

ttcttcatca gggacatcat caaacctgac ccacccaaga acttgcagct gaagccatta     2280

aagaattctc ggcaggtgga ggtcagctgg gagtaccctg acacctggag tactccacat     2340

tcctacttct ccctgacatt ctgcgttcaa gtccagggca agagcaagag agaaaagaaa     2400

gatagagtct tcacggacaa gacctcagcc acggtcatct gccgcaaaaa tgccagcatt     2460

agcgtgcggg cccaggaccg ctactatagc tcatcttgga gcgaatgggc atctgtgccc     2520

tgcagttgag cggccgcgct agccaattgc tgtgccttct agttgccagc catctgttgt     2580

ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta     2640

ataaaatgag gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg     2700

ggtggggcag gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc     2760

ggtgggctct atggagctcg ag                                              2782


<210>  31
<211>  1531
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human CMV- wild-type IL-15 (no CpG modification)

<400>  31
gtcgacttaa ttaactagtt attaatagta atcaattacg gggtcattag ttcatagccc       60

atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa      120

cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac      180

tttccattga cgtcaatggg tggactattt acggtaaact gcccacttgg cagtacatca      240

agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg      300

gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt      360

agtcatcgct attaccatgg gtgatgcggt tttggcagta catcaatggg cgtggatagc      420

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt      480

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa      540

tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccgtc      600

agatcgcctg gagacgtcga ggaactgaaa aaccagaaag ttaactggta agtttagtct      660

ttttgtcttt tatttcaggt cccggatccg gtggtggtgc aaatcaaaga actgctcctc      720

agtggatgtt gcctttactt ctaggcctgt acggaagtgt ttaaacttct gctctgcggc      780

cgcgccacca tgagaatttc gaaaccacat ttgagaagta tttccatcca gtgctacttg      840

tgtttacttc taaacagtca ttttctaact gaagctggca ttcatgtctt cattttgggc      900

tgtttctctg cagggcttcc taaaacagaa gccaactggg tgaatgtaat aagtgatttg      960

aaaaaaattg aagatcttat tcaatctatg catattgatg ctactttata tacggaaagt     1020

gatgttcacc ccagttgcaa agtaacagca atgaagtgct ttctcttgga gttacaagtt     1080

atttcacttg agtccggaga tgcaagtatt catgatacag tagaaaatct gatcatccta     1140

gcaaacaaca gtttgtcttc taatgggaat gtaacagaat ctggatgcaa agaatgtgag     1200

gaactggagg aaaaaaatat taaagaattt ttgcagagtt ttgtacatat tgtccaaatg     1260

ttcatcaaca cttcttgagc ggccgcgcta gccaattgct gtgccttcta gttgccagcc     1320

atctgttgtt tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt     1380

cctttcctaa taaaatgagg aaattgcatc gcattgtctg agtaggtgtc attctattct     1440

ggggggtggg gtggggcagg acagcaaggg ggaggattgg gaagacaata gcaggcatgc     1500

tggggatgcg gtgggctcta tggagctcga g                                    1531


<210>  32
<211>  5
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Class I AU rich elements

<400>  32
auuua                                                                    5


<210>  33
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Class II AU rich elements


<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  Wherein N can be either U or A

<400>  33
uuauuuann                                                                9


<210>  34
<211>  4509
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human CAG - wild-type IL-12A/IL-12B - IRES (no CpG modification) 
       construct

<400>  34
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tagtattaaa cgcgtgtcga cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggg tcgaggtgag      540

ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa ttttgtattt      600

atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg cgcgcgccag      660

gcggggcggg gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca      720

atcagagcgg cgcgctccga aagtttcctt ttatggcgag gcggcggcgg cggcggccct      780

ataaaaagcg aagcgcgcgg cgggcgggag tcgctgcgcg ctgccttcgc cccgtgcccc      840

gctccgccgc cgcctcgcgc cgcccgcccc ggctctgact gaccgcgtta ctcccacagg      900

tgagcgggcg ggacggccct tctcctccgg gctgtaatta gcgcttggtt taatgacggc      960

tcgtttcttt tctgtggctg cgtgaaagcc ttgaggggct ccgggagggc cctttgtgcg     1020

gggggagcgg ctcggggggt gcgtgcgtgt gtgtgtgcgt ggggagcgcc gcgtgcggct     1080

ccgcgctgcc cggcggctgt gagcgctgcg ggcgcggcgc ggggctttgt gcgctccgca     1140

gtgtgcgcga gaggagcgcg gccgggggcg gtgccacgcg gtgcgggggg ggctgcgagg     1200

ggaacaaagg ctgcgtgcgg ggtgtgtgcg tggggggggt gagcaggggg tgtgggcgcg     1260

gcggtcgggc tgtaaccccc ccctgcaccc ccctccccga gttgctgagc acggcccggc     1320

ttcgggtgcg gggctccgtg cggggcgtgg cgcggggctc gccgtgccgg gcggggggtg     1380

gcggcgggtg ggggtgccgg gcggggcggg gccgcctcgg gccggggagg gctcggggga     1440

ggggcgcggc ggcccccgga gcgccggcgg ctgtcgaggc gcggcgagcc gcagccattg     1500

ccttttatgg taatcgtgcg agagggcgca gggacttcct ttgtcccaaa tctgtgcgga     1560

gccgaaatct gggaggcgcc gccgcacccc ctctagcggg cgcggggcga agcggtgcgg     1620

cgccggcagg aaggaaatgg gcggggaggg ccttcgtgcg tcgccgcgcc gccgtcccct     1680

tctccctctc cagcctcggg gctgtccgcg gggggacggc tgccttcggg ggggacgggg     1740

cagggcgggg ttcggcttct ggcgtgtgac cggcggtcta gactctgcta accttgttca     1800

tgccttcttc tctttcctac agctcctggg caacgtgctg gttgttgtgc tgtctcatca     1860

ttttggcaaa gaattcaagc ttccagctag cgccaccatg tgtccagcgc gcagcctcct     1920

ccttgtggct accctggtcc tcctggacca cctcagtttg gccagaaacc tccccgtggc     1980

cactccagac ccaggaatgt tcccatgcct tcaccactcc caaaacctgc tgagggccgt     2040

cagcaacatg ctccagaagg ccagacaaac tctagaattt tacccttgca cttctgaaga     2100

gattgatcat gaagatatca caaaagataa aaccagcaca gtggaggcct gtttaccatt     2160

ggaattaacc aagaatgaga gttgcctaaa ttccagagag acctctttca taactaatgg     2220

gagttgcctg gcctccagaa agacctcttt tatgatggcc ctgtgcctta gtagtattta     2280

tgaagacttg aagatgtacc aggtggagtt caagaccatg aatgcaaagc ttctgatgga     2340

tcctaagagg cagatctttc tagatcaaaa catgctggca gttattgatg agctgatgca     2400

ggccctgaat ttcaacagtg agactgtgcc acaaaaatcc tcccttgaag aaccggattt     2460

ttataaaact aaaatcaagc tctgcatact tcttcatgct ttccggattc gggcagtgac     2520

tattgataga gtgatgagct atctgaatgc ttcctgagcc cctctccctc ccccccccct     2580

aacgttactg gccgaagccg cttggaataa ggccggtgtg cgtttgtcta tatgttattt     2640

tccaccatat tgccgtcttt tggcaatgtg agggcccgga aacctggccc tgtcttcttg     2700

acgagcattc ctaggggtct ttcccctctc gccaaaggaa tgcaaggtct gttgaatgtc     2760

gtgaaggaag cagttcctct ggaagcttct tgaagacaaa caacgtctgt agcgaccctt     2820

tgcaggcagc ggaacccccc acctggcgac aggtgcctct gcggccaaaa gccacgtgta     2880

taagatacac ctgcaaaggc ggcacaaccc cagtgccacg ttgtgagttg gatagttgtg     2940

gaaagagtca aatggctctc ctcaagcgta ttcaacaagg ggctgaagga tgcccagaag     3000

gtaccccatt gtatgggatc tgatctgggg cctcggtaca catgctttac atgtgtttag     3060

tcgaggttaa aaaaacgtct aggccccccg aaccacgggg acgtggtttt cctttgaaaa     3120

acacgatgat aatatggcca caatgtgtca ccagcagttg gtcatctctt ggttttccct     3180

ggtttttctg gcatctcccc tcgtggccat atgggaactg aagaaagatg tttatgtcgt     3240

agaattggat tggtatccgg atgcccctgg agaaatggtg gtcctcacct gtgacacccc     3300

tgaagaagat ggtatcacct ggaccttgga ccagagcagt gaggtcttag gctctggcaa     3360

aaccctgacc atccaagtca aagagtttgg agatgctggc cagtacacct gtcacaaagg     3420

aggcgaggtt ctaagccatt cgctcctgct gcttcacaaa aaggaagatg gaatttggtc     3480

cactgatatt ttaaaggacc agaaagaacc caaaaataag acctttctaa gatgcgaggc     3540

caagaattat tctggacgtt tcacctgctg gtggctgacg acaatcagta ctgatttgac     3600

attcagtgtc aaaagcagca gaggctcttc tgacccccaa ggggtgacgt gcggagctgc     3660

tacactctct gcagagagag tcagagggga caacaaggag tatgagtact cagtggagtg     3720

ccaggaggac agtgcctgcc cagctgctga ggagagtctg cccattgagg tgatggtgga     3780

tgccgttcac aagctcaagt atgaaaacta caccagcagc ttcttcatca gggacatcat     3840

caaacctgac ccacccaaga acttgcagct gaagccatta aagaattctc ggcaggtgga     3900

ggtcagctgg gagtaccctg acacctggag tactccacat tcctacttct ccctgacatt     3960

ctgcgttcaa gtccagggca agagcaagag agaaaagaaa gatagagtct tcacggacaa     4020

gacctcagcc acggtcatct gccgcaaaaa tgccagcatt agcgtgcggg cccaggaccg     4080

ctactatagc tcatcttgga gcgaatgggc atctgtgccc tgcagttgac aattgctgtg     4140

ccttctagtt gccagccatc tgttgtttgc ccctcccccg tgccttcctt gaccctggaa     4200

ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca ttgtctgagt     4260

aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga ggattgggaa     4320

gacaatagca ggcatgctgg ggatgcggtg ggctctatgg agctcgagag gaacccctag     4380

tgatggagtt ggccactccc tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa     4440

aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga gcgcgcagct     4500

gcagatctg                                                             4509


<210>  35
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human CAG - wild-type IL-12A/IL-12B - IRES (no CpG modification) 
       expression sequence

<400>  35
gctagcgcca ccatgtgtcc agcgcgcagc ctcctccttg tggctaccct ggtcctcctg       60

gaccacctca gtttggccag aaacctcccc gtggccactc cagacccagg aatgttccca      120

tgccttcacc actcccaaaa cctgctgagg gccgtcagca acatgctcca gaaggccaga      180

caaactctag aattttaccc ttgcacttct gaagagattg atcatgaaga tatcacaaaa      240

gataaaacca gcacagtgga ggcctgttta ccattggaat taaccaagaa tgagagttgc      300

ctaaattcca gagagacctc tttcataact aatgggagtt gcctggcctc cagaaagacc      360

tcttttatga tggccctgtg ccttagtagt atttatgaag acttgaagat gtaccaggtg      420

gagttcaaga ccatgaatgc aaagcttctg atggatccta agaggcagat ctttctagat      480

caaaacatgc tggcagttat tgatgagctg atgcaggccc tgaatttcaa cagtgagact      540

gtgccacaaa aatcctccct tgaagaaccg gatttttata aaactaaaat caagctctgc      600

atacttcttc atgctttccg gattcgggca gtgactattg atagagtgat gagctatctg      660

aatgcttcct gagcccctct ccctcccccc cccctaacgt tactggccga agccgcttgg      720

aataaggccg gtgtgcgttt gtctatatgt tattttccac catattgccg tcttttggca      780

atgtgagggc ccggaaacct ggccctgtct tcttgacgag cattcctagg ggtctttccc      840

ctctcgccaa aggaatgcaa ggtctgttga atgtcgtgaa ggaagcagtt cctctggaag      900

cttcttgaag acaaacaacg tctgtagcga ccctttgcag gcagcggaac cccccacctg      960

gcgacaggtg cctctgcggc caaaagccac gtgtataaga tacacctgca aaggcggcac     1020

aaccccagtg ccacgttgtg agttggatag ttgtggaaag agtcaaatgg ctctcctcaa     1080

gcgtattcaa caaggggctg aaggatgccc agaaggtacc ccattgtatg ggatctgatc     1140

tggggcctcg gtacacatgc tttacatgtg tttagtcgag gttaaaaaaa cgtctaggcc     1200

ccccgaacca cggggacgtg gttttccttt gaaaaacacg atgataatat ggccacaatg     1260

tgtcaccagc agttggtcat ctcttggttt tccctggttt ttctggcatc tcccctcgtg     1320

gccatatggg aactgaagaa agatgtttat gtcgtagaat tggattggta tccggatgcc     1380

cctggagaaa tggtggtcct cacctgtgac acccctgaag aagatggtat cacctggacc     1440

ttggaccaga gcagtgaggt cttaggctct ggcaaaaccc tgaccatcca agtcaaagag     1500

tttggagatg ctggccagta cacctgtcac aaaggaggcg aggttctaag ccattcgctc     1560

ctgctgcttc acaaaaagga agatggaatt tggtccactg atattttaaa ggaccagaaa     1620

gaacccaaaa ataagacctt tctaagatgc gaggccaaga attattctgg acgtttcacc     1680

tgctggtggc tgacgacaat cagtactgat ttgacattca gtgtcaaaag cagcagaggc     1740

tcttctgacc cccaaggggt gacgtgcgga gctgctacac tctctgcaga gagagtcaga     1800

ggggacaaca aggagtatga gtactcagtg gagtgccagg aggacagtgc ctgcccagct     1860

gctgaggaga gtctgcccat tgaggtgatg gtggatgccg ttcacaagct caagtatgaa     1920

aactacacca gcagcttctt catcagggac atcatcaaac ctgacccacc caagaacttg     1980

cagctgaagc cattaaagaa ttctcggcag gtggaggtca gctgggagta ccctgacacc     2040

tggagtactc cacattccta cttctccctg acattctgcg ttcaagtcca gggcaagagc     2100

aagagagaaa agaaagatag agtcttcacg gacaagacct cagccacggt catctgccgc     2160

aaaaatgcca gcattagcgt gcgggcccag gaccgctact atagctcatc ttggagcgaa     2220

tgggcatctg tgccctgcag ttgacaattg                                      2250


<210>  36
<211>  2766
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human CAG - wild-type IL-15 (no CpG modification) construct

<400>  36
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tagtattaaa cgcgtgtcga cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggg tcgaggtgag      540

ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa ttttgtattt      600

atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg cgcgcgccag      660

gcggggcggg gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca      720

atcagagcgg cgcgctccga aagtttcctt ttatggcgag gcggcggcgg cggcggccct      780

ataaaaagcg aagcgcgcgg cgggcgggag tcgctgcgcg ctgccttcgc cccgtgcccc      840

gctccgccgc cgcctcgcgc cgcccgcccc ggctctgact gaccgcgtta ctcccacagg      900

tgagcgggcg ggacggccct tctcctccgg gctgtaatta gcgcttggtt taatgacggc      960

tcgtttcttt tctgtggctg cgtgaaagcc ttgaggggct ccgggagggc cctttgtgcg     1020

gggggagcgg ctcggggggt gcgtgcgtgt gtgtgtgcgt ggggagcgcc gcgtgcggct     1080

ccgcgctgcc cggcggctgt gagcgctgcg ggcgcggcgc ggggctttgt gcgctccgca     1140

gtgtgcgcga gaggagcgcg gccgggggcg gtgccacgcg gtgcgggggg ggctgcgagg     1200

ggaacaaagg ctgcgtgcgg ggtgtgtgcg tggggggggt gagcaggggg tgtgggcgcg     1260

gcggtcgggc tgtaaccccc ccctgcaccc ccctccccga gttgctgagc acggcccggc     1320

ttcgggtgcg gggctccgtg cggggcgtgg cgcggggctc gccgtgccgg gcggggggtg     1380

gcggcgggtg ggggtgccgg gcggggcggg gccgcctcgg gccggggagg gctcggggga     1440

ggggcgcggc ggcccccgga gcgccggcgg ctgtcgaggc gcggcgagcc gcagccattg     1500

ccttttatgg taatcgtgcg agagggcgca gggacttcct ttgtcccaaa tctgtgcgga     1560

gccgaaatct gggaggcgcc gccgcacccc ctctagcggg cgcggggcga agcggtgcgg     1620

cgccggcagg aaggaaatgg gcggggaggg ccttcgtgcg tcgccgcgcc gccgtcccct     1680

tctccctctc cagcctcggg gctgtccgcg gggggacggc tgccttcggg ggggacgggg     1740

cagggcgggg ttcggcttct ggcgtgtgac cggcggtcta gactctgcta accatgttca     1800

tgccttcttc tctttcctac agctcctggg caacgtgctg gttgttgtgc tgtctcatca     1860

ttttggcaaa gaattcaagc ttccagctag cgccaccatg agaatttcga aaccacattt     1920

gagaagtatt tccatccagt gctacttgtg tttacttcta aacagtcatt ttctaactga     1980

agctggcatt catgtcttca ttttgggctg tttctctgct gggcttccta aaacagaagc     2040

caactgggtg aatgtaataa gtgatttgaa aaaaattgaa gatcttattc aatctatgca     2100

tattgatgct actttatata cggaaagtga tgttcacccc agttgcaaag taacagcaat     2160

gaagtgcttt ctcttggagt tacaagttat ttcacttgag tccggagatg caagtattca     2220

tgatacagta gaaaatctga tcatcctagc aaacaacagt ttgtcttcta atgggaatgt     2280

aacagaatct ggatgcaaag aatgtgagga actggaggaa aaaaatatta aagaattttt     2340

gcagagtttt gtacatattg tccaaatgtt catcaacact tcttgacaat tgctgtgcct     2400

tctagttgcc agccatctgt tgtttgcccc tcccccgtgc cttccttgac cctggaaggt     2460

gccactccca ctgtcctttc ctaataaaat gaggaaattg catcgcattg tctgagtagg     2520

tgtcattcta ttctgggggg tggggtgggg caggacagca agggggagga ttgggaagac     2580

aatagcaggc atgctgggga tgcggtgggc tctatggagc tcgagaggaa cccctagtga     2640

tggagttggc cactccctct ctgcgcgctc gctcgctcac tgaggccggg cgaccaaagg     2700

tcgcccgacg cccgggcttt gcccgggcgg cctcagtgag cgagcgagcg cgcagctgca     2760

gatctg                                                                2766


<210>  37
<211>  508
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human CAG - wild-type IL-15 (no CpG modification) expression 
       sequence

<400>  37
agctagcgcc accatgagaa tttcgaaacc acatttgaga agtatttcca tccagtgcta       60

cttgtgttta cttctaaaca gtcattttct aactgaagct ggcattcatg tcttcatttt      120

gggctgtttc tctgctgggc ttcctaaaac agaagccaac tgggtgaatg taataagtga      180

tttgaaaaaa attgaagatc ttattcaatc tatgcatatt gatgctactt tatatacgga      240

aagtgatgtt caccccagtt gcaaagtaac agcaatgaag tgctttctct tggagttaca      300

agttatttca cttgagtccg gagatgcaag tattcatgat acagtagaaa atctgatcat      360

cctagcaaac aacagtttgt cttctaatgg gaatgtaaca gaatctggat gcaaagaatg      420

tgaggaactg gaggaaaaaa atattaaaga atttttgcag agttttgtac atattgtcca      480

aatgttcatc aacacttctt gacaattg                                         508


<210>  38
<211>  4912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse EF1a - wild-type IL-15 (no CpG modification) and modified 
       IL-12B (with CpG modification) construct

<400>  38
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tagtattaaa cgcgtgtcga ccacacaaaa aaccaacaca cagatctaat      180

gaaaataaag atcttttatt ggcgcgcctc aggatcggac tctgcaggga acacaggccc      240

acttgctgca ggaggaattg taatagcgat cctgagcttg cacgcagaca ttcccgcctt      300

tgcactggac ttcggtagat gtcttctcta cgaggaacgc tcctttctgg ttacacccct      360

cctctgtctc cttcatcttt tctttcttgc gctggattcg aacaaagaac ttgagggaga      420

agtaggaatg gggagtgctc caggagtcag ggtactccca gctgacctcc acctgtgagt      480

tcttcaaagg cttcatctgc aagttcttgg gcgggtctgg tttgatgatg tccctgatga      540

agaagctggt gctgtagttc tcatatttat tctgctgccg tgcttccaac gccagttcaa      600

tgggcagggt ctcctcggca gttgggcagg tgacatcctc ctggcaggac actgaatact      660

tctcatagtc cctttggtcc agtgtgacct tctctgcaga cagagacgcc attccacatg      720

tcactgcccg agagtcaggg gaactgctac tgctcttgat gttgaacttc aagtccatgt      780

ttctttgcac cagccatgag cacgtgaacc gtccggagta atttggtgct tcacacttca      840

ggaaagtctt gtttttgaaa ttttttaaaa tttcagtgga ccaaattcca ttttccttct      900

tgtggagcag cagatgtgag tggctcagag tctcgcctcc tttgtggcag gtgtactggc      960

cagcatctag aaactctttg acagtgatgg tcagggtctt tccagagcct atgactccat     1020

gtctctggtc tgaggtccag gtgatgtcat cttcttcagg cgtgtcacag gtgaggttca     1080

ctgtttctcc aggggcatcg ggagtccagt ccacctctac aacataaacg tctttctcca     1140

gctcccacat ggccatgagt ggagacacca gcaaaacgat ggcaaaccag gagatggtta     1200

gcttctgagg acacatggtg gcggcgcgcc atttaaatct agccttaaga gctgtaattg     1260

aactgggagt ggacacctgt ggagagaaag gcaaagtgga tgtcagtaag accaataggt     1320

gcctatcaga aacgcaagag tcttctctgt ctcgacaagc ccagtttcta ttggtctcct     1380

taaacctgtc ttgtaacctt gatacttacc tgcccagtgc ctcacgacca acttcgatct     1440

gtaacggcgc agaacagaaa acgaaacaaa gacgtagagt tgagcaagca gggtcaggca     1500

aagcgtggag agccggctga gtctaggtag gctccaaggg agcgccggac aaaggcccgg     1560

tctcgacctg agctttaaac ttacctagac ggcggacgca gttcaggagg caccacaggc     1620

gggaggcggc agaacgcgac tcaaccggcg tggatggcgg cctcaggtag ggcggcgggc     1680

gcgtgaagga gagatgcgag cccctcgaag cttcagctgt gttctggcgg caaacccgtt     1740

gcgaaaaaga acgttcacgg cgactactgc acttatatac ggttctcccc caccctcggg     1800

aaaaaggcgg agccagtaca cgacatcact ttcccagttt accccgcgcc accttctcta     1860

ggcaccggtt caattgccga cccctccccc caacttctcg gggactgtgg gcgatgtgcg     1920

ctctgcccac tgacgggcac cggagcgatc ttaattaact agttattaat agtaatcaat     1980

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa     2040

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt     2100

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggact atttacggta     2160

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt     2220

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc     2280

tacttggcag tacatctacg tattagtcat cgctattacc atgggtgatg cggttttggc     2340

agtacatcaa tgggcgtgga tagcggtttg actcacgggg atttccaagt ctccacccca     2400

ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg ggactttcca aaatgtcgta     2460

acaactccgc cccattgacg caaatgggcg gtaggcgtgt acggtgggag gtctatataa     2520

gcagagctcg tttagtgaac cgtcagatcg cctggagacg tcgaggaact gaaaaaccag     2580

aaagttaact ggtaagttta gtctttttgt cttttatttc aggtcccgga tccggtggtg     2640

gtgcaaatca aagaactgct cctcagtgga tgttgccttt acttctaggc ctgtacggaa     2700

gtgtttaaac ttctgctctg cggccgcgcc accatggtca gcgttccaac agcctcaccc     2760

tcggcatcca gcagctcctc tcagtgccgg tccagcatgt gtcaatcacg ctacctcctc     2820

tttttggcca cccttgccct cctaaaccac ctcagtttgg ccagggtcat tccagtctct     2880

ggacctgcca ggtgtcttag ccagtcccga aacctgctga agaccacaga tgacatggtg     2940

aagacggcca gagaaaaact gaaacattat tcctgcactg ctgaagacat cgatcatgaa     3000

gacatcacac gggaccaaac cagcacattg aagacctgtt taccactgga actacacaag     3060

aacgagagtt gcctggctac tagagagact tcttccacaa caagagggag ctgcctgccc     3120

ccacagaaga cgtctttgat gatgaccctg tgccttggta gcatctatga ggacttgaag     3180

atgtaccaga cagagttcca ggccatcaac gcagcacttc agaatcacaa ccatcagcag     3240

atcattctag acaagggcat gctggtggcc atcgatgagc tgatgcagtc tctgaatcat     3300

aatggcgaga ctctgcgcca gaaacctcct gtgggagaag cagaccctta cagagtgaaa     3360

atgaagctct gcatcctgct tcacgccttc agcacccgcg tcgtgaccat caacagggtg     3420

atgggctatc tgagctccgc ctgagcccct ctccctcccc cccccctaac gttactggcc     3480

gaagccgctt ggaataaggc cggtgtgcgt ttgtctatat gttattttcc accatattgc     3540

cgtcttttgg caatgtgagg gcccggaaac ctggccctgt cttcttgacg agcattccta     3600

ggggtctttc ccctctcgcc aaaggaatgc aaggtctgtt gaatgtcgtg aaggaagcag     3660

ttcctctgga agcttcttga agacaaacaa cgtctgtagc gaccctttgc aggcagcgga     3720

accccccacc tggcgacagg tgcctctgcg gccaaaagcc acgtgtataa gatacacctg     3780

caaaggcggc acaaccccag tgccacgttg tgagttggat agttgtggaa agagtcaaat     3840

ggctctcctc aagcgtattc aacaaggggc tgaaggatgc ccagaaggta ccccattgta     3900

tgggatctga tctggggcct cggtacacat gctttacatg tgtttagtcg aggttaaaaa     3960

aacgtctagg ccccccgaac cacggggacg tggttttcct ttgaaaaaca cgatgataat     4020

atggccacaa tgaaaatttt gaaaccatat atgaggaata catccatctc gtgctacttg     4080

tgtttccttc taaacagtca ctttttaact gaggctggca ttcatgtctt cattttgggc     4140

tgtgtcagtg taggtctccc taaaacagag gccaactgga tagatgtaag atatgacctg     4200

gagaaaattg aaagccttat tcaatctatt catattgaca ccactttata cactgacagt     4260

gactttcatc ccagttgcaa agttactgca atgaactgct ttctcctgga attgcaggtt     4320

attttacatg agtacagtaa catgactctt aatgaaacag taagaaacgt gctctacctt     4380

gcaaacagca ctctgtcttc taacaagaat gtagcagaat ctggctgcaa ggaatgtgag     4440

gagctggagg agaaaacctt cacagagttt ttgcaaagct ttatacgcat tgtccaaatg     4500

ttcatcaaca cgtcctgagc ggccgcgcta gccaattgct gtgccttcta gttgccagcc     4560

atctgttgtt tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt     4620

cctttcctaa taaaatgagg aaattgcatc gcattgtctg agtaggtgtc attctattct     4680

ggggggtggg gtggggcagg acagcaaggg ggaggattgg gaagacaata gcaggcatgc     4740

tggggatgcg gtgggctcta tggagctcga gaggaacccc tagtgatgga gttggccact     4800

ccctctctgc gcgctcgctc gctcactgag gccgggcgac caaaggtcgc ccgacgcccg     4860

ggctttgccc gggcggcctc agtgagcgag cgagcgcgca gctgcagatc tg             4912


<210>  39
<211>  4626
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse EF1a - wild-type IL-15 (no CpG modification) and modified 
       IL-12B (with CpG modification) expression sequence

<400>  39
gtcgaccaca caaaaaacca acacacagat ctaatgaaaa taaagatctt ttattggcgc       60

gcctcaggat cggactctgc agggaacaca ggcccacttg ctgcaggagg aattgtaata      120

gcgatcctga gcttgcacgc agacattccc gcctttgcac tggacttcgg tagatgtctt      180

ctctacgagg aacgctcctt tctggttaca cccctcctct gtctccttca tcttttcttt      240

cttgcgctgg attcgaacaa agaacttgag ggagaagtag gaatggggag tgctccagga      300

gtcagggtac tcccagctga cctccacctg tgagttcttc aaaggcttca tctgcaagtt      360

cttgggcggg tctggtttga tgatgtccct gatgaagaag ctggtgctgt agttctcata      420

tttattctgc tgccgtgctt ccaacgccag ttcaatgggc agggtctcct cggcagttgg      480

gcaggtgaca tcctcctggc aggacactga atacttctca tagtcccttt ggtccagtgt      540

gaccttctct gcagacagag acgccattcc acatgtcact gcccgagagt caggggaact      600

gctactgctc ttgatgttga acttcaagtc catgtttctt tgcaccagcc atgagcacgt      660

gaaccgtccg gagtaatttg gtgcttcaca cttcaggaaa gtcttgtttt tgaaattttt      720

taaaatttca gtggaccaaa ttccattttc cttcttgtgg agcagcagat gtgagtggct      780

cagagtctcg cctcctttgt ggcaggtgta ctggccagca tctagaaact ctttgacagt      840

gatggtcagg gtctttccag agcctatgac tccatgtctc tggtctgagg tccaggtgat      900

gtcatcttct tcaggcgtgt cacaggtgag gttcactgtt tctccagggg catcgggagt      960

ccagtccacc tctacaacat aaacgtcttt ctccagctcc cacatggcca tgagtggaga     1020

caccagcaaa acgatggcaa accaggagat ggttagcttc tgaggacaca tggtggcggc     1080

gcgccattta aatctagcct taagagctgt aattgaactg ggagtggaca cctgtggaga     1140

gaaaggcaaa gtggatgtca gtaagaccaa taggtgccta tcagaaacgc aagagtcttc     1200

tctgtctcga caagcccagt ttctattggt ctccttaaac ctgtcttgta accttgatac     1260

ttacctgccc agtgcctcac gaccaacttc gatctgtaac ggcgcagaac agaaaacgaa     1320

acaaagacgt agagttgagc aagcagggtc aggcaaagcg tggagagccg gctgagtcta     1380

ggtaggctcc aagggagcgc cggacaaagg cccggtctcg acctgagctt taaacttacc     1440

tagacggcgg acgcagttca ggaggcacca caggcgggag gcggcagaac gcgactcaac     1500

cggcgtggat ggcggcctca ggtagggcgg cgggcgcgtg aaggagagat gcgagcccct     1560

cgaagcttca gctgtgttct ggcggcaaac ccgttgcgaa aaagaacgtt cacggcgact     1620

actgcactta tatacggttc tcccccaccc tcgggaaaaa ggcggagcca gtacacgaca     1680

tcactttccc agtttacccc gcgccacctt ctctaggcac cggttcaatt gccgacccct     1740

ccccccaact tctcggggac tgtgggcgat gtgcgctctg cccactgacg ggcaccggag     1800

cgatcttaat taactagtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca     1860

tatatggagt tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac     1920

gacccccgcc cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact     1980

ttccattgac gtcaatgggt ggactattta cggtaaactg cccacttggc agtacatcaa     2040

gtgtatcata tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg     2100

cattatgccc agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta     2160

gtcatcgcta ttaccatggg tgatgcggtt ttggcagtac atcaatgggc gtggatagcg     2220

gtttgactca cggggatttc caagtctcca ccccattgac gtcaatggga gtttgttttg     2280

gcaccaaaat caacgggact ttccaaaatg tcgtaacaac tccgccccat tgacgcaaat     2340

gggcggtagg cgtgtacggt gggaggtcta tataagcaga gctcgtttag tgaaccgtca     2400

gatcgcctgg agacgtcgag gaactgaaaa accagaaagt taactggtaa gtttagtctt     2460

tttgtctttt atttcaggtc ccggatccgg tggtggtgca aatcaaagaa ctgctcctca     2520

gtggatgttg cctttacttc taggcctgta cggaagtgtt taaacttctg ctctgcggcc     2580

gcgccaccat ggtcagcgtt ccaacagcct caccctcggc atccagcagc tcctctcagt     2640

gccggtccag catgtgtcaa tcacgctacc tcctcttttt ggccaccctt gccctcctaa     2700

accacctcag tttggccagg gtcattccag tctctggacc tgccaggtgt cttagccagt     2760

cccgaaacct gctgaagacc acagatgaca tggtgaagac ggccagagaa aaactgaaac     2820

attattcctg cactgctgaa gacatcgatc atgaagacat cacacgggac caaaccagca     2880

cattgaagac ctgtttacca ctggaactac acaagaacga gagttgcctg gctactagag     2940

agacttcttc cacaacaaga gggagctgcc tgcccccaca gaagacgtct ttgatgatga     3000

ccctgtgcct tggtagcatc tatgaggact tgaagatgta ccagacagag ttccaggcca     3060

tcaacgcagc acttcagaat cacaaccatc agcagatcat tctagacaag ggcatgctgg     3120

tggccatcga tgagctgatg cagtctctga atcataatgg cgagactctg cgccagaaac     3180

ctcctgtggg agaagcagac ccttacagag tgaaaatgaa gctctgcatc ctgcttcacg     3240

ccttcagcac ccgcgtcgtg accatcaaca gggtgatggg ctatctgagc tccgcctgag     3300

cccctctccc tccccccccc ctaacgttac tggccgaagc cgcttggaat aaggccggtg     3360

tgcgtttgtc tatatgttat tttccaccat attgccgtct tttggcaatg tgagggcccg     3420

gaaacctggc cctgtcttct tgacgagcat tcctaggggt ctttcccctc tcgccaaagg     3480

aatgcaaggt ctgttgaatg tcgtgaagga agcagttcct ctggaagctt cttgaagaca     3540

aacaacgtct gtagcgaccc tttgcaggca gcggaacccc ccacctggcg acaggtgcct     3600

ctgcggccaa aagccacgtg tataagatac acctgcaaag gcggcacaac cccagtgcca     3660

cgttgtgagt tggatagttg tggaaagagt caaatggctc tcctcaagcg tattcaacaa     3720

ggggctgaag gatgcccaga aggtacccca ttgtatggga tctgatctgg ggcctcggta     3780

cacatgcttt acatgtgttt agtcgaggtt aaaaaaacgt ctaggccccc cgaaccacgg     3840

ggacgtggtt ttcctttgaa aaacacgatg ataatatggc cacaatgaaa attttgaaac     3900

catatatgag gaatacatcc atctcgtgct acttgtgttt ccttctaaac agtcactttt     3960

taactgaggc tggcattcat gtcttcattt tgggctgtgt cagtgtaggt ctccctaaaa     4020

cagaggccaa ctggatagat gtaagatatg acctggagaa aattgaaagc cttattcaat     4080

ctattcatat tgacaccact ttatacactg acagtgactt tcatcccagt tgcaaagtta     4140

ctgcaatgaa ctgctttctc ctggaattgc aggttatttt acatgagtac agtaacatga     4200

ctcttaatga aacagtaaga aacgtgctct accttgcaaa cagcactctg tcttctaaca     4260

agaatgtagc agaatctggc tgcaaggaat gtgaggagct ggaggagaaa accttcacag     4320

agtttttgca aagctttata cgcattgtcc aaatgttcat caacacgtcc tgagcggccg     4380

cgctagccaa ttgctgtgcc ttctagttgc cagccatctg ttgtttgccc ctcccccgtg     4440

ccttccttga ccctggaagg tgccactccc actgtccttt cctaataaaa tgaggaaatt     4500

gcatcgcatt gtctgagtag gtgtcattct attctggggg gtggggtggg gcaggacagc     4560

aagggggagg attgggaaga caatagcagg catgctgggg atgcggtggg ctctatggag     4620

ctcgag                                                                4626


<210>  40
<211>  4912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse EF1a - modified IL-12B/IL-15 (CpG modified) construct

<400>  40
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tagtattaaa cgcgtgtcga ccacacaaaa aaccaacaca cagatctaat      180

gaaaataaag atcttttatt ggcgcgcctc aggacctgac tctgcaggga acacatgccc      240

acttgctgca ggaggaattg taatatctat cctgagcttg cacacagaca ttcccacctt      300

tgcattggac ttctgtagat gtcttctcta caaggaaggc acctttctgg ttacacccct      360

cctctgtctc cttcatcttt tctttcttcc tctggattct aacaaagaac ttgagggaga      420

agtaggaatg gggagtgctc caggagtcag ggtactccca gctgacctcc acctgtgagt      480

tcttcaaagg cttcatctgc aagttcttgg gggggtctgg tttgatgatg tccctgatga      540

agaagctggt gctgtagttc tcatatttat tctgctgcct tgcttccaag gccagttcaa      600

tgggcagggt ctcctcagca gttgggcagg tgacatcctc ctggcaggac actgaatact      660

tctcatagtc cctttggtcc agtgtgacct tctctgcaga cagagaagcc attccacatg      720

tcactgctct agagtcaggg gaactgctac tgctcttgat gttgaacttc aagtccatgt      780

ttctttgcac cagccatgag catgtgaatc ttccactgta atttggtgct tcacacttca      840

ggaaagtctt gtttttgaaa ttttttaaaa tttcagtgga ccaaattcca ttttccttct      900

tgtggagcag cagatgtgag tggctcagag tctcccctcc tttgtggcag gtgtactggc      960

cagcatctag aaactctttg acagtgatgg tcagggtctt tccagagcct atgactccat     1020

gtctctggtc tgaggtccag gtgatgtcat cttcttcagg tgtgtcacag gtgaggttca     1080

ctgtttctcc aggggcatct ggagtccagt ccacctctac aacataaaca tctttctcca     1140

gctcccacat ggccatgagt ggagacacca gcaaaacaat ggcaaaccag gagatggtta     1200

gcttctgagg acacatggtg gcggcgcgcc atttaaatct agccttaaga gctgtaattg     1260

aactgggagt ggacacctgt ggagagaaag gcaaagtgga tgtcagtaag accaataggt     1320

gcctatcaga aacgcaagag tcttctctgt ctcgacaagc ccagtttcta ttggtctcct     1380

taaacctgtc ttgtaacctt gatacttacc tgcccagtgc ctcacgacca acttcgatct     1440

gtaacggcgc agaacagaaa acgaaacaaa gacgtagagt tgagcaagca gggtcaggca     1500

aagcgtggag agccggctga gtctaggtag gctccaaggg agcgccggac aaaggcccgg     1560

tctcgacctg agctttaaac ttacctagac ggcggacgca gttcaggagg caccacaggc     1620

gggaggcggc agaacgcgac tcaaccggcg tggatggcgg cctcaggtag ggcggcgggc     1680

gcgtgaagga gagatgcgag cccctcgaag cttcagctgt gttctggcgg caaacccgtt     1740

gcgaaaaaga acgttcacgg cgactactgc acttatatac ggttctcccc caccctcggg     1800

aaaaaggcgg agccagtaca cgacatcact ttcccagttt accccgcgcc accttctcta     1860

ggcaccggtt caattgccga cccctccccc caacttctcg gggactgtgg gcgatgtgcg     1920

ctctgcccac tgacgggcac cggagcgatc ttaattaact agttattaat agtaatcaat     1980

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa     2040

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt     2100

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggact atttacggta     2160

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt     2220

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc     2280

tacttggcag tacatctacg tattagtcat cgctattacc atgggtgatg cggttttggc     2340

agtacatcaa tgggcgtgga tagcggtttg actcacgggg atttccaagt ctccacccca     2400

ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg ggactttcca aaatgtcgta     2460

acaactccgc cccattgacg caaatgggcg gtaggcgtgt acggtgggag gtctatataa     2520

gcagagctcg tttagtgaac cgtcagatcg cctggagacg tcgaggaact gaaaaaccag     2580

aaagttaact ggtaagttta gtctttttgt cttttatttc aggtcccgga tccggtggtg     2640

gtgcaaatca aagaactgct cctcagtgga tgttgccttt acttctaggc ctgtacggaa     2700

gtgtttaaac ttctgctctg cggccgcgcc accatggtca gtgttccaac agcctcaccc     2760

tcagcatcca gcagctcctc tcagtgcagg tccagcatgt gtcaatcaag atacctcctc     2820

tttttggcca cccttgccct cctaaaccac ctcagtttgg ccagggtcat tccagtctct     2880

ggacctgcca ggtgtcttag ccagtccagg aacctgctga agaccacaga tgacatggtg     2940

aagactgcca gagaaaaact gaaacattat tcctgcactg ctgaagacat agatcatgaa     3000

gacatcacaa gagaccaaac cagcacattg aagacctgtt taccactgga actacacaag     3060

aatgagagtt gcctggctac tagagagact tcttccacaa caagagggag ctgcctgccc     3120

ccacagaaga cctctttgat gatgaccctg tgccttggta gcatctatga ggacttgaag     3180

atgtaccaga cagagttcca ggccatcaat gcagcacttc agaatcacaa ccatcagcag     3240

atcattctag acaagggcat gctggtggcc attgatgagc tgatgcagtc tctgaatcat     3300

aatggggaga ctctgaggca gaaacctcct gtgggagaag cagaccctta cagagtgaaa     3360

atgaagctct gcatcctgct tcatgccttc agcaccagag tagtgaccat caacagggtg     3420

atgggctatc tgagcagtgc ctgagcccct ctccctcccc cccccctaac gttactggcc     3480

gaagccgctt ggaataaggc cggtgtgcgt ttgtctatat gttattttcc accatattgc     3540

cgtcttttgg caatgtgagg gcccggaaac ctggccctgt cttcttgacg agcattccta     3600

ggggtctttc ccctctcgcc aaaggaatgc aaggtctgtt gaatgtcgtg aaggaagcag     3660

ttcctctgga agcttcttga agacaaacaa cgtctgtagc gaccctttgc aggcagcgga     3720

accccccacc tggcgacagg tgcctctgcg gccaaaagcc acgtgtataa gatacacctg     3780

caaaggcggc acaaccccag tgccacgttg tgagttggat agttgtggaa agagtcaaat     3840

ggctctcctc aagcgtattc aacaaggggc tgaaggatgc ccagaaggta ccccattgta     3900

tgggatctga tctggggcct cggtacacat gctttacatg tgtttagtcg aggttaaaaa     3960

aacgtctagg ccccccgaac cacggggacg tggttttcct ttgaaaaaca cgatgataat     4020

atggccacaa tgaaaatttt gaaaccatat atgaggaata catccatctc atgctacttg     4080

tgtttccttc taaacagtca ctttttaact gaggctggca ttcatgtctt cattttgggc     4140

tgtgtcagtg taggtctccc taaaacagag gccaactgga tagatgtaag atatgacctg     4200

gagaaaattg aaagccttat tcaatctatt catattgaca ccactttata cactgacagt     4260

gactttcatc ccagttgcaa agttactgca atgaactgct ttctcctgga attgcaggtt     4320

attttacatg agtacagtaa catgactctt aatgaaacag taagaaatgt gctctacctt     4380

gcaaacagca ctctgtcttc taacaagaat gtagcagaat ctggctgcaa ggaatgtgag     4440

gagctggagg agaaaacctt cacagagttt ttgcaaagct ttataaggat tgtccaaatg     4500

ttcatcaaca cctcctgagc ggccgcgcta gccaattgct gtgccttcta gttgccagcc     4560

atctgttgtt tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt     4620

cctttcctaa taaaatgagg aaattgcatc gcattgtctg agtaggtgtc attctattct     4680

ggggggtggg gtggggcagg acagcaaggg ggaggattgg gaagacaata gcaggcatgc     4740

tggggatgcg gtgggctcta tggagctcga gaggaacccc tagtgatgga gttggccact     4800

ccctctctgc gcgctcgctc gctcactgag gccgggcgac caaaggtcgc ccgacgcccg     4860

ggctttgccc gggcggcctc agtgagcgag cgagcgcgca gctgcagatc tg             4912


<210>  41
<211>  4626
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse EF1a - modified IL-12B/IL-15 (CpG modified) expression 
       sequence

<400>  41
gtcgaccaca caaaaaacca acacacagat ctaatgaaaa taaagatctt ttattggcgc       60

gcctcaggac ctgactctgc agggaacaca tgcccacttg ctgcaggagg aattgtaata      120

tctatcctga gcttgcacac agacattccc acctttgcat tggacttctg tagatgtctt      180

ctctacaagg aaggcacctt tctggttaca cccctcctct gtctccttca tcttttcttt      240

cttcctctgg attctaacaa agaacttgag ggagaagtag gaatggggag tgctccagga      300

gtcagggtac tcccagctga cctccacctg tgagttcttc aaaggcttca tctgcaagtt      360

cttggggggg tctggtttga tgatgtccct gatgaagaag ctggtgctgt agttctcata      420

tttattctgc tgccttgctt ccaaggccag ttcaatgggc agggtctcct cagcagttgg      480

gcaggtgaca tcctcctggc aggacactga atacttctca tagtcccttt ggtccagtgt      540

gaccttctct gcagacagag aagccattcc acatgtcact gctctagagt caggggaact      600

gctactgctc ttgatgttga acttcaagtc catgtttctt tgcaccagcc atgagcatgt      660

gaatcttcca ctgtaatttg gtgcttcaca cttcaggaaa gtcttgtttt tgaaattttt      720

taaaatttca gtggaccaaa ttccattttc cttcttgtgg agcagcagat gtgagtggct      780

cagagtctcc cctcctttgt ggcaggtgta ctggccagca tctagaaact ctttgacagt      840

gatggtcagg gtctttccag agcctatgac tccatgtctc tggtctgagg tccaggtgat      900

gtcatcttct tcaggtgtgt cacaggtgag gttcactgtt tctccagggg catctggagt      960

ccagtccacc tctacaacat aaacatcttt ctccagctcc cacatggcca tgagtggaga     1020

caccagcaaa acaatggcaa accaggagat ggttagcttc tgaggacaca tggtggcggc     1080

gcgccattta aatctagcct taagagctgt aattgaactg ggagtggaca cctgtggaga     1140

gaaaggcaaa gtggatgtca gtaagaccaa taggtgccta tcagaaacgc aagagtcttc     1200

tctgtctcga caagcccagt ttctattggt ctccttaaac ctgtcttgta accttgatac     1260

ttacctgccc agtgcctcac gaccaacttc gatctgtaac ggcgcagaac agaaaacgaa     1320

acaaagacgt agagttgagc aagcagggtc aggcaaagcg tggagagccg gctgagtcta     1380

ggtaggctcc aagggagcgc cggacaaagg cccggtctcg acctgagctt taaacttacc     1440

tagacggcgg acgcagttca ggaggcacca caggcgggag gcggcagaac gcgactcaac     1500

cggcgtggat ggcggcctca ggtagggcgg cgggcgcgtg aaggagagat gcgagcccct     1560

cgaagcttca gctgtgttct ggcggcaaac ccgttgcgaa aaagaacgtt cacggcgact     1620

actgcactta tatacggttc tcccccaccc tcgggaaaaa ggcggagcca gtacacgaca     1680

tcactttccc agtttacccc gcgccacctt ctctaggcac cggttcaatt gccgacccct     1740

ccccccaact tctcggggac tgtgggcgat gtgcgctctg cccactgacg ggcaccggag     1800

cgatcttaat taactagtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca     1860

tatatggagt tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac     1920

gacccccgcc cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact     1980

ttccattgac gtcaatgggt ggactattta cggtaaactg cccacttggc agtacatcaa     2040

gtgtatcata tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg     2100

cattatgccc agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta     2160

gtcatcgcta ttaccatggg tgatgcggtt ttggcagtac atcaatgggc gtggatagcg     2220

gtttgactca cggggatttc caagtctcca ccccattgac gtcaatggga gtttgttttg     2280

gcaccaaaat caacgggact ttccaaaatg tcgtaacaac tccgccccat tgacgcaaat     2340

gggcggtagg cgtgtacggt gggaggtcta tataagcaga gctcgtttag tgaaccgtca     2400

gatcgcctgg agacgtcgag gaactgaaaa accagaaagt taactggtaa gtttagtctt     2460

tttgtctttt atttcaggtc ccggatccgg tggtggtgca aatcaaagaa ctgctcctca     2520

gtggatgttg cctttacttc taggcctgta cggaagtgtt taaacttctg ctctgcggcc     2580

gcgccaccat ggtcagtgtt ccaacagcct caccctcagc atccagcagc tcctctcagt     2640

gcaggtccag catgtgtcaa tcaagatacc tcctcttttt ggccaccctt gccctcctaa     2700

accacctcag tttggccagg gtcattccag tctctggacc tgccaggtgt cttagccagt     2760

ccaggaacct gctgaagacc acagatgaca tggtgaagac tgccagagaa aaactgaaac     2820

attattcctg cactgctgaa gacatagatc atgaagacat cacaagagac caaaccagca     2880

cattgaagac ctgtttacca ctggaactac acaagaatga gagttgcctg gctactagag     2940

agacttcttc cacaacaaga gggagctgcc tgcccccaca gaagacctct ttgatgatga     3000

ccctgtgcct tggtagcatc tatgaggact tgaagatgta ccagacagag ttccaggcca     3060

tcaatgcagc acttcagaat cacaaccatc agcagatcat tctagacaag ggcatgctgg     3120

tggccattga tgagctgatg cagtctctga atcataatgg ggagactctg aggcagaaac     3180

ctcctgtggg agaagcagac ccttacagag tgaaaatgaa gctctgcatc ctgcttcatg     3240

ccttcagcac cagagtagtg accatcaaca gggtgatggg ctatctgagc agtgcctgag     3300

cccctctccc tccccccccc ctaacgttac tggccgaagc cgcttggaat aaggccggtg     3360

tgcgtttgtc tatatgttat tttccaccat attgccgtct tttggcaatg tgagggcccg     3420

gaaacctggc cctgtcttct tgacgagcat tcctaggggt ctttcccctc tcgccaaagg     3480

aatgcaaggt ctgttgaatg tcgtgaagga agcagttcct ctggaagctt cttgaagaca     3540

aacaacgtct gtagcgaccc tttgcaggca gcggaacccc ccacctggcg acaggtgcct     3600

ctgcggccaa aagccacgtg tataagatac acctgcaaag gcggcacaac cccagtgcca     3660

cgttgtgagt tggatagttg tggaaagagt caaatggctc tcctcaagcg tattcaacaa     3720

ggggctgaag gatgcccaga aggtacccca ttgtatggga tctgatctgg ggcctcggta     3780

cacatgcttt acatgtgttt agtcgaggtt aaaaaaacgt ctaggccccc cgaaccacgg     3840

ggacgtggtt ttcctttgaa aaacacgatg ataatatggc cacaatgaaa attttgaaac     3900

catatatgag gaatacatcc atctcatgct acttgtgttt ccttctaaac agtcactttt     3960

taactgaggc tggcattcat gtcttcattt tgggctgtgt cagtgtaggt ctccctaaaa     4020

cagaggccaa ctggatagat gtaagatatg acctggagaa aattgaaagc cttattcaat     4080

ctattcatat tgacaccact ttatacactg acagtgactt tcatcccagt tgcaaagtta     4140

ctgcaatgaa ctgctttctc ctggaattgc aggttatttt acatgagtac agtaacatga     4200

ctcttaatga aacagtaaga aatgtgctct accttgcaaa cagcactctg tcttctaaca     4260

agaatgtagc agaatctggc tgcaaggaat gtgaggagct ggaggagaaa accttcacag     4320

agtttttgca aagctttata aggattgtcc aaatgttcat caacacctcc tgagcggccg     4380

cgctagccaa ttgctgtgcc ttctagttgc cagccatctg ttgtttgccc ctcccccgtg     4440

ccttccttga ccctggaagg tgccactccc actgtccttt cctaataaaa tgaggaaatt     4500

gcatcgcatt gtctgagtag gtgtcattct attctggggg gtggggtggg gcaggacagc     4560

aagggggagg attgggaaga caatagcagg catgctgggg atgcggtggg ctctatggag     4620

ctcgag                                                                4626


<210>  42
<211>  4581
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse CAG - wild-type IL-12B - IRES (not CpG modified) construct

<400>  42
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tagtattaaa cgcgtgtcga cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggg tcgaggtgag      540

ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa ttttgtattt      600

atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg cgcgcgccag      660

gcggggcggg gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca      720

atcagagcgg cgcgctccga aagtttcctt ttatggcgag gcggcggcgg cggcggccct      780

ataaaaagcg aagcgcgcgg cgggcgggag tcgctgcgcg ctgccttcgc cccgtgcccc      840

gctccgccgc cgcctcgcgc cgcccgcccc ggctctgact gaccgcgtta ctcccacagg      900

tgagcgggcg ggacggccct tctcctccgg gctgtaatta gcgcttggtt taatgacggc      960

tcgtttcttt tctgtggctg cgtgaaagcc ttgaggggct ccgggagggc cctttgtgcg     1020

gggggagcgg ctcggggggt gcgtgcgtgt gtgtgtgcgt ggggagcgcc gcgtgcggct     1080

ccgcgctgcc cggcggctgt gagcgctgcg ggcgcggcgc ggggctttgt gcgctccgca     1140

gtgtgcgcga gaggagcgcg gccgggggcg gtgccacgcg gtgcgggggg ggctgcgagg     1200

ggaacaaagg ctgcgtgcgg ggtgtgtgcg tggggggggt gagcaggggg tgtgggcgcg     1260

gcggtcgggc tgtaaccccc ccctgcaccc ccctccccga gttgctgagc acggcccggc     1320

ttcgggtgcg gggctccgtg cggggcgtgg cgcggggctc gccgtgccgg gcggggggtg     1380

gcggcgggtg ggggtgccgg gcggggcggg gccgcctcgg gccggggagg gctcggggga     1440

ggggcgcggc ggcccccgga gcgccggcgg ctgtcgaggc gcggcgagcc gcagccattg     1500

ccttttatgg taatcgtgcg agagggcgca gggacttcct ttgtcccaaa tctgtgcgga     1560

gccgaaatct gggaggcgcc gccgcacccc ctctagcggg cgcggggcga agcggtgcgg     1620

cgccggcagg aaggaaatgg gcggggaggg ccttcgtgcg tcgccgcgcc gccgtcccct     1680

tctccctctc cagcctcggg gctgtccgcg gggggacggc tgccttcggg ggggacgggg     1740

cagggcgggg ttcggcttct ggcgtgtgac cggcggtcta gactctgcta accatgttca     1800

tgccttcttc tctttcctac agctcctggg caacgtgctg gttgttgtgc tgtctcatca     1860

ttttggcaaa gaattcaagc ttccagctag cgccaccatg gtcagcgttc caacagcctc     1920

accctcggca tccagcagct cctctcagtg ccggtccagc atgtgtcaat cacgctacct     1980

cctctttttg gccacccttg ccctcctaaa ccacctcagt ttggccaggg tcattccagt     2040

ctctggacct gccaggtgtc ttagccagtc ccgaaacctg ctgaagacca cagatgacat     2100

ggtgaagacg gccagagaaa aactgaaaca ttattcctgc actgctgaag acatcgatca     2160

tgaagacatc acacgggacc aaaccagcac attgaagacc tgtttaccac tggaactaca     2220

caagaacgag agttgcctgg ctactagaga gacttcttcc acaacaagag ggagctgcct     2280

gcccccacag aagacgtctt tgatgatgac cctgtgcctt ggtagcatct atgaggactt     2340

gaagatgtac cagacagagt tccaggccat caacgcagca cttcagaatc acaaccatca     2400

gcagatcatt ctagacaagg gcatgctggt ggccatcgat gagctgatgc agtctctgaa     2460

tcataatggc gagactctgc gccagaaacc tcctgtggga gaagcagacc cttacagagt     2520

gaaaatgaag ctctgcatcc tgcttcacgc cttcagcacc cgcgtcgtga ccatcaacag     2580

ggtgatgggc tatctgagct ccgcctgagc ccctctccct cccccccccc taacgttact     2640

ggccgaagcc gcttggaata aggccggtgt gcgtttgtct atatgttatt ttccaccata     2700

ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt gacgagcatt     2760

cctaggggtc tttcccctct cgccaaagga atgcaaggtc tgttgaatgt cgtgaaggaa     2820

gcagttcctc tggaagcttc ttgaagacaa acaacgtctg tagcgaccct ttgcaggcag     2880

cggaaccccc cacctggcga caggtgcctc tgcggccaaa agccacgtgt ataagataca     2940

cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt ggatagttgt ggaaagagtc     3000

aaatggctct cctcaagcgt attcaacaag gggctgaagg atgcccagaa ggtaccccat     3060

tgtatgggat ctgatctggg gcctcggtac acatgcttta catgtgttta gtcgaggtta     3120

aaaaaacgtc taggcccccc gaaccacggg gacgtggttt tcctttgaaa aacacgatga     3180

taatatggcc acaatgtgtc ctcagaagct aaccatctcc tggtttgcca tcgttttgct     3240

ggtgtctcca ctcatggcca tgtgggagct ggagaaagac gtttatgttg tagaggtgga     3300

ctggactccc gatgcccctg gagaaacagt gaacctcacc tgtgacacgc ctgaagaaga     3360

tgacatcacc tggacctcag accagagaca tggagtcata ggctctggaa agaccctgac     3420

catcactgtc aaagagtttc tagatgctgg ccagtacacc tgccacaaag gaggcgagac     3480

tctgagccac tcacatctgc tgctccacaa gaaggaaaat ggaatttggt ccactgaaat     3540

tttaaaaaat ttcaaaaaca agactttcct gaagtgtgaa gcaccaaatt actccggacg     3600

gttcacgtgc tcatggctgg tgcaaagaaa catggacttg aagttcaaca tcaagagcag     3660

tagcagttcc cctgactctc gggcagtgac atgtggaatg gcgtctctgt ctgcagagaa     3720

ggtcacactg gaccaaaggg actatgagaa gtattcagtg tcctgccagg aggatgtcac     3780

ctgcccaact gccgaggaga ccctgcccat tgaactggcg ttggaagcac ggcagcagaa     3840

taaatatgag aactacagca ccagcttctt catcagggac atcatcaaac cagacccgcc     3900

caagaacttg cagatgaagc ctttgaagaa ctcacaggtg gaggtcagct gggagtaccc     3960

tgactcctgg agcactcccc attcctactt ctccctcaag ttctttgttc gaatccagcg     4020

caagaaagaa aagatgaagg agacagagga ggggtgtaac cagaaaggag cgttcctcgt     4080

agagaagaca tctaccgaag tccaatgcaa aggcgggaat gtctgcgtgc aagctcagga     4140

tcgctattac aattcctcat gcagcaagtg ggcatgtgtt ccctgcaggg tccgatcctg     4200

acaattgctg tgccttctag ttgccagcca tctgttgttt gcccctcccc cgtgccttcc     4260

ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga aattgcatcg     4320

cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga cagcaagggg     4380

gaggattggg aagacaatag caggcatgct ggggatgcgg tgggctctat ggagctcgag     4440

aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg     4500

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc     4560

gagcgcgcag ctgcagatct g                                               4581


<210>  43
<211>  2322
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse CAG - wild-type IL-12B - IRES (not CpG modified) expression
       sequence

<400>  43
gctagcgcca ccatggtcag cgttccaaca gcctcaccct cggcatccag cagctcctct       60

cagtgccggt ccagcatgtg tcaatcacgc tacctcctct ttttggccac ccttgccctc      120

ctaaaccacc tcagtttggc cagggtcatt ccagtctctg gacctgccag gtgtcttagc      180

cagtcccgaa acctgctgaa gaccacagat gacatggtga agacggccag agaaaaactg      240

aaacattatt cctgcactgc tgaagacatc gatcatgaag acatcacacg ggaccaaacc      300

agcacattga agacctgttt accactggaa ctacacaaga acgagagttg cctggctact      360

agagagactt cttccacaac aagagggagc tgcctgcccc cacagaagac gtctttgatg      420

atgaccctgt gccttggtag catctatgag gacttgaaga tgtaccagac agagttccag      480

gccatcaacg cagcacttca gaatcacaac catcagcaga tcattctaga caagggcatg      540

ctggtggcca tcgatgagct gatgcagtct ctgaatcata atggcgagac tctgcgccag      600

aaacctcctg tgggagaagc agacccttac agagtgaaaa tgaagctctg catcctgctt      660

cacgccttca gcacccgcgt cgtgaccatc aacagggtga tgggctatct gagctccgcc      720

tgagcccctc tccctccccc ccccctaacg ttactggccg aagccgcttg gaataaggcc      780

ggtgtgcgtt tgtctatatg ttattttcca ccatattgcc gtcttttggc aatgtgaggg      840

cccggaaacc tggccctgtc ttcttgacga gcattcctag gggtctttcc cctctcgcca      900

aaggaatgca aggtctgttg aatgtcgtga aggaagcagt tcctctggaa gcttcttgaa      960

gacaaacaac gtctgtagcg accctttgca ggcagcggaa ccccccacct ggcgacaggt     1020

gcctctgcgg ccaaaagcca cgtgtataag atacacctgc aaaggcggca caaccccagt     1080

gccacgttgt gagttggata gttgtggaaa gagtcaaatg gctctcctca agcgtattca     1140

acaaggggct gaaggatgcc cagaaggtac cccattgtat gggatctgat ctggggcctc     1200

ggtacacatg ctttacatgt gtttagtcga ggttaaaaaa acgtctaggc cccccgaacc     1260

acggggacgt ggttttcctt tgaaaaacac gatgataata tggccacaat gtgtcctcag     1320

aagctaacca tctcctggtt tgccatcgtt ttgctggtgt ctccactcat ggccatgtgg     1380

gagctggaga aagacgttta tgttgtagag gtggactgga ctcccgatgc ccctggagaa     1440

acagtgaacc tcacctgtga cacgcctgaa gaagatgaca tcacctggac ctcagaccag     1500

agacatggag tcataggctc tggaaagacc ctgaccatca ctgtcaaaga gtttctagat     1560

gctggccagt acacctgcca caaaggaggc gagactctga gccactcaca tctgctgctc     1620

cacaagaagg aaaatggaat ttggtccact gaaattttaa aaaatttcaa aaacaagact     1680

ttcctgaagt gtgaagcacc aaattactcc ggacggttca cgtgctcatg gctggtgcaa     1740

agaaacatgg acttgaagtt caacatcaag agcagtagca gttcccctga ctctcgggca     1800

gtgacatgtg gaatggcgtc tctgtctgca gagaaggtca cactggacca aagggactat     1860

gagaagtatt cagtgtcctg ccaggaggat gtcacctgcc caactgccga ggagaccctg     1920

cccattgaac tggcgttgga agcacggcag cagaataaat atgagaacta cagcaccagc     1980

ttcttcatca gggacatcat caaaccagac ccgcccaaga acttgcagat gaagcctttg     2040

aagaactcac aggtggaggt cagctgggag taccctgact cctggagcac tccccattcc     2100

tacttctccc tcaagttctt tgttcgaatc cagcgcaaga aagaaaagat gaaggagaca     2160

gaggaggggt gtaaccagaa aggagcgttc ctcgtagaga agacatctac cgaagtccaa     2220

tgcaaaggcg ggaatgtctg cgtgcaagct caggatcgct attacaattc ctcatgcagc     2280

aagtgggcat gtgttccctg cagggtccga tcctgacaat tg                        2322


<210>  44
<211>  2766
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse CAG - wild-type IL-15 (not CpG modified) construct

<400>  44
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tagtattaaa cgcgtgtcga cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggg tcgaggtgag      540

ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa ttttgtattt      600

atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg cgcgcgccag      660

gcggggcggg gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca      720

atcagagcgg cgcgctccga aagtttcctt ttatggcgag gcggcggcgg cggcggccct      780

ataaaaagcg aagcgcgcgg cgggcgggag tcgctgcgcg ctgccttcgc cccgtgcccc      840

gctccgccgc cgcctcgcgc cgcccgcccc ggctctgact gaccgcgtta ctcccacagg      900

tgagcgggcg ggacggccct tctcctccgg gctgtaatta gcgcttggtt taatgacggc      960

tcgtttcttt tctgtggctg cgtgaaagcc ttgaggggct ccgggagggc cctttgtgcg     1020

gggggagcgg ctcggggggt gcgtgcgtgt gtgtgtgcgt ggggagcgcc gcgtgcggct     1080

ccgcgctgcc cggcggctgt gagcgctgcg ggcgcggcgc ggggctttgt gcgctccgca     1140

gtgtgcgcga gaggagcgcg gccgggggcg gtgccacgcg gtgcgggggg ggctgcgagg     1200

ggaacaaagg ctgcgtgcgg ggtgtgtgcg tggggggggt gagcaggggg tgtgggcgcg     1260

gcggtcgggc tgtaaccccc ccctgcaccc ccctccccga gttgctgagc acggcccggc     1320

ttcgggtgcg gggctccgtg cggggcgtgg cgcggggctc gccgtgccgg gcggggggtg     1380

gcggcgggtg ggggtgccgg gcggggcggg gccgcctcgg gccggggagg gctcggggga     1440

ggggcgcggc ggcccccgga gcgccggcgg ctgtcgaggc gcggcgagcc gcagccattg     1500

ccttttatgg taatcgtgcg agagggcgca gggacttcct ttgtcccaaa tctgtgcgga     1560

gccgaaatct gggaggcgcc gccgcacccc ctctagcggg cgcggggcga agcggtgcgg     1620

cgccggcagg aaggaaatgg gcggggaggg ccttcgtgcg tcgccgcgcc gccgtcccct     1680

tctccctctc cagcctcggg gctgtccgcg gggggacggc tgccttcggg ggggacgggg     1740

cagggcgggg ttcggcttct ggcgtgtgac cggcggtcta gactctgcta accatgttca     1800

tgccttcttc tctttcctac agctcctggg caacgtgctg gttgttgtgc tgtctcatca     1860

ttttggcaaa gaattcaagc ttccagctag cgccaccatg aaaattttga aaccatatat     1920

gaggaataca tccatctcgt gctacttgtg tttccttcta aacagtcact ttttaactga     1980

ggctggcatt catgtcttca ttttgggctg tgtcagtgta ggtctcccta aaacagaggc     2040

caactggata gatgtaagat atgacctgga gaaaattgaa agccttattc aatctattca     2100

tattgacacc actttataca ctgacagtga ctttcatccc agttgcaaag ttactgcaat     2160

gaactgcttt ctcctggaat tgcaggttat tttacatgag tacagtaaca tgactcttaa     2220

tgaaacagta agaaacgtgc tctaccttgc aaacagcact ctgtcttcta acaagaatgt     2280

agcagaatct ggctgcaagg aatgtgagga gctggaggag aaaaccttca cagagttttt     2340

gcaaagcttt atacgcattg tccaaatgtt catcaacacg tcctgacaat tgctgtgcct     2400

tctagttgcc agccatctgt tgtttgcccc tcccccgtgc cttccttgac cctggaaggt     2460

gccactccca ctgtcctttc ctaataaaat gaggaaattg catcgcattg tctgagtagg     2520

tgtcattcta ttctgggggg tggggtgggg caggacagca agggggagga ttgggaagac     2580

aatagcaggc atgctgggga tgcggtgggc tctatggagc tcgagaggaa cccctagtga     2640

tggagttggc cactccctct ctgcgcgctc gctcgctcac tgaggccggg cgaccaaagg     2700

tcgcccgacg cccgggcttt gcccgggcgg cctcagtgag cgagcgagcg cgcagctgca     2760

gatctg                                                                2766


<210>  45
<211>  507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse CAG - wild-type IL-15 (not CpG modified) expression 
       sequence

<400>  45
gctagcgcca ccatgaaaat tttgaaacca tatatgagga atacatccat ctcgtgctac       60

ttgtgtttcc ttctaaacag tcacttttta actgaggctg gcattcatgt cttcattttg      120

ggctgtgtca gtgtaggtct ccctaaaaca gaggccaact ggatagatgt aagatatgac      180

ctggagaaaa ttgaaagcct tattcaatct attcatattg acaccacttt atacactgac      240

agtgactttc atcccagttg caaagttact gcaatgaact gctttctcct ggaattgcag      300

gttattttac atgagtacag taacatgact cttaatgaaa cagtaagaaa cgtgctctac      360

cttgcaaaca gcactctgtc ttctaacaag aatgtagcag aatctggctg caaggaatgt      420

gaggagctgg aggagaaaac cttcacagag tttttgcaaa gctttatacg cattgtccaa      480

atgttcatca acacgtcctg acaattg                                          507


<210>  46
<211>  4089
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse CAG - wild-type IL-12B - F2A (not CpG modified) construct

<400>  46
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tagtattaaa cgcgtgtcga cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggg tcgaggtgag      540

ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa ttttgtattt      600

atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg cgcgcgccag      660

gcggggcggg gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca      720

atcagagcgg cgcgctccga aagtttcctt ttatggcgag gcggcggcgg cggcggccct      780

ataaaaagcg aagcgcgcgg cgggcgggag tcgctgcgcg ctgccttcgc cccgtgcccc      840

gctccgccgc cgcctcgcgc cgcccgcccc ggctctgact gaccgcgtta ctcccacagg      900

tgagcgggcg ggacggccct tctcctccgg gctgtaatta gcgcttggtt taatgacggc      960

tcgtttcttt tctgtggctg cgtgaaagcc ttgaggggct ccgggagggc cctttgtgcg     1020

gggggagcgg ctcggggggt gcgtgcgtgt gtgtgtgcgt ggggagcgcc gcgtgcggct     1080

ccgcgctgcc cggcggctgt gagcgctgcg ggcgcggcgc ggggctttgt gcgctccgca     1140

gtgtgcgcga gaggagcgcg gccgggggcg gtgccacgcg gtgcgggggg ggctgcgagg     1200

ggaacaaagg ctgcgtgcgg ggtgtgtgcg tggggggggt gagcaggggg tgtgggcgcg     1260

gcggtcgggc tgtaaccccc ccctgcaccc ccctccccga gttgctgagc acggcccggc     1320

ttcgggtgcg gggctccgtg cggggcgtgg cgcggggctc gccgtgccgg gcggggggtg     1380

gcggcgggtg ggggtgccgg gcggggcggg gccgcctcgg gccggggagg gctcggggga     1440

ggggcgcggc ggcccccgga gcgccggcgg ctgtcgaggc gcggcgagcc gcagccattg     1500

ccttttatgg taatcgtgcg agagggcgca gggacttcct ttgtcccaaa tctgtgcgga     1560

gccgaaatct gggaggcgcc gccgcacccc ctctagcggg cgcggggcga agcggtgcgg     1620

cgccggcagg aaggaaatgg gcggggaggg ccttcgtgcg tcgccgcgcc gccgtcccct     1680

tctccctctc cagcctcggg gctgtccgcg gggggacggc tgccttcggg ggggacgggg     1740

cagggcgggg ttcggcttct ggcgtgtgac cggcggtcta gactctgcta accatgttca     1800

tgccttcttc tctttcctac agctcctggg caacgtgctg gttgttgtgc tgtctcatca     1860

ttttggcaaa gaattcaagc ttccagctag cgccaccatg gtcagcgttc caacagcctc     1920

accctcggca tccagcagct cctctcagtg ccggtccagc atgtgtcaat cacgctacct     1980

cctctttttg gccacccttg ccctcctaaa ccacctcagt ttggccaggg tcattccagt     2040

ctctggacct gccaggtgtc ttagccagtc ccgaaacctg ctgaagacca cagatgacat     2100

ggtgaagacg gccagagaaa aactgaaaca ttattcctgc actgctgaag acatcgatca     2160

tgaagacatc acacgggacc aaaccagcac attgaagacc tgtttaccac tggaactaca     2220

caagaacgag agttgcctgg ctactagaga gacttcttcc acaacaagag ggagctgcct     2280

gcccccacag aagacgtctt tgatgatgac cctgtgcctt ggtagcatct atgaggactt     2340

gaagatgtac cagacagagt tccaggccat caacgcagca cttcagaatc acaaccatca     2400

gcagatcatt ctagacaagg gcatgctggt ggccatcgat gagctgatgc agtctctgaa     2460

tcataatggc gagactctgc gccagaaacc tcctgtggga gaagcagacc cttacagagt     2520

gaaaatgaag ctctgcatcc tgcttcacgc cttcagcacc cgcgtcgtga ccatcaacag     2580

ggtgatgggc tatctgagct ccgccagaaa gagaaggagt ggctcaggag cccctgtgaa     2640

acagaccctg aactttgacc tcttgaagct tgctggggat gtggagtcta atcctggtcc     2700

aatgtgtcct cagaagctaa ccatctcctg gtttgccatc gttttgctgg tgtctccact     2760

catggccatg tgggagctgg agaaagacgt ttatgttgta gaggtggact ggactcccga     2820

tgcccctgga gaaacagtga acctcacctg tgacacgcct gaagaagatg acatcacctg     2880

gacctcagac cagagacatg gagtcatagg ctctggaaag accctgacca tcactgtcaa     2940

agagtttcta gatgctggcc agtacacctg ccacaaagga ggcgagactc tgagccactc     3000

acatctgctg ctccacaaga aggaaaatgg aatttggtcc actgaaattt taaaaaattt     3060

caaaaacaag actttcctga agtgtgaagc accaaattac tccggacggt tcacgtgctc     3120

atggctggtg caaagaaaca tggacttgaa gttcaacatc aagagcagta gcagttcccc     3180

tgactctcgg gcagtgacat gtggaatggc gtctctgtct gcagagaagg tcacactgga     3240

ccaaagggac tatgagaagt attcagtgtc ctgccaggag gatgtcacct gcccaactgc     3300

cgaggagacc ctgcccattg aactggcgtt ggaagcacgg cagcagaata aatatgagaa     3360

ctacagcacc agcttcttca tcagggacat catcaaacca gacccgccca agaacttgca     3420

gatgaagcct ttgaagaact cacaggtgga ggtcagctgg gagtaccctg actcctggag     3480

cactccccat tcctacttct ccctcaagtt ctttgttcga atccagcgca agaaagaaaa     3540

gatgaaggag acagaggagg ggtgtaacca gaaaggagcg ttcctcgtag agaagacatc     3600

taccgaagtc caatgcaaag gcgggaatgt ctgcgtgcaa gctcaggatc gctattacaa     3660

ttcctcatgc agcaagtggg catgtgttcc ctgcagggtc cgatcctgac aattgctgtg     3720

ccttctagtt gccagccatc tgttgtttgc ccctcccccg tgccttcctt gaccctggaa     3780

ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca ttgtctgagt     3840

aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga ggattgggaa     3900

gacaatagca ggcatgctgg ggatgcggtg ggctctatgg agctcgagag gaacccctag     3960

tgatggagtt ggccactccc tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa     4020

aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga gcgcgcagct     4080

gcagatctg                                                             4089


<210>  47
<211>  1830
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse CAG - wild-type IL-12B - F2A (not CpG modified) expression 
       sequence

<400>  47
gctagcgcca ccatggtcag cgttccaaca gcctcaccct cggcatccag cagctcctct       60

cagtgccggt ccagcatgtg tcaatcacgc tacctcctct ttttggccac ccttgccctc      120

ctaaaccacc tcagtttggc cagggtcatt ccagtctctg gacctgccag gtgtcttagc      180

cagtcccgaa acctgctgaa gaccacagat gacatggtga agacggccag agaaaaactg      240

aaacattatt cctgcactgc tgaagacatc gatcatgaag acatcacacg ggaccaaacc      300

agcacattga agacctgttt accactggaa ctacacaaga acgagagttg cctggctact      360

agagagactt cttccacaac aagagggagc tgcctgcccc cacagaagac gtctttgatg      420

atgaccctgt gccttggtag catctatgag gacttgaaga tgtaccagac agagttccag      480

gccatcaacg cagcacttca gaatcacaac catcagcaga tcattctaga caagggcatg      540

ctggtggcca tcgatgagct gatgcagtct ctgaatcata atggcgagac tctgcgccag      600

aaacctcctg tgggagaagc agacccttac agagtgaaaa tgaagctctg catcctgctt      660

cacgccttca gcacccgcgt cgtgaccatc aacagggtga tgggctatct gagctccgcc      720

agaaagagaa ggagtggctc aggagcccct gtgaaacaga ccctgaactt tgacctcttg      780

aagcttgctg gggatgtgga gtctaatcct ggtccaatgt gtcctcagaa gctaaccatc      840

tcctggtttg ccatcgtttt gctggtgtct ccactcatgg ccatgtggga gctggagaaa      900

gacgtttatg ttgtagaggt ggactggact cccgatgccc ctggagaaac agtgaacctc      960

acctgtgaca cgcctgaaga agatgacatc acctggacct cagaccagag acatggagtc     1020

ataggctctg gaaagaccct gaccatcact gtcaaagagt ttctagatgc tggccagtac     1080

acctgccaca aaggaggcga gactctgagc cactcacatc tgctgctcca caagaaggaa     1140

aatggaattt ggtccactga aattttaaaa aatttcaaaa acaagacttt cctgaagtgt     1200

gaagcaccaa attactccgg acggttcacg tgctcatggc tggtgcaaag aaacatggac     1260

ttgaagttca acatcaagag cagtagcagt tcccctgact ctcgggcagt gacatgtgga     1320

atggcgtctc tgtctgcaga gaaggtcaca ctggaccaaa gggactatga gaagtattca     1380

gtgtcctgcc aggaggatgt cacctgccca actgccgagg agaccctgcc cattgaactg     1440

gcgttggaag cacggcagca gaataaatat gagaactaca gcaccagctt cttcatcagg     1500

gacatcatca aaccagaccc gcccaagaac ttgcagatga agcctttgaa gaactcacag     1560

gtggaggtca gctgggagta ccctgactcc tggagcactc cccattccta cttctccctc     1620

aagttctttg ttcgaatcca gcgcaagaaa gaaaagatga aggagacaga ggaggggtgt     1680

aaccagaaag gagcgttcct cgtagagaag acatctaccg aagtccaatg caaaggcggg     1740

aatgtctgcg tgcaagctca ggatcgctat tacaattcct catgcagcaa gtgggcatgt     1800

gttccctgca gggtccgatc ctgacaattg                                      1830


<210>  48
<211>  4017
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human CAG - modified IL-12A/IL-12B - F2A (CpG modified) construct

<400>  48
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tagtattaaa cgcgtgtcga cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggg tcgaggtgag      540

ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa ttttgtattt      600

atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg cgcgcgccag      660

gcggggcggg gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca      720

atcagagcgg cgcgctccga aagtttcctt ttatggcgag gcggcggcgg cggcggccct      780

ataaaaagcg aagcgcgcgg cgggcgggag tcgctgcgcg ctgccttcgc cccgtgcccc      840

gctccgccgc cgcctcgcgc cgcccgcccc ggctctgact gaccgcgtta ctcccacagg      900

tgagcgggcg ggacggccct tctcctccgg gctgtaatta gcgcttggtt taatgacggc      960

tcgtttcttt tctgtggctg cgtgaaagcc ttgaggggct ccgggagggc cctttgtgcg     1020

gggggagcgg ctcggggggt gcgtgcgtgt gtgtgtgcgt ggggagcgcc gcgtgcggct     1080

ccgcgctgcc cggcggctgt gagcgctgcg ggcgcggcgc ggggctttgt gcgctccgca     1140

gtgtgcgcga gaggagcgcg gccgggggcg gtgccacgcg gtgcgggggg ggctgcgagg     1200

ggaacaaagg ctgcgtgcgg ggtgtgtgcg tggggggggt gagcaggggg tgtgggcgcg     1260

gcggtcgggc tgtaaccccc ccctgcaccc ccctccccga gttgctgagc acggcccggc     1320

ttcgggtgcg gggctccgtg cggggcgtgg cgcggggctc gccgtgccgg gcggggggtg     1380

gcggcgggtg ggggtgccgg gcggggcggg gccgcctcgg gccggggagg gctcggggga     1440

ggggcgcggc ggcccccgga gcgccggcgg ctgtcgaggc gcggcgagcc gcagccattg     1500

ccttttatgg taatcgtgcg agagggcgca gggacttcct ttgtcccaaa tctgtgcgga     1560

gccgaaatct gggaggcgcc gccgcacccc ctctagcggg cgcggggcga agcggtgcgg     1620

cgccggcagg aaggaaatgg gcggggaggg ccttcgtgcg tcgccgcgcc gccgtcccct     1680

tctccctctc cagcctcggg gctgtccgcg gggggacggc tgccttcggg ggggacgggg     1740

cagggcgggg ttcggcttct ggcgtgtgac cggcggtcta gactctgcta accatgttca     1800

tgccttcttc tctttcctac agctcctggg caacgtgctg gttgttgtgc tgtctcatca     1860

ttttggcaaa gaattcaagc ttccagctag cgccaccatg tgtccagcta ggagcctcct     1920

ccttgtggct accctggtcc tcctggacca cctcagtttg gccagaaacc tccctgtggc     1980

cactccagac ccaggaatgt tcccatgcct tcaccactcc caaaacctgc tgagggcagt     2040

cagcaacatg ctccagaagg ccagacaaac tctagaattt tacccttgca cttctgaaga     2100

gattgatcat gaagatatca caaaagataa aaccagcaca gtggaggcct gtttaccatt     2160

ggaattaacc aagaatgaga gttgcctaaa ttccagagag acctctttca taactaatgg     2220

gagttgcctg gcctccagaa agacctcttt tatgatggcc ctgtgcctta gtagtattta     2280

tgaagacttg aagatgtacc aggtggagtt caagaccatg aatgcaaagc ttctgatgga     2340

tcctaagagg cagatctttc tagatcaaaa catgctggca gttattgatg agctgatgca     2400

ggccctgaat ttcaacagtg agactgtgcc acaaaaatcc tcccttgaag aacctgattt     2460

ttataaaact aaaatcaagc tctgcatact tcttcatgct ttccggatta gggcagtgac     2520

tattgataga gtgatgagct atctgaatgc ttccagaaag agaaggagtg gctcaggagc     2580

ccctgtgaaa cagaccctga actttgacct cttgaagctt gctggggatg tggagtctaa     2640

tcctggtcca atgtgtcacc agcagttggt catctcttgg ttttccctgg tttttctggc     2700

atctcccctt gtggccatat gggaactgaa gaaagatgtt tatgtggtag aattggattg     2760

gtatcctgat gcccctggag aaatggtggt cctcacctgt gacacccctg aagaagatgg     2820

tatcacctgg accttggacc agagcagtga ggtcttaggc tctggcaaaa ccctgaccat     2880

ccaagtcaaa gagtttggag atgctggcca gtacacctgt cacaaaggag gggaggttct     2940

aagccattcc ctcctgctgc ttcacaaaaa ggaagatgga atttggtcca ctgatatttt     3000

aaaggaccag aaagaaccca aaaataagac ctttctaaga tgtgaggcca agaattattc     3060

tggaaggttc acctgctggt ggctgactac aatcagtact gatttgacat tcagtgtcaa     3120

aagcagcaga ggctcttctg acccccaagg ggtgacatgt ggagctgcta cactctctgc     3180

agagagagtc agaggggaca acaaggagta tgagtactca gtggagtgcc aggaggacag     3240

tgcctgccca gctgctgagg agagtctgcc cattgaggtg atggtggatg cagttcacaa     3300

gctcaagtat gaaaactaca ccagcagctt cttcatcagg gacatcatca aacctgaccc     3360

acccaagaac ttgcagctga agccattaaa gaattctagg caggtggagg tcagctggga     3420

gtaccctgac acctggagta ctccacattc ctacttctcc ctgacattct gtgttcaagt     3480

ccagggcaag agcaagagag aaaagaaaga tagagtcttc actgacaaga cctcagccac     3540

agtcatctgc aggaaaaatg ccagcatttc agtgagggcc caggacagat actatagctc     3600

atcttggtca gaatgggcat ctgtgccctg cagttgacaa ttgctgtgcc ttctagttgc     3660

cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc     3720

actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct     3780

attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg     3840

catgctgggg atgcggtggg ctctatggag ctcgagagga acccctagtg atggagttgg     3900

ccactccctc tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac     3960

gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc gcgcagctgc agatctg        4017


<210>  49
<211>  1758
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human CAG - modified IL-12A/IL-12B - F2A (CpG modified) 
       expression sequence

<400>  49
gctagcgcca ccatgtgtcc agctaggagc ctcctccttg tggctaccct ggtcctcctg       60

gaccacctca gtttggccag aaacctccct gtggccactc cagacccagg aatgttccca      120

tgccttcacc actcccaaaa cctgctgagg gcagtcagca acatgctcca gaaggccaga      180

caaactctag aattttaccc ttgcacttct gaagagattg atcatgaaga tatcacaaaa      240

gataaaacca gcacagtgga ggcctgttta ccattggaat taaccaagaa tgagagttgc      300

ctaaattcca gagagacctc tttcataact aatgggagtt gcctggcctc cagaaagacc      360

tcttttatga tggccctgtg ccttagtagt atttatgaag acttgaagat gtaccaggtg      420

gagttcaaga ccatgaatgc aaagcttctg atggatccta agaggcagat ctttctagat      480

caaaacatgc tggcagttat tgatgagctg atgcaggccc tgaatttcaa cagtgagact      540

gtgccacaaa aatcctccct tgaagaacct gatttttata aaactaaaat caagctctgc      600

atacttcttc atgctttccg gattagggca gtgactattg atagagtgat gagctatctg      660

aatgcttcca gaaagagaag gagtggctca ggagcccctg tgaaacagac cctgaacttt      720

gacctcttga agcttgctgg ggatgtggag tctaatcctg gtccaatgtg tcaccagcag      780

ttggtcatct cttggttttc cctggttttt ctggcatctc cccttgtggc catatgggaa      840

ctgaagaaag atgtttatgt ggtagaattg gattggtatc ctgatgcccc tggagaaatg      900

gtggtcctca cctgtgacac ccctgaagaa gatggtatca cctggacctt ggaccagagc      960

agtgaggtct taggctctgg caaaaccctg accatccaag tcaaagagtt tggagatgct     1020

ggccagtaca cctgtcacaa aggaggggag gttctaagcc attccctcct gctgcttcac     1080

aaaaaggaag atggaatttg gtccactgat attttaaagg accagaaaga acccaaaaat     1140

aagacctttc taagatgtga ggccaagaat tattctggaa ggttcacctg ctggtggctg     1200

actacaatca gtactgattt gacattcagt gtcaaaagca gcagaggctc ttctgacccc     1260

caaggggtga catgtggagc tgctacactc tctgcagaga gagtcagagg ggacaacaag     1320

gagtatgagt actcagtgga gtgccaggag gacagtgcct gcccagctgc tgaggagagt     1380

ctgcccattg aggtgatggt ggatgcagtt cacaagctca agtatgaaaa ctacaccagc     1440

agcttcttca tcagggacat catcaaacct gacccaccca agaacttgca gctgaagcca     1500

ttaaagaatt ctaggcaggt ggaggtcagc tgggagtacc ctgacacctg gagtactcca     1560

cattcctact tctccctgac attctgtgtt caagtccagg gcaagagcaa gagagaaaag     1620

aaagatagag tcttcactga caagacctca gccacagtca tctgcaggaa aaatgccagc     1680

atttcagtga gggcccagga cagatactat agctcatctt ggtcagaatg ggcatctgtg     1740

ccctgcagtt gacaattg                                                   1758


<210>  50
<211>  4017
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human CAG - modified IL-12A/IL-12B - F2A (CpG modified) construct

<400>  50
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tagtattaaa cgcgtgtcga cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggg tcgaggtgag      540

ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa ttttgtattt      600

atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg cgcgcgccag      660

gcggggcggg gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca      720

atcagagcgg cgcgctccga aagtttcctt ttatggcgag gcggcggcgg cggcggccct      780

ataaaaagcg aagcgcgcgg cgggcgggag tcgctgcgcg ctgccttcgc cccgtgcccc      840

gctccgccgc cgcctcgcgc cgcccgcccc ggctctgact gaccgcgtta ctcccacagg      900

tgagcgggcg ggacggccct tctcctccgg gctgtaatta gcgcttggtt taatgacggc      960

tcgtttcttt tctgtggctg cgtgaaagcc ttgaggggct ccgggagggc cctttgtgcg     1020

gggggagcgg ctcggggggt gcgtgcgtgt gtgtgtgcgt ggggagcgcc gcgtgcggct     1080

ccgcgctgcc cggcggctgt gagcgctgcg ggcgcggcgc ggggctttgt gcgctccgca     1140

gtgtgcgcga gaggagcgcg gccgggggcg gtgccacgcg gtgcgggggg ggctgcgagg     1200

ggaacaaagg ctgcgtgcgg ggtgtgtgcg tggggggggt gagcaggggg tgtgggcgcg     1260

gcggtcgggc tgtaaccccc ccctgcaccc ccctccccga gttgctgagc acggcccggc     1320

ttcgggtgcg gggctccgtg cggggcgtgg cgcggggctc gccgtgccgg gcggggggtg     1380

gcggcgggtg ggggtgccgg gcggggcggg gccgcctcgg gccggggagg gctcggggga     1440

ggggcgcggc ggcccccgga gcgccggcgg ctgtcgaggc gcggcgagcc gcagccattg     1500

ccttttatgg taatcgtgcg agagggcgca gggacttcct ttgtcccaaa tctgtgcgga     1560

gccgaaatct gggaggcgcc gccgcacccc ctctagcggg cgcggggcga agcggtgcgg     1620

cgccggcagg aaggaaatgg gcggggaggg ccttcgtgcg tcgccgcgcc gccgtcccct     1680

tctccctctc cagcctcggg gctgtccgcg gggggacggc tgccttcggg ggggacgggg     1740

cagggcgggg ttcggcttct ggcgtgtgac cggcggtcta gactctgcta accatgttca     1800

tgccttcttc tctttcctac agctcctggg caacgtgctg gttgttgtgc tgtctcatca     1860

ttttggcaaa gaattcaagc ttccagctag cgccaccatg tgtccagcgc gcagcctcct     1920

ccttgtggct accctggtcc tcctggacca cctcagtttg gccagaaacc tccctgtggc     1980

cactccagac ccaggaatgt tcccatgcct tcaccactcc caaaacctgc tgagggctgt     2040

cagcaacatg ctccagaagg ccagacaaac tctagaattt tacccttgca cttctgaaga     2100

gattgatcat gaagatatca caaaagataa aaccagcaca gtggaggcct gtttaccatt     2160

ggaattaacc aagaatgaga gttgcctaaa ttccagagag acctctttca taactaatgg     2220

gagttgcctg gcctccagaa agacctcttt tatgatggcc ctgtgcctta gtagtattta     2280

tgaagacttg aagatgtacc aggtggagtt caagaccatg aatgcaaagc ttctgatgga     2340

tcctaagagg cagatctttc tagatcaaaa catgctggca gttattgatg agctgatgca     2400

ggccctgaat ttcaacagtg agactgtgcc acaaaaatcc tcccttgaag aacctgattt     2460

ttataaaact aaaatcaagc tctgcatact tcttcatgct ttccggattc gcgcagtgac     2520

tattgataga gtgatgagct atctgaatgc ttccagaaag agaaggagtg gctcaggagc     2580

ccctgtgaaa cagaccctga actttgacct cttgaagctt gctggggatg tggagtctaa     2640

tcctggtcca atgtgtcacc agcagttggt catctcttgg ttttccctgg tttttctggc     2700

atctcccctt gtggccatat gggaactgaa gaaagatgtt tatgtggtag aattggattg     2760

gtatcctgat gcccctggag aaatggtggt cctcacctgt gacacccctg aagaagatgg     2820

tatcacctgg accttggacc agagcagtga ggtcttaggc tctggcaaaa ccctgaccat     2880

ccaagtcaaa gagtttggag atgctggcca gtacacctgt cacaaaggag gggaggttct     2940

aagccattcc ctcctgctgc ttcacaaaaa ggaagatgga atttggtcca ctgatatttt     3000

aaaggaccag aaagaaccca aaaataagac ctttctaaga tgtgaggcca agaattattc     3060

tggaaggttc acctgctggt ggctgactac aatcagtact gatttgacat tcagtgtcaa     3120

aagcagcaga ggctcttctg acccccaagg ggtgacatgc ggagctgcta cactctctgc     3180

agagagagtc agaggggaca acaaggagta tgagtactca gtggagtgcc aggaggacag     3240

tgcctgccca gctgctgagg agagtctgcc cattgaggtg atggtggatg cggttcacaa     3300

gctcaagtat gaaaactaca ccagcagctt cttcatcagg gacatcatca aacctgaccc     3360

acccaagaac ttgcagctga agccattaaa gaattctagg caggtggagg tcagctggga     3420

gtaccctgac acctggagta ctccacattc ctacttctcc ctgacattct gtgttcaagt     3480

ccagggcaag agcaagagag aaaagaaaga tagagtcttc actgacaaga cctcagccac     3540

agtcatctgc cgcaaaaatg ccagcatttc agtgcgggcc caggaccgct actatagctc     3600

atcttggtca gaatgggcat ctgtgccctg cagttgacaa ttgctgtgcc ttctagttgc     3660

cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc     3720

actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct     3780

attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg     3840

catgctgggg atgcggtggg ctctatggag ctcgagagga acccctagtg atggagttgg     3900

ccactccctc tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac     3960

gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc gcgcagctgc agatctg        4017


<210>  51
<211>  1758
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human CAG - modified IL-12A/IL-12B - F2A (CpG modified) 
       expression sequence

<400>  51
gctagcgcca ccatgtgtcc agcgcgcagc ctcctccttg tggctaccct ggtcctcctg       60

gaccacctca gtttggccag aaacctccct gtggccactc cagacccagg aatgttccca      120

tgccttcacc actcccaaaa cctgctgagg gctgtcagca acatgctcca gaaggccaga      180

caaactctag aattttaccc ttgcacttct gaagagattg atcatgaaga tatcacaaaa      240

gataaaacca gcacagtgga ggcctgttta ccattggaat taaccaagaa tgagagttgc      300

ctaaattcca gagagacctc tttcataact aatgggagtt gcctggcctc cagaaagacc      360

tcttttatga tggccctgtg ccttagtagt atttatgaag acttgaagat gtaccaggtg      420

gagttcaaga ccatgaatgc aaagcttctg atggatccta agaggcagat ctttctagat      480

caaaacatgc tggcagttat tgatgagctg atgcaggccc tgaatttcaa cagtgagact      540

gtgccacaaa aatcctccct tgaagaacct gatttttata aaactaaaat caagctctgc      600

atacttcttc atgctttccg gattcgcgca gtgactattg atagagtgat gagctatctg      660

aatgcttcca gaaagagaag gagtggctca ggagcccctg tgaaacagac cctgaacttt      720

gacctcttga agcttgctgg ggatgtggag tctaatcctg gtccaatgtg tcaccagcag      780

ttggtcatct cttggttttc cctggttttt ctggcatctc cccttgtggc catatgggaa      840

ctgaagaaag atgtttatgt ggtagaattg gattggtatc ctgatgcccc tggagaaatg      900

gtggtcctca cctgtgacac ccctgaagaa gatggtatca cctggacctt ggaccagagc      960

agtgaggtct taggctctgg caaaaccctg accatccaag tcaaagagtt tggagatgct     1020

ggccagtaca cctgtcacaa aggaggggag gttctaagcc attccctcct gctgcttcac     1080

aaaaaggaag atggaatttg gtccactgat attttaaagg accagaaaga acccaaaaat     1140

aagacctttc taagatgtga ggccaagaat tattctggaa ggttcacctg ctggtggctg     1200

actacaatca gtactgattt gacattcagt gtcaaaagca gcagaggctc ttctgacccc     1260

caaggggtga catgcggagc tgctacactc tctgcagaga gagtcagagg ggacaacaag     1320

gagtatgagt actcagtgga gtgccaggag gacagtgcct gcccagctgc tgaggagagt     1380

ctgcccattg aggtgatggt ggatgcggtt cacaagctca agtatgaaaa ctacaccagc     1440

agcttcttca tcagggacat catcaaacct gacccaccca agaacttgca gctgaagcca     1500

ttaaagaatt ctaggcaggt ggaggtcagc tgggagtacc ctgacacctg gagtactcca     1560

cattcctact tctccctgac attctgtgtt caagtccagg gcaagagcaa gagagaaaag     1620

aaagatagag tcttcactga caagacctca gccacagtca tctgccgcaa aaatgccagc     1680

atttcagtgc gggcccagga ccgctactat agctcatctt ggtcagaatg ggcatctgtg     1740

ccctgcagtt gacaattg                                                   1758


<210>  52
<211>  4509
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human CAG - modified IL-12A/IL-12B - IRES (CpG modified) 
       construct

<400>  52
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tagtattaaa cgcgtgtcga cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggg tcgaggtgag      540

ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa ttttgtattt      600

atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg cgcgcgccag      660

gcggggcggg gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca      720

atcagagcgg cgcgctccga aagtttcctt ttatggcgag gcggcggcgg cggcggccct      780

ataaaaagcg aagcgcgcgg cgggcgggag tcgctgcgcg ctgccttcgc cccgtgcccc      840

gctccgccgc cgcctcgcgc cgcccgcccc ggctctgact gaccgcgtta ctcccacagg      900

tgagcgggcg ggacggccct tctcctccgg gctgtaatta gcgcttggtt taatgacggc      960

tcgtttcttt tctgtggctg cgtgaaagcc ttgaggggct ccgggagggc cctttgtgcg     1020

gggggagcgg ctcggggggt gcgtgcgtgt gtgtgtgcgt ggggagcgcc gcgtgcggct     1080

ccgcgctgcc cggcggctgt gagcgctgcg ggcgcggcgc ggggctttgt gcgctccgca     1140

gtgtgcgcga gaggagcgcg gccgggggcg gtgccacgcg gtgcgggggg ggctgcgagg     1200

ggaacaaagg ctgcgtgcgg ggtgtgtgcg tggggggggt gagcaggggg tgtgggcgcg     1260

gcggtcgggc tgtaaccccc ccctgcaccc ccctccccga gttgctgagc acggcccggc     1320

ttcgggtgcg gggctccgtg cggggcgtgg cgcggggctc gccgtgccgg gcggggggtg     1380

gcggcgggtg ggggtgccgg gcggggcggg gccgcctcgg gccggggagg gctcggggga     1440

ggggcgcggc ggcccccgga gcgccggcgg ctgtcgaggc gcggcgagcc gcagccattg     1500

ccttttatgg taatcgtgcg agagggcgca gggacttcct ttgtcccaaa tctgtgcgga     1560

gccgaaatct gggaggcgcc gccgcacccc ctctagcggg cgcggggcga agcggtgcgg     1620

cgccggcagg aaggaaatgg gcggggaggg ccttcgtgcg tcgccgcgcc gccgtcccct     1680

tctccctctc cagcctcggg gctgtccgcg gggggacggc tgccttcggg ggggacgggg     1740

cagggcgggg ttcggcttct ggcgtgtgac cggcggtcta gactctgcta accatgttca     1800

tgccttcttc tctttcctac agctcctggg caacgtgctg gttgttgtgc tgtctcatca     1860

ttttggcaaa gaattcaagc ttccagctag cgccaccatg tgtccagcta ggagcctcct     1920

ccttgtggct accctggtcc tcctggacca cctcagtttg gccagaaacc tccctgtggc     1980

cactccagac ccaggaatgt tcccatgcct tcaccactcc caaaacctgc tgagggcagt     2040

cagcaacatg ctccagaagg ccagacaaac tctagaattt tacccttgca cttctgaaga     2100

gattgatcat gaagatatca caaaagataa aaccagcaca gtggaggcct gtttaccatt     2160

ggaattaacc aagaatgaga gttgcctaaa ttccagagag acctctttca taactaatgg     2220

gagttgcctg gcctccagaa agacctcttt tatgatggcc ctgtgcctta gtagtattta     2280

tgaagacttg aagatgtacc aggtggagtt caagaccatg aatgcaaagc ttctgatgga     2340

tcctaagagg cagatctttc tagatcaaaa catgctggca gttattgatg agctgatgca     2400

ggccctgaat ttcaacagtg agactgtgcc acaaaaatcc tcccttgaag aacctgattt     2460

ttataaaact aaaatcaagc tctgcatact tcttcatgct ttccggatta gggcagtgac     2520

tattgataga gtgatgagct atctgaatgc ttcctgagcc cctctccctc ccccccccct     2580

aacgttactg gccgaagccg cttggaataa ggccggtgtg cgtttgtcta tatgttattt     2640

tccaccatat tgccgtcttt tggcaatgtg agggcccgga aacctggccc tgtcttcttg     2700

acgagcattc ctaggggtct ttcccctctc gccaaaggaa tgcaaggtct gttgaatgtc     2760

gtgaaggaag cagttcctct ggaagcttct tgaagacaaa caacgtctgt agcgaccctt     2820

tgcaggcagc ggaacccccc acctggcgac aggtgcctct gcggccaaaa gccacgtgta     2880

taagatacac ctgcaaaggc ggcacaaccc cagtgccacg ttgtgagttg gatagttgtg     2940

gaaagagtca aatggctctc ctcaagcgta ttcaacaagg ggctgaagga tgcccagaag     3000

gtaccccatt gtatgggatc tgatctgggg cctcggtaca catgctttac atgtgtttag     3060

tcgaggttaa aaaaacgtct aggccccccg aaccacgggg acgtggtttt cctttgaaaa     3120

acacgatgat aatatggcca caatgtgtca ccagcagttg gtcatctctt ggttttccct     3180

ggtttttctg gcatctcccc ttgtggccat atgggaactg aagaaagatg tttatgtggt     3240

agaattggat tggtatcctg atgcccctgg agaaatggtg gtcctcacct gtgacacccc     3300

tgaagaagat ggtatcacct ggaccttgga ccagagcagt gaggtcttag gctctggcaa     3360

aaccctgacc atccaagtca aagagtttgg agatgctggc cagtacacct gtcacaaagg     3420

aggggaggtt ctaagccatt ccctcctgct gcttcacaaa aaggaagatg gaatttggtc     3480

cactgatatt ttaaaggacc agaaagaacc caaaaataag acctttctaa gatgtgaggc     3540

caagaattat tctggaaggt tcacctgctg gtggctgact acaatcagta ctgatttgac     3600

attcagtgtc aaaagcagca gaggctcttc tgacccccaa ggggtgacat gtggagctgc     3660

tacactctct gcagagagag tcagagggga caacaaggag tatgagtact cagtggagtg     3720

ccaggaggac agtgcctgcc cagctgctga ggagagtctg cccattgagg tgatggtgga     3780

tgcagttcac aagctcaagt atgaaaacta caccagcagc ttcttcatca gggacatcat     3840

caaacctgac ccacccaaga acttgcagct gaagccatta aagaattcta ggcaggtgga     3900

ggtcagctgg gagtaccctg acacctggag tactccacat tcctacttct ccctgacatt     3960

ctgtgttcaa gtccagggca agagcaagag agaaaagaaa gatagagtct tcactgacaa     4020

gacctcagcc acagtcatct gcaggaaaaa tgccagcatt tcagtgaggg cccaggacag     4080

atactatagc tcatcttggt cagaatgggc atctgtgccc tgcagttgac aattgctgtg     4140

ccttctagtt gccagccatc tgttgtttgc ccctcccccg tgccttcctt gaccctggaa     4200

ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca ttgtctgagt     4260

aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga ggattgggaa     4320

gacaatagca ggcatgctgg ggatgcggtg ggctctatgg agctcgagag gaacccctag     4380

tgatggagtt ggccactccc tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa     4440

aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga gcgcgcagct     4500

gcagatctg                                                             4509


<210>  53
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human CAG - modified IL-12A/IL-12B - IRES (CpG modified) 
       expression sequence

<400>  53
gctagcgcca ccatgtgtcc agctaggagc ctcctccttg tggctaccct ggtcctcctg       60

gaccacctca gtttggccag aaacctccct gtggccactc cagacccagg aatgttccca      120

tgccttcacc actcccaaaa cctgctgagg gcagtcagca acatgctcca gaaggccaga      180

caaactctag aattttaccc ttgcacttct gaagagattg atcatgaaga tatcacaaaa      240

gataaaacca gcacagtgga ggcctgttta ccattggaat taaccaagaa tgagagttgc      300

ctaaattcca gagagacctc tttcataact aatgggagtt gcctggcctc cagaaagacc      360

tcttttatga tggccctgtg ccttagtagt atttatgaag acttgaagat gtaccaggtg      420

gagttcaaga ccatgaatgc aaagcttctg atggatccta agaggcagat ctttctagat      480

caaaacatgc tggcagttat tgatgagctg atgcaggccc tgaatttcaa cagtgagact      540

gtgccacaaa aatcctccct tgaagaacct gatttttata aaactaaaat caagctctgc      600

atacttcttc atgctttccg gattagggca gtgactattg atagagtgat gagctatctg      660

aatgcttcct gagcccctct ccctcccccc cccctaacgt tactggccga agccgcttgg      720

aataaggccg gtgtgcgttt gtctatatgt tattttccac catattgccg tcttttggca      780

atgtgagggc ccggaaacct ggccctgtct tcttgacgag cattcctagg ggtctttccc      840

ctctcgccaa aggaatgcaa ggtctgttga atgtcgtgaa ggaagcagtt cctctggaag      900

cttcttgaag acaaacaacg tctgtagcga ccctttgcag gcagcggaac cccccacctg      960

gcgacaggtg cctctgcggc caaaagccac gtgtataaga tacacctgca aaggcggcac     1020

aaccccagtg ccacgttgtg agttggatag ttgtggaaag agtcaaatgg ctctcctcaa     1080

gcgtattcaa caaggggctg aaggatgccc agaaggtacc ccattgtatg ggatctgatc     1140

tggggcctcg gtacacatgc tttacatgtg tttagtcgag gttaaaaaaa cgtctaggcc     1200

ccccgaacca cggggacgtg gttttccttt gaaaaacacg atgataatat ggccacaatg     1260

tgtcaccagc agttggtcat ctcttggttt tccctggttt ttctggcatc tccccttgtg     1320

gccatatggg aactgaagaa agatgtttat gtggtagaat tggattggta tcctgatgcc     1380

cctggagaaa tggtggtcct cacctgtgac acccctgaag aagatggtat cacctggacc     1440

ttggaccaga gcagtgaggt cttaggctct ggcaaaaccc tgaccatcca agtcaaagag     1500

tttggagatg ctggccagta cacctgtcac aaaggagggg aggttctaag ccattccctc     1560

ctgctgcttc acaaaaagga agatggaatt tggtccactg atattttaaa ggaccagaaa     1620

gaacccaaaa ataagacctt tctaagatgt gaggccaaga attattctgg aaggttcacc     1680

tgctggtggc tgactacaat cagtactgat ttgacattca gtgtcaaaag cagcagaggc     1740

tcttctgacc cccaaggggt gacatgtgga gctgctacac tctctgcaga gagagtcaga     1800

ggggacaaca aggagtatga gtactcagtg gagtgccagg aggacagtgc ctgcccagct     1860

gctgaggaga gtctgcccat tgaggtgatg gtggatgcag ttcacaagct caagtatgaa     1920

aactacacca gcagcttctt catcagggac atcatcaaac ctgacccacc caagaacttg     1980

cagctgaagc cattaaagaa ttctaggcag gtggaggtca gctgggagta ccctgacacc     2040

tggagtactc cacattccta cttctccctg acattctgtg ttcaagtcca gggcaagagc     2100

aagagagaaa agaaagatag agtcttcact gacaagacct cagccacagt catctgcagg     2160

aaaaatgcca gcatttcagt gagggcccag gacagatact atagctcatc ttggtcagaa     2220

tgggcatctg tgccctgcag ttgacaattg                                      2250


<210>  54
<211>  4509
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human CAG - modified IL-12A/IL-12B - IRES (CpG modified) 
       construct

<400>  54
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tagtattaaa cgcgtgtcga cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggg tcgaggtgag      540

ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa ttttgtattt      600

atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg cgcgcgccag      660

gcggggcggg gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca      720

atcagagcgg cgcgctccga aagtttcctt ttatggcgag gcggcggcgg cggcggccct      780

ataaaaagcg aagcgcgcgg cgggcgggag tcgctgcgcg ctgccttcgc cccgtgcccc      840

gctccgccgc cgcctcgcgc cgcccgcccc ggctctgact gaccgcgtta ctcccacagg      900

tgagcgggcg ggacggccct tctcctccgg gctgtaatta gcgcttggtt taatgacggc      960

tcgtttcttt tctgtggctg cgtgaaagcc ttgaggggct ccgggagggc cctttgtgcg     1020

gggggagcgg ctcggggggt gcgtgcgtgt gtgtgtgcgt ggggagcgcc gcgtgcggct     1080

ccgcgctgcc cggcggctgt gagcgctgcg ggcgcggcgc ggggctttgt gcgctccgca     1140

gtgtgcgcga gaggagcgcg gccgggggcg gtgccacgcg gtgcgggggg ggctgcgagg     1200

ggaacaaagg ctgcgtgcgg ggtgtgtgcg tggggggggt gagcaggggg tgtgggcgcg     1260

gcggtcgggc tgtaaccccc ccctgcaccc ccctccccga gttgctgagc acggcccggc     1320

ttcgggtgcg gggctccgtg cggggcgtgg cgcggggctc gccgtgccgg gcggggggtg     1380

gcggcgggtg ggggtgccgg gcggggcggg gccgcctcgg gccggggagg gctcggggga     1440

ggggcgcggc ggcccccgga gcgccggcgg ctgtcgaggc gcggcgagcc gcagccattg     1500

ccttttatgg taatcgtgcg agagggcgca gggacttcct ttgtcccaaa tctgtgcgga     1560

gccgaaatct gggaggcgcc gccgcacccc ctctagcggg cgcggggcga agcggtgcgg     1620

cgccggcagg aaggaaatgg gcggggaggg ccttcgtgcg tcgccgcgcc gccgtcccct     1680

tctccctctc cagcctcggg gctgtccgcg gggggacggc tgccttcggg ggggacgggg     1740

cagggcgggg ttcggcttct ggcgtgtgac cggcggtcta gactctgcta accatgttca     1800

tgccttcttc tctttcctac agctcctggg caacgtgctg gttgttgtgc tgtctcatca     1860

ttttggcaaa gaattcaagc ttccagctag cgccaccatg tgtccagcgc gcagcctcct     1920

ccttgtggct accctggtcc tcctggacca cctcagtttg gccagaaacc tccctgtggc     1980

cactccagac ccaggaatgt tcccatgcct tcaccactcc caaaacctgc tgagggctgt     2040

cagcaacatg ctccagaagg ccagacaaac tctagaattt tacccttgca cttctgaaga     2100

gattgatcat gaagatatca caaaagataa aaccagcaca gtggaggcct gtttaccatt     2160

ggaattaacc aagaatgaga gttgcctaaa ttccagagag acctctttca taactaatgg     2220

gagttgcctg gcctccagaa agacctcttt tatgatggcc ctgtgcctta gtagtattta     2280

tgaagacttg aagatgtacc aggtggagtt caagaccatg aatgcaaagc ttctgatgga     2340

tcctaagagg cagatctttc tagatcaaaa catgctggca gttattgatg agctgatgca     2400

ggccctgaat ttcaacagtg agactgtgcc acaaaaatcc tcccttgaag aacctgattt     2460

ttataaaact aaaatcaagc tctgcatact tcttcatgct ttccggattc gcgcagtgac     2520

tattgataga gtgatgagct atctgaatgc ttcctgagcc cctctccctc ccccccccct     2580

aacgttactg gccgaagccg cttggaataa ggccggtgtg cgtttgtcta tatgttattt     2640

tccaccatat tgccgtcttt tggcaatgtg agggcccgga aacctggccc tgtcttcttg     2700

acgagcattc ctaggggtct ttcccctctc gccaaaggaa tgcaaggtct gttgaatgtc     2760

gtgaaggaag cagttcctct ggaagcttct tgaagacaaa caacgtctgt agcgaccctt     2820

tgcaggcagc ggaacccccc acctggcgac aggtgcctct gcggccaaaa gccacgtgta     2880

taagatacac ctgcaaaggc ggcacaaccc cagtgccacg ttgtgagttg gatagttgtg     2940

gaaagagtca aatggctctc ctcaagcgta ttcaacaagg ggctgaagga tgcccagaag     3000

gtaccccatt gtatgggatc tgatctgggg cctcggtaca catgctttac atgtgtttag     3060

tcgaggttaa aaaaacgtct aggccccccg aaccacgggg acgtggtttt cctttgaaaa     3120

acacgatgat aatatggcca caatgtgtca ccagcagttg gtcatctctt ggttttccct     3180

ggtttttctg gcatctcccc ttgtggccat atgggaactg aagaaagatg tttatgtggt     3240

agaattggat tggtatcctg atgcccctgg agaaatggtg gtcctcacct gtgacacccc     3300

tgaagaagat ggtatcacct ggaccttgga ccagagcagt gaggtcttag gctctggcaa     3360

aaccctgacc atccaagtca aagagtttgg agatgctggc cagtacacct gtcacaaagg     3420

aggggaggtt ctaagccatt ccctcctgct gcttcacaaa aaggaagatg gaatttggtc     3480

cactgatatt ttaaaggacc agaaagaacc caaaaataag acctttctaa gatgtgaggc     3540

caagaattat tctggaaggt tcacctgctg gtggctgact acaatcagta ctgatttgac     3600

attcagtgtc aaaagcagca gaggctcttc tgacccccaa ggggtgacat gcggagctgc     3660

tacactctct gcagagagag tcagagggga caacaaggag tatgagtact cagtggagtg     3720

ccaggaggac agtgcctgcc cagctgctga ggagagtctg cccattgagg tgatggtgga     3780

tgcggttcac aagctcaagt atgaaaacta caccagcagc ttcttcatca gggacatcat     3840

caaacctgac ccacccaaga acttgcagct gaagccatta aagaattcta ggcaggtgga     3900

ggtcagctgg gagtaccctg acacctggag tactccacat tcctacttct ccctgacatt     3960

ctgtgttcaa gtccagggca agagcaagag agaaaagaaa gatagagtct tcactgacaa     4020

gacctcagcc acagtcatct gccgcaaaaa tgccagcatt tcagtgcggg cccaggaccg     4080

ctactatagc tcatcttggt cagaatgggc atctgtgccc tgcagttgac aattgctgtg     4140

ccttctagtt gccagccatc tgttgtttgc ccctcccccg tgccttcctt gaccctggaa     4200

ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca ttgtctgagt     4260

aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga ggattgggaa     4320

gacaatagca ggcatgctgg ggatgcggtg ggctctatgg agctcgagag gaacccctag     4380

tgatggagtt ggccactccc tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa     4440

aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga gcgcgcagct     4500

gcagatctg                                                             4509


<210>  55
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human CAG - modified IL-12A/IL-12B - IRES (CpG modified) 
       expression sequence

<400>  55
gctagcgcca ccatgtgtcc agcgcgcagc ctcctccttg tggctaccct ggtcctcctg       60

gaccacctca gtttggccag aaacctccct gtggccactc cagacccagg aatgttccca      120

tgccttcacc actcccaaaa cctgctgagg gctgtcagca acatgctcca gaaggccaga      180

caaactctag aattttaccc ttgcacttct gaagagattg atcatgaaga tatcacaaaa      240

gataaaacca gcacagtgga ggcctgttta ccattggaat taaccaagaa tgagagttgc      300

ctaaattcca gagagacctc tttcataact aatgggagtt gcctggcctc cagaaagacc      360

tcttttatga tggccctgtg ccttagtagt atttatgaag acttgaagat gtaccaggtg      420

gagttcaaga ccatgaatgc aaagcttctg atggatccta agaggcagat ctttctagat      480

caaaacatgc tggcagttat tgatgagctg atgcaggccc tgaatttcaa cagtgagact      540

gtgccacaaa aatcctccct tgaagaacct gatttttata aaactaaaat caagctctgc      600

atacttcttc atgctttccg gattcgcgca gtgactattg atagagtgat gagctatctg      660

aatgcttcct gagcccctct ccctcccccc cccctaacgt tactggccga agccgcttgg      720

aataaggccg gtgtgcgttt gtctatatgt tattttccac catattgccg tcttttggca      780

atgtgagggc ccggaaacct ggccctgtct tcttgacgag cattcctagg ggtctttccc      840

ctctcgccaa aggaatgcaa ggtctgttga atgtcgtgaa ggaagcagtt cctctggaag      900

cttcttgaag acaaacaacg tctgtagcga ccctttgcag gcagcggaac cccccacctg      960

gcgacaggtg cctctgcggc caaaagccac gtgtataaga tacacctgca aaggcggcac     1020

aaccccagtg ccacgttgtg agttggatag ttgtggaaag agtcaaatgg ctctcctcaa     1080

gcgtattcaa caaggggctg aaggatgccc agaaggtacc ccattgtatg ggatctgatc     1140

tggggcctcg gtacacatgc tttacatgtg tttagtcgag gttaaaaaaa cgtctaggcc     1200

ccccgaacca cggggacgtg gttttccttt gaaaaacacg atgataatat ggccacaatg     1260

tgtcaccagc agttggtcat ctcttggttt tccctggttt ttctggcatc tccccttgtg     1320

gccatatggg aactgaagaa agatgtttat gtggtagaat tggattggta tcctgatgcc     1380

cctggagaaa tggtggtcct cacctgtgac acccctgaag aagatggtat cacctggacc     1440

ttggaccaga gcagtgaggt cttaggctct ggcaaaaccc tgaccatcca agtcaaagag     1500

tttggagatg ctggccagta cacctgtcac aaaggagggg aggttctaag ccattccctc     1560

ctgctgcttc acaaaaagga agatggaatt tggtccactg atattttaaa ggaccagaaa     1620

gaacccaaaa ataagacctt tctaagatgt gaggccaaga attattctgg aaggttcacc     1680

tgctggtggc tgactacaat cagtactgat ttgacattca gtgtcaaaag cagcagaggc     1740

tcttctgacc cccaaggggt gacatgcgga gctgctacac tctctgcaga gagagtcaga     1800

ggggacaaca aggagtatga gtactcagtg gagtgccagg aggacagtgc ctgcccagct     1860

gctgaggaga gtctgcccat tgaggtgatg gtggatgcgg ttcacaagct caagtatgaa     1920

aactacacca gcagcttctt catcagggac atcatcaaac ctgacccacc caagaacttg     1980

cagctgaagc cattaaagaa ttctaggcag gtggaggtca gctgggagta ccctgacacc     2040

tggagtactc cacattccta cttctccctg acattctgtg ttcaagtcca gggcaagagc     2100

aagagagaaa agaaagatag agtcttcact gacaagacct cagccacagt catctgccgc     2160

aaaaatgcca gcatttcagt gcgggcccag gaccgctact atagctcatc ttggtcagaa     2220

tgggcatctg tgccctgcag ttgacaattg                                      2250


<210>  56
<211>  4017
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human CAG - wild-type IL-12A/IL-12B - F2A (CpG modified) 
       construct

<400>  56
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tagtattaaa cgcgtgtcga cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggg tcgaggtgag      540

ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa ttttgtattt      600

atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg cgcgcgccag      660

gcggggcggg gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca      720

atcagagcgg cgcgctccga aagtttcctt ttatggcgag gcggcggcgg cggcggccct      780

ataaaaagcg aagcgcgcgg cgggcgggag tcgctgcgcg ctgccttcgc cccgtgcccc      840

gctccgccgc cgcctcgcgc cgcccgcccc ggctctgact gaccgcgtta ctcccacagg      900

tgagcgggcg ggacggccct tctcctccgg gctgtaatta gcgcttggtt taatgacggc      960

tcgtttcttt tctgtggctg cgtgaaagcc ttgaggggct ccgggagggc cctttgtgcg     1020

gggggagcgg ctcggggggt gcgtgcgtgt gtgtgtgcgt ggggagcgcc gcgtgcggct     1080

ccgcgctgcc cggcggctgt gagcgctgcg ggcgcggcgc ggggctttgt gcgctccgca     1140

gtgtgcgcga gaggagcgcg gccgggggcg gtgccacgcg gtgcgggggg ggctgcgagg     1200

ggaacaaagg ctgcgtgcgg ggtgtgtgcg tggggggggt gagcaggggg tgtgggcgcg     1260

gcggtcgggc tgtaaccccc ccctgcaccc ccctccccga gttgctgagc acggcccggc     1320

ttcgggtgcg gggctccgtg cggggcgtgg cgcggggctc gccgtgccgg gcggggggtg     1380

gcggcgggtg ggggtgccgg gcggggcggg gccgcctcgg gccggggagg gctcggggga     1440

ggggcgcggc ggcccccgga gcgccggcgg ctgtcgaggc gcggcgagcc gcagccattg     1500

ccttttatgg taatcgtgcg agagggcgca gggacttcct ttgtcccaaa tctgtgcgga     1560

gccgaaatct gggaggcgcc gccgcacccc ctctagcggg cgcggggcga agcggtgcgg     1620

cgccggcagg aaggaaatgg gcggggaggg ccttcgtgcg tcgccgcgcc gccgtcccct     1680

tctccctctc cagcctcggg gctgtccgcg gggggacggc tgccttcggg ggggacgggg     1740

cagggcgggg ttcggcttct ggcgtgtgac cggcggtcta gactctgcta accatgttca     1800

tgccttcttc tctttcctac agctcctggg caacgtgctg gttgttgtgc tgtctcatca     1860

ttttggcaaa gaattcaagc ttccagctag cgccaccatg tgtccagcgc gcagcctcct     1920

ccttgtggct accctggtcc tcctggacca cctcagtttg gccagaaacc tccccgtggc     1980

cactccagac ccaggaatgt tcccatgcct tcaccactcc caaaacctgc tgagggccgt     2040

cagcaacatg ctccagaagg ccagacaaac tctagaattt tacccttgca cttctgaaga     2100

gattgatcat gaagatatca caaaagataa aaccagcaca gtggaggcct gtttaccatt     2160

ggaattaacc aagaatgaga gttgcctaaa ttccagagag acctctttca taactaatgg     2220

gagttgcctg gcctccagaa agacctcttt tatgatggcc ctgtgcctta gtagtattta     2280

tgaagacttg aagatgtacc aggtggagtt caagaccatg aatgcaaagc ttctgatgga     2340

tcctaagagg cagatctttc tagatcaaaa catgctggca gttattgatg agctgatgca     2400

ggccctgaat ttcaacagtg agactgtgcc acaaaaatcc tcccttgaag aaccggattt     2460

ttataaaact aaaatcaagc tctgcatact tcttcatgct ttccggattc gggcagtgac     2520

tattgataga gtgatgagct atctgaatgc ttccagaaag agaaggagtg gctcaggagc     2580

ccctgtgaaa cagaccctga actttgacct cttgaagctt gctggggatg tggagtctaa     2640

tcctggtcca atgtgtcacc agcagttggt catctcttgg ttttccctgg tttttctggc     2700

atctcccctc gtggccatat gggaactgaa gaaagatgtt tatgtcgtag aattggattg     2760

gtatccggat gcccctggag aaatggtggt cctcacctgt gacacccctg aagaagatgg     2820

tatcacctgg accttggacc agagcagtga ggtcttaggc tctggcaaaa ccctgaccat     2880

ccaagtcaaa gagtttggag atgctggcca gtacacctgt cacaaaggag gcgaggttct     2940

aagccattcg ctcctgctgc ttcacaaaaa ggaagatgga atttggtcca ctgatatttt     3000

aaaggaccag aaagaaccca aaaataagac ctttctaaga tgcgaggcca agaattattc     3060

tggacgtttc acctgctggt ggctgacgac aatcagtact gatttgacat tcagtgtcaa     3120

aagcagcaga ggctcttctg acccccaagg ggtgacgtgc ggagctgcta cactctctgc     3180

agagagagtc agaggggaca acaaggagta tgagtactca gtggagtgcc aggaggacag     3240

tgcctgccca gctgctgagg agagtctgcc cattgaggtg atggtggatg ccgttcacaa     3300

gctcaagtat gaaaactaca ccagcagctt cttcatcagg gacatcatca aacctgaccc     3360

acccaagaac ttgcagctga agccattaaa gaattctcgg caggtggagg tcagctggga     3420

gtaccctgac acctggagta ctccacattc ctacttctcc ctgacattct gcgttcaagt     3480

ccagggcaag agcaagagag aaaagaaaga tagagtcttc acggacaaga cctcagccac     3540

ggtcatctgc cgcaaaaatg ccagcattag cgtgcgggcc caggaccgct actatagctc     3600

atcttggagc gaatgggcat ctgtgccctg cagttgacaa ttgctgtgcc ttctagttgc     3660

cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc     3720

actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct     3780

attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg     3840

catgctgggg atgcggtggg ctctatggag ctcgagagga acccctagtg atggagttgg     3900

ccactccctc tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac     3960

gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc gcgcagctgc agatctg        4017


<210>  57
<211>  1758
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human CAG - wild-type IL-12A/IL-12B - F2A (CpG modified) 
       expression sequence

<400>  57
gctagcgcca ccatgtgtcc agcgcgcagc ctcctccttg tggctaccct ggtcctcctg       60

gaccacctca gtttggccag aaacctcccc gtggccactc cagacccagg aatgttccca      120

tgccttcacc actcccaaaa cctgctgagg gccgtcagca acatgctcca gaaggccaga      180

caaactctag aattttaccc ttgcacttct gaagagattg atcatgaaga tatcacaaaa      240

gataaaacca gcacagtgga ggcctgttta ccattggaat taaccaagaa tgagagttgc      300

ctaaattcca gagagacctc tttcataact aatgggagtt gcctggcctc cagaaagacc      360

tcttttatga tggccctgtg ccttagtagt atttatgaag acttgaagat gtaccaggtg      420

gagttcaaga ccatgaatgc aaagcttctg atggatccta agaggcagat ctttctagat      480

caaaacatgc tggcagttat tgatgagctg atgcaggccc tgaatttcaa cagtgagact      540

gtgccacaaa aatcctccct tgaagaaccg gatttttata aaactaaaat caagctctgc      600

atacttcttc atgctttccg gattcgggca gtgactattg atagagtgat gagctatctg      660

aatgcttcca gaaagagaag gagtggctca ggagcccctg tgaaacagac cctgaacttt      720

gacctcttga agcttgctgg ggatgtggag tctaatcctg gtccaatgtg tcaccagcag      780

ttggtcatct cttggttttc cctggttttt ctggcatctc ccctcgtggc catatgggaa      840

ctgaagaaag atgtttatgt cgtagaattg gattggtatc cggatgcccc tggagaaatg      900

gtggtcctca cctgtgacac ccctgaagaa gatggtatca cctggacctt ggaccagagc      960

agtgaggtct taggctctgg caaaaccctg accatccaag tcaaagagtt tggagatgct     1020

ggccagtaca cctgtcacaa aggaggcgag gttctaagcc attcgctcct gctgcttcac     1080

aaaaaggaag atggaatttg gtccactgat attttaaagg accagaaaga acccaaaaat     1140

aagacctttc taagatgcga ggccaagaat tattctggac gtttcacctg ctggtggctg     1200

acgacaatca gtactgattt gacattcagt gtcaaaagca gcagaggctc ttctgacccc     1260

caaggggtga cgtgcggagc tgctacactc tctgcagaga gagtcagagg ggacaacaag     1320

gagtatgagt actcagtgga gtgccaggag gacagtgcct gcccagctgc tgaggagagt     1380

ctgcccattg aggtgatggt ggatgccgtt cacaagctca agtatgaaaa ctacaccagc     1440

agcttcttca tcagggacat catcaaacct gacccaccca agaacttgca gctgaagcca     1500

ttaaagaatt ctcggcaggt ggaggtcagc tgggagtacc ctgacacctg gagtactcca     1560

cattcctact tctccctgac attctgcgtt caagtccagg gcaagagcaa gagagaaaag     1620

aaagatagag tcttcacgga caagacctca gccacggtca tctgccgcaa aaatgccagc     1680

attagcgtgc gggcccagga ccgctactat agctcatctt ggagcgaatg ggcatctgtg     1740

ccctgcagtt gacaattg                                                   1758


<210>  58
<211>  489
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-15 (with CpG modification)

<400>  58
atgagaattt cgaaaccaca tttgagaagt atttccatcc agtgctactt gtgtttactt       60

ctaaacagtc attttctaac tgaagctggc attcatgtct tcattttggg ctgtttctct      120

gctgggcttc ctaaaacaga agccaactgg gtgaatgtaa taagtgattt gaaaaaaatt      180

gaagatctta ttcaatctat gcatattgat gctactttat atacggaaag tgatgttcac      240

cccagttgca aagtaacagc aatgaagtgc tttctcttgg agttacaagt tatttcactt      300

gagtccggag atgcaagtat tcatgataca gtagaaaatc tgatcatcct agcaaacaac      360

agtttgtctt ctaatgggaa tgtaacagaa tctggatgca aagaatgtga ggaactggag      420

gaaaaaaata ttaaagaatt tttgcagagt tttgtacata ttgtccaaat gttcatcaac      480

acttcttga                                                              489


<210>  59
<211>  585
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IRES

<400>  59
gcccctctcc ctcccccccc cctaacgtta ctggccgaag ccgcttggaa taaggccggt       60

gtgcgtttgt ctatatgtta ttttccacca tattgccgtc ttttggcaat gtgagggccc      120

ggaaacctgg ccctgtcttc ttgacgagca ttcctagggg tctttcccct ctcgccaaag      180

gaatgcaagg tctgttgaat gtcgtgaagg aagcagttcc tctggaagct tcttgaagac      240

aaacaacgtc tgtagcgacc ctttgcaggc agcggaaccc cccacctggc gacaggtgcc      300

tctgcggcca aaagccacgt gtataagata cacctgcaaa ggcggcacaa ccccagtgcc      360

acgttgtgag ttggatagtt gtggaaagag tcaaatggct ctcctcaagc gtattcaaca      420

aggggctgaa ggatgcccag aaggtacccc attgtatggg atctgatctg gggcctcggt      480

acacatgctt tacatgtgtt tagtcgaggt taaaaaaacg tctaggcccc ccgaaccacg      540

gggacgtggt tttcctttga aaaacacgat gataatatgg ccaca                      585


<210>  60
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Furin cleaveage site

<400>  60
agaaagagaa ggagtggctc agga                                              24


<210>  61
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2A site

<400>  61
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaactcg       60


<210>  62
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2 leader

<400>  62
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaactcg       60


<210>  63
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-10 leader

<400>  63
atgcacagct cagcactgct ctgttgcctg gtcctcctga ctggggtgag ggcc             54


<210>  64
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  miR-142 binding site

<400>  64
tccataaagt aggaaacact aca                                               23


<210>  65
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4x miR-142 binding site

<400>  65
tccataaagt aggaaacact acactattcc ataaagtagg aaacactaca tcactccata       60

aagtaggaaa cactacaagt ctccataaag taggaaacac taca                       104


<210>  66
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SV40 intron

<400>  66
gtaagtttag tctttttgtc ttttatttca ggtcccggat ccggtggtgg tgcaaatcaa       60

agaactgctc ctcagtggat gttgccttta cttctag                                97


<210>  67
<211>  230
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EF-1alpha

<400>  67
gctccggtgc ccgtcagtgg gcagagcgca catcgcccac agtccccgag aagttggggg       60

gaggggtcgg caattgaacc ggtgcctaga gaaggtggcg cggggtaaac tgggaaagtg      120

atgtcgtgta ctggctccgc ctttttcccg agggtggggg agaaccgtat ataagtgcag      180

tagtcgccgt gaacgttctt tttcgcaacg ggtttgccgc cagaacacag                 230


<210>  68
<211>  380
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV enhancer

<400>  68
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggactatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg                                                  380


<210>  69
<211>  218
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMVp

<400>  69
gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt       60

ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac      120

tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg      180

tgggaggtct atataagcag agctcgttta gtgaaccg                              218


<210>  70
<211>  598
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV ehancer and promoter (CMVe/p)

<400>  70
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggactatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc      420

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt      480

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa      540

tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccg        598


<210>  71
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAG

<400>  71
gtcgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggact atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattacc atgggtcgag gtgagcccca cgttctgctt cactctcccc      420

atctcccccc cctccccacc cccaattttg tatttattta ttttttaatt attttgtgca      480

gcgatggggg cggggggggg gggggcgcgc gccaggcggg gcggggcggg gcgaggggcg      540

gggcggggcg aggcggagag gtgcggcggc agccaatcag agcggcgcgc tccgaaagtt      600

tccttttatg gcgaggcggc ggcggcggcg gccctataaa aagcgaagcg cgcggcgggc      660

gggagtcgct gcgcgctgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc      720

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc      780

tccgggctgt aattagcgct tggtttaatg acggctcgtt tcttttctgt ggctgcgtga      840

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggggtgcgtg      900

cgtgtgtgtg tgcgtgggga gcgccgcgtg cggctccgcg ctgcccggcg gctgtgagcg      960

ctgcgggcgc ggcgcggggc tttgtgcgct ccgcagtgtg cgcgagagga gcgcggccgg     1020

gggcggtgcc acgcggtgcg gggggggctg cgaggggaac aaaggctgcg tgcggggtgt     1080

gtgcgtgggg ggggtgagca gggggtgtgg gcgcggcggt cgggctgtaa cccccccctg     1140

cacccccctc cccgagttgc tgagcacggc ccggcttcgg gtgcggggct ccgtgcgggg     1200

cgtggcgcgg ggctcgccgt gccgggcggg gggtggcggc gggtgggggt gccgggcggg     1260

gcggggccgc ctcgggccgg ggagggctcg ggggaggggc gcggcggccc ccggagcgcc     1320

ggcggctgtc gaggcgcggc gagccgcagc cattgccttt tatggtaatc gtgcgagagg     1380

gcgcagggac ttcctttgtc ccaaatctgt gcggagccga aatctgggag gcgccgccgc     1440

accccctcta gcgggcgcgg ggcgaagcgg tgcggcgccg gcaggaagga aatgggcggg     1500

gagggccttc gtgcgtcgcc gcgccgccgt ccccttctcc ctctccagcc tcggggctgt     1560

ccgcgggggg acggctgcct tcggggggga cggggcaggg cggggttcgg cttctggcgt     1620

gtgaccggcg gtctagactc tgctaaccat gttcatgcct tcttctcttt cctacagctc     1680

ctgggcaacg tgctggttgt tgtgctgtct catcattttg gcaaa                     1725


<210>  72
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic poly(A)

<400>  72
aataaaagat ctttattttc attagatctg tgtgttggtt ttttgtgtg                   49


<210>  73
<211>  224
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGH poly(A)

<400>  73
ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc       60

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc      120

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt      180

gggaagacaa tagcaggcat gctggggatg cggtgggctc tatg                       224


<210>  74
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pause element

<400>  74
aacatacgct ctccatcaaa acaaaacgaa acaaaacaaa ctagcaaaat aggctgtccc       60

cagtgcaagt gcaggtgcca gaacatttct ct                                     92


<210>  75
<211>  269
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' LTR

<400>  75
ggggctcgca tctctccttc acgcgcccgc cgccctacct gaggccgcca tccacgccgg       60

ttgagtcgcg ttctgccgcc tcccgcctgt ggtgcctcct gaactgcgtc cgccgtctag      120

gtaagtttaa agctcaggtc gagaccgggc ctttgtccgg cgctcccttg gagcctacct      180

agactcagcc ggctctccac gctttgcctg accctgcttg ctcaactcta cgtctttgtt      240

tcgttttctg ttctgcgccg ttacagatc                                        269


<210>  76
<211>  133
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Intron (chimera of human betaglobin intron and immunoglobulin 
       heavy chain intron)

<400>  76
gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga       60

cagagaagac tcttgcgttt ctgataggca cctattggtc ttactgacat ccactttgcc      120

tttctctcca cag                                                         133


<210>  77
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IL-12A (p35) ("wild-type" no CpG modification and no stop 
       codon)

<400>  77
atgtgtccag cgcgcagcct cctccttgtg gctaccctgg tcctcctgga ccacctcagt       60

ttggccagaa acctccccgt ggccactcca gacccaggaa tgttcccatg ccttcaccac      120

tcccaaaacc tgctgagggc cgtcagcaac atgctccaga aggccagaca aactctagaa      180

ttttaccctt gcacttctga agagattgat catgaagata tcacaaaaga taaaaccagc      240

acagtggagg cctgtttacc attggaatta accaagaatg agagttgcct aaattccaga      300

gagacctctt tcataactaa tgggagttgc ctggcctcca gaaagacctc ttttatgatg      360

gccctgtgcc ttagtagtat ttatgaagac ttgaagatgt accaggtgga gttcaagacc      420

atgaatgcaa agcttctgat ggatcctaag aggcagatct ttctagatca aaacatgctg      480

gcagttattg atgagctgat gcaggccctg aatttcaaca gtgagactgt gccacaaaaa      540

tcctcccttg aagaaccgga tttttataaa actaaaatca agctctgcat acttcttcat      600

gctttccgga ttcgggcagt gactattgat agagtgatga gctatctgaa tgcttcc         657


<210>  78
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse IL-12A (p35) 

NP_001152896

<400>  78

Met Val Ser Val Pro Thr Ala Ser Pro Ser Ala Ser Ser Ser Ser Ser 
1               5                   10                  15      


Gln Cys Arg Ser Ser Met Cys Gln Ser Arg Tyr Leu Leu Phe Leu Ala 
            20                  25                  30          


Thr Leu Ala Leu Leu Asn His Leu Ser Leu Ala Arg Val Ile Pro Val 
        35                  40                  45              


Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr 
    50                  55                  60                  


Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser 
65                  70                  75                  80  


Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr 
                85                  90                  95      


Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser 
            100                 105                 110         


Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu 
        115                 120                 125             


Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile 
    130                 135                 140                 


Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala 
145                 150                 155                 160 


Ala Leu Gln Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met 
                165                 170                 175     


Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu 
            180                 185                 190         


Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val 
        195                 200                 205             


Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val 
    210                 215                 220                 


Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser Ala 
225                 230                 235     


<210>  79
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse IL-12B (p40)

NP_001290173

<400>  79

Met Cys Pro Gln Lys Leu Thr Ile Ser Trp Phe Ala Ile Val Leu Leu 
1               5                   10                  15      


Val Ser Pro Leu Met Ala Met Trp Glu Leu Glu Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln 
    50                  55                  60                  


Arg His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys 
65                  70                  75                  80  


Glu Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr 
                85                  90                  95      


Leu Ser His Ser His Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp 
            100                 105                 110         


Ser Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys 
        115                 120                 125             


Glu Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln 
    130                 135                 140                 


Arg Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro 
145                 150                 155                 160 


Asp Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys 
                165                 170                 175     


Val Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln 
            180                 185                 190         


Glu Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu 
        195                 200                 205             


Ala Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser 
    210                 215                 220                 


Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln 
225                 230                 235                 240 


Met Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro 
                245                 250                 255     


Asp Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val 
            260                 265                 270         


Arg Ile Gln Arg Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys 
        275                 280                 285             


Asn Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln 
    290                 295                 300                 


Cys Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn 
305                 310                 315                 320 


Ser Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser 
                325                 330                 335 


<210>  80
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IL-12A (p35)

NP_000873

<400>  80

Met Trp Pro Pro Gly Ser Ala Ser Gln Pro Pro Pro Ser Pro Ala Ala 
1               5                   10                  15      


Ala Thr Gly Leu His Pro Ala Ala Arg Pro Val Ser Leu Gln Cys Arg 
            20                  25                  30          


Leu Ser Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val 
        35                  40                  45              


Leu Leu Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro 
    50                  55                  60                  


Asp Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg 
65                  70                  75                  80  


Ala Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr 
                85                  90                  95      


Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys 
            100                 105                 110         


Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu 
        115                 120                 125             


Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys 
    130                 135                 140                 


Leu Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser 
145                 150                 155                 160 


Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn 
                165                 170                 175     


Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn 
            180                 185                 190         


Met Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser 
        195                 200                 205             


Glu Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys 
    210                 215                 220                 


Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala 
225                 230                 235                 240 


Val Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
                245                 250             


<210>  81
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IL-12B (p40)

NP_002178

<400>  81

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser 
                325             


<210>  82
<211>  4280
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV enhancer -CBA promoter- WT human IL-12A (no stop codon) - F2A
       - WT human IL-12B (with stop codon) -hGH polyA

<400>  82
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tagtattaaa cgcgtgtcga cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggg tcgaggtgag      540

ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa ttttgtattt      600

atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg cgcgcgccag      660

gcggggcggg gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca      720

atcagagcgg cgcgctccga aagtttcctt ttatggcgag gcggcggcgg cggcggccct      780

ataaaaagcg aagcgcgcgg cgggcgggag tcgctgcgcg ctgccttcgc cccgtgcccc      840

gctccgccgc cgcctcgcgc cgcccgcccc ggctctgact gaccgcgtta ctcccacagg      900

tgagcgggcg ggacggccct tctcctccgg gctgtaatta gcgcttggtt taatgacggc      960

tcgtttcttt tctgtggctg cgtgaaagcc ttgaggggct ccgggagggc cctttgtgcg     1020

gggggagcgg ctcggggggt gcgtgcgtgt gtgtgtgcgt ggggagcgcc gcgtgcggct     1080

ccgcgctgcc cggcggctgt gagcgctgcg ggcgcggcgc ggggctttgt gcgctccgca     1140

gtgtgcgcga gaggagcgcg gccgggggcg gtgccacgcg gtgcgggggg ggctgcgagg     1200

ggaacaaagg ctgcgtgcgg ggtgtgtgcg tggggggggt gagcaggggg tgtgggcgcg     1260

gcggtcgggc tgtaaccccc ccctgcaccc ccctccccga gttgctgagc acggcccggc     1320

ttcgggtgcg gggctccgtg cggggcgtgg cgcggggctc gccgtgccgg gcggggggtg     1380

gcggcgggtg ggggtgccgg gcggggcggg gccgcctcgg gccggggagg gctcggggga     1440

ggggcgcggc ggcccccgga gcgccggcgg ctgtcgaggc gcggcgagcc gcagccattg     1500

ccttttatgg taatcgtgcg agagggcgca gggacttcct ttgtcccaaa tctgtgcgga     1560

gccgaaatct gggaggcgcc gccgcacccc ctctagcggg cgcggggcga agcggtgcgg     1620

cgccggcagg aaggaaatgg gcggggaggg ccttcgtgcg tcgccgcgcc gccgtcccct     1680

tctccctctc cagcctcggg gctgtccgcg gggggacggc tgccttcggg ggggacgggg     1740

cagggcgggg ttcggcttct ggcgtgtgac cggcggtcta gactctgcta accatgttca     1800

tgccttcttc tctttcctac agctcctggg caacgtgctg gttgttgtgc tgtctcatca     1860

ttttggcaaa gaattcaagc ttccagctag cgccaccatg tgtccagcgc gcagcctcct     1920

ccttgtggct accctggtcc tcctggacca cctcagtttg gccagaaacc tccccgtggc     1980

cactccagac ccaggaatgt tcccatgcct tcaccactcc caaaacctgc tgagggccgt     2040

cagcaacatg ctccagaagg ccagacaaac tctagaattt tacccttgca cttctgaaga     2100

gattgatcat gaagatatca caaaagataa aaccagcaca gtggaggcct gtttaccatt     2160

ggaattaacc aagaatgaga gttgcctaaa ttccagagag acctctttca taactaatgg     2220

gagttgcctg gcctccagaa agacctcttt tatgatggcc ctgtgcctta gtagtattta     2280

tgaagacttg aagatgtacc aggtggagtt caagaccatg aatgcaaagc ttctgatgga     2340

tcctaagagg cagatctttc tagatcaaaa catgctggca gttattgatg agctgatgca     2400

ggccctgaat ttcaacagtg agactgtgcc acaaaaatcc tcccttgaag aaccggattt     2460

ttataaaact aaaatcaagc tctgcatact tcttcatgct ttccggattc gggcagtgac     2520

tattgataga gtgatgagct atctgaatgc ttccagaaag agaaggagtg gctcaggagc     2580

ccctgtgaaa cagaccctga actttgacct cttgaagctt gctggggatg tggagtctaa     2640

tcctggtcca atgtgtcacc agcagttggt catctcttgg ttttccctgg tttttctggc     2700

atctcccctc gtggccatat gggaactgaa gaaagatgtt tatgtcgtag aattggattg     2760

gtatccggat gcccctggag aaatggtggt cctcacctgt gacacccctg aagaagatgg     2820

tatcacctgg accttggacc agagcagtga ggtcttaggc tctggcaaaa ccctgaccat     2880

ccaagtcaaa gagtttggag atgctggcca gtacacctgt cacaaaggag gcgaggttct     2940

aagccattcg ctcctgctgc ttcacaaaaa ggaagatgga atttggtcca ctgatatttt     3000

aaaggaccag aaagaaccca aaaataagac ctttctaaga tgcgaggcca agaattattc     3060

tggacgtttc acctgctggt ggctgacgac aatcagtact gatttgacat tcagtgtcaa     3120

aagcagcaga ggctcttctg acccccaagg ggtgacgtgc ggagctgcta cactctctgc     3180

agagagagtc agaggggaca acaaggagta tgagtactca gtggagtgcc aggaggacag     3240

tgcctgccca gctgctgagg agagtctgcc cattgaggtg atggtggatg ccgttcacaa     3300

gctcaagtat gaaaactaca ccagcagctt cttcatcagg gacatcatca aacctgaccc     3360

acccaagaac ttgcagctga agccattaaa gaattctcgg caggtggagg tcagctggga     3420

gtaccctgac acctggagta ctccacattc ctacttctcc ctgacattct gcgttcaagt     3480

ccagggcaag agcaagagag aaaagaaaga tagagtcttc acggacaaga cctcagccac     3540

ggtcatctgc cgcaaaaatg ccagcattag cgtgcgggcc caggaccgct actatagctc     3600

atcttggagc gaatgggcat ctgtgccctg cagttgacaa ttggatctac gggtggcatc     3660

cctgtgaccc ctccccagtg cctctcctgg ccctggaagt tgccactcca gtgcccacca     3720

gccttgtcct aataaaatta agttgcatca ttttgtctga ctaggtgtcc ttctataata     3780

ttatggggtg gaggggggtg gtatggagca aggggcaagt tgggaagaca acctgtaggg     3840

cctgcggggt ctattgggaa ccaagctgga gtgcagtggc acaatcttgg ctcactgcaa     3900

tctccgcctc ctgggttcaa gcgattctcc tgcctcagcc tcccgagttg ttgggattcc     3960

aggcatgcat gaccaggctc agctaatttt tgtttttttg gtagagacgg ggtttcacca     4020

tattggccag gctggtctcc aactcctaat ctcaggtgat ctacccacct tggcctccca     4080

aattgctggg attacaggcg tgaaccactg ctcccttccc tgtccttctg gagctcgaga     4140

ggaaccccta gtgatggagt tggccactcc ctctctgcgc gctcgctcgc tcactgaggc     4200

cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg     4260

agcgcgcagc tgcagatctg                                                 4280


<210>  83
<211>  4352
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV enhancer -CBA promoter- WT mouse IL-12A (no stop codon) - F2A
       - WT mouse IL-12B (with stop codon) -hGH polyA

<400>  83
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tagtattaaa cgcgtgtcga cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggg tcgaggtgag      540

ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa ttttgtattt      600

atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg cgcgcgccag      660

gcggggcggg gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca      720

atcagagcgg cgcgctccga aagtttcctt ttatggcgag gcggcggcgg cggcggccct      780

ataaaaagcg aagcgcgcgg cgggcgggag tcgctgcgcg ctgccttcgc cccgtgcccc      840

gctccgccgc cgcctcgcgc cgcccgcccc ggctctgact gaccgcgtta ctcccacagg      900

tgagcgggcg ggacggccct tctcctccgg gctgtaatta gcgcttggtt taatgacggc      960

tcgtttcttt tctgtggctg cgtgaaagcc ttgaggggct ccgggagggc cctttgtgcg     1020

gggggagcgg ctcggggggt gcgtgcgtgt gtgtgtgcgt ggggagcgcc gcgtgcggct     1080

ccgcgctgcc cggcggctgt gagcgctgcg ggcgcggcgc ggggctttgt gcgctccgca     1140

gtgtgcgcga gaggagcgcg gccgggggcg gtgccacgcg gtgcgggggg ggctgcgagg     1200

ggaacaaagg ctgcgtgcgg ggtgtgtgcg tggggggggt gagcaggggg tgtgggcgcg     1260

gcggtcgggc tgtaaccccc ccctgcaccc ccctccccga gttgctgagc acggcccggc     1320

ttcgggtgcg gggctccgtg cggggcgtgg cgcggggctc gccgtgccgg gcggggggtg     1380

gcggcgggtg ggggtgccgg gcggggcggg gccgcctcgg gccggggagg gctcggggga     1440

ggggcgcggc ggcccccgga gcgccggcgg ctgtcgaggc gcggcgagcc gcagccattg     1500

ccttttatgg taatcgtgcg agagggcgca gggacttcct ttgtcccaaa tctgtgcgga     1560

gccgaaatct gggaggcgcc gccgcacccc ctctagcggg cgcggggcga agcggtgcgg     1620

cgccggcagg aaggaaatgg gcggggaggg ccttcgtgcg tcgccgcgcc gccgtcccct     1680

tctccctctc cagcctcggg gctgtccgcg gggggacggc tgccttcggg ggggacgggg     1740

cagggcgggg ttcggcttct ggcgtgtgac cggcggtcta gactctgcta accatgttca     1800

tgccttcttc tctttcctac agctcctggg caacgtgctg gttgttgtgc tgtctcatca     1860

ttttggcaaa gaattcaagc ttccagctag cgccaccatg gtcagcgttc caacagcctc     1920

accctcggca tccagcagct cctctcagtg ccggtccagc atgtgtcaat cacgctacct     1980

cctctttttg gccacccttg ccctcctaaa ccacctcagt ttggccaggg tcattccagt     2040

ctctggacct gccaggtgtc ttagccagtc ccgaaacctg ctgaagacca cagatgacat     2100

ggtgaagacg gccagagaaa aactgaaaca ttattcctgc actgctgaag acatcgatca     2160

tgaagacatc acacgggacc aaaccagcac attgaagacc tgtttaccac tggaactaca     2220

caagaacgag agttgcctgg ctactagaga gacttcttcc acaacaagag ggagctgcct     2280

gcccccacag aagacgtctt tgatgatgac cctgtgcctt ggtagcatct atgaggactt     2340

gaagatgtac cagacagagt tccaggccat caacgcagca cttcagaatc acaaccatca     2400

gcagatcatt ctagacaagg gcatgctggt ggccatcgat gagctgatgc agtctctgaa     2460

tcataatggc gagactctgc gccagaaacc tcctgtggga gaagcagacc cttacagagt     2520

gaaaatgaag ctctgcatcc tgcttcacgc cttcagcacc cgcgtcgtga ccatcaacag     2580

ggtgatgggc tatctgagct ccgccagaaa gagaaggagt ggctcaggag cccctgtgaa     2640

acagaccctg aactttgacc tcttgaagct tgctggggat gtggagtcta atcctggtcc     2700

aatgtgtcct cagaagctaa ccatctcctg gtttgccatc gttttgctgg tgtctccact     2760

catggccatg tgggagctgg agaaagacgt ttatgttgta gaggtggact ggactcccga     2820

tgcccctgga gaaacagtga acctcacctg tgacacgcct gaagaagatg acatcacctg     2880

gacctcagac cagagacatg gagtcatagg ctctggaaag accctgacca tcactgtcaa     2940

agagtttcta gatgctggcc agtacacctg ccacaaagga ggcgagactc tgagccactc     3000

acatctgctg ctccacaaga aggaaaatgg aatttggtcc actgaaattt taaaaaattt     3060

caaaaacaag actttcctga agtgtgaagc accaaattac tccggacggt tcacgtgctc     3120

atggctggtg caaagaaaca tggacttgaa gttcaacatc aagagcagta gcagttcccc     3180

tgactctcgg gcagtgacat gtggaatggc gtctctgtct gcagagaagg tcacactgga     3240

ccaaagggac tatgagaagt attcagtgtc ctgccaggag gatgtcacct gcccaactgc     3300

cgaggagacc ctgcccattg aactggcgtt ggaagcacgg cagcagaata aatatgagaa     3360

ctacagcacc agcttcttca tcagggacat catcaaacca gacccgccca agaacttgca     3420

gatgaagcct ttgaagaact cacaggtgga ggtcagctgg gagtaccctg actcctggag     3480

cactccccat tcctacttct ccctcaagtt ctttgttcga atccagcgca agaaagaaaa     3540

gatgaaggag acagaggagg ggtgtaacca gaaaggagcg ttcctcgtag agaagacatc     3600

taccgaagtc caatgcaaag gcgggaatgt ctgcgtgcaa gctcaggatc gctattacaa     3660

ttcctcatgc agcaagtggg catgtgttcc ctgcagggtc cgatcctgac aattggatct     3720

acgggtggca tccctgtgac ccctccccag tgcctctcct ggccctggaa gttgccactc     3780

cagtgcccac cagccttgtc ctaataaaat taagttgcat cattttgtct gactaggtgt     3840

ccttctataa tattatgggg tggagggggg tggtatggag caaggggcaa gttgggaaga     3900

caacctgtag ggcctgcggg gtctattggg aaccaagctg gagtgcagtg gcacaatctt     3960

ggctcactgc aatctccgcc tcctgggttc aagcgattct cctgcctcag cctcccgagt     4020

tgttgggatt ccaggcatgc atgaccaggc tcagctaatt tttgtttttt tggtagagac     4080

ggggtttcac catattggcc aggctggtct ccaactccta atctcaggtg atctacccac     4140

cttggcctcc caaattgctg ggattacagg cgtgaaccac tgctcccttc cctgtccttc     4200

tggagctcga gaggaacccc tagtgatgga gttggccact ccctctctgc gcgctcgctc     4260

gctcactgag gccgggcgac caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc     4320

agtgagcgag cgagcgcgca gctgcagatc tg                                   4352


<210>  84
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV2 5' ITR

<400>  84
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct                                                             130


<210>  85
<211>  276
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chicken Beta Actin (CBA) Promoter

<400>  85
tcgaggtgag ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa       60

ttttgtattt atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg      120

cgcgcgccag gcggggcggg gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg      180

gcggcagcca atcagagcgg cgcgctccga aagtttcctt ttatggcgag gcggcggcgg      240

cggcggccct ataaaaagcg aagcgcgcgg cgggcg                                276


<210>  86
<211>  1064
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAG Intron

<400>  86
ggagtcgctg cgcgctgcct tcgccccgtg ccccgctccg ccgccgcctc gcgccgcccg       60

ccccggctct gactgaccgc gttactccca caggtgagcg ggcgggacgg cccttctcct      120

ccgggctgta attagcgctt ggtttaatga cggctcgttt cttttctgtg gctgcgtgaa      180

agccttgagg ggctccggga gggccctttg tgcgggggga gcggctcggg gggtgcgtgc      240

gtgtgtgtgt gcgtggggag cgccgcgtgc ggctccgcgc tgcccggcgg ctgtgagcgc      300

tgcgggcgcg gcgcggggct ttgtgcgctc cgcagtgtgc gcgagaggag cgcggccggg      360

ggcggtgcca cgcggtgcgg ggggggctgc gaggggaaca aaggctgcgt gcggggtgtg      420

tgcgtggggg gggtgagcag ggggtgtggg cgcggcggtc gggctgtaac ccccccctgc      480

acccccctcc ccgagttgct gagcacggcc cggcttcggg tgcggggctc cgtgcggggc      540

gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggcg ggtgggggtg ccgggcgggg      600

cggggccgcc tcgggccggg gagggctcgg gggaggggcg cggcggcccc cggagcgccg      660

gcggctgtcg aggcgcggcg agccgcagcc attgcctttt atggtaatcg tgcgagaggg      720

cgcagggact tcctttgtcc caaatctgtg cggagccgaa atctgggagg cgccgccgca      780

ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg caggaaggaa atgggcgggg      840

agggccttcg tgcgtcgccg cgccgccgtc cccttctccc tctccagcct cggggctgtc      900

cgcgggggga cggctgcctt cgggggggac ggggcagggc ggggttcggc ttctggcgtg      960

tgaccggcgg tctagactct gctaaccatg ttcatgcctt cttctctttc ctacagctcc     1020

tgggcaacgt gctggttgtt gtgctgtctc atcattttgg caaa                      1064


<210>  87
<211>  5
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kozak sequence

<400>  87
gccac                                                                    5


<210>  88
<211>  487
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human growth hormone (hGH)  poly(A)

<400>  88
gatctacggg tggcatccct gtgacccctc cccagtgcct ctcctggccc tggaagttgc       60

cactccagtg cccaccagcc ttgtcctaat aaaattaagt tgcatcattt tgtctgacta      120

ggtgtccttc tataatatta tggggtggag gggggtggta tggagcaagg ggcaagttgg      180

gaagacaacc tgtagggcct gcggggtcta ttgggaacca agctggagtg cagtggcaca      240

atcttggctc actgcaatct ccgcctcctg ggttcaagcg attctcctgc ctcagcctcc      300

cgagttgttg ggattccagg catgcatgac caggctcagc taatttttgt ttttttggta      360

gagacggggt ttcaccatat tggccaggct ggtctccaac tcctaatctc aggtgatcta      420

cccaccttgg cctcccaaat tgctgggatt acaggcgtga accactgctc ccttccctgt      480

ccttctg                                                                487


<210>  89
<211>  141
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV2 3' ITR

<400>  89
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag ctgcagatct g                                                141


<210>  90
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WT mouse IL-12A (p35)(no stop codon)

<400>  90
atggtcagcg ttccaacagc ctcaccctcg gcatccagca gctcctctca gtgccggtcc       60

agcatgtgtc aatcacgcta cctcctcttt ttggccaccc ttgccctcct aaaccacctc      120

agtttggcca gggtcattcc agtctctgga cctgccaggt gtcttagcca gtcccgaaac      180

ctgctgaaga ccacagatga catggtgaag acggccagag aaaaactgaa acattattcc      240

tgcactgctg aagacatcga tcatgaagac atcacacggg accaaaccag cacattgaag      300

acctgtttac cactggaact acacaagaac gagagttgcc tggctactag agagacttct      360

tccacaacaa gagggagctg cctgccccca cagaagacgt ctttgatgat gaccctgtgc      420

cttggtagca tctatgagga cttgaagatg taccagacag agttccaggc catcaacgca      480

gcacttcaga atcacaacca tcagcagatc attctagaca agggcatgct ggtggccatc      540

gatgagctga tgcagtctct gaatcataat ggcgagactc tgcgccagaa acctcctgtg      600

ggagaagcag acccttacag agtgaaaatg aagctctgca tcctgcttca cgccttcagc      660

acccgcgtcg tgaccatcaa cagggtgatg ggctatctga gctccgcc                   708


<210>  91
<211>  1008
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WT mouse IL-12B (p40)

<400>  91
atgtgtcctc agaagctaac catctcctgg tttgccatcg ttttgctggt gtctccactc       60

atggccatgt gggagctgga gaaagacgtt tatgttgtag aggtggactg gactcccgat      120

gcccctggag aaacagtgaa cctcacctgt gacacgcctg aagaagatga catcacctgg      180

acctcagacc agagacatgg agtcataggc tctggaaaga ccctgaccat cactgtcaaa      240

gagtttctag atgctggcca gtacacctgc cacaaaggag gcgagactct gagccactca      300

catctgctgc tccacaagaa ggaaaatgga atttggtcca ctgaaatttt aaaaaatttc      360

aaaaacaaga ctttcctgaa gtgtgaagca ccaaattact ccggacggtt cacgtgctca      420

tggctggtgc aaagaaacat ggacttgaag ttcaacatca agagcagtag cagttcccct      480

gactctcggg cagtgacatg tggaatggcg tctctgtctg cagagaaggt cacactggac      540

caaagggact atgagaagta ttcagtgtcc tgccaggagg atgtcacctg cccaactgcc      600

gaggagaccc tgcccattga actggcgttg gaagcacggc agcagaataa atatgagaac      660

tacagcacca gcttcttcat cagggacatc atcaaaccag acccgcccaa gaacttgcag      720

atgaagcctt tgaagaactc acaggtggag gtcagctggg agtaccctga ctcctggagc      780

actccccatt cctacttctc cctcaagttc tttgttcgaa tccagcgcaa gaaagaaaag      840

atgaaggaga cagaggaggg gtgtaaccag aaaggagcgt tcctcgtaga gaagacatct      900

accgaagtcc aatgcaaagg cgggaatgtc tgcgtgcaag ctcaggatcg ctattacaat      960

tcctcatgca gcaagtgggc atgtgttccc tgcagggtcc gatcctga                  1008


<210>  92
<211>  984
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IL-12B (p40) ("wild-type" no CpG modification and without 
       stop codon)

<400>  92
atgtgtcacc agcagttggt catctcttgg ttttccctgg tttttctggc atctcccctc       60

gtggccatat gggaactgaa gaaagatgtt tatgtcgtag aattggattg gtatccggat      120

gcccctggag aaatggtggt cctcacctgt gacacccctg aagaagatgg tatcacctgg      180

accttggacc agagcagtga ggtcttaggc tctggcaaaa ccctgaccat ccaagtcaaa      240

gagtttggag atgctggcca gtacacctgt cacaaaggag gcgaggttct aagccattcg      300

ctcctgctgc ttcacaaaaa ggaagatgga atttggtcca ctgatatttt aaaggaccag      360

aaagaaccca aaaataagac ctttctaaga tgcgaggcca agaattattc tggacgtttc      420

acctgctggt ggctgacgac aatcagtact gatttgacat tcagtgtcaa aagcagcaga      480

ggctcttctg acccccaagg ggtgacgtgc ggagctgcta cactctctgc agagagagtc      540

agaggggaca acaaggagta tgagtactca gtggagtgcc aggaggacag tgcctgccca      600

gctgctgagg agagtctgcc cattgaggtg atggtggatg ccgttcacaa gctcaagtat      660

gaaaactaca ccagcagctt cttcatcagg gacatcatca aacctgaccc acccaagaac      720

ttgcagctga agccattaaa gaattctcgg caggtggagg tcagctggga gtaccctgac      780

acctggagta ctccacattc ctacttctcc ctgacattct gcgttcaagt ccagggcaag      840

agcaagagag aaaagaaaga tagagtcttc acggacaaga cctcagccac ggtcatctgc      900

cgcaaaaatg ccagcattag cgtgcgggcc caggaccgct actatagctc atcttggagc      960

gaatgggcat ctgtgccctg cagt                                             984


