                         SEQUENCE LISTING

<110>  Sun Pharmaceutical Industries Limited
 
<120>  NOVEL GLP-1/GIP DUAL AGONISTS

<130>  SPIL-1779WO-GLP1GIP-2

<150>  IN 202021045240
<151>  2020-10-17

<150>  IN 202121002837
<151>  2021-01-20

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  The acid group of the C terminal amino acid is a free carboxylic 
       acid  or is amidated as C-terminal primary amide

<220>
<221>  MISC_FEATURE
<223>  at least one of X3 and X5 is Lys

<220>
<221>  MISC_FEATURE
<223>  when X1 is Aib, X2 is not Aib

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib (2-Aminoisobutyric acid), L-norvaline or D-norvaline

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa =  Aib (2-Aminoisobutyric acid), Leu, (D)-Leu, Val, (D)-Val, 
       Ile, (D)-Ile or an modified amino acid of Formula 
       -[NH-CH(R)-C(O)]-

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa = Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa = Gln or Ala

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa = Gln or Lys; wherein, when Lys, the side chain amino 
       (Epsilon amino) group of Lys is substituted

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa = Ala or Glu

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa = Gln or Asn

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa = Leu, Ile or Glu

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa = absent, Arg or Lys; wherein when Lys, the side chain amino 
       (Epsilon amino) group of Lys is substituted

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = absent or Lys

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  Xaa = absent or Lys

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  Xaa = absent or Lys

<220>
<221>  MISC_FEATURE
<222>  (44)..(44)
<223>  Xaa = absent or Lys

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  Xaa = absent or Lys

<220>
<221>  MISC_FEATURE
<222>  (46)..(46)
<223>  Xaa = absent or Lys

<400>  1

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Leu Xaa Lys 
1               5                   10                  15      


Ile Ala Xaa Xaa Xaa Phe Val Xaa Trp Leu Xaa Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45      


<210>  2
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  The acid group of the C terminal amino acid is a free carboxylic 
       acid  or is amidated as C-terminal primary amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib (2-Aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = Leu, Ile, L-norvaline, L-homoalanine or L-norleucine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa = Lys,  wherein the side chain amino (Epsilon amino) group of
       Lys is substituted

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa = Ile

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa= absent or Arg

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = absent or Lys

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  Xaa = absent or Lys

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  Xaa = absent or Lys

<220>
<221>  MISC_FEATURE
<222>  (44)..(44)
<223>  Xaa = absent or Lys

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  Xaa = absent or Lys

<220>
<221>  MISC_FEATURE
<222>  (46)..(46)
<223>  Xaa = absent or Lys

<400>  2

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Leu Asp Lys 
1               5                   10                  15      


Ile Ala Gln Xaa Ala Phe Val Gln Trp Leu Xaa Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45      


<210>  3
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  The acid group of the C terminal amino acid is is a free 
       carboxylic acid  or is amidated as C-terminal primary amide

<220>
<221>  MISC_FEATURE
<223>  when X1 is Aib, X2 is not Aib

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib (2-Aminoisobutyric acid) or L-norvaline

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = Aib, Leu, Ile, L-norvaline, L-homoalanine or L-norleucine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa = Lys,  wherein the side chain amino (Epsilon amino) group of
       Lys is substituted

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa = Ile

<400>  3

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Leu Asp Lys 
1               5                   10                  15      


Ile Ala Gln Xaa Ala Phe Val Gln Trp Leu Xaa Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  4
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib (2-Aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = L-Norvaline

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Side chain amino (Epsilon amino) group of Lys is substituted

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  Ser at position 39 is amidated as a C-terminal primary amide

<400>  4

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Leu Asp Lys 
1               5                   10                  15      


Ile Ala Gln Lys Ala Phe Val Gln Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  5
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = L-Norvaline

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = Aib (2-Aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Side chain amino (Epsilon amino) group of Lys is substituted

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  Ser at position 39 is amidated as a C-terminal primary amide

<400>  5

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Leu Asp Lys 
1               5                   10                  15      


Ile Ala Gln Lys Ala Phe Val Gln Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  6
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib (2-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Side chain amino (Epsilon amino) group of Lys is substituted

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  Ser at position 39 is amidated as a C-terminal primary amide

<400>  6

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Leu Leu Asp Lys 
1               5                   10                  15      


Ile Ala Gln Lys Ala Phe Val Gln Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  7
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = L-Norvaline

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = L-Norvaline

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Side chain amino (Epsilon amino) group of Lys is substituted

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  Ser at position 39 is amidated as a C-terminal primary amide

<400>  7

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Leu Asp Lys 
1               5                   10                  15      


Ile Ala Gln Lys Ala Phe Val Gln Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  8
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib (2-Aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = L-Norvaline

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Side chain amino (Epsilon amino) group of Lys is substituted

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Lys at position 40 is amidated as a C-terminal primary amide

<400>  8

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Leu Glu Lys 
1               5                   10                  15      


Ile Ala Ala Gln Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  9
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib (2-Aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = L-Norvaline

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Side chain amino (Epsilon amino) group of Lys is substituted

<400>  9

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Leu Asp Lys 
1               5                   10                  15      


Ile Ala Gln Lys Ala Phe Val Gln Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Arg 
        35                  40  


<210>  10
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib (2-Aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = L-homoalanine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Side chain amino (Epsilon amino) group of Lys is substituted

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  Ser at position 39 is amidated as a C-terminal primary amide

<400>  10

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Leu Asp Lys 
1               5                   10                  15      


Ile Ala Gln Lys Ala Phe Val Gln Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  11
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib (2-Aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = L-Norleucine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Side chain amino (Epsilon amino) group of Lys is substituted

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  Ser at position 39 is amidated as a C-terminal primary amide

<400>  11

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Leu Asp Lys 
1               5                   10                  15      


Ile Ala Gln Lys Ala Phe Val Gln Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  12
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib (2-Aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Side chain amino (Epsilon amino) group of Lys is substituted

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  Ser at position 39 is amidated as a C-terminal primary amide

<400>  12

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Ile Leu Asp Lys 
1               5                   10                  15      


Ile Ala Gln Lys Ala Phe Val Gln Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


