                         SEQUENCE LISTING

<110>  Imperial College Innovations Limited
 
<120>  Proteome Analysis in Pulmonary Hypertension

<130>  P68093WO

<150>  GB 2016349.9
<151>  2020-10-15

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  923
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Val Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser 
                645                 650                 655     


His Lys Thr Phe Cys His Trp Glu His Asp Asn His Val Gln Leu Lys 
            660                 665                 670         


Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly 
        675                 680                 685             


Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys 
    690                 695                 700                 


Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His 
705                 710                 715                 720 


Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly Thr Leu 
                725                 730                 735     


Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val 
            740                 745                 750         


Trp Met Ala Ile Gly His Gln Gly Asp His Trp Lys Glu Gly Arg Val 
        755                 760                 765             


Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu 
    770                 775                 780                 


Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile 
785                 790                 795                 800 


Asn Asn His Ile Ser Gln Glu Asp Cys Ala Lys Pro Ala Asp Leu Asp 
                805                 810                 815     


Lys Lys Asn Pro Glu Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly 
            820                 825                 830         


Tyr Glu Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly 
        835                 840                 845             


Asn Val Leu Lys Thr Leu Asp Pro Ile Leu Ile Thr Ile Ile Ala Met 
    850                 855                 860                 


Ser Ala Leu Gly Val Leu Leu Gly Ala Val Cys Gly Val Val Leu Tyr 
865                 870                 875                 880 


Cys Ala Cys Trp His Asn Gly Met Ser Glu Arg Asn Leu Ser Ala Leu 
                885                 890                 895     


Glu Asn Tyr Asn Phe Glu Leu Val Asp Gly Val Lys Leu Lys Lys Asp 
            900                 905                 910         


Lys Leu Asn Thr Gln Ser Thr Tyr Ser Glu Ala 
        915                 920             


<210>  2
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Ala Leu Pro Leu Leu Ala Ala Thr Thr Pro Asp His Gly Arg 
1               5                   10                  15      


His Arg Arg Leu Leu Leu Leu Pro Leu Leu Leu Phe Leu Leu Pro Ala 
            20                  25                  30          


Gly Ala Val Gln Gly Trp Glu Thr Glu Glu Arg Pro Arg Thr Arg Glu 
        35                  40                  45              


Glu Glu Cys His Phe Tyr Ala Gly Gly Gln Val Tyr Pro Gly Glu Ala 
    50                  55                  60                  


Ser Arg Val Ser Val Ala Asp His Ser Leu His Leu Ser Lys Ala Lys 
65                  70                  75                  80  


Ile Ser Lys Pro Ala Pro Tyr Trp Glu Gly Thr Ala Val Ile Asp Gly 
                85                  90                  95      


Glu Phe Lys Glu Leu Lys Leu Thr Asp Tyr Arg Gly Lys Tyr Leu Val 
            100                 105                 110         


Phe Phe Phe Tyr Pro Leu Asp Phe Thr Phe Val Cys Pro Thr Glu Ile 
        115                 120                 125             


Ile Ala Phe Gly Asp Arg Leu Glu Glu Phe Arg Ser Ile Asn Thr Glu 
    130                 135                 140                 


Val Val Ala Cys Ser Val Asp Ser Gln Phe Thr His Leu Ala Trp Ile 
145                 150                 155                 160 


Asn Thr Pro Arg Arg Gln Gly Gly Leu Gly Pro Ile Arg Ile Pro Leu 
                165                 170                 175     


Leu Ser Asp Leu Thr His Gln Ile Ser Lys Asp Tyr Gly Val Tyr Leu 
            180                 185                 190         


Glu Asp Ser Gly His Thr Leu Arg Gly Leu Phe Ile Ile Asp Asp Lys 
        195                 200                 205             


Gly Ile Leu Arg Gln Ile Thr Leu Asn Asp Leu Pro Val Gly Arg Ser 
    210                 215                 220                 


Val Asp Glu Thr Leu Arg Leu Val Gln Ala Phe Gln Tyr Thr Asp Lys 
225                 230                 235                 240 


His Gly Glu Val Cys Pro Ala Gly Trp Lys Pro Gly Ser Glu Thr Ile 
                245                 250                 255     


Ile Pro Asp Pro Ala Gly Lys Leu Lys Tyr Phe Asp Lys Leu Asn 
            260                 265                 270     


<210>  3
<211>  1479
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Lys Arg Ser Arg Gly Pro Gly Arg Arg Cys Leu Leu Ala Leu 
1               5                   10                  15      


Val Leu Phe Cys Ala Trp Gly Thr Leu Ala Val Val Ala Gln Lys Pro 
            20                  25                  30          


Gly Ala Gly Cys Pro Ser Arg Cys Leu Cys Phe Arg Thr Thr Val Arg 
        35                  40                  45              


Cys Met His Leu Leu Leu Glu Ala Val Pro Ala Val Ala Pro Gln Thr 
    50                  55                  60                  


Ser Ile Leu Asp Leu Arg Phe Asn Arg Ile Arg Glu Ile Gln Pro Gly 
65                  70                  75                  80  


Ala Phe Arg Arg Leu Arg Asn Leu Asn Thr Leu Leu Leu Asn Asn Asn 
                85                  90                  95      


Gln Ile Lys Arg Ile Pro Ser Gly Ala Phe Glu Asp Leu Glu Asn Leu 
            100                 105                 110         


Lys Tyr Leu Tyr Leu Tyr Lys Asn Glu Ile Gln Ser Ile Asp Arg Gln 
        115                 120                 125             


Ala Phe Lys Gly Leu Ala Ser Leu Glu Gln Leu Tyr Leu His Phe Asn 
    130                 135                 140                 


Gln Ile Glu Thr Leu Asp Pro Asp Ser Phe Gln His Leu Pro Lys Leu 
145                 150                 155                 160 


Glu Arg Leu Phe Leu His Asn Asn Arg Ile Thr His Leu Val Pro Gly 
                165                 170                 175     


Thr Phe Asn His Leu Glu Ser Met Lys Arg Leu Arg Leu Asp Ser Asn 
            180                 185                 190         


Thr Leu His Cys Asp Cys Glu Ile Leu Trp Leu Ala Asp Leu Leu Lys 
        195                 200                 205             


Thr Tyr Ala Glu Ser Gly Asn Ala Gln Ala Ala Ala Ile Cys Glu Tyr 
    210                 215                 220                 


Pro Arg Arg Ile Gln Gly Arg Ser Val Ala Thr Ile Thr Pro Glu Glu 
225                 230                 235                 240 


Leu Asn Cys Glu Arg Pro Arg Ile Thr Ser Glu Pro Gln Asp Ala Asp 
                245                 250                 255     


Val Thr Ser Gly Asn Thr Val Tyr Phe Thr Cys Arg Ala Glu Gly Asn 
            260                 265                 270         


Pro Lys Pro Glu Ile Ile Trp Leu Arg Asn Asn Asn Glu Leu Ser Met 
        275                 280                 285             


Lys Thr Asp Ser Arg Leu Asn Leu Leu Asp Asp Gly Thr Leu Met Ile 
    290                 295                 300                 


Gln Asn Thr Gln Glu Thr Asp Gln Gly Ile Tyr Gln Cys Met Ala Lys 
305                 310                 315                 320 


Asn Val Ala Gly Glu Val Lys Thr Gln Glu Val Thr Leu Arg Tyr Phe 
                325                 330                 335     


Gly Ser Pro Ala Arg Pro Thr Phe Val Ile Gln Pro Gln Asn Thr Glu 
            340                 345                 350         


Val Leu Val Gly Glu Ser Val Thr Leu Glu Cys Ser Ala Thr Gly His 
        355                 360                 365             


Pro Pro Pro Arg Ile Ser Trp Thr Arg Gly Asp Arg Thr Pro Leu Pro 
    370                 375                 380                 


Val Asp Pro Arg Val Asn Ile Thr Pro Ser Gly Gly Leu Tyr Ile Gln 
385                 390                 395                 400 


Asn Val Val Gln Gly Asp Ser Gly Glu Tyr Ala Cys Ser Ala Thr Asn 
                405                 410                 415     


Asn Ile Asp Ser Val His Ala Thr Ala Phe Ile Ile Val Gln Ala Leu 
            420                 425                 430         


Pro Gln Phe Thr Val Thr Pro Gln Asp Arg Val Val Ile Glu Gly Gln 
        435                 440                 445             


Thr Val Asp Phe Gln Cys Glu Ala Lys Gly Asn Pro Pro Pro Val Ile 
    450                 455                 460                 


Ala Trp Thr Lys Gly Gly Ser Gln Leu Ser Val Asp Arg Arg His Leu 
465                 470                 475                 480 


Val Leu Ser Ser Gly Thr Leu Arg Ile Ser Gly Val Ala Leu His Asp 
                485                 490                 495     


Gln Gly Gln Tyr Glu Cys Gln Ala Val Asn Ile Ile Gly Ser Gln Lys 
            500                 505                 510         


Val Val Ala His Leu Thr Val Gln Pro Arg Val Thr Pro Val Phe Ala 
        515                 520                 525             


Ser Ile Pro Ser Asp Thr Thr Val Glu Val Gly Ala Asn Val Gln Leu 
    530                 535                 540                 


Pro Cys Ser Ser Gln Gly Glu Pro Glu Pro Ala Ile Thr Trp Asn Lys 
545                 550                 555                 560 


Asp Gly Val Gln Val Thr Glu Ser Gly Lys Phe His Ile Ser Pro Glu 
                565                 570                 575     


Gly Phe Leu Thr Ile Asn Asp Val Gly Pro Ala Asp Ala Gly Arg Tyr 
            580                 585                 590         


Glu Cys Val Ala Arg Asn Thr Ile Gly Ser Ala Ser Val Ser Met Val 
        595                 600                 605             


Leu Ser Val Asn Val Pro Asp Val Ser Arg Asn Gly Asp Pro Phe Val 
    610                 615                 620                 


Ala Thr Ser Ile Val Glu Ala Ile Ala Thr Val Asp Arg Ala Ile Asn 
625                 630                 635                 640 


Ser Thr Arg Thr His Leu Phe Asp Ser Arg Pro Arg Ser Pro Asn Asp 
                645                 650                 655     


Leu Leu Ala Leu Phe Arg Tyr Pro Arg Asp Pro Tyr Thr Val Glu Gln 
            660                 665                 670         


Ala Arg Ala Gly Glu Ile Phe Glu Arg Thr Leu Gln Leu Ile Gln Glu 
        675                 680                 685             


His Val Gln His Gly Leu Met Val Asp Leu Asn Gly Thr Ser Tyr His 
    690                 695                 700                 


Tyr Asn Asp Leu Val Ser Pro Gln Tyr Leu Asn Leu Ile Ala Asn Leu 
705                 710                 715                 720 


Ser Gly Cys Thr Ala His Arg Arg Val Asn Asn Cys Ser Asp Met Cys 
                725                 730                 735     


Phe His Gln Lys Tyr Arg Thr His Asp Gly Thr Cys Asn Asn Leu Gln 
            740                 745                 750         


His Pro Met Trp Gly Ala Ser Leu Thr Ala Phe Glu Arg Leu Leu Lys 
        755                 760                 765             


Ser Val Tyr Glu Asn Gly Phe Asn Thr Pro Arg Gly Ile Asn Pro His 
    770                 775                 780                 


Arg Leu Tyr Asn Gly His Ala Leu Pro Met Pro Arg Leu Val Ser Thr 
785                 790                 795                 800 


Thr Leu Ile Gly Thr Glu Thr Val Thr Pro Asp Glu Gln Phe Thr His 
                805                 810                 815     


Met Leu Met Gln Trp Gly Gln Phe Leu Asp His Asp Leu Asp Ser Thr 
            820                 825                 830         


Val Val Ala Leu Ser Gln Ala Arg Phe Ser Asp Gly Gln His Cys Ser 
        835                 840                 845             


Asn Val Cys Ser Asn Asp Pro Pro Cys Phe Ser Val Met Ile Pro Pro 
    850                 855                 860                 


Asn Asp Ser Arg Ala Arg Ser Gly Ala Arg Cys Met Phe Phe Val Arg 
865                 870                 875                 880 


Ser Ser Pro Val Cys Gly Ser Gly Met Thr Ser Leu Leu Met Asn Ser 
                885                 890                 895     


Val Tyr Pro Arg Glu Gln Ile Asn Gln Leu Thr Ser Tyr Ile Asp Ala 
            900                 905                 910         


Ser Asn Val Tyr Gly Ser Thr Glu His Glu Ala Arg Ser Ile Arg Asp 
        915                 920                 925             


Leu Ala Ser His Arg Gly Leu Leu Arg Gln Gly Ile Val Gln Arg Ser 
    930                 935                 940                 


Gly Lys Pro Leu Leu Pro Phe Ala Thr Gly Pro Pro Thr Glu Cys Met 
945                 950                 955                 960 


Arg Asp Glu Asn Glu Ser Pro Ile Pro Cys Phe Leu Ala Gly Asp His 
                965                 970                 975     


Arg Ala Asn Glu Gln Leu Gly Leu Thr Ser Met His Thr Leu Trp Phe 
            980                 985                 990         


Arg Glu His Asn Arg Ile Ala Thr  Glu Leu Leu Lys Leu  Asn Pro His 
        995                 1000                 1005             


Trp Asp  Gly Asp Thr Ile Tyr  Tyr Glu Thr Arg Lys  Ile Val Gly 
    1010                 1015                 1020             


Ala Glu  Ile Gln His Ile Thr  Tyr Gln His Trp Leu  Pro Lys Ile 
    1025                 1030                 1035             


Leu Gly  Glu Val Gly Met Arg  Thr Leu Gly Glu Tyr  His Gly Tyr 
    1040                 1045                 1050             


Asp Pro  Gly Ile Asn Ala Gly  Ile Phe Asn Ala Phe  Ala Thr Ala 
    1055                 1060                 1065             


Ala Phe  Arg Phe Gly His Thr  Leu Val Asn Pro Leu  Leu Tyr Arg 
    1070                 1075                 1080             


Leu Asp  Glu Asn Phe Gln Pro  Ile Ala Gln Asp His  Leu Pro Leu 
    1085                 1090                 1095             


His Lys  Ala Phe Phe Ser Pro  Phe Arg Ile Val Asn  Glu Gly Gly 
    1100                 1105                 1110             


Ile Asp  Pro Leu Leu Arg Gly  Leu Phe Gly Val Ala  Gly Lys Met 
    1115                 1120                 1125             


Arg Val  Pro Ser Gln Leu Leu  Asn Thr Glu Leu Thr  Glu Arg Leu 
    1130                 1135                 1140             


Phe Ser  Met Ala His Thr Val  Ala Leu Asp Leu Ala  Ala Ile Asn 
    1145                 1150                 1155             


Ile Gln  Arg Gly Arg Asp His  Gly Ile Pro Pro Tyr  His Asp Tyr 
    1160                 1165                 1170             


Arg Val  Tyr Cys Asn Leu Ser  Ala Ala His Thr Phe  Glu Asp Leu 
    1175                 1180                 1185             


Lys Asn  Glu Ile Lys Asn Pro  Glu Ile Arg Glu Lys  Leu Lys Arg 
    1190                 1195                 1200             


Leu Tyr  Gly Ser Thr Leu Asn  Ile Asp Leu Phe Pro  Ala Leu Val 
    1205                 1210                 1215             


Val Glu  Asp Leu Val Pro Gly  Ser Arg Leu Gly Pro  Thr Leu Met 
    1220                 1225                 1230             


Cys Leu  Leu Ser Thr Gln Phe  Lys Arg Leu Arg Asp  Gly Asp Arg 
    1235                 1240                 1245             


Leu Trp  Tyr Glu Asn Pro Gly  Val Phe Ser Pro Ala  Gln Leu Thr 
    1250                 1255                 1260             


Gln Ile  Lys Gln Thr Ser Leu  Ala Arg Ile Leu Cys  Asp Asn Ala 
    1265                 1270                 1275             


Asp Asn  Ile Thr Arg Val Gln  Ser Asp Val Phe Arg  Val Ala Glu 
    1280                 1285                 1290             


Phe Pro  His Gly Tyr Gly Ser  Cys Asp Glu Ile Pro  Arg Val Asp 
    1295                 1300                 1305             


Leu Arg  Val Trp Gln Asp Cys  Cys Glu Asp Cys Arg  Thr Arg Gly 
    1310                 1315                 1320             


Gln Phe  Asn Ala Phe Ser Tyr  His Phe Arg Gly Arg  Arg Ser Leu 
    1325                 1330                 1335             


Glu Phe  Ser Tyr Gln Glu Asp  Lys Pro Thr Lys Lys  Thr Arg Pro 
    1340                 1345                 1350             


Arg Lys  Ile Pro Ser Val Gly  Arg Gln Gly Glu His  Leu Ser Asn 
    1355                 1360                 1365             


Ser Thr  Ser Ala Phe Ser Thr  Arg Ser Asp Ala Ser  Gly Thr Asn 
    1370                 1375                 1380             


Asp Phe  Arg Glu Phe Val Leu  Glu Met Gln Lys Thr  Ile Thr Asp 
    1385                 1390                 1395             


Leu Arg  Thr Gln Ile Lys Lys  Leu Glu Ser Arg Leu  Ser Thr Thr 
    1400                 1405                 1410             


Glu Cys  Val Asp Ala Gly Gly  Glu Ser His Ala Asn  Asn Thr Lys 
    1415                 1420                 1425             


Trp Lys  Lys Asp Ala Cys Thr  Ile Cys Glu Cys Lys  Asp Gly Gln 
    1430                 1435                 1440             


Val Thr  Cys Phe Val Glu Ala  Cys Pro Pro Ala Thr  Cys Ala Val 
    1445                 1450                 1455             


Pro Val  Asn Ile Pro Gly Ala  Cys Cys Pro Val Cys  Leu Gln Lys 
    1460                 1465                 1470             


Arg Ala  Glu Glu Lys Pro 
    1475                 


<210>  4
<211>  3570
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Trp Pro Arg Leu Ala Phe Cys Cys Trp Gly Leu Ala Leu Val Ser 
1               5                   10                  15      


Gly Trp Ala Thr Phe Gln Gln Met Ser Pro Ser Arg Asn Phe Ser Phe 
            20                  25                  30          


Arg Leu Phe Pro Glu Thr Ala Pro Gly Ala Pro Gly Ser Ile Pro Ala 
        35                  40                  45              


Pro Pro Ala Pro Gly Asp Glu Ala Ala Gly Ser Arg Val Glu Arg Leu 
    50                  55                  60                  


Gly Gln Ala Phe Arg Arg Arg Val Arg Leu Leu Arg Glu Leu Ser Glu 
65                  70                  75                  80  


Arg Leu Glu Leu Val Phe Leu Val Asp Asp Ser Ser Ser Val Gly Glu 
                85                  90                  95      


Val Asn Phe Arg Ser Glu Leu Met Phe Val Arg Lys Leu Leu Ser Asp 
            100                 105                 110         


Phe Pro Val Val Pro Thr Ala Thr Arg Val Ala Ile Val Thr Phe Ser 
        115                 120                 125             


Ser Lys Asn Tyr Val Val Pro Arg Val Asp Tyr Ile Ser Thr Arg Arg 
    130                 135                 140                 


Ala Arg Gln His Lys Cys Ala Leu Leu Leu Gln Glu Ile Pro Ala Ile 
145                 150                 155                 160 


Ser Tyr Arg Gly Gly Gly Thr Tyr Thr Lys Gly Ala Phe Gln Gln Ala 
                165                 170                 175     


Ala Gln Ile Leu Leu His Ala Arg Glu Asn Ser Thr Lys Val Val Phe 
            180                 185                 190         


Leu Ile Thr Asp Gly Tyr Ser Asn Gly Gly Asp Pro Arg Pro Ile Ala 
        195                 200                 205             


Ala Ser Leu Arg Asp Ser Gly Val Glu Ile Phe Thr Phe Gly Ile Trp 
    210                 215                 220                 


Gln Gly Asn Ile Arg Glu Leu Asn Asp Met Ala Ser Thr Pro Lys Glu 
225                 230                 235                 240 


Glu His Cys Tyr Leu Leu His Ser Phe Glu Glu Phe Glu Ala Leu Ala 
                245                 250                 255     


Arg Arg Ala Leu His Glu Asp Leu Pro Ser Gly Ser Phe Ile Gln Asp 
            260                 265                 270         


Asp Met Val His Cys Ser Tyr Leu Cys Asp Glu Gly Lys Asp Cys Cys 
        275                 280                 285             


Asp Arg Met Gly Ser Cys Lys Cys Gly Thr His Thr Gly His Phe Glu 
    290                 295                 300                 


Cys Ile Cys Glu Lys Gly Tyr Tyr Gly Lys Gly Leu Gln Tyr Glu Cys 
305                 310                 315                 320 


Thr Ala Cys Pro Ser Gly Thr Tyr Lys Pro Glu Gly Ser Pro Gly Gly 
                325                 330                 335     


Ile Ser Ser Cys Ile Pro Cys Pro Asp Glu Asn His Thr Ser Pro Pro 
            340                 345                 350         


Gly Ser Thr Ser Pro Glu Asp Cys Val Cys Arg Glu Gly Tyr Arg Ala 
        355                 360                 365             


Ser Gly Gln Thr Cys Glu Leu Val His Cys Pro Ala Leu Lys Pro Pro 
    370                 375                 380                 


Glu Asn Gly Tyr Phe Ile Gln Asn Thr Cys Asn Asn His Phe Asn Ala 
385                 390                 395                 400 


Ala Cys Gly Val Arg Cys His Pro Gly Phe Asp Leu Val Gly Ser Ser 
                405                 410                 415     


Ile Ile Leu Cys Leu Pro Asn Gly Leu Trp Ser Gly Ser Glu Ser Tyr 
            420                 425                 430         


Cys Arg Val Arg Thr Cys Pro His Leu Arg Gln Pro Lys His Gly His 
        435                 440                 445             


Ile Ser Cys Ser Thr Arg Glu Met Leu Tyr Lys Thr Thr Cys Leu Val 
    450                 455                 460                 


Ala Cys Asp Glu Gly Tyr Arg Leu Glu Gly Ser Asp Lys Leu Thr Cys 
465                 470                 475                 480 


Gln Gly Asn Ser Gln Trp Asp Gly Pro Glu Pro Arg Cys Val Glu Arg 
                485                 490                 495     


His Cys Ser Thr Phe Gln Met Pro Lys Asp Val Ile Ile Ser Pro His 
            500                 505                 510         


Asn Cys Gly Lys Gln Pro Ala Lys Phe Gly Thr Ile Cys Tyr Val Ser 
        515                 520                 525             


Cys Arg Gln Gly Phe Ile Leu Ser Gly Val Lys Glu Met Leu Arg Cys 
    530                 535                 540                 


Thr Thr Ser Gly Lys Trp Asn Val Gly Val Gln Ala Ala Val Cys Lys 
545                 550                 555                 560 


Asp Val Glu Ala Pro Gln Ile Asn Cys Pro Lys Asp Ile Glu Ala Lys 
                565                 570                 575     


Thr Leu Glu Gln Gln Asp Ser Ala Asn Val Thr Trp Gln Ile Pro Thr 
            580                 585                 590         


Ala Lys Asp Asn Ser Gly Glu Lys Val Ser Val His Val His Pro Ala 
        595                 600                 605             


Phe Thr Pro Pro Tyr Leu Phe Pro Ile Gly Asp Val Ala Ile Val Tyr 
    610                 615                 620                 


Thr Ala Thr Asp Leu Ser Gly Asn Gln Ala Ser Cys Ile Phe His Ile 
625                 630                 635                 640 


Lys Val Ile Asp Ala Glu Pro Pro Val Ile Asp Trp Cys Arg Ser Pro 
                645                 650                 655     


Pro Pro Val Gln Val Ser Glu Lys Val His Ala Ala Ser Trp Asp Glu 
            660                 665                 670         


Pro Gln Phe Ser Asp Asn Ser Gly Ala Glu Leu Val Ile Thr Arg Ser 
        675                 680                 685             


His Thr Gln Gly Asp Leu Phe Pro Gln Gly Glu Thr Ile Val Gln Tyr 
    690                 695                 700                 


Thr Ala Thr Asp Pro Ser Gly Asn Asn Arg Thr Cys Asp Ile His Ile 
705                 710                 715                 720 


Val Ile Lys Gly Ser Pro Cys Glu Ile Pro Phe Thr Pro Val Asn Gly 
                725                 730                 735     


Asp Phe Ile Cys Thr Pro Asp Asn Thr Gly Val Asn Cys Thr Leu Thr 
            740                 745                 750         


Cys Leu Glu Gly Tyr Asp Phe Thr Glu Gly Ser Thr Asp Lys Tyr Tyr 
        755                 760                 765             


Cys Ala Tyr Glu Asp Gly Val Trp Lys Pro Thr Tyr Thr Thr Glu Trp 
    770                 775                 780                 


Pro Asp Cys Ala Lys Lys Arg Phe Ala Asn His Gly Phe Lys Ser Phe 
785                 790                 795                 800 


Glu Met Phe Tyr Lys Ala Ala Arg Cys Asp Asp Thr Asp Leu Met Lys 
                805                 810                 815     


Lys Phe Ser Glu Ala Phe Glu Thr Thr Leu Gly Lys Met Val Pro Ser 
            820                 825                 830         


Phe Cys Ser Asp Ala Glu Asp Ile Asp Cys Arg Leu Glu Glu Asn Leu 
        835                 840                 845             


Thr Lys Lys Tyr Cys Leu Glu Tyr Asn Tyr Asp Tyr Glu Asn Gly Phe 
    850                 855                 860                 


Ala Ile Gly Pro Gly Gly Trp Gly Ala Ala Asn Arg Leu Asp Tyr Ser 
865                 870                 875                 880 


Tyr Asp Asp Phe Leu Asp Thr Val Gln Glu Thr Ala Thr Ser Ile Gly 
                885                 890                 895     


Asn Ala Lys Ser Ser Arg Ile Lys Arg Ser Ala Pro Leu Ser Asp Tyr 
            900                 905                 910         


Lys Ile Lys Leu Ile Phe Asn Ile Thr Ala Ser Val Pro Leu Pro Asp 
        915                 920                 925             


Glu Arg Asn Asp Thr Leu Glu Trp Glu Asn Gln Gln Arg Leu Leu Gln 
    930                 935                 940                 


Thr Leu Glu Thr Ile Thr Asn Lys Leu Lys Arg Thr Leu Asn Lys Asp 
945                 950                 955                 960 


Pro Met Tyr Ser Phe Gln Leu Ala Ser Glu Ile Leu Ile Ala Asp Ser 
                965                 970                 975     


Asn Ser Leu Glu Thr Lys Lys Ala Ser Pro Phe Cys Arg Pro Gly Ser 
            980                 985                 990         


Val Leu Arg Gly Arg Met Cys Val  Asn Cys Pro Leu Gly  Thr Tyr Tyr 
        995                 1000                 1005             


Asn Leu  Glu His Phe Thr Cys  Glu Ser Cys Arg Ile  Gly Ser Tyr 
    1010                 1015                 1020             


Gln Asp  Glu Glu Gly Gln Leu  Glu Cys Lys Leu Cys  Pro Ser Gly 
    1025                 1030                 1035             


Met Tyr  Thr Glu Tyr Ile His  Ser Arg Asn Ile Ser  Asp Cys Lys 
    1040                 1045                 1050             


Ala Gln  Cys Lys Gln Gly Thr  Tyr Ser Tyr Ser Gly  Leu Glu Thr 
    1055                 1060                 1065             


Cys Glu  Ser Cys Pro Leu Gly  Thr Tyr Gln Pro Lys  Phe Gly Ser 
    1070                 1075                 1080             


Arg Ser  Cys Leu Ser Cys Pro  Glu Asn Thr Ser Thr  Val Lys Arg 
    1085                 1090                 1095             


Gly Ala  Val Asn Ile Ser Ala  Cys Gly Val Pro Cys  Pro Glu Gly 
    1100                 1105                 1110             


Lys Phe  Ser Arg Ser Gly Leu  Met Pro Cys His Pro  Cys Pro Arg 
    1115                 1120                 1125             


Asp Tyr  Tyr Gln Pro Asn Ala  Gly Lys Ala Phe Cys  Leu Ala Cys 
    1130                 1135                 1140             


Pro Phe  Tyr Gly Thr Thr Pro  Phe Ala Gly Ser Arg  Ser Ile Thr 
    1145                 1150                 1155             


Glu Cys  Ser Ser Phe Ser Ser  Thr Phe Ser Ala Ala  Glu Glu Ser 
    1160                 1165                 1170             


Val Val  Pro Pro Ala Ser Leu  Gly His Ile Lys Lys  Arg His Glu 
    1175                 1180                 1185             


Ile Ser  Ser Gln Val Phe His  Glu Cys Phe Phe Asn  Pro Cys His 
    1190                 1195                 1200             


Asn Ser  Gly Thr Cys Gln Gln  Leu Gly Arg Gly Tyr  Val Cys Leu 
    1205                 1210                 1215             


Cys Pro  Leu Gly Tyr Thr Gly  Leu Lys Cys Glu Thr  Asp Ile Asp 
    1220                 1225                 1230             


Glu Cys  Ser Pro Leu Pro Cys  Leu Asn Asn Gly Val  Cys Lys Asp 
    1235                 1240                 1245             


Leu Val  Gly Glu Phe Ile Cys  Glu Cys Pro Ser Gly  Tyr Thr Gly 
    1250                 1255                 1260             


Gln Arg  Cys Glu Glu Asn Ile  Asn Glu Cys Ser Ser  Ser Pro Cys 
    1265                 1270                 1275             


Leu Asn  Lys Gly Ile Cys Val  Asp Gly Val Ala Gly  Tyr Arg Cys 
    1280                 1285                 1290             


Thr Cys  Val Lys Gly Phe Val  Gly Leu His Cys Glu  Thr Glu Val 
    1295                 1300                 1305             


Asn Glu  Cys Gln Ser Asn Pro  Cys Leu Asn Asn Ala  Val Cys Glu 
    1310                 1315                 1320             


Asp Gln  Val Gly Gly Phe Leu  Cys Lys Cys Pro Pro  Gly Phe Leu 
    1325                 1330                 1335             


Gly Thr  Arg Cys Gly Lys Asn  Val Asp Glu Cys Leu  Ser Gln Pro 
    1340                 1345                 1350             


Cys Lys  Asn Gly Ala Thr Cys  Lys Asp Gly Ala Asn  Ser Phe Arg 
    1355                 1360                 1365             


Cys Leu  Cys Ala Ala Gly Phe  Thr Gly Ser His Cys  Glu Leu Asn 
    1370                 1375                 1380             


Ile Asn  Glu Cys Gln Ser Asn  Pro Cys Arg Asn Gln  Ala Thr Cys 
    1385                 1390                 1395             


Val Asp  Glu Leu Asn Ser Tyr  Ser Cys Lys Cys Gln  Pro Gly Phe 
    1400                 1405                 1410             


Ser Gly  Lys Arg Cys Glu Thr  Glu Gln Ser Thr Gly  Phe Asn Leu 
    1415                 1420                 1425             


Asp Phe  Glu Val Ser Gly Ile  Tyr Gly Tyr Val Met  Leu Asp Gly 
    1430                 1435                 1440             


Met Leu  Pro Ser Leu His Ala  Leu Thr Cys Thr Phe  Trp Met Lys 
    1445                 1450                 1455             


Ser Ser  Asp Asp Met Asn Tyr  Gly Thr Pro Ile Ser  Tyr Ala Val 
    1460                 1465                 1470             


Asp Asn  Gly Ser Asp Asn Thr  Leu Leu Leu Thr Asp  Tyr Asn Gly 
    1475                 1480                 1485             


Trp Val  Leu Tyr Val Asn Gly  Arg Glu Lys Ile Thr  Asn Cys Pro 
    1490                 1495                 1500             


Ser Val  Asn Asp Gly Arg Trp  His His Ile Ala Ile  Thr Trp Thr 
    1505                 1510                 1515             


Ser Ala  Asn Gly Ile Trp Lys  Val Tyr Ile Asp Gly  Lys Leu Ser 
    1520                 1525                 1530             


Asp Gly  Gly Ala Gly Leu Ser  Val Gly Leu Pro Ile  Pro Gly Gly 
    1535                 1540                 1545             


Gly Ala  Leu Val Leu Gly Gln  Glu Gln Asp Lys Lys  Gly Glu Gly 
    1550                 1555                 1560             


Phe Ser  Pro Ala Glu Ser Phe  Val Gly Ser Ile Ser  Gln Leu Asn 
    1565                 1570                 1575             


Leu Trp  Asp Tyr Val Leu Ser  Pro Gln Gln Val Lys  Ser Leu Ala 
    1580                 1585                 1590             


Thr Ser  Cys Pro Glu Glu Leu  Ser Lys Gly Asn Val  Leu Ala Trp 
    1595                 1600                 1605             


Pro Asp  Phe Leu Ser Gly Ile  Val Gly Lys Val Lys  Ile Asp Ser 
    1610                 1615                 1620             


Lys Ser  Ile Phe Cys Ser Asp  Cys Pro Arg Leu Gly  Gly Ser Val 
    1625                 1630                 1635             


Pro His  Leu Arg Thr Ala Ser  Glu Asp Leu Lys Pro  Gly Ser Lys 
    1640                 1645                 1650             


Val Asn  Leu Phe Cys Asp Pro  Gly Phe Gln Leu Val  Gly Asn Pro 
    1655                 1660                 1665             


Val Gln  Tyr Cys Leu Asn Gln  Gly Gln Trp Thr Gln  Pro Leu Pro 
    1670                 1675                 1680             


His Cys  Glu Arg Ile Ser Cys  Gly Val Pro Pro Pro  Leu Glu Asn 
    1685                 1690                 1695             


Gly Phe  His Ser Ala Asp Asp  Phe Tyr Ala Gly Ser  Thr Val Thr 
    1700                 1705                 1710             


Tyr Gln  Cys Asn Asn Gly Tyr  Tyr Leu Leu Gly Asp  Ser Arg Met 
    1715                 1720                 1725             


Phe Cys  Thr Asp Asn Gly Ser  Trp Asn Gly Val Ser  Pro Ser Cys 
    1730                 1735                 1740             


Leu Asp  Val Asp Glu Cys Ala  Val Gly Ser Asp Cys  Ser Glu His 
    1745                 1750                 1755             


Ala Ser  Cys Leu Asn Val Asp  Gly Ser Tyr Ile Cys  Ser Cys Val 
    1760                 1765                 1770             


Pro Pro  Tyr Thr Gly Asp Gly  Lys Asn Cys Ala Glu  Pro Ile Lys 
    1775                 1780                 1785             


Cys Lys  Ala Pro Gly Asn Pro  Glu Asn Gly His Ser  Ser Gly Glu 
    1790                 1795                 1800             


Ile Tyr  Thr Val Gly Ala Glu  Val Thr Phe Ser Cys  Gln Glu Gly 
    1805                 1810                 1815             


Tyr Gln  Leu Met Gly Val Thr  Lys Ile Thr Cys Leu  Glu Ser Gly 
    1820                 1825                 1830             


Glu Trp  Asn His Leu Ile Pro  Tyr Cys Lys Ala Val  Ser Cys Gly 
    1835                 1840                 1845             


Lys Pro  Ala Ile Pro Glu Asn  Gly Cys Ile Glu Glu  Leu Ala Phe 
    1850                 1855                 1860             


Thr Phe  Gly Ser Lys Val Thr  Tyr Arg Cys Asn Lys  Gly Tyr Thr 
    1865                 1870                 1875             


Leu Ala  Gly Asp Lys Glu Ser  Ser Cys Leu Ala Asn  Ser Ser Trp 
    1880                 1885                 1890             


Ser His  Ser Pro Pro Val Cys  Glu Pro Val Lys Cys  Ser Ser Pro 
    1895                 1900                 1905             


Glu Asn  Ile Asn Asn Gly Lys  Tyr Ile Leu Ser Gly  Leu Thr Tyr 
    1910                 1915                 1920             


Leu Ser  Thr Ala Ser Tyr Ser  Cys Asp Thr Gly Tyr  Ser Leu Gln 
    1925                 1930                 1935             


Gly Pro  Ser Ile Ile Glu Cys  Thr Ala Ser Gly Ile  Trp Asp Arg 
    1940                 1945                 1950             


Ala Pro  Pro Ala Cys His Leu  Val Phe Cys Gly Glu  Pro Pro Ala 
    1955                 1960                 1965             


Ile Lys  Asp Ala Val Ile Thr  Gly Asn Asn Phe Thr  Phe Arg Asn 
    1970                 1975                 1980             


Thr Val  Thr Tyr Thr Cys Lys  Glu Gly Tyr Thr Leu  Ala Gly Leu 
    1985                 1990                 1995             


Asp Thr  Ile Glu Cys Leu Ala  Asp Gly Lys Trp Ser  Arg Ser Asp 
    2000                 2005                 2010             


Gln Gln  Cys Leu Ala Val Ser  Cys Asp Glu Pro Pro  Ile Val Asp 
    2015                 2020                 2025             


His Ala  Ser Pro Glu Thr Ala  His Arg Leu Phe Gly  Asp Ile Ala 
    2030                 2035                 2040             


Phe Tyr  Tyr Cys Ser Asp Gly  Tyr Ser Leu Ala Asp  Asn Ser Gln 
    2045                 2050                 2055             


Leu Leu  Cys Asn Ala Gln Gly  Lys Trp Val Pro Pro  Glu Gly Gln 
    2060                 2065                 2070             


Asp Met  Pro Arg Cys Ile Ala  His Phe Cys Glu Lys  Pro Pro Ser 
    2075                 2080                 2085             


Val Ser  Tyr Ser Ile Leu Glu  Ser Val Ser Lys Ala  Lys Phe Ala 
    2090                 2095                 2100             


Ala Gly  Ser Val Val Ser Phe  Lys Cys Met Glu Gly  Phe Val Leu 
    2105                 2110                 2115             


Asn Thr  Ser Ala Lys Ile Glu  Cys Met Arg Gly Gly  Gln Trp Asn 
    2120                 2125                 2130             


Pro Ser  Pro Met Ser Ile Gln  Cys Ile Pro Val Arg  Cys Gly Glu 
    2135                 2140                 2145             


Pro Pro  Ser Ile Met Asn Gly  Tyr Ala Ser Gly Ser  Asn Tyr Ser 
    2150                 2155                 2160             


Phe Gly  Ala Met Val Ala Tyr  Ser Cys Asn Lys Gly  Phe Tyr Ile 
    2165                 2170                 2175             


Lys Gly  Glu Lys Lys Ser Thr  Cys Glu Ala Thr Gly  Gln Trp Ser 
    2180                 2185                 2190             


Ser Pro  Ile Pro Thr Cys His  Pro Val Ser Cys Gly  Glu Pro Pro 
    2195                 2200                 2205             


Lys Val  Glu Asn Gly Phe Leu  Glu His Thr Thr Gly  Arg Ile Phe 
    2210                 2215                 2220             


Glu Ser  Glu Val Arg Tyr Gln  Cys Asn Pro Gly Tyr  Lys Ser Val 
    2225                 2230                 2235             


Gly Ser  Pro Val Phe Val Cys  Gln Ala Asn Arg His  Trp His Ser 
    2240                 2245                 2250             


Glu Ser  Pro Leu Met Cys Val  Pro Leu Asp Cys Gly  Lys Pro Pro 
    2255                 2260                 2265             


Pro Ile  Gln Asn Gly Phe Met  Lys Gly Glu Asn Phe  Glu Val Gly 
    2270                 2275                 2280             


Ser Lys  Val Gln Phe Phe Cys  Asn Glu Gly Tyr Glu  Leu Val Gly 
    2285                 2290                 2295             


Asp Ser  Ser Trp Thr Cys Gln  Lys Ser Gly Lys Trp  Asn Lys Lys 
    2300                 2305                 2310             


Ser Asn  Pro Lys Cys Met Pro  Ala Lys Cys Pro Glu  Pro Pro Leu 
    2315                 2320                 2325             


Leu Glu  Asn Gln Leu Val Leu  Lys Glu Leu Thr Thr  Glu Val Gly 
    2330                 2335                 2340             


Val Val  Thr Phe Ser Cys Lys  Glu Gly His Val Leu  Gln Gly Pro 
    2345                 2350                 2355             


Ser Val  Leu Lys Cys Leu Pro  Ser Gln Gln Trp Asn  Asp Ser Phe 
    2360                 2365                 2370             


Pro Val  Cys Lys Ile Val Leu  Cys Thr Pro Pro Pro  Leu Ile Ser 
    2375                 2380                 2385             


Phe Gly  Val Pro Ile Pro Ser  Ser Ala Leu His Phe  Gly Ser Thr 
    2390                 2395                 2400             


Val Lys  Tyr Ser Cys Val Gly  Gly Phe Phe Leu Arg  Gly Asn Ser 
    2405                 2410                 2415             


Thr Thr  Leu Cys Gln Pro Asp  Gly Thr Trp Ser Ser  Pro Leu Pro 
    2420                 2425                 2430             


Glu Cys  Val Pro Val Glu Cys  Pro Gln Pro Glu Glu  Ile Pro Asn 
    2435                 2440                 2445             


Gly Ile  Ile Asp Val Gln Gly  Leu Ala Tyr Leu Ser  Thr Ala Leu 
    2450                 2455                 2460             


Tyr Thr  Cys Lys Pro Gly Phe  Glu Leu Val Gly Asn  Thr Thr Thr 
    2465                 2470                 2475             


Leu Cys  Gly Glu Asn Gly His  Trp Leu Gly Gly Lys  Pro Thr Cys 
    2480                 2485                 2490             


Lys Ala  Ile Glu Cys Leu Lys  Pro Lys Glu Ile Leu  Asn Gly Lys 
    2495                 2500                 2505             


Phe Ser  Tyr Thr Asp Leu His  Tyr Gly Gln Thr Val  Thr Tyr Ser 
    2510                 2515                 2520             


Cys Asn  Arg Gly Phe Arg Leu  Glu Gly Pro Ser Ala  Leu Thr Cys 
    2525                 2530                 2535             


Leu Glu  Thr Gly Asp Trp Asp  Val Asp Ala Pro Ser  Cys Asn Ala 
    2540                 2545                 2550             


Ile His  Cys Asp Ser Pro Gln  Pro Ile Glu Asn Gly  Phe Val Glu 
    2555                 2560                 2565             


Gly Ala  Asp Tyr Ser Tyr Gly  Ala Ile Ile Ile Tyr  Ser Cys Phe 
    2570                 2575                 2580             


Pro Gly  Phe Gln Val Ala Gly  His Ala Met Gln Thr  Cys Glu Glu 
    2585                 2590                 2595             


Ser Gly  Trp Ser Ser Ser Ile  Pro Thr Cys Met Pro  Ile Asp Cys 
    2600                 2605                 2610             


Gly Leu  Pro Pro His Ile Asp  Phe Gly Asp Cys Thr  Lys Leu Lys 
    2615                 2620                 2625             


Asp Asp  Gln Gly Tyr Phe Glu  Gln Glu Asp Asp Met  Met Glu Val 
    2630                 2635                 2640             


Pro Tyr  Val Thr Pro His Pro  Pro Tyr His Leu Gly  Ala Val Ala 
    2645                 2650                 2655             


Lys Thr  Trp Glu Asn Thr Lys  Glu Ser Pro Ala Thr  His Ser Ser 
    2660                 2665                 2670             


Asn Phe  Leu Tyr Gly Thr Met  Val Ser Tyr Thr Cys  Asn Pro Gly 
    2675                 2680                 2685             


Tyr Glu  Leu Leu Gly Asn Pro  Val Leu Ile Cys Gln  Glu Asp Gly 
    2690                 2695                 2700             


Thr Trp  Asn Gly Ser Ala Pro  Ser Cys Ile Ser Ile  Glu Cys Asp 
    2705                 2710                 2715             


Leu Pro  Thr Ala Pro Glu Asn  Gly Phe Leu Arg Phe  Thr Glu Thr 
    2720                 2725                 2730             


Ser Met  Gly Ser Ala Val Gln  Tyr Ser Cys Lys Pro  Gly His Ile 
    2735                 2740                 2745             


Leu Ala  Gly Ser Asp Leu Arg  Leu Cys Leu Glu Asn  Arg Lys Trp 
    2750                 2755                 2760             


Ser Gly  Ala Ser Pro Arg Cys  Glu Ala Ile Ser Cys  Lys Lys Pro 
    2765                 2770                 2775             


Asn Pro  Val Met Asn Gly Ser  Ile Lys Gly Ser Asn  Tyr Thr Tyr 
    2780                 2785                 2790             


Leu Ser  Thr Leu Tyr Tyr Glu  Cys Asp Pro Gly Tyr  Val Leu Asn 
    2795                 2800                 2805             


Gly Thr  Glu Arg Arg Thr Cys  Gln Asp Asp Lys Asn  Trp Asp Glu 
    2810                 2815                 2820             


Asp Glu  Pro Ile Cys Ile Pro  Val Asp Cys Ser Ser  Pro Pro Val 
    2825                 2830                 2835             


Ser Ala  Asn Gly Gln Val Arg  Gly Asp Glu Tyr Thr  Phe Gln Lys 
    2840                 2845                 2850             


Glu Ile  Glu Tyr Thr Cys Asn  Glu Gly Phe Leu Leu  Glu Gly Ala 
    2855                 2860                 2865             


Arg Ser  Arg Val Cys Leu Ala  Asn Gly Ser Trp Ser  Gly Ala Thr 
    2870                 2875                 2880             


Pro Asp  Cys Val Pro Val Arg  Cys Ala Thr Pro Pro  Gln Leu Ala 
    2885                 2890                 2895             


Asn Gly  Val Thr Glu Gly Leu  Asp Tyr Gly Phe Met  Lys Glu Val 
    2900                 2905                 2910             


Thr Phe  His Cys His Glu Gly  Tyr Ile Leu His Gly  Ala Pro Lys 
    2915                 2920                 2925             


Leu Thr  Cys Gln Ser Asp Gly  Asn Trp Asp Ala Glu  Ile Pro Leu 
    2930                 2935                 2940             


Cys Lys  Pro Val Asn Cys Gly  Pro Pro Glu Asp Leu  Ala His Gly 
    2945                 2950                 2955             


Phe Pro  Asn Gly Phe Ser Phe  Ile His Gly Gly His  Ile Gln Tyr 
    2960                 2965                 2970             


Gln Cys  Phe Pro Gly Tyr Lys  Leu His Gly Asn Ser  Ser Arg Arg 
    2975                 2980                 2985             


Cys Leu  Ser Asn Gly Ser Trp  Ser Gly Ser Ser Pro  Ser Cys Leu 
    2990                 2995                 3000             


Pro Cys  Arg Cys Ser Thr Pro  Val Ile Glu Tyr Gly  Thr Val Asn 
    3005                 3010                 3015             


Gly Thr  Asp Phe Asp Cys Gly  Lys Ala Ala Arg Ile  Gln Cys Phe 
    3020                 3025                 3030             


Lys Gly  Phe Lys Leu Leu Gly  Leu Ser Glu Ile Thr  Cys Glu Ala 
    3035                 3040                 3045             


Asp Gly  Gln Trp Ser Ser Gly  Phe Pro His Cys Glu  His Thr Ser 
    3050                 3055                 3060             


Cys Gly  Ser Leu Pro Met Ile  Pro Asn Ala Phe Ile  Ser Glu Thr 
    3065                 3070                 3075             


Ser Ser  Trp Lys Glu Asn Val  Ile Thr Tyr Ser Cys  Arg Ser Gly 
    3080                 3085                 3090             


Tyr Val  Ile Gln Gly Ser Ser  Asp Leu Ile Cys Thr  Glu Lys Gly 
    3095                 3100                 3105             


Val Trp  Ser Gln Pro Tyr Pro  Val Cys Glu Pro Leu  Ser Cys Gly 
    3110                 3115                 3120             


Ser Pro  Pro Ser Val Ala Asn  Ala Val Ala Thr Gly  Glu Ala His 
    3125                 3130                 3135             


Thr Tyr  Glu Ser Glu Val Lys  Leu Arg Cys Leu Glu  Gly Tyr Thr 
    3140                 3145                 3150             


Met Asp  Thr Asp Thr Asp Thr  Phe Thr Cys Gln Lys  Asp Gly Arg 
    3155                 3160                 3165             


Trp Phe  Pro Glu Arg Ile Ser  Cys Ser Pro Lys Lys  Cys Pro Leu 
    3170                 3175                 3180             


Pro Glu  Asn Ile Thr His Ile  Leu Val His Gly Asp  Asp Phe Ser 
    3185                 3190                 3195             


Val Asn  Arg Gln Val Ser Val  Ser Cys Ala Glu Gly  Tyr Thr Phe 
    3200                 3205                 3210             


Glu Gly  Val Asn Ile Ser Val  Cys Gln Leu Asp Gly  Thr Trp Glu 
    3215                 3220                 3225             


Pro Pro  Phe Ser Asp Glu Ser  Cys Ser Pro Val Ser  Cys Gly Lys 
    3230                 3235                 3240             


Pro Glu  Ser Pro Glu His Gly  Phe Val Val Gly Ser  Lys Tyr Thr 
    3245                 3250                 3255             


Phe Glu  Ser Thr Ile Ile Tyr  Gln Cys Glu Pro Gly  Tyr Glu Leu 
    3260                 3265                 3270             


Glu Gly  Asn Arg Glu Arg Val  Cys Gln Glu Asn Arg  Gln Trp Ser 
    3275                 3280                 3285             


Gly Gly  Val Ala Ile Cys Lys  Glu Thr Arg Cys Glu  Thr Pro Leu 
    3290                 3295                 3300             


Glu Phe  Leu Asn Gly Lys Ala  Asp Ile Glu Asn Arg  Thr Thr Gly 
    3305                 3310                 3315             


Pro Asn  Val Val Tyr Ser Cys  Asn Arg Gly Tyr Ser  Leu Glu Gly 
    3320                 3325                 3330             


Pro Ser  Glu Ala His Cys Thr  Glu Asn Gly Thr Trp  Ser His Pro 
    3335                 3340                 3345             


Val Pro  Leu Cys Lys Pro Asn  Pro Cys Pro Val Pro  Phe Val Ile 
    3350                 3355                 3360             


Pro Glu  Asn Ala Leu Leu Ser  Glu Lys Glu Phe Tyr  Val Asp Gln 
    3365                 3370                 3375             


Asn Val  Ser Ile Lys Cys Arg  Glu Gly Phe Leu Leu  Gln Gly His 
    3380                 3385                 3390             


Gly Ile  Ile Thr Cys Asn Pro  Asp Glu Thr Trp Thr  Gln Thr Ser 
    3395                 3400                 3405             


Ala Lys  Cys Glu Lys Ile Ser  Cys Gly Pro Pro Ala  His Val Glu 
    3410                 3415                 3420             


Asn Ala  Ile Ala Arg Gly Val  His Tyr Gln Tyr Gly  Asp Met Ile 
    3425                 3430                 3435             


Thr Tyr  Ser Cys Tyr Ser Gly  Tyr Met Leu Glu Gly  Phe Leu Arg 
    3440                 3445                 3450             


Ser Val  Cys Leu Glu Asn Gly  Thr Trp Thr Ser Pro  Pro Ile Cys 
    3455                 3460                 3465             


Arg Ala  Val Cys Arg Phe Pro  Cys Gln Asn Gly Gly  Ile Cys Gln 
    3470                 3475                 3480             


Arg Pro  Asn Ala Cys Ser Cys  Pro Glu Gly Trp Met  Gly Arg Leu 
    3485                 3490                 3495             


Cys Glu  Glu Pro Ile Cys Ile  Leu Pro Cys Leu Asn  Gly Gly Arg 
    3500                 3505                 3510             


Cys Val  Ala Pro Tyr Gln Cys  Asp Cys Pro Pro Gly  Trp Thr Gly 
    3515                 3520                 3525             


Ser Arg  Cys His Thr Ala Val  Cys Gln Ser Pro Cys  Leu Asn Gly 
    3530                 3535                 3540             


Gly Lys  Cys Val Arg Pro Asn  Arg Cys His Cys Leu  Ser Ser Trp 
    3545                 3550                 3555             


Thr Gly  His Asn Cys Ser Arg  Lys Arg Arg Thr Gly  
    3560                 3565                 3570 


<210>  5
<211>  1172
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Val Trp Arg Leu Val Leu Leu Ala Leu Trp Val Trp Pro Ser Thr 
1               5                   10                  15      


Gln Ala Gly His Gln Asp Lys Asp Thr Thr Phe Asp Leu Phe Ser Ile 
            20                  25                  30          


Ser Asn Ile Asn Arg Lys Thr Ile Gly Ala Lys Gln Phe Arg Gly Pro 
        35                  40                  45              


Asp Pro Gly Val Pro Ala Tyr Arg Phe Val Arg Phe Asp Tyr Ile Pro 
    50                  55                  60                  


Pro Val Asn Ala Asp Asp Leu Ser Lys Ile Thr Lys Ile Met Arg Gln 
65                  70                  75                  80  


Lys Glu Gly Phe Phe Leu Thr Ala Gln Leu Lys Gln Asp Gly Lys Ser 
                85                  90                  95      


Arg Gly Thr Leu Leu Ala Leu Glu Gly Pro Gly Leu Ser Gln Arg Gln 
            100                 105                 110         


Phe Glu Ile Val Ser Asn Gly Pro Ala Asp Thr Leu Asp Leu Thr Tyr 
        115                 120                 125             


Trp Ile Asp Gly Thr Arg His Val Val Ser Leu Glu Asp Val Gly Leu 
    130                 135                 140                 


Ala Asp Ser Gln Trp Lys Asn Val Thr Val Gln Val Ala Gly Glu Thr 
145                 150                 155                 160 


Tyr Ser Leu His Val Gly Cys Asp Leu Ile Asp Ser Phe Ala Leu Asp 
                165                 170                 175     


Glu Pro Phe Tyr Glu His Leu Gln Ala Glu Lys Ser Arg Met Tyr Val 
            180                 185                 190         


Ala Lys Gly Ser Ala Arg Glu Ser His Phe Arg Gly Leu Leu Gln Asn 
        195                 200                 205             


Val His Leu Val Phe Glu Asn Ser Val Glu Asp Ile Leu Ser Lys Lys 
    210                 215                 220                 


Gly Cys Gln Gln Gly Gln Gly Ala Glu Ile Asn Ala Ile Ser Glu Asn 
225                 230                 235                 240 


Thr Glu Thr Leu Arg Leu Gly Pro His Val Thr Thr Glu Tyr Val Gly 
                245                 250                 255     


Pro Ser Ser Glu Arg Arg Pro Glu Val Cys Glu Arg Ser Cys Glu Glu 
            260                 265                 270         


Leu Gly Asn Met Val Gln Glu Leu Ser Gly Leu His Val Leu Val Asn 
        275                 280                 285             


Gln Leu Ser Glu Asn Leu Lys Arg Val Ser Asn Asp Asn Gln Phe Leu 
    290                 295                 300                 


Trp Glu Leu Ile Gly Gly Pro Pro Lys Thr Arg Asn Met Ser Ala Cys 
305                 310                 315                 320 


Trp Gln Asp Gly Arg Phe Phe Ala Glu Asn Glu Thr Trp Val Val Asp 
                325                 330                 335     


Ser Cys Thr Thr Cys Thr Cys Lys Lys Phe Lys Thr Ile Cys His Gln 
            340                 345                 350         


Ile Thr Cys Pro Pro Ala Thr Cys Ala Ser Pro Ser Phe Val Glu Gly 
        355                 360                 365             


Glu Cys Cys Pro Ser Cys Leu His Ser Val Asp Gly Glu Glu Gly Trp 
    370                 375                 380                 


Ser Pro Trp Ala Glu Trp Thr Gln Cys Ser Val Thr Cys Gly Ser Gly 
385                 390                 395                 400 


Thr Gln Gln Arg Gly Arg Ser Cys Asp Val Thr Ser Asn Thr Cys Leu 
                405                 410                 415     


Gly Pro Ser Ile Gln Thr Arg Ala Cys Ser Leu Ser Lys Cys Asp Thr 
            420                 425                 430         


Arg Ile Arg Gln Asp Gly Gly Trp Ser His Trp Ser Pro Trp Ser Ser 
        435                 440                 445             


Cys Ser Val Thr Cys Gly Val Gly Asn Ile Thr Arg Ile Arg Leu Cys 
    450                 455                 460                 


Asn Ser Pro Val Pro Gln Met Gly Gly Lys Asn Cys Lys Gly Ser Gly 
465                 470                 475                 480 


Arg Glu Thr Lys Ala Cys Gln Gly Ala Pro Cys Pro Ile Asp Gly Arg 
                485                 490                 495     


Trp Ser Pro Trp Ser Pro Trp Ser Ala Cys Thr Val Thr Cys Ala Gly 
            500                 505                 510         


Gly Ile Arg Glu Arg Thr Arg Val Cys Asn Ser Pro Glu Pro Gln Tyr 
        515                 520                 525             


Gly Gly Lys Ala Cys Val Gly Asp Val Gln Glu Arg Gln Met Cys Asn 
    530                 535                 540                 


Lys Arg Ser Cys Pro Val Asp Gly Cys Leu Ser Asn Pro Cys Phe Pro 
545                 550                 555                 560 


Gly Ala Gln Cys Ser Ser Phe Pro Asp Gly Ser Trp Ser Cys Gly Ser 
                565                 570                 575     


Cys Pro Val Gly Phe Leu Gly Asn Gly Thr His Cys Glu Asp Leu Asp 
            580                 585                 590         


Glu Cys Ala Leu Val Pro Asp Ile Cys Phe Ser Thr Ser Lys Val Pro 
        595                 600                 605             


Arg Cys Val Asn Thr Gln Pro Gly Phe His Cys Leu Pro Cys Pro Pro 
    610                 615                 620                 


Arg Tyr Arg Gly Asn Gln Pro Val Gly Val Gly Leu Glu Ala Ala Lys 
625                 630                 635                 640 


Thr Glu Lys Gln Val Cys Glu Pro Glu Asn Pro Cys Lys Asp Lys Thr 
                645                 650                 655     


His Asn Cys His Lys His Ala Glu Cys Ile Tyr Leu Gly His Phe Ser 
            660                 665                 670         


Asp Pro Met Tyr Lys Cys Glu Cys Gln Thr Gly Tyr Ala Gly Asp Gly 
        675                 680                 685             


Leu Ile Cys Gly Glu Asp Ser Asp Leu Asp Gly Trp Pro Asn Leu Asn 
    690                 695                 700                 


Leu Val Cys Ala Thr Asn Ala Thr Tyr His Cys Ile Lys Asp Asn Cys 
705                 710                 715                 720 


Pro His Leu Pro Asn Ser Gly Gln Glu Asp Phe Asp Lys Asp Gly Ile 
                725                 730                 735     


Gly Asp Ala Cys Asp Asp Asp Asp Asp Asn Asp Gly Val Thr Asp Glu 
            740                 745                 750         


Lys Asp Asn Cys Gln Leu Leu Phe Asn Pro Arg Gln Ala Asp Tyr Asp 
        755                 760                 765             


Lys Asp Glu Val Gly Asp Arg Cys Asp Asn Cys Pro Tyr Val His Asn 
    770                 775                 780                 


Pro Ala Gln Ile Asp Thr Asp Asn Asn Gly Glu Gly Asp Ala Cys Ser 
785                 790                 795                 800 


Val Asp Ile Asp Gly Asp Asp Val Phe Asn Glu Arg Asp Asn Cys Pro 
                805                 810                 815     


Tyr Val Tyr Asn Thr Asp Gln Arg Asp Thr Asp Gly Asp Gly Val Gly 
            820                 825                 830         


Asp His Cys Asp Asn Cys Pro Leu Val His Asn Pro Asp Gln Thr Asp 
        835                 840                 845             


Val Asp Asn Asp Leu Val Gly Asp Gln Cys Asp Asn Asn Glu Asp Ile 
    850                 855                 860                 


Asp Asp Asp Gly His Gln Asn Asn Gln Asp Asn Cys Pro Tyr Ile Ser 
865                 870                 875                 880 


Asn Ala Asn Gln Ala Asp His Asp Arg Asp Gly Gln Gly Asp Ala Cys 
                885                 890                 895     


Asp Pro Asp Asp Asp Asn Asp Gly Val Pro Asp Asp Arg Asp Asn Cys 
            900                 905                 910         


Arg Leu Val Phe Asn Pro Asp Gln Glu Asp Leu Asp Gly Asp Gly Arg 
        915                 920                 925             


Gly Asp Ile Cys Lys Asp Asp Phe Asp Asn Asp Asn Ile Pro Asp Ile 
    930                 935                 940                 


Asp Asp Val Cys Pro Glu Asn Asn Ala Ile Ser Glu Thr Asp Phe Arg 
945                 950                 955                 960 


Asn Phe Gln Met Val Pro Leu Asp Pro Lys Gly Thr Thr Gln Ile Asp 
                965                 970                 975     


Pro Asn Trp Val Ile Arg His Gln Gly Lys Glu Leu Val Gln Thr Ala 
            980                 985                 990         


Asn Ser Asp Pro Gly Ile Ala Val  Gly Phe Asp Glu Phe  Gly Ser Val 
        995                 1000                 1005             


Asp Phe  Ser Gly Thr Phe Tyr  Val Asn Thr Asp Arg  Asp Asp Asp 
    1010                 1015                 1020             


Tyr Ala  Gly Phe Val Phe Gly  Tyr Gln Ser Ser Ser  Arg Phe Tyr 
    1025                 1030                 1035             


Val Val  Met Trp Lys Gln Val  Thr Gln Thr Tyr Trp  Glu Asp Gln 
    1040                 1045                 1050             


Pro Thr  Arg Ala Tyr Gly Tyr  Ser Gly Val Ser Leu  Lys Val Val 
    1055                 1060                 1065             


Asn Ser  Thr Thr Gly Thr Gly  Glu His Leu Arg Asn  Ala Leu Trp 
    1070                 1075                 1080             


His Thr  Gly Asn Thr Pro Gly  Gln Val Arg Thr Leu  Trp His Asp 
    1085                 1090                 1095             


Pro Arg  Asn Ile Gly Trp Lys  Asp Tyr Thr Ala Tyr  Arg Trp His 
    1100                 1105                 1110             


Leu Thr  His Arg Pro Lys Thr  Gly Tyr Ile Arg Val  Leu Val His 
    1115                 1120                 1125             


Glu Gly  Lys Gln Val Met Ala  Asp Ser Gly Pro Ile  Tyr Asp Gln 
    1130                 1135                 1140             


Thr Tyr  Ala Gly Gly Arg Leu  Gly Leu Phe Val Phe  Ser Gln Glu 
    1145                 1150                 1155             


Met Val  Tyr Phe Ser Asp Leu  Lys Tyr Glu Cys Arg  Asp Ile 
    1160                 1165                 1170         


<210>  6
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Asp Gly Trp Arg Arg Met Pro Arg Trp Gly Leu Leu Leu Leu Leu 
1               5                   10                  15      


Trp Gly Ser Cys Thr Phe Gly Leu Pro Thr Asp Thr Thr Thr Phe Lys 
            20                  25                  30          


Arg Ile Phe Leu Lys Arg Met Pro Ser Ile Arg Glu Ser Leu Lys Glu 
        35                  40                  45              


Arg Gly Val Asp Met Ala Arg Leu Gly Pro Glu Trp Ser Gln Pro Met 
    50                  55                  60                  


Lys Arg Leu Thr Leu Gly Asn Thr Thr Ser Ser Val Ile Leu Thr Asn 
65                  70                  75                  80  


Tyr Met Asp Thr Gln Tyr Tyr Gly Glu Ile Gly Ile Gly Thr Pro Pro 
                85                  90                  95      


Gln Thr Phe Lys Val Val Phe Asp Thr Gly Ser Ser Asn Val Trp Val 
            100                 105                 110         


Pro Ser Ser Lys Cys Ser Arg Leu Tyr Thr Ala Cys Val Tyr His Lys 
        115                 120                 125             


Leu Phe Asp Ala Ser Asp Ser Ser Ser Tyr Lys His Asn Gly Thr Glu 
    130                 135                 140                 


Leu Thr Leu Arg Tyr Ser Thr Gly Thr Val Ser Gly Phe Leu Ser Gln 
145                 150                 155                 160 


Asp Ile Ile Thr Val Gly Gly Ile Thr Val Thr Gln Met Phe Gly Glu 
                165                 170                 175     


Val Thr Glu Met Pro Ala Leu Pro Phe Met Leu Ala Glu Phe Asp Gly 
            180                 185                 190         


Val Val Gly Met Gly Phe Ile Glu Gln Ala Ile Gly Arg Val Thr Pro 
        195                 200                 205             


Ile Phe Asp Asn Ile Ile Ser Gln Gly Val Leu Lys Glu Asp Val Phe 
    210                 215                 220                 


Ser Phe Tyr Tyr Asn Arg Asp Ser Glu Asn Ser Gln Ser Leu Gly Gly 
225                 230                 235                 240 


Gln Ile Val Leu Gly Gly Ser Asp Pro Gln His Tyr Glu Gly Asn Phe 
                245                 250                 255     


His Tyr Ile Asn Leu Ile Lys Thr Gly Val Trp Gln Ile Gln Met Lys 
            260                 265                 270         


Gly Val Ser Val Gly Ser Ser Thr Leu Leu Cys Glu Asp Gly Cys Leu 
        275                 280                 285             


Ala Leu Val Asp Thr Gly Ala Ser Tyr Ile Ser Gly Ser Thr Ser Ser 
    290                 295                 300                 


Ile Glu Lys Leu Met Glu Ala Leu Gly Ala Lys Lys Arg Leu Phe Asp 
305                 310                 315                 320 


Tyr Val Val Lys Cys Asn Glu Gly Pro Thr Leu Pro Asp Ile Ser Phe 
                325                 330                 335     


His Leu Gly Gly Lys Glu Tyr Thr Leu Thr Ser Ala Asp Tyr Val Phe 
            340                 345                 350         


Gln Glu Ser Tyr Ser Ser Lys Lys Leu Cys Thr Leu Ala Ile His Ala 
        355                 360                 365             


Met Asp Ile Pro Pro Pro Thr Gly Pro Thr Trp Ala Leu Gly Ala Thr 
    370                 375                 380                 


Phe Ile Arg Lys Phe Tyr Thr Glu Phe Asp Arg Arg Asn Asn Arg Ile 
385                 390                 395                 400 


Gly Phe Ala Leu Ala Arg 
                405     


