                         SEQUENCE LISTING

<110>  Gyroscope Therapeutics Limited
 
<120>  Product

<130>  P121218PCT

<150>  GB 2016463.8
<151>  2020-10-16

<160>  68    

<170>  PatentIn version 3.5

<210>  1
<211>  431
<212>  PRT
<213>  Unknown

<220>
<223>  illustrative aflibercept amino acid sequence

<400>  1

Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
1               5                   10                  15      


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
            20                  25                  30          


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
        35                  40                  45              


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
    50                  55                  60                  


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
65                  70                  75                  80  


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
                85                  90                  95      


Gln Thr Asn Thr Ile Ile Asp Val Val Leu Ser Pro Ser His Gly Ile 
            100                 105                 110         


Glu Leu Ser Val Gly Glu Lys Leu Val Leu Asn Cys Thr Ala Arg Thr 
        115                 120                 125             


Glu Leu Asn Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys 
    130                 135                 140                 


His Gln His Lys Lys Leu Val Asn Arg Asp Leu Lys Thr Gln Ser Gly 
145                 150                 155                 160 


Ser Glu Met Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp Gly Val Thr 
                165                 170                 175     


Arg Ser Asp Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met 
            180                 185                 190         


Thr Lys Lys Asn Ser Thr Phe Val Arg Val His Glu Lys Asp Lys Thr 
        195                 200                 205             


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
    210                 215                 220                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
225                 230                 235                 240 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                245                 250                 255     


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            260                 265                 270         


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
        275                 280                 285             


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    290                 295                 300                 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
305                 310                 315                 320 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                325                 330                 335     


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
            340                 345                 350         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        355                 360                 365             


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    370                 375                 380                 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
385                 390                 395                 400 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                405                 410                 415     


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            420                 425                 430     


<210>  2
<211>  1296
<212>  DNA
<213>  Unknown

<220>
<223>  polynucleotide sequence encoding aflibercept amino acid sequence

<400>  2
agtgatacag gtagaccttt cgtagagatg tacagtgaaa tccccgaaat tatacacatg       60

actgaaggaa gggagctcgt cattccctgc cgggttacgt cacctaacat cactgttact      120

ttaaaaaagt ttccacttga cactttgatc cctgatggaa aacgcataat ctgggacagt      180

agaaagggct tcatcatatc aaatgcaacg tacaaagaaa tagggcttct gacctgtgaa      240

gcaacagtca atgggcattt gtataagaca aactatctca cacatcgaca aaccaataca      300

atcatagatg tcgttctgag tccgtctcat ggaattgaac tatctgttgg agaaaagctt      360

gtcttaaatt gtacagcaag aactgaacta aatgtgggga ttgacttcaa ctgggaatac      420

ccttcttcga agcatcagca taagaaactt gtaaaccgag acctaaaaac ccagtctggg      480

agtgagatga agaaattttt gagcacctta actatagatg gtgtaacccg gagtgaccaa      540

ggattgtaca cctgtgcagc atccagtggg ctgatgacca agaagaacag cacatttgtc      600

agggtccatg aaaaagacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      660

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      720

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      780

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      840

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      900

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      960

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1020

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1080

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1140

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1200

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1260

tacacgcaga agagcctctc cctgtctccg ggttga                               1296


<210>  3
<211>  1296
<212>  DNA
<213>  Unknown

<220>
<223>  Illustrative codon optimized nucleotide sequences encoding 
       aflibercept

<400>  3
tctgataccg gcagaccctt cgtggaaatg tacagcgaga tccccgagat catccacatg       60

accgagggca gagagctggt catcccctgc agagtgacaa gccccaacat caccgtgact      120

ctgaagaagt tccctctgga cacactgatc cccgacggca agagaatcat ctgggacagc      180

cggaagggct tcatcatcag caacgccacc tacaaagaga tcggcctgct gacctgtgaa      240

gccaccgtga atggccacct gtacaagacc aactacctga cacacagaca gaccaacacc      300

atcatcgacg tggtgctgag ccctagccac ggcattgaac tgtctgtggg cgagaagctg      360

gtgctgaact gtaccgccag aaccgagctg aacgtgggca tcgacttcaa ctgggagtac      420

cccagcagca agcaccagca caagaaactg gtcaaccggg acctgaaaac ccagagcggc      480

agcgagatga agaaattcct gagcaccctg accatcgacg gcgtgaccag atctgaccag      540

ggcctgtaca catgtgccgc cagctctggc ctgatgacca agaaaaacag caccttcgtg      600

cgggtgcacg agaaggacaa gacccacacc tgtcctccat gtcctgctcc agaactgctc      660

ggcggacctt ccgtgttcct gtttcctcca aagcctaagg acaccctgat gatcagcaga      720

acccctgaag tgacctgcgt ggtggtggat gtgtcccacg aggatcccga agtgaagttc      780

aattggtacg tggacggcgt ggaagtgcac aacgccaaga ccaagcctag agaggaacag      840

tacaatagca cctacagagt ggtgtccgtg ctgaccgtgc tgcaccagga ttggctgaac      900

ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgctcctat cgagaaaacc      960

atctccaagg ccaagggcca gcctagggaa ccccaggttt acacactgcc tccaagcagg     1020

gacgagctga caaagaacca ggtgtccctg acctgcctgg tcaagggctt ctacccttcc     1080

gatatcgccg tggaatggga gagcaatggc cagcctgaga acaactacaa gacaacccct     1140

cctgtgctgg acagcgacgg ctcattcttc ctgtacagca agctgacagt ggacaagagc     1200

agatggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1260

tacacccaga agtccctgag cctgtctcct ggctaa                               1296


<210>  4
<211>  1296
<212>  DNA
<213>  Unknown

<220>
<223>  Illustrative codon optimized nucleotide sequences encoding 
       aflibercept

<400>  4
tctgataccg gcagaccctt cgtggaaatg tacagcgaga tccccgagat cattcacatg       60

accgagggca gagagctggt catcccctgc cgagtgacaa gccccaacat caccgtgact      120

ctgaagaaat tccctctgga cacactgatc cccgacggca agagaatcat ttgggacagc      180

cggaagggct tcatcattag caacgccacc tacaaagaga tcggcctgct cacctgtgaa      240

gccaccgtga atggccacct gtacaagacc aactacctga cacacagaca gaccaacacc      300

atcattgacg tggtcctgag ccctagccac ggcattgaac tgtctgtggg cgagaagctg      360

gtgctgaact gtaccgccag aaccgagctg aacgtgggca tcgacttcaa ctgggagtac      420

cccagctcca agcaccagca caagaaactg gtcaaccggg acctgaaaac ccagagcggc      480

agcgagatga agaaattcct gagcaccctg accatcgacg gcgtgaccag atctgaccag      540

ggcctgtaca catgtgccgc tagctctggc ctgatgacca agaaaaacag caccttcgtg      600

cgggtgcacg agaaggacaa gacccacacc tgtcctccat gtcctgctcc cgaactgctc      660

ggcggacctt ccgtgttcct gtttcctcca aagcctaagg acaccctgat gatcagcaga      720

acccctgaag tgacctgcgt ggtcgtggat gtgtcccacg aggatcccga agtgaagttc      780

aattggtacg tggacggcgt ggaagtgcac aacgccaaga ccaagcctag agaggaacag      840

tacaatagca cctacagagt ggtctccgtg ctgaccgtgc tgcaccagga ttggctgaac      900

ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgctcctat cgagaaaacc      960

atctccaagg ccaagggcca gcctagggaa ccccaggttt acacactgcc tccaagcagg     1020

gacgagctga caaagaacca ggtgtccctg acctgcctgg tcaagggctt ctacccttcc     1080

gatatcgccg tggaatggga gagcaatggc cagcctgaga acaattacaa gacaacccct     1140

cccgtgctgg acagcgacgg ctcattcttt ctgtactcca agctgacagt ggacaagagc     1200

agatggcagc aaggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1260

tacacccaga agtccctgag cctgtctcct ggctaa                               1296


<210>  5
<211>  1296
<212>  DNA
<213>  Unknown

<220>
<223>  Illustrative codon optimized nucleotide sequences encoding 
       aflibercept

<400>  5
agcgacaccg gcagaccctt cgtggagatg tactccgaga tccctgagat catccacatg       60

accgagggca gggagctggt catcccatgc cgcgtgacat cccccaacat caccgtgaca      120

ctgaagaagt tccctctgga caccctgatc ccagatggca agcggatcat ctgggactct      180

agaaagggct ttatcatcag caatgccaca tataaggaga tcggcctgct gacctgcgag      240

gccacagtga acggccacct gtacaagacc aattatctga cacacagaca gaccaacaca      300

atcatcgatg tggtgctgtc cccatctcac ggcatcgagc tgagcgtggg cgagaagctg      360

gtgctgaatt gtaccgccag gacagagctg aacgtgggca tcgacttcaa ttgggagtac      420

cccagctcca agcaccagca caagaagctg gtgaacaggg atctgaagac ccagagcggc      480

tccgagatga agaagtttct gtctaccctg acaatcgacg gagtgacccg cagcgatcag      540

ggactgtata catgcgccgc ctctagcggc ctgatgacca agaagaacag caccttcgtg      600

cgggtgcacg agaaggacaa gacccacaca tgcccacctt gtccagcacc agagctgctg      660

ggaggaccaa gcgtgttcct gtttccaccc aagcccaagg ataccctgat gatctctcgc      720

acccccgagg tgacatgcgt ggtggtggac gtgagccacg aggaccccga ggtgaagttt      780

aactggtacg tggacggcgt ggaggtgcac aatgccaaga ccaagcctcg ggaggagcag      840

tacaacagca cctatagagt ggtgtccgtg ctgacagtgc tgcaccagga ttggctgaac      900

ggcaaggagt ataagtgcaa ggtgtccaat aaggccctgc ctgccccaat cgagaagacc      960

atctctaagg caaagggaca gcccagggag cctcaggtgt acacactgcc tccatcccgc     1020

gacgagctga ccaagaacca ggtgtctctg acatgtctgg tgaagggctt ctatcctagc     1080

gacatcgccg tggagtggga gtccaatggc cagccagaga acaattacaa gaccacaccc     1140

cctgtgctgg actccgatgg ctctttcttt ctgtattcca agctgaccgt ggataagtct     1200

cggtggcagc agggcaacgt gttttcttgt agcgtgatgc acgaggccct gcacaatcac     1260

tacacacaga agtccctgtc tctgagcccc ggctga                               1296


<210>  6
<211>  1296
<212>  DNA
<213>  Unknown

<220>
<223>  Illustrative codon optimized nucleotide sequences encoding 
       aflibercept

<400>  6
agcgacaccg gcagaccctt cgtggagatg tactccgaga tccctgagat cattcacatg       60

accgagggca gggagctggt catcccatgc cgcgtgacat cccccaacat caccgtgaca      120

ctgaagaaat tccctctgga caccctgatc ccagatggca agcggatcat ttgggactct      180

agaaagggct ttatcattag caatgccaca tataaggaga tcggcctgct cacctgcgag      240

gccacagtga acggccacct gtacaagacc aattatctga cacacagaca gaccaacaca      300

atcattgatg tggtcctgtc cccatctcac ggcatcgagc tgagcgtggg cgagaagctg      360

gtgctgaatt gtaccgccag gacagagctg aacgtgggca tcgacttcaa ttgggagtac      420

cccagctcca agcaccagca caagaaactg gtgaacaggg atctgaagac ccagagcggc      480

tccgagatga agaaatttct gtctaccctg acaatcgacg gagtgacccg cagcgatcag      540

ggactgtata catgcgccgc ttctagcggc ctgatgacca agaaaaacag caccttcgtg      600

cgggtgcacg agaaggacaa gacccacaca tgcccacctt gtccagcacc agagctgctc      660

ggaggcccaa gcgtgttcct gtttccaccc aagcccaagg ataccctgat gatctctcgc      720

acccccgagg tgacatgcgt ggtcgtggac gtgagccacg aggaccccga ggtgaagttt      780

aactggtatg tggacggcgt ggaggtgcac aatgccaaga ccaagcctcg ggaggaacag      840

tacaacagca cctatagagt ggtctccgtg ctgacagtgc tgcaccagga ttggctgaac      900

ggcaaggagt ataagtgcaa ggtgtccaat aaggccctgc ctgccccaat cgagaagacc      960

atctctaagg caaagggaca gcccagggag cctcaggtgt acacactgcc tccatcccgc     1020

gacgagctga ccaagaacca ggtgtctctg acatgtctgg tgaagggctt ctatcctagc     1080

gacatcgccg tggagtggga gtccaatggc cagccagaga acaattacaa gaccacaccc     1140

cctgtgctgg actccgatgg ctctttcttt ctgtattcca agctgaccgt ggataagtct     1200

cggtggcagc aaggcaacgt gttttcttgt tccgtgatgc acgaggccct gcacaatcac     1260

tacacacaga agtccctgtc tctgagcccc ggctga                               1296


<210>  7
<211>  1296
<212>  DNA
<213>  Unknown

<220>
<223>  Illustrative codon optimized nucleotide sequences encoding 
       aflibercept

<400>  7
tccgacaccg gcagaccctt cgtggagatg tacagcgaga tccccgagat cattcacatg       60

accgagggca gagagctcgt gatcccttgt agagtgacct cccccaacat caccgtgaca      120

ctgaagaagt ttcctctgga taccctcatc cccgacggca agaggattat ttgggactct      180

agaaagggct tcatcattag caacgccacc tacaaggaga tcggactgct gacatgcgag      240

gccaccgtga acggccacct ctacaagacc aactatctga cccatagaca gaccaatacc      300

atcatcgacg tggtgctctc ccctagccac ggaatcgagc tgagcgtggg cgagaaactg      360

gtgctcaatt gcaccgctag aacagagctc aacgtgggca tcgacttcaa ctgggaatac      420

ccctcctcca agcaccaaca caagaagctc gtgaatagag atctgaagac ccaaagcggc      480

agcgagatga agaagtttct gagcacactg acaattgacg gcgtcacaag aagcgaccaa      540

ggcctctata catgcgccgc cagcagcgga ctgatgacca agaagaacag caccttcgtg      600

agagtgcacg agaaagataa gacccacaca tgtccccctt gccccgcccc cgagctgctg      660

ggaggaccta gcgtctttct gttccctcct aagcccaagg acacactgat gatctccaga      720

acccccgagg tgacatgcgt ggtcgtggac gtgtcccacg aggaccccga ggtgaagttc      780

aattggtacg tcgacggcgt ggaggtgcac aatgctaaga ccaagcccag agaggagcag      840

tacaactcca cctacagagt ggtgtccgtg ctgaccgtgc tccatcaaga ctggctcaac      900

ggcaaggagt acaagtgcaa ggtgagcaac aaggccctcc ccgcccctat cgagaagacc      960

atttccaagg ccaagggcca gcctagagag ccccaagtgt atacactgcc tcccagcaga     1020

gacgagctca ccaaaaacca agtgtccctc acatgtctgg tcaaaggctt ctaccccagc     1080

gatatcgccg tggagtggga aagcaacggc cagcccgaga acaactacaa gacaacccct     1140

cccgtgctcg acagcgacgg aagcttcttt ctgtacagca agctgaccgt ggacaagtct     1200

agatggcagc aaggcaatgt ctttagctgc agcgtgatgc acgaggctct gcacaatcac     1260

tacacccaga agagcctctc tctgagcccc ggctga                               1296


<210>  8
<211>  1296
<212>  DNA
<213>  Unknown

<220>
<223>  Illustrative codon optimized nucleotide sequences encoding 
       aflibercept

<400>  8
tccgacaccg gcagaccctt cgtggagatg tacagcgaga tccccgagat cattcacatg       60

accgagggca gagagctcgt gatcccttgt cgagtgacct cccccaacat caccgtgaca      120

ctgaagaaat ttcctctgga taccctcatc cccgacggca agaggattat ctgggactct      180

agaaagggct tcatcattag caacgccacc tacaaggaga tcggactgct tacatgcgag      240

gccaccgtga acggccacct ctacaagacc aactatctga cccatagaca gaccaatacc      300

atcattgacg tggttctctc cccttctcac ggaatcgagc tgagcgtggg cgagaaactg      360

gtgctcaatt gcaccgctag aacagagctc aacgtgggca tcgacttcaa ctgggaatac      420

ccctcctcta agcaccaaca caagaaactc gtgaatagag atctgaagac ccaaagcggc      480

agcgagatga agaaatttct gagcacactg acaattgacg gcgtcacaag aagcgaccaa      540

ggcctctata catgcgccgc tagcagtgga ctgatgacca agaaaaacag caccttcgtg      600

agagtgcacg agaaagataa gacccacaca tgtccccctt gccccgcccc cgagctgctt      660

ggaggtccta gcgtctttct gttccctcca aagcccaagg acacactgat gatctccaga      720

acccccgagg tgacatgcgt ggtcgtggac gtgtcccacg aggaccccga ggtgaagttc      780

aattggtatg ttgacggcgt ggaggtgcac aatgctaaga ccaagcccag agaggaacag      840

tacaactcca cctacagagt ggtttccgtg ctgaccgtgc tccatcaaga ctggctcaac      900

ggcaaggagt acaagtgcaa agtgagcaac aaggccctcc ccgcccctat cgagaagacc      960

atttccaagg ccaagggcca gcctagagag ccccaagtgt atacactgcc tcccagcaga     1020

gacgagctca ccaaaaacca agtgtccctc acatgtctgg tcaaaggctt ctaccccagc     1080

gatatcgccg tggagtggga aagcaacggc cagcccgaga acaattacaa gacaacccct     1140

cccgtgctcg acagcgacgg aagcttcttt ctgtactcca agctgaccgt ggacaagtct     1200

agatggcagc aaggcaatgt ctttagctgc agcgtgatgc acgaggctct gcacaatcac     1260

tacacccaga agagcctctc tctgagcccc ggctga                               1296


<210>  9
<211>  1296
<212>  DNA
<213>  Unknown

<220>
<223>  Illustrative codon optimized nucleotide sequences encoding 
       aflibercept

<400>  9
tccgacaccg ggagaccgtt tgtagaaatg tactctgaaa ttccagaaat tattcacatg       60

actgaaggac gagaactcgt aatcccgtgc cgggtaacat caccgaacat taccgttact      120

ctcaagaagt tcccgttgga cactctgatt ccagacggca agcggattat atgggattca      180

cgaaaaggct ttatcatcag caacgctaca tataaggaga taggcctcct cacctgcgag      240

gccacagtga acggacacct ttacaagaca aactacctca cgcatcgcca gactaacact      300

attatagacg ttgtactcag cccttcccac ggaatagagc tctctgttgg ggaaaagctt      360

gttctgaact gcacggcacg aaccgaactc aacgttggta ttgatttcaa ctgggaatac      420

ccctcttcaa agcaccaaca taagaagctc gtgaacaggg acctgaagac gcagagtgga      480

tccgaaatga agaaatttct ttcaactctc acaatcgacg gcgttaccag gagcgatcag      540

gggctttata cttgcgcggc ttcttctgga ctcatgacaa agaaaaacag tactttcgtt      600

cgcgtccatg agaaagataa gacccatacg tgcccacctt gtccagctcc ggaacttttg      660

ggcggaccca gcgtatttct ttttcctccc aagccgaaag acacactgat gatatcaaga      720

actcctgaag ttacatgtgt tgttgttgac gttagtcatg aagaccctga ggtcaagttc      780

aactggtatg ttgatggagt agaggttcat aacgcgaaga cgaagccacg agaagaacag      840

tacaacagca cgtatagggt ggtcagtgta cttacggtac tccaccaaga ttggcttaac      900

ggtaaggaat acaagtgtaa agtatctaat aaggcattgc cggctccgat tgaaaagaca      960

atctctaagg caaaaggcca gccgcgcgag ccgcaagtat atacattgcc tccctcaaga     1020

gatgagctta ccaagaacca ggtgagcctg acatgccttg tcaaaggatt ctaccctagc     1080

gacatagccg tcgaatggga atcaaacggt caaccagaga acaattataa aaccaccccc     1140

ccggtgcttg atagtgatgg ctcctttttt ctgtattcta agttgacggt ggataagagt     1200

cggtggcaac aggggaatgt atttagttgc agtgtgatgc acgaggctct tcataaccac     1260

tacacacaaa aatctttgag cttgtctcca ggttga                               1296


<210>  10
<211>  1296
<212>  DNA
<213>  Unknown

<220>
<223>  Illustrative codon optimized nucleotide sequences encoding 
       aflibercept

<400>  10
tccgacaccg ggagaccgtt tgtagaaatg tactctgaaa ttccagaaat tatccacatg       60

actgaaggac gagaactcgt aatcccgtgc cgggtaacat caccgaacat taccgttact      120

ctcaagaaat tcccgttgga cactctgatt ccagacggca agcggattat atgggattca      180

cgaaaaggct ttatcattag caacgctaca tataaggaga taggcctcct gacctgcgag      240

gccacagtga acggacacct ttacaagaca aactacctca cgcatcgcca gactaacact      300

attatagacg ttgtactcag cccttcccac ggaatagagc tctctgttgg ggaaaagctt      360

gttctgaact gcacggcacg aaccgaactc aacgttggta ttgatttcaa ctgggaatac      420

ccctcttcaa agcaccaaca taagaaactc gtgaacaggg acctgaagac gcagagtgga      480

tccgaaatga agaaatttct ttcaactctc acaatcgacg gcgttaccag gagcgatcag      540

gggctttata cttgcgcggc ttcttccgga ctcatgacaa agaaaaacag tactttcgtt      600

cgcgtccatg agaaagataa gacccatacg tgcccacctt gtccagctcc ggaacttttg      660

ggcggaccca gcgtatttct ttttcctccc aagccgaaag acacactgat gatatcaaga      720

actcctgaag ttacatgtgt tgtggttgac gtcagtcatg aagaccctga ggtcaagttc      780

aactggtatg ttgatggagt agaggttcat aacgcgaaga cgaagccacg agaagagcag      840

tacaacagca cgtatagggt ggtcagtgta cttacggtac tccaccaaga ttggcttaac      900

ggaaaggaat acaagtgtaa agtatctaat aaggcattgc cggctccgat tgaaaagaca      960

atctctaagg caaaaggcca gccgcgcgag ccgcaagtat atacattgcc tccctcaaga     1020

gatgagctta ccaagaacca ggtttctctg acatgccttg tcaaaggatt ctaccctagc     1080

gacatagccg tcgaatggga atcaaacggt caaccagaga acaattataa aaccacaccc     1140

ccggtgcttg atagtgatgg ctcctttttc ctgtattcta agttgacggt ggataagagt     1200

cggtggcaac aggggaatgt atttagttgc agtgtgatgc acgaggctct tcataaccac     1260

tacacacaaa aatctttgag cttgtctcca ggttga                               1296


<210>  11
<211>  1296
<212>  DNA
<213>  Unknown

<220>
<223>  Illustrative codon optimized nucleotide sequences encoding 
       aflibercept

<400>  11
agcgacaccg gccgcccctt cgtggagatg tacagcgaga tccccgagat catccacatg       60

accgagggcc gcgagctggt gatcccctgc cgcgtgacca gccccaacat caccgtgacc      120

ctgaagaagt tccccctgga caccctgatc cccgacggca agcgcatcat ctgggacagc      180

cgcaagggct tcatcatcag caacgccacc tacaaggaga tcggcctgct gacctgcgag      240

gccaccgtga acggccacct gtacaagacc aactacctga cccaccgcca gaccaacacc      300

atcatcgacg tggtgctgag ccccagccac ggcatcgagc tgagcgtggg cgagaagctg      360

gtgctgaact gcaccgcccg caccgagctg aacgtgggca tcgacttcaa ctgggagtac      420

cccagcagca agcaccagca caagaagctg gtgaaccgcg acctgaagac ccagagcggc      480

agcgagatga agaagttcct gagcaccctg accatcgacg gcgtgacccg cagcgaccag      540

ggcctgtaca cctgcgccgc cagcagcggc ctgatgacca agaagaacag caccttcgtg      600

cgcgtgcacg agaaggacaa gacccacacc tgccccccct gccccgcccc cgagctgctg      660

ggcggcccca gcgtgttcct gttccccccc aagcccaagg acaccctgat gatcagccgc      720

acccccgagg tgacctgcgt ggtggtggac gtgagccacg aggaccccga ggtgaagttc      780

aactggtacg tggacggcgt ggaggtgcac aacgccaaga ccaagccccg cgaggagcag      840

tacaacagca cctaccgcgt ggtgagcgtg ctgaccgtgc tgcaccagga ctggctgaac      900

ggcaaggagt acaagtgcaa ggtgagcaac aaggccctgc ccgcccccat cgagaagacc      960

atcagcaagg ccaagggcca gccccgcgag ccccaggtgt acaccctgcc ccccagccgc     1020

gacgagctga ccaagaacca ggtgagcctg acctgcctgg tgaagggctt ctaccccagc     1080

gacatcgccg tggagtggga gagcaacggc cagcccgaga acaactacaa gaccaccccc     1140

cccgtgctgg acagcgacgg cagcttcttc ctgtacagca agctgaccgt ggacaagagc     1200

cgctggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1260

tacacccaga agagcctgag cctgagcccc ggctaa                               1296


<210>  12
<211>  231
<212>  PRT
<213>  Unknown

<220>
<223>  Ranibizumab heavy chain variable sequence

<400>  12

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Asp Phe Thr His Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  


Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Pro Tyr Tyr Tyr Gly Thr Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Leu 
225                 230     


<210>  13
<211>  214
<212>  PRT
<213>  Unknown

<220>
<223>  Ranibizumab light chain variable sequence

<400>  13

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  14
<211>  693
<212>  DNA
<213>  Unknown

<220>
<223>  Examples polynucleotide sequence encoding Ranibizumab heavy chain
       variable polypeptide

<400>  14
gaggtgcagc tggtggagag cggcggcggc ctggtgcagc ccggcggcag cctgcgcctg       60

agctgcgccg ccagcggcta cgacttcacc cactacggca tgaactgggt gcgccaggcc      120

cccggcaagg gcctggagtg ggtgggctgg atcaacacct acaccggcga gcccacctac      180

gccgccgact tcaagcgccg cttcaccttc agcctggaca ccagcaagag caccgcctac      240

ctgcagatga acagcctgcg cgccgaggac accgccgtgt actactgcgc caagtacccc      300

tactactacg gcaccagcca ctggtacttc gacgtgtggg gccagggcac cctggtgacc      360

gtgagcagcg ccagcaccaa gggccccagc gtgttccccc tggcccccag cagcaagagc      420

accagcggcg gcaccgccgc cctgggctgc ctggtgaagg actacttccc cgagcccgtg      480

accgtgagct ggaacagcgg cgccctgacc agcggcgtgc acaccttccc cgccgtgctg      540

cagagcagcg gcctgtacag cctgagcagc gtggtgaccg tgcccagcag cagcctgggc      600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag      660

gtggagccca agagctgcga caagacccac ctg                                   693


<210>  15
<211>  642
<212>  DNA
<213>  Unknown

<220>
<223>  Examples polynucleotide sequence encoding Ranibizumab light chain
       variable polypeptide

<400>  15
gacatccagc tgacccagag ccccagcagc ctgagcgcca gcgtgggcga ccgcgtgacc       60

atcacctgca gcgccagcca ggacatcagc aactacctga actggtacca gcagaagccc      120

ggcaaggccc ccaaggtgct gatctacttc accagcagcc tgcacagcgg cgtgcccagc      180

cgcttcagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag tacagcaccg tgccctggac cttcggccag      300

ggcaccaagg tggagatcaa gcgcaccgtg gccgccccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc      600

ctgagcagcc ccgtgaccaa gagcttcaac cgcggcgagt gc                         642


<210>  16
<211>  453
<212>  PRT
<213>  Unknown

<220>
<223>  Bevacizumab heavy chain

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  


Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Pro His Tyr Tyr Gly Ser Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  17
<211>  214
<212>  PRT
<213>  Unknown

<220>
<223>  Bevacizumab light chain

<400>  17

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  18
<211>  1359
<212>  DNA
<213>  Unknown

<220>
<223>  Example polynucleotide sequence encoding Bevacizumab heavy chain 
       polypeptide

<400>  18
gaggtgcagc tggtggagag cggcggcggc ctggtgcagc ccggcggcag cctgcgcctg       60

agctgcgccg ccagcggcta caccttcacc aactacggca tgaactgggt gcgccaggcc      120

cccggcaagg gcctggagtg ggtgggctgg atcaacacct acaccggcga gcccacctac      180

gccgccgact tcaagcgccg cttcaccttc agcctggaca ccagcaagag caccgcctac      240

ctgcagatga acagcctgcg cgccgaggac accgccgtgt actactgcgc caagtacccc      300

cactactacg gcagcagcca ctggtacttc gacgtgtggg gccagggcac cctggtgacc      360

gtgagcagcg ccagcaccaa gggccccagc gtgttccccc tggcccccag cagcaagagc      420

accagcggcg gcaccgccgc cctgggctgc ctggtgaagg actacttccc cgagcccgtg      480

accgtgagct ggaacagcgg cgccctgacc agcggcgtgc acaccttccc cgccgtgctg      540

cagagcagcg gcctgtacag cctgagcagc gtggtgaccg tgcccagcag cagcctgggc      600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag      660

gtggagccca agagctgcga caagacccac acctgccccc cctgccccgc ccccgagctg      720

ctgggcggcc ccagcgtgtt cctgttcccc cccaagccca aggacaccct gatgatcagc      780

cgcacccccg aggtgacctg cgtggtggtg gacgtgagcc acgaggaccc cgaggtgaag      840

ttcaactggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc ccgcgaggag      900

cagtacaaca gcacctaccg cgtggtgagc gtgctgaccg tgctgcacca ggactggctg      960

aacggcaagg agtacaagtg caaggtgagc aacaaggccc tgcccgcccc catcgagaag     1020

accatcagca aggccaaggg ccagccccgc gagccccagg tgtacaccct gccccccagc     1080

cgcgaggaga tgaccaagaa ccaggtgagc ctgacctgcc tggtgaaggg cttctacccc     1140

agcgacatcg ccgtggagtg ggagagcaac ggccagcccg agaacaacta caagaccacc     1200

ccccccgtgc tggacagcga cggcagcttc ttcctgtaca gcaagctgac cgtggacaag     1260

agccgctggc agcagggcaa cgtgttcagc tgcagcgtga tgcacgaggc cctgcacaac     1320

cactacaccc agaagagcct gagcctgagc cccggcaag                            1359


<210>  19
<211>  642
<212>  DNA
<213>  Unknown

<220>
<223>  Example polynucleotide sequence encoding Bevacizumab light chain 
       polypeptide

<400>  19
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga ccgcgtgacc       60

atcacctgca gcgccagcca ggacatcagc aactacctga actggtacca gcagaagccc      120

ggcaaggccc ccaaggtgct gatctacttc accagcagcc tgcacagcgg cgtgcccagc      180

cgcttcagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag tacagcaccg tgccctggac cttcggccag      300

ggcaccaagg tggagatcaa gcgcaccgtg gccgccccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc      600

ctgagcagcc ccgtgaccaa gagcttcaac cgcggcgagt gc                         642


<210>  20
<211>  29
<212>  RNA
<213>  Unknown

<220>
<223>  RNA sequence for pegatanib (RNA aptamer)

<400>  20
gcggaaucag ugaaugcuua uacauccgc                                         29


<210>  21
<211>  29
<212>  DNA
<213>  Unknown

<220>
<223>  example polynucleotide sequence encoding pegaptanib

<400>  21
cgccttagtc acttacgaat atgtaggcg                                         29


<210>  22
<211>  54
<212>  DNA
<213>  Unknown

<220>
<223>  Illustrative polynucleotide sequences encoding a CFH signal 
       peptide

<400>  22
atgagacttc tagcaaagat tatttgcctt atgttatggg ctatttgtgt agca             54


<210>  23
<211>  54
<212>  DNA
<213>  Unknown

<220>
<223>  Illustrative polynucleotide sequences encoding a CFH signal 
       peptide

<400>  23
atgagactgc tggccaagat catctgcctg atgctgtggg ccatctgcgt ggcc             54


<210>  24
<211>  54
<212>  DNA
<213>  Unknown

<220>
<223>  Illustrative polynucleotide sequences encoding a CFH signal 
       peptide

<400>  24
atgagactgc tcgccaagat catttgcctg atgctgtggg ccatctgcgt ggcc             54


<210>  25
<211>  54
<212>  DNA
<213>  Unknown

<220>
<223>  Illustrative polynucleotide sequences encoding a CFH signal 
       peptide

<400>  25
atgcggctgc tggccaagat catctgcctg atgctgtggg ccatctgcgt ggca             54


<210>  26
<211>  54
<212>  DNA
<213>  Unknown

<220>
<223>  Illustrative polynucleotide sequences encoding a CFH signal 
       peptide

<400>  26
atgcggctgc tcgccaagat catttgcctg atgctgtggg ccatctgcgt ggca             54


<210>  27
<211>  54
<212>  DNA
<213>  Unknown

<220>
<223>  Illustrative polynucleotide sequences encoding a CFH signal 
       peptide

<400>  27
atgagactgc tcgccaagat catctgtctg atgctgtggg ctatctgtgt cgct             54


<210>  28
<211>  54
<212>  DNA
<213>  Unknown

<220>
<223>  Illustrative polynucleotide sequences encoding a CFH signal 
       peptide

<400>  28
atgagactgc tcgccaagat catttgtctg atgctgtggg ctatctgtgt cgct             54


<210>  29
<211>  54
<212>  DNA
<213>  Unknown

<220>
<223>  Illustrative polynucleotide sequences encoding a CFH signal 
       peptide

<400>  29
atgcgcttgc tggcgaagat aatctgcctg atgttgtggg ccatatgcgt agcc             54


<210>  30
<211>  54
<212>  DNA
<213>  Unknown

<220>
<223>  Illustrative polynucleotide sequences encoding a CFH signal 
       peptide

<400>  30
atgcgcttgc tggcgaagat aatctgcctg atgttgtggg ccatatgcgt agcc             54


<210>  31
<211>  54
<212>  DNA
<213>  Unknown

<220>
<223>  Illustrative polynucleotide sequences encoding a CFH signal 
       peptide

<400>  31
atgcgcctgc tggccaagat catctgcctg atgctgtggg ccatctgcgt ggcc             54


<210>  32
<211>  583
<212>  PRT
<213>  Unknown

<220>
<223>  Complement Factor I

<400>  32

Met Lys Leu Leu His Val Phe Leu Leu Phe Leu Cys Phe His Leu Arg 
1               5                   10                  15      


Phe Cys Lys Val Thr Tyr Thr Ser Gln Glu Asp Leu Val Glu Lys Lys 
            20                  25                  30          


Cys Leu Ala Lys Lys Tyr Thr His Leu Ser Cys Asp Lys Val Phe Cys 
        35                  40                  45              


Gln Pro Trp Gln Arg Cys Ile Glu Gly Thr Cys Val Cys Lys Leu Pro 
    50                  55                  60                  


Tyr Gln Cys Pro Lys Asn Gly Thr Ala Val Cys Ala Thr Asn Arg Arg 
65                  70                  75                  80  


Ser Phe Pro Thr Tyr Cys Gln Gln Lys Ser Leu Glu Cys Leu His Pro 
                85                  90                  95      


Gly Thr Lys Phe Leu Asn Asn Gly Thr Cys Thr Ala Glu Gly Lys Phe 
            100                 105                 110         


Ser Val Ser Leu Lys His Gly Asn Thr Asp Ser Glu Gly Ile Val Glu 
        115                 120                 125             


Val Lys Leu Val Asp Gln Asp Lys Thr Met Phe Ile Cys Lys Ser Ser 
    130                 135                 140                 


Trp Ser Met Arg Glu Ala Asn Val Ala Cys Leu Asp Leu Gly Phe Gln 
145                 150                 155                 160 


Gln Gly Ala Asp Thr Gln Arg Arg Phe Lys Leu Ser Asp Leu Ser Ile 
                165                 170                 175     


Asn Ser Thr Glu Cys Leu His Val His Cys Arg Gly Leu Glu Thr Ser 
            180                 185                 190         


Leu Ala Glu Cys Thr Phe Thr Lys Arg Arg Thr Met Gly Tyr Gln Asp 
        195                 200                 205             


Phe Ala Asp Val Val Cys Tyr Thr Gln Lys Ala Asp Ser Pro Met Asp 
    210                 215                 220                 


Asp Phe Phe Gln Cys Val Asn Gly Lys Tyr Ile Ser Gln Met Lys Ala 
225                 230                 235                 240 


Cys Asp Gly Ile Asn Asp Cys Gly Asp Gln Ser Asp Glu Leu Cys Cys 
                245                 250                 255     


Lys Ala Cys Gln Gly Lys Gly Phe His Cys Lys Ser Gly Val Cys Ile 
            260                 265                 270         


Pro Ser Gln Tyr Gln Cys Asn Gly Glu Val Asp Cys Ile Thr Gly Glu 
        275                 280                 285             


Asp Glu Val Gly Cys Ala Gly Phe Ala Ser Val Thr Gln Glu Glu Thr 
    290                 295                 300                 


Glu Ile Leu Thr Ala Asp Met Asp Ala Glu Arg Arg Arg Ile Lys Ser 
305                 310                 315                 320 


Leu Leu Pro Lys Leu Ser Cys Gly Val Lys Asn Arg Met His Ile Arg 
                325                 330                 335     


Arg Lys Arg Ile Val Gly Gly Lys Arg Ala Gln Leu Gly Asp Leu Pro 
            340                 345                 350         


Trp Gln Val Ala Ile Lys Asp Ala Ser Gly Ile Thr Cys Gly Gly Ile 
        355                 360                 365             


Tyr Ile Gly Gly Cys Trp Ile Leu Thr Ala Ala His Cys Leu Arg Ala 
    370                 375                 380                 


Ser Lys Thr His Arg Tyr Gln Ile Trp Thr Thr Val Val Asp Trp Ile 
385                 390                 395                 400 


His Pro Asp Leu Lys Arg Ile Val Ile Glu Tyr Val Asp Arg Ile Ile 
                405                 410                 415     


Phe His Glu Asn Tyr Asn Ala Gly Thr Tyr Gln Asn Asp Ile Ala Leu 
            420                 425                 430         


Ile Glu Met Lys Lys Asp Gly Asn Lys Lys Asp Cys Glu Leu Pro Arg 
        435                 440                 445             


Ser Ile Pro Ala Cys Val Pro Trp Ser Pro Tyr Leu Phe Gln Pro Asn 
    450                 455                 460                 


Asp Thr Cys Ile Val Ser Gly Trp Gly Arg Glu Lys Asp Asn Glu Arg 
465                 470                 475                 480 


Val Phe Ser Leu Gln Trp Gly Glu Val Lys Leu Ile Ser Asn Cys Ser 
                485                 490                 495     


Lys Phe Tyr Gly Asn Arg Phe Tyr Glu Lys Glu Met Glu Cys Ala Gly 
            500                 505                 510         


Thr Tyr Asp Gly Ser Ile Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro 
        515                 520                 525             


Leu Val Cys Met Asp Ala Asn Asn Val Thr Tyr Val Trp Gly Val Val 
    530                 535                 540                 


Ser Trp Gly Glu Asn Cys Gly Lys Pro Glu Phe Pro Gly Val Tyr Thr 
545                 550                 555                 560 


Lys Val Ala Asn Tyr Phe Asp Trp Ile Ser Tyr His Val Gly Arg Pro 
                565                 570                 575     


Phe Ile Ser Gln Tyr Asn Val 
            580             


<210>  33
<211>  583
<212>  PRT
<213>  Unknown

<220>
<223>  Complement Factor I

<400>  33

Met Lys Leu Leu His Val Phe Leu Leu Phe Leu Cys Phe His Leu Arg 
1               5                   10                  15      


Phe Cys Lys Val Thr Tyr Thr Ser Gln Glu Asp Leu Val Glu Lys Lys 
            20                  25                  30          


Cys Leu Ala Lys Lys Tyr Thr His Leu Ser Cys Asp Lys Val Phe Cys 
        35                  40                  45              


Gln Pro Trp Gln Arg Cys Ile Glu Gly Thr Cys Val Cys Lys Leu Pro 
    50                  55                  60                  


Tyr Gln Cys Pro Lys Asn Gly Thr Ala Val Cys Ala Thr Asn Arg Arg 
65                  70                  75                  80  


Ser Phe Pro Thr Tyr Cys Gln Gln Lys Ser Leu Glu Cys Leu His Pro 
                85                  90                  95      


Gly Thr Lys Phe Leu Asn Asn Gly Thr Cys Thr Ala Glu Gly Lys Phe 
            100                 105                 110         


Ser Val Ser Leu Lys His Gly Asn Thr Asp Ser Glu Gly Ile Val Glu 
        115                 120                 125             


Val Lys Leu Val Asp Gln Asp Lys Thr Met Phe Ile Cys Lys Ser Ser 
    130                 135                 140                 


Trp Ser Met Arg Glu Ala Asn Val Ala Cys Leu Asp Leu Gly Phe Gln 
145                 150                 155                 160 


Gln Gly Ala Asp Thr Gln Arg Arg Phe Lys Leu Ser Asp Leu Ser Ile 
                165                 170                 175     


Asn Ser Thr Glu Cys Leu His Val His Cys Arg Gly Leu Glu Thr Ser 
            180                 185                 190         


Leu Ala Glu Cys Thr Phe Thr Lys Arg Arg Thr Met Gly Tyr Gln Asp 
        195                 200                 205             


Phe Ala Asp Val Val Cys Tyr Thr Gln Lys Ala Asp Ser Pro Met Asp 
    210                 215                 220                 


Asp Phe Phe Gln Cys Val Asn Gly Lys Tyr Ile Ser Gln Met Lys Ala 
225                 230                 235                 240 


Cys Asp Gly Ile Asn Asp Cys Gly Asp Gln Ser Asp Glu Leu Cys Cys 
                245                 250                 255     


Lys Ala Cys Gln Gly Lys Gly Phe His Cys Lys Ser Gly Val Cys Ile 
            260                 265                 270         


Pro Ser Gln Tyr Gln Cys Asn Gly Glu Val Asp Cys Ile Thr Gly Glu 
        275                 280                 285             


Asp Glu Val Gly Cys Ala Gly Phe Ala Ser Val Ala Gln Glu Glu Thr 
    290                 295                 300                 


Glu Ile Leu Thr Ala Asp Met Asp Ala Glu Arg Arg Arg Ile Lys Ser 
305                 310                 315                 320 


Leu Leu Pro Lys Leu Ser Cys Gly Val Lys Asn Arg Met His Ile Arg 
                325                 330                 335     


Arg Lys Arg Ile Val Gly Gly Lys Arg Ala Gln Leu Gly Asp Leu Pro 
            340                 345                 350         


Trp Gln Val Ala Ile Lys Asp Ala Ser Gly Ile Thr Cys Gly Gly Ile 
        355                 360                 365             


Tyr Ile Gly Gly Cys Trp Ile Leu Thr Ala Ala His Cys Leu Arg Ala 
    370                 375                 380                 


Ser Lys Thr His Arg Tyr Gln Ile Trp Thr Thr Val Val Asp Trp Ile 
385                 390                 395                 400 


His Pro Asp Leu Lys Arg Ile Val Ile Glu Tyr Val Asp Arg Ile Ile 
                405                 410                 415     


Phe His Glu Asn Tyr Asn Ala Gly Thr Tyr Gln Asn Asp Ile Ala Leu 
            420                 425                 430         


Ile Glu Met Lys Lys Asp Gly Asn Lys Lys Asp Cys Glu Leu Pro Arg 
        435                 440                 445             


Ser Ile Pro Ala Cys Val Pro Trp Ser Pro Tyr Leu Phe Gln Pro Asn 
    450                 455                 460                 


Asp Thr Cys Ile Val Ser Gly Trp Gly Arg Glu Lys Asp Asn Glu Arg 
465                 470                 475                 480 


Val Phe Ser Leu Gln Trp Gly Glu Val Lys Leu Ile Ser Asn Cys Ser 
                485                 490                 495     


Lys Phe Tyr Gly Asn Arg Phe Tyr Glu Lys Glu Met Glu Cys Ala Gly 
            500                 505                 510         


Thr Tyr Asp Gly Ser Ile Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro 
        515                 520                 525             


Leu Val Cys Met Asp Ala Asn Asn Val Thr Tyr Val Trp Gly Val Val 
    530                 535                 540                 


Ser Trp Gly Glu Asn Cys Gly Lys Pro Glu Phe Pro Gly Val Tyr Thr 
545                 550                 555                 560 


Lys Val Ala Asn Tyr Phe Asp Trp Ile Ser Tyr His Val Gly Arg Pro 
                565                 570                 575     


Phe Ile Ser Gln Tyr Asn Val 
            580             


<210>  34
<211>  1752
<212>  DNA
<213>  Unknown

<220>
<223>  wild type nucleotide sequence encoding Complement Factor I

<400>  34
atgaagcttc ttcatgtttt cctgttattt ctgtgcttcc acttaaggtt ttgcaaggtc       60

acttatacat ctcaagagga tctggtggag aaaaagtgct tagcaaaaaa atatactcac      120

ctctcctgcg ataaagtctt ctgccagcca tggcagagat gcattgaggg cacctgtgtt      180

tgtaaactac cgtatcagtg cccaaagaat ggcactgcag tgtgtgcaac taacaggaga      240

agcttcccaa catactgtca acaaaagagt ttggaatgtc ttcatccagg gacaaagttt      300

ttaaataacg gaacatgcac agccgaagga aagtttagtg tttccttgaa gcatggaaat      360

acagattcag agggaatagt tgaagtaaaa cttgtggacc aagataagac aatgttcata      420

tgcaaaagca gctggagcat gagggaagcc aacgtggcct gccttgacct tgggtttcaa      480

caaggtgctg atactcaaag aaggtttaag ttgtctgatc tctctataaa ttccactgaa      540

tgtctacatg tgcattgccg aggattagag accagtttgg ctgaatgtac ttttactaag      600

agaagaacta tgggttacca ggatttcgct gatgtggttt gttatacaca gaaagcagat      660

tctccaatgg atgacttctt tcagtgtgtg aatgggaaat acatttctca gatgaaagcc      720

tgtgatggta tcaatgattg tggagaccaa agtgatgaac tgtgttgtaa agcatgccaa      780

ggcaaaggct tccattgcaa atcgggtgtt tgcattccaa gccagtatca atgcaatggt      840

gaggtggact gcattacagg ggaagatgaa gttggctgtg caggctttgc atctgtggct      900

caagaagaaa cagaaatttt gactgctgac atggatgcag aaagaagacg gataaaatca      960

ttattaccta aactatcttg tggagttaaa aacagaatgc acattcgaag gaaacgaatt     1020

gtgggaggaa agcgagcaca actgggagac ctcccatggc aggtggcaat taaggatgcc     1080

agtggaatca cctgtggggg aatttatatt ggtggctgtt ggattctgac tgctgcacat     1140

tgtctcagag ccagtaaaac tcatcgttac caaatatgga caacagtagt agactggata     1200

caccccgacc ttaaacgtat agtaattgaa tacgtggata gaattatttt ccatgaaaac     1260

tacaatgcag gcacttacca aaatgacatc gctttgattg aaatgaaaaa agacggaaac     1320

aaaaaagatt gtgagctgcc tcgttccatc cctgcctgtg tcccctggtc tccttaccta     1380

ttccaaccta atgatacatg catcgtttct ggctggggac gagaaaaaga taacgaaaga     1440

gtcttttcac ttcagtgggg tgaagttaaa ctaataagca actgctctaa gttttacgga     1500

aatcgtttct atgaaaaaga aatggaatgt gcaggtacat atgatggttc catcgatgcc     1560

tgtaaagggg actctggagg ccccttagtc tgtatggatg ccaacaatgt gacttatgtc     1620

tggggtgttg tgagttgggg ggaaaactgt ggaaaaccag agttcccagg tgtttacacc     1680

aaagtggcca attattttga ctggattagc taccatgtag gaaggccttt tatttctcag     1740

tacaatgtat aa                                                         1752


<210>  35
<211>  1749
<212>  DNA
<213>  Unknown

<220>
<223>  preferred nucleotide sequence encoding Complement Factor I

<400>  35
atgaaactgc tgcatgtctt cctcctcttc ctgtgcttcc acctccgttt ctgtaaagtc       60

acctacacta gccaggagga tctggtggag aagaaatgcc tggccaagaa gtatacccac      120

ctgagctgcg acaaagtgtt ctgccagccc tggcaacgct gcattgaagg tacttgtgtg      180

tgcaagctgc cctaccagtg ccccaagaac ggcacggccg tgtgtgccac caacaggagg      240

agcttcccca cctactgcca gcagaagagc ctggaatgcc tccaccctgg caccaagttt      300

ctgaacaacg ggacctgcac agccgagggg aaattcagcg tctccctcaa gcacggcaat      360

acagactccg agggcattgt ggaagtgaag ctggtggacc aggacaagac catgttcatc      420

tgcaaaagca gctggtccat gcgggaggcc aatgtcgcct gcctggacct gggcttccag      480

cagggcgctg atacacagcg ccgctttaaa ctcagtgacc tcagcatcaa cagcactgag      540

tgtctgcacg tgcactgccg gggcctggag accagcctgg ctgagtgcac cttcaccaag      600

cgcaggacca tgggctacca ggattttgca gatgtggtct gctacaccca gaaggcagac      660

agccccatgg atgacttctt ccagtgtgtc aatggcaagt acatttccca gatgaaggct      720

tgtgacggga tcaatgattg cggggatcag agcgatgagc tctgctgcaa ggcctgccaa      780

gggaagggct ttcactgtaa gtctggggtg tgcatccctt ctcagtatca gtgcaacgga      840

gaggtggact gcatcactgg ggaggacgag gtgggctgtg ctggcttcgc ctctgtggcc      900

caggaggaga cagagatcct cacagctgac atggatgcag agcggcggcg catcaagagt      960

ctgctcccaa agctctcctg cggcgttaag aatcgcatgc acatccggag gaagcggatc     1020

gttggaggca aacgggctca gctgggggac ttgccgtggc aggtggccat caaagatgcc     1080

tccggaatca cctgtggtgg catctacatc ggcggctgct ggatcctgac cgccgcccac     1140

tgccttcggg ccagcaagac tcaccgctac cagatctgga ccaccgtggt ggattggatt     1200

caccccgacc tgaagaggat tgtcattgag tatgtcgacc gcatcatctt ccatgaaaac     1260

tacaatgccg ggacgtatca gaacgacatc gccctcatcg agatgaagaa ggatgggaac     1320

aagaaggact gtgagctgcc tcgctccatc cccgcctgtg taccatggtc tccgtacctg     1380

ttccagccaa atgacacatg catcgtgagc ggctggggcc gcgagaaaga caacgagagg     1440

gtcttctccc tgcagtgggg tgaagtcaag ctgatcagca actgctccaa gttctacggc     1500

aaccgcttct atgagaagga gatggagtgc gccggcacct atgacggcag cattgacgcg     1560

tgcaagggag acagtggggg ccccctggtc tgcatggacg ccaacaatgt gacctacgtg     1620

tggggagttg tgtcctgggg cgagaactgt ggcaagcctg agttcccggg cgtgtacaca     1680

aaggtggcaa actattttga ctggatctcc tatcacgttg gcaggccctt catttcacag     1740

tacaacgta                                                             1749


<210>  36
<211>  1752
<212>  DNA
<213>  Unknown

<220>
<223>  codon-optimised nucleotide sequence encoding Complement Factor I

<400>  36
atgaagctgc tgcatgtctt tctgctgttt ctgtgcttcc atctgcggtt ctgtaaagtg       60

acctatacta gccaggagga tctggtggag aagaagtgtc tggccaagaa gtacacacac      120

ctgagctgcg acaaggtgtt ctgtcagcct tggcagcggt gcatcgaggg cacctgcgtg      180

tgcaagctgc cttaccagtg cccaaagaac ggcaccgccg tgtgcgccac aaatcggaga      240

tcttttccaa catattgcca gcagaagagc ctggagtgtc tgcaccccgg caccaagttc      300

ctgaacaatg gcacctgcac agccgagggc aagttttctg tgagcctgaa gcacggcaac      360

acagatagcg agggcatcgt ggaggtgaag ctggtggacc aggataagac catgttcatc      420

tgtaagagct cctggtccat gagggaggca aacgtggcat gcctggatct gggattccag      480

cagggagcag acacacagag gcgctttaag ctgtccgacc tgtctatcaa tagcaccgag      540

tgcctgcacg tgcactgtag gggcctggag acatccctgg cagagtgcac cttcacaaag      600

cggagaacca tgggctacca ggactttgcc gacgtggtgt gctataccca gaaggccgat      660

agccccatgg acgatttctt tcagtgcgtg aacggcaagt atatctccca gatgaaggcc      720

tgcgacggca tcaatgactg tggcgatcag tctgacgagc tgtgctgtaa ggcctgtcag      780

ggcaagggct tccactgcaa gagcggcgtg tgcatccctt cccagtacca gtgcaacggc      840

gaggtggatt gtatcacagg agaggacgaa gtgggatgcg caggatttgc atctgtggca      900

caggaggaga cagagatcct gacagccgac atggatgccg agaggcgccg gatcaagtct      960

ctgctgccta agctgagctg tggcgtgaag aatcggatgc acatcagaag gaagcgcatc     1020

gtgggaggca agagggcaca gctgggcgat ctgccatggc aggtggccat caaggacgcc     1080

tctggcatca cctgcggcgg catctacatc ggaggatgtt ggatcctgac cgcagcacac     1140

tgcctgagag caagcaagac acacaggtat cagatctgga ccacagtggt ggattggatc     1200

cacccagacc tgaagagaat cgtgatcgag tacgtggata ggatcatctt tcacgagaac     1260

tacaatgccg gcacatatca gaacgacatc gccctgatcg agatgaagaa ggatggcaat     1320

aagaaggact gtgagctgcc cagatccatc cctgcatgcg tgccatggag cccctatctg     1380

ttccagccca acgatacctg catcgtgtcc ggatggggaa gggagaagga caatgagcgg     1440

gtgttttctc tgcagtgggg cgaggtgaag ctgatctcca actgttctaa gttctacggc     1500

aataggtttt atgagaagga gatggagtgc gccggcacct acgatggcag catcgacgcc     1560

tgtaagggcg attccggagg accactggtg tgcatggacg caaacaatgt gacatacgtg     1620

tggggagtgg tgtcctgggg agagaactgc ggcaagccag agttccccgg cgtatatacc     1680

aaggtggcca attattttga ttggatttcc taccacgtcg gcaggccctt tatttcccag     1740

tataatgtct aa                                                         1752


<210>  37
<211>  1231
<212>  PRT
<213>  Unknown

<220>
<223>  Complement Factor H

<400>  37

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     


Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         


Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             


Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 


Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 


Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     


His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         


Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             


Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 


Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 


Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     


His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         


Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             


Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 


Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 


Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     


Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         


Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             


Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 


Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 


Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     


His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         


Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             


Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 


Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 


Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     


Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         


Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             


Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu 
    690                 695                 700                 


Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser 
705                 710                 715                 720 


Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly 
                725                 730                 735     


Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys 
            740                 745                 750         


Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys 
        755                 760                 765             


Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys 
    770                 775                 780                 


Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu 
785                 790                 795                 800 


Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln 
                805                 810                 815     


Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly 
            820                 825                 830         


Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly 
        835                 840                 845             


Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys 
    850                 855                 860                 


Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr 
865                 870                 875                 880 


Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys 
                885                 890                 895     


Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu 
            900                 905                 910         


Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly 
        915                 920                 925             


Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His 
    930                 935                 940                 


Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe 
945                 950                 955                 960 


Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu 
                965                 970                 975     


Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu 
            980                 985                 990         


Pro Ser Phe Glu Asn Ala Ile Pro  Met Gly Glu Lys Lys  Asp Val Tyr 
        995                 1000                 1005             


Lys Ala  Gly Glu Gln Val Thr  Tyr Thr Cys Ala Thr  Tyr Tyr Lys 
    1010                 1015                 1020             


Met Asp  Gly Ala Ser Asn Val  Thr Cys Ile Asn Ser  Arg Trp Thr 
    1025                 1030                 1035             


Gly Arg  Pro Thr Cys Arg Asp  Thr Ser Cys Val Asn  Pro Pro Thr 
    1040                 1045                 1050             


Val Gln  Asn Ala Tyr Ile Val  Ser Arg Gln Met Ser  Lys Tyr Pro 
    1055                 1060                 1065             


Ser Gly  Glu Arg Val Arg Tyr  Gln Cys Arg Ser Pro  Tyr Glu Met 
    1070                 1075                 1080             


Phe Gly  Asp Glu Glu Val Met  Cys Leu Asn Gly Asn  Trp Thr Glu 
    1085                 1090                 1095             


Pro Pro  Gln Cys Lys Asp Ser  Thr Gly Lys Cys Gly  Pro Pro Pro 
    1100                 1105                 1110             


Pro Ile  Asp Asn Gly Asp Ile  Thr Ser Phe Pro Leu  Ser Val Tyr 
    1115                 1120                 1125             


Ala Pro  Ala Ser Ser Val Glu  Tyr Gln Cys Gln Asn  Leu Tyr Gln 
    1130                 1135                 1140             


Leu Glu  Gly Asn Lys Arg Ile  Thr Cys Arg Asn Gly  Gln Trp Ser 
    1145                 1150                 1155             


Glu Pro  Pro Lys Cys Leu His  Pro Cys Val Ile Ser  Arg Glu Ile 
    1160                 1165                 1170             


Met Glu  Asn Tyr Asn Ile Ala  Leu Arg Trp Thr Ala  Lys Gln Lys 
    1175                 1180                 1185             


Leu Tyr  Ser Arg Thr Gly Glu  Ser Val Glu Phe Val  Cys Lys Arg 
    1190                 1195                 1200             


Gly Tyr  Arg Leu Ser Ser Arg  Ser His Thr Leu Arg  Thr Thr Cys 
    1205                 1210                 1215             


Trp Asp  Gly Lys Leu Glu Tyr  Pro Thr Cys Ala Lys  Arg 
    1220                 1225                 1230     


<210>  38
<211>  3696
<212>  DNA
<213>  Unknown

<220>
<223>  nucleotide sequence encoding Complement Factor H

<400>  38
atgagacttc tagcaaagat tatttgcctt atgttatggg ctatttgtgt agcagaagat       60

tgcaatgaac ttcctccaag aagaaataca gaaattctga caggttcctg gtctgaccaa      120

acatatccag aaggcaccca ggctatctat aaatgccgcc ctggatatag atctcttgga      180

aatgtaataa tggtatgcag gaagggagaa tgggttgctc ttaatccatt aaggaaatgt      240

cagaaaaggc cctgtggaca tcctggagat actccttttg gtacttttac ccttacagga      300

ggaaatgtgt ttgaatatgg tgtaaaagct gtgtatacat gtaatgaggg gtatcaattg      360

ctaggtgaga ttaattaccg tgaatgtgac acagatggat ggaccaatga tattcctata      420

tgtgaagttg tgaagtgttt accagtgaca gcaccagaga atggaaaaat tgtcagtagt      480

gcaatggaac cagatcggga ataccatttt ggacaagcag tacggtttgt atgtaactca      540

ggctacaaga ttgaaggaga tgaagaaatg cattgttcag acgatggttt ttggagtaaa      600

gagaaaccaa agtgtgtgga aatttcatgc aaatccccag atgttataaa tggatctcct      660

atatctcaga agattattta taaggagaat gaacgatttc aatataaatg taacatgggt      720

tatgaataca gtgaaagagg agatgctgta tgcactgaat ctggatggcg tccgttgcct      780

tcatgtgaag aaaaatcatg tgataatcct tatattccaa atggtgacta ctcaccttta      840

aggattaaac acagaactgg agatgaaatc acgtaccagt gtagaaatgg tttttatcct      900

gcaacccggg gaaatacagc aaaatgcaca agtactggct ggatacctgc tccgagatgt      960

accttgaaac cttgtgatta tccagacatt aaacatggag gtctatatca tgagaatatg     1020

cgtagaccat actttccagt agctgtagga aaatattact cctattactg tgatgaacat     1080

tttgagactc cgtcaggaag ttactgggat cacattcatt gcacacaaga tggatggtcg     1140

ccagcagtac catgcctcag aaaatgttat tttccttatt tggaaaatgg atataatcaa     1200

aatcatggaa gaaagtttgt acagggtaaa tctatagacg ttgcctgcca tcctggctac     1260

gctcttccaa aagcgcagac cacagttaca tgtatggaga atggctggtc tcctactccc     1320

agatgcatcc gtgtcaaaac atgttccaaa tcaagtatag atattgagaa tgggtttatt     1380

tctgaatctc agtatacata tgccttaaaa gaaaaagcga aatatcaatg caaactagga     1440

tatgtaacag cagatggtga aacatcagga tcaattacat gtgggaaaga tggatggtca     1500

gctcaaccca cgtgcattaa atcttgtgat atcccagtat ttatgaatgc cagaactaaa     1560

aatgacttca catggtttaa gctgaatgac acattggact atgaatgcca tgatggttat     1620

gaaagcaata ctggaagcac cactggttcc atagtgtgtg gttacaatgg ttggtctgat     1680

ttacccatat gttatgaaag agaatgcgaa cttcctaaaa tagatgtaca cttagttcct     1740

gatcgcaaga aagaccagta taaagttgga gaggtgttga aattctcctg caaaccagga     1800

tttacaatag ttggacctaa ttccgttcag tgctaccact ttggattgtc tcctgacctc     1860

ccaatatgta aagagcaagt acaatcatgt ggtccacctc ctgaactcct caatgggaat     1920

gttaaggaaa aaacgaaaga agaatatgga cacagtgaag tggtggaata ttattgcaat     1980

cctagatttc taatgaaggg acctaataaa attcaatgtg ttgatggaga gtggacaact     2040

ttaccagtgt gtattgtgga ggagagtacc tgtggagata tacctgaact tgaacatggc     2100

tgggcccagc tttcttcccc tccttattac tatggagatt cagtggaatt caattgctca     2160

gaatcattta caatgattgg acacagatca attacgtgta ttcatggagt atggacccaa     2220

cttccccagt gtgtggcaat agataaactt aagaagtgca aatcatcaaa tttaattata     2280

cttgaggaac atttaaaaaa caagaaggaa ttcgatcata attctaacat aaggtacaga     2340

tgtagaggaa aagaaggatg gatacacaca gtctgcataa atggaagatg ggatccagaa     2400

gtgaactgct caatggcaca aatacaatta tgcccacctc cacctcagat tcccaattct     2460

cacaatatga caaccacact gaattatcgg gatggagaaa aagtatctgt tctttgccaa     2520

gaaaattatc taattcagga aggagaagaa attacatgca aagatggaag atggcagtca     2580

ataccactct gtgttgaaaa aattccatgt tcacaaccac ctcagataga acacggaacc     2640

attaattcat ccaggtcttc acaagaaagt tatgcacatg ggactaaatt gagttatact     2700

tgtgagggtg gtttcaggat atctgaagaa aatgaaacaa catgctacat gggaaaatgg     2760

agttctccac ctcagtgtga aggccttcct tgtaaatctc cacctgagat ttctcatggt     2820

gttgtagctc acatgtcaga cagttatcag tatggagaag aagttacgta caaatgtttt     2880

gaaggttttg gaattgatgg gcctgcaatt gcaaaatgct taggagaaaa atggtctcac     2940

cctccatcat gcataaaaac agattgtctc agtttaccta gctttgaaaa tgccataccc     3000

atgggagaga agaaggatgt gtataaggcg ggtgagcaag tgacttacac ttgtgcaaca     3060

tattacaaaa tggatggagc cagtaatgta acatgcatta atagcagatg gacaggaagg     3120

ccaacatgca gagacacctc ctgtgtgaat ccgcccacag tacaaaatgc ttatatagtg     3180

tcgagacaga tgagtaaata tccatctggt gagagagtac gttatcaatg taggagccct     3240

tatgaaatgt ttggggatga agaagtgatg tgtttaaatg gaaactggac ggaaccacct     3300

caatgcaaag attctacagg aaaatgtggg ccccctccac ctattgacaa tggggacatt     3360

acttcattcc cgttgtcagt atatgctcca gcttcatcag ttgagtacca atgccagaac     3420

ttgtatcaac ttgagggtaa caagcgaata acatgtagaa atggacaatg gtcagaacca     3480

ccaaaatgct tacatccgtg tgtaatatcc cgagaaatta tggaaaatta taacatagca     3540

ttaaggtgga cagccaaaca gaagctttat tcgagaacag gtgaatcagt tgaatttgtg     3600

tgtaaacggg gatatcgtct ttcatcacgt tctcacacat tgcgaacaac atgttgggat     3660

gggaaactgg agtatccaac ttgtgcaaaa agatag                               3696


<210>  39
<211>  449
<212>  PRT
<213>  Unknown

<220>
<223>  FHL1

<400>  39

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Ile Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     


Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         


Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             


Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 


Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 


Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     


His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         


Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             


Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 


Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 


Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     


His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         


Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Ser Phe Thr 
        435                 440                 445             


Leu 
    


<210>  40
<211>  1350
<212>  DNA
<213>  Unknown

<220>
<223>  example nucleotide sequence encoding FHL1

<400>  40
atgagacttc tagcaaagat tatttgcctt atgttatggg ctatttgtgt agcagaagat       60

tgcaatgaac ttcctccaag aagaaataca gaaattctga caggttcctg gtctgaccaa      120

acatatccag aaggcaccca ggctatctat aaatgccgcc ctggatatag atctcttgga      180

aatataataa tggtatgcag gaagggagaa tgggttgctc ttaatccatt aaggaaatgt      240

cagaaaaggc cctgtggaca tcctggagat actccttttg gtacttttac ccttacagga      300

ggaaatgtgt ttgaatatgg tgtaaaagct gtgtatacat gtaatgaggg gtatcaattg      360

ctaggtgaga ttaattaccg tgaatgtgac acagatggat ggaccaatga tattcctata      420

tgtgaagttg tgaagtgttt accagtgaca gcaccagaga atggaaaaat tgtcagtagt      480

gcaatggaac cagatcggga ataccatttt ggacaagcag tacggtttgt atgtaactca      540

ggctacaaga ttgaaggaga tgaagaaatg cattgttcag acgatggttt ttggagtaaa      600

gagaaaccaa agtgtgtgga aatttcatgc aaatccccag atgttataaa tggatctcct      660

atatctcaga agattattta taaggagaat gaacgatttc aatataaatg taacatgggt      720

tatgaataca gtgaaagagg agatgctgta tgcactgaat ctggatggcg tccgttgcct      780

tcatgtgaag aaaaatcatg tgataatcct tatattccaa atggtgacta ctcaccttta      840

aggattaaac acagaactgg agatgaaatc acgtaccagt gtagaaatgg tttttatcct      900

gcaacccggg gaaatacagc aaaatgcaca agtactggct ggatacctgc tccgagatgt      960

accttgaaac cttgtgatta tccagacatt aaacatggag gtctatatca tgagaatatg     1020

cgtagaccat actttccagt agctgtagga aaatattact cctattactg tgatgaacat     1080

tttgagactc cgtcaggaag ttactgggat cacattcatt gcacacaaga tggatggtcg     1140

ccagcagtac catgcctcag aaaatgttat tttccttatt tggaaaatgg atataatcaa     1200

aattatggaa gaaagtttgt acagggtaaa tctatagacg ttgcctgcca tcctggctac     1260

gctcttccaa aagcgcagac cacagttaca tgtatggaga atggctggtc tcctactccc     1320

agatgcatcc gtgtcagctt taccctctga                                      1350


<210>  41
<211>  1347
<212>  DNA
<213>  Unknown

<220>
<223>  preferred nucleotide sequence encoding FHL1

<400>  41
atgcgcctcc tggccaagat catctgcctc atgctgtggg ccatctgcgt ggctgaggac       60

tgcaatgagc tgccgcccag gaggaacaca gagatcctga cagggagctg gtctgaccag      120

acctaccctg agggcaccca ggcgatctac aagtgccggc cgggctacag gagcctgggg      180

aacatcatca tggtgtgtag aaagggcgaa tgggtggccc tcaaccccct gaggaagtgc      240

cagaagcggc cctgtggcca ccccggggac acacccttcg ggaccttcac cctgaccggc      300

ggcaatgtgt ttgagtacgg cgtgaaggct gtctacacat gcaacgaggg gtaccagctg      360

ctgggcgaga ttaactaccg ggagtgtgac accgatgggt ggaccaacga cattcccatc      420

tgtgaggtgg tcaagtgtct ccccgtgaca gccccagaaa atggcaaaat cgtgagcagc      480

gccatggagc ctgaccgcga atatcacttt gggcaggccg tgaggtttgt gtgcaactcg      540

ggctacaaaa ttgaaggtga tgaggagatg cactgcagcg atgatggctt ctggtccaag      600

gagaagccca aatgtgtgga gatctcctgc aagtctcccg acgtgatcaa cggcagccca      660

atcagccaga agattattta caaagagaac gagcgcttcc agtacaagtg taacatgggc      720

tatgagtatt cagagagggg agatgccgtc tgcactgaga gcggctggag accactgcct      780

agctgcgagg aaaagagttg tgacaaccct tacatcccaa atggcgacta ctcccctctg      840

cggatcaaac accggaccgg ggatgaaatc acctatcagt gccgcaatgg attctacccg      900

gccacccgcg gcaacaccgc caaatgcacc agcacaggct ggatccccgc cccccgctgt      960

acgctgaagc cttgcgacta tccagacatc aagcacggag gcctgtacca cgaaaacatg     1020

cggcggcctt atttccctgt ggcagtgggg aagtactaca gctactactg cgacgagcac     1080

ttcgagaccc cctctggctc ctactgggac cacatccact gcacacagga cggctggtct     1140

ccagctgtgc cctgcctgag gaaatgctac ttcccctacc tggagaacgg atacaaccag     1200

aactatggcc gcaagttcgt gcagggcaag agcatcgatg tggcctgcca ccctggctac     1260

gccctgccca aggcccagac aactgtgacc tgcatggaga atggttggag ccccaccccg     1320

cgctgcatcc gggtgtcctt cacgctc                                         1347


<210>  42
<211>  2038
<212>  PRT
<213>  Unknown

<220>
<223>  CR1

<400>  42

Met Gly Ala Ser Ser Pro Arg Ser Pro Glu Pro Val Gly Pro Pro Ala 
1               5                   10                  15      


Pro Gly Leu Pro Phe Cys Cys Gly Gly Ser Leu Leu Ala Val Val Val 
            20                  25                  30          


Leu Leu Ala Leu Pro Val Ala Trp Gly Gln Cys Asn Ala Pro Glu Trp 
        35                  40                  45              


Leu Pro Phe Ala Arg Pro Thr Asn Leu Thr Asp Glu Phe Glu Phe Pro 
    50                  55                  60                  


Ile Gly Thr Tyr Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Ser Gly Arg 
65                  70                  75                  80  


Pro Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Thr Gly Ala Lys 
                85                  90                  95      


Asp Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn 
            100                 105                 110         


Gly Met Val His Val Ile Lys Gly Ile Gln Phe Gly Ser Gln Ile Lys 
        115                 120                 125             


Tyr Ser Cys Thr Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Thr 
    130                 135                 140                 


Cys Ile Ile Ser Gly Asp Thr Val Ile Trp Asp Asn Glu Thr Pro Ile 
145                 150                 155                 160 


Cys Asp Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Thr Asn Gly Asp 
                165                 170                 175     


Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr 
            180                 185                 190         


Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val 
        195                 200                 205             


Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile 
    210                 215                 220                 


Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro 
225                 230                 235                 240 


Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe 
                245                 250                 255     


Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met 
            260                 265                 270         


Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro 
        275                 280                 285             


Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu 
    290                 295                 300                 


His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln 
305                 310                 315                 320 


Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala 
                325                 330                 335     


Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Thr 
            340                 345                 350         


Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn Gly 
        355                 360                 365             


Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp Phe 
    370                 375                 380                 


Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys 
385                 390                 395                 400 


Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys 
                405                 410                 415     


Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg His 
            420                 425                 430         


Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Thr Val Asn Tyr 
        435                 440                 445             


Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu Ile Gly 
    450                 455                 460                 


Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly Val Trp 
465                 470                 475                 480 


Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln Ala Pro 
                485                 490                 495     


Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp 
            500                 505                 510         


Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr 
        515                 520                 525             


Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp Ser Ser 
    530                 535                 540                 


Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro 
545                 550                 555                 560 


Val Asn Gly Met Val His Val Ile Thr Asp Ile Gln Val Gly Ser Arg 
                565                 570                 575     


Ile Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly His Ser Ala 
            580                 585                 590         


Glu Cys Ile Leu Ser Gly Asn Ala Ala His Trp Ser Thr Lys Pro Pro 
        595                 600                 605             


Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn Gly 
    610                 615                 620                 


Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val 
625                 630                 635                 640 


Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu 
                645                 650                 655     


Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly 
            660                 665                 670         


Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr 
        675                 680                 685             


Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu 
    690                 695                 700                 


Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val 
705                 710                 715                 720 


Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu 
                725                 730                 735     


Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val 
            740                 745                 750         


Leu His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly 
        755                 760                 765             


Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala 
    770                 775                 780                 


Ala Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro 
785                 790                 795                 800 


Thr Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn 
                805                 810                 815     


Gly Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp 
            820                 825                 830         


Phe Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr 
        835                 840                 845             


Cys Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val 
    850                 855                 860                 


Cys Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg 
865                 870                 875                 880 


His Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Ala Val Asn 
                885                 890                 895     


Tyr Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu Ile 
            900                 905                 910         


Gly Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly Val 
        915                 920                 925             


Trp Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln Ala 
    930                 935                 940                 


Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala Ser 
945                 950                 955                 960 


Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr 
                965                 970                 975     


Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp Ser 
            980                 985                 990         


Ser Pro Lys Asp Val Cys Lys Arg  Lys Ser Cys Lys Thr  Pro Pro Asp 
        995                 1000                 1005             


Pro Val  Asn Gly Met Val His  Val Ile Thr Asp Ile  Gln Val Gly 
    1010                 1015                 1020             


Ser Arg  Ile Asn Tyr Ser Cys  Thr Thr Gly His Arg  Leu Ile Gly 
    1025                 1030                 1035             


His Ser  Ser Ala Glu Cys Ile  Leu Ser Gly Asn Thr  Ala His Trp 
    1040                 1045                 1050             


Ser Thr  Lys Pro Pro Ile Cys  Gln Arg Ile Pro Cys  Gly Leu Pro 
    1055                 1060                 1065             


Pro Thr  Ile Ala Asn Gly Asp  Phe Ile Ser Thr Asn  Arg Glu Asn 
    1070                 1075                 1080             


Phe His  Tyr Gly Ser Val Val  Thr Tyr Arg Cys Asn  Leu Gly Ser 
    1085                 1090                 1095             


Arg Gly  Arg Lys Val Phe Glu  Leu Val Gly Glu Pro  Ser Ile Tyr 
    1100                 1105                 1110             


Cys Thr  Ser Asn Asp Asp Gln  Val Gly Ile Trp Ser  Gly Pro Ala 
    1115                 1120                 1125             


Pro Gln  Cys Ile Ile Pro Asn  Lys Cys Thr Pro Pro  Asn Val Glu 
    1130                 1135                 1140             


Asn Gly  Ile Leu Val Ser Asp  Asn Arg Ser Leu Phe  Ser Leu Asn 
    1145                 1150                 1155             


Glu Val  Val Glu Phe Arg Cys  Gln Pro Gly Phe Val  Met Lys Gly 
    1160                 1165                 1170             


Pro Arg  Arg Val Lys Cys Gln  Ala Leu Asn Lys Trp  Glu Pro Glu 
    1175                 1180                 1185             


Leu Pro  Ser Cys Ser Arg Val  Cys Gln Pro Pro Pro  Glu Ile Leu 
    1190                 1195                 1200             


His Gly  Glu His Thr Pro Ser  His Gln Asp Asn Phe  Ser Pro Gly 
    1205                 1210                 1215             


Gln Glu  Val Phe Tyr Ser Cys  Glu Pro Gly Tyr Asp  Leu Arg Gly 
    1220                 1225                 1230             


Ala Ala  Ser Leu His Cys Thr  Pro Gln Gly Asp Trp  Ser Pro Glu 
    1235                 1240                 1245             


Ala Pro  Arg Cys Ala Val Lys  Ser Cys Asp Asp Phe  Leu Gly Gln 
    1250                 1255                 1260             


Leu Pro  His Gly Arg Val Leu  Phe Pro Leu Asn Leu  Gln Leu Gly 
    1265                 1270                 1275             


Ala Lys  Val Ser Phe Val Cys  Asp Glu Gly Phe Arg  Leu Lys Gly 
    1280                 1285                 1290             


Ser Ser  Val Ser His Cys Val  Leu Val Gly Met Arg  Ser Leu Trp 
    1295                 1300                 1305             


Asn Asn  Ser Val Pro Val Cys  Glu His Ile Phe Cys  Pro Asn Pro 
    1310                 1315                 1320             


Pro Ala  Ile Leu Asn Gly Arg  His Thr Gly Thr Pro  Ser Gly Asp 
    1325                 1330                 1335             


Ile Pro  Tyr Gly Lys Glu Ile  Ser Tyr Thr Cys Asp  Pro His Pro 
    1340                 1345                 1350             


Asp Arg  Gly Met Thr Phe Asn  Leu Ile Gly Glu Ser  Thr Ile Arg 
    1355                 1360                 1365             


Cys Thr  Ser Asp Pro His Gly  Asn Gly Val Trp Ser  Ser Pro Ala 
    1370                 1375                 1380             


Pro Arg  Cys Glu Leu Ser Val  Arg Ala Gly His Cys  Lys Thr Pro 
    1385                 1390                 1395             


Glu Gln  Phe Pro Phe Ala Ser  Pro Thr Ile Pro Ile  Asn Asp Phe 
    1400                 1405                 1410             


Glu Phe  Pro Val Gly Thr Ser  Leu Asn Tyr Glu Cys  Arg Pro Gly 
    1415                 1420                 1425             


Tyr Phe  Gly Lys Met Phe Ser  Ile Ser Cys Leu Glu  Asn Leu Val 
    1430                 1435                 1440             


Trp Ser  Ser Val Glu Asp Asn  Cys Arg Arg Lys Ser  Cys Gly Pro 
    1445                 1450                 1455             


Pro Pro  Glu Pro Phe Asn Gly  Met Val His Ile Asn  Thr Asp Thr 
    1460                 1465                 1470             


Gln Phe  Gly Ser Thr Val Asn  Tyr Ser Cys Asn Glu  Gly Phe Arg 
    1475                 1480                 1485             


Leu Ile  Gly Ser Pro Ser Thr  Thr Cys Leu Val Ser  Gly Asn Asn 
    1490                 1495                 1500             


Val Thr  Trp Asp Lys Lys Ala  Pro Ile Cys Glu Ile  Ile Ser Cys 
    1505                 1510                 1515             


Glu Pro  Pro Pro Thr Ile Ser  Asn Gly Asp Phe Tyr  Ser Asn Asn 
    1520                 1525                 1530             


Arg Thr  Ser Phe His Asn Gly  Thr Val Val Thr Tyr  Gln Cys His 
    1535                 1540                 1545             


Thr Gly  Pro Asp Gly Glu Gln  Leu Phe Glu Leu Val  Gly Glu Arg 
    1550                 1555                 1560             


Ser Ile  Tyr Cys Thr Ser Lys  Asp Asp Gln Val Gly  Val Trp Ser 
    1565                 1570                 1575             


Ser Pro  Pro Pro Arg Cys Ile  Ser Thr Asn Lys Cys  Thr Ala Pro 
    1580                 1585                 1590             


Glu Val  Glu Asn Ala Ile Arg  Val Pro Gly Asn Arg  Ser Phe Phe 
    1595                 1600                 1605             


Ser Leu  Thr Glu Ile Ile Arg  Phe Arg Cys Gln Pro  Gly Phe Val 
    1610                 1615                 1620             


Met Val  Gly Ser His Thr Val  Gln Cys Gln Thr Asn  Gly Arg Trp 
    1625                 1630                 1635             


Gly Pro  Lys Leu Pro His Cys  Ser Arg Val Cys Gln  Pro Pro Pro 
    1640                 1645                 1650             


Glu Ile  Leu His Gly Glu His  Thr Leu Ser His Gln  Asp Asn Phe 
    1655                 1660                 1665             


Ser Pro  Gly Gln Glu Val Phe  Tyr Ser Cys Glu Pro  Ser Tyr Asp 
    1670                 1675                 1680             


Leu Arg  Gly Ala Ala Ser Leu  His Cys Thr Pro Gln  Gly Asp Trp 
    1685                 1690                 1695             


Ser Pro  Glu Ala Pro Arg Cys  Thr Val Lys Ser Cys  Asp Asp Phe 
    1700                 1705                 1710             


Leu Gly  Gln Leu Pro His Gly  Arg Val Leu Leu Pro  Leu Asn Leu 
    1715                 1720                 1725             


Gln Leu  Gly Ala Lys Val Ser  Phe Val Cys Asp Glu  Gly Phe Arg 
    1730                 1735                 1740             


Leu Lys  Gly Arg Ser Ala Ser  His Cys Val Leu Ala  Gly Met Lys 
    1745                 1750                 1755             


Ala Leu  Trp Asn Ser Ser Val  Pro Val Cys Glu Gln  Ile Phe Cys 
    1760                 1765                 1770             


Pro Asn  Pro Pro Ala Ile Leu  Asn Gly Arg His Thr  Gly Thr Pro 
    1775                 1780                 1785             


Phe Gly  Asp Ile Pro Tyr Gly  Lys Glu Ile Ser Tyr  Ala Cys Asp 
    1790                 1795                 1800             


Thr His  Pro Asp Arg Gly Met  Thr Phe Asn Leu Ile  Gly Glu Ser 
    1805                 1810                 1815             


Ser Ile  Arg Cys Thr Ser Asp  Pro Gln Gly Asn Gly  Val Trp Ser 
    1820                 1825                 1830             


Ser Pro  Ala Pro Arg Cys Glu  Leu Ser Val Pro Ala  Ala Cys Pro 
    1835                 1840                 1845             


His Pro  Pro Lys Ile Gln Asn  Gly His Tyr Ile Gly  Gly His Val 
    1850                 1855                 1860             


Ser Leu  Tyr Leu Pro Gly Met  Thr Ile Ser Tyr Ile  Cys Asp Pro 
    1865                 1870                 1875             


Gly Tyr  Leu Leu Val Gly Lys  Gly Phe Ile Phe Cys  Thr Asp Gln 
    1880                 1885                 1890             


Gly Ile  Trp Ser Gln Leu Asp  His Tyr Cys Lys Glu  Val Asn Cys 
    1895                 1900                 1905             


Ser Phe  Pro Leu Phe Met Asn  Gly Ile Ser Lys Glu  Leu Glu Met 
    1910                 1915                 1920             


Lys Lys  Val Tyr His Tyr Gly  Asp Tyr Val Thr Leu  Lys Cys Glu 
    1925                 1930                 1935             


Asp Gly  Tyr Thr Leu Glu Gly  Ser Pro Trp Ser Gln  Cys Gln Ala 
    1940                 1945                 1950             


Asp Asp  Arg Trp Asp Pro Pro  Leu Ala Lys Cys Thr  Ser Arg Thr 
    1955                 1960                 1965             


His Asp  Ala Leu Ile Val Gly  Thr Leu Ser Gly Thr  Ile Phe Phe 
    1970                 1975                 1980             


Ile Leu  Leu Ile Ile Phe Leu  Ser Trp Ile Ile Leu  Lys His Arg 
    1985                 1990                 1995             


Lys Gly  Asn Asn Ala His Glu  Asn Pro Lys Glu Val  Ala Ile His 
    2000                 2005                 2010             


Leu His  Ser Gln Gly Gly Ser  Ser Val His Pro Arg  Thr Leu Gln 
    2015                 2020                 2025             


Thr Asn  Glu Glu Asn Ser Arg  Val Leu Pro 
    2030                 2035             


<210>  43
<211>  392
<212>  PRT
<213>  Unknown

<220>
<223>  MCP

<400>  43

Met Glu Pro Pro Gly Arg Arg Glu Cys Pro Phe Pro Ser Trp Arg Phe 
1               5                   10                  15      


Pro Gly Leu Leu Leu Ala Ala Met Val Leu Leu Leu Tyr Ser Phe Ser 
            20                  25                  30          


Asp Ala Cys Glu Glu Pro Pro Thr Phe Glu Ala Met Glu Leu Ile Gly 
        35                  40                  45              


Lys Pro Lys Pro Tyr Tyr Glu Ile Gly Glu Arg Val Asp Tyr Lys Cys 
    50                  55                  60                  


Lys Lys Gly Tyr Phe Tyr Ile Pro Pro Leu Ala Thr His Thr Ile Cys 
65                  70                  75                  80  


Asp Arg Asn His Thr Trp Leu Pro Val Ser Asp Asp Ala Cys Tyr Arg 
                85                  90                  95      


Glu Thr Cys Pro Tyr Ile Arg Asp Pro Leu Asn Gly Gln Ala Val Pro 
            100                 105                 110         


Ala Asn Gly Thr Tyr Glu Phe Gly Tyr Gln Met His Phe Ile Cys Asn 
        115                 120                 125             


Glu Gly Tyr Tyr Leu Ile Gly Glu Glu Ile Leu Tyr Cys Glu Leu Lys 
    130                 135                 140                 


Gly Ser Val Ala Ile Trp Ser Gly Lys Pro Pro Ile Cys Glu Lys Val 
145                 150                 155                 160 


Leu Cys Thr Pro Pro Pro Lys Ile Lys Asn Gly Lys His Thr Phe Ser 
                165                 170                 175     


Glu Val Glu Val Phe Glu Tyr Leu Asp Ala Val Thr Tyr Ser Cys Asp 
            180                 185                 190         


Pro Ala Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser Thr Ile 
        195                 200                 205             


Tyr Cys Gly Asp Asn Ser Val Trp Ser Arg Ala Ala Pro Glu Cys Lys 
    210                 215                 220                 


Val Val Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys Gln Ile Ser 
225                 230                 235                 240 


Gly Phe Gly Lys Lys Phe Tyr Tyr Lys Ala Thr Val Met Phe Glu Cys 
                245                 250                 255     


Asp Lys Gly Phe Tyr Leu Asp Gly Ser Asp Thr Ile Val Cys Asp Ser 
            260                 265                 270         


Asn Ser Thr Trp Asp Pro Pro Val Pro Lys Cys Leu Lys Val Leu Pro 
        275                 280                 285             


Pro Ser Ser Thr Lys Pro Pro Ala Leu Ser His Ser Val Ser Thr Ser 
    290                 295                 300                 


Ser Thr Thr Lys Ser Pro Ala Ser Ser Ala Ser Gly Pro Arg Pro Thr 
305                 310                 315                 320 


Tyr Lys Pro Pro Val Ser Asn Tyr Pro Gly Tyr Pro Lys Pro Glu Glu 
                325                 330                 335     


Gly Ile Leu Asp Ser Leu Asp Val Trp Val Ile Ala Val Ile Val Ile 
            340                 345                 350         


Ala Ile Val Val Gly Val Ala Val Ile Cys Val Val Pro Tyr Arg Tyr 
        355                 360                 365             


Leu Gln Arg Arg Lys Lys Lys Gly Thr Tyr Leu Thr Asp Glu Thr His 
    370                 375                 380                 


Arg Glu Val Lys Phe Thr Ser Leu 
385                 390         


<210>  44
<211>  120
<212>  DNA
<213>  Unknown

<220>
<223>  linker

<400>  44
cgaaggaaac gaggaagcgg agaagccaga cacaaacaga aaattgtggc accggtgaaa       60

cagactttga attttgacct tctcaagttg gcgggagacg tcgagtccaa ccctgggccc      120


<210>  45
<211>  4548
<212>  DNA
<213>  Unknown

<220>
<223>  polynucleotide

<400>  45
cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt tggtcgcccg       60

gcctcagtga gcgagcgagc gcgcagagag ggagtggcca actccatcac taggggttcc      120

tggcgcgccg gagttccgcg ttacataact tacggtaaat ggcccgcctg gctgaccgcc      180

caacgacccc cgcccattga cgtcaataat gacgtatgtt cccatagtaa cgccaatagg      240

gactttccat tgacgtcaat gggtggagta tttacggtaa actgcccact tggcagtaca      300

tcaagtgtat catatgccaa gtacgccccc tattgacgtc aatgacggta aatggcccgc      360

ctggcattat gcccagtaca tgaccttatg ggactttcct acttggcagt acatctacgt      420

attagtcatc gctattacca tggtgatgcg gttttggcag tacatcaatg ggcgtggata      480

gcggtttgac tcacggggat ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt      540

ttggcaccaa aatcaacggg actttccaaa atgtcgtaac aactccgccc cattgacgca      600

aatgggcggt aggcgtgtac ggtgggaggt ctatataagc agagctcgtt tagtgaaccg      660

tcagatcgcc tggagacgcc atccacgctg ttttgacctc catagaagac accgactagt      720

gccaccatga aactgctgca tgtcttcctc ctcttcctgt gcttccacct ccgtttctgt      780

aaagtcacct acactagcca ggaggatctg gtggagaaga aatgcctggc caagaagtat      840

acccacctga gctgcgacaa agtgttctgc cagccctggc aacgctgcat tgaaggtact      900

tgtgtgtgca agctgcccta ccagtgcccc aagaacggca cggccgtgtg tgccaccaac      960

aggaggagct tccccaccta ctgccagcag aagagcctgg aatgcctcca ccctggcacc     1020

aagtttctga acaacgggac ctgcacagcc gaggggaaat tcagcgtctc cctcaagcac     1080

ggcaatacag actccgaggg cattgtggaa gtgaagctgg tggaccagga caagaccatg     1140

ttcatctgca aaagcagctg gtccatgcgg gaggccaatg tcgcctgcct ggacctgggc     1200

ttccagcagg gcgctgatac acagcgccgc tttaaactca gtgacctcag catcaacagc     1260

actgagtgtc tgcacgtgca ctgccggggc ctggagacca gcctggctga gtgcaccttc     1320

accaagcgca ggaccatggg ctaccaggat tttgcagatg tggtctgcta cacccagaag     1380

gcagacagcc ccatggatga cttcttccag tgtgtcaatg gcaagtacat ttcccagatg     1440

aaggcttgtg acgggatcaa tgattgcggg gatcagagcg atgagctctg ctgcaaggcc     1500

tgccaaggga agggctttca ctgtaagtct ggggtgtgca tcccttctca gtatcagtgc     1560

aacggagagg tggactgcat cactggggag gacgaggtgg gctgtgctgg cttcgcctct     1620

gtggcccagg aggagacaga gatcctcaca gctgacatgg atgcagagcg gcggcgcatc     1680

aagagtctgc tcccaaagct ctcctgcggc gttaagaatc gcatgcacat ccggaggaag     1740

cggatcgttg gaggcaaacg ggctcagctg ggggacttgc cgtggcaggt ggccatcaaa     1800

gatgcctccg gaatcacctg tggtggcatc tacatcggcg gctgctggat cctgaccgcc     1860

gcccactgcc ttcgggccag caagactcac cgctaccaga tctggaccac cgtggtggat     1920

tggattcacc ccgacctgaa gaggattgtc attgagtatg tcgaccgcat catcttccat     1980

gaaaactaca atgccgggac gtatcagaac gacatcgccc tcatcgagat gaagaaggat     2040

gggaacaaga aggactgtga gctgcctcgc tccatccccg cctgtgtacc atggtctccg     2100

tacctgttcc agccaaatga cacatgcatc gtgagcggct ggggccgcga gaaagacaac     2160

gagagggtct tctccctgca gtggggtgaa gtcaagctga tcagcaactg ctccaagttc     2220

tacggcaacc gcttctatga gaaggagatg gagtgcgccg gcacctatga cggcagcatt     2280

gacgcgtgca agggagacag tgggggcccc ctggtctgca tggacgccaa caatgtgacc     2340

tacgtgtggg gagttgtgtc ctggggcgag aactgtggca agcctgagtt cccgggcgtg     2400

tacacaaagg tggcaaacta ttttgactgg atctcctatc acgttggcag gcccttcatt     2460

tcacagtaca acgtacgaag gaaacgagga agcggagaag ccagacacaa acagaaaatt     2520

gtggcaccgg tgaaacagac tttgaatttt gaccttctca agttggcggg agacgtcgag     2580

tccaaccctg ggcccatgcg cctgctggcc aagatcatct gcctgatgct gtgggccatc     2640

tgcgtggcca gcgacaccgg ccgccccttc gtggagatgt acagcgagat ccccgagatc     2700

atccacatga ccgagggccg cgagctggtg atcccctgcc gcgtgaccag ccccaacatc     2760

accgtgaccc tgaagaagtt ccccctggac accctgatcc ccgacggcaa gcgcatcatc     2820

tgggacagcc gcaagggctt catcatcagc aacgccacct acaaggagat cggcctgctg     2880

acctgcgagg ccaccgtgaa cggccacctg tacaagacca actacctgac ccaccgccag     2940

accaacacca tcatcgacgt ggtgctgagc cccagccacg gcatcgagct gagcgtgggc     3000

gagaagctgg tgctgaactg caccgcccgc accgagctga acgtgggcat cgacttcaac     3060

tgggagtacc ccagcagcaa gcaccagcac aagaagctgg tgaaccgcga cctgaagacc     3120

cagagcggca gcgagatgaa gaagttcctg agcaccctga ccatcgacgg cgtgacccgc     3180

agcgaccagg gcctgtacac ctgcgccgcc agcagcggcc tgatgaccaa gaagaacagc     3240

accttcgtgc gcgtgcacga gaaggacaag acccacacct gccccccctg ccccgccccc     3300

gagctgctgg gcggccccag cgtgttcctg ttccccccca agcccaagga caccctgatg     3360

atcagccgca cccccgaggt gacctgcgtg gtggtggacg tgagccacga ggaccccgag     3420

gtgaagttca actggtacgt ggacggcgtg gaggtgcaca acgccaagac caagccccgc     3480

gaggagcagt acaacagcac ctaccgcgtg gtgagcgtgc tgaccgtgct gcaccaggac     3540

tggctgaacg gcaaggagta caagtgcaag gtgagcaaca aggccctgcc cgcccccatc     3600

gagaagacca tcagcaaggc caagggccag ccccgcgagc cccaggtgta caccctgccc     3660

cccagccgcg acgagctgac caagaaccag gtgagcctga cctgcctggt gaagggcttc     3720

taccccagcg acatcgccgt ggagtgggag agcaacggcc agcccgagaa caactacaag     3780

accacccccc ccgtgctgga cagcgacggc agcttcttcc tgtacagcaa gctgaccgtg     3840

gacaagagcc gctggcagca gggcaacgtg ttcagctgca gcgtgatgca cgaggccctg     3900

cacaaccact acacccagaa gagcctgagc ctgagccccg gctaactcga gaatcaacct     3960

ctggattaca aaatttgtga aagattgact ggtattctta actatgttgc tccttttacg     4020

ctatgtggat acgctgcttt aatgcctttg tatcatgcta ttgcttcccg tatggctttc     4080

attttctcct ccttgtataa atcctggtta gttcttgcca cggcggaact catcgccgcc     4140

tgccttgccc gctgctggac aggggctcgg ctgttgggca ctgacaattc cgtggtgtgc     4200

cttctagttg ccagccatct gttgtttgcc cctcccccgt gccttccttg accctggaag     4260

gtgccactcc cactgtcctt tcctaataaa atgaggaaat tgcatcgcat tgtctgagta     4320

ggtgtcattc tattctgggg ggtggggtgg ggcaggacag caagggggag gattgggaag     4380

acaatagcag gcatgctggg gatgcggtgg gctctatggg cggccgcagg aacccctagt     4440

gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa     4500

ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg agcgagcg                  4548


<210>  46
<211>  4548
<212>  DNA
<213>  Unknown

<220>
<223>  polynucleotide

<400>  46
cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt tggtcgcccg       60

gcctcagtga gcgagcgagc gcgcagagag ggagtggcca actccatcac taggggttcc      120

tggcgcgccg gagttccgcg ttacataact tacggtaaat ggcccgcctg gctgaccgcc      180

caacgacccc cgcccattga cgtcaataat gacgtatgtt cccatagtaa cgccaatagg      240

gactttccat tgacgtcaat gggtggagta tttacggtaa actgcccact tggcagtaca      300

tcaagtgtat catatgccaa gtacgccccc tattgacgtc aatgacggta aatggcccgc      360

ctggcattat gcccagtaca tgaccttatg ggactttcct acttggcagt acatctacgt      420

attagtcatc gctattacca tggtgatgcg gttttggcag tacatcaatg ggcgtggata      480

gcggtttgac tcacggggat ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt      540

ttggcaccaa aatcaacggg actttccaaa atgtcgtaac aactccgccc cattgacgca      600

aatgggcggt aggcgtgtac ggtgggaggt ctatataagc agagctcgtt tagtgaaccg      660

tcagatcgcc tggagacgcc atccacgctg ttttgacctc catagaagac accgactagt      720

gccaccatgc gcctgctggc caagatcatc tgcctgatgc tgtgggccat ctgcgtggcc      780

agcgacaccg gccgcccctt cgtggagatg tacagcgaga tccccgagat catccacatg      840

accgagggcc gcgagctggt gatcccctgc cgcgtgacca gccccaacat caccgtgacc      900

ctgaagaagt tccccctgga caccctgatc cccgacggca agcgcatcat ctgggacagc      960

cgcaagggct tcatcatcag caacgccacc tacaaggaga tcggcctgct gacctgcgag     1020

gccaccgtga acggccacct gtacaagacc aactacctga cccaccgcca gaccaacacc     1080

atcatcgacg tggtgctgag ccccagccac ggcatcgagc tgagcgtggg cgagaagctg     1140

gtgctgaact gcaccgcccg caccgagctg aacgtgggca tcgacttcaa ctgggagtac     1200

cccagcagca agcaccagca caagaagctg gtgaaccgcg acctgaagac ccagagcggc     1260

agcgagatga agaagttcct gagcaccctg accatcgacg gcgtgacccg cagcgaccag     1320

ggcctgtaca cctgcgccgc cagcagcggc ctgatgacca agaagaacag caccttcgtg     1380

cgcgtgcacg agaaggacaa gacccacacc tgccccccct gccccgcccc cgagctgctg     1440

ggcggcccca gcgtgttcct gttccccccc aagcccaagg acaccctgat gatcagccgc     1500

acccccgagg tgacctgcgt ggtggtggac gtgagccacg aggaccccga ggtgaagttc     1560

aactggtacg tggacggcgt ggaggtgcac aacgccaaga ccaagccccg cgaggagcag     1620

tacaacagca cctaccgcgt ggtgagcgtg ctgaccgtgc tgcaccagga ctggctgaac     1680

ggcaaggagt acaagtgcaa ggtgagcaac aaggccctgc ccgcccccat cgagaagacc     1740

atcagcaagg ccaagggcca gccccgcgag ccccaggtgt acaccctgcc ccccagccgc     1800

gacgagctga ccaagaacca ggtgagcctg acctgcctgg tgaagggctt ctaccccagc     1860

gacatcgccg tggagtggga gagcaacggc cagcccgaga acaactacaa gaccaccccc     1920

cccgtgctgg acagcgacgg cagcttcttc ctgtacagca agctgaccgt ggacaagagc     1980

cgctggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     2040

tacacccaga agagcctgag cctgagcccc ggctaacgaa ggaaacgagg aagcggagaa     2100

gccagacaca aacagaaaat tgtggcaccg gtgaaacaga ctttgaattt tgaccttctc     2160

aagttggcgg gagacgtcga gtccaaccct gggcccatga aactgctgca tgtcttcctc     2220

ctcttcctgt gcttccacct ccgtttctgt aaagtcacct acactagcca ggaggatctg     2280

gtggagaaga aatgcctggc caagaagtat acccacctga gctgcgacaa agtgttctgc     2340

cagccctggc aacgctgcat tgaaggtact tgtgtgtgca agctgcccta ccagtgcccc     2400

aagaacggca cggccgtgtg tgccaccaac aggaggagct tccccaccta ctgccagcag     2460

aagagcctgg aatgcctcca ccctggcacc aagtttctga acaacgggac ctgcacagcc     2520

gaggggaaat tcagcgtctc cctcaagcac ggcaatacag actccgaggg cattgtggaa     2580

gtgaagctgg tggaccagga caagaccatg ttcatctgca aaagcagctg gtccatgcgg     2640

gaggccaatg tcgcctgcct ggacctgggc ttccagcagg gcgctgatac acagcgccgc     2700

tttaaactca gtgacctcag catcaacagc actgagtgtc tgcacgtgca ctgccggggc     2760

ctggagacca gcctggctga gtgcaccttc accaagcgca ggaccatggg ctaccaggat     2820

tttgcagatg tggtctgcta cacccagaag gcagacagcc ccatggatga cttcttccag     2880

tgtgtcaatg gcaagtacat ttcccagatg aaggcttgtg acgggatcaa tgattgcggg     2940

gatcagagcg atgagctctg ctgcaaggcc tgccaaggga agggctttca ctgtaagtct     3000

ggggtgtgca tcccttctca gtatcagtgc aacggagagg tggactgcat cactggggag     3060

gacgaggtgg gctgtgctgg cttcgcctct gtggcccagg aggagacaga gatcctcaca     3120

gctgacatgg atgcagagcg gcggcgcatc aagagtctgc tcccaaagct ctcctgcggc     3180

gttaagaatc gcatgcacat ccggaggaag cggatcgttg gaggcaaacg ggctcagctg     3240

ggggacttgc cgtggcaggt ggccatcaaa gatgcctccg gaatcacctg tggtggcatc     3300

tacatcggcg gctgctggat cctgaccgcc gcccactgcc ttcgggccag caagactcac     3360

cgctaccaga tctggaccac cgtggtggat tggattcacc ccgacctgaa gaggattgtc     3420

attgagtatg tcgaccgcat catcttccat gaaaactaca atgccgggac gtatcagaac     3480

gacatcgccc tcatcgagat gaagaaggat gggaacaaga aggactgtga gctgcctcgc     3540

tccatccccg cctgtgtacc atggtctccg tacctgttcc agccaaatga cacatgcatc     3600

gtgagcggct ggggccgcga gaaagacaac gagagggtct tctccctgca gtggggtgaa     3660

gtcaagctga tcagcaactg ctccaagttc tacggcaacc gcttctatga gaaggagatg     3720

gagtgcgccg gcacctatga cggcagcatt gacgcgtgca agggagacag tgggggcccc     3780

ctggtctgca tggacgccaa caatgtgacc tacgtgtggg gagttgtgtc ctggggcgag     3840

aactgtggca agcctgagtt cccgggcgtg tacacaaagg tggcaaacta ttttgactgg     3900

atctcctatc acgttggcag gcccttcatt tcacagtaca acgtactcga gaatcaacct     3960

ctggattaca aaatttgtga aagattgact ggtattctta actatgttgc tccttttacg     4020

ctatgtggat acgctgcttt aatgcctttg tatcatgcta ttgcttcccg tatggctttc     4080

attttctcct ccttgtataa atcctggtta gttcttgcca cggcggaact catcgccgcc     4140

tgccttgccc gctgctggac aggggctcgg ctgttgggca ctgacaattc cgtggtgtgc     4200

cttctagttg ccagccatct gttgtttgcc cctcccccgt gccttccttg accctggaag     4260

gtgccactcc cactgtcctt tcctaataaa atgaggaaat tgcatcgcat tgtctgagta     4320

ggtgtcattc tattctgggg ggtggggtgg ggcaggacag caagggggag gattgggaag     4380

acaatagcag gcatgctggg gatgcggtgg gctctatggg cggccgcagg aacccctagt     4440

gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa     4500

ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg agcgagcg                  4548


<210>  47
<211>  4303
<212>  DNA
<213>  Unknown

<220>
<223>  polynucleotide

<400>  47
cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt tggtcgcccg       60

gcctcagtga gcgagcgagc gcgcagagag ggagtggcca actccatcac taggggttcc      120

tggcgcgccg gagttccgcg ttacataact tacggtaaat ggcccgcctg gctgaccgcc      180

caacgacccc cgcccattga cgtcaataat gacgtatgtt cccatagtaa cgccaatagg      240

gactttccat tgacgtcaat gggtggagta tttacggtaa actgcccact tggcagtaca      300

tcaagtgtat catatgccaa gtacgccccc tattgacgtc aatgacggta aatggcccgc      360

ctggcattat gcccagtaca tgaccttatg ggactttcct acttggcagt acatctacgt      420

attagtcatc gctattacca tggtgatgcg gttttggcag tacatcaatg ggcgtggata      480

gcggtttgac tcacggggat ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt      540

ttggcaccaa aatcaacggg actttccaaa atgtcgtaac aactccgccc cattgacgca      600

aatgggcggt aggcgtgtac ggtgggaggt ctatataagc agagctcgtt tagtgaaccg      660

tcagatcgcc tggagacgcc atccacgctg ttttgacctc catagaagac accgactagt      720

gccaccatga aactgctgca tgtcttcctc ctcttcctgt gcttccacct ccgtttctgt      780

aaagtcacct acactagcca ggaggatctg gtggagaaga aatgcctggc caagaagtat      840

acccacctga gctgcgacaa agtgttctgc cagccctggc aacgctgcat tgaaggtact      900

tgtgtgtgca agctgcccta ccagtgcccc aagaacggca cggccgtgtg tgccaccaac      960

aggaggagct tccccaccta ctgccagcag aagagcctgg aatgcctcca ccctggcacc     1020

aagtttctga acaacgggac ctgcacagcc gaggggaaat tcagcgtctc cctcaagcac     1080

ggcaatacag actccgaggg cattgtggaa gtgaagctgg tggaccagga caagaccatg     1140

ttcatctgca aaagcagctg gtccatgcgg gaggccaatg tcgcctgcct ggacctgggc     1200

ttccagcagg gcgctgatac acagcgccgc tttaaactca gtgacctcag catcaacagc     1260

actgagtgtc tgcacgtgca ctgccggggc ctggagacca gcctggctga gtgcaccttc     1320

accaagcgca ggaccatggg ctaccaggat tttgcagatg tggtctgcta cacccagaag     1380

gcagacagcc ccatggatga cttcttccag tgtgtcaatg gcaagtacat ttcccagatg     1440

aaggcttgtg acgggatcaa tgattgcggg gatcagagcg atgagctctg ctgcaaggcc     1500

tgccaaggga agggctttca ctgtaagtct ggggtgtgca tcccttctca gtatcagtgc     1560

aacggagagg tggactgcat cactggggag gacgaggtgg gctgtgctgg cttcgcctct     1620

gtggcccagg aggagacaga gatcctcaca gctgacatgg atgcagagcg gcggcgcatc     1680

aagagtctgc tcccaaagct ctcctgcggc gttaagaatc gcatgcacat ccggaggaag     1740

cggatcgttg gaggcaaacg ggctcagctg ggggacttgc cgtggcaggt ggccatcaaa     1800

gatgcctccg gaatcacctg tggtggcatc tacatcggcg gctgctggat cctgaccgcc     1860

gcccactgcc ttcgggccag caagactcac cgctaccaga tctggaccac cgtggtggat     1920

tggattcacc ccgacctgaa gaggattgtc attgagtatg tcgaccgcat catcttccat     1980

gaaaactaca atgccgggac gtatcagaac gacatcgccc tcatcgagat gaagaaggat     2040

gggaacaaga aggactgtga gctgcctcgc tccatccccg cctgtgtacc atggtctccg     2100

tacctgttcc agccaaatga cacatgcatc gtgagcggct ggggccgcga gaaagacaac     2160

gagagggtct tctccctgca gtggggtgaa gtcaagctga tcagcaactg ctccaagttc     2220

tacggcaacc gcttctatga gaaggagatg gagtgcgccg gcacctatga cggcagcatt     2280

gacgcgtgca agggagacag tgggggcccc ctggtctgca tggacgccaa caatgtgacc     2340

tacgtgtggg gagttgtgtc ctggggcgag aactgtggca agcctgagtt cccgggcgtg     2400

tacacaaagg tggcaaacta ttttgactgg atctcctatc acgttggcag gcccttcatt     2460

tcacagtaca acgtacgaag gaaacgagga agcggagaag ccagacacaa acagaaaatt     2520

gtggcaccgg tgaaacagac tttgaatttt gaccttctca agttggcggg agacgtcgag     2580

tccaaccctg ggcccatgcg cctgctggcc aagatcatct gcctgatgct gtgggccatc     2640

tgcgtggcca gcgacaccgg ccgccccttc gtggagatgt acagcgagat ccccgagatc     2700

atccacatga ccgagggccg cgagctggtg atcccctgcc gcgtgaccag ccccaacatc     2760

accgtgaccc tgaagaagtt ccccctggac accctgatcc ccgacggcaa gcgcatcatc     2820

tgggacagcc gcaagggctt catcatcagc aacgccacct acaaggagat cggcctgctg     2880

acctgcgagg ccaccgtgaa cggccacctg tacaagacca actacctgac ccaccgccag     2940

accaacacca tcatcgacgt ggtgctgagc cccagccacg gcatcgagct gagcgtgggc     3000

gagaagctgg tgctgaactg caccgcccgc accgagctga acgtgggcat cgacttcaac     3060

tgggagtacc ccagcagcaa gcaccagcac aagaagctgg tgaaccgcga cctgaagacc     3120

cagagcggca gcgagatgaa gaagttcctg agcaccctga ccatcgacgg cgtgacccgc     3180

agcgaccagg gcctgtacac ctgcgccgcc agcagcggcc tgatgaccaa gaagaacagc     3240

accttcgtgc gcgtgcacga gaaggacaag acccacacct gccccccctg ccccgccccc     3300

gagctgctgg gcggccccag cgtgttcctg ttccccccca agcccaagga caccctgatg     3360

atcagccgca cccccgaggt gacctgcgtg gtggtggacg tgagccacga ggaccccgag     3420

gtgaagttca actggtacgt ggacggcgtg gaggtgcaca acgccaagac caagccccgc     3480

gaggagcagt acaacagcac ctaccgcgtg gtgagcgtgc tgaccgtgct gcaccaggac     3540

tggctgaacg gcaaggagta caagtgcaag gtgagcaaca aggccctgcc cgcccccatc     3600

gagaagacca tcagcaaggc caagggccag ccccgcgagc cccaggtgta caccctgccc     3660

cccagccgcg acgagctgac caagaaccag gtgagcctga cctgcctggt gaagggcttc     3720

taccccagcg acatcgccgt ggagtgggag agcaacggcc agcccgagaa caactacaag     3780

accacccccc ccgtgctgga cagcgacggc agcttcttcc tgtacagcaa gctgaccgtg     3840

gacaagagcc gctggcagca gggcaacgtg ttcagctgca gcgtgatgca cgaggccctg     3900

cacaaccact acacccagaa gagcctgagc ctgagccccg gctaactcga ggtgccttct     3960

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     4020

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     4080

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     4140

agcaggcatg ctggggatgc ggtgggctct atgggcggcc gcaggaaccc ctagtgatgg     4200

agttggccac tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg     4260

cccgacgccc gggctttgcc cgggcggcct cagtgagcga gcg                       4303


<210>  48
<211>  4303
<212>  DNA
<213>  Unknown

<220>
<223>  polynucleotide

<400>  48
cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt tggtcgcccg       60

gcctcagtga gcgagcgagc gcgcagagag ggagtggcca actccatcac taggggttcc      120

tggcgcgccg gagttccgcg ttacataact tacggtaaat ggcccgcctg gctgaccgcc      180

caacgacccc cgcccattga cgtcaataat gacgtatgtt cccatagtaa cgccaatagg      240

gactttccat tgacgtcaat gggtggagta tttacggtaa actgcccact tggcagtaca      300

tcaagtgtat catatgccaa gtacgccccc tattgacgtc aatgacggta aatggcccgc      360

ctggcattat gcccagtaca tgaccttatg ggactttcct acttggcagt acatctacgt      420

attagtcatc gctattacca tggtgatgcg gttttggcag tacatcaatg ggcgtggata      480

gcggtttgac tcacggggat ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt      540

ttggcaccaa aatcaacggg actttccaaa atgtcgtaac aactccgccc cattgacgca      600

aatgggcggt aggcgtgtac ggtgggaggt ctatataagc agagctcgtt tagtgaaccg      660

tcagatcgcc tggagacgcc atccacgctg ttttgacctc catagaagac accgactagt      720

gccaccatgc gcctgctggc caagatcatc tgcctgatgc tgtgggccat ctgcgtggcc      780

agcgacaccg gccgcccctt cgtggagatg tacagcgaga tccccgagat catccacatg      840

accgagggcc gcgagctggt gatcccctgc cgcgtgacca gccccaacat caccgtgacc      900

ctgaagaagt tccccctgga caccctgatc cccgacggca agcgcatcat ctgggacagc      960

cgcaagggct tcatcatcag caacgccacc tacaaggaga tcggcctgct gacctgcgag     1020

gccaccgtga acggccacct gtacaagacc aactacctga cccaccgcca gaccaacacc     1080

atcatcgacg tggtgctgag ccccagccac ggcatcgagc tgagcgtggg cgagaagctg     1140

gtgctgaact gcaccgcccg caccgagctg aacgtgggca tcgacttcaa ctgggagtac     1200

cccagcagca agcaccagca caagaagctg gtgaaccgcg acctgaagac ccagagcggc     1260

agcgagatga agaagttcct gagcaccctg accatcgacg gcgtgacccg cagcgaccag     1320

ggcctgtaca cctgcgccgc cagcagcggc ctgatgacca agaagaacag caccttcgtg     1380

cgcgtgcacg agaaggacaa gacccacacc tgccccccct gccccgcccc cgagctgctg     1440

ggcggcccca gcgtgttcct gttccccccc aagcccaagg acaccctgat gatcagccgc     1500

acccccgagg tgacctgcgt ggtggtggac gtgagccacg aggaccccga ggtgaagttc     1560

aactggtacg tggacggcgt ggaggtgcac aacgccaaga ccaagccccg cgaggagcag     1620

tacaacagca cctaccgcgt ggtgagcgtg ctgaccgtgc tgcaccagga ctggctgaac     1680

ggcaaggagt acaagtgcaa ggtgagcaac aaggccctgc ccgcccccat cgagaagacc     1740

atcagcaagg ccaagggcca gccccgcgag ccccaggtgt acaccctgcc ccccagccgc     1800

gacgagctga ccaagaacca ggtgagcctg acctgcctgg tgaagggctt ctaccccagc     1860

gacatcgccg tggagtggga gagcaacggc cagcccgaga acaactacaa gaccaccccc     1920

cccgtgctgg acagcgacgg cagcttcttc ctgtacagca agctgaccgt ggacaagagc     1980

cgctggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     2040

tacacccaga agagcctgag cctgagcccc ggctaacgaa ggaaacgagg aagcggagaa     2100

gccagacaca aacagaaaat tgtggcaccg gtgaaacaga ctttgaattt tgaccttctc     2160

aagttggcgg gagacgtcga gtccaaccct gggcccatga aactgctgca tgtcttcctc     2220

ctcttcctgt gcttccacct ccgtttctgt aaagtcacct acactagcca ggaggatctg     2280

gtggagaaga aatgcctggc caagaagtat acccacctga gctgcgacaa agtgttctgc     2340

cagccctggc aacgctgcat tgaaggtact tgtgtgtgca agctgcccta ccagtgcccc     2400

aagaacggca cggccgtgtg tgccaccaac aggaggagct tccccaccta ctgccagcag     2460

aagagcctgg aatgcctcca ccctggcacc aagtttctga acaacgggac ctgcacagcc     2520

gaggggaaat tcagcgtctc cctcaagcac ggcaatacag actccgaggg cattgtggaa     2580

gtgaagctgg tggaccagga caagaccatg ttcatctgca aaagcagctg gtccatgcgg     2640

gaggccaatg tcgcctgcct ggacctgggc ttccagcagg gcgctgatac acagcgccgc     2700

tttaaactca gtgacctcag catcaacagc actgagtgtc tgcacgtgca ctgccggggc     2760

ctggagacca gcctggctga gtgcaccttc accaagcgca ggaccatggg ctaccaggat     2820

tttgcagatg tggtctgcta cacccagaag gcagacagcc ccatggatga cttcttccag     2880

tgtgtcaatg gcaagtacat ttcccagatg aaggcttgtg acgggatcaa tgattgcggg     2940

gatcagagcg atgagctctg ctgcaaggcc tgccaaggga agggctttca ctgtaagtct     3000

ggggtgtgca tcccttctca gtatcagtgc aacggagagg tggactgcat cactggggag     3060

gacgaggtgg gctgtgctgg cttcgcctct gtggcccagg aggagacaga gatcctcaca     3120

gctgacatgg atgcagagcg gcggcgcatc aagagtctgc tcccaaagct ctcctgcggc     3180

gttaagaatc gcatgcacat ccggaggaag cggatcgttg gaggcaaacg ggctcagctg     3240

ggggacttgc cgtggcaggt ggccatcaaa gatgcctccg gaatcacctg tggtggcatc     3300

tacatcggcg gctgctggat cctgaccgcc gcccactgcc ttcgggccag caagactcac     3360

cgctaccaga tctggaccac cgtggtggat tggattcacc ccgacctgaa gaggattgtc     3420

attgagtatg tcgaccgcat catcttccat gaaaactaca atgccgggac gtatcagaac     3480

gacatcgccc tcatcgagat gaagaaggat gggaacaaga aggactgtga gctgcctcgc     3540

tccatccccg cctgtgtacc atggtctccg tacctgttcc agccaaatga cacatgcatc     3600

gtgagcggct ggggccgcga gaaagacaac gagagggtct tctccctgca gtggggtgaa     3660

gtcaagctga tcagcaactg ctccaagttc tacggcaacc gcttctatga gaaggagatg     3720

gagtgcgccg gcacctatga cggcagcatt gacgcgtgca agggagacag tgggggcccc     3780

ctggtctgca tggacgccaa caatgtgacc tacgtgtggg gagttgtgtc ctggggcgag     3840

aactgtggca agcctgagtt cccgggcgtg tacacaaagg tggcaaacta ttttgactgg     3900

atctcctatc acgttggcag gcccttcatt tcacagtaca acgtactcga ggtgccttct     3960

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     4020

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     4080

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     4140

agcaggcatg ctggggatgc ggtgggctct atgggcggcc gcaggaaccc ctagtgatgg     4200

agttggccac tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg     4260

cccgacgccc gggctttgcc cgggcggcct cagtgagcga gcg                       4303


<210>  49
<211>  4519
<212>  DNA
<213>  Unknown

<220>
<223>  polynucleotide

<400>  49
cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt tggtcgcccg       60

gcctcagtga gcgagcgagc gcgcagagag ggagtggcca actccatcac taggggttcc      120

tggcgcgccg gagttccgcg ttacataact tacggtaaat ggcccgcctg gctgaccgcc      180

caacgacccc cgcccattga cgtcaataat gacgtatgtt cccatagtaa cgccaatagg      240

gactttccat tgacgtcaat gggtggagta tttacggtaa actgcccact tggcagtaca      300

tcaagtgtat catatgccaa gtacgccccc tattgacgtc aatgacggta aatggcccgc      360

ctggcattat gcccagtaca tgaccttatg ggactttcct acttggcagt acatctacgt      420

attagtcatc gctattacca tggtgatgcg gttttggcag tacatcaatg ggcgtggata      480

gcggtttgac tcacggggat ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt      540

ttggcaccaa aatcaacggg actttccaaa atgtcgtaac aactccgccc cattgacgca      600

aatgggcggt aggcgtgtac ggtgggaggt ctatataagc agagctcgtt tagtgaaccg      660

tcagatcgcc tggagacgcc atccacgctg ttttgacctc catagaagac accgactagt      720

gccaccatgc gcctcctggc caagatcatc tgcctcatgc tgtgggccat ctgcgtggct      780

gaggactgca atgagctgcc gcccaggagg aacacagaga tcctgacagg gagctggtct      840

gaccagacct accctgaggg cacccaggcg atctacaagt gccggccggg ctacaggagc      900

ctggggaaca tcatcatggt gtgtagaaag ggcgaatggg tggccctcaa ccccctgagg      960

aagtgccaga agcggccctg tggccacccc ggggacacac ccttcgggac cttcaccctg     1020

accggcggca atgtgtttga gtacggcgtg aaggctgtct acacatgcaa cgaggggtac     1080

cagctgctgg gcgagattaa ctaccgggag tgtgacaccg atgggtggac caacgacatt     1140

cccatctgtg aggtggtcaa gtgtctcccc gtgacagccc cagaaaatgg caaaatcgtg     1200

agcagcgcca tggagcctga ccgcgaatat cactttgggc aggccgtgag gtttgtgtgc     1260

aactcgggct acaaaattga aggtgatgag gagatgcact gcagcgatga tggcttctgg     1320

tccaaggaga agcccaaatg tgtggagatc tcctgcaagt ctcccgacgt gatcaacggc     1380

agcccaatca gccagaagat tatttacaaa gagaacgagc gcttccagta caagtgtaac     1440

atgggctatg agtattcaga gaggggagat gccgtctgca ctgagagcgg ctggagacca     1500

ctgcctagct gcgaggaaaa gagttgtgac aacccttaca tcccaaatgg cgactactcc     1560

cctctgcgga tcaaacaccg gaccggggat gaaatcacct atcagtgccg caatggattc     1620

tacccggcca cccgcggcaa caccgccaaa tgcaccagca caggctggat ccccgccccc     1680

cgctgtacgc tgaagccttg cgactatcca gacatcaagc acggaggcct gtaccacgaa     1740

aacatgcggc ggccttattt ccctgtggca gtggggaagt actacagcta ctactgcgac     1800

gagcacttcg agaccccctc tggctcctac tgggaccaca tccactgcac acaggacggc     1860

tggtctccag ctgtgccctg cctgaggaaa tgctacttcc cctacctgga gaacggatac     1920

aaccagaact atggccgcaa gttcgtgcag ggcaagagca tcgatgtggc ctgccaccct     1980

ggctacgccc tgcccaaggc ccagacaact gtgacctgca tggagaatgg ttggagcccc     2040

accccgcgct gcatccgggt gtccttcacg ctccgaagga aacgaggaag cggagaagcc     2100

agacacaaac agaaaattgt ggcaccggtg aaacagactt tgaattttga ccttctcaag     2160

ttggcgggag acgtcgagtc caaccctggg cccatgcgcc tgctggccaa gatcatctgc     2220

ctgatgctgt gggccatctg cgtggccagc gacaccggcc gccccttcgt ggagatgtac     2280

agcgagatcc ccgagatcat ccacatgacc gagggccgcg agctggtgat cccctgccgc     2340

gtgaccagcc ccaacatcac cgtgaccctg aagaagttcc ccctggacac cctgatcccc     2400

gacggcaagc gcatcatctg ggacagccgc aagggcttca tcatcagcaa cgccacctac     2460

aaggagatcg gcctgctgac ctgcgaggcc accgtgaacg gccacctgta caagaccaac     2520

tacctgaccc accgccagac caacaccatc atcgacgtgg tgctgagccc cagccacggc     2580

atcgagctga gcgtgggcga gaagctggtg ctgaactgca ccgcccgcac cgagctgaac     2640

gtgggcatcg acttcaactg ggagtacccc agcagcaagc accagcacaa gaagctggtg     2700

aaccgcgacc tgaagaccca gagcggcagc gagatgaaga agttcctgag caccctgacc     2760

atcgacggcg tgacccgcag cgaccagggc ctgtacacct gcgccgccag cagcggcctg     2820

atgaccaaga agaacagcac cttcgtgcgc gtgcacgaga aggacaagac ccacacctgc     2880

cccccctgcc ccgcccccga gctgctgggc ggccccagcg tgttcctgtt cccccccaag     2940

cccaaggaca ccctgatgat cagccgcacc cccgaggtga cctgcgtggt ggtggacgtg     3000

agccacgagg accccgaggt gaagttcaac tggtacgtgg acggcgtgga ggtgcacaac     3060

gccaagacca agccccgcga ggagcagtac aacagcacct accgcgtggt gagcgtgctg     3120

accgtgctgc accaggactg gctgaacggc aaggagtaca agtgcaaggt gagcaacaag     3180

gccctgcccg cccccatcga gaagaccatc agcaaggcca agggccagcc ccgcgagccc     3240

caggtgtaca ccctgccccc cagccgcgac gagctgacca agaaccaggt gagcctgacc     3300

tgcctggtga agggcttcta ccccagcgac atcgccgtgg agtgggagag caacggccag     3360

cccgagaaca actacaagac cacccccccc gtgctggaca gcgacggcag cttcttcctg     3420

tacagcaagc tgaccgtgga caagagccgc tggcagcagg gcaacgtgtt cagctgcagc     3480

gtgatgcacg aggccctgca caaccactac acccagaaga gcctgagcct gagccccggc     3540

taactcgaga atcaacctct ggattacaaa atttgtgaaa gattgactgg tattcttaac     3600

tatgttgctc cttttacgct atgtggatac gctgctttaa tgcctttgta tcatgctatt     3660

gcttcccgta tggctttcat tttctcctcc ttgtataaat cctggttgct gtctctttat     3720

gaggagttgt ggcccgttgt caggcaacgt ggcgtggtgt gcactgtgtt tgctgacgca     3780

acccccactg gttggggcat tgccaccacc tgtcagctcc tttccgggac tttcgctttc     3840

cccctcccta ttgccacggc ggaactcatc gccgcctgcc ttgcccgctg ctggacaggg     3900

gctcggctgt tgggcactga caattccgtg gtgttgtcgg ggaaatcatc gtcctttcct     3960

tggctgctcg cctgtgttgc cacctggatt ctgcgcggga cgtccttctg ctacgtccct     4020

tcggccctca atccagcgga ccttccttcc cgcggcctgc tgccggctct gcggcctctt     4080

ccgcgtcttc gccttcgccc tcagacgagt cggatctccc tttgggccgc ctccccgcat     4140

cgataccgtc gactcgctga tcagcctgtg ccttctagtt gccagccatc tgttgtttgc     4200

ccctcccccg tgccttcctt gaccctggaa ggtgccactc ccactgtcct ttcctaataa     4260

aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg gggtggggtg     4320

gggcaggaca gcaaggggga ggattgggaa gacaatagca ggcatgctgg ggatgcggtg     4380

ggctctatgg gcggccgcag gaacccctag tgatggagtt ggccactccc tctctgcgcg     4440

ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg     4500

cggcctcagt gagcgagcg                                                  4519


<210>  50
<211>  4519
<212>  DNA
<213>  Unknown

<220>
<223>  polynucleotide

<400>  50
cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt tggtcgcccg       60

gcctcagtga gcgagcgagc gcgcagagag ggagtggcca actccatcac taggggttcc      120

tggcgcgccg gagttccgcg ttacataact tacggtaaat ggcccgcctg gctgaccgcc      180

caacgacccc cgcccattga cgtcaataat gacgtatgtt cccatagtaa cgccaatagg      240

gactttccat tgacgtcaat gggtggagta tttacggtaa actgcccact tggcagtaca      300

tcaagtgtat catatgccaa gtacgccccc tattgacgtc aatgacggta aatggcccgc      360

ctggcattat gcccagtaca tgaccttatg ggactttcct acttggcagt acatctacgt      420

attagtcatc gctattacca tggtgatgcg gttttggcag tacatcaatg ggcgtggata      480

gcggtttgac tcacggggat ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt      540

ttggcaccaa aatcaacggg actttccaaa atgtcgtaac aactccgccc cattgacgca      600

aatgggcggt aggcgtgtac ggtgggaggt ctatataagc agagctcgtt tagtgaaccg      660

tcagatcgcc tggagacgcc atccacgctg ttttgacctc catagaagac accgactagt      720

gccaccatgc gcctgctggc caagatcatc tgcctgatgc tgtgggccat ctgcgtggcc      780

agcgacaccg gccgcccctt cgtggagatg tacagcgaga tccccgagat catccacatg      840

accgagggcc gcgagctggt gatcccctgc cgcgtgacca gccccaacat caccgtgacc      900

ctgaagaagt tccccctgga caccctgatc cccgacggca agcgcatcat ctgggacagc      960

cgcaagggct tcatcatcag caacgccacc tacaaggaga tcggcctgct gacctgcgag     1020

gccaccgtga acggccacct gtacaagacc aactacctga cccaccgcca gaccaacacc     1080

atcatcgacg tggtgctgag ccccagccac ggcatcgagc tgagcgtggg cgagaagctg     1140

gtgctgaact gcaccgcccg caccgagctg aacgtgggca tcgacttcaa ctgggagtac     1200

cccagcagca agcaccagca caagaagctg gtgaaccgcg acctgaagac ccagagcggc     1260

agcgagatga agaagttcct gagcaccctg accatcgacg gcgtgacccg cagcgaccag     1320

ggcctgtaca cctgcgccgc cagcagcggc ctgatgacca agaagaacag caccttcgtg     1380

cgcgtgcacg agaaggacaa gacccacacc tgccccccct gccccgcccc cgagctgctg     1440

ggcggcccca gcgtgttcct gttccccccc aagcccaagg acaccctgat gatcagccgc     1500

acccccgagg tgacctgcgt ggtggtggac gtgagccacg aggaccccga ggtgaagttc     1560

aactggtacg tggacggcgt ggaggtgcac aacgccaaga ccaagccccg cgaggagcag     1620

tacaacagca cctaccgcgt ggtgagcgtg ctgaccgtgc tgcaccagga ctggctgaac     1680

ggcaaggagt acaagtgcaa ggtgagcaac aaggccctgc ccgcccccat cgagaagacc     1740

atcagcaagg ccaagggcca gccccgcgag ccccaggtgt acaccctgcc ccccagccgc     1800

gacgagctga ccaagaacca ggtgagcctg acctgcctgg tgaagggctt ctaccccagc     1860

gacatcgccg tggagtggga gagcaacggc cagcccgaga acaactacaa gaccaccccc     1920

cccgtgctgg acagcgacgg cagcttcttc ctgtacagca agctgaccgt ggacaagagc     1980

cgctggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     2040

tacacccaga agagcctgag cctgagcccc ggctaacgaa ggaaacgagg aagcggagaa     2100

gccagacaca aacagaaaat tgtggcaccg gtgaaacaga ctttgaattt tgaccttctc     2160

aagttggcgg gagacgtcga gtccaaccct gggcccatgc gcctcctggc caagatcatc     2220

tgcctcatgc tgtgggccat ctgcgtggct gaggactgca atgagctgcc gcccaggagg     2280

aacacagaga tcctgacagg gagctggtct gaccagacct accctgaggg cacccaggcg     2340

atctacaagt gccggccggg ctacaggagc ctggggaaca tcatcatggt gtgtagaaag     2400

ggcgaatggg tggccctcaa ccccctgagg aagtgccaga agcggccctg tggccacccc     2460

ggggacacac ccttcgggac cttcaccctg accggcggca atgtgtttga gtacggcgtg     2520

aaggctgtct acacatgcaa cgaggggtac cagctgctgg gcgagattaa ctaccgggag     2580

tgtgacaccg atgggtggac caacgacatt cccatctgtg aggtggtcaa gtgtctcccc     2640

gtgacagccc cagaaaatgg caaaatcgtg agcagcgcca tggagcctga ccgcgaatat     2700

cactttgggc aggccgtgag gtttgtgtgc aactcgggct acaaaattga aggtgatgag     2760

gagatgcact gcagcgatga tggcttctgg tccaaggaga agcccaaatg tgtggagatc     2820

tcctgcaagt ctcccgacgt gatcaacggc agcccaatca gccagaagat tatttacaaa     2880

gagaacgagc gcttccagta caagtgtaac atgggctatg agtattcaga gaggggagat     2940

gccgtctgca ctgagagcgg ctggagacca ctgcctagct gcgaggaaaa gagttgtgac     3000

aacccttaca tcccaaatgg cgactactcc cctctgcgga tcaaacaccg gaccggggat     3060

gaaatcacct atcagtgccg caatggattc tacccggcca cccgcggcaa caccgccaaa     3120

tgcaccagca caggctggat ccccgccccc cgctgtacgc tgaagccttg cgactatcca     3180

gacatcaagc acggaggcct gtaccacgaa aacatgcggc ggccttattt ccctgtggca     3240

gtggggaagt actacagcta ctactgcgac gagcacttcg agaccccctc tggctcctac     3300

tgggaccaca tccactgcac acaggacggc tggtctccag ctgtgccctg cctgaggaaa     3360

tgctacttcc cctacctgga gaacggatac aaccagaact atggccgcaa gttcgtgcag     3420

ggcaagagca tcgatgtggc ctgccaccct ggctacgccc tgcccaaggc ccagacaact     3480

gtgacctgca tggagaatgg ttggagcccc accccgcgct gcatccgggt gtccttcacg     3540

ctcctcgaga atcaacctct ggattacaaa atttgtgaaa gattgactgg tattcttaac     3600

tatgttgctc cttttacgct atgtggatac gctgctttaa tgcctttgta tcatgctatt     3660

gcttcccgta tggctttcat tttctcctcc ttgtataaat cctggttgct gtctctttat     3720

gaggagttgt ggcccgttgt caggcaacgt ggcgtggtgt gcactgtgtt tgctgacgca     3780

acccccactg gttggggcat tgccaccacc tgtcagctcc tttccgggac tttcgctttc     3840

cccctcccta ttgccacggc ggaactcatc gccgcctgcc ttgcccgctg ctggacaggg     3900

gctcggctgt tgggcactga caattccgtg gtgttgtcgg ggaaatcatc gtcctttcct     3960

tggctgctcg cctgtgttgc cacctggatt ctgcgcggga cgtccttctg ctacgtccct     4020

tcggccctca atccagcgga ccttccttcc cgcggcctgc tgccggctct gcggcctctt     4080

ccgcgtcttc gccttcgccc tcagacgagt cggatctccc tttgggccgc ctccccgcat     4140

cgataccgtc gactcgctga tcagcctgtg ccttctagtt gccagccatc tgttgtttgc     4200

ccctcccccg tgccttcctt gaccctggaa ggtgccactc ccactgtcct ttcctaataa     4260

aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg gggtggggtg     4320

gggcaggaca gcaaggggga ggattgggaa gacaatagca ggcatgctgg ggatgcggtg     4380

ggctctatgg gcggccgcag gaacccctag tgatggagtt ggccactccc tctctgcgcg     4440

ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg     4500

cggcctcagt gagcgagcg                                                  4519


<210>  51
<211>  4503
<212>  DNA
<213>  Unknown

<220>
<223>  polynucleotide

<400>  51
cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt tggtcgcccg       60

gcctcagtga gcgagcgagc gcgcagagag ggagtggcca actccatcac taggggttcc      120

tggcgcgccc cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact      180

ttccattgac gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa      240

gtgtatcata tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg      300

cattatgccc agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta      360

gtcatcgcta ttaccatggt cgaggtgagc cccacgttct gcttcactct ccccatctcc      420

cccccctccc cacccccaat tttgtattta tttatttttt aattattttg tgcagcgatg      480

ggggcggggg gggggggggg gcgcgcgcca ggcggggcgg ggcggggcga ggggcggggc      540

ggggcgaggc ggagaggtgc ggcggcagcc aatcagagcg gcgcgctccg aaagtttcct      600

tttatggcga ggcggcggcg gcggcggccc tataaaaagc gaagcgcgcg gcgggcggga      660

gtcgctgcgc gctgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc      720

cggctctgac tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg      780

ggctgtaatt agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc      840

cttgaggggc tccgggaggg ccctttgtgc ggggggagcg gctcggggct gtccgcgggg      900

ggacggctgc cttcgggggg gacggggcag ggcggggttc ggcttctggc gtgtgaccgg      960

cggctctaga gcctctgcta accatgttca tgccttcttc tttttcctac agctcctggg     1020

caacgtgctg gttattgtgc tgtctcatca ttttggcaaa gaattggatc cactagtgcc     1080

accatgcgcc tcctggccaa gatcatctgc ctcatgctgt gggccatctg cgtggctgag     1140

gactgcaatg agctgccgcc caggaggaac acagagatcc tgacagggag ctggtctgac     1200

cagacctacc ctgagggcac ccaggcgatc tacaagtgcc ggccgggcta caggagcctg     1260

gggaacatca tcatggtgtg tagaaagggc gaatgggtgg ccctcaaccc cctgaggaag     1320

tgccagaagc ggccctgtgg ccaccccggg gacacaccct tcgggacctt caccctgacc     1380

ggcggcaatg tgtttgagta cggcgtgaag gctgtctaca catgcaacga ggggtaccag     1440

ctgctgggcg agattaacta ccgggagtgt gacaccgatg ggtggaccaa cgacattccc     1500

atctgtgagg tggtcaagtg tctccccgtg acagccccag aaaatggcaa aatcgtgagc     1560

agcgccatgg agcctgaccg cgaatatcac tttgggcagg ccgtgaggtt tgtgtgcaac     1620

tcgggctaca aaattgaagg tgatgaggag atgcactgca gcgatgatgg cttctggtcc     1680

aaggagaagc ccaaatgtgt ggagatctcc tgcaagtctc ccgacgtgat caacggcagc     1740

ccaatcagcc agaagattat ttacaaagag aacgagcgct tccagtacaa gtgtaacatg     1800

ggctatgagt attcagagag gggagatgcc gtctgcactg agagcggctg gagaccactg     1860

cctagctgcg aggaaaagag ttgtgacaac ccttacatcc caaatggcga ctactcccct     1920

ctgcggatca aacaccggac cggggatgaa atcacctatc agtgccgcaa tggattctac     1980

ccggccaccc gcggcaacac cgccaaatgc accagcacag gctggatccc cgccccccgc     2040

tgtacgctga agccttgcga ctatccagac atcaagcacg gaggcctgta ccacgaaaac     2100

atgcggcggc cttatttccc tgtggcagtg gggaagtact acagctacta ctgcgacgag     2160

cacttcgaga ccccctctgg ctcctactgg gaccacatcc actgcacaca ggacggctgg     2220

tctccagctg tgccctgcct gaggaaatgc tacttcccct acctggagaa cggatacaac     2280

cagaactatg gccgcaagtt cgtgcagggc aagagcatcg atgtggcctg ccaccctggc     2340

tacgccctgc ccaaggccca gacaactgtg acctgcatgg agaatggttg gagccccacc     2400

ccgcgctgca tccgggtgtc cttcacgctc cgaaggaaac gaggaagcgg agaagccaga     2460

cacaaacaga aaattgtggc accggtgaaa cagactttga attttgacct tctcaagttg     2520

gcgggagacg tcgagtccaa ccctgggccc atgcgcctgc tggccaagat catctgcctg     2580

atgctgtggg ccatctgcgt ggccagcgac accggccgcc ccttcgtgga gatgtacagc     2640

gagatccccg agatcatcca catgaccgag ggccgcgagc tggtgatccc ctgccgcgtg     2700

accagcccca acatcaccgt gaccctgaag aagttccccc tggacaccct gatccccgac     2760

ggcaagcgca tcatctggga cagccgcaag ggcttcatca tcagcaacgc cacctacaag     2820

gagatcggcc tgctgacctg cgaggccacc gtgaacggcc acctgtacaa gaccaactac     2880

ctgacccacc gccagaccaa caccatcatc gacgtggtgc tgagccccag ccacggcatc     2940

gagctgagcg tgggcgagaa gctggtgctg aactgcaccg cccgcaccga gctgaacgtg     3000

ggcatcgact tcaactggga gtaccccagc agcaagcacc agcacaagaa gctggtgaac     3060

cgcgacctga agacccagag cggcagcgag atgaagaagt tcctgagcac cctgaccatc     3120

gacggcgtga cccgcagcga ccagggcctg tacacctgcg ccgccagcag cggcctgatg     3180

accaagaaga acagcacctt cgtgcgcgtg cacgagaagg acaagaccca cacctgcccc     3240

ccctgccccg cccccgagct gctgggcggc cccagcgtgt tcctgttccc ccccaagccc     3300

aaggacaccc tgatgatcag ccgcaccccc gaggtgacct gcgtggtggt ggacgtgagc     3360

cacgaggacc ccgaggtgaa gttcaactgg tacgtggacg gcgtggaggt gcacaacgcc     3420

aagaccaagc cccgcgagga gcagtacaac agcacctacc gcgtggtgag cgtgctgacc     3480

gtgctgcacc aggactggct gaacggcaag gagtacaagt gcaaggtgag caacaaggcc     3540

ctgcccgccc ccatcgagaa gaccatcagc aaggccaagg gccagccccg cgagccccag     3600

gtgtacaccc tgccccccag ccgcgacgag ctgaccaaga accaggtgag cctgacctgc     3660

ctggtgaagg gcttctaccc cagcgacatc gccgtggagt gggagagcaa cggccagccc     3720

gagaacaact acaagaccac cccccccgtg ctggacagcg acggcagctt cttcctgtac     3780

agcaagctga ccgtggacaa gagccgctgg cagcagggca acgtgttcag ctgcagcgtg     3840

atgcacgagg ccctgcacaa ccactacacc cagaagagcc tgagcctgag ccccggctaa     3900

ctcgagaatc aacctctgga ttacaaaatt tgtgaaagat tgactggtat tcttaactat     3960

gttgctcctt ttacgctatg tggatacgct gctttaatgc ctttgtatca tgctattgct     4020

tcccgtatgg ctttcatttt ctcctccttg tataaatcct ggttagttct tgccacggcg     4080

gaactcatcg ccgcctgcct tgcccgctgc tggacagggg ctcggctgtt gggcactgac     4140

aattccgtgg tgtgccttct agttgccagc catctgttgt ttgcccctcc cccgtgcctt     4200

ccttgaccct ggaaggtgcc actcccactg tcctttccta ataaaatgag gaaattgcat     4260

cgcattgtct gagtaggtgt cattctattc tggggggtgg ggtggggcag gacagcaagg     4320

gggaggattg ggaagacaat agcaggcatg ctggggatgc ggtgggctct atgggcggcc     4380

gcaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct cgctcactga     4440

ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct cagtgagcga     4500

gcg                                                                   4503


<210>  52
<211>  4503
<212>  DNA
<213>  Unknown

<220>
<223>  polynucleotide

<400>  52
cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt tggtcgcccg       60

gcctcagtga gcgagcgagc gcgcagagag ggagtggcca actccatcac taggggttcc      120

tggcgcgccc cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact      180

ttccattgac gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa      240

gtgtatcata tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg      300

cattatgccc agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta      360

gtcatcgcta ttaccatggt cgaggtgagc cccacgttct gcttcactct ccccatctcc      420

cccccctccc cacccccaat tttgtattta tttatttttt aattattttg tgcagcgatg      480

ggggcggggg gggggggggg gcgcgcgcca ggcggggcgg ggcggggcga ggggcggggc      540

ggggcgaggc ggagaggtgc ggcggcagcc aatcagagcg gcgcgctccg aaagtttcct      600

tttatggcga ggcggcggcg gcggcggccc tataaaaagc gaagcgcgcg gcgggcggga      660

gtcgctgcgc gctgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc      720

cggctctgac tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg      780

ggctgtaatt agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc      840

cttgaggggc tccgggaggg ccctttgtgc ggggggagcg gctcggggct gtccgcgggg      900

ggacggctgc cttcgggggg gacggggcag ggcggggttc ggcttctggc gtgtgaccgg      960

cggctctaga gcctctgcta accatgttca tgccttcttc tttttcctac agctcctggg     1020

caacgtgctg gttattgtgc tgtctcatca ttttggcaaa gaattggatc cactagtgcc     1080

accatgcgcc tgctggccaa gatcatctgc ctgatgctgt gggccatctg cgtggccagc     1140

gacaccggcc gccccttcgt ggagatgtac agcgagatcc ccgagatcat ccacatgacc     1200

gagggccgcg agctggtgat cccctgccgc gtgaccagcc ccaacatcac cgtgaccctg     1260

aagaagttcc ccctggacac cctgatcccc gacggcaagc gcatcatctg ggacagccgc     1320

aagggcttca tcatcagcaa cgccacctac aaggagatcg gcctgctgac ctgcgaggcc     1380

accgtgaacg gccacctgta caagaccaac tacctgaccc accgccagac caacaccatc     1440

atcgacgtgg tgctgagccc cagccacggc atcgagctga gcgtgggcga gaagctggtg     1500

ctgaactgca ccgcccgcac cgagctgaac gtgggcatcg acttcaactg ggagtacccc     1560

agcagcaagc accagcacaa gaagctggtg aaccgcgacc tgaagaccca gagcggcagc     1620

gagatgaaga agttcctgag caccctgacc atcgacggcg tgacccgcag cgaccagggc     1680

ctgtacacct gcgccgccag cagcggcctg atgaccaaga agaacagcac cttcgtgcgc     1740

gtgcacgaga aggacaagac ccacacctgc cccccctgcc ccgcccccga gctgctgggc     1800

ggccccagcg tgttcctgtt cccccccaag cccaaggaca ccctgatgat cagccgcacc     1860

cccgaggtga cctgcgtggt ggtggacgtg agccacgagg accccgaggt gaagttcaac     1920

tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agccccgcga ggagcagtac     1980

aacagcacct accgcgtggt gagcgtgctg accgtgctgc accaggactg gctgaacggc     2040

aaggagtaca agtgcaaggt gagcaacaag gccctgcccg cccccatcga gaagaccatc     2100

agcaaggcca agggccagcc ccgcgagccc caggtgtaca ccctgccccc cagccgcgac     2160

gagctgacca agaaccaggt gagcctgacc tgcctggtga agggcttcta ccccagcgac     2220

atcgccgtgg agtgggagag caacggccag cccgagaaca actacaagac cacccccccc     2280

gtgctggaca gcgacggcag cttcttcctg tacagcaagc tgaccgtgga caagagccgc     2340

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac     2400

acccagaaga gcctgagcct gagccccggc taacgaagga aacgaggaag cggagaagcc     2460

agacacaaac agaaaattgt ggcaccggtg aaacagactt tgaattttga ccttctcaag     2520

ttggcgggag acgtcgagtc caaccctggg cccatgcgcc tcctggccaa gatcatctgc     2580

ctcatgctgt gggccatctg cgtggctgag gactgcaatg agctgccgcc caggaggaac     2640

acagagatcc tgacagggag ctggtctgac cagacctacc ctgagggcac ccaggcgatc     2700

tacaagtgcc ggccgggcta caggagcctg gggaacatca tcatggtgtg tagaaagggc     2760

gaatgggtgg ccctcaaccc cctgaggaag tgccagaagc ggccctgtgg ccaccccggg     2820

gacacaccct tcgggacctt caccctgacc ggcggcaatg tgtttgagta cggcgtgaag     2880

gctgtctaca catgcaacga ggggtaccag ctgctgggcg agattaacta ccgggagtgt     2940

gacaccgatg ggtggaccaa cgacattccc atctgtgagg tggtcaagtg tctccccgtg     3000

acagccccag aaaatggcaa aatcgtgagc agcgccatgg agcctgaccg cgaatatcac     3060

tttgggcagg ccgtgaggtt tgtgtgcaac tcgggctaca aaattgaagg tgatgaggag     3120

atgcactgca gcgatgatgg cttctggtcc aaggagaagc ccaaatgtgt ggagatctcc     3180

tgcaagtctc ccgacgtgat caacggcagc ccaatcagcc agaagattat ttacaaagag     3240

aacgagcgct tccagtacaa gtgtaacatg ggctatgagt attcagagag gggagatgcc     3300

gtctgcactg agagcggctg gagaccactg cctagctgcg aggaaaagag ttgtgacaac     3360

ccttacatcc caaatggcga ctactcccct ctgcggatca aacaccggac cggggatgaa     3420

atcacctatc agtgccgcaa tggattctac ccggccaccc gcggcaacac cgccaaatgc     3480

accagcacag gctggatccc cgccccccgc tgtacgctga agccttgcga ctatccagac     3540

atcaagcacg gaggcctgta ccacgaaaac atgcggcggc cttatttccc tgtggcagtg     3600

gggaagtact acagctacta ctgcgacgag cacttcgaga ccccctctgg ctcctactgg     3660

gaccacatcc actgcacaca ggacggctgg tctccagctg tgccctgcct gaggaaatgc     3720

tacttcccct acctggagaa cggatacaac cagaactatg gccgcaagtt cgtgcagggc     3780

aagagcatcg atgtggcctg ccaccctggc tacgccctgc ccaaggccca gacaactgtg     3840

acctgcatgg agaatggttg gagccccacc ccgcgctgca tccgggtgtc cttcacgctc     3900

ctcgagaatc aacctctgga ttacaaaatt tgtgaaagat tgactggtat tcttaactat     3960

gttgctcctt ttacgctatg tggatacgct gctttaatgc ctttgtatca tgctattgct     4020

tcccgtatgg ctttcatttt ctcctccttg tataaatcct ggttagttct tgccacggcg     4080

gaactcatcg ccgcctgcct tgcccgctgc tggacagggg ctcggctgtt gggcactgac     4140

aattccgtgg tgtgccttct agttgccagc catctgttgt ttgcccctcc cccgtgcctt     4200

ccttgaccct ggaaggtgcc actcccactg tcctttccta ataaaatgag gaaattgcat     4260

cgcattgtct gagtaggtgt cattctattc tggggggtgg ggtggggcag gacagcaagg     4320

gggaggattg ggaagacaat agcaggcatg ctggggatgc ggtgggctct atgggcggcc     4380

gcaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct cgctcactga     4440

ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct cagtgagcga     4500

gcg                                                                   4503


<210>  53
<211>  4258
<212>  DNA
<213>  Unknown

<220>
<223>  polynucleotide

<400>  53
cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt tggtcgcccg       60

gcctcagtga gcgagcgagc gcgcagagag ggagtggcca actccatcac taggggttcc      120

tggcgcgccc cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact      180

ttccattgac gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa      240

gtgtatcata tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg      300

cattatgccc agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta      360

gtcatcgcta ttaccatggt cgaggtgagc cccacgttct gcttcactct ccccatctcc      420

cccccctccc cacccccaat tttgtattta tttatttttt aattattttg tgcagcgatg      480

ggggcggggg gggggggggg gcgcgcgcca ggcggggcgg ggcggggcga ggggcggggc      540

ggggcgaggc ggagaggtgc ggcggcagcc aatcagagcg gcgcgctccg aaagtttcct      600

tttatggcga ggcggcggcg gcggcggccc tataaaaagc gaagcgcgcg gcgggcggga      660

gtcgctgcgc gctgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc      720

cggctctgac tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg      780

ggctgtaatt agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc      840

cttgaggggc tccgggaggg ccctttgtgc ggggggagcg gctcggggct gtccgcgggg      900

ggacggctgc cttcgggggg gacggggcag ggcggggttc ggcttctggc gtgtgaccgg      960

cggctctaga gcctctgcta accatgttca tgccttcttc tttttcctac agctcctggg     1020

caacgtgctg gttattgtgc tgtctcatca ttttggcaaa gaattggatc cactagtgcc     1080

accatgcgcc tcctggccaa gatcatctgc ctcatgctgt gggccatctg cgtggctgag     1140

gactgcaatg agctgccgcc caggaggaac acagagatcc tgacagggag ctggtctgac     1200

cagacctacc ctgagggcac ccaggcgatc tacaagtgcc ggccgggcta caggagcctg     1260

gggaacatca tcatggtgtg tagaaagggc gaatgggtgg ccctcaaccc cctgaggaag     1320

tgccagaagc ggccctgtgg ccaccccggg gacacaccct tcgggacctt caccctgacc     1380

ggcggcaatg tgtttgagta cggcgtgaag gctgtctaca catgcaacga ggggtaccag     1440

ctgctgggcg agattaacta ccgggagtgt gacaccgatg ggtggaccaa cgacattccc     1500

atctgtgagg tggtcaagtg tctccccgtg acagccccag aaaatggcaa aatcgtgagc     1560

agcgccatgg agcctgaccg cgaatatcac tttgggcagg ccgtgaggtt tgtgtgcaac     1620

tcgggctaca aaattgaagg tgatgaggag atgcactgca gcgatgatgg cttctggtcc     1680

aaggagaagc ccaaatgtgt ggagatctcc tgcaagtctc ccgacgtgat caacggcagc     1740

ccaatcagcc agaagattat ttacaaagag aacgagcgct tccagtacaa gtgtaacatg     1800

ggctatgagt attcagagag gggagatgcc gtctgcactg agagcggctg gagaccactg     1860

cctagctgcg aggaaaagag ttgtgacaac ccttacatcc caaatggcga ctactcccct     1920

ctgcggatca aacaccggac cggggatgaa atcacctatc agtgccgcaa tggattctac     1980

ccggccaccc gcggcaacac cgccaaatgc accagcacag gctggatccc cgccccccgc     2040

tgtacgctga agccttgcga ctatccagac atcaagcacg gaggcctgta ccacgaaaac     2100

atgcggcggc cttatttccc tgtggcagtg gggaagtact acagctacta ctgcgacgag     2160

cacttcgaga ccccctctgg ctcctactgg gaccacatcc actgcacaca ggacggctgg     2220

tctccagctg tgccctgcct gaggaaatgc tacttcccct acctggagaa cggatacaac     2280

cagaactatg gccgcaagtt cgtgcagggc aagagcatcg atgtggcctg ccaccctggc     2340

tacgccctgc ccaaggccca gacaactgtg acctgcatgg agaatggttg gagccccacc     2400

ccgcgctgca tccgggtgtc cttcacgctc cgaaggaaac gaggaagcgg agaagccaga     2460

cacaaacaga aaattgtggc accggtgaaa cagactttga attttgacct tctcaagttg     2520

gcgggagacg tcgagtccaa ccctgggccc atgcgcctgc tggccaagat catctgcctg     2580

atgctgtggg ccatctgcgt ggccagcgac accggccgcc ccttcgtgga gatgtacagc     2640

gagatccccg agatcatcca catgaccgag ggccgcgagc tggtgatccc ctgccgcgtg     2700

accagcccca acatcaccgt gaccctgaag aagttccccc tggacaccct gatccccgac     2760

ggcaagcgca tcatctggga cagccgcaag ggcttcatca tcagcaacgc cacctacaag     2820

gagatcggcc tgctgacctg cgaggccacc gtgaacggcc acctgtacaa gaccaactac     2880

ctgacccacc gccagaccaa caccatcatc gacgtggtgc tgagccccag ccacggcatc     2940

gagctgagcg tgggcgagaa gctggtgctg aactgcaccg cccgcaccga gctgaacgtg     3000

ggcatcgact tcaactggga gtaccccagc agcaagcacc agcacaagaa gctggtgaac     3060

cgcgacctga agacccagag cggcagcgag atgaagaagt tcctgagcac cctgaccatc     3120

gacggcgtga cccgcagcga ccagggcctg tacacctgcg ccgccagcag cggcctgatg     3180

accaagaaga acagcacctt cgtgcgcgtg cacgagaagg acaagaccca cacctgcccc     3240

ccctgccccg cccccgagct gctgggcggc cccagcgtgt tcctgttccc ccccaagccc     3300

aaggacaccc tgatgatcag ccgcaccccc gaggtgacct gcgtggtggt ggacgtgagc     3360

cacgaggacc ccgaggtgaa gttcaactgg tacgtggacg gcgtggaggt gcacaacgcc     3420

aagaccaagc cccgcgagga gcagtacaac agcacctacc gcgtggtgag cgtgctgacc     3480

gtgctgcacc aggactggct gaacggcaag gagtacaagt gcaaggtgag caacaaggcc     3540

ctgcccgccc ccatcgagaa gaccatcagc aaggccaagg gccagccccg cgagccccag     3600

gtgtacaccc tgccccccag ccgcgacgag ctgaccaaga accaggtgag cctgacctgc     3660

ctggtgaagg gcttctaccc cagcgacatc gccgtggagt gggagagcaa cggccagccc     3720

gagaacaact acaagaccac cccccccgtg ctggacagcg acggcagctt cttcctgtac     3780

agcaagctga ccgtggacaa gagccgctgg cagcagggca acgtgttcag ctgcagcgtg     3840

atgcacgagg ccctgcacaa ccactacacc cagaagagcc tgagcctgag ccccggctaa     3900

ctcgaggtgc cttctagttg ccagccatct gttgtttgcc cctcccccgt gccttccttg     3960

accctggaag gtgccactcc cactgtcctt tcctaataaa atgaggaaat tgcatcgcat     4020

tgtctgagta ggtgtcattc tattctgggg ggtggggtgg ggcaggacag caagggggag     4080

gattgggaag acaatagcag gcatgctggg gatgcggtgg gctctatggg cggccgcagg     4140

aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg     4200

ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg agcgagcg       4258


<210>  54
<211>  4258
<212>  DNA
<213>  Unknown

<220>
<223>  polynucleotide

<400>  54
cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt tggtcgcccg       60

gcctcagtga gcgagcgagc gcgcagagag ggagtggcca actccatcac taggggttcc      120

tggcgcgccc cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact      180

ttccattgac gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa      240

gtgtatcata tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg      300

cattatgccc agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta      360

gtcatcgcta ttaccatggt cgaggtgagc cccacgttct gcttcactct ccccatctcc      420

cccccctccc cacccccaat tttgtattta tttatttttt aattattttg tgcagcgatg      480

ggggcggggg gggggggggg gcgcgcgcca ggcggggcgg ggcggggcga ggggcggggc      540

ggggcgaggc ggagaggtgc ggcggcagcc aatcagagcg gcgcgctccg aaagtttcct      600

tttatggcga ggcggcggcg gcggcggccc tataaaaagc gaagcgcgcg gcgggcggga      660

gtcgctgcgc gctgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc      720

cggctctgac tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg      780

ggctgtaatt agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc      840

cttgaggggc tccgggaggg ccctttgtgc ggggggagcg gctcggggct gtccgcgggg      900

ggacggctgc cttcgggggg gacggggcag ggcggggttc ggcttctggc gtgtgaccgg      960

cggctctaga gcctctgcta accatgttca tgccttcttc tttttcctac agctcctggg     1020

caacgtgctg gttattgtgc tgtctcatca ttttggcaaa gaattggatc cactagtgcc     1080

accatgcgcc tgctggccaa gatcatctgc ctgatgctgt gggccatctg cgtggccagc     1140

gacaccggcc gccccttcgt ggagatgtac agcgagatcc ccgagatcat ccacatgacc     1200

gagggccgcg agctggtgat cccctgccgc gtgaccagcc ccaacatcac cgtgaccctg     1260

aagaagttcc ccctggacac cctgatcccc gacggcaagc gcatcatctg ggacagccgc     1320

aagggcttca tcatcagcaa cgccacctac aaggagatcg gcctgctgac ctgcgaggcc     1380

accgtgaacg gccacctgta caagaccaac tacctgaccc accgccagac caacaccatc     1440

atcgacgtgg tgctgagccc cagccacggc atcgagctga gcgtgggcga gaagctggtg     1500

ctgaactgca ccgcccgcac cgagctgaac gtgggcatcg acttcaactg ggagtacccc     1560

agcagcaagc accagcacaa gaagctggtg aaccgcgacc tgaagaccca gagcggcagc     1620

gagatgaaga agttcctgag caccctgacc atcgacggcg tgacccgcag cgaccagggc     1680

ctgtacacct gcgccgccag cagcggcctg atgaccaaga agaacagcac cttcgtgcgc     1740

gtgcacgaga aggacaagac ccacacctgc cccccctgcc ccgcccccga gctgctgggc     1800

ggccccagcg tgttcctgtt cccccccaag cccaaggaca ccctgatgat cagccgcacc     1860

cccgaggtga cctgcgtggt ggtggacgtg agccacgagg accccgaggt gaagttcaac     1920

tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agccccgcga ggagcagtac     1980

aacagcacct accgcgtggt gagcgtgctg accgtgctgc accaggactg gctgaacggc     2040

aaggagtaca agtgcaaggt gagcaacaag gccctgcccg cccccatcga gaagaccatc     2100

agcaaggcca agggccagcc ccgcgagccc caggtgtaca ccctgccccc cagccgcgac     2160

gagctgacca agaaccaggt gagcctgacc tgcctggtga agggcttcta ccccagcgac     2220

atcgccgtgg agtgggagag caacggccag cccgagaaca actacaagac cacccccccc     2280

gtgctggaca gcgacggcag cttcttcctg tacagcaagc tgaccgtgga caagagccgc     2340

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac     2400

acccagaaga gcctgagcct gagccccggc taacgaagga aacgaggaag cggagaagcc     2460

agacacaaac agaaaattgt ggcaccggtg aaacagactt tgaattttga ccttctcaag     2520

ttggcgggag acgtcgagtc caaccctggg cccatgcgcc tcctggccaa gatcatctgc     2580

ctcatgctgt gggccatctg cgtggctgag gactgcaatg agctgccgcc caggaggaac     2640

acagagatcc tgacagggag ctggtctgac cagacctacc ctgagggcac ccaggcgatc     2700

tacaagtgcc ggccgggcta caggagcctg gggaacatca tcatggtgtg tagaaagggc     2760

gaatgggtgg ccctcaaccc cctgaggaag tgccagaagc ggccctgtgg ccaccccggg     2820

gacacaccct tcgggacctt caccctgacc ggcggcaatg tgtttgagta cggcgtgaag     2880

gctgtctaca catgcaacga ggggtaccag ctgctgggcg agattaacta ccgggagtgt     2940

gacaccgatg ggtggaccaa cgacattccc atctgtgagg tggtcaagtg tctccccgtg     3000

acagccccag aaaatggcaa aatcgtgagc agcgccatgg agcctgaccg cgaatatcac     3060

tttgggcagg ccgtgaggtt tgtgtgcaac tcgggctaca aaattgaagg tgatgaggag     3120

atgcactgca gcgatgatgg cttctggtcc aaggagaagc ccaaatgtgt ggagatctcc     3180

tgcaagtctc ccgacgtgat caacggcagc ccaatcagcc agaagattat ttacaaagag     3240

aacgagcgct tccagtacaa gtgtaacatg ggctatgagt attcagagag gggagatgcc     3300

gtctgcactg agagcggctg gagaccactg cctagctgcg aggaaaagag ttgtgacaac     3360

ccttacatcc caaatggcga ctactcccct ctgcggatca aacaccggac cggggatgaa     3420

atcacctatc agtgccgcaa tggattctac ccggccaccc gcggcaacac cgccaaatgc     3480

accagcacag gctggatccc cgccccccgc tgtacgctga agccttgcga ctatccagac     3540

atcaagcacg gaggcctgta ccacgaaaac atgcggcggc cttatttccc tgtggcagtg     3600

gggaagtact acagctacta ctgcgacgag cacttcgaga ccccctctgg ctcctactgg     3660

gaccacatcc actgcacaca ggacggctgg tctccagctg tgccctgcct gaggaaatgc     3720

tacttcccct acctggagaa cggatacaac cagaactatg gccgcaagtt cgtgcagggc     3780

aagagcatcg atgtggcctg ccaccctggc tacgccctgc ccaaggccca gacaactgtg     3840

acctgcatgg agaatggttg gagccccacc ccgcgctgca tccgggtgtc cttcacgctc     3900

ctcgaggtgc cttctagttg ccagccatct gttgtttgcc cctcccccgt gccttccttg     3960

accctggaag gtgccactcc cactgtcctt tcctaataaa atgaggaaat tgcatcgcat     4020

tgtctgagta ggtgtcattc tattctgggg ggtggggtgg ggcaggacag caagggggag     4080

gattgggaag acaatagcag gcatgctggg gatgcggtgg gctctatggg cggccgcagg     4140

aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg     4200

ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg agcgagcg       4258


<210>  55
<211>  121
<212>  DNA
<213>  Unknown

<220>
<223>  5' AAV ITR

<400>  55
cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt tggtcgcccg       60

gcctcagtga gcgagcgagc gcgcagagag ggagtggcca actccatcac taggggttcc      120

t                                                                      121


<210>  56
<211>  57
<212>  DNA
<213>  Unknown

<220>
<223>  sequence immediately adjacent to the 3' end of the 5' ITR

<400>  56
tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct aggtacc          57


<210>  57
<211>  121
<212>  DNA
<213>  Unknown

<220>
<223>  3' AAV ITR

<400>  57
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

g                                                                      121


<210>  58
<211>  85
<212>  DNA
<213>  Unknown

<220>
<223>  nucleotide sequence

<400>  58
cttctgaggc ggaaagaacc agctggggct cgactagagc atggctacgt agataagtag       60

catggcgggt taatcattaa ctaca                                             85


<210>  59
<211>  585
<212>  DNA
<213>  Unknown

<220>
<223>  CMV promoter

<400>  59
ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc       60

ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca      120

ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac atcaagtgta      180

tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta      240

tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg tattagtcat      300

cgctattacc atggtgatgc ggttttggca gtacatcaat gggcgtggat agcggtttga      360

ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt tttggcacca      420

aaatcaacgg gactttccaa aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg      480

taggcgtgta cggtgggagg tctatataag cagagctcgt ttagtgaacc gtcagatcgc      540

ctggagacgc catccacgct gttttgacct ccatagaaga caccg                      585


<210>  60
<211>  942
<212>  DNA
<213>  Unknown

<220>
<223>  CAG promoter

<400>  60
ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac tttccattga       60

cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat      120

atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc      180

cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt agtcatcgct      240

attaccatgg tcgaggtgag ccccacgttc tgcttcactc tccccatctc ccccccctcc      300

ccacccccaa ttttgtattt atttattttt taattatttt gtgcagcgat gggggcgggg      360

gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg cggggcgagg      420

cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc ttttatggcg      480

aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg agtcgctgcg      540

cgctgccttc gccccgtgcc ccgctccgcc gccgcctcgc gccgcccgcc ccggctctga      600

ctgaccgcgt tactcccaca ggtgagcggg cgggacggcc cttctcctcc gggctgtaat      660

tagcgcttgg tttaatgacg gcttgtttct tttctgtggc tgcgtgaaag ccttgagggg      720

ctccgggagg gccctttgtg cggggggagc ggctcggggc tgtccgcggg gggacggctg      780

ccttcggggg ggacggggca gggcggggtt cggcttctgg cgtgtgaccg gcggctctag      840

agcctctgct aaccatgttc atgccttctt ctttttccta cagctcctgg gcaacgtgct      900

ggttattgtg ctgtctcatc attttggcaa agaattggat cc                         942


<210>  61
<211>  223
<212>  DNA
<213>  Unknown

<220>
<223>  example Bovine Growth Hormone poly-A (bGH poly-A) signal

<400>  61
gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc cttgaccctg       60

gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc gcattgtctg      120

agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg ggaggattgg      180

gaagacaata gcaggcatgc tggggatgcg gtgggctcta tgg                        223


<210>  62
<211>  270
<212>  DNA
<213>  Unknown

<220>
<223>  example Bovine Growth Hormone poly-A (bGH poly-A) signal

<400>  62
tcgctgatca gcctcgactg tgccttctag ttgccagcca tctgttgttt gcccctcccc       60

cgtgccttcc ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga      120

aattgcatcg cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga      180

cagcaagggg gaggattggg aagacaatag caggcatgct ggggatgcgg tgggctctat      240

ggcttctgag gcggaaagaa ccagctgggg                                       270


<210>  63
<211>  588
<212>  DNA
<213>  Unknown

<220>
<223>  woodchuck hepatitis post-transcriptional regulatory element 
       (WPRE)

<400>  63
atcaacctct ggattacaaa atttgtgaaa gattgactgg tattcttaac tatgttgctc       60

cttttacgct atgtggatac gctgctttaa tgcctttgta tcatgctatt gcttcccgta      120

tggctttcat tttctcctcc ttgtataaat cctggttgct gtctctttat gaggagttgt      180

ggcccgttgt caggcaacgt ggcgtggtgt gcactgtgtt tgctgacgca acccccactg      240

gttggggcat tgccaccacc tgtcagctcc tttccgggac tttcgctttc cccctcccta      300

ttgccacggc ggaactcatc gccgcctgcc ttgcccgctg ctggacaggg gctcggctgt      360

tgggcactga caattccgtg gtgttgtcgg ggaaatcatc gtcctttcct tggctgctcg      420

cctgtgttgc cacctggatt ctgcgcggga cgtccttctg ctacgtccct tcggccctca      480

atccagcgga ccttccttcc cgcggcctgc tgccggctct gcggcctctt ccgcgtcttc      540

gccttcgccc tcagacgagt cggatctccc tttgggccgc ctccccgc                   588


<210>  64
<211>  245
<212>  DNA
<213>  Unknown

<220>
<223>  WPRE3

<400>  64
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct       60

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt      120

atggctttca ttttctcctc cttgtataaa tcctggttag ttcttgccac ggcggaactc      180

atcgccgcct gccttgcccg ctgctggaca ggggctcggc tgttgggcac tgacaattcc      240

gtggt                                                                  245


<210>  65
<211>  145
<212>  DNA
<213>  Unknown

<220>
<223>  5' AAV ITR

<400>  65
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgcccgggc aaagcccggg cgtcgggcga cctttggtcg cccggcctca gtgagcgagc      120

gagcgcgcag agagggagtg gccaa                                            145


<210>  66
<211>  145
<212>  DNA
<213>  Unknown

<220>
<223>  3' AAV ITR

<400>  66
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag agagggagtg gccaa                                            145


<210>  67
<211>  21
<212>  DNA
<213>  Unknown

<220>
<223>  bGHpA FR primer

<400>  67
catcgcattg tctgagtagg t                                                 21


<210>  68
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  bGHpA Rv primer

<400>  68
agcatgcctg ctattgtctt                                                   20


