                         SEQUENCE LISTING

<110>  Accubit LLC - Biotechnology
       JIN, Jing
 
<120>  METHODS OF TREATING IgA NEPHROPATHY WITH THIOL-CONTAINING 
       MOLECULES

<130>  20-1581-WO

<150>  US 63/090,902
<151>  2020-10-13

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  714
<212>  DNA
<213>  Rattus norvegicus

<400>  1
agctgctcat tagtatgccg cccccgttta tcgctgcagc gtcctgccct tgaggacctt       60

ttacttggat cggaagcgag cctgacctgc accctgcgcg gcctgaaaga accgaccggc      120

gcggtgttta cctggcagcc gaccaccggc aaagatgcgg tgcagaaaga agcggtgcag      180

gatagctgcg gctgctatac cgtgagcagc gtgctgccgg gctgcgcgga acgctggaac      240

aacggcgaaa cctttacctg caccgcgacc catccggaat ttgaaacccc gctgaccggc      300

gaaattgcga aagtgaccga aaacaccttt ccgccgcagg tgcatctgct gccgccgccg      360

agcgaagaac tggcgctgaa cgaactggtg agcctgacct gcctggtgcg cggctttaac      420

ccgaaagatg tgctggtgcg ctggctgcag ggcaacgaag aactgccgag cgaaagctat      480

ctggtgtttg aaccgctgcg cgaaccgggc gaaggcgcga ttacctatct ggtgaccagc      540

gtgctgcgcg tgagcgcgga aacctggaaa cagggcgcgc agtatagctg catggtgggc      600

catgaagcgc tgccgatgag ctttacccag aaaaccattg atcgcctgag cggcaaaccg      660

accaacgtga acgtgagcgt gattatgagc gaaggcgatg gcatttgcta ttag            714


<210>  2
<211>  237
<212>  PRT
<213>  Rattus norvegicus

<400>  2

Ser Cys Ser Leu Val Cys Arg Pro Arg Leu Ser Leu Gln Arg Pro Ala 
1               5                   10                  15      


Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Ser Leu Thr Cys Thr Leu 
            20                  25                  30          


Arg Gly Leu Lys Glu Pro Thr Gly Ala Val Phe Thr Trp Gln Pro Thr 
        35                  40                  45              


Thr Gly Lys Asp Ala Val Gln Lys Glu Ala Val Gln Asp Ser Cys Gly 
    50                  55                  60                  


Cys Tyr Thr Val Ser Ser Val Leu Pro Gly Cys Ala Glu Arg Trp Asn 
65                  70                  75                  80  


Asn Gly Glu Thr Phe Thr Cys Thr Ala Thr His Pro Glu Phe Glu Thr 
                85                  90                  95      


Pro Leu Thr Gly Glu Ile Ala Lys Val Thr Glu Asn Thr Phe Pro Pro 
            100                 105                 110         


Gln Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn Glu 
        115                 120                 125             


Leu Val Ser Leu Thr Cys Leu Val Arg Gly Phe Asn Pro Lys Asp Val 
    130                 135                 140                 


Leu Val Arg Trp Leu Gln Gly Asn Glu Glu Leu Pro Ser Glu Ser Tyr 
145                 150                 155                 160 


Leu Val Phe Glu Pro Leu Arg Glu Pro Gly Glu Gly Ala Ile Thr Tyr 
                165                 170                 175     


Leu Val Thr Ser Val Leu Arg Val Ser Ala Glu Thr Trp Lys Gln Gly 
            180                 185                 190         


Ala Gln Tyr Ser Cys Met Val Gly His Glu Ala Leu Pro Met Ser Phe 
        195                 200                 205             


Thr Gln Lys Thr Ile Asp Arg Leu Ser Gly Lys Pro Thr Asn Val Asn 
    210                 215                 220                 


Val Ser Val Ile Met Ser Glu Gly Asp Gly Ile Cys Tyr 
225                 230                 235         


<210>  3
<211>  714
<212>  DNA
<213>  Rattus norvegicus

<400>  3
agctgctcat tagtatgccg cccccgttta tcgctgcagc gtcctgccct tgaggacctt       60

ttacttggat cggaagcgag cctgacctgc accctgcgcg gcctgaaaga accgaccggc      120

gcggtgttta cctggcagcc gaccaccggc aaagatgcgg tgcagaaaga agcggtgcag      180

gatagctgcg gctgctatac cgtgagcagc gtgctgccgg gctgcgcgga acgctggaac      240

aacggcgaaa cctttacctg caccgcgacc catccggaat ttgaaacccc gctgaccggc      300

gaaattgcga aagtgaccga aaacaccttt ccgccgcagg tgcatctgct gccgccgccg      360

agcgaagaac tggcgctgaa cgaactggtg agcctgacct gcctggtgcg cggctttaac      420

ccgaaagatg tgctggtgcg ctggctgcag ggcaacgaag aactgccgag cgaaagctat      480

ctggtgtttg aaccgctgcg cgaaccgggc gaaggcgcga ttacctatct ggtgaccagc      540

gtgctgcgcg tgagcgcgga aacctggaaa cagggcgcgc agtatagctg catggtgggc      600

catgaagcgc tgccgatgag ctttacccag aaaaccattg atcgcctgag cggcaaaccg      660

accaacgtga acgtgagcgt gattatgagc gaaggcgatg gcattagcta ttag            714


<210>  4
<211>  237
<212>  PRT
<213>  Rattus norvegicus

<400>  4

Ser Cys Ser Leu Val Cys Arg Pro Arg Leu Ser Leu Gln Arg Pro Ala 
1               5                   10                  15      


Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Ser Leu Thr Cys Thr Leu 
            20                  25                  30          


Arg Gly Leu Lys Glu Pro Thr Gly Ala Val Phe Thr Trp Gln Pro Thr 
        35                  40                  45              


Thr Gly Lys Asp Ala Val Gln Lys Glu Ala Val Gln Asp Ser Cys Gly 
    50                  55                  60                  


Cys Tyr Thr Val Ser Ser Val Leu Pro Gly Cys Ala Glu Arg Trp Asn 
65                  70                  75                  80  


Asn Gly Glu Thr Phe Thr Cys Thr Ala Thr His Pro Glu Phe Glu Thr 
                85                  90                  95      


Pro Leu Thr Gly Glu Ile Ala Lys Val Thr Glu Asn Thr Phe Pro Pro 
            100                 105                 110         


Gln Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn Glu 
        115                 120                 125             


Leu Val Ser Leu Thr Cys Leu Val Arg Gly Phe Asn Pro Lys Asp Val 
    130                 135                 140                 


Leu Val Arg Trp Leu Gln Gly Asn Glu Glu Leu Pro Ser Glu Ser Tyr 
145                 150                 155                 160 


Leu Val Phe Glu Pro Leu Arg Glu Pro Gly Glu Gly Ala Ile Thr Tyr 
                165                 170                 175     


Leu Val Thr Ser Val Leu Arg Val Ser Ala Glu Thr Trp Lys Gln Gly 
            180                 185                 190         


Ala Gln Tyr Ser Cys Met Val Gly His Glu Ala Leu Pro Met Ser Phe 
        195                 200                 205             


Thr Gln Lys Thr Ile Asp Arg Leu Ser Gly Lys Pro Thr Asn Val Asn 
    210                 215                 220                 


Val Ser Val Ile Met Ser Glu Gly Asp Gly Ile Ser Tyr 
225                 230                 235         


<210>  5
<211>  714
<212>  DNA
<213>  Rattus norvegicus

<400>  5
agctgctcat tagtatgccg cccccgttta tcgctgcagc gtcctgccct tgaggacctt       60

ttacttggat cggaagcgag cctgacctgc accctgcgcg gcctgaaaga accgaccggc      120

gcggtgttta cctggcagcc gaccaccggc aaagatgcgg tgcagaaaga agcggtgcag      180

gatagctgcg gctgctatac cgtgagcagc gtgctgccgg gctccgcgga acgctggaac      240

aacggcgaaa cctttacctg caccgcgacc catccggaat ttgaaacccc gctgaccggc      300

gaaattgcga aagtgaccga aaacaccttt ccgccgcagg tgcatctgct gccgccgccg      360

agcgaagaac tggcgctgaa cgaactggtg agcctgacct gcctggtgcg cggctttaac      420

ccgaaagatg tgctggtgcg ctggctgcag ggcaacgaag aactgccgag cgaaagctat      480

ctggtgtttg aaccgctgcg cgaaccgggc gaaggcgcga ttacctatct ggtgaccagc      540

gtgctgcgcg tgagcgcgga aacctggaaa cagggcgcgc agtatagctg catggtgggc      600

catgaagcgc tgccgatgag ctttacccag aaaaccattg atcgcctgag cggcaaaccg      660

accaacgtga acgtgagcgt gattatgagc gaaggcgatg gcatttgcta ttag            714


<210>  6
<211>  237
<212>  PRT
<213>  Rattus norvegicus

<400>  6

Ser Cys Ser Leu Val Cys Arg Pro Arg Leu Ser Leu Gln Arg Pro Ala 
1               5                   10                  15      


Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Ser Leu Thr Cys Thr Leu 
            20                  25                  30          


Arg Gly Leu Lys Glu Pro Thr Gly Ala Val Phe Thr Trp Gln Pro Thr 
        35                  40                  45              


Thr Gly Lys Asp Ala Val Gln Lys Glu Ala Val Gln Asp Ser Cys Gly 
    50                  55                  60                  


Cys Tyr Thr Val Ser Ser Val Leu Pro Gly Ser Ala Glu Arg Trp Asn 
65                  70                  75                  80  


Asn Gly Glu Thr Phe Thr Cys Thr Ala Thr His Pro Glu Phe Glu Thr 
                85                  90                  95      


Pro Leu Thr Gly Glu Ile Ala Lys Val Thr Glu Asn Thr Phe Pro Pro 
            100                 105                 110         


Gln Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn Glu 
        115                 120                 125             


Leu Val Ser Leu Thr Cys Leu Val Arg Gly Phe Asn Pro Lys Asp Val 
    130                 135                 140                 


Leu Val Arg Trp Leu Gln Gly Asn Glu Glu Leu Pro Ser Glu Ser Tyr 
145                 150                 155                 160 


Leu Val Phe Glu Pro Leu Arg Glu Pro Gly Glu Gly Ala Ile Thr Tyr 
                165                 170                 175     


Leu Val Thr Ser Val Leu Arg Val Ser Ala Glu Thr Trp Lys Gln Gly 
            180                 185                 190         


Ala Gln Tyr Ser Cys Met Val Gly His Glu Ala Leu Pro Met Ser Phe 
        195                 200                 205             


Thr Gln Lys Thr Ile Asp Arg Leu Ser Gly Lys Pro Thr Asn Val Asn 
    210                 215                 220                 


Val Ser Val Ile Met Ser Glu Gly Asp Gly Ile Cys Tyr 
225                 230                 235         


<210>  7
<211>  714
<212>  DNA
<213>  Rattus norvegicus

<400>  7
agctgctcat tagtatgccg cccccgttta tcgctgcagc gtcctgccct tgaggacctt       60

ttacttggat cggaagcgag cctgacctgc accctgcgcg gcctgaaaga accgaccggc      120

gcggtgttta cctggcagcc gaccaccggc aaagatgcgg tgcagaaaga agcggtgcag      180

gatagctgcg gctgctatac cgtgagcagc gtgctgccgg gctccgcgga acgctggaac      240

aacggcgaaa cctttacctg caccgcgacc catccggaat ttgaaacccc gctgaccggc      300

gaaattgcga aagtgaccga aaacaccttt ccgccgcagg tgcatctgct gccgccgccg      360

agcgaagaac tggcgctgaa cgaactggtg agcctgacct gcctggtgcg cggctttaac      420

ccgaaagatg tgctggtgcg ctggctgcag ggcaacgaag aactgccgag cgaaagctat      480

ctggtgtttg aaccgctgcg cgaaccgggc gaaggcgcga ttacctatct ggtgaccagc      540

gtgctgcgcg tgagcgcgga aacctggaaa cagggcgcgc agtatagctg catggtgggc      600

catgaagcgc tgccgatgag ctttacccag aaaaccattg atcgcctgag cggcaaaccg      660

accaacgtga acgtgagcgt gattatgagc gaaggcgatg gcattagcta ttag            714


<210>  8
<211>  237
<212>  PRT
<213>  Rattus norvegicus

<400>  8

Ser Cys Ser Leu Val Cys Arg Pro Arg Leu Ser Leu Gln Arg Pro Ala 
1               5                   10                  15      


Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Ser Leu Thr Cys Thr Leu 
            20                  25                  30          


Arg Gly Leu Lys Glu Pro Thr Gly Ala Val Phe Thr Trp Gln Pro Thr 
        35                  40                  45              


Thr Gly Lys Asp Ala Val Gln Lys Glu Ala Val Gln Asp Ser Cys Gly 
    50                  55                  60                  


Cys Tyr Thr Val Ser Ser Val Leu Pro Gly Ser Ala Glu Arg Trp Asn 
65                  70                  75                  80  


Asn Gly Glu Thr Phe Thr Cys Thr Ala Thr His Pro Glu Phe Glu Thr 
                85                  90                  95      


Pro Leu Thr Gly Glu Ile Ala Lys Val Thr Glu Asn Thr Phe Pro Pro 
            100                 105                 110         


Gln Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn Glu 
        115                 120                 125             


Leu Val Ser Leu Thr Cys Leu Val Arg Gly Phe Asn Pro Lys Asp Val 
    130                 135                 140                 


Leu Val Arg Trp Leu Gln Gly Asn Glu Glu Leu Pro Ser Glu Ser Tyr 
145                 150                 155                 160 


Leu Val Phe Glu Pro Leu Arg Glu Pro Gly Glu Gly Ala Ile Thr Tyr 
                165                 170                 175     


Leu Val Thr Ser Val Leu Arg Val Ser Ala Glu Thr Trp Lys Gln Gly 
            180                 185                 190         


Ala Gln Tyr Ser Cys Met Val Gly His Glu Ala Leu Pro Met Ser Phe 
        195                 200                 205             


Thr Gln Lys Thr Ile Asp Arg Leu Ser Gly Lys Pro Thr Asn Val Asn 
    210                 215                 220                 


Val Ser Val Ile Met Ser Glu Gly Asp Gly Ile Ser Tyr 
225                 230                 235         


<210>  9
<211>  702
<212>  DNA
<213>  Homo sapiens

<400>  9
agctgctgcc atccgcgctt atcgcttcac cgccctgcat tggaggattt gttacttggt       60

tcagaggcca atctgacgtg taccctgacc ggcctgcgcg atgcgagcgg cgtgaccttt      120

acctggaccc cgagcagcgg caaaagcgcg gtgcagggcc cgccggaacg cgatctgtgc      180

ggctgctata gcgtgagcag cgtgctgccg ggctgcgcgg aaccgtggaa ccacggcaaa      240

acctttacct gcaccgcggc gtatccggaa agcaaaaccc cgctgaccgc gaccctgagc      300

aaaagcggca acacctttcg cccggaagtg catctgctgc cgccgccgag cgaagaactg      360

gcgctgaacg aactggtgac cctgacctgc ctggcgcgcg gctttagccc gaaagatgtg      420

ctggtgcgct ggctgcaggg cagccaggaa ctgccgcgcg aaaaatatct gacctgggcg      480

agccgccagg aaccgagcca gggcaccacc acctttgcgg tgaccagcat tctgcgcgtg      540

gcggcggaag attggaaaaa aggcgatacc tttagctgca tggtgggcca tgaagcgctg      600

ccgctggcgt ttacccagaa aaccattgat cgcctggcgg gcaaaccgac ccatgtgaac      660

gtgagcgtgg tgatggcgga agtggatggc acctgctatt ag                         702


<210>  10
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  10

Ser Cys Cys His Pro Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp 
1               5                   10                  15      


Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu 
            20                  25                  30          


Arg Asp Ala Ser Gly Val Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys 
        35                  40                  45              


Ser Ala Val Gln Gly Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser 
    50                  55                  60                  


Val Ser Ser Val Leu Pro Gly Cys Ala Glu Pro Trp Asn His Gly Lys 
65                  70                  75                  80  


Thr Phe Thr Cys Thr Ala Ala Tyr Pro Glu Ser Lys Thr Pro Leu Thr 
                85                  90                  95      


Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe Arg Pro Glu Val His Leu 
            100                 105                 110         


Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn Glu Leu Val Thr Leu 
        115                 120                 125             


Thr Cys Leu Ala Arg Gly Phe Ser Pro Lys Asp Val Leu Val Arg Trp 
    130                 135                 140                 


Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala 
145                 150                 155                 160 


Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr Thr Phe Ala Val Thr Ser 
                165                 170                 175     


Ile Leu Arg Val Ala Ala Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser 
            180                 185                 190         


Cys Met Val Gly His Glu Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr 
        195                 200                 205             


Ile Asp Arg Leu Ala Gly Lys Pro Thr His Val Asn Val Ser Val Val 
    210                 215                 220                 


Met Ala Glu Val Asp Gly Thr Cys Tyr 
225                 230             


<210>  11
<211>  702
<212>  DNA
<213>  Homo sapiens

<400>  11
agctgctgcc atccgcgctt atcgcttcac cgccctgcat tggaggattt gttacttggt       60

tcagaggcca atctgacgtg taccctgacc ggcctgcgcg atgcgagcgg cgtgaccttt      120

acctggaccc cgagcagcgg caaaagcgcg gtgcagggcc cgccggaacg cgatctgtgc      180

ggctgctata gcgtgagcag cgtgctgccg ggctgcgcgg aaccgtggaa ccacggcaaa      240

acctttacct gcaccgcggc gtatccggaa agcaaaaccc cgctgaccgc gaccctgagc      300

aaaagcggca acacctttcg cccggaagtg catctgctgc cgccgccgag cgaagaactg      360

gcgctgaacg aactggtgac cctgacctgc ctggcgcgcg gctttagccc gaaagatgtg      420

ctggtgcgct ggctgcaggg cagccaggaa ctgccgcgcg aaaaatatct gacctgggcg      480

agccgccagg aaccgagcca gggcaccacc acctttgcgg tgaccagcat tctgcgcgtg      540

gcggcggaag attggaaaaa aggcgatacc tttagctgca tggtgggcca tgaagcgctg      600

ccgctggcgt ttacccagaa aaccattgat cgcctggcgg gcaaaccgac ccatgtgaac      660

gtgagcgtgg tgatggcgga agtggatggc accagctatt ag                         702


<210>  12
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  12

Ser Cys Cys His Pro Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp 
1               5                   10                  15      


Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu 
            20                  25                  30          


Arg Asp Ala Ser Gly Val Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys 
        35                  40                  45              


Ser Ala Val Gln Gly Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser 
    50                  55                  60                  


Val Ser Ser Val Leu Pro Gly Cys Ala Glu Pro Trp Asn His Gly Lys 
65                  70                  75                  80  


Thr Phe Thr Cys Thr Ala Ala Tyr Pro Glu Ser Lys Thr Pro Leu Thr 
                85                  90                  95      


Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe Arg Pro Glu Val His Leu 
            100                 105                 110         


Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn Glu Leu Val Thr Leu 
        115                 120                 125             


Thr Cys Leu Ala Arg Gly Phe Ser Pro Lys Asp Val Leu Val Arg Trp 
    130                 135                 140                 


Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala 
145                 150                 155                 160 


Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr Thr Phe Ala Val Thr Ser 
                165                 170                 175     


Ile Leu Arg Val Ala Ala Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser 
            180                 185                 190         


Cys Met Val Gly His Glu Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr 
        195                 200                 205             


Ile Asp Arg Leu Ala Gly Lys Pro Thr His Val Asn Val Ser Val Val 
    210                 215                 220                 


Met Ala Glu Val Asp Gly Thr Ser Tyr 
225                 230             


