                         SEQUENCE LISTING

<110>  Icosagen Cell Factory OU
 
<120>  SARS CoV-2 neutralizing antibodies

<130>  11344-009WO

<160>  98    

<170>  PatentIn version 3.5

<210>  1
<211>  582
<212>  DNA
<213>  Coronavirus SARS-Cov-2


<220>
<221>  misc_feature
<222>  (1)..(582)
<223>  Receptor binding domain

<400>  1
aatatcacaa acctgtgccc atttggcgag gtgttcaacg caacccgctt cgccagcgtg       60

tacgcctgga ataggaagcg gatcagcaac tgcgtggccg actatagcgt gctgtacaac      120

tccgcctctt tcagcacctt taagtgctat ggcgtgtccc ccacaaagct gaatgacctg      180

tgctttacca acgtctacgc cgattctttc gtgatcaggg gcgacgaggt gcgccagatc      240

gcccccggcc agacaggcaa gatcgcagac tacaattata agctgccaga cgatttcacc      300

ggctgcgtga tcgcctggaa cagcaacaat ctggattcca aagtgggcgg caactacaat      360

tatctgtacc ggctgtttag aaagagcaat ctgaagccct tcgagaggga catctctaca      420

gaaatctacc aggccggcag caccccttgc aatggcgtgg agggctttaa ctgttatttc      480

ccactccagt cctacggctt ccagcccaca aacggcgtgg gctatcagcc ttaccgcgtg      540

gtggtgctga gctttgagct gctgcacgcc ccagcaacag tg                         582


<210>  2
<211>  194
<212>  PRT
<213>  Coronavirus SARS-Cov-2


<220>
<221>  MISC_FEATURE
<222>  (1)..(194)
<223>  Receptor binding domain

<400>  2

Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
            180                 185                 190         


Thr Val 
        


<210>  3
<211>  669
<212>  DNA
<213>  Coronavirus SARS-CoV-2


<220>
<221>  misc_feature
<222>  (1)..(669)
<223>  Receptor binding domain -2

<400>  3
agggtgcagc caaccgagtc tatcgtgcgc tttcctaata tcacaaacct gtgcccattt       60

ggcgaggtgt tcaacgcaac ccgcttcgcc agcgtgtacg cctggaatag gaagcggatc      120

agcaactgcg tggccgacta tagcgtgctg tacaactccg cctctttcag cacctttaag      180

tgctatggcg tgtcccccac aaagctgaat gacctgtgct ttaccaacgt ctacgccgat      240

tctttcgtga tcaggggcga cgaggtgcgc cagatcgccc ccggccagac aggcaagatc      300

gcagactaca attataagct gccagacgat ttcaccggct gcgtgatcgc ctggaacagc      360

aacaatctgg attccaaagt gggcggcaac tacaattatc tgtaccggct gtttagaaag      420

agcaatctga agcccttcga gagggacatc tctacagaaa tctaccaggc cggcagcacc      480

ccttgcaatg gcgtggaggg ctttaactgt tatttcccac tccagtccta cggcttccag      540

cccacaaacg gcgtgggcta tcagccttac cgcgtggtgg tgctgagctt tgagctgctg      600

cacgccccag caacagtgtg cggccccaag aagtccacca atctggtgaa gaacaagtgc      660

gtgaacttc                                                              669


<210>  4
<211>  223
<212>  PRT
<213>  Coronavirus SARS-Cov-4


<220>
<221>  MISC_FEATURE
<222>  (1)..(223)
<223>  Receptor Binding Domain -2

<400>  4

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
    210                 215                 220             


<210>  5
<211>  2016
<212>  DNA
<213>  Coronavirus SARS-Cov-2


<220>
<221>  misc_feature
<222>  (1)..(2016)
<223>  S1 Domain

<400>  5
cagtgcgtca atctgacaac tcggactcag ctgccacctg cttatactaa tagcttcacc       60

agaggcgtgt actatcctga caaggtgttt agaagctccg tgctgcactc tacacaggat      120

ctgtttctgc cattctttag caacgtgacc tggttccacg ccatccacgt gagcggcacc      180

aatggcacaa agcggttcga caatcccgtg ctgcctttta acgatggcgt gtacttcgcc      240

tctaccgaga agagcaacat catcagaggc tggatctttg gcaccacact ggactccaag      300

acacagtctc tgctgatcgt gaacaatgcc accaacgtgg tcatcaaggt gtgcgagttc      360

cagttttgta atgatccctt cctgggcgtg tactatcaca agaacaataa gagctggatg      420

gagtccgagt ttagagtgta ttctagcgcc aacaactgca catttgagta cgtgagccag      480

cctttcctga tggacctgga gggcaagcag ggcaatttca agaacctgag ggagttcgtg      540

tttaagaata tcgacggcta cttcaaaatc tactctaagc acacccccat caacctggtg      600

cgcgacctgc ctcagggctt cagcgccctg gagcccctgg tggatctgcc tatcggcatc      660

aacatcaccc ggtttcagac actgctggcc ctgcacagaa gctacctgac acccggcgac      720

tcctctagcg gatggaccgc cggcgctgcc gcctactatg tgggctacct ccagccccgg      780

accttcctgc tgaagtacaa cgagaatggc accatcacag acgcagtgga ttgcgccctg      840

gaccccctga gcgagacaaa gtgtacactg aagtccttta ccgtggagaa gggcatctat      900

cagacatcca atttcagggt gcagccaacc gagtctatcg tgcgctttcc taatatcaca      960

aacctgtgcc catttggcga ggtgttcaac gcaacccgct tcgccagcgt gtacgcctgg     1020

aataggaagc ggatcagcaa ctgcgtggcc gactatagcg tgctgtacaa ctccgcctct     1080

ttcagcacct ttaagtgcta tggcgtgtcc cccacaaagc tgaatgacct gtgctttacc     1140

aacgtctacg ccgattcttt cgtgatcagg ggcgacgagg tgcgccagat cgcccccggc     1200

cagacaggca agatcgcaga ctacaattat aagctgccag acgatttcac cggctgcgtg     1260

atcgcctgga acagcaacaa tctggattcc aaagtgggcg gcaactacaa ttatctgtac     1320

cggctgttta gaaagagcaa tctgaagccc ttcgagaggg acatctctac agaaatctac     1380

caggccggca gcaccccttg caatggcgtg gagggcttta actgttattt cccactccag     1440

tcctacggct tccagcccac aaacggcgtg ggctatcagc cttaccgcgt ggtggtgctg     1500

agctttgagc tgctgcacgc cccagcaaca gtgtgcggcc ccaagaagtc caccaatctg     1560

gtgaagaaca agtgcgtgaa cttcaacttc aacggcctga ccggcacagg cgtgctgacc     1620

gagtccaaca agaagttcct gccatttcag cagttcggca gggacatcgc agataccaca     1680

gacgccgtgc gcgacccaca gaccctggag atcctggaca tcacaccctg ctctttcggc     1740

ggcgtgagcg tgatcacacc cggcaccaat acaagcaacc aggtggccgt gctgtatcag     1800

gacgtgaatt gtaccgaggt gcccgtggct atccacgccg atcagctgac cccaacatgg     1860

cgggtgtaca gcaccggctc caacgtcttc cagacaagag ccggatgcct gatcggagca     1920

gagcacgtga acaattccta tgagtgcgac atcccaatcg gcgccggcat ctgtgcctct     1980

taccagaccc agacaaactc tcccagaaga gcccgg                               2016


<210>  6
<211>  672
<212>  PRT
<213>  Coronavirus SARS-CoV-2


<220>
<221>  MISC_FEATURE
<222>  (1)..(672)
<223>  S1 domain

<400>  6

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
                325                 330                 335     


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
            420                 425                 430         


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
        435                 440                 445             


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
    450                 455                 460                 


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
465                 470                 475                 480 


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
                485                 490                 495     


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
            500                 505                 510         


Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
        515                 520                 525             


Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys 
    530                 535                 540                 


Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr 
545                 550                 555                 560 


Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
                565                 570                 575     


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
            580                 585                 590         


Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro 
        595                 600                 605             


Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser 
    610                 615                 620                 


Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala 
625                 630                 635                 640 


Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly 
                645                 650                 655     


Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg 
            660                 665                 670         


<210>  7
<211>  3681
<212>  DNA
<213>  Coronavirus SARS-CoV-2


<220>
<221>  misc_feature
<222>  (1)..(3681)
<223>  Extracellular Domain

<220>
<221>  misc_feature
<222>  (1)..(3681)
<223>  Spike Extracellular Domain

<400>  7
cagtgcgtca atctgacaac tcggactcag ctgccacctg cttatactaa tagcttcacc       60

agaggcgtgt actatcctga caaggtgttt agaagctccg tgctgcactc tacacaggat      120

ctgtttctgc cattctttag caacgtgacc tggttccacg ccatccacgt gagcggcacc      180

aatggcacaa agcggttcga caatcccgtg ctgcctttta acgatggcgt gtacttcgcc      240

tctaccgaga agagcaacat catcagaggc tggatctttg gcaccacact ggactccaag      300

acacagtctc tgctgatcgt gaacaatgcc accaacgtgg tcatcaaggt gtgcgagttc      360

cagttttgta atgatccctt cctgggcgtg tactatcaca agaacaataa gagctggatg      420

gagtccgagt ttagagtgta ttctagcgcc aacaactgca catttgagta cgtgagccag      480

cctttcctga tggacctgga gggcaagcag ggcaatttca agaacctgag ggagttcgtg      540

tttaagaata tcgacggcta cttcaaaatc tactctaagc acacccccat caacctggtg      600

cgcgacctgc ctcagggctt cagcgccctg gagcccctgg tggatctgcc tatcggcatc      660

aacatcaccc ggtttcagac actgctggcc ctgcacagaa gctacctgac acccggcgac      720

tcctctagcg gatggaccgc cggcgctgcc gcctactatg tgggctacct ccagccccgg      780

accttcctgc tgaagtacaa cgagaatggc accatcacag acgcagtgga ttgcgccctg      840

gaccccctga gcgagacaaa gtgtacactg aagtccttta ccgtggagaa gggcatctat      900

cagacatcca atttcagggt gcagccaacc gagtctatcg tgcgctttcc taatatcaca      960

aacctgtgcc catttggcga ggtgttcaac gcaacccgct tcgccagcgt gtacgcctgg     1020

aataggaagc ggatcagcaa ctgcgtggcc gactatagcg tgctgtacaa ctccgcctct     1080

ttcagcacct ttaagtgcta tggcgtgtcc cccacaaagc tgaatgacct gtgctttacc     1140

aacgtctacg ccgattcttt cgtgatcagg ggcgacgagg tgcgccagat cgcccccggc     1200

cagacaggca agatcgcaga ctacaattat aagctgccag acgatttcac cggctgcgtg     1260

atcgcctgga acagcaacaa tctggattcc aaagtgggcg gcaactacaa ttatctgtac     1320

cggctgttta gaaagagcaa tctgaagccc ttcgagaggg acatctctac agaaatctac     1380

caggccggca gcaccccttg caatggcgtg gagggcttta actgttattt cccactccag     1440

tcctacggct tccagcccac aaacggcgtg ggctatcagc cttaccgcgt ggtggtgctg     1500

agctttgagc tgctgcacgc cccagcaaca gtgtgcggcc ccaagaagtc caccaatctg     1560

gtgaagaaca agtgcgtgaa cttcaacttc aacggcctga ccggcacagg cgtgctgacc     1620

gagtccaaca agaagttcct gccatttcag cagttcggca gggacatcgc agataccaca     1680

gacgccgtgc gcgacccaca gaccctggag atcctggaca tcacaccctg ctctttcggc     1740

ggcgtgagcg tgatcacacc cggcaccaat acaagcaacc aggtggccgt gctgtatcag     1800

gacgtgaatt gtaccgaggt gcccgtggct atccacgccg atcagctgac cccaacatgg     1860

cgggtgtaca gcaccggctc caacgtcttc cagacaagag ccggatgcct gatcggagca     1920

gagcacgtga acaattccta tgagtgcgac atcccaatcg gcgccggcat ctgtgcctct     1980

taccagaccc agacaaactc tcccggctcc gcctccagcg tggcctccca gtctatcatc     2040

gcctatacca tgtccctggg cgccgagaac agcgtggcct actctaacaa tagcatcgcc     2100

atcccaacca acttcacaat ctctgtgacc acagagatcc tgcccgtgtc catgaccaag     2160

acatctgtgg actgcacaat gtatatctgt ggcgattcta ccgagtgcag caacctgctg     2220

ctccagtacg gcagcttttg tacccagctg aatagagccc tgacaggcat cgccgtggag     2280

caggataaga acacacagga ggtgttcgcc caggtgaagc aaatctacaa gaccccccct     2340

atcaaggact ttggcggctt caatttttcc cagatcctgc ctgatccatc caagccttct     2400

aagcggagct ttatcgagga cctgctgttc aacaaggtga ccctggccga tgccggcttc     2460

atcaagcagt atggcgattg cctgggcgac atcgcagcca gggacctgat ctgcgcccag     2520

aagtttaatg gcctgaccgt gctgccaccc ctgctgacag atgagatgat cgcacagtac     2580

acaagcgccc tgctggccgg caccatcaca tccggatgga cctttggcgc tggcgctgct     2640

ctgcagatcc ccttcgccat gcagatggcc taccggttca acggcatcgg cgtgacccag     2700

aacgtgctgt acgagaacca gaagctgatc gccaaccagt tcaactccgc catcgggaag     2760

atccaggact ctctgtcttc taccgcttct gccctgggca agctgcagga cgtggtgaac     2820

cagaatgccc aggccctgaa caccctggtg aagcagctgt cctccaactt cggcgccatc     2880

tcctccgtgc tgaacgacat cctgtccaga ctggaccctc ctgaggccga ggtgcagatc     2940

gatcggctga tcaccggccg cctgcagtct ctgcagacct acgtgaccca gcagctgatc     3000

agagccgccg agatcagagc ctctgccaac ctcgcagcta ccaagatgtc cgagtgcgtg     3060

ctcggacagt ccaagcgggt ggacttctgc ggaaagggat accacctcat gtctttccct     3120

cagagtgctc ctcacggagt ggtgttcctc cacgtgacct acgtgcccgc tcaggagaag     3180

aacttcacca ccgctcctgc tatctgccac gacggaaagg ctcacttccc tagagaggga     3240

gtcttcgtct ccaacggaac ccactggttc gtcacccagc ggaacttcta cgagccccag     3300

atcatcacca ccgacaacac cttcgtctcc gggaactgcg acgtcgtcat cgggatcgtc     3360

aacaacaccg tctacgaccc tctgcagccc gagctcgact ccttcaagga ggagctcgac     3420

aagtacttca agaaccacac ctctcctgac gtggacctcg gggacatctc cgggatcaac     3480

gctagcgtcg tcaacatcca gaaggagatc gaccggctca acgaggtggc taagaacctc     3540

aacgagagcc tcatcgacct ccaggagctc gggaagtacg agcagtacat caaggggagc     3600

gggtacatcc ctgaggcacc tagagacggg caggcttacg tgcggaagga tggggagtgg     3660

gtcctcctca gcaccttcct c                                               3681


<210>  8
<211>  1227
<212>  PRT
<213>  Coronavirus SARS-CoV-2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1227)
<223>  Extracellular domain

<220>
<221>  MISC_FEATURE
<222>  (1)..(1227)
<223>  Spike Extracellular domain protein

<400>  8

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
                325                 330                 335     


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
            420                 425                 430         


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
        435                 440                 445             


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
    450                 455                 460                 


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
465                 470                 475                 480 


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
                485                 490                 495     


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
            500                 505                 510         


Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
        515                 520                 525             


Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys 
    530                 535                 540                 


Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr 
545                 550                 555                 560 


Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
                565                 570                 575     


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
            580                 585                 590         


Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro 
        595                 600                 605             


Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser 
    610                 615                 620                 


Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala 
625                 630                 635                 640 


Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly 
                645                 650                 655     


Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser 
            660                 665                 670         


Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala 
        675                 680                 685             


Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn 
    690                 695                 700                 


Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys 
705                 710                 715                 720 


Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys 
                725                 730                 735     


Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg 
            740                 745                 750         


Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val 
        755                 760                 765             


Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe 
    770                 775                 780                 


Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser 
785                 790                 795                 800 


Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala 
                805                 810                 815     


Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala 
            820                 825                 830         


Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu 
        835                 840                 845             


Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu 
    850                 855                 860                 


Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala 
865                 870                 875                 880 


Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile 
                885                 890                 895     


Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn 
            900                 905                 910         


Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr 
        915                 920                 925             


Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln 
    930                 935                 940                 


Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile 
945                 950                 955                 960 


Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala 
                965                 970                 975     


Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln 
            980                 985                 990         


Thr Tyr Val Thr Gln Gln Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser 
        995                 1000                 1005             


Ala Asn  Leu Ala Ala Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln 
    1010                 1015                 1020             


Ser Lys  Arg Val Asp Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser 
    1025                 1030                 1035             


Phe Pro  Gln Ser Ala Pro His  Gly Val Val Phe Leu  His Val Thr 
    1040                 1045                 1050             


Tyr Val  Pro Ala Gln Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile 
    1055                 1060                 1065             


Cys His  Asp Gly Lys Ala His  Phe Pro Arg Glu Gly  Val Phe Val 
    1070                 1075                 1080             


Ser Asn  Gly Thr His Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu 
    1085                 1090                 1095             


Pro Gln  Ile Ile Thr Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys 
    1100                 1105                 1110             


Asp Val  Val Ile Gly Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu 
    1115                 1120                 1125             


Gln Pro  Glu Leu Asp Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe 
    1130                 1135                 1140             


Lys Asn  His Thr Ser Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly 
    1145                 1150                 1155             


Ile Asn  Ala Ser Val Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu 
    1160                 1165                 1170             


Asn Glu  Val Ala Lys Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln 
    1175                 1180                 1185             


Glu Leu  Gly Lys Tyr Glu Gln  Tyr Ile Lys Gly Ser  Gly Tyr Ile 
    1190                 1195                 1200             


Pro Glu  Ala Pro Arg Asp Gly  Gln Ala Tyr Val Arg  Lys Asp Gly 
    1205                 1210                 1215             


Glu Trp  Val Leu Leu Ser Thr  Phe Leu 
    1220                 1225         


<210>  9
<211>  43
<212>  DNA
<213>  artificial sequence

<220>
<223>  chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  scFv_hVHF1 Forward primer

<400>  9
gtgaccacag gcgtccacag cgargtgcag ctggtgsagt cyg                         43


<210>  10
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically syntesized


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  scFv_hVHF3 Forward primer

<400>  10
gtgaccacag gcgtccacag ccaggtgcag ctgcaggast ygg                         43


<210>  11
<211>  42
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  scFv_hVHF4 Forward primer

<400>  11
gtgaccacag gcgtccacag ccaggtgcag ctacarcagt gg                          42


<210>  12
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  scFv_hVHF5 Forward primer

<400>  12
gtgaccacag gcgtccacag ccagstgcag ctrcaggagt csg                         43


<210>  13
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  scFv_hVHF6 Forward primer

<400>  13
gtgaccacag gcgtccacag ccaggthcag ctkgtgsagt ctg                         43


<210>  14
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  scFv_hVHF9 Forward primer

<400>  14
gtgaccacag gcgtccacag cgaggtgcar ctggtggagt cyg                         43


<210>  15
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  scFv_hVHF10 Forward primer

<400>  15
gtgaccacag gcgtccacag ccaggtrcag ctgcagsagt crg                         43


<210>  16
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  scFv_hVHF13 Forward primer

<400>  16
gtgaccacag gcgtccacag ccaggtgcag ctgktggast ctg                         43


<210>  17
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  scFv_hVHF14 Forward primer

<400>  17
gtgaccacag gcgtccacag cgaggtgcag ctgktggagw ctg                         43


<210>  18
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  scFv_hVHF2 Forward primer

<400>  18
gtgaccacag gcgtccacag ccagrtcacc ttgarggagt ctg                         43


<210>  19
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  scFv_hVHF7 Forward primer

<400>  19
gtgaccacag gcgtccacag ccaggtscag ctggtgcaat ctg                         43


<210>  20
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  scFv_hVHF8 Forward primer

<400>  20
gtgaccacag gcgtccacag ccagrtgcag ctggtgcagt ctg                         43


<210>  21
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  scFv_hVHF11 Forward primer

<400>  21
gtgaccacag gcgtccacag csaggtccag ctggtacagt ctg                         43


<210>  22
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  scFv_hVHF12 Forward primer

<400>  22
gtgaccacag gcgtccacag ccaaatgcag ctggtgcagt ctg                         43


<210>  23
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  hiLIC_IgG VH reverse primer (5'-3')

<400>  23
gggaagaccg atgggccctt g                                                 21


<210>  24
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  VL kappa forward primer hiLIC_VK1

<400>  24
ggctgacaga cgccaggtgc gaaatagtga tgacgcagtc tcc                         43


<210>  25
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  VL kappa forward primer hiLIC_VK2

<400>  25
ggctgacaga cgccaggtgc gakattgtga tgacccagac tcc                         43


<210>  26
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  VL kappa forward primer hiLIC_VK3

<400>  26
ggctgacaga cgccaggtgc racatccaga tgacccagtc tcc                         43


<210>  27
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  VL kappa forward primer hiLIC_VK4

<400>  27
ggctgacaga cgccaggtgc gycatcygga tgacccagtc tcc                         43


<210>  28
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  VL kappa forward primer hiLIC_VK5

<400>  28
ggctgacaga cgccaggtgc gacatcgtga tgacccagtc tcc                         43


<210>  29
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  VL kappa forward primer hiLIC_VK6

<400>  29
ggctgacaga cgccaggtgc gaaattgtgy tgacdcagtc tcc                         43


<210>  30
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  VL kappa forward primer hiLIC_VK7

<400>  30
ggctgacaga cgccaggtgc gaaacgacac tcacgcagtc tcc                         43


<210>  31
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  VL kappa forward primer hiLIC_VK8

<400>  31
ggctgacaga cgccaggtgc gatrttgtga tgactcagtc tcc                         43


<210>  32
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  VL kappa forward primer hiLIC_VK9

<400>  32
ggctgacaga cgccaggtgc gmcatccagw tgacccagtc tcc                         43


<210>  33
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  VL kappa forward primer hiLIC_VK10

<400>  33
ggctgacaga cgccaggtgc gaaattgtaa tgacacagtc tcc                         43


<210>  34
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(24)
<223>  VL kappa reverse primer

<400>  34
tgaagacaga tggtgcagcc acag                                              24


<210>  35
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(40)
<223>  VL lambda forward primer hiLIC_VL1

<400>  35
ggctgacaga cgccaggtgc cagtctgtgy tgackcagcc                             40


<210>  36
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(40)
<223>  VL lambda forward primer hiLIC_VL2

<400>  36
ggctgacaga cgccaggtgc cagtctgtcg tgacgcagcc                             40


<210>  37
<211>  41
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(41)
<223>  VL lambda forward primer hiLIC_VL3

<400>  37
ggctgacaga cgccaggtgc cagtctgccc tgactcagcc t                           41


<210>  38
<211>  42
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  VL lambda forward primer hiLIC_VL9

<400>  38
ggctgacaga cgccaggtgc tcctatgwgc tgacwcagcy ac                          42


<210>  39
<211>  42
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  VL lambda forward primer hiLIC_VL10

<400>  39
ggctgacaga cgccaggtgc tcctatgagc tgatgcagcc ac                          42


<210>  40
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  VL lambda forward primer hiLIC_VL11

<400>  40
ggctgacaga cgccaggtgc tcctatgagc tgacacagcc atc                         43


<210>  41
<211>  42
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  VL lambda forward primer hiLIC_VL12

<400>  41
ggctgacaga cgccaggtgc tcttctgagc tgactcagga cc                          42


<210>  42
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(23)
<223>  VL lambda reverse primer hiLIC_CL

<400>  42
accagtgtgg ccttgttggc ttg                                               23


<210>  43
<211>  366
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(366)
<223>  23G7 hIgG VH

<400>  43
gaggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc ggctactatt tccactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaacccta tcagtggtgg cacaaagtat      180

gcacagaagt ttcaggggtg ggtcaccatg accagggcca cgtccatcag cacagtctac      240

atggaggtga gcaggctgag atctgacgac acggccgtgt attactgtgc gagaggacac      300

acgtataact ggaactacgc ctactgtgac tactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  44
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  MISC_FEATURE
<223>  23G7 hIgG VH protein

<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  23G7 hIgG VH protein

<400>  44

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Phe His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Ile Ser Gly Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Trp Val Thr Met Thr Arg Ala Thr Ser Ile Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Val Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His Thr Tyr Asn Trp Asn Tyr Ala Tyr Cys Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  45
<211>  1356
<212>  DNA
<213>  Artificial sequence

<220>
<223>  chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(1356)
<223>  23G7 hIgG Heavy Chain DNA

<400>  45
gaggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc ggctactatt tccactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaacccta tcagtggtgg cacaaagtat      180

gcacagaagt ttcaggggtg ggtcaccatg accagggcca cgtccatcag cacagtctac      240

atggaggtga gcaggctgag atctgacgac acggccgtgt attactgtgc gagaggacac      300

acgtataact ggaactacgc ctactgtgac tactggggcc agggaaccct ggtcaccgtc      360

tcctcagcct ccaccaaggg cccatcggtc ttccctctgg cccccagcag caagtctacc      420

agcggcggaa cagccgccct gggctgcctg gtcaaggact acttccccga gcccgtgacc      480

gtgtcctgga acagcggagc cctgacaagc ggagtgcaca ccttccctgc cgtgctgcag      540

tccagcggcc tgtatagcct gagcagcgtc gtgaccgtgc ctagcagcag cctgggcacc      600

cagacctaca tctgcaacgt gaaccacaag cccagcaaca ccaaggtgga caagaaggtg      660

gagcccaaga gctgcgacaa gacccatacc tgcccccctt gtcctgcccc tgagctgctg      720

ggcggaccca gcgtgtttct gttccccccc aagcccaagg acaccctgat gatcagccgg      780

acccccgaag tgacctgcgt ggtggtggat gtgtcccacg aggaccctga agtgaagttc      840

aattggtacg tggacggcgt ggaggtgcac aacgccaaga ccaagccccg ggaggaacag      900

tacaacagca cctaccgggt ggtgtccgtg ctgaccgtgc tgcaccagga ctggctgaac      960

ggcaaagaat acaagtgcaa ggtgtccaac aaggccctgc ctgcccccat cgagaaaacc     1020

atcagcaagg ccaagggcca gcccagagaa ccccaggtgt acaccctgcc tcccagcaga     1080

gatgagctga ccaagaacca ggtgtccctg acctgcctcg tgaagggctt ctacccctcc     1140

gatatcgccg tggagtggga gagcaacggc cagcctgaga acaactacaa gaccaccccc     1200

cctgtgctgg atagcgacgg cagcttcttc ctgtacagca agctgaccgt ggacaagagc     1260

agatggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1320

tacacccaga agtccctgag cctgagcccc ggcaag                               1356


<210>  46
<211>  452
<212>  PRT
<213>  artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  METAL
<222>  (1)..(452)
<223>  23G7 hIgG Heavy Chain protein

<400>  46

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Phe His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Ile Ser Gly Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Trp Val Thr Met Thr Arg Ala Thr Ser Ile Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Val Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His Thr Tyr Asn Trp Asn Tyr Ala Tyr Cys Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  47
<211>  330
<212>  DNA
<213>  artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(330)
<223>  23G7 hIgG VL DNA

<400>  47
tcctatgtgc tgacacagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttggt gtttataact atgtctcctg gtaccaacaa      120

cacccaggca aagcccccaa actcatgatt tatgatgtca gtaatcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatata caagcagcag cactctggta      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210>  48
<211>  110
<212>  PRT
<213>  artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(110)
<223>  23G7 hIgG VL protein

<400>  48

Ser Tyr Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Val Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  49
<211>  648
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(648)
<223>  23G7 hIgG LC DNA

<400>  49
tcctatgtgc tgacacagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttggt gtttataact atgtctcctg gtaccaacaa      120

cacccaggca aagcccccaa actcatgatt tatgatgtca gtaatcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatata caagcagcag cactctggta      300

ttcggcggag ggaccaagct gaccgtccta ggtcagccca aggctgcccc ctcggtcact      360

ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt ctgcctgatc      420

tccgacttct accctggcgc cgtgaccgtg gcctggaagg ccgattccag ccctgtgaag      480

gccggcgtgg aaaccaccac cccctccaag cagtccaaca acaaatacgc cgcctcctcc      540

tacctgtccc tgacccccga gcagtggaag tcccacagat cctacagctg ccaggtcaca      600

cacgagggct ccaccgtgga aaagaccgtg gcccctaccg agtgctcc                   648


<210>  50
<211>  216
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(216)
<223>  23G7 hIG LC protein

<400>  50

Ser Tyr Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Val Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  51
<211>  1425
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(1425)
<223>  23G7.1 hIgA1 heavy chain cDNA

<400>  51
caggtgcagc tggtgcagtc tggcgctgag gtgaagaagc ctggcgcctc tgtgaaggtg       60

tcctgcaagg cctccggcta taccttcacc ggctactact tccactgggt gagacaagct      120

cctggacagg gcctggagtg gatgggctgg atcaacccca tcagcggcgg caccaagtac      180

gcccagaagt tccagggctg ggtgaccatg acccgggcta ccagcatcag caccgtgtac      240

atggaggtgt ctcggctgcg gtctgacgac accgctgtgt actactgcgc tcggggacac      300

acctacaact ggaactacgc ctactgcgac tactggggac agggaacact ggtgaccgtg      360

tcttccgctt cgccaacgtc tccaaaggtg ttcccactgt ctctgtgctc tacccagccc      420

gacggcaacg tggtgatcgc ctgcctggtg cagggcttct tccctcagga gcccctgtcc      480

gtgacctgga gcgagtctgg ccagggcgtg accgctcgga acttccctcc ttctcaggac      540

gcctctggcg acctgtacac caccagctcc cagctgaccc tgcctgctac ccagtgtctc      600

gctggcaagt ctgtgacatg ccacgtgaag cactacacca acccctctca ggacgtgacc      660

gtgccttgcc ctgtgccttc tacccctcct accccatctc catcgacacc accaacccct      720

tctccctctt gctgccaccc cagactgtct ctgcacagac ctgctctgga ggacctgctg      780

ctgggctctg aggccaacct gacctgcacc ctgaccggac tgagagacgc ttctggagtg      840

accttcacct ggaccccatc ctctggaaag tctgcagtcc agggacctcc tgagagagac      900

ctgtgcggat gctactccgt ctcttctgtc ctccctggat gcgctgagcc ttggaaccac      960

ggaaagacct tcacatgcac cgccgcctac cctgagtcta agaccccact caccgccacc     1020

ctctctaaga gcgggaacac cttcagacct gaggtccacc tgctcccacc tccatctgag     1080

gagctcgccc tcaacgagct ggtcaccctc acctgcctgg cccgtgggtt ctccccaaag     1140

gacgtcctcg tcagatggct ccaggggagt caggagctgc ccagagagaa gtacctcacc     1200

tgggcctcta gacaggagcc cagtcagggg accaccacct tcgctgtcac ctctatcctc     1260

cgggtcgctg ccgaagactg gaagaaggga gacaccttct cctgcatggt cgggcacgag     1320

gctctgcctc tcgctttcac ccagaagacc atcgacagac tcgccgggaa gcctacccac     1380

gtcaacgtct ctgtcgtcat ggctgaggtc gacgggacct gctac                     1425


<210>  52
<211>  1386
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(1386)
<223>  23G7.1hIgA2m1 heavy chain cDNA

<400>  52
caggtgcagc tggtgcagtc tggcgctgag gtgaagaagc ctggcgcctc tgtgaaggtg       60

tcctgcaagg cctccggcta taccttcacc ggctactact tccactgggt gagacaagct      120

cctggacagg gcctggagtg gatgggctgg atcaacccca tcagcggcgg caccaagtac      180

gcccagaagt tccagggctg ggtgaccatg acccgggcta ccagcatcag caccgtgtac      240

atggaggtgt ctcggctgcg gtctgacgac accgctgtgt actactgcgc tcggggacac      300

acctacaact ggaactacgc ctactgcgac tactggggac agggaacact ggtgaccgtg      360

tcttccgctt cgccaacgtc tccaaaggtg ttcccactgt ctctggactc tacccctcag      420

gacggcaacg tggtggtggc ttgcctggtg cagggcttct tccctcagga gcccctgtct      480

gtgacctggt ctgagtccgg ccagaacgtg accgcccgga acttccctcc ttctcaggac      540

gcctctggcg acctgtacac cacaagctcc cagctgaccc tgcctgctac ccagtgtcca      600

gacggcaagt ccgtgacctg ccacgtgaag cactacacca acccgtccca ggacgtgacc      660

gtgccttgcc ctgtgccccc acctccccca tgctgccacc ctagactgtc tctgcacaga      720

cctgctctgg aggacctgct gctgggctct gaggccaacc tgacctgcac cctgaccggg      780

ctgagagacg cttctggagc taccttcacc tggaccccat cctctggaaa gtctgctgtc      840

cagggacctc ctgagagaga cctgtgcgga tgctactccg tctcttctgt cctccctgga      900

tgcgctcagc cttggaacca cggagagacc ttcacctgca ccgctgccca ccctgagctc      960

aagacccctc tcaccgccaa catcaccaag tccggcaaca ccttcagacc tgaggtccac     1020

ctgctgcctc ccccttctga ggagctcgcc ctcaacgagc tggtcaccct cacctgcctg     1080

gcccgtgggt tctccccaaa ggacgtcctc gtcagatggc tccaggggtc tcaggagctg     1140

cccagagaga agtacctcac ctgggcctct agacaggagc ccagtcaggg gaccaccacc     1200

ttcgctgtca cctctatcct ccgggtcgct gccgaagact ggaagaaggg agacaccttc     1260

tcctgcatgg tcgggcacga ggctctgccc ctcgctttca cccagaagac catcgaccgg     1320

atggccggga agcctaccca cgtcaacgtc tctgtcgtca tggctgaggt cgacgggacc     1380

tgctac                                                                1386


<210>  53
<211>  1386
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(1386)
<223>  23G7.1 hIgA2m2 heavy chaing cDNA

<400>  53
caggtgcagc tggtgcagtc tggcgctgag gtgaagaagc ctggcgcctc tgtgaaggtg       60

tcctgcaagg cctccggcta taccttcacc ggctactact tccactgggt gagacaagct      120

cctggacagg gcctggagtg gatgggctgg atcaacccca tcagcggcgg caccaagtac      180

gcccagaagt tccagggctg ggtgaccatg acccgggcta ccagcatcag caccgtgtac      240

atggaggtgt ctcggctgcg gtctgacgac accgctgtgt actactgcgc tcggggacac      300

acctacaact ggaactacgc ctactgcgac tactggggac agggaacact ggtgaccgtg      360

tcttccgctt cgccaacgtc tccaaaggtg ttcccactgt ctctggactc tacccctcag      420

gacggcaacg tggtggtggc ttgcctggtg cagggcttct tccctcagga gcccctgtct      480

gtgacctggt ctgagtccgg ccagaacgtg accgcccgga acttccctcc ttctcaggac      540

gcctctggcg acctgtacac cacaagctcc cagctgaccc tgcctgctac ccagtgtcca      600

gacggcaagt ccgtgacctg ccacgtgaag cactacacca actcctccca ggacgtgacc      660

gtgccttgca gagtgccccc acctccccca tgctgccacc ctagactgtc tctgcacaga      720

cctgctctgg aggacctgct gctgggctct gaggccaacc tgacctgcac cctgaccggg      780

ctgagagacg cttctggagc taccttcacc tggaccccat cctctggaaa gtctgctgtc      840

cagggacctc ctgagagaga cctgtgcgga tgctactccg tctcttctgt cctccctgga      900

tgcgctcagc cttggaacca cggagagacc ttcacctgca ccgctgccca ccctgagctc      960

aagacccctc tcaccgccaa catcaccaag tccggcaaca ccttcagacc tgaggtccac     1020

ctgctgcctc ccccttctga ggagctcgcc ctcaacgagc tggtcaccct cacctgcctg     1080

gcccgtgggt tctccccaaa ggacgtcctc gtcagatggc tccaggggtc tcaggagctg     1140

cccagagaga agtacctcac ctgggcctct agacaggagc ccagtcaggg gaccaccacc     1200

tacgctgtca cctctatcct ccgggtcgct gccgaagact ggaagaaggg agagaccttc     1260

tcctgcatgg tcgggcacga ggctctgccc ctcgctttca cccagaagac catcgaccgg     1320

atggccggga agcctaccca catcaacgtc tctgtcgtca tggctgaggc cgacgggacc     1380

tgctac                                                                1386


<210>  54
<211>  648
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(648)
<223>  23G7.1 lambda light chain cDNA

<400>  54
cagtctgccc tgacccagcc tgcctctgtg tctggctctc ccggccagtc tatcaccatc       60

tcttgcaccg gcacctcttc cgacgtgggc gtgtacaact acgtgtcctg gtaccagcag      120

caccctggaa aggccccaaa gctgatgatc tacgacgtgt ctaaccggcc ctctggagtg      180

tccaatcggt tctccggatc taagtccgga aacaccgcct ccctgaccat ctctgggctg      240

caggctgagg acgaggctga ctactactgc tcctcctaca ccagctcctc caccctcgtg      300

ttcggaggag ggacaaagct cacagtcctc ggccagccta aggccgctcc ttccgtgacc      360

ctgttccccc cttcctccga ggagctgcag gccaacaagg ccaccctggt gtgcctgatc      420

tccgacttct accctggcgc cgtgaccgtg gcttggaagg ctgactcctc ccccgtgaag      480

gctggcgtgg agaccaccac cccctccaag cagtccaaca acaagtacgc cgcctcctcc      540

tacctgagcc tgacccctga gcagtggaag tcccacaggt cctacagctg ccaggtgacc      600

cacgagggct ccaccgtgga gaagaccgtg gcccctaccg agtgctcc                   648


<210>  55
<211>  475
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(475)
<223>  23G7.1 hIgA1 heavy chain protein

<400>  55

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Phe His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Ile Ser Gly Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Trp Val Thr Met Thr Arg Ala Thr Ser Ile Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Val Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His Thr Tyr Asn Trp Asn Tyr Ala Tyr Cys Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Pro Thr Ser Pro 
        115                 120                 125             


Lys Val Phe Pro Leu Ser Leu Cys Ser Thr Gln Pro Asp Gly Asn Val 
    130                 135                 140                 


Val Ile Ala Cys Leu Val Gln Gly Phe Phe Pro Gln Glu Pro Leu Ser 
145                 150                 155                 160 


Val Thr Trp Ser Glu Ser Gly Gln Gly Val Thr Ala Arg Asn Phe Pro 
                165                 170                 175     


Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr Thr Thr Ser Ser Gln Leu 
            180                 185                 190         


Thr Leu Pro Ala Thr Gln Cys Leu Ala Gly Lys Ser Val Thr Cys His 
        195                 200                 205             


Val Lys His Tyr Thr Asn Pro Ser Gln Asp Val Thr Val Pro Cys Pro 
    210                 215                 220                 


Val Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr Pro 
225                 230                 235                 240 


Ser Pro Ser Cys Cys His Pro Arg Leu Ser Leu His Arg Pro Ala Leu 
                245                 250                 255     


Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys Thr Leu Thr 
            260                 265                 270         


Gly Leu Arg Asp Ala Ser Gly Val Thr Phe Thr Trp Thr Pro Ser Ser 
        275                 280                 285             


Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp Leu Cys Gly Cys 
    290                 295                 300                 


Tyr Ser Val Ser Ser Val Leu Pro Gly Cys Ala Glu Pro Trp Asn His 
305                 310                 315                 320 


Gly Lys Thr Phe Thr Cys Thr Ala Ala Tyr Pro Glu Ser Lys Thr Pro 
                325                 330                 335     


Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe Arg Pro Glu Val 
            340                 345                 350         


His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn Glu Leu Val 
        355                 360                 365             


Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser Pro Lys Asp Val Leu Val 
    370                 375                 380                 


Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys Tyr Leu Thr 
385                 390                 395                 400 


Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr Thr Phe Ala Val 
                405                 410                 415     


Thr Ser Ile Leu Arg Val Ala Ala Glu Asp Trp Lys Lys Gly Asp Thr 
            420                 425                 430         


Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu Ala Phe Thr Gln 
        435                 440                 445             


Lys Thr Ile Asp Arg Leu Ala Gly Lys Pro Thr His Val Asn Val Ser 
    450                 455                 460                 


Val Val Met Ala Glu Val Asp Gly Thr Cys Tyr 
465                 470                 475 


<210>  56
<211>  462
<212>  PRT
<213>  Artificial sequence

<220>
<223>  chemically synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(462)
<223>  23G7.1 hIgA2m1 heavy chain protein

<400>  56

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Phe His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Ile Ser Gly Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Trp Val Thr Met Thr Arg Ala Thr Ser Ile Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Val Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His Thr Tyr Asn Trp Asn Tyr Ala Tyr Cys Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Pro Thr Ser Pro 
        115                 120                 125             


Lys Val Phe Pro Leu Ser Leu Asp Ser Thr Pro Gln Asp Gly Asn Val 
    130                 135                 140                 


Val Val Ala Cys Leu Val Gln Gly Phe Phe Pro Gln Glu Pro Leu Ser 
145                 150                 155                 160 


Val Thr Trp Ser Glu Ser Gly Gln Asn Val Thr Ala Arg Asn Phe Pro 
                165                 170                 175     


Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr Thr Thr Ser Ser Gln Leu 
            180                 185                 190         


Thr Leu Pro Ala Thr Gln Cys Pro Asp Gly Lys Ser Val Thr Cys His 
        195                 200                 205             


Val Lys His Tyr Thr Asn Pro Ser Gln Asp Val Thr Val Pro Cys Pro 
    210                 215                 220                 


Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His Arg 
225                 230                 235                 240 


Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys 
                245                 250                 255     


Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp Thr 
            260                 265                 270         


Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp Leu 
        275                 280                 285             


Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Cys Ala Gln Pro 
    290                 295                 300                 


Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu Leu 
305                 310                 315                 320 


Lys Thr Pro Leu Thr Ala Asn Ile Thr Lys Ser Gly Asn Thr Phe Arg 
                325                 330                 335     


Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn 
            340                 345                 350         


Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser Pro Lys Asp 
        355                 360                 365             


Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys 
    370                 375                 380                 


Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr Thr 
385                 390                 395                 400 


Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp Trp Lys Lys 
                405                 410                 415     


Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu Ala 
            420                 425                 430         


Phe Thr Gln Lys Thr Ile Asp Arg Met Ala Gly Lys Pro Thr His Val 
        435                 440                 445             


Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys Tyr 
    450                 455                 460         


<210>  57
<211>  462
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(462)
<223>  23G7.1 hIgA2m2 heavy chain protein

<400>  57

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Phe His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Ile Ser Gly Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Trp Val Thr Met Thr Arg Ala Thr Ser Ile Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Val Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His Thr Tyr Asn Trp Asn Tyr Ala Tyr Cys Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Pro Thr Ser Pro 
        115                 120                 125             


Lys Val Phe Pro Leu Ser Leu Asp Ser Thr Pro Gln Asp Gly Asn Val 
    130                 135                 140                 


Val Val Ala Cys Leu Val Gln Gly Phe Phe Pro Gln Glu Pro Leu Ser 
145                 150                 155                 160 


Val Thr Trp Ser Glu Ser Gly Gln Asn Val Thr Ala Arg Asn Phe Pro 
                165                 170                 175     


Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr Thr Thr Ser Ser Gln Leu 
            180                 185                 190         


Thr Leu Pro Ala Thr Gln Cys Pro Asp Gly Lys Ser Val Thr Cys His 
        195                 200                 205             


Val Lys His Tyr Thr Asn Ser Ser Gln Asp Val Thr Val Pro Cys Arg 
    210                 215                 220                 


Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His Arg 
225                 230                 235                 240 


Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys 
                245                 250                 255     


Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp Thr 
            260                 265                 270         


Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp Leu 
        275                 280                 285             


Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Cys Ala Gln Pro 
    290                 295                 300                 


Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu Leu 
305                 310                 315                 320 


Lys Thr Pro Leu Thr Ala Asn Ile Thr Lys Ser Gly Asn Thr Phe Arg 
                325                 330                 335     


Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn 
            340                 345                 350         


Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser Pro Lys Asp 
        355                 360                 365             


Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys 
    370                 375                 380                 


Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr Thr 
385                 390                 395                 400 


Tyr Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp Trp Lys Lys 
                405                 410                 415     


Gly Glu Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu Ala 
            420                 425                 430         


Phe Thr Gln Lys Thr Ile Asp Arg Met Ala Gly Lys Pro Thr His Ile 
        435                 440                 445             


Asn Val Ser Val Val Met Ala Glu Ala Asp Gly Thr Cys Tyr 
    450                 455                 460         


<210>  58
<211>  216
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(216)
<223>  23G7.1 lambda light chain protein

<400>  58

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Val Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  59
<211>  348
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(348)
<223>  23E2 hIgG VH DNA

<400>  59
cagatgcagc tggtgcagtc tggaggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctgggtt caccgtcagt agcaactaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagtt atttatagcg gtggtagcac attctacgca      180

gactccgtga agggccgatt caccatctcc agacacaatt ccaagaacac gctgtatctt      240

caaatgaaca gcctgagagc tgaggacacg gccgtgtatt actgtgcgag aggcttagcc      300

gatgtttttg atatctgggg ccaagggaca atggtcaccg tctcttca                   348


<210>  60
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(116)
<223>  23E2 hIgG VH protein

<400>  60

Gln Met Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg His Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Leu Ala Asp Val Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  61
<211>  324
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(324)
<223>  23E2 hIG VL DNA

<400>  61
gacatccaga tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gggcattagc aattatttag cctggtatca gcaaaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccactt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag cttaatagtt accctgggct cactttcggc      300

ggagggacca aggtggagat caaa                                             324


<210>  62
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(108)
<223>  23hIgG VL protein

<400>  62

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Gly 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  63
<211>  357
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(357)
<223>  42B7 hIgG VH DNA

<400>  63
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggaat catcgtcagt ttcaactaca tgacctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaatt atttatagcg gtggtagtac attctacgca      180

gactccgtga agggccgatt caccatctcc agagaccatt ccaagaacac actgtatctt      240

caaatgaaca gcctgagagc tgaggacacg gctatttatt actgtgcgag agtcctaccc      300

cagggggact actttgacta ctggggccag ggaaccctgg tcaccgtctc ctcaacc         357


<210>  64
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(119)
<223>  42B7 hIgG VH protein

<400>  64

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Ile Val Ser Phe Asn 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ile Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp His Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Leu Pro Gln Gly Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Thr 
        115                 


<210>  65
<211>  321
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  42B7 hIgG VL

<400>  65
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctcacac tttcggccct      300

gggaccaaag tggatatcaa a                                                321


<210>  66
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  chemically synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  42B7 hIgG VL protein

<400>  66

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro His 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  67
<211>  384
<212>  DNA
<213>  artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(384)
<223>  8A12 hIgG VH DNA

<400>  67
gaggtgcagc tgcaggagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg tttccggata caccctcact gaattatcca tgcactgggt gcgacaggct      120

cctggaaaag ggcttgagtg gatgggaggt tttgatcctg aagatggtga aacaatctac      180

gcacagaagt tccagggcag agtcaccatg accgaggaca catctacaga cacagcctat      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgt aacagcccac      300

cctataactg gaacgcccaa cgactactac tactactacg gtatggacgt ctggggccaa      360

gggaccacgg tcaccgtctc ctca                                             384


<210>  68
<211>  128
<212>  PRT
<213>  artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(128)
<223>  8A12 hIgG VH protein

<400>  68

Glu Val Gln Leu Gln Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Thr Ala His Pro Ile Thr Gly Thr Pro Asn Asp Tyr Tyr Tyr Tyr 
            100                 105                 110         


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  69
<211>  336
<212>  DNA
<213>  artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(336)
<223>  8A12 hIgG VL DNA

<400>  69
gatattgtga tgacccagac tccactctcc tcacctgtca cccttggaca gccggcctcc       60

atctcctgca ggtctagtca aagtctcgta cacagtgatg gaaacaccta cttgagttgg      120

cttcagcaga ggccaggcca gcctccaaga ctcctaattt ataagatttc taaccgcttc      180

tctggggtcc cagacagatt cagtggcagt ggggcaggga cagatttcac actgaaaatc      240

agcagggtgg aaggtgagga tgtcggggtt tattactgca tgcaagctac acaattcccg      300

tacacttttg gccaggggac caagctggag atcaaa                                336


<210>  70
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  chemically synthesized


<220>
<221>  METAL
<222>  (1)..(112)
<223>  8A12 hIgG VL protein

<400>  70

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Ser Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ser Trp Leu Gln Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Gly Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Thr Gln Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  71
<211>  366
<212>  DNA
<213>  artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(366)
<223>  23G7.1 VH DNA

<400>  71
caggtgcagc tggtgcagtc tggcgctgag gtgaagaagc ctggcgcctc tgtgaaggtg       60

tcctgcaagg cctccggcta taccttcacc ggctactact tccactgggt gagacaagct      120

cctggacagg gcctggagtg gatgggctgg atcaacccca tcagcggcgg caccaagtac      180

gcccagaagt tccagggctg ggtgaccatg acccgggcta ccagcatcag caccgtgtac      240

atggaggtgt ctcggctgcg gtctgacgac accgctgtgt actactgcgc tcggggacac      300

acctacaact ggaactacgc ctactgcgac tactggggac agggaacact ggtgaccgtg      360

tcttcc                                                                 366


<210>  72
<211>  122
<212>  PRT
<213>  artificial sequence

<220>
<223>  chemically synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  23G7.1 VH protein

<400>  72

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Phe His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Ile Ser Gly Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Trp Val Thr Met Thr Arg Ala Thr Ser Ile Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Val Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His Thr Tyr Asn Trp Asn Tyr Ala Tyr Cys Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  73
<211>  330
<212>  DNA
<213>  artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(330)
<223>  23G7.1 VL DNA

<400>  73
cagtctgccc tgacccagcc tgcctctgtg tctggctctc ccggccagtc tatcaccatc       60

tcttgcaccg gcacctcttc cgacgtgggc gtgtacaact acgtgtcctg gtaccagcag      120

caccctggaa aggccccaaa gctgatgatc tacgacgtgt ctaaccggcc ctctggagtg      180

tccaatcggt tctccggatc taagtccgga aacaccgcct ccctgaccat ctctgggctg      240

caggctgagg acgaggctga ctactactgc tcctcctaca ccagctcctc caccctcgtg      300

ttcggaggag ggacaaagct cacagtcctc                                       330


<210>  74
<211>  110
<212>  PRT
<213>  artificial sequence

<220>
<223>  chemically synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(110)
<223>  23G7.1 VL protein

<400>  74

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Val Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  75
<211>  527
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  promoter
<222>  (1)..(527)
<223>  RSV LTR promoter

<400>  75
ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg cgagcaaaat ttaagctaca       60

acaaggcaag gcttgaccga caattgcatg aagaatctgc ttagggttag gcgttttgcg      120

ctgcttcgcg atgtacgggc cagatatacg cgtatctgag gggactaggg tgtgtttagg      180

cgaaaagcgg ggcttcggtt gtacgcggtt aggagtcccc tcaggatata gtagtttcgc      240

ttttgcatag ggagggggaa atgtagtctt atgcaatact cttgtagtct tgcaacatgg      300

taacgatgag ttagcaacat gccttacaag gagagaaaaa gcaccgtgca tgccgattgg      360

tggaagtaag gtggtacgat cgtgccttat taggaaggca acagacgggt ctgacatgga      420

ttggacgaac cactgaattc cgcattgcag agatattgta tttaagtgcc tagctcgata      480

caataaacgc catttgacca ttcaccacat tggtgtgcac ctccaag                    527


<210>  76
<211>  194
<212>  DNA
<213>  Artificial sequence

<220>
<223>  chemically syntesized


<220>
<221>  Intron
<222>  (1)..(194)

<220>
<221>  Intron
<222>  (1)..(194)
<223>  synthetic 5' intron

<400>  76
gtaagtggcg tttctcgggg agccagctgc gtccgctgtc gtgctgtcgg tgtagtacta       60

gcaagcgtta agtccccatc tggctgcggc ctaccgaaga gtggtcttca cgtcacacgc      120

tgtcccacgc acgtggttgg tttggtcgct tctggttact gactactaag cagccttttc      180

ttttttcctt tcag                                                        194


<210>  77
<211>  57
<212>  DNA
<213>  artificial sequence

<220>
<223>  chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(57)
<223>  Immunoglobulin heavy chain secretion leader peptide cDNA

<400>  77
atggagtggt cttgggtgtt cctgttcttt ctgtccgtga ccacaggcgt ccacagc          57


<210>  78
<211>  996
<212>  DNA
<213>  artificial sequence

<220>
<223>  chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(996)
<223>  human IgG1 constant domain cDNA

<400>  78
gcctccacca agggcccatc ggtcttccct ctggccccca gcagcaagtc taccagcggc       60

ggaacagccg ccctgggctg cctggtcaag gactacttcc ccgagcccgt gaccgtgtcc      120

tggaacagcg gagccctgac aagcggagtg cacaccttcc ctgccgtgct gcagtccagc      180

ggcctgtata gcctgagcag cgtcgtgacc gtgcctagca gcagcctggg cacccagacc      240

tacatctgca acgtgaacca caagcccagc aacaccaagg tggacaagaa ggtggagccc      300

aagagctgcg acaagaccca tacctgcccc ccttgtcctg cccctgagct gctgggcgga      360

cccagcgtgt ttctgttccc ccccaagccc aaggacaccc tgatgatcag ccggaccccc      420

gaagtgacct gcgtggtggt ggatgtgtcc cacgaggacc ctgaagtgaa gttcaattgg      480

tacgtggacg gcgtggaggt gcacaacgcc aagaccaagc cccgggagga acagtacaac      540

agcacctacc gggtggtgtc cgtgctgacc gtgctgcacc aggactggct gaacggcaaa      600

gaatacaagt gcaaggtgtc caacaaggcc ctgcctgccc ccatcgagaa aaccatcagc      660

aaggccaagg gccagcccag agaaccccag gtgtacaccc tgcctcccag cagagatgag      720

ctgaccaaga accaggtgtc cctgacctgc ctcgtgaagg gcttctaccc ctccgatatc      780

gccgtggagt gggagagcaa cggccagcct gagaacaact acaagaccac cccccctgtg      840

ctggatagcg acggcagctt cttcctgtac agcaagctga ccgtggacaa gagcagatgg      900

cagcagggca acgtgttcag ctgcagcgtg atgcacgagg ccctgcacaa ccactacacc      960

cagaagtccc tgagcctgag ccccggcaag tgatga                                996


<210>  79
<211>  594
<212>  DNA
<213>  artificial sequence

<220>
<223>  chemically synthesized


<220>
<221>  promoter
<222>  (1)..(594)
<223>  CMV IE promoter

<400>  79
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      360

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      420

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      480

acggtgggag gtctatataa gcagagctcg tttagtgaac cgtcagatcg cctggagacg      540

ccatccacgc tgttttgacc tccatagaag acaccgggac cgatccagcc tccg            594


<210>  80
<211>  58
<212>  DNA
<213>  artificial sequence

<220>
<223>  chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(58)
<223>  Leader sequence from herpes virus TK gene

<400>  80
gatcttggtg gcgtgaaact cccgcacctc ttcggccagc gccttgtaga agcgcgta         58


<210>  81
<211>  60
<212>  DNA
<213>  artificial sequence

<220>
<223>  chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(60)
<223>  mouse immunoglobulin light chain secretion leader peptide cDNA

<400>  81
atgtccgtgc ccacccaggt cctgggcctg ctgctgctgt ggctgacaga cgccaggtgc       60


<210>  82
<211>  327
<212>  DNA
<213>  artificial sequence

<220>
<223>  chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(327)
<223>  human immunoglobulin kappa light chain constant domain cDNA

<400>  82
cgaactgtgg ctgcaccatc tgtcttcatc ttccccccca gcgacgagca gctgaagtcc       60

ggcaccgcca gcgtcgtgtg cctgctgaac aacttctacc cccgggaggc caaggtgcag      120

tggaaggtgg acaacgccct gcagtccggc aacagccagg aaagcgtcac cgagcaggac      180

agcaaggact ccacctacag cctgagcagc accctgaccc tgagcaaggc cgactacgag      240

aagcacaagg tgtacgcctg cgaagtgacc caccagggcc tgtccagccc cgtgaccaag      300

agcttcaacc ggggcgagtg ctgatga                                          327


<210>  83
<211>  321
<212>  DNA
<213>  artificial sequence

<220>
<223>  chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  human immunoglobulin lambda light chain constant domain cDNA

<400>  83
ggtcagccca aggctgcccc ctcggtcact ctgttcccgc cctcctctga ggagcttcaa       60

gccaacaagg ccacactggt ctgcctgatc tccgacttct accctggcgc cgtgaccgtg      120

gcctggaagg ccgattccag ccctgtgaag gccggcgtgg aaaccaccac cccctccaag      180

cagtccaaca acaaatacgc cgcctcctcc tacctgtccc tgacccccga gcagtggaag      240

tcccacagat cctacagctg ccaggtcaca cacgagggct ccaccgtgga aaagaccgtg      300

gcccctaccg agtgctcctg a                                                321


<210>  84
<211>  7093
<212>  DNA
<213>  artificial sequence

<220>
<223>  chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(7093)
<223>  pQMCF IgG shuttle expression vector backbone with human IgG1 
       constant domain and with human immunoglbulin kappa light chain 
       without variable domains

<400>  84
ggtcgccagt cctgttttga caagttgcct ctggaagcct ctacaatgcc tctcttcttt       60

ttctccagag taagcggagg ccaggggccc ccggcctctg cttaatacta aaaaaaacag      120

ctgttgtcat agtaatgatt gggtggaaac attctaggca gatctagtcg ggaggaaaat      180

tactgtgttg gaggccctcc gccatcttct gaagctgatc cccgggggat ccactagtcg      240

ggtatcatat gctgactgta tacgcatgag gatagcatat gctacccgga tacagattag      300

gatagcatat actacccaga tatagattag gatagcatat gctacccaga tatagattag      360

gatagcctat gctacccaga tataaattag gatagcatat actacccaga tatagattag      420

gatagcatat gctacccaga tatagattag gatagcctat gctacccaga tatagattag      480

gatagcatat gctacccaga tatagattag gatagcatat gctatccaga tatttgggta      540

gtatatgcta cccagatata aattaggata gcatatacta ccctaatctc tattaggata      600

gcatatgcta cccggataca gattaggata gcatatacta cccagatata gattaggata      660

gcatatgcta cccagatata gattaggata gcctatgcta cccagatata aattaggata      720

gcatatacta cccagatata gattaggata gcatatgcta cccagatata gattaggata      780

gcctatgcta cccagatata gattaggata gcatatgcta tccagatatt tgggtagtat      840

atgctaccca tggcaacatt agactagttc tagcgaattc tagttctagc tagtctttcc      900

gatcgatgga aggatccgtc ggagctctag aatgagacta ggccgcaagg tagagctccg      960

acggatcctt ccatcgatcg gaaagactag ctagtcctgc aggcctgcta ctgtcttccc     1020

aatcctcccc cttgctgtcc tgccccaccc caccccccag aatagaatga cacctactca     1080

gacaatgcga tgcaatttcc tcattttatt aggaaaggac agtgggagtg gcaccttcca     1140

gggtcaagga aggcacgggg gaggggcaaa caacagatgg ctggcaacta gaaggcacag     1200

tcgaggctaa tcagcgagat ccggccctcg aggaattctt tgccaaaatg atgagacagc     1260

acaacaacca gcacgttgcc caggagctgt aggaaagaga agaaggcatg aacatggtta     1320

gcagaggggc ccggtttgga ctcagagtat tttatcctca tctcaaacag tgtatatcat     1380

tgtaaccata aagagaaagg caggatgatg accagggtgt agttgtttct accaataaga     1440

atatttccac gccagccaga atttatatgc agaaatattc taccttatca tttaattata     1500

acaattgttc tctaaaactg tgctgaagta caatataata taccctgatt gccttgaaaa     1560

aaaagtgatt agagaaagta cttacaatct gacaaataaa caaaagtgaa tttaaaaatt     1620

cgttacaaat gcaagctaaa gtttaacgaa aaagttacag aaaatgaaaa gaaaataaga     1680

ggagacaatg gttgtcaaca gagtagaaag tgaaagaaac aaaattatca tgagggtcca     1740

tggtgataca agggacatct tcccattcta aacaacaccc tgaaaacttt gccccctcca     1800

tataacatga attttacaat agcgaaaaag aaagaacaat caagggtccc caaactcacc     1860

ctgaagttct caggatcggt cgaccatatg ggagagaaac ggcgcttaat taagccggtc     1920

atcagcactc gccccggttg aagctcttgg tcacggggct ggacaggccc tggtgggtca     1980

cttcgcaggc gtacaccttg tgcttctcgt agtcggcctt gctcagggtc agggtgctgc     2040

tcaggctgta ggtggagtcc ttgctgtcct gctcggtgac gctttcctgg ctgttgccgg     2100

actgcagggc gttgtccacc ttccactgca ccttggcctc ccgggggtag aagttgttca     2160

gcaggcacac gacgctggcg gtgccggact tcagctgctc gtcgctgggg gggaagatga     2220

agacagatgg tgcagccaca gttcggcacc tggcgtctgt cagccacagc agcagcaggc     2280

ccaggacctg ggtgggcacg gacatggtgg cttcgaagct tgagctcgag atctgagtcc     2340

ggacttgtac gctagaaggc ctacgcgctt ctacaaggcg ctggccgaag aggtgcggga     2400

gtttcacgcc accaagatcc cccggaggct ggatcggtcc cggtgtcttc tatggaggtc     2460

aaaacagcgt ggatggcgtc tccaggcgat ctgacggttc actaaacgag ctctgcttat     2520

atagacctcc caccgtacac gcctaccgcc catttgcgtc aatggggcgg agttgttacg     2580

acattttgga aagtcccgtt gattttggtg ccaaaacaaa ctcccattga cgtcaatggg     2640

gtggagactt ggaaatcccc gtgagtcaaa ccgctatcca cgcccattga tgtactgcca     2700

aaaccgcatc accatggtaa tagcgatgac taatacgtag atgtactgcc aagtaggaaa     2760

gtcccataag gtcatgtact gggcataatg ccaggcgggc catttaccgt cattgacgtc     2820

aatagggggc gtacttggca tatgatacac ttgatgtact gccaagtggg cagtttaccg     2880

taaatactcc acccattgac gtcaatggaa agtccctatt ggcgttacta tgggaacata     2940

cgtcattatt gacgtcaatg ggcgggggtc gttgggcggt cagccaggcg ggccatttac     3000

cgtaagttat gtaacggggc gagctcgaat tcgctagaac tagcagatct ggtaccctgc     3060

aggtcgaggg tagcgtcgct agttctagcg aattctagta ccctcgacct gcaggtcgat     3120

cgactctagt atggtgcact ctcagtacaa tctgctctga tgccgcatag ttaagccagt     3180

atctgctccc tgcttgtgtg ttggaggtcg ctgagtagtg cgcgagcaaa atttaagcta     3240

caacaaggca aggcttgacc gacaattgca tgaagaatct gcttagggtt aggcgttttg     3300

cgctgcttcg cgatgtacgg gccagatata cgcgtatctg aggggactag ggtgtgttta     3360

ggcgaaaagc ggggcttcgg ttgtacgcgg ttaggagtcc cctcaggata tagtagtttc     3420

gcttttgcat agggaggggg aaatgtagtc ttatgcaata ctcttgtagt cttgcaacat     3480

ggtaacgatg agttagcaac atgccttaca aggagagaaa aagcaccgtg catgccgatt     3540

ggtggaagta aggtggtacg atcgtgcctt attaggaagg caacagacgg gtctgacatg     3600

gattggacga accactgaat tccgcattgc agagatattg tatttaagtg cctagctcga     3660

tacaataaac gccatttgac cattcaccac attggtgtgc acctccaagc tggtagagga     3720

tcggtcgatc gactctagac aggtaagtgg cgtttctcgg ggagccagct gcgtccgctg     3780

tcgtgctgtc ggtgtagtac tagcaagcgt taagtcccca tctggctgcg gcctaccgaa     3840

gagtggtctt cacgtcacac gctgtcccac gcacgtggtt ggtttggtcg cttctggtta     3900

ctgactacta agcagccttt tcttttttcc tttcaggttc tagagcggcc gccaccgaaa     3960

cgccgtaccg ccaccatgga gtggtcttgg gtgttcctgt tctttctgtc cgtgaccaca     4020

ggcgtccaca gcgcctccac caagggccca tcggtcttcc ctctggcccc cagcagcaag     4080

tctaccagcg gcggaacagc cgccctgggc tgcctggtca aggactactt ccccgagccc     4140

gtgaccgtgt cctggaacag cggagccctg acaagcggag tgcacacctt ccctgccgtg     4200

ctgcagtcca gcggcctgta tagcctgagc agcgtcgtga ccgtgcctag cagcagcctg     4260

ggcacccaga cctacatctg caacgtgaac cacaagccca gcaacaccaa ggtggacaag     4320

aaggtggagc ccaagagctg cgacaagacc catacctgcc ccccttgtcc tgcccctgag     4380

ctgctgggcg gacccagcgt gtttctgttc ccccccaagc ccaaggacac cctgatgatc     4440

agccggaccc ccgaagtgac ctgcgtggtg gtggatgtgt cccacgagga ccctgaagtg     4500

aagttcaatt ggtacgtgga cggcgtggag gtgcacaacg ccaagaccaa gccccgggag     4560

gaacagtaca acagcaccta ccgggtggtg tccgtgctga ccgtgctgca ccaggactgg     4620

ctgaacggca aagaatacaa gtgcaaggtg tccaacaagg ccctgcctgc ccccatcgag     4680

aaaaccatca gcaaggccaa gggccagccc agagaacccc aggtgtacac cctgcctccc     4740

agcagagatg agctgaccaa gaaccaggtg tccctgacct gcctcgtgaa gggcttctac     4800

ccctccgata tcgccgtgga gtgggagagc aacggccagc ctgagaacaa ctacaagacc     4860

accccccctg tgctggatag cgacggcagc ttcttcctgt acagcaagct gaccgtggac     4920

aagagcagat ggcagcaggg caacgtgttc agctgcagcg tgatgcacga ggccctgcac     4980

aaccactaca cccagaagtc cctgagcctg agccccggca agtgatgaac cggtggcgcg     5040

cctagccggc cgcgacatga taagatacat tgatgagttt ggacaaacca caactagaat     5100

gcagtgaaaa aaatgcttta tttgtgaaat ttgtgatgct attgctttat ttgtgaaatt     5160

tgtgatgcta ttgctttatt tgtaaccatt ataagctgca ataaacaagt taacaacaac     5220

aattgcattc attttatgtt tcaggttcag ggggaggtgt gggaggtttt ttaaagcaag     5280

taaaacctct acaaatgtgg tagatcattt gacccgcgtt gctggcgttt ttccataggc     5340

tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga     5400

caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc     5460

cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt     5520

ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct     5580

gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg     5640

agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta     5700

gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct     5760

acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa     5820

gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt     5880

gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta     5940

cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat     6000

caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa     6060

gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct     6120

cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta     6180

cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct     6240

caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg     6300

gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa     6360

gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt     6420

cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta     6480

catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca     6540

gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta     6600

ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct     6660

gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg gataataccg     6720

cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac     6780

tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact     6840

gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa     6900

atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt     6960

ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat     7020

gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg     7080

acgtctacct gca                                                        7093


<210>  85
<211>  7091
<212>  DNA
<213>  artificial sequence

<220>
<223>  chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(7091)
<223>  pQMCFgG shuttle expression vector backbone with human IgG1 
       constant domain and with human immunoglobulin lambda light chain 
       without variable domains

<400>  85
ggtcgccagt cctgttttga caagttgcct ctggaagcct ctacaatgcc tctcttcttt       60

ttctccagag taagcggagg ccaggggccc ccggcctctg cttaatacta aaaaaaacag      120

ctgttgtcat agtaatgatt gggtggaaac attctaggca gatctagtcg ggaggaaaat      180

tactgtgttg gaggccctcc gccatcttct gaagctgatc cccgggggat ccactagtcg      240

ggtatcatat gctgactgta tacgcatgag gatagcatat gctacccgga tacagattag      300

gatagcatat actacccaga tatagattag gatagcatat gctacccaga tatagattag      360

gatagcctat gctacccaga tataaattag gatagcatat actacccaga tatagattag      420

gatagcatat gctacccaga tatagattag gatagcctat gctacccaga tatagattag      480

gatagcatat gctacccaga tatagattag gatagcatat gctatccaga tatttgggta      540

gtatatgcta cccagatata aattaggata gcatatacta ccctaatctc tattaggata      600

gcatatgcta cccggataca gattaggata gcatatacta cccagatata gattaggata      660

gcatatgcta cccagatata gattaggata gcctatgcta cccagatata aattaggata      720

gcatatacta cccagatata gattaggata gcatatgcta cccagatata gattaggata      780

gcctatgcta cccagatata gattaggata gcatatgcta tccagatatt tgggtagtat      840

atgctaccca tggcaacatt agactagttc tagcgaattc tagttctagc tagtctttcc      900

gatcgatgga aggatccgtc ggagctctag aatgagacta ggccgcaagg tagagctccg      960

acggatcctt ccatcgatcg gaaagactag ctagtcctgc aggcctgcta ctgtcttccc     1020

aatcctcccc cttgctgtcc tgccccaccc caccccccag aatagaatga cacctactca     1080

gacaatgcga tgcaatttcc tcattttatt aggaaaggac agtgggagtg gcaccttcca     1140

gggtcaagga aggcacgggg gaggggcaaa caacagatgg ctggcaacta gaaggcacag     1200

tcgaggctaa tcagcgagat ccggccctcg aggaattctt tgccaaaatg atgagacagc     1260

acaacaacca gcacgttgcc caggagctgt aggaaagaga agaaggcatg aacatggtta     1320

gcagaggggc ccggtttgga ctcagagtat tttatcctca tctcaaacag tgtatatcat     1380

tgtaaccata aagagaaagg caggatgatg accagggtgt agttgtttct accaataaga     1440

atatttccac gccagccaga atttatatgc agaaatattc taccttatca tttaattata     1500

acaattgttc tctaaaactg tgctgaagta caatataata taccctgatt gccttgaaaa     1560

aaaagtgatt agagaaagta cttacaatct gacaaataaa caaaagtgaa tttaaaaatt     1620

cgttacaaat gcaagctaaa gtttaacgaa aaagttacag aaaatgaaaa gaaaataaga     1680

ggagacaatg gttgtcaaca gagtagaaag tgaaagaaac aaaattatca tgagggtcca     1740

tggtgataca agggacatct tcccattcta aacaacaccc tgaaaacttt gccccctcca     1800

tataacatga attttacaat agcgaaaaag aaagaacaat caagggtccc caaactcacc     1860

ctgaagttct caggatcggt cgaccatatg ggagagaaac ggcgcttaat taaagcgctt     1920

catcaggagc actcggtagg ggccacggtc ttttccacgg tggagccctc gtgtgtgacc     1980

tggcagctgt aggatctgtg ggacttccac tgctcggggg tcagggacag gtaggaggag     2040

gcggcgtatt tgttgttgga ctgcttggag ggggtggtgg tttccacgcc ggccttcaca     2100

gggctggaat cggccttcca ggccacggtc acggcgccag ggtagaagtc ggagatcagg     2160

cagaccagtg tggccttgtt ggcttgaagc tcctcagagg agggcgggaa cagagtgacc     2220

gagggggcag ccttgggctg accgcacctg gcgtctgtca gccacagcag cagcaggccc     2280

aggacctggg tgggcacgga catggtggct tcgaagcttg agctcgagat ctgagtccgg     2340

acttgtacgc tagaaggcct acgcgcttct acaaggcgct ggccgaagag gtgcgggagt     2400

ttcacgccac caagatcccc cggaggctgg atcggtcccg gtgtcttcta tggaggtcaa     2460

aacagcgtgg atggcgtctc caggcgatct gacggttcac taaacgagct ctgcttatat     2520

agacctccca ccgtacacgc ctaccgccca tttgcgtcaa tggggcggag ttgttacgac     2580

attttggaaa gtcccgttga ttttggtgcc aaaacaaact cccattgacg tcaatggggt     2640

ggagacttgg aaatccccgt gagtcaaacc gctatccacg cccattgatg tactgccaaa     2700

accgcatcac catggtaata gcgatgacta atacgtagat gtactgccaa gtaggaaagt     2760

cccataaggt catgtactgg gcataatgcc aggcgggcca tttaccgtca ttgacgtcaa     2820

tagggggcgt acttggcata tgatacactt gatgtactgc caagtgggca gtttaccgta     2880

aatactccac ccattgacgt caatggaaag tccctattgg cgttactatg ggaacatacg     2940

tcattattga cgtcaatggg cgggggtcgt tgggcggtca gccaggcggg ccatttaccg     3000

taagttatgt aacggggcga gctcgaattc gctagaacta gcagatctgg taccctgcag     3060

gtcgagggta gcgtcgctag ttctagcgaa ttctagtacc ctcgacctgc aggtcgatcg     3120

actctagtat ggtgcactct cagtacaatc tgctctgatg ccgcatagtt aagccagtat     3180

ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg cgagcaaaat ttaagctaca     3240

acaaggcaag gcttgaccga caattgcatg aagaatctgc ttagggttag gcgttttgcg     3300

ctgcttcgcg atgtacgggc cagatatacg cgtatctgag gggactaggg tgtgtttagg     3360

cgaaaagcgg ggcttcggtt gtacgcggtt aggagtcccc tcaggatata gtagtttcgc     3420

ttttgcatag ggagggggaa atgtagtctt atgcaatact cttgtagtct tgcaacatgg     3480

taacgatgag ttagcaacat gccttacaag gagagaaaaa gcaccgtgca tgccgattgg     3540

tggaagtaag gtggtacgat cgtgccttat taggaaggca acagacgggt ctgacatgga     3600

ttggacgaac cactgaattc cgcattgcag agatattgta tttaagtgcc tagctcgata     3660

caataaacgc catttgacca ttcaccacat tggtgtgcac ctccaagctg gtagaggatc     3720

ggtcgatcga ctctagacag gtaagtggcg tttctcgggg agccagctgc gtccgctgtc     3780

gtgctgtcgg tgtagtacta gcaagcgtta agtccccatc tggctgcggc ctaccgaaga     3840

gtggtcttca cgtcacacgc tgtcccacgc acgtggttgg tttggtcgct tctggttact     3900

gactactaag cagccttttc ttttttcctt tcaggttcta gagcggccgc caccgaaacg     3960

ccgtaccgcc accatggagt ggtcttgggt gttcctgttc tttctgtccg tgaccacagg     4020

cgtccacagc gcctccacca agggcccatc ggtcttccct ctggccccca gcagcaagtc     4080

taccagcggc ggaacagccg ccctgggctg cctggtcaag gactacttcc ccgagcccgt     4140

gaccgtgtcc tggaacagcg gagccctgac aagcggagtg cacaccttcc ctgccgtgct     4200

gcagtccagc ggcctgtata gcctgagcag cgtcgtgacc gtgcctagca gcagcctggg     4260

cacccagacc tacatctgca acgtgaacca caagcccagc aacaccaagg tggacaagaa     4320

ggtggagccc aagagctgcg acaagaccca tacctgcccc ccttgtcctg cccctgagct     4380

gctgggcgga cccagcgtgt ttctgttccc ccccaagccc aaggacaccc tgatgatcag     4440

ccggaccccc gaagtgacct gcgtggtggt ggatgtgtcc cacgaggacc ctgaagtgaa     4500

gttcaattgg tacgtggacg gcgtggaggt gcacaacgcc aagaccaagc cccgggagga     4560

acagtacaac agcacctacc gggtggtgtc cgtgctgacc gtgctgcacc aggactggct     4620

gaacggcaaa gaatacaagt gcaaggtgtc caacaaggcc ctgcctgccc ccatcgagaa     4680

aaccatcagc aaggccaagg gccagcccag agaaccccag gtgtacaccc tgcctcccag     4740

cagagatgag ctgaccaaga accaggtgtc cctgacctgc ctcgtgaagg gcttctaccc     4800

ctccgatatc gccgtggagt gggagagcaa cggccagcct gagaacaact acaagaccac     4860

cccccctgtg ctggatagcg acggcagctt cttcctgtac agcaagctga ccgtggacaa     4920

gagcagatgg cagcagggca acgtgttcag ctgcagcgtg atgcacgagg ccctgcacaa     4980

ccactacacc cagaagtccc tgagcctgag ccccggcaag tgatgaaccg gtggcgcgcc     5040

tagccggccg cgacatgata agatacattg atgagtttgg acaaaccaca actagaatgc     5100

agtgaaaaaa atgctttatt tgtgaaattt gtgatgctat tgctttattt gtgaaatttg     5160

tgatgctatt gctttatttg taaccattat aagctgcaat aaacaagtta acaacaacaa     5220

ttgcattcat tttatgtttc aggttcaggg ggaggtgtgg gaggtttttt aaagcaagta     5280

aaacctctac aaatgtggta gatcatttga cccgcgttgc tggcgttttt ccataggctc     5340

cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg aaacccgaca     5400

ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc tcctgttccg     5460

accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt ggcgctttct     5520

catagctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa gctgggctgt     5580

gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta tcgtcttgag     5640

tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa caggattagc     5700

agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa ctacggctac     5760

actagaagaa cagtatttgg tatctgcgct ctgctgaagc cagttacctt cggaaaaaga     5820

gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt ttttgtttgc     5880

aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat cttttctacg     5940

gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat gagattatca     6000

aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc aatctaaagt     6060

atatatgagt aaacttggtc tgacagttac caatgcttaa tcagtgaggc acctatctca     6120

gcgatctgtc tatttcgttc atccatagtt gcctgactcc ccgtcgtgta gataactacg     6180

atacgggagg gcttaccatc tggccccagt gctgcaatga taccgcgaga cccacgctca     6240

ccggctccag atttatcagc aataaaccag ccagccggaa gggccgagcg cagaagtggt     6300

cctgcaactt tatccgcctc catccagtct attaattgtt gccgggaagc tagagtaagt     6360

agttcgccag ttaatagttt gcgcaacgtt gttgccattg ctacaggcat cgtggtgtca     6420

cgctcgtcgt ttggtatggc ttcattcagc tccggttccc aacgatcaag gcgagttaca     6480

tgatccccca tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat cgttgtcaga     6540

agtaagttgg ccgcagtgtt atcactcatg gttatggcag cactgcataa ttctcttact     6600

gtcatgccat ccgtaagatg cttttctgtg actggtgagt actcaaccaa gtcattctga     6660

gaatagtgta tgcggcgacc gagttgctct tgcccggcgt caatacggga taataccgcg     6720

ccacatagca gaactttaaa agtgctcatc attggaaaac gttcttcggg gcgaaaactc     6780

tcaaggatct taccgctgtt gagatccagt tcgatgtaac ccactcgtgc acccaactga     6840

tcttcagcat cttttacttt caccagcgtt tctgggtgag caaaaacagg aaggcaaaat     6900

gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa tactcatact cttccttttt     6960

caatattatt gaagcattta tcagggttat tgtctcatga gcggatacat atttgaatgt     7020

atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt gccacctgac     7080

gtctacctgc a                                                          7091


<210>  86
<211>  27
<212>  DNA
<213>  artificial sequence

<220>
<223>  chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(27)
<223>  23G7 CDR L1 DNA

<400>  86
agcagtgacg ttggtgttta taactat                                           27


<210>  87
<211>  9
<212>  DNA
<213>  artificial sequence

<220>
<223>  chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  23G7 CDR L2 DNA

<400>  87
gatgtcagt                                                                9


<210>  88
<211>  30
<212>  DNA
<213>  artificial sequence

<220>
<223>  chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(30)
<223>  23G7 CDR L3 DNA

<400>  88
agctcatata caagcagcag cactctggta                                        30


<210>  89
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  chemically synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  23G7 CDR L1 protein

<400>  89

Ser Ser Asp Val Gly Val Tyr Asn Tyr 
1               5                   


<210>  90
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  Chemically synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  23G7 CDR L2 protein

<400>  90

Asp Val Ser 
1           


<210>  91
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  chemically synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  23G7 CDR L3 protein

<400>  91

Ser Ser Tyr Thr Ser Ser Ser Thr Leu Val 
1               5                   10  


<210>  92
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(24)
<223>  23G7 CDR H1 DNA

<400>  92
ggatacacct tcaccggcta ctat                                              24


<210>  93
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(24)
<223>  23G7 CDR H2 DNA

<400>  93
atcaacccta tcagtggtgg caca                                              24


<210>  94
<211>  45
<212>  DNA
<213>  artificial sequence

<220>
<223>  chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(45)
<223>  23G7 CDR H3 DNA

<400>  94
gcgagaggac acacgtataa ctggaactac gcctactgtg actac                       45


<210>  95
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  chemically synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  23G7 CDR H1 protein

<400>  95

Gly Tyr Thr Phe Thr Gly Tyr Tyr 
1               5               


<210>  96
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  chemcially synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  23G7 CDR H2 protein

<400>  96

Ile Asn Pro Ile Ser Gly Gly Thr 
1               5               


<210>  97
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  chemically synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  23G7 CDR H3 protein

<400>  97

Ala Arg Gly His Thr Tyr Asn Trp Asn Tyr Ala Tyr Cys Asp Tyr 
1               5                   10                  15  


<210>  98
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  chemically synthesized


<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  VL lambda forward primer HiLIC_13

<400>  98
ggctgacaga cgccaggtgc aattttatgc tgactcagcc cca                         43


