                         SEQUENCE LISTING

<110>  Genome Research Limited
 
<120>  NOVEL TRYPANOSOMAL VACCINE

<130>  WEL-C-P2899PCT

<150>  2016270.7
<151>  2020-10-14

<160>  62    

<170>  PatentIn version 3.5

<210>  1
<211>  641
<212>  PRT
<213>  Trypanosoma congolense

<400>  1

Ala Val Ala His Val Lys Arg Asn Arg Arg Val Glu Thr Val Ala Gly 
1               5                   10                  15      


Ala Tyr Gly Leu Thr Gly Met Val Asp Gly Val Pro Pro Asp Ser Arg 
            20                  25                  30          


Leu Ser Ser Pro Met Ala Ile Cys Arg Gly Arg Thr Ala Asp Glu Ile 
        35                  40                  45              


Leu Val Gly Thr Ala Ser Gly Leu Arg Thr Tyr Ser Arg Ser Ser Gly 
    50                  55                  60                  


Glu Leu Gly Thr Leu Phe Thr Ser Ser Val Lys Val Val Gly Gly Ser 
65                  70                  75                  80  


Thr Gly Gly Ser Ala Tyr Gly Asn Pro Arg Ser Cys Val His Arg Gly 
                85                  90                  95      


Ile Asp Asn Ser Ser Val Ile Tyr Phe Val Asp Gly Gln Lys Asp Val 
            100                 105                 110         


Lys Tyr Tyr Lys Asn Asn Glu Val Leu Ser Lys Asp Thr Val Ala Asn 
        115                 120                 125             


Ala Ser Leu Thr Ala Met Thr Ile Phe Gly Gly Ser Leu Tyr Met Thr 
    130                 135                 140                 


Asp Gln Ile Asn Lys Ala Leu Val Thr Cys Lys Leu Ser Ala Asp Gly 
145                 150                 155                 160 


Ala Pro His Asp Cys Leu Ser Lys Lys Lys Leu Asn Asp Thr Cys Gly 
                165                 170                 175     


Phe Asn Thr Phe Thr Gly Ile Thr Ser Thr Ala Lys Gly Ile Phe Ile 
            180                 185                 190         


Ala Gly Gln Gly Ser Thr Thr Pro Gly Asn Ile Cys Trp Ile Gly Leu 
        195                 200                 205             


Asp Asp Thr Thr Val Thr Lys Leu Gly Gln Gly Glu Tyr Val Asp Val 
    210                 215                 220                 


Ser Ser Thr Ser Ser Gly Asp Leu Tyr Ala Val Ser Lys Thr Gln Ile 
225                 230                 235                 240 


Phe His Leu Glu Pro Ala Gly Ser Ala Pro Gln Leu Lys Thr Val Ala 
                245                 250                 255     


Gly Val Lys Gly Thr Pro Cys Leu Pro Thr Pro Asp Gly Glu Asp Ile 
            260                 265                 270         


Arg Phe Cys Glu Leu Asn Lys Ile Leu Ala Ile Ala Asp His Glu Leu 
        275                 280                 285             


Tyr Val Thr Ser Glu Arg Ser His Leu Leu Arg Ala Val Ile Leu Pro 
    290                 295                 300                 


Pro Val Arg Val Gln Ala Val Phe Ser Gly Arg Pro Val Pro Val Gly 
305                 310                 315                 320 


Tyr Pro Glu Gly Asp Thr Leu Asp Trp Ile Val Glu Asn Leu Val Lys 
                325                 330                 335     


Asp Val Asn Glu Ala Leu Gln Thr Thr Glu Ser Leu Ile Asp Pro Ser 
            340                 345                 350         


Thr Val Tyr Val Asp Pro Asp Thr Trp Thr Thr Arg Phe Val Ala Leu 
        355                 360                 365             


Val Gln Gln Ser Asp Phe Asp Asp Ala Ala Thr Glu Arg Ala Leu Gly 
    370                 375                 380                 


Glu Gly Asn Tyr Thr Tyr Ile Thr Ala Ala Leu Asp Glu Tyr Tyr Asn 
385                 390                 395                 400 


Glu Thr Asp Gln Ala Val Tyr Met Asp Ser Val Met Val Pro Tyr Cys 
                405                 410                 415     


Ser Glu Ala Ala Leu Asp Ala Ile Arg Arg Arg Ile Ala Glu Glu Ala 
            420                 425                 430         


Arg Arg Val Leu Asp Phe Pro Leu Ile Tyr Ala Asp Met Pro Val Glu 
        435                 440                 445             


Leu Glu Gly Ser Gly Val Glu Asn Val Thr Met Val Lys Leu Leu Met 
    450                 455                 460                 


Pro Ala Ser Phe Asn Asn Glu Thr Val Ser Glu Leu Leu Glu Ala Ala 
465                 470                 475                 480 


Asp Leu Thr Gly Phe Ala His Ser Ala Ile Lys Glu Met Arg Gly Gly 
                485                 490                 495     


Glu Thr Arg Val Ser Val Val Leu Pro Asn Pro Pro Phe Asn Phe Ser 
            500                 505                 510         


Gly Val Thr Pro Asp Val Asp Gln Asp Ile Arg Trp Tyr Val His Gly 
        515                 520                 525             


Asn Val Met Lys Gln Leu Asp Ile Cys Glu Lys Leu Asn Ala Lys Gly 
    530                 535                 540                 


Ala Ala Pro Ala Pro Glu Pro Val Glu Asp Gly Asn Glu Ser Gly Gly 
545                 550                 555                 560 


Gly Val Val Tyr Thr Gly Glu Phe Cys Gln Ser Ser Ile Thr Asn Arg 
                565                 570                 575     


Thr Glu Thr Gln Asn Leu Lys Pro Pro Tyr Asp Gln Lys Asn Thr Tyr 
            580                 585                 590         


Glu Ile Phe Leu Pro Asn Lys Tyr Asp Phe Asn Ala Ser Trp Cys Val 
        595                 600                 605             


Asp Ile Val Asp Trp Arg Glu Leu Asn Asp Trp Leu Ser Asn Val Thr 
    610                 615                 620                 


Ala Gly Ser His Ile Glu Asp Ala Ser Trp Cys Gly Gln Gly Cys Ile 
625                 630                 635                 640 


Ile 
    


<210>  2
<211>  711
<212>  PRT
<213>  Trypanosoma congolense

<400>  2

Met Arg Thr Gly Arg Ala Leu Gln Val Leu Leu His Ala Thr Ile Ile 
1               5                   10                  15      


Ser Leu Gly Leu Val Glu Cys Ala Val Ala His Val Lys Arg Asn Arg 
            20                  25                  30          


Arg Val Glu Thr Val Ala Gly Ala Tyr Gly Leu Thr Gly Met Val Asp 
        35                  40                  45              


Gly Val Pro Pro Asp Ser Arg Leu Ser Ser Pro Met Ala Ile Cys Arg 
    50                  55                  60                  


Gly Arg Thr Ala Asp Glu Ile Leu Val Gly Thr Ala Ser Gly Leu Arg 
65                  70                  75                  80  


Thr Tyr Ser Arg Ser Ser Gly Glu Leu Gly Thr Leu Phe Thr Ser Ser 
                85                  90                  95      


Val Lys Val Val Gly Gly Ser Thr Gly Gly Ser Ala Tyr Gly Asn Pro 
            100                 105                 110         


Arg Ser Cys Val His Arg Gly Ile Asp Asn Ser Ser Val Ile Tyr Phe 
        115                 120                 125             


Val Asp Gly Gln Lys Asp Val Lys Tyr Tyr Lys Asn Asn Glu Val Leu 
    130                 135                 140                 


Ser Lys Asp Thr Val Ala Asn Ala Ser Leu Thr Ala Met Thr Ile Phe 
145                 150                 155                 160 


Gly Gly Ser Leu Tyr Met Thr Asp Gln Ile Asn Lys Ala Leu Val Thr 
                165                 170                 175     


Cys Lys Leu Ser Ala Asp Gly Ala Pro His Asp Cys Leu Ser Lys Lys 
            180                 185                 190         


Lys Leu Asn Asp Thr Cys Gly Phe Asn Thr Phe Thr Gly Ile Thr Ser 
        195                 200                 205             


Thr Ala Lys Gly Ile Phe Ile Ala Gly Gln Gly Ser Thr Thr Pro Gly 
    210                 215                 220                 


Asn Ile Cys Trp Ile Gly Leu Asp Asp Thr Thr Val Thr Lys Leu Gly 
225                 230                 235                 240 


Gln Gly Glu Tyr Val Asp Val Ser Ser Thr Ser Ser Gly Asp Leu Tyr 
                245                 250                 255     


Ala Val Ser Lys Thr Gln Ile Phe His Leu Glu Pro Ala Gly Ser Ala 
            260                 265                 270         


Pro Gln Leu Lys Thr Val Ala Gly Val Lys Gly Thr Pro Cys Leu Pro 
        275                 280                 285             


Thr Pro Asp Gly Glu Asp Ile Arg Phe Cys Glu Leu Asn Lys Ile Leu 
    290                 295                 300                 


Ala Ile Ala Asp His Glu Leu Tyr Val Thr Ser Glu Arg Ser His Leu 
305                 310                 315                 320 


Leu Arg Ala Val Ile Leu Pro Pro Val Arg Val Gln Ala Val Phe Ser 
                325                 330                 335     


Gly Arg Pro Val Pro Val Gly Tyr Pro Glu Gly Asp Thr Leu Asp Trp 
            340                 345                 350         


Ile Val Glu Asn Leu Val Lys Asp Val Asn Glu Ala Leu Gln Thr Thr 
        355                 360                 365             


Glu Ser Leu Ile Asp Pro Ser Thr Val Tyr Val Asp Pro Asp Thr Trp 
    370                 375                 380                 


Thr Thr Arg Phe Val Ala Leu Val Gln Gln Ser Asp Phe Asp Asp Ala 
385                 390                 395                 400 


Ala Thr Glu Arg Ala Leu Gly Glu Gly Asn Tyr Thr Tyr Ile Thr Ala 
                405                 410                 415     


Ala Leu Asp Glu Tyr Tyr Asn Glu Thr Asp Gln Ala Val Tyr Met Asp 
            420                 425                 430         


Ser Val Met Val Pro Tyr Cys Ser Glu Ala Ala Leu Asp Ala Ile Arg 
        435                 440                 445             


Arg Arg Ile Ala Glu Glu Ala Arg Arg Val Leu Asp Phe Pro Leu Ile 
    450                 455                 460                 


Tyr Ala Asp Met Pro Val Glu Leu Glu Gly Ser Gly Val Glu Asn Val 
465                 470                 475                 480 


Thr Met Val Lys Leu Leu Met Pro Ala Ser Phe Asn Asn Glu Thr Val 
                485                 490                 495     


Ser Glu Leu Leu Glu Ala Ala Asp Leu Thr Gly Phe Ala His Ser Ala 
            500                 505                 510         


Ile Lys Glu Met Arg Gly Gly Glu Thr Arg Val Ser Val Val Leu Pro 
        515                 520                 525             


Asn Pro Pro Phe Asn Phe Ser Gly Val Thr Pro Asp Val Asp Gln Asp 
    530                 535                 540                 


Ile Arg Trp Tyr Val His Gly Asn Val Met Lys Gln Leu Asp Ile Cys 
545                 550                 555                 560 


Glu Lys Leu Asn Ala Lys Gly Ala Ala Pro Ala Pro Glu Pro Val Glu 
                565                 570                 575     


Asp Gly Asn Glu Ser Gly Gly Gly Val Val Tyr Thr Gly Glu Phe Cys 
            580                 585                 590         


Gln Ser Ser Ile Thr Asn Arg Thr Glu Thr Gln Asn Leu Lys Pro Pro 
        595                 600                 605             


Tyr Asp Gln Lys Asn Thr Tyr Glu Ile Phe Leu Pro Asn Lys Tyr Asp 
    610                 615                 620                 


Phe Asn Ala Ser Trp Cys Val Asp Ile Val Asp Trp Arg Glu Leu Asn 
625                 630                 635                 640 


Asp Trp Leu Ser Asn Val Thr Ala Gly Ser His Ile Glu Asp Ala Ser 
                645                 650                 655     


Trp Cys Gly Gln Gly Cys Ile Ile Ala Leu Ala Val Val Gly Ala Leu 
            660                 665                 670         


Leu Thr Thr Gly Leu Val Val Val Ala Val Val Leu Thr Ser Lys Arg 
        675                 680                 685             


Arg Arg Leu Ala Ala Val Val Ala Pro Pro Arg Pro Lys Phe Val Ser 
    690                 695                 700                 


Ala Thr Glu Asp Glu Glu Asp 
705                 710     


<210>  3
<211>  637
<212>  PRT
<213>  Trypanosoma congolense

<400>  3

His Val Lys Arg Asn Arg Arg Val Glu Thr Val Ala Gly Ala Tyr Gly 
1               5                   10                  15      


Leu Thr Gly Met Val Asp Gly Val Pro Pro Asp Ser Arg Leu Ser Ser 
            20                  25                  30          


Pro Met Ala Ile Cys Arg Gly Arg Thr Ala Asp Glu Ile Leu Val Gly 
        35                  40                  45              


Thr Ala Ser Gly Leu Arg Thr Tyr Ser Arg Ser Ser Gly Glu Leu Gly 
    50                  55                  60                  


Thr Leu Phe Thr Ser Ser Val Lys Val Val Gly Gly Ser Thr Gly Gly 
65                  70                  75                  80  


Ser Ala Tyr Gly Asn Pro Arg Ser Cys Val His Arg Gly Ile Asp Asn 
                85                  90                  95      


Ser Ser Val Ile Tyr Phe Val Asp Gly Gln Lys Asp Val Lys Tyr Tyr 
            100                 105                 110         


Lys Asn Asn Glu Val Leu Ser Lys Asp Thr Val Ala Asn Ala Ser Leu 
        115                 120                 125             


Thr Ala Met Thr Ile Phe Gly Gly Ser Leu Tyr Met Thr Asp Gln Ile 
    130                 135                 140                 


Asn Lys Ala Leu Val Thr Cys Lys Leu Ser Ala Asp Gly Ala Pro His 
145                 150                 155                 160 


Asp Cys Leu Ser Lys Lys Lys Leu Asn Asp Thr Cys Gly Phe Asn Thr 
                165                 170                 175     


Phe Thr Gly Ile Thr Ser Thr Ala Lys Gly Ile Phe Ile Ala Gly Gln 
            180                 185                 190         


Gly Ser Thr Thr Pro Gly Asn Ile Cys Trp Ile Gly Leu Asp Asp Thr 
        195                 200                 205             


Thr Val Thr Lys Leu Gly Gln Gly Glu Tyr Val Asp Val Ser Ser Thr 
    210                 215                 220                 


Ser Ser Gly Asp Leu Tyr Ala Val Ser Lys Thr Gln Ile Phe His Leu 
225                 230                 235                 240 


Glu Pro Ala Gly Ser Ala Pro Gln Leu Lys Thr Val Ala Gly Val Lys 
                245                 250                 255     


Gly Thr Pro Cys Leu Pro Thr Pro Asp Gly Glu Asp Ile Arg Phe Cys 
            260                 265                 270         


Glu Leu Asn Lys Ile Leu Ala Ile Ala Asp His Glu Leu Tyr Val Thr 
        275                 280                 285             


Ser Glu Arg Ser His Leu Leu Arg Ala Val Ile Leu Pro Pro Val Arg 
    290                 295                 300                 


Val Gln Ala Val Phe Ser Gly Arg Pro Val Pro Val Gly Tyr Pro Glu 
305                 310                 315                 320 


Gly Asp Thr Leu Asp Trp Ile Val Glu Asn Leu Val Lys Asp Val Asn 
                325                 330                 335     


Glu Ala Leu Gln Thr Thr Glu Ser Leu Ile Asp Pro Ser Thr Val Tyr 
            340                 345                 350         


Val Asp Pro Asp Thr Trp Thr Thr Arg Phe Val Ala Leu Val Gln Gln 
        355                 360                 365             


Ser Asp Phe Asp Asp Ala Ala Thr Glu Arg Ala Leu Gly Glu Gly Asn 
    370                 375                 380                 


Tyr Thr Tyr Ile Thr Ala Ala Leu Asp Glu Tyr Tyr Asn Glu Thr Asp 
385                 390                 395                 400 


Gln Ala Val Tyr Met Asp Ser Val Met Val Pro Tyr Cys Ser Glu Ala 
                405                 410                 415     


Ala Leu Asp Ala Ile Arg Arg Lys Ile Ala Glu Glu Ala Arg Arg Val 
            420                 425                 430         


Leu Asp Phe Pro Leu Ile Tyr Ala Asp Met Pro Val Glu Leu Glu Gly 
        435                 440                 445             


Ser Gly Ala Glu Asn Val Thr Met Val Lys Leu Leu Met Pro Ala Ser 
    450                 455                 460                 


Phe Asn Asn Glu Thr Val Ser Glu Leu Leu Glu Ala Ala Asp Leu Thr 
465                 470                 475                 480 


Gly Phe Ala His Ser Ala Ile Lys Glu Met Arg Gly Gly Glu Thr Arg 
                485                 490                 495     


Val Ser Val Val Leu Pro Asn Pro Pro Phe Asn Phe Ser Gly Val Thr 
            500                 505                 510         


Pro Asp Val Asp Gln Asp Ile Arg Trp Tyr Val His Gly Asn Val Met 
        515                 520                 525             


Lys Gln Leu Asp Ile Cys Glu Lys Leu Asn Ala Lys Gly Ala Ala Pro 
    530                 535                 540                 


Ala Pro Glu Pro Val Glu Asp Ser Asn Glu Ser Gly Gly Gly Val Val 
545                 550                 555                 560 


Tyr Thr Gly Glu Phe Cys Gln Ser Ser Ile Thr Asn Arg Thr Glu Thr 
                565                 570                 575     


Gln Asn Leu Lys Pro Pro Tyr Asp Gln Lys Asn Thr Tyr Glu Ile Phe 
            580                 585                 590         


Leu Pro Asn Lys Tyr Asp Phe Asn Ala Ser Trp Cys Val Asp Ile Val 
        595                 600                 605             


Asp Trp Arg Glu Leu Asn Asp Trp Leu Ser Asn Val Thr Val Gly Ser 
    610                 615                 620                 


His Ile Glu Asp Ala Ser Trp Cys Gly Gln Gly Cys Ile 
625                 630                 635         


<210>  4
<211>  711
<212>  PRT
<213>  Trypanosoma congolense

<400>  4

Met Arg Thr Gly Arg Ala Leu Gln Leu Leu Leu His Ala Thr Ile Ile 
1               5                   10                  15      


Phe Leu Gly Leu Val Glu Cys Ala Val Ala His Val Lys Arg Asn Arg 
            20                  25                  30          


Arg Val Glu Thr Val Ala Gly Ala Tyr Gly Leu Thr Gly Met Val Asp 
        35                  40                  45              


Gly Val Pro Pro Asp Ser Arg Leu Ser Ser Pro Met Ala Ile Cys Arg 
    50                  55                  60                  


Gly Arg Thr Ala Asp Glu Ile Leu Val Gly Thr Ala Ser Gly Leu Arg 
65                  70                  75                  80  


Thr Tyr Ser Arg Ser Ser Gly Glu Leu Gly Thr Leu Phe Thr Ser Ser 
                85                  90                  95      


Val Lys Val Val Gly Gly Ser Thr Gly Gly Ser Ala Tyr Gly Asn Pro 
            100                 105                 110         


Arg Ser Cys Val His Arg Gly Ile Asp Asn Ser Ser Val Ile Tyr Phe 
        115                 120                 125             


Val Asp Gly Gln Lys Asp Val Lys Tyr Tyr Lys Asn Asn Glu Val Leu 
    130                 135                 140                 


Ser Lys Asp Thr Val Ala Asn Ala Ser Leu Thr Ala Met Thr Ile Phe 
145                 150                 155                 160 


Gly Gly Ser Leu Tyr Met Thr Asp Gln Ile Asn Lys Ala Leu Val Thr 
                165                 170                 175     


Cys Lys Leu Ser Ala Asp Gly Ala Pro His Asp Cys Leu Ser Lys Lys 
            180                 185                 190         


Lys Leu Asn Asp Thr Cys Gly Phe Asn Thr Phe Thr Gly Ile Thr Ser 
        195                 200                 205             


Thr Ala Lys Gly Ile Phe Ile Ala Gly Gln Gly Ser Thr Thr Pro Gly 
    210                 215                 220                 


Asn Ile Cys Trp Ile Gly Leu Asp Asp Thr Thr Val Thr Lys Leu Gly 
225                 230                 235                 240 


Gln Gly Glu Tyr Val Asp Val Ser Ser Thr Ser Ser Gly Asp Leu Tyr 
                245                 250                 255     


Ala Val Ser Lys Thr Gln Ile Phe His Leu Glu Pro Ala Gly Ser Ala 
            260                 265                 270         


Pro Gln Leu Lys Thr Val Ala Gly Val Lys Gly Thr Pro Cys Leu Pro 
        275                 280                 285             


Thr Pro Asp Gly Glu Asp Ile Arg Phe Cys Glu Leu Asn Lys Ile Leu 
    290                 295                 300                 


Ala Ile Ala Asp His Glu Leu Tyr Val Thr Ser Glu Arg Ser His Leu 
305                 310                 315                 320 


Leu Arg Ala Val Ile Leu Pro Pro Val Arg Val Gln Ala Val Phe Ser 
                325                 330                 335     


Gly Arg Pro Val Pro Val Gly Tyr Pro Glu Gly Asp Thr Leu Asp Trp 
            340                 345                 350         


Ile Val Glu Asn Leu Val Lys Asp Val Asn Glu Ala Leu Gln Thr Thr 
        355                 360                 365             


Glu Ser Leu Ile Asp Pro Ser Thr Val Tyr Val Asp Pro Asp Thr Trp 
    370                 375                 380                 


Thr Thr Arg Phe Val Ala Leu Val Gln Gln Ser Asp Phe Asp Asp Ala 
385                 390                 395                 400 


Ala Thr Glu Arg Ala Leu Gly Glu Gly Asn Tyr Thr Tyr Ile Thr Ala 
                405                 410                 415     


Ala Leu Asp Glu Tyr Tyr Asn Glu Thr Asp Gln Ala Val Tyr Met Asp 
            420                 425                 430         


Ser Val Met Val Pro Tyr Cys Ser Glu Ala Ala Leu Asp Ala Ile Arg 
        435                 440                 445             


Arg Lys Ile Ala Glu Glu Ala Arg Arg Val Leu Asp Phe Pro Leu Ile 
    450                 455                 460                 


Tyr Ala Asp Met Pro Val Glu Leu Glu Gly Ser Gly Ala Glu Asn Val 
465                 470                 475                 480 


Thr Met Val Lys Leu Leu Met Pro Ala Ser Phe Asn Asn Glu Thr Val 
                485                 490                 495     


Ser Glu Leu Leu Glu Ala Ala Asp Leu Thr Gly Phe Ala His Ser Ala 
            500                 505                 510         


Ile Lys Glu Met Arg Gly Gly Glu Thr Arg Val Ser Val Val Leu Pro 
        515                 520                 525             


Asn Pro Pro Phe Asn Phe Ser Gly Val Thr Pro Asp Val Asp Gln Asp 
    530                 535                 540                 


Ile Arg Trp Tyr Val His Gly Asn Val Met Lys Gln Leu Asp Ile Cys 
545                 550                 555                 560 


Glu Lys Leu Asn Ala Lys Gly Ala Ala Pro Ala Pro Glu Pro Val Glu 
                565                 570                 575     


Asp Ser Asn Glu Ser Gly Gly Gly Val Val Tyr Thr Gly Glu Phe Cys 
            580                 585                 590         


Gln Ser Ser Ile Thr Asn Arg Thr Glu Thr Gln Asn Leu Lys Pro Pro 
        595                 600                 605             


Tyr Asp Gln Lys Asn Thr Tyr Glu Ile Phe Leu Pro Asn Lys Tyr Asp 
    610                 615                 620                 


Phe Asn Ala Ser Trp Cys Val Asp Ile Val Asp Trp Arg Glu Leu Asn 
625                 630                 635                 640 


Asp Trp Leu Ser Asn Val Thr Val Gly Ser His Ile Glu Asp Ala Ser 
                645                 650                 655     


Trp Cys Gly Gln Gly Cys Ile Ile Ala Leu Ala Val Val Gly Ala Leu 
            660                 665                 670         


Leu Thr Thr Gly Leu Val Val Val Ala Val Val Leu Thr Ser Lys Arg 
        675                 680                 685             


Arg Arg Leu Ala Ala Val Val Ala Pro Pro Arg Pro Lys Phe Val Ser 
    690                 695                 700                 


Ala Thr Glu Asp Glu Glu Asp 
705                 710     


<210>  5
<211>  818
<212>  PRT
<213>  Trypanosoma brucei


<220>
<221>  misc_feature
<222>  (108)..(108)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (167)..(167)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (403)..(403)
<223>  Xaa can be any naturally occurring amino acid

<400>  5

Met Cys Phe Ile Phe Gly Val Glu Met Ser Asn Leu Ala Lys Arg Pro 
1               5                   10                  15      


Met Ser Leu Arg Lys Leu Pro Gln Leu Phe Leu Leu Ile Met Ile Gly 
            20                  25                  30          


Ile Ala Phe Val Ala Val Glu Cys Ile Gly Thr Pro Val Lys Leu Pro 
        35                  40                  45              


Arg Arg Val Asp Thr Val Ala Gly Gln Phe Gly Val Glu Gly Glu Thr 
    50                  55                  60                  


Asn Gly Tyr Pro Asn Thr Thr Arg Leu Thr Glu Pro Tyr Ala Leu Cys 
65                  70                  75                  80  


Arg Gly Arg Thr Asn Asp Glu Ile Leu Val Gly Ser Ser Asn Ser Phe 
                85                  90                  95      


Arg Asn Tyr Ser Arg Lys Thr Lys Glu Thr Gly Xaa Tyr Leu Arg Tyr 
            100                 105                 110         


Asn Val Gly Asp Ser Val Ile Ser Gly Ser Ser Thr Ile Asn Lys Pro 
        115                 120                 125             


Arg Ser Cys Val Arg Arg Gly Ser Gly Asn His Thr Ile Ile Tyr Phe 
    130                 135                 140                 


Val Asp Asp Gln Lys Asp Ile Lys Tyr Ile Val Gly Asp Asp Val Ser 
145                 150                 155                 160 


Ser Phe Ser Val Pro Thr Xaa Gly Ser Leu Asn Ala Val Ala Val His 
                165                 170                 175     


Glu Gly Ser Leu Tyr Val Thr Asp Gln Asn Asn Lys Ser Val Trp Lys 
            180                 185                 190         


Cys Gly Leu Gly Gly Ala Gly Lys Pro Gln Ser Cys Glu Glu Lys Lys 
        195                 200                 205             


Phe Thr Ser Val Thr Leu Asp Ala Lys Pro Glu Gly Ile Ala Val Thr 
    210                 215                 220                 


Ser Lys Gly Ile Phe Val Thr Ala Arg Asp Ser Ser Asn Lys Gly Ala 
225                 230                 235                 240 


Leu Leu Trp Leu Asp Met Asn Gly Ser Asn Arg Lys Gly Asn Val Ser 
                245                 250                 255     


Gly Gly Phe Val Asp Val Phe Ser Thr Glu Ser Gly Met Leu Tyr Ala 
            260                 265                 270         


Ala Thr Glu Lys Glu Leu Tyr Thr Val Thr Ala Thr Asp Thr Ser Leu 
        275                 280                 285             


Ser Val Thr Leu Phe Ala Gly Lys Asn Thr Ser Ser Cys Tyr Phe Pro 
    290                 295                 300                 


Thr Asn Gly Glu Asp Ile Val Leu Cys Asp Asn Ser Arg Leu Leu Val 
305                 310                 315                 320 


Ile Glu Glu Tyr Glu Met Tyr Val Thr Ser Arg Ala Lys His Thr Met 
                325                 330                 335     


Arg Ala Leu Thr Leu Pro Pro Val Asn Leu Thr Ala Ile Phe Arg Gly 
            340                 345                 350         


Arg Pro Ala Pro Val Gly Tyr Pro Asn Thr Thr Ile Met Glu Gln Phe 
        355                 360                 365             


Val Ala Ser Leu Thr Glu Asp Val Asn Lys Ala Leu Gly Thr Asn Asp 
    370                 375                 380                 


Ser Tyr Val Asp Pro Asp Ser Val Arg Val Asp Pro Asp Thr Trp Glu 
385                 390                 395                 400 


Thr Asn Xaa Thr Val Phe Val Gln Gln Thr Arg Phe Asp Asn Thr Thr 
                405                 410                 415     


Glu Glu Lys Leu Arg Ser Leu Thr Tyr Thr Gln Thr Asp Lys Thr Val 
            420                 425                 430         


Asp Glu Tyr Tyr Gly Leu Thr Asp Glu Tyr Val Tyr Ile Asp Thr Val 
        435                 440                 445             


Leu Val Pro Phe Cys Asp Asp Ala Ser Leu Val Thr Ile Gln Arg Ala 
    450                 455                 460                 


Leu Ala Arg Glu Ala Gly Arg Ala Leu Asn Phe Ser Leu Val Tyr Ala 
465                 470                 475                 480 


Asp Lys Pro Ile Thr Phe Gly Ser Asp Val Ala Glu Asn Val Thr Ala 
                485                 490                 495     


Val Lys Leu Leu Met Pro His Ser Phe Lys Asn Ala Thr Thr Pro Lys 
            500                 505                 510         


Gln Leu Ser Ala Ala Asn Leu Thr Asp Phe Ala His Asn Leu Val Lys 
        515                 520                 525             


Asp Leu Arg Ala Ser Asp Thr Arg Val Asp Ile Thr Phe Pro Asp Pro 
    530                 535                 540                 


Pro Phe Asn Phe Ser Ala Val Val Pro Glu Arg Glu Gln Glu Val Arg 
545                 550                 555                 560 


Trp Phe Val His Gly Lys Val Met Lys Gln Leu Glu Ile Cys Glu Arg 
                565                 570                 575     


Leu Gly Ser Gln Gly Asp Ala Ala Val Ile Ala Ala Ala Ala Asp Ala 
            580                 585                 590         


Thr Ala Arg Gly Lys Ala Asn Val Thr Leu Asn Thr Ser Gly Val Lys 
        595                 600                 605             


Ala Asn Asp Thr Gly Val Gly Pro Asn Thr Thr Asn Thr Ala Gly Gly 
    610                 615                 620                 


Ala Asn Thr Thr Ala Asn Val Ala Thr Asn Gly Thr Ala Asn Val Ile 
625                 630                 635                 640 


Val Asn Pro Ser Thr Asn Ala Thr Pro Thr Gly Thr Ser Asn Ala Ser 
                645                 650                 655     


Val Thr Asn Thr Thr Glu Arg Ala Val Pro Val Val Ala Pro Thr Gln 
            660                 665                 670         


Pro Ser Asn Gly Tyr Ala Glu Cys Arg Ser Ala Ile Thr Asn Arg Thr 
        675                 680                 685             


Glu Thr Gln Asn Met Glu Pro Pro Tyr Asp Arg Lys His Arg Tyr Glu 
    690                 695                 700                 


Val Phe Leu Pro Lys Lys Tyr Asp Phe Asn Val Ser Trp Cys Val Asp 
705                 710                 715                 720 


Ile Ile Asp Trp Arg Asp Leu Asp Glu Met Leu Asn Asn Arg Thr Asp 
                725                 730                 735     


Glu Val Val Glu Lys Ser Leu Ser Trp Cys Gly His Gly Cys Ile Ile 
            740                 745                 750         


Ala Phe Ala Val Val Gly Ser Leu Ile Ala Ala Cys Leu Val Val Leu 
        755                 760                 765             


Ala Val Val Leu Thr Ser Lys Arg Arg Arg Leu Ala Ala Val Val Ala 
    770                 775                 780                 


Pro Pro Arg Pro Lys Phe Val Ser Thr Val Glu Asp Asp Glu Glu Asp 
785                 790                 795                 800 


Arg Val Ser Asn Ile Gly Val Pro Leu Thr Asp Gly Lys Gly Thr Thr 
                805                 810                 815     


Ala Pro 
        


<210>  6
<211>  818
<212>  PRT
<213>  Trypanosoma brucei


<220>
<221>  misc_feature
<222>  (287)..(287)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (331)..(331)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (403)..(403)
<223>  Xaa can be any naturally occurring amino acid

<400>  6

Met Cys Phe Ile Phe Gly Val Glu Met Ser Asn Leu Ala Lys Arg Pro 
1               5                   10                  15      


Met Ser Leu Arg Lys Leu Pro Gln Leu Phe Leu Leu Ile Met Ile Gly 
            20                  25                  30          


Ile Ala Phe Val Ala Val Glu Cys Ile Gly Ala Pro Val Lys Leu Pro 
        35                  40                  45              


Arg Arg Val Asp Thr Val Ala Gly Gln Phe Gly Phe Asp Gly Thr Thr 
    50                  55                  60                  


Asp Gly Ser Ser Asn Val Ser Met Leu Ser Ser Pro Tyr Ala Leu Cys 
65                  70                  75                  80  


Arg Gly Arg Thr Asn Asp Glu Ile Leu Val Gly Ser Ser Asn Ser Phe 
                85                  90                  95      


Arg Asn Tyr Ser Arg Lys Thr Lys Glu Thr Gly Thr Phe Leu Arg Gly 
            100                 105                 110         


Gly Pro Thr Gly Gly Leu Val Ser Ala Asp Ala Lys Ile Ser Lys Pro 
        115                 120                 125             


Arg Ser Cys Val Arg Arg Gly Ser Gly Asn His Thr Ile Ile Tyr Phe 
    130                 135                 140                 


Val Asp Asp Gln Asn Gly Leu Lys Tyr Ile Asn Asp Asn Glu Ile Gln 
145                 150                 155                 160 


His Val Thr Val Gly Asp Gly Leu Ser Leu Thr Ser Val Ala Ile Tyr 
                165                 170                 175     


Glu Lys Asp Leu Tyr Val Thr Asp Gln Asn Asn Lys Ser Val Trp Arg 
            180                 185                 190         


Cys Asn Val Gly Gly Ala Gly Lys Pro Gln Asn Cys Glu Glu Lys Lys 
        195                 200                 205             


Phe Thr Gly Leu Thr Phe Thr Ala Lys Pro Glu Gly Ile Ala Val Thr 
    210                 215                 220                 


Ser Lys Gly Ile Phe Val Ala Ala Arg Asp Ser Ser Asn Lys Gly Ala 
225                 230                 235                 240 


Leu Leu Trp Leu Asp Met Asn Gly Gly Gly Ser Lys Gly Asn Val Ser 
                245                 250                 255     


Gly Gly Phe Val Asp Val Phe Ser Thr Glu Ser Gly Met Leu Tyr Ala 
            260                 265                 270         


Ala Thr Glu Lys Glu Leu Tyr Thr Val Thr Ala Thr Asp Ser Xaa Phe 
        275                 280                 285             


Ser Val Thr Leu Phe Ala Gly Lys Asn Thr Ser Ser Cys Tyr Ser His 
    290                 295                 300                 


Ala Asn Gly Glu Asp Ile Val Leu Cys Asp Asn Ser Arg Leu Leu Val 
305                 310                 315                 320 


Ile Glu Glu Tyr Glu Met Tyr Val Thr Ser Xaa Glu Lys His Thr Met 
                325                 330                 335     


Arg Ala Leu Thr Leu Pro Pro Val Asn Leu Thr Ala Ile Phe Arg Gly 
            340                 345                 350         


Arg Pro Ala Pro Val Gly Tyr Pro Asn Thr Thr Ile Met Glu Gln Phe 
        355                 360                 365             


Val Ala Ser Leu Thr Glu Asp Val Asn Lys Ala Leu Gly Thr Asn Asp 
    370                 375                 380                 


Ser Tyr Val Asp Pro Asp Ser Val Arg Val Asp Pro Asp Thr Trp Glu 
385                 390                 395                 400 


Thr Asn Xaa Thr Val Phe Val Gln Gln Thr Arg Phe Asp Asn Thr Thr 
                405                 410                 415     


Glu Glu Lys Leu Arg Ser Leu Thr Tyr Thr Gln Thr Asp Lys Thr Val 
            420                 425                 430         


Asp Glu Tyr Tyr Gly Leu Thr Asp Glu Tyr Val Tyr Ile Asp Thr Val 
        435                 440                 445             


Leu Val Pro Phe Cys Asp Asp Ala Ser Leu Val Thr Ile Gln Arg Ala 
    450                 455                 460                 


Leu Ala Arg Glu Ala Gly Arg Ala Leu Asn Phe Ser Leu Ile Tyr Ala 
465                 470                 475                 480 


Asp Lys Pro Ile Thr Phe Gly Ser Asp Val Ala Glu Asn Val Thr Ala 
                485                 490                 495     


Val Lys Leu Leu Met Pro His Ser Phe Lys Asn Ala Thr Thr Pro Lys 
            500                 505                 510         


Gln Leu Ser Ala Ala Asn Leu Thr Asp Phe Ala His Asn Leu Val Lys 
        515                 520                 525             


Asp Leu Arg Ala Ser Asp Thr Arg Val Asp Ile Thr Phe Pro Asp Pro 
    530                 535                 540                 


Pro Phe Asn Phe Ser Ala Val Val Pro Glu Arg Glu Gln Glu Val Arg 
545                 550                 555                 560 


Trp Phe Val His Gly Lys Val Met Lys Gln Leu Glu Ile Cys Glu Arg 
                565                 570                 575     


Leu Gly Ser Gln Gly Asp Ala Ala Val Ile Ala Ala Ala Ala Ala Ala 
            580                 585                 590         


Thr Ala Arg Gly Lys Ala Asn Val Thr Leu Asn Thr Ser Gly Val Lys 
        595                 600                 605             


Ala Asn Asp Thr Gly Val Gly Pro Asn Thr Thr Asn Thr Ala Gly Gly 
    610                 615                 620                 


Ala Asn Thr Thr Ala Asn Val Val Ala Asn Gly Thr Ala Asn Val Ile 
625                 630                 635                 640 


Val Asn Pro Ser Thr Asn Ala Thr Pro Thr Gly Thr Ser Asn Ala Ser 
                645                 650                 655     


Val Thr Asn Thr Thr Glu Arg Ala Val Pro Val Val Ala Pro Thr Gln 
            660                 665                 670         


Pro Ser Asn Gly Tyr Ala Glu Cys Arg Ser Ala Ile Thr Asn Arg Thr 
        675                 680                 685             


Glu Thr Gln Asn Met Glu Pro Pro Tyr Asp Arg Lys His Arg Tyr Glu 
    690                 695                 700                 


Val Phe Leu Pro Lys Lys Tyr Asp Phe Asn Val Ser Trp Cys Val Asp 
705                 710                 715                 720 


Ile Ile Asp Trp Arg Asp Leu Asp Glu Met Leu Asn Asn Arg Thr Asp 
                725                 730                 735     


Glu Val Val Glu Lys Ser Leu Ser Trp Cys Gly His Gly Cys Ile Ile 
            740                 745                 750         


Ala Phe Ala Val Val Gly Ser Leu Ile Ala Ala Cys Leu Val Val Leu 
        755                 760                 765             


Ala Val Val Leu Thr Ser Lys Arg Arg Arg Leu Ala Ala Val Val Ala 
    770                 775                 780                 


Pro Pro Arg Pro Lys Phe Val Ser Thr Val Glu Asp Asp Glu Glu Asp 
785                 790                 795                 800 


Arg Val Ser Asn Ile Gly Val Pro Leu Thr Asp Gly Lys Gly Thr Thr 
                805                 810                 815     


Ala Pro 
        


<210>  7
<211>  750
<212>  PRT
<213>  Trypanosoma brucei


<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (124)..(124)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (220)..(220)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (356)..(356)
<223>  Xaa can be any naturally occurring amino acid

<400>  7

Met Pro Leu Trp Lys Gln Thr Asn Cys Glu Val Glu Thr Met Asn Val 
1               5                   10                  15      


Arg Glu Val Val Gly Thr Val His Leu Gly Tyr Val Ser Gln Met Leu 
            20                  25                  30          


Leu Leu Val Ala Thr Val Xaa Thr Ile Val Val Arg Ser Gly Ala Ala 
        35                  40                  45              


Pro Ile Glu Leu Lys Arg His Val Thr Thr Val Ala Gly Lys Tyr Gly 
    50                  55                  60                  


His Ile Gly Asp Lys Asp Gly Phe Pro Gly Met Ser Glu Leu Ser Ser 
65                  70                  75                  80  


Pro His Ala Met Cys Arg Gly Arg Asn Ser Asp Glu Ile Leu Leu Gly 
                85                  90                  95      


Thr Val Asp Arg Phe Arg Ala Phe Ser Arg Lys Asn Arg Glu Thr Thr 
            100                 105                 110         


Thr Ile Thr Ala Trp Glu Thr Asp Glu Asp Gln Xaa Ser Gly Ser Arg 
        115                 120                 125             


Ser Val Lys Val Asp Lys Pro Arg Ala Cys Val Gln Trp Thr Val Gly 
    130                 135                 140                 


Gly Ser Thr Phe Val Tyr Phe Val Glu Ser Met Gly Glu Val Lys Tyr 
145                 150                 155                 160 


Phe Lys Asp Ser Gly Val Phe Ser His Asp Val Val Arg Asn Gly Ser 
                165                 170                 175     


Leu Thr Gly Val Ala Leu Tyr Gly Asn His Leu Tyr Leu Thr Glu Gln 
            180                 185                 190         


Asn Thr Asn Thr Val Trp Thr Cys Glu Val Gly Ser Asp Gly Asp Pro 
        195                 200                 205             


Ile Ala Cys His Ser His Val Ala Leu Ser Ala Xaa Cys Ser Ile Tyr 
    210                 215                 220                 


Gly Pro Ile Gly Ile Ala Ala Thr Gln Gln Gly Ile Phe Val Val Ala 
225                 230                 235                 240 


Arg Gly Pro Ala Lys Gln Gly Thr Ile Cys Trp Phe Asp Leu Gln Gly 
                245                 250                 255     


His Lys Ile Ala Glu Val Asp Gly Glu Tyr Val Asp Ile Thr Ser Thr 
            260                 265                 270         


Arg Ser Gly Asp Leu Leu Ala Ala Thr Gln Asn Glu Leu His Arg Val 
        275                 280                 285             


Ser Thr Asp Gly Asn Lys Leu Thr Thr Lys Arg Phe Ala Gly Gly Ser 
    290                 295                 300                 


Thr Asn Ser Cys Leu Pro Asn Thr Glu Gly Asp Asp Thr Leu Leu Cys 
305                 310                 315                 320 


Glu Ile Thr Arg Leu Leu Val Val Thr Glu Tyr Glu Met Tyr Val Thr 
                325                 330                 335     


Ser Glu Lys Lys Ser Val Leu Arg Ser Val Thr Leu Pro Pro Val Tyr 
            340                 345                 350         


Val Gln Gly Xaa Phe Pro Gly Arg Pro Leu Pro Val Gly Tyr Pro Asp 
        355                 360                 365             


Lys Asp Ile Met Glu Trp Ile Val Gly Asn Leu Thr Glu Asp Ile Asn 
    370                 375                 380                 


Thr Ala Leu Gly Thr Thr Glu Ser Ile Val Ala Ser Ser Ser Val His 
385                 390                 395                 400 


Val Asp Ser Thr Thr Trp Leu Thr Asn Phe Thr Ala Gly Val Gln Gln 
                405                 410                 415     


Pro Asp Phe Asp Asp Glu Lys Thr Glu Gln Ala Leu His Lys Ser Asn 
            420                 425                 430         


Tyr Glu His Thr Lys Glu Ala Ala Asp Glu Tyr Tyr Asn Leu Thr Asp 
        435                 440                 445             


Glu Gln Val Tyr Met Asp Ser Thr Met Val Pro Tyr Cys Asn Arg Leu 
    450                 455                 460                 


Ser Leu Asp Ala Leu Arg Arg Lys Leu Ala Lys Glu Ala Gly Glu Val 
465                 470                 475                 480 


Leu Asn Phe Thr Leu Ile Tyr Ala Asp Met Pro Leu Lys Ala Glu Ser 
                485                 490                 495     


Ser Asp Ala Gly Asn Ile Thr Thr Val Lys Leu Leu Met Pro Ala Ser 
            500                 505                 510         


Phe Asn Asn Thr Val Thr His Asp Leu Leu Ser Asp Ala Asn Leu Thr 
        515                 520                 525             


Glu Thr Ala His Ser Phe Ile Lys Tyr Leu Arg Ser Ser Asp Thr His 
    530                 535                 540                 


Val Asp Val Thr Phe Ser Asn Pro Pro Phe Asn Phe Ser Ser Leu Thr 
545                 550                 555                 560 


Pro Asp Glu Glu Gln Glu Val Arg Trp Tyr Ile His Asp Glu Val Met 
                565                 570                 575     


Asn Gln Ile Lys Lys Cys Glu Glu Arg Ser Thr Gly Arg Ser Met Ala 
            580                 585                 590         


Arg Arg Glu Glu Val Gly Asp Tyr Ser Arg Thr Thr Ile Ala Thr Ala 
        595                 600                 605             


Leu Asp Ser Asn Val Thr Gly Val Cys Gln Ser Thr Ile Thr Asn Arg 
    610                 615                 620                 


Thr Val Ser Leu Phe Tyr Gln Pro Pro Tyr Val Glu Met Ser Leu Tyr 
625                 630                 635                 640 


Glu Val Phe Ile Pro Gly Asn Tyr Thr Phe Asp Val Ser Glu Cys Val 
                645                 650                 655     


Gly Glu Ile Asp Trp Gln Asp Leu Asn Asp His Leu Asn Asn Asp Thr 
            660                 665                 670         


Val Arg Pro Thr Thr Glu Lys Ala Pro Lys Cys Gly Arg Val Cys Leu 
        675                 680                 685             


Ile Ile Ile Ala Val Val Cys Ala Leu Ile Val Ala Val Leu Ile Val 
    690                 695                 700                 


Leu Ala Val Val Phe Thr Ser Lys Arg Arg Arg Leu Ala Ala Val Val 
705                 710                 715                 720 


Ala Pro Ala Arg Pro Lys Phe Val Ser Thr Leu Asp Glu Asp Glu Gln 
                725                 730                 735     


Asp Tyr Ala Ser Ala Tyr Gly Asn Lys Glu Arg Val Glu Gln 
            740                 745                 750 


<210>  8
<211>  750
<212>  PRT
<213>  Trypanosoma brucei


<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (124)..(124)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (220)..(220)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (356)..(356)
<223>  Xaa can be any naturally occurring amino acid

<400>  8

Met Pro Leu Trp Lys Gln Thr Asn Cys Glu Val Glu Thr Met Asn Val 
1               5                   10                  15      


Arg Glu Val Val Gly Thr Val His Leu Gly Tyr Val Ser Gln Met Leu 
            20                  25                  30          


Leu Leu Val Ala Thr Val Xaa Thr Ile Val Val Arg Ser Gly Ala Ala 
        35                  40                  45              


Pro Ile Glu Leu Lys Arg His Val Thr Thr Val Ala Gly Lys Tyr Gly 
    50                  55                  60                  


His Ile Gly Asp Lys Asp Gly Phe Pro Gly Met Ser Glu Leu Ser Ser 
65                  70                  75                  80  


Pro His Ala Met Cys Arg Gly Arg Asn Ser Asp Glu Ile Leu Leu Gly 
                85                  90                  95      


Thr Val Asp Arg Phe Arg Ala Phe Ser Arg Lys Asn Arg Glu Thr Thr 
            100                 105                 110         


Thr Ile Thr Ala Trp Glu Thr Asp Glu Asp Gln Xaa Ser Gly Ser Arg 
        115                 120                 125             


Ser Val Lys Val Asp Lys Pro Arg Ala Cys Val Gln Trp Thr Val Gly 
    130                 135                 140                 


Gly Ser Thr Phe Val Tyr Phe Val Glu Ser Met Gly Glu Val Lys Tyr 
145                 150                 155                 160 


Phe Lys Asp Ser Gly Val Phe Ser His Asp Val Val Arg Asn Gly Ser 
                165                 170                 175     


Leu Thr Gly Val Ala Leu Tyr Gly Asn His Leu Tyr Leu Thr Glu Gln 
            180                 185                 190         


Asn Thr Asn Thr Val Trp Thr Cys Glu Val Gly Ser Asp Gly Asp Pro 
        195                 200                 205             


Ile Ala Cys His Ser His Val Ala Leu Ser Ala Xaa Cys Ser Ile Tyr 
    210                 215                 220                 


Gly Pro Ile Gly Ile Ala Ala Thr Gln Gln Gly Ile Phe Val Val Ala 
225                 230                 235                 240 


Arg Gly Pro Ala Lys Gln Gly Thr Ile Cys Trp Phe Asp Leu Gln Gly 
                245                 250                 255     


His Lys Ile Ala Glu Val Asp Gly Glu Tyr Val Asp Ile Thr Ser Thr 
            260                 265                 270         


Arg Ser Gly Asp Leu Leu Ala Ala Thr Gln Asn Glu Leu His Arg Val 
        275                 280                 285             


Ser Thr Asp Gly Asn Lys Leu Thr Thr Lys Arg Phe Ala Gly Gly Ser 
    290                 295                 300                 


Thr Asn Ser Cys Leu Pro Asn Thr Glu Gly Asp Asp Thr Leu Leu Cys 
305                 310                 315                 320 


Glu Ile Thr Arg Leu Leu Val Val Thr Glu Tyr Glu Met Tyr Val Thr 
                325                 330                 335     


Ser Glu Lys Lys Ser Val Leu Arg Ser Val Thr Leu Pro Pro Val Tyr 
            340                 345                 350         


Val Gln Gly Xaa Phe Pro Gly Arg Pro Leu Pro Val Gly Tyr Pro Asp 
        355                 360                 365             


Lys Asp Ile Met Glu Trp Ile Val Gly Asn Leu Thr Glu Asp Ile Asn 
    370                 375                 380                 


Thr Ala Leu Gly Thr Thr Glu Ser Ile Val Ala Ser Ser Ser Val His 
385                 390                 395                 400 


Val Asp Ser Thr Thr Trp Leu Thr Asn Phe Thr Ala Gly Val Gln Gln 
                405                 410                 415     


Pro Asp Phe Asp Asp Glu Lys Thr Glu Gln Ala Leu His Lys Ser Asn 
            420                 425                 430         


Tyr Glu His Thr Lys Glu Ala Ala Asp Glu Tyr Tyr Asn Leu Thr Asp 
        435                 440                 445             


Glu Gln Val Tyr Met Asp Ser Thr Met Val Pro Tyr Cys Asn Arg Leu 
    450                 455                 460                 


Ser Leu Asp Ala Leu Arg Arg Lys Leu Ala Lys Glu Ala Gly Glu Val 
465                 470                 475                 480 


Leu Asn Phe Thr Leu Ile Tyr Ala Asp Met Pro Leu Lys Ala Glu Ser 
                485                 490                 495     


Ser Asp Ala Gly Asn Ile Thr Thr Val Lys Leu Leu Met Pro Ala Ser 
            500                 505                 510         


Phe Asn Asn Thr Val Thr His Asp Leu Leu Ser Asp Ala Asn Leu Thr 
        515                 520                 525             


Glu Thr Ala His Ser Phe Ile Lys Tyr Leu Arg Ser Ser Asp Thr His 
    530                 535                 540                 


Val Asp Val Thr Phe Ser Asn Pro Pro Phe Asn Phe Ser Ser Leu Thr 
545                 550                 555                 560 


Pro Asp Glu Glu Gln Glu Val Arg Trp Tyr Ile His Asp Glu Val Met 
                565                 570                 575     


Asn Gln Ile Lys Lys Cys Glu Glu Arg Ser Thr Gly Arg Ser Met Ala 
            580                 585                 590         


Arg Arg Glu Glu Val Gly Asp Tyr Ser Arg Thr Thr Ile Ala Thr Ala 
        595                 600                 605             


Leu Asp Ser Asn Val Thr Gly Val Cys Gln Ser Thr Ile Thr Asn Arg 
    610                 615                 620                 


Thr Val Ser Leu Phe Tyr Gln Pro Pro Tyr Val Glu Met Ser Leu Tyr 
625                 630                 635                 640 


Glu Val Phe Ile Pro Gly Asn Tyr Thr Phe Asp Val Ser Glu Cys Val 
                645                 650                 655     


Gly Glu Ile Asp Trp Gln Asp Leu Asn Asp His Leu Asn Asn Asp Thr 
            660                 665                 670         


Val Arg Pro Thr Thr Glu Lys Ala Pro Lys Cys Gly Arg Val Cys Leu 
        675                 680                 685             


Ile Ile Ile Ala Val Val Cys Ala Leu Ile Val Ala Val Leu Ile Val 
    690                 695                 700                 


Leu Ala Val Val Phe Thr Ser Lys Arg Arg Arg Leu Ala Ala Val Val 
705                 710                 715                 720 


Ala Pro Ala Arg Pro Lys Phe Val Ser Thr Leu Asp Glu Asp Glu Gln 
                725                 730                 735     


Asp Tyr Ala Ser Ala Tyr Gly Asn Lys Glu Arg Val Glu Gln 
            740                 745                 750 


<210>  9
<211>  818
<212>  PRT
<213>  Trypanosoma brucei

<400>  9

Met Cys Phe Ile Phe Gly Val Glu Met Ser Asn Leu Ala Lys Arg Pro 
1               5                   10                  15      


Met Ser Leu Arg Lys Leu Pro Gln Leu Phe Leu Leu Ile Met Ile Gly 
            20                  25                  30          


Ile Ala Phe Val Ala Val Glu Cys Ile Gly Ala Pro Val Lys Leu Pro 
        35                  40                  45              


Arg Arg Val Asp Thr Val Ala Gly Gln Phe Gly Val Glu Gly Glu Thr 
    50                  55                  60                  


Asn Gly Tyr Pro Asn Thr Thr Arg Leu Thr Glu Pro Tyr Ala Leu Cys 
65                  70                  75                  80  


Arg Gly Arg Thr Asn Asp Glu Ile Leu Val Gly Ser Ser Asn Ser Phe 
                85                  90                  95      


Arg Asn Tyr Ser Arg Lys Thr Lys Glu Thr Gly Thr Tyr Leu Arg Tyr 
            100                 105                 110         


Asn Val Gly Asp Ser Val Ile Ser Gly Ser Ser Thr Ile Asn Lys Pro 
        115                 120                 125             


Arg Ser Cys Val Arg Arg Gly Ser Gly Asn His Thr Ile Ile Tyr Phe 
    130                 135                 140                 


Val Asp Asp Gln Lys Asp Ile Lys Tyr Ile Val Gly Asp Asp Val Ser 
145                 150                 155                 160 


Ser Phe Ser Val Pro Thr Arg Gly Ser Leu Asn Ala Val Ala Val His 
                165                 170                 175     


Glu Gly Ser Leu Tyr Val Thr Asp Gln Asn Asn Lys Ser Val Trp Lys 
            180                 185                 190         


Cys Gly Leu Gly Gly Ala Gly Lys Pro Gln Ser Cys Glu Glu Lys Lys 
        195                 200                 205             


Phe Thr Ser Val Thr Leu Asp Ala Lys Pro Glu Gly Ile Ala Val Thr 
    210                 215                 220                 


Ser Lys Gly Ile Phe Val Ala Ala Arg Asp Ser Ser Asn Lys Gly Ala 
225                 230                 235                 240 


Leu Leu Trp Leu Asp Met Asn Gly Ser Asn Arg Lys Gly Asn Val Ser 
                245                 250                 255     


Gly Gly Phe Val Asp Val Phe Ser Thr Glu Ser Gly Met Leu Tyr Ala 
            260                 265                 270         


Ala Thr Glu Lys Glu Leu Tyr Thr Val Thr Ala Thr Asp Ser Ala Phe 
        275                 280                 285             


Ser Val Thr Leu Phe Ala Gly Lys Asn Thr Ser Gln Cys Tyr Phe Pro 
    290                 295                 300                 


Thr Asn Gly Glu Asp Ile Val Leu Cys Asp Asn Ser Arg Leu Leu Val 
305                 310                 315                 320 


Ile Glu Glu Tyr Glu Met Tyr Val Thr Ser Lys Glu Lys His Thr Met 
                325                 330                 335     


Arg Ala Leu Thr Leu Pro Pro Val Asn Leu Thr Ala Ile Phe Arg Gly 
            340                 345                 350         


Arg Pro Ala Pro Val Gly Tyr Pro Asn Thr Thr Ile Met Glu Gln Phe 
        355                 360                 365             


Val Ala Ser Leu Thr Glu Asp Val Asn Lys Ala Leu Gly Thr Asn Asp 
    370                 375                 380                 


Ser Tyr Val Asp Pro Asp Ser Val Arg Val Asp Pro Asp Thr Trp Glu 
385                 390                 395                 400 


Thr Asn Phe Thr Val Phe Val Gln Gln Thr Arg Phe Asp Asn Thr Thr 
                405                 410                 415     


Glu Glu Lys Leu Arg Ser Leu Thr Tyr Thr Gln Thr Asp Lys Thr Val 
            420                 425                 430         


Asp Glu Tyr Tyr Gly Leu Thr Asp Glu Tyr Val Tyr Ile Asp Thr Val 
        435                 440                 445             


Leu Val Pro Phe Cys Asp Asp Ala Ser Leu Val Thr Ile Gln Arg Ala 
    450                 455                 460                 


Leu Ala Arg Glu Ala Gly Arg Ala Leu Asn Phe Ser Leu Ile Tyr Ala 
465                 470                 475                 480 


Asp Lys Pro Ile Thr Phe Gly Ser Asp Val Ala Glu Asn Val Thr Ala 
                485                 490                 495     


Val Lys Leu Leu Met Pro His Ser Phe Lys Asn Ala Thr Thr Pro Lys 
            500                 505                 510         


Gln Leu Ser Ala Ala Asn Leu Thr Asp Phe Ala His Asn Leu Val Lys 
        515                 520                 525             


Asp Leu Arg Ala Ser Asp Thr Arg Val Asp Ile Thr Phe Pro Asp Pro 
    530                 535                 540                 


Pro Phe Asn Phe Ser Ala Val Val Pro Glu Arg Glu Gln Glu Val Arg 
545                 550                 555                 560 


Trp Phe Val His Gly Lys Val Met Lys Gln Leu Glu Ile Cys Glu Arg 
                565                 570                 575     


Leu Gly Ser Gln Gly Asp Ala Ala Val Ile Ala Ala Ala Ala Ala Ala 
            580                 585                 590         


Thr Ala Arg Gly Lys Ala Asn Val Thr Leu Asn Thr Ser Gly Val Lys 
        595                 600                 605             


Ala Asn Asp Thr Gly Val Gly Pro Asn Thr Thr Asn Thr Ala Gly Gly 
    610                 615                 620                 


Ala Asn Thr Thr Ala Asn Val Val Ala Asn Gly Thr Ala Asn Val Ile 
625                 630                 635                 640 


Val Asn Pro Ser Thr Asn Ala Thr Pro Thr Gly Thr Ser Asn Ala Ser 
                645                 650                 655     


Val Thr Asn Thr Thr Glu Arg Ala Val Pro Val Val Ala Pro Thr Gln 
            660                 665                 670         


Pro Ser Asn Gly Tyr Ala Glu Cys Arg Ser Ala Ile Thr Asn Arg Thr 
        675                 680                 685             


Glu Thr Gln Asn Met Glu Pro Pro Tyr Asp Arg Lys His Arg Tyr Glu 
    690                 695                 700                 


Val Phe Leu Pro Lys Lys Tyr Asp Phe Asn Val Ser Trp Cys Val Asp 
705                 710                 715                 720 


Ile Ile Asp Trp Arg Asp Leu Asp Glu Met Leu Asn Asn Arg Thr Asp 
                725                 730                 735     


Glu Val Val Glu Lys Ser Leu Ser Trp Cys Gly His Gly Cys Ile Ile 
            740                 745                 750         


Ala Phe Ala Val Val Gly Ser Leu Ile Ala Ala Cys Leu Val Val Leu 
        755                 760                 765             


Ala Val Val Leu Thr Ser Lys Arg Arg Arg Leu Ala Ala Val Val Ala 
    770                 775                 780                 


Pro Pro Arg Pro Lys Phe Val Ser Thr Val Glu Asp Asp Glu Glu Asp 
785                 790                 795                 800 


Arg Val Ser Asn Ile Gly Val Pro Leu Thr Asp Gly Lys Gly Thr Thr 
                805                 810                 815     


Ala Pro 
        


<210>  10
<211>  818
<212>  PRT
<213>  Trypanosoma brucei

<400>  10

Met Cys Phe Ile Phe Gly Val Glu Met Ser Asn Leu Ala Lys Arg Pro 
1               5                   10                  15      


Met Ser Leu Arg Lys Leu Pro Gln Leu Phe Leu Leu Ile Met Ile Gly 
            20                  25                  30          


Ile Ala Phe Val Ala Val Glu Cys Ile Gly Ala Pro Val Lys Leu Pro 
        35                  40                  45              


Arg Arg Val Asp Thr Val Ala Gly Gln Phe Gly Val Glu Gly Glu Thr 
    50                  55                  60                  


Asn Gly Tyr Pro Asn Thr Thr Arg Leu Thr Glu Pro Tyr Ala Leu Cys 
65                  70                  75                  80  


Arg Gly Arg Thr Asn Asp Glu Ile Leu Val Gly Ser Ser Asn Ser Phe 
                85                  90                  95      


Arg Asn Tyr Ser Arg Lys Thr Lys Glu Thr Gly Thr Phe Leu Arg Gly 
            100                 105                 110         


Gly Pro Thr Gly Gly Leu Val Ser Ala Asp Ala Lys Ile Ser Lys Pro 
        115                 120                 125             


Arg Ser Cys Val Arg Arg Gly Ser Gly Asn His Thr Ile Ile Tyr Phe 
    130                 135                 140                 


Val Asp Asp Gln Asn Gly Leu Lys Tyr Ile Asn Asp Asn Glu Ile Gln 
145                 150                 155                 160 


His Val Thr Val Gly Asp Gly Leu Ser Leu Thr Ser Val Ala Ile Tyr 
                165                 170                 175     


Glu Lys Asp Leu Tyr Val Thr Asp Gln Asn Asn Lys Ser Val Trp Arg 
            180                 185                 190         


Cys Asn Val Gly Gly Ala Gly Lys Pro Gln Asn Cys Glu Glu Lys Lys 
        195                 200                 205             


Phe Thr Gly Leu Thr Phe Thr Ala Lys Pro Glu Gly Ile Ala Val Thr 
    210                 215                 220                 


Ser Lys Gly Ile Phe Val Ala Ala Arg Asp Ser Ser Asn Lys Gly Ala 
225                 230                 235                 240 


Leu Leu Trp Leu Asp Met Asn Gly Ser Asn Arg Lys Gly Asn Val Ser 
                245                 250                 255     


Gly Gly Phe Val Asp Val Phe Ser Thr Glu Ser Gly Met Leu Tyr Ala 
            260                 265                 270         


Ala Thr Glu Lys Glu Leu Tyr Thr Val Thr Ala Thr Asp Ser Ala Phe 
        275                 280                 285             


Ser Val Thr Leu Phe Ala Gly Lys Asn Thr Ser Ser Cys Tyr Ser His 
    290                 295                 300                 


Ala Asn Gly Glu Asp Ile Val Leu Cys Asp Asn Ser Arg Leu Leu Val 
305                 310                 315                 320 


Ile Glu Glu Tyr Glu Met Tyr Val Thr Ser Met Glu Lys His Thr Met 
                325                 330                 335     


Arg Ala Leu Thr Leu Pro Pro Val Asn Leu Thr Ala Ile Phe Arg Gly 
            340                 345                 350         


Arg Pro Ala Pro Val Gly Tyr Pro Asn Thr Thr Ile Met Glu Gln Phe 
        355                 360                 365             


Val Ala Ser Leu Thr Glu Asp Val Asn Lys Ala Leu Gly Thr Asn Asp 
    370                 375                 380                 


Ser Tyr Val Asp Pro Asp Ser Val Arg Val Asp Pro Asp Thr Trp Glu 
385                 390                 395                 400 


Thr Asn Phe Thr Val Phe Val Gln Gln Thr Arg Phe Asp Asn Thr Thr 
                405                 410                 415     


Glu Glu Lys Leu Arg Ser Leu Thr Tyr Thr Gln Thr Asp Lys Thr Val 
            420                 425                 430         


Asp Glu Tyr Tyr Gly Leu Thr Asp Glu Tyr Val Tyr Ile Asp Thr Val 
        435                 440                 445             


Leu Val Pro Phe Cys Asp Asp Ala Ser Leu Val Thr Ile Gln Arg Ala 
    450                 455                 460                 


Leu Ala Arg Glu Ala Gly Arg Ala Leu Asn Phe Ser Leu Ile Tyr Ala 
465                 470                 475                 480 


Asp Lys Pro Ile Thr Phe Gly Ser Asp Val Ala Glu Asn Val Thr Ala 
                485                 490                 495     


Val Lys Leu Leu Met Pro His Ser Phe Lys Asn Ala Thr Thr Pro Lys 
            500                 505                 510         


Gln Leu Ser Ala Ala Asn Leu Thr Asp Phe Ala His Asn Leu Val Lys 
        515                 520                 525             


Asp Leu Arg Ala Ser Asp Thr Arg Val Asp Ile Thr Phe Pro Asp Pro 
    530                 535                 540                 


Pro Phe Asn Phe Ser Ala Val Val Pro Glu Arg Glu Gln Glu Val Arg 
545                 550                 555                 560 


Trp Phe Val His Gly Lys Val Met Lys Gln Leu Glu Ile Cys Glu Arg 
                565                 570                 575     


Leu Gly Ser Gln Gly Asp Ala Ala Val Ile Ala Ala Ala Ala Ala Val 
            580                 585                 590         


Thr Ala Arg Gly Lys Ala Asn Val Thr Leu Asn Thr Ser Gly Val Lys 
        595                 600                 605             


Ala Asn Asp Thr Gly Val Gly Pro Asn Thr Thr Asn Thr Ala Gly Gly 
    610                 615                 620                 


Ala Asn Thr Thr Ala Asn Val Val Ala Asn Gly Thr Ala Asn Val Ile 
625                 630                 635                 640 


Val Asn Pro Ser Thr Asn Ala Thr Pro Thr Gly Thr Ser Asn Ala Ser 
                645                 650                 655     


Ala Thr Asn Thr Thr Glu Arg Ala Val Pro Val Val Ala Pro Thr Gln 
            660                 665                 670         


Pro Ser Asn Gly Tyr Ala Glu Cys Arg Ser Ala Ile Thr Asn Arg Thr 
        675                 680                 685             


Glu Thr Gln Asn Met Glu Pro Pro Tyr Asp Arg Lys His Arg Tyr Glu 
    690                 695                 700                 


Val Phe Leu Pro Lys Lys Tyr Asp Phe Asn Val Ser Trp Cys Val Asp 
705                 710                 715                 720 


Ile Ile Asp Trp Arg Asp Leu Asp Glu Met Leu Asn Asn Arg Thr Asp 
                725                 730                 735     


Glu Val Val Glu Lys Ser Leu Ser Trp Cys Gly His Gly Cys Ile Ile 
            740                 745                 750         


Ala Phe Ala Val Val Gly Ser Leu Ile Ala Ala Cys Leu Val Val Leu 
        755                 760                 765             


Ala Val Val Leu Thr Ser Lys Arg Arg Arg Leu Ala Ala Val Val Ala 
    770                 775                 780                 


Pro Pro Arg Pro Lys Phe Val Ser Thr Val Glu Asp Asp Glu Glu Asp 
785                 790                 795                 800 


Arg Val Ser Asn Ile Gly Val Pro Leu Thr Asp Gly Lys Gly Thr Thr 
                805                 810                 815     


Ala Pro 
        


<210>  11
<211>  810
<212>  PRT
<213>  Trypanosoma brucei

<400>  11

Met Cys Phe Ile Phe Gly Val Glu Met Ser Asn Leu Ala Lys Arg Pro 
1               5                   10                  15      


Met Ser Leu Arg Lys Leu Pro Gln Leu Phe Leu Leu Ile Met Ile Gly 
            20                  25                  30          


Ile Ala Phe Val Ala Val Glu Cys Ile Gly Ala Pro Val Lys Leu Pro 
        35                  40                  45              


Arg Arg Val Asp Thr Val Ala Gly Gln Phe Gly Val Glu Gly Glu Thr 
    50                  55                  60                  


Asn Gly Tyr Pro Asn Thr Thr Arg Leu Thr Glu Pro Tyr Ala Leu Cys 
65                  70                  75                  80  


Arg Gly Arg Thr Asn Asp Glu Ile Leu Val Gly Ser Ser Asn Ser Phe 
                85                  90                  95      


Arg Asn Tyr Ser Arg Lys Thr Lys Glu Thr Gly Thr Phe Leu Arg Gly 
            100                 105                 110         


Gly Pro Thr Gly Gly Leu Val Ser Ala Asp Ala Lys Ile Ser Lys Pro 
        115                 120                 125             


Arg Ser Cys Val Arg Arg Gly Ser Gly Asn His Thr Ile Ile Tyr Phe 
    130                 135                 140                 


Val Asp Asp Gln Asn Gly Leu Lys Tyr Ile Asn Asp Asn Glu Ile Gln 
145                 150                 155                 160 


His Val Thr Val Gly Asp Gly Leu Ser Leu Thr Ser Val Ala Ile Tyr 
                165                 170                 175     


Glu Lys Asp Leu Tyr Val Thr Asp Gln Asn Asn Lys Ser Val Trp Arg 
            180                 185                 190         


Cys Asn Val Gly Gly Ala Gly Lys Pro Gln Asn Cys Glu Glu Lys Lys 
        195                 200                 205             


Phe Thr Gly Leu Thr Phe Thr Ala Lys Pro Glu Gly Ile Ala Val Thr 
    210                 215                 220                 


Ser Lys Gly Ile Phe Val Ala Ala Arg Asp Ser Ser Asn Lys Gly Ala 
225                 230                 235                 240 


Leu Leu Trp Leu Asp Met Asn Gly Ser Asn Arg Lys Gly Asn Val Ser 
                245                 250                 255     


Gly Gly Phe Val Asp Val Phe Ser Thr Glu Ser Gly Met Leu Tyr Ala 
            260                 265                 270         


Ala Thr Glu Lys Glu Leu Tyr Thr Val Thr Ala Thr Asp Ser Ala Phe 
        275                 280                 285             


Ser Val Thr Leu Phe Ala Gly Lys Asn Thr Ser Ser Cys Tyr Ser His 
    290                 295                 300                 


Ala Asn Gly Glu Asp Ile Val Leu Cys Asp Asn Ser Arg Leu Leu Val 
305                 310                 315                 320 


Ile Glu Glu Tyr Glu Met Tyr Val Thr Ser Lys Glu Lys His Thr Met 
                325                 330                 335     


Arg Ala Leu Thr Leu Pro Pro Val Asn Leu Thr Ala Ile Phe Arg Gly 
            340                 345                 350         


Arg Pro Ala Pro Val Gly Tyr Pro Asn Thr Thr Ile Met Glu Gln Phe 
        355                 360                 365             


Val Ala Ser Leu Thr Glu Asp Val Asn Lys Ala Leu Gly Thr Asn Asp 
    370                 375                 380                 


Ser Tyr Val Asp Pro Asp Ser Val Arg Val Asp Pro Asp Thr Trp Glu 
385                 390                 395                 400 


Thr Asn Tyr Thr Val Phe Val Gln Gln Thr Arg Phe Asp Asn Thr Thr 
                405                 410                 415     


Glu Glu Lys Leu Arg Ser Leu Thr Tyr Thr Gln Thr Asp Lys Thr Val 
            420                 425                 430         


Asp Glu Tyr Tyr Gly Leu Thr Asp Glu Tyr Val Tyr Ile Asp Thr Val 
        435                 440                 445             


Leu Val Pro Phe Cys Asp Asp Ala Ser Leu Val Thr Ile Gln Arg Ala 
    450                 455                 460                 


Leu Ala Arg Glu Ala Gly Arg Ala Leu Asn Phe Ser Leu Ile Tyr Ala 
465                 470                 475                 480 


Asp Lys Pro Ile Thr Phe Gly Ser Asp Val Ala Glu Asn Val Thr Ala 
                485                 490                 495     


Val Lys Leu Leu Met Pro His Ser Phe Lys Asn Ala Thr Thr Pro Lys 
            500                 505                 510         


Gln Leu Ser Ala Ala Asn Leu Thr Asp Phe Ala His Asn Leu Val Lys 
        515                 520                 525             


Asp Leu Arg Ala Ser Asp Thr Arg Val Asp Ile Thr Phe Pro Asp Pro 
    530                 535                 540                 


Pro Phe Asn Phe Ser Ala Val Val Pro Glu Arg Glu Gln Glu Val Arg 
545                 550                 555                 560 


Trp Phe Val His Gly Lys Val Met Lys Gln Leu Glu Ile Cys Glu Arg 
                565                 570                 575     


Leu Gly Ser Gln Gly Asp Ala Ala Val Ile Ala Ala Ala Ala Asp Ala 
            580                 585                 590         


Thr Ala Arg Gly Lys Ala Asn Val Thr Leu Asn Thr Ser Gly Val Lys 
        595                 600                 605             


Ala Asn Asp Thr Gly Val Gly Pro Asn Thr Thr Asn Thr Ala Gly Gly 
    610                 615                 620                 


Ala Asn Thr Thr Ala Asn Val Ala Thr Asn Gly Thr Ala Asn Val Ile 
625                 630                 635                 640 


Val Asn Pro Ser Thr Asn Ala Ser Val Thr Asn Thr Thr Glu Arg Ala 
                645                 650                 655     


Val Pro Val Val Ala Pro Thr Gln Pro Ser Asn Gly Tyr Ala Glu Cys 
            660                 665                 670         


Arg Ser Ala Ile Thr Asn Arg Thr Glu Thr Gln Asn Met Glu Pro Pro 
        675                 680                 685             


Tyr Asp Arg Lys His Arg Tyr Glu Val Phe Leu Pro Lys Lys Tyr Asp 
    690                 695                 700                 


Phe Asn Val Ser Trp Cys Val Asp Ile Ile Asp Trp Arg Asp Leu Asp 
705                 710                 715                 720 


Glu Met Leu Asn Asn Arg Thr Asp Glu Val Val Glu Lys Ser Leu Ser 
                725                 730                 735     


Trp Cys Gly His Gly Cys Ile Ile Ala Phe Ala Val Val Gly Ser Leu 
            740                 745                 750         


Ile Ala Ala Cys Leu Val Val Leu Ala Val Val Leu Thr Ser Lys Arg 
        755                 760                 765             


Arg Arg Leu Ala Ala Val Val Ala Pro Pro Arg Pro Lys Phe Val Ser 
    770                 775                 780                 


Thr Val Glu Asp Asp Glu Glu Asp Arg Val Ser Asn Ile Gly Val Pro 
785                 790                 795                 800 


Leu Thr Asp Gly Lys Gly Thr Thr Ala Pro 
                805                 810 


<210>  12
<211>  750
<212>  PRT
<213>  Trypanosoma brucei

<400>  12

Met Pro Leu Trp Lys Gln Thr Asn Cys Glu Val Glu Thr Met Asn Val 
1               5                   10                  15      


Arg Glu Val Val Gly Thr Val His Leu Gly Tyr Val Ser Gln Met Leu 
            20                  25                  30          


Leu Leu Val Ala Thr Val Ala Thr Ile Val Val Arg Ser Gly Ala Ala 
        35                  40                  45              


Pro Ile Glu Leu Lys Arg His Val Thr Thr Val Ala Gly Lys Tyr Gly 
    50                  55                  60                  


His Ile Gly Asp Lys Asp Gly Phe Pro Gly Met Ser Glu Leu Ser Ser 
65                  70                  75                  80  


Pro His Ala Met Cys Arg Gly Arg Asn Ser Asp Glu Ile Leu Leu Gly 
                85                  90                  95      


Thr Val Asp Arg Phe Arg Ala Phe Ser Arg Lys Asn Arg Glu Thr Thr 
            100                 105                 110         


Thr Ile Thr Ala Trp Glu Thr Asp Glu Asp Gln Lys Ser Gly Ser Arg 
        115                 120                 125             


Ser Val Lys Val Asp Lys Pro Arg Ala Cys Val Gln Trp Thr Val Gly 
    130                 135                 140                 


Gly Ser Thr Phe Val Tyr Phe Val Glu Ser Met Gly Glu Val Lys Tyr 
145                 150                 155                 160 


Phe Lys Asp Ser Gly Val Phe Ser His Asp Val Val Arg Asn Gly Ser 
                165                 170                 175     


Leu Thr Gly Val Ala Leu Tyr Gly Asn His Leu Tyr Leu Thr Glu Gln 
            180                 185                 190         


Asn Thr Asn Thr Val Trp Thr Cys Glu Val Gly Ser Asp Gly Asp Pro 
        195                 200                 205             


Ile Ala Cys His Ser His Val Ala Leu Ser Ala Asn Cys Ser Ile Tyr 
    210                 215                 220                 


Gly Pro Ile Gly Ile Ala Ala Thr Gln Gln Gly Ile Phe Val Val Ala 
225                 230                 235                 240 


Arg Gly Pro Ala Lys Gln Gly Thr Ile Cys Trp Phe Asp Leu Gln Gly 
                245                 250                 255     


His Lys Ile Ala Glu Val Asp Gly Glu Tyr Val Asp Ile Thr Ser Thr 
            260                 265                 270         


Arg Ser Gly Asp Leu Leu Ala Ala Thr Gln Asn Glu Leu His Arg Val 
        275                 280                 285             


Ser Thr Asp Gly Asn Lys Leu Thr Thr Lys Arg Phe Ala Gly Gly Ser 
    290                 295                 300                 


Thr Asn Ser Cys Leu Pro Asn Thr Glu Gly Asp Asp Thr Leu Leu Cys 
305                 310                 315                 320 


Glu Ile Thr Arg Leu Leu Val Val Thr Glu Tyr Glu Met Tyr Val Thr 
                325                 330                 335     


Ser Glu Lys Lys Ser Val Leu Arg Ser Val Thr Leu Pro Pro Val Tyr 
            340                 345                 350         


Val Gln Gly Leu Phe Pro Gly Arg Pro Leu Pro Val Gly Tyr Pro Asp 
        355                 360                 365             


Lys Asp Ile Met Glu Trp Ile Val Gly Asn Leu Thr Glu Asp Ile Asn 
    370                 375                 380                 


Thr Ala Leu Gly Thr Thr Glu Ser Ile Val Ala Ser Ser Ser Val His 
385                 390                 395                 400 


Val Asp Ser Thr Thr Trp Leu Thr Asn Phe Thr Ala Gly Val Gln Gln 
                405                 410                 415     


Pro Asp Phe Asp Asp Glu Lys Thr Glu Gln Ala Leu His Lys Ser Asn 
            420                 425                 430         


Tyr Glu His Thr Lys Glu Ala Ala Asp Glu Tyr Tyr Asn Leu Thr Asp 
        435                 440                 445             


Glu Gln Val Tyr Met Asp Ser Thr Met Val Pro Tyr Cys Asn Arg Leu 
    450                 455                 460                 


Ser Leu Asp Ala Leu Arg Arg Lys Leu Ala Lys Glu Ala Gly Glu Val 
465                 470                 475                 480 


Leu Asn Phe Thr Leu Ile Tyr Ala Asp Met Pro Leu Lys Ala Glu Ser 
                485                 490                 495     


Ser Asp Ala Glu Asn Ile Thr Thr Val Lys Leu Leu Met Pro Ala Ser 
            500                 505                 510         


Phe Asn Asn Thr Val Thr His Asp Leu Leu Ser Asp Ala Asn Leu Thr 
        515                 520                 525             


Glu Thr Ala His Ser Phe Ile Lys Tyr Leu Arg Ser Ser Asp Thr His 
    530                 535                 540                 


Val Asp Val Thr Phe Ser Asn Pro Pro Phe Asn Phe Ser Ser Leu Thr 
545                 550                 555                 560 


Pro Asp Glu Glu Gln Glu Val Arg Trp Tyr Ile His Asp Glu Val Met 
                565                 570                 575     


Asn Gln Ile Lys Lys Cys Glu Glu Arg Ser Thr Gly Arg Ser Met Ala 
            580                 585                 590         


Arg Arg Glu Glu Val Gly Asp His Ser Arg Thr Thr Ile Ala Thr Ala 
        595                 600                 605             


Leu Asp Ser Asn Val Thr Gly Val Cys Gln Ser Thr Ile Thr Asn Arg 
    610                 615                 620                 


Thr Val Ser Leu Phe Tyr Gln Pro Pro Tyr Val Glu Met Ser Leu Tyr 
625                 630                 635                 640 


Glu Val Phe Ile Pro Gly Asn Tyr Thr Phe Asp Val Ser Glu Cys Val 
                645                 650                 655     


Gly Glu Ile Asp Trp Gln Asp Leu Asn Asp His Leu Asn Asn Asp Thr 
            660                 665                 670         


Val Arg Pro Thr Thr Glu Lys Ala Pro Lys Cys Gly Arg Val Cys Leu 
        675                 680                 685             


Ile Ile Ile Ala Val Val Cys Ala Leu Ile Val Ala Val Leu Ile Val 
    690                 695                 700                 


Leu Ala Val Val Phe Thr Ser Lys Arg Arg Arg Leu Ala Ala Val Val 
705                 710                 715                 720 


Ala Pro Ala Arg Pro Lys Phe Val Ser Thr Leu Asp Glu Asp Glu Gln 
                725                 730                 735     


Asp Tyr Ala Ser Ala Tyr Gly Asn Lys Glu Arg Val Glu Gln 
            740                 745                 750 


<210>  13
<211>  750
<212>  PRT
<213>  Trypanosoma brucei

<400>  13

Met Pro Leu Trp Lys Gln Thr Asn Cys Glu Val Glu Thr Met Asn Val 
1               5                   10                  15      


Arg Glu Val Val Gly Thr Val His Leu Gly Tyr Val Ser Gln Met Leu 
            20                  25                  30          


Leu Leu Val Ala Thr Val Glu Thr Ile Val Val Arg Ser Gly Ala Ala 
        35                  40                  45              


Pro Ile Glu Leu Lys Arg His Val Thr Thr Val Ala Gly Lys Tyr Gly 
    50                  55                  60                  


His Ile Gly Asp Lys Asp Gly Phe Pro Gly Met Ser Glu Leu Ser Ser 
65                  70                  75                  80  


Pro His Ala Met Cys Arg Gly Arg Asn Ser Asp Glu Ile Leu Leu Gly 
                85                  90                  95      


Thr Val Asp Arg Phe Arg Ala Phe Ser Arg Lys Asn Arg Glu Thr Thr 
            100                 105                 110         


Thr Ile Thr Ala Trp Glu Thr Asp Glu Asp Gln Asn Ser Gly Ser Arg 
        115                 120                 125             


Ser Val Lys Val Asp Lys Pro Arg Ala Cys Val Gln Trp Thr Val Gly 
    130                 135                 140                 


Asp Ser Thr Phe Val Tyr Phe Val Glu Ser Met Gly Glu Val Lys Tyr 
145                 150                 155                 160 


Phe Lys Asp Ser Gly Val Phe Ser His Asp Val Val Arg Asn Gly Ser 
                165                 170                 175     


Leu Thr Gly Val Ala Leu Tyr Gly Asn His Leu Tyr Leu Thr Glu Gln 
            180                 185                 190         


Asn Thr Asn Thr Val Trp Thr Cys Glu Val Gly Ser Asp Gly Asp Pro 
        195                 200                 205             


Ile Ala Cys His Ser His Val Ala Leu Ser Ala Lys Cys Ser Ile Tyr 
    210                 215                 220                 


Gly Pro Ile Gly Ile Ala Ala Thr Gln Gln Gly Ile Phe Val Val Ala 
225                 230                 235                 240 


Arg Gly Pro Ala Lys Gln Gly Thr Ile Cys Trp Phe Asp Leu Gln Gly 
                245                 250                 255     


His Lys Ile Ala Glu Val Asp Gly Glu Tyr Val Asp Ile Thr Ser Thr 
            260                 265                 270         


Arg Ser Gly Asp Leu Leu Ala Ala Thr Gln Asn Glu Leu His Arg Val 
        275                 280                 285             


Ser Thr Asp Gly Asn Lys Leu Thr Thr Lys Arg Phe Ala Gly Gly Ser 
    290                 295                 300                 


Thr Asn Ser Cys Leu Pro Asn Thr Glu Gly Asp Asp Thr Leu Leu Cys 
305                 310                 315                 320 


Glu Ile Thr Arg Leu Leu Val Val Thr Glu Tyr Glu Met Tyr Val Thr 
                325                 330                 335     


Ser Glu Lys Lys Ser Val Leu Arg Ser Val Thr Leu Pro Pro Val Tyr 
            340                 345                 350         


Val Gln Gly Val Phe Pro Gly Arg Pro Leu Pro Val Gly Tyr Pro Asp 
        355                 360                 365             


Lys Asp Ile Met Glu Trp Ile Val Gly Asn Leu Thr Glu Asp Ile Asn 
    370                 375                 380                 


Thr Ala Leu Gly Thr Thr Glu Ser Ile Val Ala Ser Ser Ser Val His 
385                 390                 395                 400 


Val Asp Ser Thr Thr Trp Leu Thr Asn Phe Thr Ala Gly Val Gln Gln 
                405                 410                 415     


Pro Asp Phe Asp Asp Glu Lys Thr Glu Gln Ala Leu His Lys Ser Asn 
            420                 425                 430         


Tyr Glu His Thr Lys Glu Ala Ala Asp Glu Tyr Tyr Asn Leu Thr Asp 
        435                 440                 445             


Glu Gln Val Tyr Met Asp Ser Thr Met Val Pro Tyr Cys Asn Arg Leu 
    450                 455                 460                 


Ser Leu Asp Ala Leu Arg Arg Lys Leu Ala Lys Glu Ala Gly Glu Val 
465                 470                 475                 480 


Leu Asn Phe Thr Leu Ile Tyr Ala Asp Met Pro Leu Lys Ala Glu Ser 
                485                 490                 495     


Ser Asp Ala Gly Asn Ile Thr Thr Val Lys Leu Leu Met Pro Ala Ser 
            500                 505                 510         


Phe Asn Asn Thr Val Thr His Asp Leu Leu Ser Asp Ala Asn Leu Thr 
        515                 520                 525             


Glu Thr Ala His Ser Phe Ile Lys Tyr Leu Arg Ser Ser Asp Thr His 
    530                 535                 540                 


Val Asp Val Thr Phe Ser Asn Pro Pro Phe Asn Phe Ser Ser Leu Thr 
545                 550                 555                 560 


Pro Asp Glu Glu Gln Glu Val Arg Trp Tyr Ile His Asp Glu Val Met 
                565                 570                 575     


Asn Gln Ile Lys Lys Cys Glu Glu Arg Ser Thr Gly Arg Ser Met Ala 
            580                 585                 590         


Arg Arg Glu Glu Val Gly Asp Tyr Ser Arg Thr Thr Ile Ala Thr Ala 
        595                 600                 605             


Leu Asp Ser Asn Val Thr Gly Val Cys Gln Ser Thr Ile Thr Asn Arg 
    610                 615                 620                 


Thr Val Ser Leu Phe Tyr Gln Pro Pro Tyr Val Glu Met Ser Leu Tyr 
625                 630                 635                 640 


Glu Val Phe Ile Pro Gly Asn Tyr Thr Phe Asp Val Ser Glu Cys Val 
                645                 650                 655     


Gly Glu Ile Asp Trp Gln Asp Leu Asn Asp His Leu Asn Asn Asp Thr 
            660                 665                 670         


Val Arg Pro Thr Thr Glu Lys Ala Pro Lys Cys Gly Arg Val Cys Leu 
        675                 680                 685             


Ile Ile Ile Ala Val Val Cys Ala Leu Ile Val Ala Val Leu Ile Val 
    690                 695                 700                 


Leu Ala Val Val Phe Thr Ser Lys Arg Arg Arg Leu Ala Ala Val Val 
705                 710                 715                 720 


Ala Pro Ala Arg Pro Lys Phe Val Ser Thr Leu Asp Glu Asp Glu Gln 
                725                 730                 735     


Asp Tyr Ala Ser Ala Tyr Gly Asn Lys Glu Arg Val Glu Gln 
            740                 745                 750 


<210>  14
<211>  818
<212>  PRT
<213>  Trypanosoma brucei

<400>  14

Met Cys Phe Ile Phe Gly Val Glu Met Ser Asn Leu Ala Lys Arg Pro 
1               5                   10                  15      


Met Ser Leu Arg Lys Leu Pro Gln Leu Leu Leu Leu Ile Met Ile Gly 
            20                  25                  30          


Ile Ala Phe Val Ala Val Glu Cys Ile Gly Ala Pro Val Lys Leu Pro 
        35                  40                  45              


Arg Arg Val Asp Thr Val Ala Gly Gln Phe Gly Val Glu Gly Glu Thr 
    50                  55                  60                  


Asn Gly Tyr Pro Asn Thr Thr Arg Leu Thr Glu Pro Tyr Ala Leu Cys 
65                  70                  75                  80  


Arg Gly Arg Thr Asn Asp Glu Ile Leu Val Gly Ser Ser Asn Ser Phe 
                85                  90                  95      


Arg Asn Tyr Ser Arg Lys Thr Lys Glu Thr Gly Thr Tyr Leu Arg Tyr 
            100                 105                 110         


Asn Val Gly Asp Ser Val Ile Ser Gly Ser Ser Thr Ile Asn Lys Pro 
        115                 120                 125             


Arg Ser Cys Val Arg Arg Gly Ser Gly Asn His Thr Ile Ile Tyr Phe 
    130                 135                 140                 


Val Asp Asp Gln Lys Asp Ile Lys Tyr Ile Val Gly Asp Asp Val Ser 
145                 150                 155                 160 


Ser Phe Ser Val Pro Thr Ser Gly Ser Leu Asn Ala Val Ala Val His 
                165                 170                 175     


Glu Gly Thr Leu Tyr Val Thr Asp Gln Asn Asn Lys Ser Val Trp Lys 
            180                 185                 190         


Cys Gly Leu Gly Gly Ala Gly Lys Pro Gln Ser Cys Glu Glu Lys Lys 
        195                 200                 205             


Phe Thr Ser Val Thr Leu Asp Ala Lys Pro Glu Gly Ile Ala Val Thr 
    210                 215                 220                 


Ser Lys Gly Ile Phe Val Thr Ala Arg Asp Ser Ser Asn Lys Gly Ala 
225                 230                 235                 240 


Leu Leu Trp Leu Asp Met Ser Gly Gly Asn Arg Lys Gly Asn Val Ser 
                245                 250                 255     


Gly Gly Phe Val Asp Val Phe Ser Thr Glu Ser Gly Val Leu Tyr Ala 
            260                 265                 270         


Ala Thr Glu Lys Glu Leu Tyr Thr Val Thr Ala Thr Asp Thr Ser Leu 
        275                 280                 285             


Ser Val Thr Ser Phe Ala Gly Lys Asn Thr Ser Gln Cys Tyr Phe Pro 
    290                 295                 300                 


Thr Asn Gly Glu Asp Ile Val Leu Cys Asp Asn Ser Arg Leu Leu Val 
305                 310                 315                 320 


Ile Glu Glu Tyr Glu Met Tyr Val Thr Ser Lys Ala Lys His Thr Met 
                325                 330                 335     


Arg Ala Leu Thr Leu Pro Pro Val Asn Leu Thr Ala Ile Phe Arg Gly 
            340                 345                 350         


Arg Pro Ala Pro Val Gly Tyr Pro Asn Thr Thr Ile Met Glu Gln Phe 
        355                 360                 365             


Val Ala Ser Leu Thr Glu Asp Val Asn Lys Ala Leu Gly Thr Asn Asp 
    370                 375                 380                 


Ser Tyr Val Asp Pro Asp Ser Val Arg Val Asp Pro Asp Thr Trp Glu 
385                 390                 395                 400 


Thr Asn Phe Thr Val Phe Val Gln Gln Thr Arg Phe Asp Asn Thr Thr 
                405                 410                 415     


Glu Glu Lys Leu Arg Ser Leu Thr Tyr Thr Gln Thr Asp Lys Thr Val 
            420                 425                 430         


Asp Glu Tyr Tyr Gly Leu Thr Asp Glu Tyr Val Tyr Ile Asp Thr Val 
        435                 440                 445             


Leu Val Pro Phe Cys Asp Asp Ala Ser Leu Val Thr Ile Gln Arg Ala 
    450                 455                 460                 


Leu Ala Arg Glu Ala Gly Arg Ala Leu Asn Phe Ser Leu Val Tyr Ala 
465                 470                 475                 480 


Asp Lys Pro Ile Thr Phe Gly Ser Asp Val Ala Glu Asn Val Thr Ala 
                485                 490                 495     


Val Lys Leu Leu Met Pro His Ser Phe Lys Asn Ala Thr Thr Pro Lys 
            500                 505                 510         


Gln Leu Ser Ala Ala Asn Leu Thr Asp Phe Ala His Asn Leu Val Lys 
        515                 520                 525             


Asp Leu Arg Ala Ser Asp Thr Arg Val Asp Ile Thr Phe Pro Asp Pro 
    530                 535                 540                 


Pro Phe Asn Phe Ser Ala Val Val Pro Glu Arg Glu Gln Glu Val Arg 
545                 550                 555                 560 


Trp Phe Val His Gly Lys Val Met Lys Gln Leu Glu Ile Cys Glu Arg 
                565                 570                 575     


Leu Gly Ser Gln Gly Asp Ala Ala Val Ile Ala Ala Ala Ala Asp Ala 
            580                 585                 590         


Thr Ala Arg Gly Lys Ala Asn Val Thr Leu Asn Thr Ser Gly Val Lys 
        595                 600                 605             


Ala Asn Asp Thr Gly Val Gly Pro Asn Thr Thr Asn Thr Ala Gly Gly 
    610                 615                 620                 


Ala Asn Thr Thr Ala Asn Val Ala Ala Asn Gly Thr Ala Asn Val Ile 
625                 630                 635                 640 


Val Asn Pro Ser Thr Asn Ala Thr Pro Thr Gly Thr Thr Asn Ala Ser 
                645                 650                 655     


Val Thr Asn Thr Thr Glu Arg Ala Val Pro Val Val Ala Pro Thr Gln 
            660                 665                 670         


Pro Ser Asn Gly Tyr Ala Glu Cys Arg Ser Ala Ile Thr Asn Arg Thr 
        675                 680                 685             


Glu Thr Gln Asn Met Glu Pro Pro Tyr Asp Arg Lys His Arg Tyr Glu 
    690                 695                 700                 


Val Phe Leu Pro Lys Lys Tyr Asp Phe Asn Val Ser Trp Cys Val Asp 
705                 710                 715                 720 


Ile Ile Asp Trp Arg Asp Leu Asp Glu Met Leu Asn Asn Arg Thr Asp 
                725                 730                 735     


Glu Val Val Glu Lys Ser Leu Ser Trp Cys Gly His Gly Cys Ile Ile 
            740                 745                 750         


Ala Phe Ala Val Val Gly Ser Leu Ile Ala Ala Cys Leu Val Val Leu 
        755                 760                 765             


Ala Val Val Leu Thr Ser Lys Arg Arg Arg Leu Ala Ala Val Val Ala 
    770                 775                 780                 


Pro Pro Arg Pro Lys Phe Val Ser Thr Val Glu Asp Asp Asp Glu Asp 
785                 790                 795                 800 


Arg Val Ser Asn Ile Gly Val Pro Leu Thr Asp Gly Lys Gly Thr Thr 
                805                 810                 815     


Ala Pro 
        


<210>  15
<211>  818
<212>  PRT
<213>  Trypanosoma brucei

<400>  15

Met Cys Phe Ile Phe Gly Val Glu Met Ser Asn Leu Ala Lys Arg Pro 
1               5                   10                  15      


Met Ser Leu Arg Lys Leu Pro Gln Leu Leu Leu Leu Ile Met Ile Gly 
            20                  25                  30          


Ile Ala Phe Val Ala Val Glu Cys Ile Gly Ala Pro Val Lys Leu Pro 
        35                  40                  45              


Arg Arg Val Asp Thr Val Ala Gly Gln Phe Gly Phe Asp Gly Thr Thr 
    50                  55                  60                  


Asp Gly Ser Ser Asn Val Ser Met Leu Ser Ser Pro Tyr Ala Leu Cys 
65                  70                  75                  80  


Arg Gly Arg Thr Asn Asp Glu Ile Leu Val Gly Ser Ser Asn Ser Phe 
                85                  90                  95      


Arg Asn Tyr Ser Arg Lys Thr Lys Glu Thr Gly Thr Phe Leu Arg Gly 
            100                 105                 110         


Gly Pro Thr Gly Gly Leu Val Ser Ala Asp Ala Lys Ile Ser Lys Pro 
        115                 120                 125             


Arg Ser Cys Val Arg Arg Gly Ser Gly Asn His Thr Ile Ile Tyr Phe 
    130                 135                 140                 


Val Asp Asp Gln Asn Gly Leu Lys Tyr Ile Asn Asp Asn Glu Ile Gln 
145                 150                 155                 160 


His Val Thr Val Gly Asn Gly Leu Ser Leu Thr Ser Val Ala Ile Tyr 
                165                 170                 175     


Glu Lys Asp Leu Tyr Val Thr Asp Gln Asn Asn Lys Ser Val Trp Arg 
            180                 185                 190         


Cys Asn Val Gly Gly Ala Gly Lys Pro Gln Asn Cys Glu Glu Lys Lys 
        195                 200                 205             


Phe Thr Gly Leu Thr Phe Thr Ala Lys Pro Glu Gly Ile Ala Val Thr 
    210                 215                 220                 


Ser Lys Gly Ile Phe Val Ala Ala Arg Asp Ser Ser Asn Lys Gly Ala 
225                 230                 235                 240 


Leu Leu Trp Leu Asp Met Asn Gly Gly Gly Ser Lys Gly Asn Val Ser 
                245                 250                 255     


Gly Gly Phe Val Asp Val Phe Ser Thr Glu Ser Gly Met Leu Tyr Ala 
            260                 265                 270         


Ala Thr Glu Lys Glu Leu Tyr Thr Val Thr Ala Thr Gly Ser Ala Phe 
        275                 280                 285             


Ser Val Thr Ser Phe Ala Gly Lys Asn Thr Ser Ser Cys Tyr Ser His 
    290                 295                 300                 


Ala Asn Gly Glu Asp Ile Val Leu Cys Asp Asn Ser Arg Leu Leu Val 
305                 310                 315                 320 


Ile Glu Glu Tyr Glu Met Tyr Val Thr Ser Lys Glu Lys His Thr Met 
                325                 330                 335     


Arg Ala Leu Thr Leu Pro Pro Val Asn Leu Thr Ala Ile Phe Arg Gly 
            340                 345                 350         


Arg Pro Ala Pro Val Gly Tyr Pro Asn Thr Thr Ile Met Glu Gln Phe 
        355                 360                 365             


Val Ala Ser Leu Thr Glu Asp Val Asn Lys Ala Leu Gly Thr Asn Asp 
    370                 375                 380                 


Ser Tyr Val Asp Pro Asp Ser Val Arg Val Asp Pro Asp Thr Trp Glu 
385                 390                 395                 400 


Thr Asn Phe Thr Val Phe Val Gln Gln Thr Arg Phe Asp Asn Thr Thr 
                405                 410                 415     


Glu Glu Lys Leu Arg Ser Leu Thr Tyr Thr Gln Thr Asp Lys Thr Val 
            420                 425                 430         


Asp Glu Tyr Tyr Gly Leu Thr Asp Glu Tyr Val Tyr Ile Asp Thr Val 
        435                 440                 445             


Leu Val Pro Phe Cys Asp Asp Ala Ser Leu Val Thr Ile Gln Arg Ala 
    450                 455                 460                 


Leu Ala Arg Glu Ala Gly Arg Ala Leu Asn Phe Ser Leu Ile Tyr Ala 
465                 470                 475                 480 


Asp Lys Pro Ile Thr Phe Gly Ser Asp Val Ala Glu Asn Val Thr Ala 
                485                 490                 495     


Val Lys Leu Leu Met Pro His Ser Phe Lys Asn Ala Thr Thr Pro Lys 
            500                 505                 510         


Gln Leu Ser Ala Ala Asn Leu Thr Asp Phe Ala His Asn Leu Val Lys 
        515                 520                 525             


Asp Leu Arg Ala Ser Asp Thr Arg Val Asp Ile Thr Phe Pro Asp Pro 
    530                 535                 540                 


Pro Phe Asn Phe Ser Ala Val Val Pro Glu Arg Glu Gln Glu Val Arg 
545                 550                 555                 560 


Trp Phe Val His Gly Lys Val Met Lys Gln Leu Glu Ile Cys Glu Arg 
                565                 570                 575     


Leu Gly Ser Gln Gly Asp Ala Ala Val Ile Ala Ala Ala Ala Ala Ala 
            580                 585                 590         


Thr Ala Arg Gly Lys Ala Asn Val Thr Leu Asn Thr Ser Gly Val Lys 
        595                 600                 605             


Ala Asn Asp Thr Gly Val Gly Pro Asn Thr Thr Asn Thr Ala Gly Gly 
    610                 615                 620                 


Ala Asn Thr Thr Ala Asn Val Val Ala Asn Gly Thr Ala Asn Val Ile 
625                 630                 635                 640 


Val Asn Pro Ser Thr Asn Ala Thr Pro Thr Gly Thr Thr Asn Ala Ser 
                645                 650                 655     


Val Thr Asn Thr Thr Glu Arg Ala Val Pro Val Val Ala Pro Thr Gln 
            660                 665                 670         


Pro Ser Asn Gly Tyr Ala Glu Cys Arg Ser Ala Ile Thr Asn Arg Thr 
        675                 680                 685             


Glu Thr Gln Asn Met Glu Pro Pro Tyr Asp Arg Lys His Arg Tyr Glu 
    690                 695                 700                 


Val Phe Leu Pro Lys Lys Tyr Asp Phe Asn Val Ser Trp Cys Val Asp 
705                 710                 715                 720 


Ile Ile Asp Trp Arg Asp Leu Asp Glu Met Leu Asn Asn Arg Thr Asp 
                725                 730                 735     


Glu Val Val Glu Lys Ser Leu Ser Trp Cys Gly His Gly Cys Ile Ile 
            740                 745                 750         


Ala Phe Ala Val Val Gly Ser Leu Ile Ala Ala Cys Leu Val Val Leu 
        755                 760                 765             


Ala Val Val Leu Thr Ser Lys Arg Arg Arg Leu Ala Ala Val Val Ala 
    770                 775                 780                 


Pro Pro Arg Pro Lys Phe Val Ser Thr Val Glu Asp Asp Glu Glu Asp 
785                 790                 795                 800 


Arg Val Ser Asn Ile Gly Val Pro Leu Thr Asp Gly Lys Gly Thr Thr 
                805                 810                 815     


Ala Pro 
        


<210>  16
<211>  750
<212>  PRT
<213>  Trypanosoma brucei

<400>  16

Met Pro Leu Trp Lys Gln Thr Asn Cys Glu Val Glu Thr Met Asn Val 
1               5                   10                  15      


Arg Glu Val Val Gly Thr Val His Leu Gly Tyr Val Ser Gln Met Leu 
            20                  25                  30          


Leu Leu Val Ala Thr Val Ala Thr Ile Val Val Arg Ser Gly Ala Ala 
        35                  40                  45              


Pro Ile Glu Leu Lys Arg His Val Thr Thr Val Ala Gly Lys Tyr Gly 
    50                  55                  60                  


His Ile Gly Asp Lys Asp Gly Phe Pro Gly Met Ser Glu Leu Ser Ser 
65                  70                  75                  80  


Pro His Ala Met Cys Arg Gly Arg Asn Ser Asp Glu Ile Leu Leu Gly 
                85                  90                  95      


Thr Val Asp Arg Phe Arg Ala Phe Ser Arg Lys Asn Arg Glu Thr Thr 
            100                 105                 110         


Thr Ile Thr Ala Trp Glu Thr Asp Glu Asp Gln Lys Ser Gly Ser Arg 
        115                 120                 125             


Ser Val Lys Val Asp Lys Pro Arg Ala Cys Val Gln Trp Thr Val Gly 
    130                 135                 140                 


Gly Ser Thr Phe Val Tyr Phe Val Glu Ser Met Gly Glu Val Lys Tyr 
145                 150                 155                 160 


Phe Lys Asp Ser Gly Val Phe Ser His Asp Val Val Arg Asn Gly Ser 
                165                 170                 175     


Leu Thr Gly Val Ala Leu Tyr Gly Asn His Leu Tyr Leu Thr Glu Gln 
            180                 185                 190         


Asn Thr Asn Thr Val Trp Thr Cys Glu Val Gly Ser Asp Gly Asp Pro 
        195                 200                 205             


Ile Ala Cys His Ser His Val Ala Leu Ser Ala Asn Cys Ser Ile Tyr 
    210                 215                 220                 


Gly Pro Ile Gly Ile Ala Ala Thr Gln Gln Gly Ile Phe Val Val Ala 
225                 230                 235                 240 


Arg Gly Pro Ala Lys Gln Gly Thr Ile Cys Trp Phe Asp Leu Gln Gly 
                245                 250                 255     


His Lys Ile Ala Glu Val Asp Gly Glu Tyr Val Asp Ile Thr Ser Thr 
            260                 265                 270         


Arg Ser Gly Asp Leu Leu Ala Ala Thr Gln Asn Glu Leu His Arg Val 
        275                 280                 285             


Ser Thr Asp Gly Asn Lys Leu Thr Thr Lys Arg Phe Ala Gly Gly Ser 
    290                 295                 300                 


Thr Asn Ser Cys Leu Pro Asn Thr Glu Gly Asp Asp Thr Leu Leu Cys 
305                 310                 315                 320 


Glu Ile Thr Arg Leu Leu Val Val Thr Glu Tyr Glu Met Tyr Val Thr 
                325                 330                 335     


Ser Glu Lys Lys Ser Val Leu Arg Ser Val Thr Leu Pro Pro Val Tyr 
            340                 345                 350         


Val Gln Gly Leu Phe Pro Gly Arg Pro Leu Pro Val Gly Tyr Pro Asp 
        355                 360                 365             


Lys Asp Ile Met Glu Trp Ile Val Gly Asn Leu Thr Glu Asp Ile Asn 
    370                 375                 380                 


Thr Ala Leu Gly Thr Thr Glu Ser Ile Val Ala Ser Ser Ser Val His 
385                 390                 395                 400 


Val Asp Ser Thr Thr Trp Leu Thr Asn Phe Thr Ala Gly Val Gln Gln 
                405                 410                 415     


Pro Asp Phe Asp Asp Glu Lys Thr Glu Gln Ala Leu His Glu Ser Asn 
            420                 425                 430         


Tyr Glu His Thr Lys Glu Ala Ala Asp Glu Tyr Tyr Asn Leu Thr Asp 
        435                 440                 445             


Glu Gln Val Tyr Met Asp Ser Thr Met Val Pro Tyr Cys Asn Arg Leu 
    450                 455                 460                 


Ser Leu Asp Ala Leu Arg Arg Lys Leu Ala Lys Glu Ala Gly Glu Val 
465                 470                 475                 480 


Leu Asn Phe Thr Leu Ile Tyr Ala Asp Met Pro Leu Lys Ala Glu Ser 
                485                 490                 495     


Ser Asp Ala Glu Asn Ile Thr Thr Val Lys Leu Leu Met Pro Ala Ser 
            500                 505                 510         


Phe Asn Asn Thr Val Thr His Asp Leu Leu Ser Asp Ala Asn Leu Thr 
        515                 520                 525             


Glu Thr Ala His Ser Phe Ile Lys Tyr Leu Arg Ser Ser Asp Thr His 
    530                 535                 540                 


Val Asp Val Thr Phe Ser Asn Pro Pro Phe Asn Phe Ser Ser Leu Thr 
545                 550                 555                 560 


Pro Asp Glu Glu Gln Glu Val Arg Trp Tyr Ile His Asp Glu Val Met 
                565                 570                 575     


Asn Gln Ile Lys Lys Cys Glu Glu Arg Ser Thr Gly Arg Ser Met Ala 
            580                 585                 590         


Arg Arg Glu Glu Val Gly Asp His Ser Arg Thr Thr Ile Ala Thr Ala 
        595                 600                 605             


Leu Asp Ser Asn Val Thr Gly Val Cys Gln Ser Thr Ile Thr Asn Arg 
    610                 615                 620                 


Thr Val Ser Leu Phe Tyr Gln Pro Pro Tyr Val Glu Met Ser Leu Tyr 
625                 630                 635                 640 


Glu Val Phe Ile Pro Gly Asn Tyr Thr Phe Asp Val Ser Glu Cys Val 
                645                 650                 655     


Gly Glu Ile Asp Trp Gln Asp Leu Asn Asp His Leu Asn Asn Asp Thr 
            660                 665                 670         


Val Arg Pro Thr Thr Glu Lys Ala Pro Lys Cys Gly Arg Val Cys Leu 
        675                 680                 685             


Ile Ile Ile Ala Val Val Cys Ala Leu Ile Val Ala Val Leu Ile Val 
    690                 695                 700                 


Leu Ala Val Val Phe Thr Ser Lys Arg Arg Arg Leu Ala Ala Val Val 
705                 710                 715                 720 


Ala Pro Ala Arg Pro Lys Phe Val Ser Thr Leu Asp Glu Asp Glu Gln 
                725                 730                 735     


Asp Tyr Ala Ser Ala Tyr Gly Asn Lys Glu Arg Val Glu Gln 
            740                 745                 750 


<210>  17
<211>  750
<212>  PRT
<213>  Trypanosoma brucei

<400>  17

Met Pro Leu Trp Lys Gln Thr Asn Cys Glu Val Glu Thr Met Asn Val 
1               5                   10                  15      


Arg Glu Val Val Gly Thr Val His Leu Gly Tyr Val Ser Gln Met Leu 
            20                  25                  30          


Leu Leu Val Ala Thr Val Ala Thr Ile Val Val Arg Ser Gly Ala Ala 
        35                  40                  45              


Pro Ile Glu Leu Lys Arg His Val Thr Thr Val Ala Gly Lys Tyr Gly 
    50                  55                  60                  


His Ile Gly Asp Lys Asp Gly Phe Pro Gly Met Ser Glu Leu Ser Ser 
65                  70                  75                  80  


Pro His Ala Met Cys Arg Gly Arg Asn Ser Asp Glu Ile Leu Leu Gly 
                85                  90                  95      


Thr Val Asp Arg Phe Arg Ala Phe Ser Arg Lys Asn Arg Glu Thr Thr 
            100                 105                 110         


Thr Ile Thr Ala Trp Glu Thr Asp Glu Asp Gln Lys Ser Gly Ser Arg 
        115                 120                 125             


Ser Val Lys Val Asp Lys Pro Arg Ala Cys Val Gln Trp Thr Val Gly 
    130                 135                 140                 


Gly Ser Thr Phe Val Tyr Phe Val Glu Ser Met Gly Glu Val Lys Tyr 
145                 150                 155                 160 


Phe Lys Asp Ser Gly Val Phe Ser His Asp Val Val Arg Asn Gly Ser 
                165                 170                 175     


Leu Thr Gly Val Ala Leu Tyr Gly Asn His Leu Tyr Leu Thr Glu Gln 
            180                 185                 190         


Asn Thr Asn Thr Val Trp Thr Cys Glu Val Gly Ser Asp Gly Asp Pro 
        195                 200                 205             


Ile Ala Cys His Ser His Val Ala Leu Ser Ala Asn Cys Ser Ile Tyr 
    210                 215                 220                 


Gly Pro Ile Gly Ile Ala Ala Thr Gln Gln Gly Ile Phe Val Val Ala 
225                 230                 235                 240 


Arg Gly Pro Ala Lys Gln Gly Thr Ile Cys Trp Phe Asp Leu Gln Gly 
                245                 250                 255     


His Lys Ile Ala Glu Val Asp Gly Glu Tyr Val Asp Ile Thr Ser Thr 
            260                 265                 270         


Arg Ser Gly Asp Leu Leu Ala Ala Thr Gln Asn Glu Leu His Arg Val 
        275                 280                 285             


Ser Thr Asp Gly Asn Lys Leu Thr Thr Lys Arg Phe Ala Gly Gly Ser 
    290                 295                 300                 


Thr Asn Ser Cys Leu Pro Asn Thr Glu Gly Asp Asp Thr Leu Leu Cys 
305                 310                 315                 320 


Glu Ile Thr Arg Leu Leu Val Val Thr Glu Tyr Glu Met Tyr Val Thr 
                325                 330                 335     


Ser Glu Lys Lys Ser Val Leu Arg Ser Val Thr Leu Pro Pro Val Tyr 
            340                 345                 350         


Val Gln Gly Leu Phe Pro Gly Arg Pro Leu Pro Val Gly Tyr Pro Asp 
        355                 360                 365             


Lys Asp Ile Met Glu Trp Ile Val Gly Asn Leu Thr Glu Asp Ile Asn 
    370                 375                 380                 


Thr Ala Leu Gly Thr Thr Glu Ser Ile Val Ala Ser Ser Ser Val His 
385                 390                 395                 400 


Val Asp Ser Thr Thr Trp Leu Thr Asn Phe Thr Ala Gly Val Gln Gln 
                405                 410                 415     


Pro Asp Phe Asp Asp Glu Lys Thr Glu Gln Ala Leu His Glu Ser Asn 
            420                 425                 430         


Tyr Glu His Thr Lys Glu Ala Ala Asp Glu Tyr Tyr Asn Leu Thr Asp 
        435                 440                 445             


Glu Gln Val Tyr Met Asp Ser Thr Met Val Pro Tyr Cys Asn Arg Leu 
    450                 455                 460                 


Ser Leu Asp Ala Leu Arg Arg Lys Leu Ala Lys Glu Ala Gly Glu Val 
465                 470                 475                 480 


Leu Asn Phe Thr Leu Ile Tyr Ala Asp Met Pro Leu Lys Ala Glu Ser 
                485                 490                 495     


Ser Asp Ala Glu Asn Ile Thr Thr Val Lys Leu Leu Met Pro Ala Ser 
            500                 505                 510         


Phe Asn Asn Thr Val Thr His Asp Leu Leu Ser Asp Ala Asn Leu Thr 
        515                 520                 525             


Glu Thr Ala His Ser Phe Ile Lys Tyr Leu Arg Ser Ser Asp Thr His 
    530                 535                 540                 


Val Asp Val Thr Phe Ser Asn Pro Pro Phe Asn Phe Ser Ser Leu Thr 
545                 550                 555                 560 


Pro Asp Glu Glu Gln Glu Val Arg Trp Tyr Ile His Asp Glu Val Met 
                565                 570                 575     


Asn Gln Ile Lys Lys Cys Glu Glu Arg Ser Thr Gly Arg Ser Met Ala 
            580                 585                 590         


Arg Arg Glu Glu Val Gly Asp His Ser Arg Thr Thr Ile Ala Thr Ala 
        595                 600                 605             


Leu Asp Ser Asn Val Thr Gly Val Cys Gln Ser Thr Ile Thr Asn Arg 
    610                 615                 620                 


Thr Val Ser Leu Phe Tyr Gln Pro Pro Tyr Val Glu Met Ser Leu Tyr 
625                 630                 635                 640 


Glu Val Phe Ile Pro Gly Asn Tyr Thr Phe Asp Val Ser Glu Cys Val 
                645                 650                 655     


Gly Glu Ile Asp Trp Gln Asp Leu Asn Asp His Leu Asn Asn Asp Thr 
            660                 665                 670         


Val Arg Pro Thr Thr Glu Lys Ala Pro Lys Cys Gly Arg Val Cys Leu 
        675                 680                 685             


Ile Ile Ile Ala Val Val Cys Ala Leu Ile Val Ala Val Leu Ile Val 
    690                 695                 700                 


Leu Ala Val Val Phe Thr Ser Lys Arg Arg Arg Leu Ala Ala Val Val 
705                 710                 715                 720 


Ala Pro Ala Arg Pro Lys Phe Val Ser Thr Leu Asp Glu Asp Glu Gln 
                725                 730                 735     


Asp Tyr Ala Ser Ala Tyr Gly Asn Lys Glu Arg Val Glu Gln 
            740                 745                 750 


<210>  18
<211>  818
<212>  PRT
<213>  Trypanosoma brucei

<400>  18

Met Cys Phe Ile Phe Gly Val Glu Met Ser Asn Leu Ala Lys Arg Pro 
1               5                   10                  15      


Met Ser Leu Arg Lys Leu Pro Gln Leu Leu Leu Leu Ile Met Ile Gly 
            20                  25                  30          


Ile Ala Phe Val Ala Val Glu Cys Ile Gly Ala Pro Val Lys Leu Pro 
        35                  40                  45              


Arg Arg Val Asp Thr Val Ala Gly Gln Phe Gly Val Glu Gly Glu Thr 
    50                  55                  60                  


Asn Gly Tyr Pro Asn Thr Thr Arg Leu Thr Glu Pro Tyr Ala Leu Cys 
65                  70                  75                  80  


Arg Gly Arg Thr Asn Asp Glu Ile Leu Val Gly Ser Ser Asn Ser Phe 
                85                  90                  95      


Arg Asn Tyr Ser Arg Lys Thr Lys Glu Thr Gly Thr Tyr Leu Arg Tyr 
            100                 105                 110         


Asn Val Gly Asp Ser Val Ile Ser Gly Ser Ser Thr Ile Asn Lys Pro 
        115                 120                 125             


Arg Ser Cys Val Arg Arg Gly Ser Gly Asn His Thr Ile Ile Tyr Phe 
    130                 135                 140                 


Val Asp Asp Gln Lys Asp Ile Lys Tyr Ile Val Gly Asp Asp Val Ser 
145                 150                 155                 160 


Ser Phe Ser Val Pro Thr Ser Gly Ser Leu Asn Ala Val Ala Val His 
                165                 170                 175     


Glu Gly Ser Leu Tyr Val Thr Asp Gln Asn Asn Lys Ser Val Trp Lys 
            180                 185                 190         


Cys Gly Leu Gly Gly Ala Gly Lys Pro Gln Ser Cys Glu Glu Lys Lys 
        195                 200                 205             


Phe Thr Ser Val Thr Leu Asp Ala Lys Pro Glu Gly Ile Ala Val Thr 
    210                 215                 220                 


Ser Lys Gly Ile Phe Val Thr Ala Arg Asp Ser Ser Asn Lys Gly Ala 
225                 230                 235                 240 


Leu Leu Trp Leu Asp Met Ser Gly Ser Asn Arg Lys Gly Asn Val Ser 
                245                 250                 255     


Gly Gly Phe Val Asp Val Phe Ser Thr Glu Ser Gly Val Leu Tyr Ala 
            260                 265                 270         


Ala Thr Glu Lys Glu Leu Tyr Thr Val Thr Ala Thr Asp Thr Ser Leu 
        275                 280                 285             


Ser Val Thr Leu Phe Ala Gly Lys Asn Thr Ser Gln Cys Tyr Phe Ser 
    290                 295                 300                 


Thr Asn Gly Glu Asp Ile Val Leu Cys Asp Asn Ser Arg Leu Leu Val 
305                 310                 315                 320 


Ile Glu Glu Tyr Glu Met Tyr Val Thr Ser Lys Glu Lys His Thr Met 
                325                 330                 335     


Arg Ala Leu Thr Leu Pro Pro Val Asn Leu Thr Ala Ile Phe Arg Gly 
            340                 345                 350         


Arg Pro Ala Pro Val Gly Tyr Pro Asn Thr Thr Ile Met Glu Gln Phe 
        355                 360                 365             


Val Ala Ser Leu Thr Glu Asp Val Asn Lys Ala Leu Gly Thr Asn Asp 
    370                 375                 380                 


Ser Tyr Val Asp Pro Asp Ser Val Arg Val Asp Pro Asn Thr Trp Glu 
385                 390                 395                 400 


Thr Asn Tyr Thr Val Phe Val Gln Gln Thr Arg Phe Asp Asn Thr Thr 
                405                 410                 415     


Glu Glu Lys Leu Arg Ser Leu Thr Tyr Thr Gln Thr Asp Lys Thr Val 
            420                 425                 430         


Asp Glu Tyr Tyr Gly Leu Thr Asp Glu Tyr Val Tyr Ile Asp Thr Val 
        435                 440                 445             


Leu Val Pro Phe Cys Asp Asp Ala Ser Leu Val Thr Ile Gln Arg Ala 
    450                 455                 460                 


Leu Ala Arg Glu Ala Gly Arg Ala Leu Asn Phe Ser Leu Ile Tyr Ala 
465                 470                 475                 480 


Asp Lys Pro Ile Thr Phe Gly Ser Asp Val Ala Glu Asn Val Thr Ala 
                485                 490                 495     


Val Lys Leu Leu Met Pro His Ser Phe Lys Asn Ala Thr Thr Pro Lys 
            500                 505                 510         


Gln Leu Ser Ala Ala Asn Leu Thr Asp Phe Ala His Asn Leu Val Lys 
        515                 520                 525             


Asp Leu Arg Ala Ser Asp Thr Arg Val Asp Ile Thr Phe Pro Asp Pro 
    530                 535                 540                 


Pro Phe Asn Phe Ser Ala Val Val Pro Glu Arg Glu Gln Glu Val Arg 
545                 550                 555                 560 


Trp Phe Val His Gly Lys Val Met Lys Gln Leu Glu Ile Cys Glu Arg 
                565                 570                 575     


Leu Gly Ser Gln Gly Asp Ala Ala Val Ile Ala Ala Ala Ala Asp Ala 
            580                 585                 590         


Thr Ala Arg Gly Lys Ala Asn Val Thr Leu Asn Thr Ser Gly Val Lys 
        595                 600                 605             


Ala Asn Asp Thr Gly Val Gly Pro Asn Thr Thr Asn Thr Ala Gly Gly 
    610                 615                 620                 


Ala Asp Thr Thr Ala Asn Val Ala Ala Asn Gly Thr Ala Asn Val Ile 
625                 630                 635                 640 


Val Asn Pro Ser Thr Asn Ala Thr Pro Thr Gly Thr Thr Asn Ala Ser 
                645                 650                 655     


Val Thr Asn Thr Thr Glu Arg Ala Val Pro Val Val Ala Pro Thr Gln 
            660                 665                 670         


Pro Ser Asn Gly Tyr Ala Glu Cys Arg Ser Ala Ile Thr Asn Arg Thr 
        675                 680                 685             


Glu Thr Gln Asn Met Glu Pro Pro Tyr Asp Arg Lys His Arg Tyr Glu 
    690                 695                 700                 


Val Phe Leu Pro Lys Lys Tyr Asp Phe Asn Val Ser Trp Cys Val Asp 
705                 710                 715                 720 


Ile Ile Asp Trp Arg Asp Leu Asp Glu Met Leu Asn Asn Arg Thr Asp 
                725                 730                 735     


Glu Val Val Glu Lys Ser Leu Ser Trp Cys Gly His Gly Cys Ile Ile 
            740                 745                 750         


Ala Phe Ala Val Val Gly Ser Leu Ile Ala Ala Cys Leu Val Val Leu 
        755                 760                 765             


Ala Val Val Leu Thr Ser Lys Arg Arg Arg Leu Ala Ala Val Val Ala 
    770                 775                 780                 


Pro Pro Arg Pro Lys Phe Val Ser Thr Val Glu Asp Asp Glu Glu Asp 
785                 790                 795                 800 


Arg Val Ser Asn Ile Gly Val Pro Leu Thr Asp Gly Lys Gly Thr Thr 
                805                 810                 815     


Ala Pro 
        


<210>  19
<211>  818
<212>  PRT
<213>  Trypanosoma brucei

<400>  19

Met Cys Phe Ile Phe Gly Val Glu Met Ser Asn Leu Ala Lys Arg Pro 
1               5                   10                  15      


Met Ser Leu Arg Lys Leu Pro Gln Leu Leu Leu Leu Ile Met Ile Gly 
            20                  25                  30          


Ile Ala Phe Val Ala Val Glu Cys Ile Gly Ala Pro Val Lys Leu Pro 
        35                  40                  45              


Arg Arg Val Asp Thr Val Ala Gly Gln Phe Gly Phe Asp Gly Thr Thr 
    50                  55                  60                  


Asp Gly Ser Ser Asn Val Ser Met Leu Ser Ser Pro Tyr Ala Leu Cys 
65                  70                  75                  80  


Arg Gly Arg Thr Asn Asp Glu Ile Leu Val Gly Ser Ser Asn Ser Phe 
                85                  90                  95      


Arg Asn Tyr Ser Arg Lys Thr Lys Glu Thr Gly Thr Phe Leu Arg Gly 
            100                 105                 110         


Gly Pro Thr Gly Gly Leu Val Ser Ala Asp Ala Lys Ile Ser Lys Pro 
        115                 120                 125             


Arg Ser Cys Val Arg Arg Gly Ser Gly Asn His Thr Ile Ile Tyr Phe 
    130                 135                 140                 


Val Asp Asp Gln Asn Gly Leu Lys Tyr Ile Asn Asp Asn Glu Ile Gln 
145                 150                 155                 160 


His Val Thr Val Gly Asn Gly Leu Ser Leu Thr Ser Val Ala Ile Tyr 
                165                 170                 175     


Glu Lys Asp Leu Tyr Val Thr Asp Gln Asn Asn Lys Ser Val Trp Arg 
            180                 185                 190         


Cys Asn Val Gly Gly Ala Gly Lys Pro Gln Asn Cys Glu Glu Lys Lys 
        195                 200                 205             


Phe Thr Gly Leu Thr Phe Thr Ala Lys Pro Glu Gly Ile Ala Val Thr 
    210                 215                 220                 


Ser Lys Gly Ile Phe Val Ala Ala Arg Asp Ser Ser Asn Lys Gly Ala 
225                 230                 235                 240 


Leu Leu Trp Leu Asp Met Asn Gly Gly Gly Ser Lys Gly Asn Val Ser 
                245                 250                 255     


Gly Gly Phe Val Asp Val Phe Ser Thr Glu Ser Gly Met Leu Tyr Ala 
            260                 265                 270         


Ala Thr Glu Lys Glu Leu Tyr Thr Val Thr Ala Thr Asp Ser Ala Phe 
        275                 280                 285             


Ser Val Thr Ser Phe Ala Gly Lys Asn Thr Ser Ser Cys Tyr Ser His 
    290                 295                 300                 


Ala Asn Gly Glu Asp Ile Val Leu Cys Asp Asn Ser Arg Leu Leu Val 
305                 310                 315                 320 


Ile Glu Glu Tyr Glu Met Tyr Val Thr Ser Lys Glu Lys His Thr Met 
                325                 330                 335     


Arg Ala Leu Thr Leu Pro Pro Val Asn Leu Thr Ala Ile Phe Arg Gly 
            340                 345                 350         


Arg Pro Ala Pro Val Gly Tyr Pro Asn Thr Thr Ile Met Glu Gln Phe 
        355                 360                 365             


Val Ala Ser Leu Thr Glu Asp Val Asn Lys Ala Leu Gly Thr Asn Asp 
    370                 375                 380                 


Ser Tyr Val Asp Pro Asp Ser Val Arg Val Asp Pro Asp Thr Trp Glu 
385                 390                 395                 400 


Thr Asn Phe Thr Val Phe Val Gln Gln Thr Arg Phe Asp Asn Thr Thr 
                405                 410                 415     


Glu Glu Lys Leu Arg Ser Leu Thr Tyr Thr Gln Thr Asp Lys Thr Val 
            420                 425                 430         


Asp Glu Tyr Tyr Gly Leu Thr Asp Glu Tyr Val Tyr Ile Asp Thr Val 
        435                 440                 445             


Leu Val Pro Phe Cys Asp Asp Ala Ser Leu Val Thr Ile Gln Arg Ala 
    450                 455                 460                 


Leu Ala Arg Glu Ala Gly Arg Ala Leu Asn Phe Ser Leu Ile Tyr Ala 
465                 470                 475                 480 


Asp Lys Pro Ile Thr Phe Gly Ser Asp Val Ala Glu Asn Val Thr Ala 
                485                 490                 495     


Val Lys Leu Leu Met Pro His Ser Phe Lys Asn Ala Thr Thr Pro Lys 
            500                 505                 510         


Gln Leu Ser Ala Ala Asn Leu Thr Asp Phe Ala His Asn Leu Val Lys 
        515                 520                 525             


Asp Leu Arg Ala Ser Asp Thr Arg Val Asp Ile Thr Phe Pro Asp Pro 
    530                 535                 540                 


Pro Phe Asn Phe Ser Ala Val Val Pro Glu Arg Glu Gln Glu Val Arg 
545                 550                 555                 560 


Trp Phe Val His Gly Lys Val Met Lys Gln Leu Glu Ile Cys Glu Arg 
                565                 570                 575     


Leu Gly Ser Gln Gly Asp Ala Ala Val Ile Ala Ala Ala Ala Ala Ala 
            580                 585                 590         


Thr Ala Arg Gly Lys Ala Asn Val Thr Leu Asn Thr Ser Gly Val Lys 
        595                 600                 605             


Ala Asn Asp Thr Gly Val Gly Pro Asn Thr Thr Asn Thr Ala Gly Gly 
    610                 615                 620                 


Ala Asn Thr Thr Ala Asn Val Ala Ala Asn Gly Thr Ala Asn Val Ile 
625                 630                 635                 640 


Val Asn Pro Ser Thr Asn Ala Thr Pro Thr Gly Thr Thr Asn Ala Ser 
                645                 650                 655     


Val Thr Asn Thr Thr Glu Arg Ala Val Pro Val Val Ala Pro Thr Gln 
            660                 665                 670         


Pro Ser Asn Gly Tyr Ala Glu Cys Arg Ser Ala Ile Thr Asn Arg Thr 
        675                 680                 685             


Glu Thr Gln Asn Met Glu Pro Pro Tyr Asp Arg Lys His Arg Tyr Glu 
    690                 695                 700                 


Val Phe Leu Pro Lys Lys Tyr Asp Phe Asn Val Ser Trp Cys Val Asp 
705                 710                 715                 720 


Ile Ile Asp Trp Arg Asp Leu Asp Glu Met Leu Asn Asn Arg Thr Asp 
                725                 730                 735     


Glu Val Val Glu Lys Ser Leu Ser Trp Cys Gly His Gly Cys Ile Ile 
            740                 745                 750         


Ala Phe Ala Val Val Gly Ser Leu Ile Ala Ala Cys Leu Val Val Leu 
        755                 760                 765             


Ala Val Val Leu Thr Ser Lys Arg Arg Arg Leu Ala Ala Val Val Ala 
    770                 775                 780                 


Pro Pro Arg Pro Lys Phe Val Ser Thr Val Glu Asp Asp Glu Glu Asp 
785                 790                 795                 800 


Arg Val Ser Asn Ile Gly Val Pro Leu Thr Asp Gly Lys Gly Thr Thr 
                805                 810                 815     


Ala Pro 
        


<210>  20
<211>  820
<212>  PRT
<213>  Trypanosoma brucei

<400>  20

Leu Ala Met Cys Phe Ile Phe Gly Val Glu Met Ser Asn Leu Ala Lys 
1               5                   10                  15      


Arg Pro Met Ser Leu Arg Lys Leu Pro Gln Leu Leu Leu Leu Ile Met 
            20                  25                  30          


Ile Gly Ile Ala Phe Val Ala Val Glu Cys Ile Gly Ala Pro Val Lys 
        35                  40                  45              


Leu Pro Arg Arg Val Asp Thr Val Ala Gly Gln Phe Gly Phe Asp Gly 
    50                  55                  60                  


Thr Thr Asp Gly Ser Ser Asn Val Ser Met Leu Ser Ser Pro Tyr Ala 
65                  70                  75                  80  


Leu Cys Arg Gly Arg Thr Asn Asp Glu Ile Leu Val Gly Ser Ser Asn 
                85                  90                  95      


Ser Phe Arg Asn Tyr Ser Arg Lys Thr Lys Glu Thr Gly Thr Phe Leu 
            100                 105                 110         


Arg Gly Gly Pro Thr Gly Gly Leu Val Ser Ala Asp Ala Lys Ile Ser 
        115                 120                 125             


Lys Pro Arg Ser Cys Val Arg Arg Gly Ser Gly Asn His Thr Ile Ile 
    130                 135                 140                 


Tyr Phe Val Asp Asp Gln Asn Gly Leu Lys Tyr Ile Asn Asp Asn Glu 
145                 150                 155                 160 


Ile Gln His Val Thr Val Gly Asn Gly Leu Ser Leu Thr Ser Val Ala 
                165                 170                 175     


Ile Tyr Glu Lys Asp Leu Tyr Val Thr Asp Gln Asn Asn Lys Ser Val 
            180                 185                 190         


Trp Arg Cys Asn Val Gly Gly Ala Gly Lys Pro Gln Asn Cys Glu Glu 
        195                 200                 205             


Lys Lys Phe Thr Gly Leu Thr Phe Thr Ala Lys Pro Glu Gly Ile Ala 
    210                 215                 220                 


Val Thr Ser Lys Gly Ile Phe Val Ala Ala Arg Asp Ser Ser Asn Lys 
225                 230                 235                 240 


Gly Ala Leu Leu Trp Leu Asp Met Asn Gly Gly Gly Ser Lys Gly Asn 
                245                 250                 255     


Val Ser Gly Gly Phe Val Asp Val Phe Ser Thr Glu Ser Gly Met Leu 
            260                 265                 270         


Tyr Ala Ala Thr Glu Lys Glu Leu Tyr Thr Val Thr Ala Thr Gly Ser 
        275                 280                 285             


Ala Phe Ser Val Thr Ser Phe Ala Gly Lys Asn Thr Ser Ser Cys Tyr 
    290                 295                 300                 


Ser His Ala Asn Gly Glu Asp Ile Val Leu Cys Asp Asn Ser Arg Leu 
305                 310                 315                 320 


Leu Val Ile Glu Glu Tyr Glu Met Tyr Val Thr Ser Lys Glu Lys His 
                325                 330                 335     


Thr Met Arg Ala Leu Thr Leu Pro Pro Val Asn Leu Thr Ala Ile Phe 
            340                 345                 350         


Arg Gly Arg Pro Ala Pro Val Gly Tyr Pro Asn Thr Thr Ile Met Glu 
        355                 360                 365             


Gln Phe Val Ala Ser Leu Thr Glu Asp Val Asn Lys Ala Leu Gly Thr 
    370                 375                 380                 


Asn Asp Ser Tyr Val Asp Pro Asp Ser Val Arg Val Asp Pro Asp Thr 
385                 390                 395                 400 


Trp Glu Thr Asn Phe Thr Val Phe Val Gln Gln Thr Arg Phe Asp Asn 
                405                 410                 415     


Thr Thr Glu Glu Lys Leu Arg Ser Leu Thr Tyr Thr Gln Thr Asp Lys 
            420                 425                 430         


Thr Val Asp Glu Tyr Tyr Gly Leu Thr Asp Glu Tyr Val Tyr Ile Asp 
        435                 440                 445             


Thr Val Leu Val Pro Phe Cys Asp Asp Ala Ser Leu Val Thr Ile Gln 
    450                 455                 460                 


Arg Ala Leu Ala Arg Glu Ala Gly Arg Ala Leu Asn Phe Ser Leu Ile 
465                 470                 475                 480 


Tyr Ala Asp Lys Pro Ile Thr Phe Gly Ser Asp Val Ala Glu Asn Val 
                485                 490                 495     


Thr Ala Val Lys Leu Leu Met Pro His Ser Phe Lys Asn Ala Thr Thr 
            500                 505                 510         


Pro Lys Gln Leu Ser Ala Ala Asn Leu Thr Asp Phe Ala His Asn Leu 
        515                 520                 525             


Val Lys Asp Leu Arg Ala Ser Asp Thr Arg Val Asp Ile Thr Phe Pro 
    530                 535                 540                 


Asp Pro Pro Phe Asn Phe Ser Ala Val Val Pro Glu Arg Glu Gln Glu 
545                 550                 555                 560 


Val Arg Trp Phe Val His Gly Lys Val Met Lys Gln Leu Glu Ile Cys 
                565                 570                 575     


Glu Arg Leu Gly Ser Gln Gly Asp Ala Ala Val Ile Ala Ala Ala Ala 
            580                 585                 590         


Asp Ala Thr Ala Arg Gly Lys Ala Asn Val Thr Leu Asn Thr Ser Gly 
        595                 600                 605             


Val Lys Ala Asn Asp Thr Gly Val Gly Pro Asn Thr Thr Asn Thr Ala 
    610                 615                 620                 


Gly Gly Ala Asn Thr Thr Ala Asn Val Ala Ala Asn Gly Thr Ala Asn 
625                 630                 635                 640 


Val Ile Val Asn Pro Ser Thr Asn Ala Thr Pro Thr Gly Thr Thr Asn 
                645                 650                 655     


Ala Ser Val Thr Asn Thr Thr Glu Arg Ala Val Pro Val Val Ala Pro 
            660                 665                 670         


Thr Gln Pro Ser Asn Gly Tyr Ala Glu Cys Arg Ser Ala Ile Thr Asn 
        675                 680                 685             


Arg Thr Glu Thr Gln Asn Met Glu Pro Pro Tyr Asp Arg Lys His Arg 
    690                 695                 700                 


Tyr Glu Val Phe Leu Pro Lys Lys Tyr Asp Phe Asn Val Ser Trp Cys 
705                 710                 715                 720 


Val Asp Ile Ile Asp Trp Arg Asp Leu Asp Glu Met Leu Asn Asn Arg 
                725                 730                 735     


Thr Asp Glu Val Val Glu Lys Ser Leu Ser Trp Cys Gly His Gly Cys 
            740                 745                 750         


Ile Ile Ala Phe Ala Val Val Gly Ser Leu Ile Ala Ala Cys Leu Val 
        755                 760                 765             


Val Leu Ala Val Val Leu Thr Ser Lys Arg Arg Arg Leu Ala Ala Val 
    770                 775                 780                 


Val Ala Pro Pro Arg Pro Lys Phe Val Ser Thr Val Glu Asp Asp Glu 
785                 790                 795                 800 


Glu Asp Arg Val Ser Asn Ile Gly Val Pro Leu Thr Asp Gly Lys Gly 
                805                 810                 815     


Thr Thr Ala Pro 
            820 


<210>  21
<211>  573
<212>  PRT
<213>  Trypanosoma brucei gambiense

<400>  21

Met Ser Gly Ser Asn Arg Lys Gly Asn Val Ser Gly Gly Phe Val Asp 
1               5                   10                  15      


Val Phe Ser Thr Glu Ser Gly Met Leu Tyr Ala Ala Thr Glu Lys Glu 
            20                  25                  30          


Leu Tyr Thr Val Thr Ala Thr Asp Thr Ser Leu Ser Val Thr Leu Phe 
        35                  40                  45              


Ala Gly Lys Asn Thr Ser Ser Cys Tyr Ser His Ala Asn Gly Glu Asp 
    50                  55                  60                  


Ile Val Leu Cys Asp Asn Ser Arg Leu Leu Val Ile Glu Glu Tyr Glu 
65                  70                  75                  80  


Met Tyr Val Thr Ser Lys Glu Lys His Thr Met Arg Ala Leu Thr Leu 
                85                  90                  95      


Pro Pro Val Asn Leu Thr Ala Ile Phe Arg Gly Arg Pro Ala Pro Val 
            100                 105                 110         


Gly Tyr Pro Asn Thr Thr Ile Met Glu Gln Phe Val Ala Ser Leu Thr 
        115                 120                 125             


Glu Asp Val Asn Lys Ala Leu Gly Thr Asn Asp Ser Tyr Val Asp Pro 
    130                 135                 140                 


Asp Ser Val Arg Val Asp Pro Asp Thr Trp Glu Thr Asn Tyr Thr Val 
145                 150                 155                 160 


Phe Val Gln Gln Thr Arg Phe Asp Asn Thr Thr Glu Glu Lys Leu Arg 
                165                 170                 175     


Ser Leu Thr Tyr Thr Gln Thr Asp Lys Thr Val Asp Glu Tyr Tyr Gly 
            180                 185                 190         


Leu Thr Asp Glu Tyr Val Tyr Ile Asp Thr Val Leu Val Pro Phe Cys 
        195                 200                 205             


Asp Asp Ala Ser Leu Val Thr Ile Gln Arg Ala Leu Ala Arg Glu Ala 
    210                 215                 220                 


Gly Arg Ala Leu Asn Phe Ser Leu Ile Tyr Ala Asp Lys Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Ser Asp Val Ala Glu Asn Val Thr Ala Val Lys Leu Leu Met 
                245                 250                 255     


Pro His Ser Phe Lys Asn Ala Thr Thr Pro Lys Gln Leu Ser Ala Ala 
            260                 265                 270         


Asn Leu Thr Asp Phe Ala His Asn Leu Val Lys Asp Leu Arg Ala Ser 
        275                 280                 285             


Asp Thr Arg Val Asp Ile Thr Phe Pro Asp Pro Pro Phe Asn Phe Ser 
    290                 295                 300                 


Ala Val Val Pro Glu Arg Glu Gln Glu Val Arg Trp Phe Val His Gly 
305                 310                 315                 320 


Lys Val Met Lys Gln Leu Glu Ile Cys Glu Arg Leu Gly Ser Gln Gly 
                325                 330                 335     


Asp Ala Ala Val Ile Ala Ala Ala Ala Asp Ala Thr Ala Arg Gly Lys 
            340                 345                 350         


Ala Asn Val Thr Leu Asn Thr Ser Gly Val Lys Ala Asn Asp Thr Gly 
        355                 360                 365             


Val Gly Pro Asn Thr Thr Asn Thr Ala Gly Gly Ala Asn Thr Thr Ala 
    370                 375                 380                 


Asn Val Ala Thr Asn Gly Thr Ala Asn Val Ile Val Asn Pro Ser Thr 
385                 390                 395                 400 


Asn Ala Thr Pro Thr Gly Thr Ser Asn Ala Ser Ala Thr Asn Thr Thr 
                405                 410                 415     


Glu Arg Ala Val Pro Val Val Ala Pro Thr Gln Pro Ser Asn Gly Tyr 
            420                 425                 430         


Ala Glu Cys Arg Ser Ala Ile Thr Asn Arg Thr Glu Thr Gln Asn Met 
        435                 440                 445             


Glu Pro Pro Tyr Asp Arg Lys His Arg Tyr Glu Val Phe Leu Pro Lys 
    450                 455                 460                 


Lys Tyr Asp Phe Asn Val Ser Trp Cys Val Asp Ile Ile Asp Trp Arg 
465                 470                 475                 480 


Asp Leu Asp Glu Met Leu Asn Asn Arg Thr Asp Glu Val Val Glu Lys 
                485                 490                 495     


Ser Leu Ser Trp Cys Gly His Gly Cys Ile Ile Ala Phe Ala Val Val 
            500                 505                 510         


Gly Ser Leu Ile Ala Ala Cys Leu Val Val Leu Ala Val Val Leu Thr 
        515                 520                 525             


Ser Lys Arg Arg Arg Leu Ala Ala Val Val Ala Pro Pro Arg Pro Lys 
    530                 535                 540                 


Phe Val Ser Thr Val Glu Asp Asp Glu Glu Asp Arg Val Ser Asn Ile 
545                 550                 555                 560 


Gly Val Pro Leu Thr Asp Gly Lys Gly Thr Thr Ala Pro 
                565                 570             


<210>  22
<211>  818
<212>  PRT
<213>  Trypanosoma brucei gambiense

<400>  22

Met Cys Phe Ile Phe Gly Val Glu Met Ser Asn Leu Ala Lys Arg Pro 
1               5                   10                  15      


Met Ser Leu Arg Lys Leu Pro Gln Leu Phe Leu Leu Ile Met Ile Gly 
            20                  25                  30          


Ile Ala Phe Val Ala Val Glu Cys Ile Gly Ala Pro Val Lys Leu Pro 
        35                  40                  45              


Arg Arg Val Asp Thr Val Ala Gly Gln Phe Gly Phe Asp Gly Thr Thr 
    50                  55                  60                  


Asp Gly Ser Ser Asn Val Ser Met Leu Ser Ser Pro Tyr Ala Leu Cys 
65                  70                  75                  80  


Arg Gly Arg Thr Asn Asp Glu Ile Leu Val Gly Ser Ser Asn Ser Phe 
                85                  90                  95      


Arg Asn Tyr Ser Arg Lys Thr Lys Glu Thr Gly Thr Phe Leu Arg Gly 
            100                 105                 110         


Gly Pro Thr Gly Gly Leu Val Ser Ala Asp Ala Lys Ile Ser Lys Pro 
        115                 120                 125             


Arg Ser Cys Val Arg Arg Gly Ser Gly Asn His Thr Ile Ile Tyr Phe 
    130                 135                 140                 


Val Asp Asp Gln Asn Gly Leu Lys Tyr Ile Asn Asp Asn Glu Ile Gln 
145                 150                 155                 160 


His Val Thr Val Gly Asn Gly Leu Ser Leu Asn Ala Val Ala Ile His 
                165                 170                 175     


Glu Lys Asp Leu Tyr Val Thr Asp Gln Asn Asn Lys Ser Val Trp Arg 
            180                 185                 190         


Cys Asn Val Gly Gly Ala Gly Lys Pro Gln Asn Cys Glu Glu Lys Lys 
        195                 200                 205             


Phe Thr Gly Val Thr Phe Thr Ala Lys Pro Glu Gly Ile Ala Val Thr 
    210                 215                 220                 


Ser Lys Gly Ile Phe Val Thr Ala Arg Asp Ser Ser Asn Lys Gly Ala 
225                 230                 235                 240 


Leu Leu Trp Leu Asp Met Asn Gly Gly Gly Arg Lys Gly Asn Val Ser 
                245                 250                 255     


Gly Gly Phe Val Asp Val Phe Ser Thr Glu Ser Gly Val Leu Tyr Ala 
            260                 265                 270         


Ala Thr Glu Lys Glu Leu Tyr Thr Val Thr Ala Thr Asp Thr Ser Leu 
        275                 280                 285             


Ser Val Thr Leu Phe Ala Gly Lys Asn Thr Ser Gln Cys Tyr Phe Pro 
    290                 295                 300                 


Thr Asn Gly Glu Asp Ile Val Leu Cys Asp Asn Ser Arg Leu Leu Val 
305                 310                 315                 320 


Ile Glu Glu Tyr Glu Met Tyr Val Thr Ser Lys Ala Lys His Thr Met 
                325                 330                 335     


Arg Ala Leu Thr Leu Pro Pro Val Asn Leu Thr Ala Ile Phe Arg Gly 
            340                 345                 350         


Arg Pro Ala Pro Val Gly Tyr Pro Asn Thr Thr Ile Met Glu Gln Phe 
        355                 360                 365             


Val Ala Ser Leu Thr Glu Asp Val Asn Lys Ala Leu Gly Thr Asn Asp 
    370                 375                 380                 


Ser Tyr Val Asp Pro Asp Ser Val Arg Val Asp Pro Asp Thr Trp Glu 
385                 390                 395                 400 


Thr Asn Tyr Thr Val Phe Val Gln Gln Thr Arg Phe Asp Asn Thr Thr 
                405                 410                 415     


Glu Glu Lys Leu Arg Ser Leu Thr Tyr Thr Gln Thr Asp Lys Thr Val 
            420                 425                 430         


Asp Glu Tyr Tyr Gly Leu Thr Asp Glu Tyr Val Tyr Ile Asp Thr Val 
        435                 440                 445             


Leu Val Pro Phe Cys Asp Asp Ala Ser Leu Val Thr Ile Gln Arg Ala 
    450                 455                 460                 


Leu Ala Arg Glu Ala Gly Arg Ala Leu Asn Phe Ser Leu Ile Tyr Ala 
465                 470                 475                 480 


Asp Lys Pro Ile Thr Phe Gly Ser Asp Val Ala Glu Asn Val Thr Ala 
                485                 490                 495     


Val Lys Leu Leu Met Pro His Ser Phe Lys Asn Ala Thr Thr Pro Lys 
            500                 505                 510         


Gln Leu Ser Ala Ala Asn Leu Thr Asp Phe Ala His Asn Leu Val Lys 
        515                 520                 525             


Asp Leu Arg Ala Ser Asp Thr Arg Val Asp Ile Thr Phe Pro Asp Pro 
    530                 535                 540                 


Pro Phe Asn Phe Ser Ala Val Val Pro Glu Arg Glu Gln Glu Val Arg 
545                 550                 555                 560 


Trp Phe Val His Gly Lys Val Met Lys Gln Leu Glu Ile Cys Glu Arg 
                565                 570                 575     


Leu Gly Ser Gln Gly Asp Ala Ala Val Ile Ala Ala Ala Ala Asp Ala 
            580                 585                 590         


Thr Ala Arg Gly Lys Ala Asn Val Thr Leu Asn Thr Ser Gly Val Lys 
        595                 600                 605             


Ala Asn Asp Thr Gly Val Gly Pro Asn Thr Thr Asn Thr Ala Gly Gly 
    610                 615                 620                 


Ala Asn Thr Thr Ala Asn Val Ala Thr Asn Gly Thr Ala Asn Val Ile 
625                 630                 635                 640 


Val Asn Pro Ser Thr Asn Ala Thr Pro Thr Gly Thr Ser Asn Ala Ser 
                645                 650                 655     


Ala Thr Asn Thr Thr Glu Arg Ala Val Pro Val Val Ala Pro Thr Gln 
            660                 665                 670         


Pro Ser Asn Gly Tyr Ala Glu Cys Arg Ser Ala Ile Thr Asn Arg Thr 
        675                 680                 685             


Glu Thr Gln Asn Met Glu Pro Pro Tyr Asp Arg Lys His Arg Tyr Glu 
    690                 695                 700                 


Val Phe Leu Pro Lys Lys Tyr Asp Phe Asn Val Ser Trp Cys Val Asp 
705                 710                 715                 720 


Ile Ile Asp Trp Arg Asp Leu Asp Glu Met Leu Asn Asn Arg Thr Asp 
                725                 730                 735     


Glu Val Val Glu Lys Ser Leu Ser Trp Cys Gly His Gly Cys Ile Ile 
            740                 745                 750         


Ala Phe Ala Val Val Gly Ser Leu Ile Ala Ala Cys Leu Val Val Leu 
        755                 760                 765             


Ala Val Val Leu Thr Ser Lys Arg Arg Arg Leu Ala Ala Val Val Ala 
    770                 775                 780                 


Pro Pro Arg Pro Lys Phe Val Ser Thr Val Glu Asp Asp Glu Glu Asp 
785                 790                 795                 800 


Arg Val Ser Asn Ile Gly Val Pro Leu Thr Asp Gly Lys Gly Thr Thr 
                805                 810                 815     


Ala Pro 
        


<210>  23
<211>  750
<212>  PRT
<213>  Trypanosoma brucei gambiense

<400>  23

Met Pro Leu Trp Lys Gln Thr Asn Cys Glu Val Glu Thr Met Asn Val 
1               5                   10                  15      


Arg Glu Val Val Gly Thr Val His Leu Gly Tyr Val Ser Gln Met Leu 
            20                  25                  30          


Leu Leu Val Ala Thr Val Glu Thr Ile Val Val Arg Ser Gly Ala Ala 
        35                  40                  45              


Pro Ile Glu Leu Lys Arg His Val Thr Thr Val Ala Gly Lys Tyr Gly 
    50                  55                  60                  


His Ile Gly Asp Lys Asp Gly Phe Pro Gly Met Ser Glu Leu Ser Ser 
65                  70                  75                  80  


Pro His Ala Met Cys Arg Gly Arg Asn Ser Asp Glu Ile Leu Leu Gly 
                85                  90                  95      


Thr Val Asp Arg Phe Arg Ala Phe Ser Arg Lys Asn Arg Glu Thr Thr 
            100                 105                 110         


Thr Ile Thr Ala Trp Glu Thr Asp Glu Asp Gln Asn Ser Gly Ser Arg 
        115                 120                 125             


Ser Val Lys Val Asp Lys Pro Arg Ala Cys Val Gln Trp Thr Val Gly 
    130                 135                 140                 


Asp Ser Thr Phe Val Tyr Phe Val Glu Ser Met Gly Glu Val Lys Tyr 
145                 150                 155                 160 


Phe Lys Asp Ser Gly Val Phe Ser His Asp Val Val Arg Asn Gly Ser 
                165                 170                 175     


Leu Thr Gly Val Ala Leu Tyr Gly Asn His Leu Tyr Leu Thr Glu Gln 
            180                 185                 190         


Asn Thr Asn Thr Val Trp Thr Cys Glu Val Gly Ser Asp Gly Asp Pro 
        195                 200                 205             


Ile Ala Cys His Ser His Val Ala Leu Ser Ala Lys Cys Ser Ile Tyr 
    210                 215                 220                 


Gly Pro Ile Gly Ile Ala Ala Thr Gln Gln Gly Ile Phe Val Val Ala 
225                 230                 235                 240 


Arg Gly Pro Ala Lys Gln Gly Thr Ile Cys Trp Phe Asp Leu Gln Gly 
                245                 250                 255     


His Lys Ile Ala Glu Val Asp Gly Glu Tyr Val Asp Ile Thr Ser Thr 
            260                 265                 270         


Arg Ser Gly Asp Leu Leu Ala Ala Thr Gln Asn Glu Leu His Arg Val 
        275                 280                 285             


Ser Thr Asp Gly Asn Lys Leu Thr Thr Lys Arg Phe Ala Gly Gly Ser 
    290                 295                 300                 


Thr Asn Ser Cys Leu Pro Asn Thr Glu Gly Asp Asp Thr Leu Leu Cys 
305                 310                 315                 320 


Glu Ile Thr Arg Leu Leu Val Val Thr Glu Tyr Glu Met Tyr Val Thr 
                325                 330                 335     


Ser Glu Lys Lys Ser Val Leu Arg Ser Val Thr Leu Pro Pro Val Tyr 
            340                 345                 350         


Val Gln Gly Val Phe Pro Gly Arg Pro Leu Pro Val Gly Tyr Pro Asp 
        355                 360                 365             


Lys Asp Ile Met Glu Trp Ile Val Gly Asn Leu Thr Glu Asp Ile Asn 
    370                 375                 380                 


Thr Ala Leu Gly Thr Thr Glu Ser Ile Val Ala Ser Ser Ser Val His 
385                 390                 395                 400 


Val Asp Ser Thr Thr Trp Leu Thr Asn Phe Thr Ala Gly Val Gln Gln 
                405                 410                 415     


Pro Asp Phe Asp Asp Glu Lys Thr Glu Gln Ala Leu His Lys Ser Asn 
            420                 425                 430         


Tyr Glu His Thr Lys Glu Ala Ala Asp Glu Tyr Tyr Asn Leu Thr Asp 
        435                 440                 445             


Glu Gln Val Tyr Met Asp Ser Thr Met Val Pro Tyr Cys Asn Arg Leu 
    450                 455                 460                 


Ser Leu Asp Ala Leu Arg Arg Lys Leu Ala Lys Glu Ala Gly Glu Val 
465                 470                 475                 480 


Leu Asn Phe Thr Leu Ile Tyr Ala Asp Met Pro Leu Lys Ala Glu Ser 
                485                 490                 495     


Ser Asp Ala Gly Asn Ile Thr Thr Val Lys Leu Leu Met Pro Ala Ser 
            500                 505                 510         


Phe Asn Asn Thr Val Thr His Asp Leu Leu Ser Asp Ala Asn Leu Thr 
        515                 520                 525             


Glu Thr Ala His Ser Phe Ile Lys Tyr Leu Arg Ser Ser Asp Thr His 
    530                 535                 540                 


Val Asp Val Thr Phe Ser Asn Pro Pro Phe Asn Phe Ser Ser Leu Thr 
545                 550                 555                 560 


Pro Asp Glu Glu Gln Glu Val Arg Trp Tyr Ile His Asp Glu Val Met 
                565                 570                 575     


Asn Gln Ile Lys Lys Cys Glu Glu Arg Ser Thr Gly Arg Ser Met Ala 
            580                 585                 590         


Arg Arg Glu Glu Val Gly Asp Tyr Ser Arg Thr Thr Ile Ala Thr Ala 
        595                 600                 605             


Leu Asp Ser Asn Val Thr Gly Val Cys Gln Ser Thr Ile Thr Asn Arg 
    610                 615                 620                 


Thr Val Ser Leu Phe Tyr Gln Pro Pro Tyr Val Glu Met Ser Leu Tyr 
625                 630                 635                 640 


Glu Val Phe Ile Pro Gly Asn Tyr Thr Phe Asp Val Ser Glu Cys Val 
                645                 650                 655     


Gly Glu Ile Asp Trp Gln Asp Leu Asn Asp His Leu Asn Asn Asp Thr 
            660                 665                 670         


Val Arg Pro Thr Thr Glu Lys Ala Pro Lys Cys Gly Arg Val Cys Leu 
        675                 680                 685             


Ile Ile Ile Ala Val Val Cys Ala Leu Ile Val Ala Val Leu Ile Val 
    690                 695                 700                 


Leu Ala Val Val Phe Thr Ser Lys Arg Arg Arg Leu Ala Ala Val Val 
705                 710                 715                 720 


Ala Pro Ala Arg Pro Lys Phe Val Ser Thr Leu Asp Glu Asp Glu Gln 
                725                 730                 735     


Asp Tyr Ala Ser Ala Tyr Gly Asn Lys Glu Arg Val Glu Gln 
            740                 745                 750 


<210>  24
<211>  600
<212>  PRT
<213>  Trypanosoma brucei gambiense

<400>  24

Phe Val Glu Ser Ile Gly Glu Val Lys Tyr Phe Arg Asp Ser Gly Val 
1               5                   10                  15      


Phe Ser His Asp Val Val Arg Asn Gly Ser Leu Thr Gly Val Ala Leu 
            20                  25                  30          


Tyr Gly Asn His Leu Tyr Leu Thr Glu Gln Asn Thr Asn Thr Val Trp 
        35                  40                  45              


Thr Cys Glu Val Gly Ser Asp Gly Asp Pro Ile Ala Cys His Ser His 
    50                  55                  60                  


Val Ala Leu Ser Ala Lys Cys Ser Ile Tyr Gly Pro Ile Gly Ile Ala 
65                  70                  75                  80  


Ala Thr Gln Gln Gly Ile Phe Val Val Ala Arg Gly Pro Ala Lys Gln 
                85                  90                  95      


Gly Thr Ile Cys Trp Phe Asp Leu Gln Gly His Lys Ile Ala Glu Val 
            100                 105                 110         


Asp Gly Glu Tyr Val Asp Ile Thr Ser Thr Arg Ser Gly Asp Leu Leu 
        115                 120                 125             


Ala Ala Thr Gln Asn Glu Leu His Arg Val Ser Thr Asp Gly Asn Lys 
    130                 135                 140                 


Leu Thr Thr Lys Arg Phe Ala Gly Gly Ser Thr Asn Ser Cys Leu Pro 
145                 150                 155                 160 


Asn Thr Glu Gly Asp Asp Thr Leu Leu Cys Glu Ile Thr Arg Leu Leu 
                165                 170                 175     


Val Val Thr Glu Tyr Glu Met Tyr Val Thr Ser Glu Lys Lys Ser Val 
            180                 185                 190         


Leu Arg Ser Val Thr Leu Pro Pro Val Tyr Val Gln Gly Val Phe Pro 
        195                 200                 205             


Gly Arg Pro Leu Pro Val Gly Tyr Pro Asp Lys Asp Ile Met Glu Trp 
    210                 215                 220                 


Ile Val Gly Asn Leu Thr Glu Asp Ile Asn Thr Ala Leu Gly Thr Thr 
225                 230                 235                 240 


Glu Ser Ile Val Ala Ser Ser Ser Val His Val Asp Ser Thr Thr Trp 
                245                 250                 255     


Leu Thr Asn Phe Thr Ala Gly Val Gln Gln Pro Asp Phe Asp Asp Glu 
            260                 265                 270         


Lys Thr Glu Gln Ala Leu His Lys Ser Asn Tyr Glu His Thr Lys Glu 
        275                 280                 285             


Ala Ala Asp Glu Tyr Tyr Asn Leu Thr Asp Glu Gln Val Tyr Met Asp 
    290                 295                 300                 


Ser Thr Met Val Pro Tyr Cys Asn Arg Leu Ser Leu Asp Ala Leu Arg 
305                 310                 315                 320 


Arg Lys Leu Ala Lys Glu Ala Gly Glu Val Leu Asn Phe Thr Leu Ile 
                325                 330                 335     


Tyr Ala Asp Met Pro Leu Lys Ala Glu Ser Ser Asp Ala Gly Asn Ile 
            340                 345                 350         


Thr Thr Val Lys Leu Leu Met Pro Ala Ser Phe Asn Asn Thr Val Thr 
        355                 360                 365             


His Asp Leu Leu Ser Asp Ala Asn Leu Thr Glu Thr Ala His Ser Phe 
    370                 375                 380                 


Ile Lys Tyr Leu Arg Ser Ser Asp Thr His Val Asp Val Thr Phe Ser 
385                 390                 395                 400 


Asn Pro Pro Phe Asn Phe Ser Ser Leu Thr Pro Asp Glu Glu Gln Glu 
                405                 410                 415     


Val Arg Trp Tyr Ile His Asp Glu Val Met Asn Gln Ile Lys Lys Cys 
            420                 425                 430         


Glu Glu Arg Ser Thr Gly Arg Ser Met Ala Arg Arg Glu Glu Val Gly 
        435                 440                 445             


Asp Tyr Ser Arg Thr Thr Ile Ala Thr Ala Leu Asp Ser Asn Val Thr 
    450                 455                 460                 


Gly Val Cys Gln Ser Thr Ile Thr Asn Arg Thr Val Ser Leu Phe Tyr 
465                 470                 475                 480 


Gln Pro Pro Tyr Val Glu Met Ser Leu Tyr Glu Val Phe Ile Pro Gly 
                485                 490                 495     


Asn Tyr Thr Phe Asp Val Ser Glu Cys Val Gly Glu Ile Asp Trp Gln 
            500                 505                 510         


Asp Leu Asn Asp His Leu Asn Asn Asp Thr Val Arg Pro Thr Thr Glu 
        515                 520                 525             


Lys Ala Pro Lys Cys Gly Arg Val Cys Leu Ile Ile Ile Ala Val Val 
    530                 535                 540                 


Cys Ala Leu Ile Val Ala Val Leu Ile Val Leu Ala Val Val Phe Thr 
545                 550                 555                 560 


Ser Lys Arg Arg Arg Leu Ala Ala Val Val Ala Pro Ala Arg Pro Lys 
                565                 570                 575     


Phe Val Ser Thr Leu Asp Glu Asp Glu Gln Asp Tyr Ala Ser Ala Tyr 
            580                 585                 590         


Gly Asn Lys Glu Arg Val Glu Gln 
        595                 600 


<210>  25
<211>  151
<212>  PRT
<213>  Trypanosoma cruzi

<400>  25

Met Glu Leu Pro Pro Pro Pro Leu Pro Ile Gly Tyr Pro Asp Asp Asn 
1               5                   10                  15      


Glu Val Met Lys Lys Ile Ile Gln Leu Met Asn Glu Glu Leu Asn Glu 
            20                  25                  30          


His Leu Lys Thr Asn Gly Thr Tyr Val Ser Gln Glu Asn Met Tyr Val 
        35                  40                  45              


Asp Ala Asn Thr Trp Ala Thr Lys Phe Ala Val Met Val Gln Gln His 
    50                  55                  60                  


Asp Phe Glu Asn Ala Thr Thr Pro Gly Glu Val Leu Thr Thr His Phe 
65                  70                  75                  80  


Ala Gln Thr Lys Gln Phe Val Lys Asp Tyr Tyr Asp Arg Val Asp Glu 
                85                  90                  95      


Val Leu Tyr Met Asp Thr Ser Ile Met Pro Phe Cys Asn Asp Thr Met 
            100                 105                 110         


Leu Asn Ala Val Met His Arg Leu Val Ser Val Val Arg Glu Val Ser 
        115                 120                 125             


Val Phe Arg Leu Phe Thr Pro Thr Arg Gln Arg Leu Gly Arg Asn Leu 
    130                 135                 140                 


Ile Leu Lys Thr Ser Pro Gln 
145                 150     


<210>  26
<211>  218
<212>  PRT
<213>  Trypanosoma cruzi

<400>  26

Met Asp Ala Asp Met Asp Ala Ala Leu Leu Gln Ile Leu Arg Glu Leu 
1               5                   10                  15      


Tyr Gly Pro Glu Asn Val Val Thr Leu Val Phe Pro Met Pro Glu Tyr 
            20                  25                  30          


Asp Phe Ser Lys Leu Thr Asp Glu Gln Leu Val Glu Ile Arg Trp Phe 
        35                  40                  45              


Ile Leu Asp Met Val Arg Ala Arg Leu Glu Glu Cys Ala Val Leu Ser 
    50                  55                  60                  


Ala Gly Ser Val Asp Ala Ser Val Ser Arg His Ser Gly Val Cys Glu 
65                  70                  75                  80  


Ala Val Ile Thr Asn Arg Thr Glu Thr Val Ile Ser His Pro Pro Phe 
                85                  90                  95      


Asn Ile Gln Ser Glu Tyr Glu Val Phe Val Pro Ser Arg Tyr Asn Phe 
            100                 105                 110         


Asn Ala Ser Leu Cys Leu Asp Gly Ile Asp Trp Ala Val Leu Glu Glu 
        115                 120                 125             


Val Ile Lys Asn Tyr Thr Glu Glu Asn Lys Pro Arg His Lys Ser Ala 
    130                 135                 140                 


Cys Asp Arg Ser Cys Ile Ile Gly Leu Ala Val Leu Ala Ala Leu Val 
145                 150                 155                 160 


Leu Thr Ala Leu Ile Ala Val Val Val Val Leu Thr Ser Lys Arg Arg 
                165                 170                 175     


Arg Leu Ala Ala Val Val Ala Pro Val His Pro Lys Phe Lys Ser Thr 
            180                 185                 190         


Leu Asp Glu Asp Glu Glu Glu Ile Glu Thr Thr Asn Pro Leu Glu Leu 
        195                 200                 205             


Lys Glu Glu Gln Arg Ala Arg Asp Met Tyr 
    210                 215             


<210>  27
<211>  712
<212>  PRT
<213>  Trypanosoma cruzi

<400>  27

Met Phe Arg Phe Gln Ser Leu Leu Phe Ala Leu Phe Thr Gly Leu Leu 
1               5                   10                  15      


Phe Ser Phe Thr Ser Ser Val Val Val Ala Met Pro Leu Arg Tyr Met 
            20                  25                  30          


Val Glu Thr Val Ser Gly Ile Thr Gly Ser Ile Gly His Val Asn Gly 
        35                  40                  45              


Gly Pro Gly Ala Ser Leu Leu Thr Arg Pro Ser Ala Ile Cys Gln Gly 
    50                  55                  60                  


Arg Asn Glu Asp Glu Leu Leu Phe Gly Thr Gln Gly Tyr Phe Arg Asn 
65                  70                  75                  80  


Phe Ser Arg Ser Thr Lys Met Thr Gly Ile Leu Ile Gly Asp Gly Thr 
                85                  90                  95      


Ala Gln Ile Leu Asp Gly Thr Trp Ser Gln Ala Arg Ile Asp Gly Pro 
            100                 105                 110         


Arg Gly Cys Val Arg Gly Ile Phe Asn Gln Lys Met Ile Val Tyr Phe 
        115                 120                 125             


Val Glu Gly Gln Ser Ser Leu Arg Tyr Phe Thr Ser Asn Tyr Val His 
    130                 135                 140                 


Thr Val Ile Ile Ser Ile Asn Leu Ser Phe Thr Asp Val Lys Leu Tyr 
145                 150                 155                 160 


Glu Gly Lys Leu Tyr Ile Thr Glu Gln Thr Lys Asp Glu Val Trp Val 
                165                 170                 175     


Cys Asp Ile Asp Ala Asp Gly Ala Pro Val Ser Cys Ala Leu Lys Thr 
            180                 185                 190         


Gly Phe Lys Cys Asp Tyr Gly Lys Tyr His Gly Ile Thr Val Thr Lys 
        195                 200                 205             


Leu Gly Val Phe Val Val Gly Glu Ser Ala Ala Gly Ile Cys His Phe 
    210                 215                 220                 


Asp Met Asn Gly Asn Lys Ile Ser Val Leu Gly Gly Asn Tyr Ile Asp 
225                 230                 235                 240 


Val Phe Ser Leu Pro Ser Asp Glu Leu Tyr Ile Met Ser Tyr Thr Glu 
                245                 250                 255     


Leu Leu His Leu Arg Val Thr Gly Ser Ala Met Ala Val Glu Lys Phe 
            260                 265                 270         


Ala Gly Arg Ala Asp Ala Thr Cys Pro Pro Leu Ile Asp Gly Tyr Asp 
        275                 280                 285             


Phe Thr Leu Cys Lys Asn Leu Arg Leu Phe Val Ile Glu Gln Ser Glu 
    290                 295                 300                 


Met Tyr Leu Ala Thr Thr Leu Asn Thr Val Arg Ser Val Thr Leu Pro 
305                 310                 315                 320 


Pro Ala Ile Val Trp Met Glu Leu Pro Pro Pro Pro Leu Pro Ile Gly 
                325                 330                 335     


Tyr Pro Asp Asp Asn Glu Val Met Lys Lys Ile Ile Gln Leu Met Asn 
            340                 345                 350         


Glu Glu Leu Asn Glu His Leu Lys Thr Asn Gly Thr Tyr Val Ser Gln 
        355                 360                 365             


Glu Asn Met Tyr Val Asp Ala Asn Thr Trp Ala Thr Lys Phe Ala Val 
    370                 375                 380                 


Met Val Gln Gln His Asp Phe Glu Asn Ala Thr Thr Pro Gly Glu Val 
385                 390                 395                 400 


Leu Thr Thr His Phe Ala Gln Thr Lys Gln Phe Val Lys Asp Tyr Tyr 
                405                 410                 415     


Asp Arg Val Asp Glu Val Leu Tyr Met Asp Thr Ser Ile Met Pro Phe 
            420                 425                 430         


Cys Asn Asp Thr Met Leu Asn Ala Val Met His Arg Leu Val Ser Val 
        435                 440                 445             


Val Arg Glu Val Leu Gly Phe Pro Leu Ile Tyr Ala Asn Pro Pro Glu 
    450                 455                 460                 


Ala Arg Lys Glu Phe Asn Phe Glu Asn Ile Thr Thr Met Lys Leu Leu 
465                 470                 475                 480 


Met Pro Ala Ser Phe Asn Asn Asp Thr Thr Arg Asp Ala Leu Met Asp 
                485                 490                 495     


Ala Asp Met Asp Ala Ala Leu Leu Gln Ile Leu Arg Glu Leu Tyr Gly 
            500                 505                 510         


Pro Glu Asn Val Val Thr Leu Val Phe Pro Met Pro Glu Tyr Asp Phe 
        515                 520                 525             


Ser Lys Leu Thr Asp Glu Gln Leu Val Glu Ile Arg Trp Phe Ile Leu 
    530                 535                 540                 


Asp Met Val Arg Ala Arg Leu Glu Glu Cys Ala Val Leu Ser Ala Gly 
545                 550                 555                 560 


Ser Val Asp Ala Ser Val Ser Arg His Ser Gly Val Cys Glu Ala Val 
                565                 570                 575     


Ile Thr Asn Arg Thr Glu Thr Val Ile Ser His Pro Pro Phe Asn Ile 
            580                 585                 590         


Gln Ser Glu Tyr Glu Val Phe Val Pro Ser Arg Tyr Asn Phe Asn Ala 
        595                 600                 605             


Ser Leu Cys Leu Asp Gly Ile Asp Trp Ala Val Leu Glu Glu Val Ile 
    610                 615                 620                 


Lys Asn Tyr Thr Glu Glu Asn Lys Pro Arg His Lys Ser Ala Cys Asp 
625                 630                 635                 640 


Arg Ser Cys Ile Ile Gly Leu Ala Val Leu Ala Ala Leu Val Leu Thr 
                645                 650                 655     


Ala Leu Ile Ala Val Val Val Val Leu Thr Ser Lys Arg Arg Arg Leu 
            660                 665                 670         


Ala Ala Val Val Ala Pro Val His Pro Lys Phe Lys Ser Thr Leu Asp 
        675                 680                 685             


Glu Asp Glu Glu Glu Ile Glu Thr Thr Asn Pro Leu Glu Leu Lys Glu 
    690                 695                 700                 


Glu Gln Arg Ala Arg Asp Met Tyr 
705                 710         


<210>  28
<211>  708
<212>  PRT
<213>  Trypanosoma cruzi

<400>  28

Met Ser Arg Phe Gln Arg Leu Leu Phe Ala Leu Phe Ala Gly Phe Leu 
1               5                   10                  15      


Phe Ser Phe Thr Ala Ser Val Val Val Ala Met Pro Leu Arg Tyr Met 
            20                  25                  30          


Val Glu Thr Val Ser Gly Ile Thr Gly Ser Ile Gly His Val Asn Gly 
        35                  40                  45              


Gly Pro Gly Thr Ser Leu Leu Thr Arg Pro Ser Ala Ile Cys Gln Gly 
    50                  55                  60                  


Arg Asn Glu Asp Glu Leu Leu Phe Gly Thr Gln Gly Tyr Phe Arg Asn 
65                  70                  75                  80  


Phe Ser Arg Ser Thr Lys Met Thr Gly Ile Leu Leu Gly Asp Gly Thr 
                85                  90                  95      


Val Gln Ile Leu Asp Gly Thr Trp Ser Gln Ala Arg Ile Asp Gly Pro 
            100                 105                 110         


Arg Gly Cys Val Arg Gly Ile Phe Asn Gln Lys Met Ile Val Tyr Phe 
        115                 120                 125             


Val Glu Gly Gln Ser Ser Leu Arg Tyr Phe Thr Ser Asn Tyr Val His 
    130                 135                 140                 


Thr Val Thr Ile Ser Ile Asn Leu Ser Phe Thr Asp Val Lys Leu Tyr 
145                 150                 155                 160 


Glu Gly Lys Leu Tyr Ile Thr Glu Gln Thr Lys Asp Glu Val Trp Gly 
                165                 170                 175     


Cys Asp Ile Asp Ala Asp Gly Ala Pro Val Ser Cys Ala Leu Lys Thr 
            180                 185                 190         


Gly Phe Lys Cys Asp Tyr Gly Lys Tyr His Gly Ile Thr Val Thr Lys 
        195                 200                 205             


Leu Gly Val Phe Val Val Gly Glu Ser Ala Ala Gly Ile Cys His Phe 
    210                 215                 220                 


Asp Met His Gly Asn Lys Ile Ser Val Leu Gly Gly Asn Tyr Ile Asp 
225                 230                 235                 240 


Val Phe Ser Leu Pro Ser Asp Glu Leu Tyr Ile Met Ser Tyr Thr Glu 
                245                 250                 255     


Leu Leu His Leu Arg Val Ile Gly Ser Ala Met Val Val Glu Lys Phe 
            260                 265                 270         


Ala Gly Arg Ser Asp Ala Thr Cys Pro Pro Leu Ile Asp Gly Tyr Asp 
        275                 280                 285             


Phe Thr Leu Cys Lys Asn Leu Arg Leu Phe Val Ile Glu Gln Ser Glu 
    290                 295                 300                 


Met Tyr Leu Ala Thr Thr Leu Asn Thr Val Arg Ser Val Thr Leu Pro 
305                 310                 315                 320 


Pro Ala Ile Val Trp Ile Glu Leu Pro Pro Pro Pro Leu Pro Ile Gly 
                325                 330                 335     


Tyr Pro Asn Asp Asn Glu Val Met Lys Lys Ile Ile Gln Leu Met Asn 
            340                 345                 350         


Glu Glu Leu Asn Lys His Leu Gly Thr Asn Gly Thr Tyr Val Ser Gln 
        355                 360                 365             


Glu Thr Met His Val Asp Ala Asn Thr Trp Ala Thr Lys Phe Ala Val 
    370                 375                 380                 


Met Val Gln Gln Gln Asp Phe Glu Asn Ala Thr Thr Pro Gly Glu Val 
385                 390                 395                 400 


Leu Thr Thr His Phe Ala Arg Thr Lys Gln Phe Val Lys Asp Tyr Tyr 
                405                 410                 415     


Asp Arg Val Asn Glu Val Leu Tyr Met Asp Thr Ser Ile Met Pro Phe 
            420                 425                 430         


Cys Asn Asp Thr Met Leu Asn Ala Val Met His Arg Leu Val Thr Val 
        435                 440                 445             


Val Arg Glu Val Leu Ser Phe Pro Leu Ile Tyr Ala Asn Pro Pro Glu 
    450                 455                 460                 


Val Arg Lys Glu Phe Asp Phe Glu Asn Ile Thr Thr Met Lys Leu Leu 
465                 470                 475                 480 


Met Pro Ala Ser Phe Asn Asn Asp Thr Thr Arg Glu Ala Leu Met Asp 
                485                 490                 495     


Ala Asp Met Asp Ala Ala Leu Leu Gln Ile Leu Arg Glu Leu Tyr Gly 
            500                 505                 510         


Pro Glu His Val Val Thr Leu Val Phe Pro Met Pro Gln Tyr Asp Phe 
        515                 520                 525             


Ser Lys Leu Thr Asp Glu Gln Leu Val Glu Val Arg Trp Phe Ile Leu 
    530                 535                 540                 


Asp Leu Val Arg Ala Arg Leu Glu Glu Cys Ala Val Leu Ser Val Asp 
545                 550                 555                 560 


Gly Val Gly Ala Ser Val Ser Ser His Ser Ser Val Cys Glu Ala Val 
                565                 570                 575     


Ile Thr Asn Arg Thr Glu Thr Val Val Ser His Pro Pro Phe Asn Ile 
            580                 585                 590         


Gln Ser Glu Tyr Glu Val Phe Val Pro Ser Arg Tyr Lys Phe Asn Ala 
        595                 600                 605             


Ser Leu Cys Leu Asp Gly Ile Asp Trp Thr Val Leu Glu Glu Leu Ile 
    610                 615                 620                 


Lys Asn Tyr Thr Glu Glu Asn Lys Pro Arg His Lys Ser Ala Cys Asp 
625                 630                 635                 640 


Arg Ser Cys Ile Ile Gly Leu Ala Val Leu Ala Ala Leu Val Leu Thr 
                645                 650                 655     


Ala Leu Ile Ala Val Met Val Val Leu Thr Ser Lys Arg Arg Arg Leu 
            660                 665                 670         


Ala Ala Val Val Ala Pro Val His Pro Lys Phe Lys Ser Thr Leu Asp 
        675                 680                 685             


Glu Asp Glu Glu Glu Met Glu Thr Thr Asn Pro Leu Glu Val Lys Asp 
    690                 695                 700                 


Glu Gln Arg Ala 
705             


<210>  29
<211>  366
<212>  PRT
<213>  Trypanosoma cruzi

<400>  29

Met Phe Trp Phe Gln Ser Leu Leu Phe Ala Leu Phe Ala Gly Leu Leu 
1               5                   10                  15      


Phe Ser Phe Thr Ser Ser Val Val Val Ala Met Pro Leu Arg Tyr Met 
            20                  25                  30          


Val Glu Thr Val Ser Gly Ile Thr Gly Ser Ile Gly His Ala Asn Gly 
        35                  40                  45              


Gly Pro Gly Thr Ser Leu Leu Thr Arg Pro Ser Ala Ile Cys Gln Gly 
    50                  55                  60                  


Arg Asn Glu Asp Glu Leu Leu Phe Gly Thr Gln Gly Tyr Phe Arg Asn 
65                  70                  75                  80  


Phe Ser Arg Ser Thr Lys Met Thr Gly Ile Leu Ile Gly Asp Gly Thr 
                85                  90                  95      


Ala Gln Ile Leu Asp Gly Thr Trp Ser Gln Ala Arg Ile Asp Gly Pro 
            100                 105                 110         


Arg Gly Cys Val Arg Gly Ile Phe Ser Gln Lys Met Ile Val Tyr Phe 
        115                 120                 125             


Val Glu Gly Gln Ser Ser Leu Arg Tyr Phe Thr Ser Asp Tyr Val His 
    130                 135                 140                 


Thr Val Met Ile Ser Ile Asn Leu Phe Phe Thr Asp Val Lys Leu Tyr 
145                 150                 155                 160 


Glu Gly Lys Leu Tyr Met Thr Glu Gln Thr Lys Asp Glu Val Trp Gly 
                165                 170                 175     


Cys Asp Ile Asp Ala Asp Gly Ala Pro Val Ser Cys Ala Leu Lys Thr 
            180                 185                 190         


Gly Phe Lys Cys Asp Tyr Gly Lys Tyr His Gly Ile Thr Val Thr Lys 
        195                 200                 205             


Gln Gly Val Phe Val Val Gly Glu Ser Ala Ala Gly Ile Cys His Phe 
    210                 215                 220                 


Asp Met His Gly Asn Lys Leu Ser Val Leu Gly Gly Asn Tyr Ile Asp 
225                 230                 235                 240 


Val Phe Ser Leu Pro Ser Asp Glu Leu Tyr Ile Met Ser Tyr Thr Glu 
                245                 250                 255     


Leu Phe His Leu Arg Val Ile Gly Ser Ala Met Val Val Glu Lys Phe 
            260                 265                 270         


Ala Gly Arg Ala Asp Ala Thr Cys Pro Pro Leu Ile Asp Gly Tyr Asp 
        275                 280                 285             


Phe Thr Leu Cys Lys Asn Leu Arg Leu Phe Val Ile Asp Gln Ser Glu 
    290                 295                 300                 


Met Tyr Leu Ala Thr Thr Leu Asn Thr Val Arg Ser Val Thr Leu Pro 
305                 310                 315                 320 


Pro Ala Ile Val Trp Met Glu Leu Pro Pro Pro Pro Leu Pro Ile Gly 
                325                 330                 335     


Tyr Pro Asp Glu Tyr Glu Val Met Lys Arg Ile Ile Gln Leu Met Asn 
            340                 345                 350         


Glu Glu Leu Asn Glu His Leu Arg Thr Asn Gly Thr Tyr Val 
        355                 360                 365     


<210>  30
<211>  712
<212>  PRT
<213>  Trypanosoma cruzi

<400>  30

Met Phe Arg Phe Gln Ser Leu Leu Phe Ala Leu Phe Thr Gly Leu Leu 
1               5                   10                  15      


Phe Ser Phe Thr Ser Ser Val Val Val Ala Met Pro Leu Arg Tyr Met 
            20                  25                  30          


Val Glu Thr Val Ser Gly Ile Thr Gly Ser Ile Gly His Val Asn Gly 
        35                  40                  45              


Gly Pro Gly Ala Ser Leu Leu Thr Arg Pro Ser Ala Ile Cys Lys Gly 
    50                  55                  60                  


Arg Asn Glu Asp Glu Leu Leu Phe Gly Thr Gln Gly Tyr Phe Arg Asn 
65                  70                  75                  80  


Phe Ser Arg Ser Thr Lys Met Thr Gly Ile Leu Ile Gly Asp Gly Thr 
                85                  90                  95      


Ala Gln Ile Leu Asp Gly Thr Trp Ser Gln Ala Arg Ile Asp Gly Pro 
            100                 105                 110         


Arg Gly Cys Val Arg Gly Ile Phe Asn Gln Lys Met Ile Val Tyr Phe 
        115                 120                 125             


Val Glu Gly Gln Ser Ser Leu Arg Tyr Phe Thr Ser Asn Tyr Val His 
    130                 135                 140                 


Thr Val Ile Ile Ser Ile Asn Leu Ser Phe Thr Asp Val Lys Leu Tyr 
145                 150                 155                 160 


Glu Gly Lys Leu Tyr Ile Thr Glu Gln Thr Lys Asp Glu Val Trp Val 
                165                 170                 175     


Cys Asp Ile Asp Ala Asp Gly Ala Pro Val Ser Cys Ala Leu Lys Thr 
            180                 185                 190         


Gly Phe Lys Cys Asp Tyr Gly Lys Tyr His Gly Ile Thr Val Thr Lys 
        195                 200                 205             


Leu Gly Val Phe Val Val Gly Glu Ser Ala Ala Gly Ile Cys His Phe 
    210                 215                 220                 


Asp Met Asn Gly Asn Lys Ile Ser Val Leu Gly Gly Asn Tyr Ile Asp 
225                 230                 235                 240 


Val Phe Ser Leu Pro Ser Asp Glu Leu Tyr Ile Met Ser Tyr Thr Glu 
                245                 250                 255     


Leu Leu His Leu Arg Val Thr Gly Ser Ala Met Ala Val Glu Lys Phe 
            260                 265                 270         


Ala Gly Arg Ala Asp Ala Thr Cys Pro Pro Leu Ile Asp Gly Tyr Asp 
        275                 280                 285             


Phe Thr Leu Cys Lys Asn Leu Arg Leu Phe Val Ile Glu Gln Ser Glu 
    290                 295                 300                 


Met Tyr Leu Ala Thr Thr Leu Asn Thr Val Arg Ser Val Thr Leu Pro 
305                 310                 315                 320 


Pro Ala Ile Val Trp Met Glu Leu Pro Pro Pro Pro Leu Pro Ile Gly 
                325                 330                 335     


Tyr Pro Asp Asp Asn Glu Val Met Lys Lys Ile Ile Gln Leu Met Asn 
            340                 345                 350         


Glu Glu Leu Asn Glu His Leu Lys Thr Asn Gly Thr Tyr Val Ser Gln 
        355                 360                 365             


Glu Asn Met Tyr Val Asp Ala Asn Thr Trp Ala Thr Lys Phe Ala Val 
    370                 375                 380                 


Met Val Gln Gln His Asp Phe Glu Asn Ala Thr Thr Pro Gly Glu Val 
385                 390                 395                 400 


Leu Thr Thr His Phe Ala Gln Thr Lys Gln Phe Val Lys Asp Tyr Tyr 
                405                 410                 415     


Asp Arg Val Asp Glu Val Leu Tyr Met Asp Thr Ser Ile Met Pro Phe 
            420                 425                 430         


Cys Asn Asp Thr Met Leu Asn Ala Val Met His Arg Leu Val Ser Val 
        435                 440                 445             


Val Arg Glu Val Leu Gly Phe Pro Leu Ile Tyr Ala Asn Pro Pro Glu 
    450                 455                 460                 


Ala Arg Lys Glu Phe Asn Phe Glu Asn Ile Thr Thr Met Lys Leu Leu 
465                 470                 475                 480 


Met Pro Ala Ser Phe Asn Asn Asp Thr Thr Arg Asp Ala Leu Met Asp 
                485                 490                 495     


Ala Asp Met Asp Ala Ala Leu Leu Gln Ile Leu Trp Glu Leu Tyr Gly 
            500                 505                 510         


Pro Glu Asn Val Val Thr Leu Val Phe Pro Met Pro Glu Tyr Asp Phe 
        515                 520                 525             


Ser Lys Leu Thr Asp Glu Gln Leu Val Glu Ile Arg Trp Phe Ile Leu 
    530                 535                 540                 


Asp Met Val Arg Ala Arg Leu Glu Glu Cys Ala Val Leu Ser Ala Gly 
545                 550                 555                 560 


Ser Val Asp Ala Ser Val Ser Arg His Ser Gly Val Cys Glu Ala Val 
                565                 570                 575     


Ile Thr Asn Arg Thr Glu Thr Val Ile Ser His Pro Pro Phe Asn Ile 
            580                 585                 590         


Gln Ser Glu Tyr Glu Val Phe Val Pro Ser Arg Tyr Asn Phe Asn Ala 
        595                 600                 605             


Ser Leu Cys Leu Asp Gly Ile Asp Trp Ala Val Leu Glu Glu Val Ile 
    610                 615                 620                 


Lys Asn Tyr Thr Glu Glu Asn Lys Pro Arg His Lys Ser Ala Cys Asp 
625                 630                 635                 640 


Arg Ser Cys Ile Ile Gly Leu Ala Val Leu Ala Ala Leu Val Leu Thr 
                645                 650                 655     


Ala Leu Ile Ala Val Val Val Val Leu Thr Ser Lys Arg Arg Arg Leu 
            660                 665                 670         


Ala Ala Val Val Ala Pro Val His Pro Lys Phe Lys Ser Thr Leu Asp 
        675                 680                 685             


Glu Asp Glu Glu Glu Ile Glu Thr Thr Asn Pro Leu Glu Leu Lys Glu 
    690                 695                 700                 


Glu Gln Arg Ala Arg Asp Met Tyr 
705                 710         


<210>  31
<211>  712
<212>  PRT
<213>  Trypanosoma cruzi

<400>  31

Met Phe Arg Phe Gln Ser Leu Leu Phe Ala Leu Phe Thr Gly Leu Leu 
1               5                   10                  15      


Phe Ser Phe Thr Ser Ser Val Val Val Ala Met Pro Leu Arg Tyr Met 
            20                  25                  30          


Val Glu Thr Val Ser Gly Ile Thr Gly Ser Ile Gly His Val Asn Gly 
        35                  40                  45              


Gly Pro Gly Ala Ser Leu Leu Thr Arg Pro Ser Ala Ile Cys Lys Gly 
    50                  55                  60                  


Arg Asn Glu Asp Glu Leu Leu Phe Gly Thr Gln Gly Tyr Phe Arg Asn 
65                  70                  75                  80  


Phe Ser Arg Ser Thr Lys Met Thr Gly Ile Leu Ile Gly Asp Gly Thr 
                85                  90                  95      


Ala Gln Ile Leu Asp Gly Thr Trp Ser Gln Ala Arg Ile Asp Gly Pro 
            100                 105                 110         


Arg Gly Cys Val Arg Gly Ile Phe Asn Gln Lys Met Ile Val Tyr Phe 
        115                 120                 125             


Val Glu Gly Gln Ser Ser Leu Arg Tyr Phe Thr Ser Asn Tyr Val His 
    130                 135                 140                 


Thr Val Ile Ile Ser Ile Asn Leu Ser Phe Thr Asp Val Lys Leu Tyr 
145                 150                 155                 160 


Glu Gly Lys Leu Tyr Ile Thr Glu Gln Thr Lys Asp Glu Val Trp Val 
                165                 170                 175     


Cys Asp Ile Asp Ala Asp Gly Ala Pro Val Ser Cys Ala Leu Lys Thr 
            180                 185                 190         


Gly Phe Lys Cys Asp Tyr Gly Lys Tyr His Gly Ile Thr Val Thr Lys 
        195                 200                 205             


Leu Gly Val Phe Val Val Gly Glu Ser Ala Ala Gly Ile Cys His Phe 
    210                 215                 220                 


Asp Met Asn Gly Asn Lys Ile Ser Val Leu Gly Gly Asn Tyr Ile Asp 
225                 230                 235                 240 


Val Phe Ser Leu Pro Ser Asp Glu Leu Tyr Ile Met Ser Tyr Thr Glu 
                245                 250                 255     


Leu Leu His Leu Arg Val Thr Gly Ser Ala Met Ala Val Glu Lys Phe 
            260                 265                 270         


Ala Gly Arg Ala Asp Ala Thr Cys Pro Pro Leu Ile Asp Gly Tyr Asp 
        275                 280                 285             


Phe Thr Leu Cys Lys Asn Leu Arg Leu Phe Val Ile Glu Gln Ser Glu 
    290                 295                 300                 


Met Tyr Leu Ala Thr Thr Leu Asn Thr Val Arg Ser Val Thr Leu Pro 
305                 310                 315                 320 


Pro Ala Ile Val Trp Met Glu Leu Pro Pro Pro Pro Leu Pro Ile Gly 
                325                 330                 335     


Tyr Pro Asp Asp Asn Glu Val Met Lys Lys Ile Ile Gln Leu Met Asn 
            340                 345                 350         


Glu Glu Leu Asn Glu His Leu Lys Thr Asn Gly Thr Tyr Val Ser Gln 
        355                 360                 365             


Glu Asn Met Tyr Val Asp Ala Asn Thr Trp Ala Thr Lys Phe Ala Val 
    370                 375                 380                 


Met Val Gln Gln His Asp Phe Glu Asn Ala Thr Thr Pro Gly Glu Val 
385                 390                 395                 400 


Leu Thr Thr His Phe Ala Gln Thr Lys Gln Phe Val Lys Asp Tyr Tyr 
                405                 410                 415     


Asp Arg Val Asp Glu Val Leu Tyr Met Asp Thr Ser Ile Met Pro Phe 
            420                 425                 430         


Cys Asn Asp Thr Met Leu Asn Ala Val Met His Arg Leu Val Ser Val 
        435                 440                 445             


Val Arg Glu Val Leu Gly Phe Pro Leu Ile Tyr Ala Asn Pro Pro Glu 
    450                 455                 460                 


Ala Arg Lys Glu Phe Asn Phe Glu Asn Ile Thr Thr Met Lys Leu Leu 
465                 470                 475                 480 


Met Pro Ala Ser Phe Asn Asn Asp Thr Thr Arg Asp Ala Leu Met Asp 
                485                 490                 495     


Ala Asp Met Asp Ala Ala Leu Leu Gln Ile Leu Trp Glu Leu Tyr Gly 
            500                 505                 510         


Pro Glu Asn Val Val Thr Leu Val Phe Pro Met Pro Glu Tyr Asp Phe 
        515                 520                 525             


Ser Lys Leu Thr Asp Glu Gln Leu Val Glu Ile Arg Trp Phe Ile Leu 
    530                 535                 540                 


Asp Met Val Arg Ala Arg Leu Glu Glu Cys Ala Val Leu Ser Ala Gly 
545                 550                 555                 560 


Ser Val Asp Ala Ser Val Ser Arg His Ser Gly Val Cys Glu Ala Val 
                565                 570                 575     


Ile Thr Asn Arg Thr Glu Thr Val Ile Ser His Pro Pro Phe Asn Ile 
            580                 585                 590         


Gln Ser Glu Tyr Glu Val Phe Val Pro Ser Arg Tyr Asn Phe Asn Ala 
        595                 600                 605             


Ser Leu Cys Leu Asp Gly Ile Asp Trp Ala Val Leu Glu Glu Val Ile 
    610                 615                 620                 


Lys Asn Tyr Thr Glu Glu Asn Lys Pro Arg His Lys Ser Ala Cys Asp 
625                 630                 635                 640 


Arg Ser Cys Ile Ile Gly Leu Ala Val Leu Ala Ala Leu Val Leu Thr 
                645                 650                 655     


Ala Leu Ile Ala Val Val Val Val Leu Thr Ser Lys Arg Arg Arg Leu 
            660                 665                 670         


Ala Ala Val Val Ala Pro Val His Pro Lys Phe Lys Ser Thr Leu Asp 
        675                 680                 685             


Glu Asp Glu Glu Glu Ile Glu Thr Thr Asn Pro Leu Glu Leu Lys Glu 
    690                 695                 700                 


Glu Gln Arg Ala Arg Asp Met Tyr 
705                 710         


<210>  32
<211>  712
<212>  PRT
<213>  Trypanosoma cruzi

<400>  32

Met Phe Arg Phe Gln Ser Leu Leu Phe Ala Leu Phe Thr Gly Leu Leu 
1               5                   10                  15      


Phe Ser Phe Thr Ser Ser Val Val Val Ala Met Pro Leu Arg Tyr Met 
            20                  25                  30          


Val Glu Thr Val Ser Gly Ile Thr Gly Ser Ile Gly His Val Asn Gly 
        35                  40                  45              


Gly Pro Gly Ala Ser Leu Leu Thr Arg Pro Ser Ala Ile Cys Lys Gly 
    50                  55                  60                  


Arg Asn Glu Asp Glu Leu Leu Phe Gly Thr Gln Gly Tyr Phe Arg Asn 
65                  70                  75                  80  


Phe Ser Arg Ser Thr Lys Met Thr Gly Ile Leu Ile Gly Asp Gly Thr 
                85                  90                  95      


Ala Gln Ile Leu Asp Gly Thr Trp Ser Gln Ala Arg Ile Asp Gly Pro 
            100                 105                 110         


Arg Gly Cys Val Arg Gly Ile Phe Asn Gln Lys Met Ile Val Tyr Phe 
        115                 120                 125             


Val Glu Gly Gln Ser Ser Leu Arg Tyr Phe Thr Ser Asn Tyr Val His 
    130                 135                 140                 


Thr Val Ile Ile Ser Ile Asn Leu Ser Phe Thr Asp Val Lys Leu Tyr 
145                 150                 155                 160 


Glu Gly Lys Leu Tyr Ile Thr Glu Gln Thr Lys Asp Glu Val Trp Val 
                165                 170                 175     


Cys Asp Ile Asp Ala Asp Gly Ala Pro Val Ser Cys Ala Leu Lys Thr 
            180                 185                 190         


Gly Phe Lys Cys Asp Tyr Gly Lys Tyr His Gly Ile Thr Val Thr Lys 
        195                 200                 205             


Leu Gly Val Phe Val Val Gly Glu Ser Ala Ala Gly Ile Cys His Phe 
    210                 215                 220                 


Asp Met Asn Gly Asn Lys Ile Ser Val Leu Gly Gly Asn Tyr Ile Asp 
225                 230                 235                 240 


Val Phe Ser Leu Pro Ser Asp Glu Leu Tyr Ile Met Ser Tyr Thr Glu 
                245                 250                 255     


Leu Leu His Leu Arg Val Thr Gly Ser Ala Met Ala Val Glu Lys Phe 
            260                 265                 270         


Ala Gly Arg Ala Asp Ala Thr Cys Pro Pro Leu Ile Asp Gly Tyr Asp 
        275                 280                 285             


Phe Thr Leu Cys Lys Asn Leu Arg Leu Phe Val Ile Glu Gln Ser Glu 
    290                 295                 300                 


Met Tyr Leu Ala Thr Thr Leu Asn Thr Val Arg Ser Val Thr Leu Pro 
305                 310                 315                 320 


Pro Ala Ile Val Trp Met Glu Leu Pro Pro Pro Pro Leu Pro Ile Gly 
                325                 330                 335     


Tyr Pro Asp Asp Asn Glu Val Met Lys Lys Ile Ile Gln Leu Met Asn 
            340                 345                 350         


Glu Glu Leu Asn Glu His Leu Lys Thr Asn Gly Thr Tyr Val Ser Gln 
        355                 360                 365             


Glu Asn Met Tyr Val Asp Ala Asn Thr Trp Ala Thr Lys Phe Ala Val 
    370                 375                 380                 


Met Val Gln Gln His Asp Phe Glu Asn Ala Thr Thr Pro Gly Glu Val 
385                 390                 395                 400 


Leu Thr Thr His Phe Ala Gln Thr Lys Gln Phe Val Lys Asp Tyr Tyr 
                405                 410                 415     


Asp Arg Val Asp Glu Val Leu Tyr Met Asp Thr Ser Ile Met Pro Phe 
            420                 425                 430         


Cys Asn Asp Thr Met Leu Asn Ala Val Met His Arg Leu Val Ser Val 
        435                 440                 445             


Val Arg Glu Val Leu Gly Phe Pro Leu Ile Tyr Ala Asn Pro Pro Glu 
    450                 455                 460                 


Ala Arg Lys Glu Phe Asn Phe Glu Asn Ile Thr Thr Met Lys Leu Leu 
465                 470                 475                 480 


Met Pro Ala Ser Phe Asn Asn Asp Thr Thr Arg Asp Ala Leu Met Asp 
                485                 490                 495     


Ala Asp Met Asp Ala Ala Leu Leu Gln Ile Leu Trp Glu Leu Tyr Gly 
            500                 505                 510         


Pro Glu Asn Val Val Thr Leu Val Phe Pro Met Pro Glu Tyr Asp Phe 
        515                 520                 525             


Ser Lys Leu Thr Asp Glu Gln Leu Val Glu Ile Arg Trp Phe Ile Leu 
    530                 535                 540                 


Asp Met Val Arg Ala Arg Leu Glu Glu Cys Ala Val Leu Ser Ala Gly 
545                 550                 555                 560 


Ser Val Asp Ala Ser Val Ser Arg His Ser Gly Val Cys Glu Ala Val 
                565                 570                 575     


Ile Thr Asn Arg Thr Glu Thr Val Ile Ser His Pro Pro Phe Asn Ile 
            580                 585                 590         


Gln Ser Glu Tyr Glu Val Phe Val Pro Ser Arg Tyr Asn Phe Asn Ala 
        595                 600                 605             


Ser Leu Cys Leu Asp Gly Ile Asp Trp Ala Val Leu Glu Glu Val Ile 
    610                 615                 620                 


Lys Asn Tyr Thr Glu Glu Asn Lys Pro Arg His Lys Ser Ala Cys Asp 
625                 630                 635                 640 


Arg Ser Cys Ile Ile Gly Leu Ala Val Leu Ala Ala Leu Val Leu Thr 
                645                 650                 655     


Ala Leu Ile Ala Val Val Val Val Leu Thr Ser Lys Arg Arg Arg Leu 
            660                 665                 670         


Ala Ala Val Val Ala Pro Val His Pro Lys Phe Lys Ser Thr Leu Asp 
        675                 680                 685             


Glu Asp Glu Glu Glu Ile Glu Thr Thr Asn Pro Leu Glu Leu Lys Glu 
    690                 695                 700                 


Glu Gln Arg Ala Arg Asp Met Tyr 
705                 710         


<210>  33
<211>  217
<212>  PRT
<213>  Trypanosoma cruzi

<400>  33

Met Asp Ala Asp Met Asp Ala Ala Leu Leu Gln Ile Leu Arg Glu Leu 
1               5                   10                  15      


Tyr Gly Pro Glu Asn Val Val Thr Leu Val Phe Pro Met Pro Glu Tyr 
            20                  25                  30          


Asp Phe Ser Lys Leu Thr Asp Glu Gln Leu Val Glu Ile Arg Trp Phe 
        35                  40                  45              


Ile Leu Asp Met Val Arg Ala Arg Leu Glu Glu Cys Ala Val Leu Ser 
    50                  55                  60                  


Ala Gly Ser Val Asp Ala Ser Val Ser Arg His Ser Gly Val Cys Glu 
65                  70                  75                  80  


Ala Val Ile Thr Asn Arg Thr Glu Thr Val Ile Pro His Pro Pro Phe 
                85                  90                  95      


Asn Ile Gln Ser Glu Tyr Glu Val Phe Val Pro Ser Arg Tyr Asn Phe 
            100                 105                 110         


Asn Ala Ser Leu Cys Leu Asp Gly Ile Asp Trp Ala Val Leu Glu Glu 
        115                 120                 125             


Val Ile Lys Asn Tyr Thr Glu Glu Asn Lys Pro Arg His Lys Ser Ala 
    130                 135                 140                 


Cys Asp Arg Ser Cys Ile Ile Gly Leu Ala Val Leu Ala Ala Leu Val 
145                 150                 155                 160 


Leu Thr Ala Leu Ile Ala Val Val Val Val Leu Thr Ser Lys Arg Arg 
                165                 170                 175     


Arg Leu Ala Ala Val Val Ala Pro Val His Pro Lys Phe Lys Ser Thr 
            180                 185                 190         


Leu Asp Glu Asp Glu Glu Glu Ile Glu Thr Thr Asn Pro Leu Glu Leu 
        195                 200                 205             


Lys Glu Glu Gln Arg Ala Arg Asp Met 
    210                 215         


<210>  34
<211>  353
<212>  PRT
<213>  Trypanosoma cruzi

<400>  34

Met Ile Val Tyr Phe Val Glu Gly Gln Ser Ser Leu Arg Tyr Phe Thr 
1               5                   10                  15      


Ser Asn Tyr Val His Thr Val Ile Ile Ser Ile Asn Leu Ser Phe Thr 
            20                  25                  30          


Asp Val Lys Leu Tyr Glu Gly Lys Leu Tyr Ile Thr Glu Gln Thr Lys 
        35                  40                  45              


Asp Glu Val Trp Val Cys Asp Ile Asp Ala Asp Gly Ala Pro Val Ser 
    50                  55                  60                  


Cys Ala Leu Lys Thr Gly Phe Lys Cys Asp Tyr Gly Lys Tyr His Gly 
65                  70                  75                  80  


Ile Thr Val Thr Lys Leu Gly Val Phe Val Val Gly Glu Ser Ala Ala 
                85                  90                  95      


Gly Ile Cys His Phe Asp Met Asn Gly Asn Lys Ile Ser Val Leu Gly 
            100                 105                 110         


Gly Asn Tyr Ile Asp Val Phe Ser Leu Pro Ser Asp Glu Leu Tyr Ile 
        115                 120                 125             


Met Ser Tyr Thr Glu Leu Leu His Leu Arg Val Thr Gly Ser Ala Met 
    130                 135                 140                 


Ala Val Glu Lys Phe Ala Gly Arg Ala Asp Ala Thr Cys Pro Pro Leu 
145                 150                 155                 160 


Ile Asp Gly Tyr Asp Phe Thr Leu Cys Lys Asn Leu Arg Leu Phe Val 
                165                 170                 175     


Ile Glu Gln Ser Glu Met Tyr Leu Ala Thr Thr Leu Asn Thr Val Arg 
            180                 185                 190         


Ser Val Thr Leu Pro Pro Ala Ile Val Trp Met Glu Leu Pro Pro Pro 
        195                 200                 205             


Pro Leu Pro Ile Gly Tyr Pro Asp Asp Asn Glu Val Met Lys Lys Ile 
    210                 215                 220                 


Ile Gln Leu Met Asn Glu Glu Leu Asn Glu His Leu Lys Thr Asn Gly 
225                 230                 235                 240 


Thr Tyr Val Ser Gln Glu Asn Met Tyr Val Asp Asp Asn Thr Trp Ala 
                245                 250                 255     


Thr Lys Phe Ala Val Met Val Gln Gln His Asp Phe Glu Asn Ala Thr 
            260                 265                 270         


Thr Pro Gly Glu Val Leu Thr Thr His Phe Ala Gln Thr Lys Gln Phe 
        275                 280                 285             


Val Lys Asp Tyr Tyr Asp Arg Val Asp Glu Val Leu Tyr Met Asp Thr 
    290                 295                 300                 


Ser Ile Met Pro Phe Cys Asn Asp Thr Met Leu Asn Ala Val Met His 
305                 310                 315                 320 


Arg Leu Val Ser Val Val Arg Glu Val Leu Val Phe Arg Leu Phe Thr 
                325                 330                 335     


Pro Thr Arg Gln Arg Leu Gly Arg Asn Leu Ile Leu Lys Thr Ser Pro 
            340                 345                 350         


Gln 
    


<210>  35
<211>  711
<212>  PRT
<213>  Trypanosoma cruzi

<400>  35

Met Phe Arg Phe Gln Ser Leu Leu Phe Ala Leu Phe Thr Gly Leu Leu 
1               5                   10                  15      


Phe Ser Phe Thr Ser Ser Val Val Val Ala Met Pro Leu Arg Tyr Met 
            20                  25                  30          


Val Glu Thr Val Ser Gly Ile Thr Gly Ser Ile Gly His Val Asn Gly 
        35                  40                  45              


Gly Pro Gly Ala Ser Leu Leu Thr Arg Pro Ser Ala Ile Cys Gln Gly 
    50                  55                  60                  


Arg Asn Glu Glu Glu Leu Leu Phe Gly Thr Gln Gly Tyr Phe Arg Asn 
65                  70                  75                  80  


Phe Ser Arg Ser Thr Lys Met Thr Gly Ile Leu Ile Gly Asp Gly Thr 
                85                  90                  95      


Ala Gln Ile Leu Asp Gly Thr Trp Ser Gln Ala Arg Ile Asp Gly Pro 
            100                 105                 110         


Arg Gly Cys Val Arg Gly Ile Phe Asn Gln Lys Met Ile Val Tyr Phe 
        115                 120                 125             


Val Glu Gly Gln Ser Ser Leu Arg Tyr Phe Thr Ser Asn Tyr Val His 
    130                 135                 140                 


Thr Val Ile Ile Ser Ile Asn Leu Ser Phe Thr Asp Val Lys Leu Tyr 
145                 150                 155                 160 


Glu Gly Lys Leu Tyr Ile Thr Glu Gln Thr Lys Asp Glu Val Trp Val 
                165                 170                 175     


Cys Asp Ile Asp Ala Asp Gly Ala Pro Val Ser Cys Ala Leu Lys Thr 
            180                 185                 190         


Gly Phe Lys Cys Asp Tyr Gly Lys Tyr His Gly Ile Thr Val Thr Lys 
        195                 200                 205             


Leu Gly Val Phe Val Val Gly Glu Ser Ala Ala Gly Ile Cys His Phe 
    210                 215                 220                 


Asp Met Asn Gly Asn Lys Ile Ser Val Leu Gly Gly Asn Tyr Ile Asp 
225                 230                 235                 240 


Val Phe Ser Leu Pro Ser Asp Glu Leu Tyr Ile Met Ser Tyr Thr Glu 
                245                 250                 255     


Leu Leu His Leu Arg Val Thr Gly Ser Ala Met Ala Val Glu Lys Phe 
            260                 265                 270         


Ala Gly Arg Ala Asp Ala Thr Cys Pro Pro Leu Ile Asp Gly Tyr Asp 
        275                 280                 285             


Phe Thr Leu Cys Lys Asn Leu Arg Leu Phe Val Ile Glu Gln Ser Glu 
    290                 295                 300                 


Met Tyr Leu Ala Thr Thr Leu Asn Thr Val Arg Ser Val Thr Leu Pro 
305                 310                 315                 320 


Pro Ala Ile Val Trp Met Glu Leu Pro Pro Pro Pro Leu Pro Ile Gly 
                325                 330                 335     


Tyr Pro Asp Asp Asn Glu Val Met Lys Lys Ile Ile Gln Leu Met Asn 
            340                 345                 350         


Glu Glu Leu Asn Glu His Leu Lys Thr Asn Gly Thr Tyr Val Ser Gln 
        355                 360                 365             


Glu Asn Met Tyr Val Asp Ala Asn Thr Trp Ala Thr Lys Phe Ala Val 
    370                 375                 380                 


Met Val Gln Gln His Asp Phe Glu Asn Ala Thr Thr Pro Gly Glu Val 
385                 390                 395                 400 


Leu Thr Thr His Phe Ala Gln Thr Lys Gln Phe Val Lys Asp Tyr Tyr 
                405                 410                 415     


Asp Arg Val Asp Glu Val Leu Tyr Met Asp Thr Ser Ile Met Pro Phe 
            420                 425                 430         


Cys Asn Asp Thr Met Leu Asn Ala Val Met His Arg Leu Val Ser Val 
        435                 440                 445             


Val Arg Glu Val Leu Gly Phe Pro Leu Ile Tyr Ala Asn Pro Pro Glu 
    450                 455                 460                 


Ala Arg Lys Glu Phe Asn Phe Glu Asn Ile Thr Thr Met Lys Leu Leu 
465                 470                 475                 480 


Met Pro Ala Ser Phe Asn Asn Asp Thr Thr Arg Asp Ala Leu Met Asp 
                485                 490                 495     


Ala Asp Met Asp Ala Ala Leu Leu Gln Ile Leu Arg Glu Leu Tyr Gly 
            500                 505                 510         


Pro Glu Asn Val Val Thr Leu Val Phe Pro Met Pro Glu Tyr Asp Phe 
        515                 520                 525             


Ser Lys Leu Thr Asp Glu Gln Leu Val Glu Ile Arg Trp Phe Ile Leu 
    530                 535                 540                 


Asp Met Val Arg Ala Arg Leu Glu Glu Cys Ala Val Leu Ser Ala Gly 
545                 550                 555                 560 


Ser Val Asp Ala Ser Val Ser Arg His Ser Gly Val Cys Glu Ala Val 
                565                 570                 575     


Ile Thr Asn Arg Thr Glu Thr Val Ile Pro His Pro Pro Phe Asn Ile 
            580                 585                 590         


Gln Ser Glu Tyr Glu Val Phe Val Pro Ser Arg Tyr Asn Phe Asn Ala 
        595                 600                 605             


Ser Leu Cys Leu Asp Gly Ile Asp Trp Ala Val Leu Glu Glu Val Ile 
    610                 615                 620                 


Lys Asn Tyr Thr Glu Glu Asn Lys Pro Arg His Lys Ser Ala Cys Asp 
625                 630                 635                 640 


Arg Ser Cys Ile Ile Gly Leu Ala Val Leu Ala Ala Leu Val Leu Thr 
                645                 650                 655     


Ala Leu Ile Ala Val Val Val Val Leu Thr Ser Lys Arg Arg Arg Leu 
            660                 665                 670         


Ala Ala Val Val Ala Pro Val His Pro Lys Phe Lys Ser Thr Leu Asp 
        675                 680                 685             


Glu Asp Glu Glu Glu Ile Glu Thr Thr Asn Pro Leu Glu Leu Lys Glu 
    690                 695                 700                 


Glu Gln Arg Ala Arg Asp Met 
705                 710     


<210>  36
<211>  712
<212>  PRT
<213>  Trypanosoma cruzi

<400>  36

Met Ser Arg Phe Gln Arg Leu Leu Phe Ala Leu Phe Ala Gly Phe Leu 
1               5                   10                  15      


Phe Ser Phe Thr Ala Ser Val Val Val Ala Met Pro Leu Arg Tyr Met 
            20                  25                  30          


Val Glu Thr Val Ser Gly Ile Thr Gly Ser Ile Gly His Val Asn Gly 
        35                  40                  45              


Gly Pro Gly Thr Ser Leu Leu Thr Arg Pro Ser Ala Ile Cys Gln Gly 
    50                  55                  60                  


Arg Asn Glu Asp Glu Leu Leu Phe Gly Thr Gln Gly Tyr Phe Arg Asn 
65                  70                  75                  80  


Phe Ser Arg Ser Thr Lys Met Thr Gly Ile Leu Leu Gly Asp Gly Thr 
                85                  90                  95      


Val Gln Ile Leu Asp Gly Thr Trp Ser Gln Ala Arg Ile Asp Gly Pro 
            100                 105                 110         


Arg Gly Cys Val Arg Gly Ile Phe Asn Gln Lys Met Ile Val Tyr Phe 
        115                 120                 125             


Val Glu Gly Gln Ser Ser Leu Arg Tyr Phe Thr Ser Asn Tyr Val His 
    130                 135                 140                 


Thr Val Thr Ile Ser Ile Asn Leu Ser Phe Thr Asp Val Lys Leu Tyr 
145                 150                 155                 160 


Glu Gly Lys Leu Tyr Ile Thr Glu Gln Thr Lys Asp Glu Val Trp Gly 
                165                 170                 175     


Cys Asp Ile Asp Ala Asp Gly Ala Pro Val Ser Cys Ala Leu Lys Thr 
            180                 185                 190         


Gly Phe Lys Cys Asp Tyr Gly Lys Tyr His Gly Ile Thr Val Thr Lys 
        195                 200                 205             


Leu Gly Val Phe Val Val Gly Glu Ser Ala Ala Gly Ile Cys His Phe 
    210                 215                 220                 


Asp Met His Gly Asn Lys Ile Ser Val Leu Gly Gly Asn Tyr Ile Asp 
225                 230                 235                 240 


Val Phe Ser Leu Pro Ser Asp Glu Leu Tyr Ile Met Ser Tyr Thr Glu 
                245                 250                 255     


Leu Leu His Leu Arg Val Ile Gly Ser Ala Met Val Val Glu Lys Phe 
            260                 265                 270         


Ala Gly Arg Ser Asp Ala Thr Cys Pro Pro Leu Ile Asp Gly Tyr Asp 
        275                 280                 285             


Phe Thr Leu Cys Lys Asn Leu Arg Leu Phe Val Ile Glu Gln Ser Glu 
    290                 295                 300                 


Met Tyr Leu Ala Thr Thr Leu Asn Thr Val Arg Ser Val Thr Leu Pro 
305                 310                 315                 320 


Pro Ala Ile Val Trp Ile Glu Leu Pro Pro Pro Pro Leu Pro Ile Gly 
                325                 330                 335     


Tyr Pro Asn Asp Asn Glu Val Met Lys Lys Ile Ile Gln Leu Met Asn 
            340                 345                 350         


Glu Glu Leu Asn Lys His Leu Gly Thr Asn Gly Thr Tyr Val Ser Gln 
        355                 360                 365             


Glu Thr Met His Val Asp Ala Asn Thr Trp Ala Thr Lys Phe Ala Val 
    370                 375                 380                 


Met Val Gln Gln Gln Asp Phe Glu Asn Ala Thr Thr Pro Gly Glu Val 
385                 390                 395                 400 


Leu Thr Thr His Phe Ala Arg Thr Lys Gln Phe Val Lys Asp Tyr Tyr 
                405                 410                 415     


Asp Arg Val Asn Glu Val Leu Tyr Met Asp Thr Ser Ile Met Pro Phe 
            420                 425                 430         


Cys Asn Asp Thr Met Leu Asn Ala Val Met His Arg Leu Val Thr Val 
        435                 440                 445             


Val Arg Glu Val Leu Ser Phe Pro Leu Ile Tyr Ala Asn Pro Pro Glu 
    450                 455                 460                 


Val Arg Lys Glu Phe Asp Phe Glu Asn Ile Thr Thr Met Lys Leu Leu 
465                 470                 475                 480 


Met Pro Ala Ser Phe Asn Asn Asp Thr Thr Arg Glu Ala Leu Met Asp 
                485                 490                 495     


Ala Asp Met Asp Ala Ala Leu Leu Gln Ile Leu Arg Glu Leu Tyr Gly 
            500                 505                 510         


Pro Glu His Val Val Thr Leu Val Phe Pro Met Pro Gln Tyr Asp Phe 
        515                 520                 525             


Ser Lys Leu Thr Asp Glu Gln Leu Val Glu Val Arg Trp Phe Ile Leu 
    530                 535                 540                 


Asp Leu Val Arg Ala Arg Leu Glu Glu Cys Ala Val Leu Ser Val Asp 
545                 550                 555                 560 


Gly Val Gly Ala Ser Val Ser Ser His Ser Ser Val Cys Glu Ala Val 
                565                 570                 575     


Ile Thr Asn Arg Thr Glu Thr Val Val Ser His Pro Pro Phe Asn Ile 
            580                 585                 590         


Gln Ser Glu Tyr Glu Val Phe Val Pro Ser Arg Tyr Lys Phe Asn Ala 
        595                 600                 605             


Ser Leu Cys Leu Asp Gly Ile Asp Trp Thr Val Leu Glu Glu Leu Ile 
    610                 615                 620                 


Lys Asn Tyr Thr Glu Glu Asn Lys Pro Arg His Lys Ser Ala Cys Asp 
625                 630                 635                 640 


Arg Ser Cys Ile Ile Gly Leu Ala Val Leu Ala Ala Leu Val Leu Thr 
                645                 650                 655     


Ala Leu Ile Ala Val Met Val Val Leu Thr Ser Lys Arg Arg Arg Leu 
            660                 665                 670         


Ala Ala Val Val Ala Pro Val His Pro Lys Phe Lys Ser Thr Leu Asp 
        675                 680                 685             


Glu Asp Glu Glu Glu Met Glu Thr Thr Asn Pro Leu Glu Val Lys Asp 
    690                 695                 700                 


Glu Gln Arg Ala Arg Asp Met Tyr 
705                 710         


<210>  37
<211>  712
<212>  PRT
<213>  Trypanosoma cruzi

<400>  37

Met Phe Trp Phe Gln Ser Leu Leu Phe Ala Leu Phe Ala Gly Leu Leu 
1               5                   10                  15      


Phe Ser Phe Thr Ser Ser Val Val Val Ala Met Pro Leu Arg Tyr Met 
            20                  25                  30          


Val Glu Thr Val Ser Gly Ile Thr Gly Ser Ile Gly His Ala Asn Gly 
        35                  40                  45              


Gly Pro Gly Thr Ser Leu Leu Thr Arg Pro Ser Ala Ile Cys Gln Gly 
    50                  55                  60                  


Arg Asn Glu Asp Glu Leu Leu Phe Gly Thr Gln Gly Tyr Phe Arg Asn 
65                  70                  75                  80  


Phe Ser Arg Ser Thr Lys Met Thr Gly Ile Leu Ile Gly Asp Gly Thr 
                85                  90                  95      


Ala Gln Ile Leu Asp Gly Thr Trp Ser Gln Ala Arg Ile Asp Gly Pro 
            100                 105                 110         


Arg Gly Cys Val Arg Gly Ile Phe Ser Gln Lys Met Ile Val Tyr Phe 
        115                 120                 125             


Val Glu Gly Gln Ser Ser Leu Arg Tyr Phe Thr Ser Asp Tyr Val His 
    130                 135                 140                 


Thr Val Met Ile Ser Ile Asn Leu Phe Phe Thr Asp Val Lys Leu Tyr 
145                 150                 155                 160 


Glu Gly Lys Leu Tyr Met Thr Glu Gln Thr Lys Asp Glu Val Trp Gly 
                165                 170                 175     


Cys Asp Ile Asp Ala Asp Gly Ala Pro Val Ser Cys Ala Leu Lys Thr 
            180                 185                 190         


Gly Phe Lys Cys Asp Tyr Gly Lys Tyr His Gly Ile Thr Val Thr Lys 
        195                 200                 205             


Gln Gly Val Phe Val Val Gly Glu Ser Ala Ala Gly Ile Cys His Phe 
    210                 215                 220                 


Asp Met His Gly Asn Lys Leu Ser Val Leu Gly Gly Asn Tyr Ile Asp 
225                 230                 235                 240 


Val Phe Ser Leu Pro Ser Asp Glu Leu Tyr Ile Met Ser Tyr Thr Glu 
                245                 250                 255     


Leu Phe His Leu Arg Val Ile Gly Ser Ala Met Val Val Glu Lys Phe 
            260                 265                 270         


Ala Gly Arg Ala Asp Ala Thr Cys Pro Pro Leu Ile Asp Gly Tyr Asp 
        275                 280                 285             


Phe Thr Leu Cys Lys Asn Leu Arg Leu Phe Val Ile Asp Gln Ser Glu 
    290                 295                 300                 


Met Tyr Leu Ala Thr Thr Leu Asn Thr Val Arg Ser Val Thr Leu Pro 
305                 310                 315                 320 


Pro Ala Ile Val Trp Met Glu Leu Pro Pro Pro Pro Leu Pro Ile Gly 
                325                 330                 335     


Tyr Pro Asp Asp Asn Glu Val Met Lys Arg Ile Ile Gln Leu Met Asn 
            340                 345                 350         


Glu Glu Leu Asn Glu His Leu Arg Thr Asn Gly Thr Tyr Val Ser Gln 
        355                 360                 365             


Glu Asn Met His Val Asp Ala Asp Thr Trp Ala Thr Lys Phe Ala Val 
    370                 375                 380                 


Met Val Gln Gln His Asp Phe Glu Asn Ala Thr Thr Pro Gly Glu Val 
385                 390                 395                 400 


Leu Thr Thr His Phe Ala Gln Thr Thr Gln Phe Val Lys Asp Tyr Tyr 
                405                 410                 415     


Asp Arg Val Asp Glu Val Leu Tyr Met Asp Thr Ser Ile Met Pro Phe 
            420                 425                 430         


Cys Asn Asp Thr Met Leu Asn Ala Val Met His Arg Leu Val Ser Val 
        435                 440                 445             


Val Arg Glu Val Leu Gly Phe Pro Leu Ile Tyr Ala Asn Pro Pro Glu 
    450                 455                 460                 


Ala Arg Lys Glu Leu Asn Phe Glu Asn Ile Thr Thr Met Lys Leu Leu 
465                 470                 475                 480 


Met Pro Ala Ser Phe Asn Asn Asp Thr Thr Arg Asp Ala Leu Met Asp 
                485                 490                 495     


Ala Asp Met Asp Ala Ala Leu Leu Gln Ile Leu Arg Glu Leu Tyr Gly 
            500                 505                 510         


Pro Glu Asn Val Val Thr Leu Val Phe Pro Met Pro Gln Tyr Asp Phe 
        515                 520                 525             


Ser Lys Leu Thr Asp Glu Gln Leu Val Glu Val Arg Trp Phe Ile Leu 
    530                 535                 540                 


Asp Leu Val Arg Ala Arg Leu Glu Glu Cys Asp Val Leu Ser Ala Ser 
545                 550                 555                 560 


Ser Val Asp Ala Ser Val Ser Ser His Ser Gly Val Cys Glu Ala Val 
                565                 570                 575     


Ile Thr Asn Arg Thr Glu Thr Val Val Ser His Pro Pro Phe Asn Val 
            580                 585                 590         


Gln Ser Glu Tyr Glu Val Phe Val Pro Leu Arg Tyr Lys Phe Asn Ala 
        595                 600                 605             


Ser Leu Cys Leu Asp Gly Ile Asp Trp Ala Val Leu Glu Glu Ile Ile 
    610                 615                 620                 


Lys Asn Tyr Thr Glu Glu Asn Lys Pro Arg Arg Lys Ser Ala Cys Asp 
625                 630                 635                 640 


Arg Ser Cys Ile Ile Gly Leu Ala Val Leu Ala Ala Leu Val Leu Thr 
                645                 650                 655     


Ala Leu Ile Ala Val Val Val Val Leu Thr Ser Lys Arg Arg Arg Leu 
            660                 665                 670         


Ala Ala Val Val Ala Pro Val His Pro Lys Phe Lys Ser Thr Leu Asp 
        675                 680                 685             


Glu Asp Glu Glu Glu Ile Glu Thr Thr Asn Pro Leu Glu Val Lys Asp 
    690                 695                 700                 


Glu Gln Arg Ala Arg Asp Met Tyr 
705                 710         


<210>  38
<211>  342
<212>  PRT
<213>  Trypanosoma cruzi

<400>  38

Met His Val Asp Ala Asn Thr Trp Ala Thr Lys Phe Ala Val Met Val 
1               5                   10                  15      


Gln Gln Gln Asp Phe Glu Asn Ala Thr Thr Pro Gly Glu Val Leu Thr 
            20                  25                  30          


Thr His Phe Thr Arg Thr Lys Gln Phe Val Lys Asp Tyr Tyr Asp Arg 
        35                  40                  45              


Val Asn Glu Val Leu Tyr Met Asp Thr Ser Ile Met Pro Phe Cys Asn 
    50                  55                  60                  


Asp Thr Met Leu Asn Ala Val Met His Arg Leu Val Ser Val Val Arg 
65                  70                  75                  80  


Glu Val Leu Ser Phe Pro Leu Ile Tyr Ala Asn Pro Pro Glu Val Arg 
                85                  90                  95      


Lys Glu Phe Asp Phe Glu Asn Ile Thr Thr Met Lys Leu Leu Met Pro 
            100                 105                 110         


Ala Ser Phe Asn Asn Asp Thr Thr Arg Glu Ala Leu Met Asp Ala Asp 
        115                 120                 125             


Met Asp Ala Ala Leu Leu Gln Ile Leu Arg Glu Leu Tyr Gly Pro Glu 
    130                 135                 140                 


His Val Val Thr Leu Val Phe Pro Met Pro Gln Tyr Asp Phe Ser Lys 
145                 150                 155                 160 


Leu Thr Asp Glu Gln Leu Val Glu Val Arg Trp Phe Ile Leu Asp Leu 
                165                 170                 175     


Val Arg Ala Arg Leu Glu Glu Cys Ala Val Leu Ser Val Asp Gly Val 
            180                 185                 190         


Gly Ala Ser Val Ser Ser His Ser Ser Val Cys Glu Ala Val Ile Thr 
        195                 200                 205             


Asn Arg Thr Glu Thr Val Val Ser His Pro Pro Phe Asn Ile Gln Ser 
    210                 215                 220                 


Glu Tyr Glu Val Phe Val Pro Ser Arg Tyr Lys Phe Asn Ala Ser Leu 
225                 230                 235                 240 


Cys Leu Asp Gly Ile Asp Trp Ala Val Leu Glu Glu Leu Ile Lys Asn 
                245                 250                 255     


Tyr Thr Glu Glu Asn Lys Pro Arg His Lys Ser Ala Cys Asp Arg Ser 
            260                 265                 270         


Cys Ile Ile Gly Leu Ala Val Leu Ala Ala Leu Val Leu Thr Ala Leu 
        275                 280                 285             


Ile Ala Val Met Val Val Leu Thr Ser Lys Arg Arg Arg Leu Ala Ala 
    290                 295                 300                 


Val Val Ala Pro Val His Pro Lys Ile Lys Ser Thr Leu Asp Glu Asp 
305                 310                 315                 320 


Glu Glu Glu Met Glu Thr Thr Asn Pro Leu Glu Val Lys Asp Glu Gln 
                325                 330                 335     


Arg Ala Arg Asp Met Tyr 
            340         


<210>  39
<211>  712
<212>  PRT
<213>  Trypanosoma cruzi

<400>  39

Met Ser Arg Phe Gln Ser Leu Leu Phe Ala Leu Phe Ala Gly Phe Leu 
1               5                   10                  15      


Phe Ser Phe Thr Ala Ser Val Val Val Ala Met Pro Leu Arg Tyr Met 
            20                  25                  30          


Val Glu Thr Val Ser Gly Ile Thr Gly Ser Ile Gly His Val Asn Gly 
        35                  40                  45              


Gly Pro Gly Thr Ser Leu Leu Thr Arg Pro Ser Ala Ile Cys Gln Gly 
    50                  55                  60                  


Arg Asn Glu Asp Glu Leu Leu Phe Gly Thr Gln Gly Tyr Phe Arg Asn 
65                  70                  75                  80  


Phe Ser Arg Ser Thr Lys Met Thr Gly Ile Leu Leu Gly Asp Gly Thr 
                85                  90                  95      


Ala Gln Ile Leu Asp Gly Thr Trp Ser Gln Ala Arg Ile Asp Gly Pro 
            100                 105                 110         


Arg Gly Cys Val Arg Gly Ile Phe Asn Gln Lys Met Ile Val Tyr Phe 
        115                 120                 125             


Val Glu Gly Gln Ser Ser Leu Arg Tyr Phe Thr Ser Asn Tyr Val His 
    130                 135                 140                 


Thr Val Thr Ile Ser Ile Asn Leu Ser Phe Thr Asp Val Lys Leu Tyr 
145                 150                 155                 160 


Glu Gly Lys Leu Tyr Ile Thr Glu Gln Thr Lys Asp Glu Val Trp Gly 
                165                 170                 175     


Cys Asp Ile Asp Ala Asp Gly Ala Pro Val Ser Cys Ala Leu Lys Thr 
            180                 185                 190         


Gly Phe Lys Cys Asp Tyr Gly Lys Tyr His Gly Ile Thr Val Thr Lys 
        195                 200                 205             


Leu Gly Val Phe Val Val Gly Glu Ser Ala Ala Gly Ile Cys His Phe 
    210                 215                 220                 


Asp Met His Gly Asn Lys Ile Ser Val Leu Gly Gly Asn Tyr Ile Asp 
225                 230                 235                 240 


Val Phe Ser Leu Pro Ser Asp Glu Leu Tyr Ile Met Ser Tyr Thr Glu 
                245                 250                 255     


Leu Leu His Leu Arg Val Ile Gly Ser Ala Met Val Val Glu Lys Phe 
            260                 265                 270         


Ala Gly Arg Ser Asp Ala Thr Cys Pro Pro Leu Thr Asp Gly Tyr Asp 
        275                 280                 285             


Phe Thr Leu Cys Lys Asn Leu Arg Leu Phe Val Ile Glu Gln Ser Glu 
    290                 295                 300                 


Met Tyr Leu Ala Thr Thr Leu Asn Thr Val Arg Ser Val Thr Leu Pro 
305                 310                 315                 320 


Pro Ala Ile Val Trp Ile Glu Leu Pro Pro Pro Pro Leu Pro Ile Gly 
                325                 330                 335     


Tyr Pro Asn Asp Asn Glu Val Met Lys Lys Ile Ile Gln Leu Met Asn 
            340                 345                 350         


Glu Glu Leu Asn Lys His Leu Gly Thr Asn Gly Thr Tyr Val Ser Gln 
        355                 360                 365             


Glu Thr Met His Val Asp Ala Asn Thr Trp Ala Thr Lys Phe Ala Val 
    370                 375                 380                 


Met Val Gln Gln Gln Asp Phe Glu Asn Ala Thr Thr Pro Gly Glu Val 
385                 390                 395                 400 


Leu Thr Thr His Phe Thr Arg Thr Lys Gln Phe Val Lys Asp Tyr Tyr 
                405                 410                 415     


Asp Arg Val Asn Glu Val Leu Tyr Met Asp Thr Ser Ile Met Pro Phe 
            420                 425                 430         


Cys Asn Asp Thr Met Leu Asn Ala Val Met His Arg Leu Val Ser Val 
        435                 440                 445             


Val Arg Glu Val Leu Ser Phe Pro Leu Ile Tyr Ala Asn Pro Pro Glu 
    450                 455                 460                 


Val Arg Lys Glu Phe Asp Phe Glu Asn Ile Thr Thr Met Lys Leu Leu 
465                 470                 475                 480 


Met Pro Ala Ser Phe Asn Asn Asp Thr Thr Arg Glu Ala Leu Met Asp 
                485                 490                 495     


Ala Asp Met Asp Ala Ala Leu Leu Gln Ile Leu Arg Glu Leu Tyr Gly 
            500                 505                 510         


Pro Glu His Val Val Thr Leu Val Phe Pro Met Pro Gln Tyr Asp Phe 
        515                 520                 525             


Ser Lys Leu Thr Asp Glu Gln Leu Val Glu Val Arg Trp Phe Ile Leu 
    530                 535                 540                 


Asp Leu Val Arg Ala Arg Leu Glu Glu Cys Ala Val Leu Ser Val Asp 
545                 550                 555                 560 


Gly Val Gly Ala Ser Val Ser Ser His Ser Ser Val Cys Glu Ala Val 
                565                 570                 575     


Ile Thr Asn Arg Thr Glu Thr Val Val Ser His Pro Pro Phe Asn Ile 
            580                 585                 590         


Gln Ser Glu Tyr Glu Val Phe Val Pro Ser Arg Tyr Lys Phe Asn Ala 
        595                 600                 605             


Ser Leu Cys Leu Asp Gly Ile Asp Trp Ala Val Leu Glu Glu Leu Ile 
    610                 615                 620                 


Lys Asn Tyr Thr Glu Glu Asn Lys Pro Arg His Lys Ser Ala Cys Asp 
625                 630                 635                 640 


Arg Ser Cys Ile Ile Gly Leu Ala Val Leu Ala Ala Leu Val Leu Thr 
                645                 650                 655     


Ala Leu Ile Ala Val Met Val Val Leu Thr Ser Lys Arg Arg Arg Leu 
            660                 665                 670         


Ala Ala Val Val Ala Pro Val His Pro Lys Ile Lys Ser Thr Leu Asp 
        675                 680                 685             


Glu Asp Glu Glu Glu Met Glu Thr Thr Asn Pro Leu Glu Val Lys Asp 
    690                 695                 700                 


Glu Gln Arg Ala Arg Asp Met Tyr 
705                 710         


<210>  40
<211>  599
<212>  PRT
<213>  Trypanosoma cruzi

<400>  40

Gln Gly Ile Ile Asn Asp Lys Thr Ile Ile Tyr Phe Val Glu Gly Gln 
1               5                   10                  15      


Ser Ser Leu Arg Tyr Ile Thr Ala Asp Tyr Val His Thr Val Thr Ile 
            20                  25                  30          


Ser Thr Lys Leu Ser Phe Thr Asp Val Lys Leu Tyr Gly Gly Lys Leu 
        35                  40                  45              


Tyr Met Thr Glu Gln Thr Lys Asp Glu Ile Trp Val Cys Asp Ile Asp 
    50                  55                  60                  


Met Asn Gly Val Pro Val Thr Cys Val Leu Gln Asn Gly Phe Lys Cys 
65                  70                  75                  80  


Asp Tyr Gly Lys Tyr His Gly Ile Thr Val Thr Lys Leu Gly Val Phe 
                85                  90                  95      


Val Val Gly Glu Ser Ala Ser Gly Ile Cys His Phe Asp Met His Gly 
            100                 105                 110         


Asn Lys Ile Ser Val Leu Gly Gly Asn Tyr Val Asp Val Tyr Ser Leu 
        115                 120                 125             


Pro Thr Asp Thr Leu Phe Val Met Ser Phe Thr Glu Leu Leu His Leu 
    130                 135                 140                 


Arg Val Val Gly Ser Met Met Val Val Glu Lys Phe Ala Gly Arg Val 
145                 150                 155                 160 


Asp Ala Thr Cys Pro Pro Leu Leu Asp Gly Tyr Asp Phe Thr Leu Cys 
                165                 170                 175     


Met Asn Leu Arg Leu Phe Val Ile Asp Gln Asn Glu Met Tyr Leu Ala 
            180                 185                 190         


Thr Lys Leu Asn Thr Val Arg Ser Ile Thr Leu Pro Pro Val Val Val 
        195                 200                 205             


Trp Met Glu Leu Pro Pro Pro Pro Phe Pro Leu Gly Phe Pro Asp Asp 
    210                 215                 220                 


Asp Glu Lys Lys Glu Asn Val Met His Lys Ile Ile Gln Leu Met Asn 
225                 230                 235                 240 


Glu Glu Leu Asn Ala His Leu Arg Thr Gln Gly Thr Tyr Val Ser Leu 
                245                 250                 255     


Glu Thr Met Gln Val Asn Asp Asp Thr Trp Asn Thr Lys Phe Ala Val 
            260                 265                 270         


Met Val Gln Gln Gln Asp Phe Glu Ser Ala Thr Thr Pro Ala Glu Val 
        275                 280                 285             


Leu Ser Thr Asp Phe Val Gln Thr Lys Lys Phe Ile Met Asp Tyr Tyr 
    290                 295                 300                 


Asn Arg Val Asn Glu Val Leu Tyr Met Asp Thr Ser Ile Ile Pro Phe 
305                 310                 315                 320 


Cys Asp Gln Thr Met Leu Leu Gln Met Met His Lys Leu Val Ala Ile 
                325                 330                 335     


Val Arg Asn Val Leu Gly Phe Pro Leu Ile Tyr Ala Asn Pro Pro Glu 
            340                 345                 350         


Ala Leu Lys Asp Phe His Ile Glu Asn Ile Thr Ile Met Lys Leu Leu 
        355                 360                 365             


Met Pro Ala Ser Phe Asn Asn Asp Thr Thr Arg Asp Ala Leu Met Asp 
    370                 375                 380                 


Thr Asp Met Asp Ala Ala Leu Leu Gln Val Leu Arg Glu Leu Tyr Gly 
385                 390                 395                 400 


Pro Asp His Val Val Thr Leu Ile Phe Pro Met Pro Lys Tyr Glu Phe 
                405                 410                 415     


Ser Lys Leu Thr Asp Glu Gln Leu Ile Gln Val Arg Trp Phe Ile Leu 
            420                 425                 430         


Asp Leu Val Arg Ala Arg Leu Ala Glu Cys Glu Ile Leu Ser Val Asp 
        435                 440                 445             


Ser Met Asp Thr Ser Ser Gln Gly Thr Met Cys Glu Ala Thr Ile Thr 
    450                 455                 460                 


Asn Arg Thr Glu Thr Val Val Pro Thr Pro Pro Phe Asn Leu Gln Ser 
465                 470                 475                 480 


Glu Tyr Glu Val Phe Val Pro Ser Arg Tyr Lys Phe Asn Val Ser Val 
                485                 490                 495     


Cys Leu Asp Gly Ile Asp Trp Val Ala Leu Glu Glu Leu Ile Ala Asn 
            500                 505                 510         


Tyr Thr Glu Glu Asn Lys Pro Arg His Lys Ser Ala Cys Asp Arg Ser 
        515                 520                 525             


Cys Ile Ile Gly Leu Ala Val Leu Thr Ala Leu Val Leu Thr Ala Leu 
    530                 535                 540                 


Ile Ala Val Leu Val Val Leu Thr Ser Lys Arg Arg Arg Leu Ala Ala 
545                 550                 555                 560 


Val Val Ala Pro Val His Pro Lys Phe Lys Ser Thr Leu Asp Glu Glu 
                565                 570                 575     


Glu Glu Glu Glu Met Glu Thr Ser Asn Pro Leu Glu Val Lys Glu Glu 
            580                 585                 590         


Glu Arg Thr Arg Asp Thr Tyr 
        595                 


<210>  41
<211>  807
<212>  PRT
<213>  Trypanosoma evansi

<400>  41

Met Cys Phe Ile Phe Gly Val Glu Met Ser Asn Leu Ala Lys Arg Pro 
1               5                   10                  15      


Met Ser Leu Arg Lys Leu Pro Gln Leu Phe Leu Leu Ile Met Ile Gly 
            20                  25                  30          


Ile Ala Phe Val Ala Val Glu Cys Ile Gly Thr Pro Val Lys Leu Pro 
        35                  40                  45              


Arg Arg Val Asp Thr Val Ala Gly Gln Phe Gly Val Glu Gly Glu Thr 
    50                  55                  60                  


Asn Gly Tyr Pro Asn Thr Thr Arg Leu Thr Glu Pro Tyr Ala Leu Cys 
65                  70                  75                  80  


Arg Gly Arg Thr Asn Asp Glu Ile Leu Val Gly Ser Ser Asn Ser Phe 
                85                  90                  95      


Arg Asn Tyr Ser Arg Lys Thr Lys Glu Thr Gly Thr Tyr Leu Arg Tyr 
            100                 105                 110         


Asn Val Gly Asp Ser Val Ile Ser Gly Ser Ser Thr Ile Asn Lys Pro 
        115                 120                 125             


Arg Ser Cys Val Arg Arg Gly Ser Gly Asn His Thr Ile Ile Tyr Phe 
    130                 135                 140                 


Val Asp Asp Gln Lys Asp Ile Lys Tyr Ile Val Gly Asp Asp Val Ser 
145                 150                 155                 160 


Ser Phe Ser Val Pro Thr Arg Gly Ser Leu Asn Ala Val Ala Val His 
                165                 170                 175     


Glu Gly Ser Leu Tyr Val Thr Asp Gln Asn Asn Lys Ser Val Trp Lys 
            180                 185                 190         


Cys Gly Leu Gly Gly Ala Gly Lys Pro Gln Ser Cys Glu Glu Lys Lys 
        195                 200                 205             


Phe Thr Ser Val Thr Leu Asp Ala Lys Pro Glu Gly Ile Ala Val Thr 
    210                 215                 220                 


Ser Lys Gly Ile Phe Val Thr Ala Arg Asp Ser Ser Asn Lys Gly Ala 
225                 230                 235                 240 


Leu Leu Trp Leu Asp Met Ser Gly Ser Asn Arg Lys Gly Asn Val Ser 
                245                 250                 255     


Gly Gly Phe Val Asp Val Phe Ser Thr Glu Ser Gly Met Leu Tyr Ala 
            260                 265                 270         


Ala Thr Glu Lys Glu Leu Tyr Thr Val Thr Ala Thr Asp Thr Ser Leu 
        275                 280                 285             


Ser Val Thr Leu Phe Ala Gly Lys Asn Thr Ser Gln Cys Tyr Phe Pro 
    290                 295                 300                 


Thr Asn Gly Glu Asp Ile Val Leu Cys Asp Asn Ser Arg Leu Leu Val 
305                 310                 315                 320 


Ile Glu Glu Tyr Glu Met Tyr Val Thr Ser Arg Ala Lys His Thr Met 
                325                 330                 335     


Arg Ala Leu Thr Leu Pro Pro Val Asn Leu Thr Ala Ile Phe Arg Gly 
            340                 345                 350         


Arg Pro Ala Pro Val Gly Tyr Pro Asn Thr Thr Ile Met Glu Gln Phe 
        355                 360                 365             


Val Ala Ser Leu Thr Glu Asp Val Asn Lys Ala Leu Gly Thr Asn Asp 
    370                 375                 380                 


Ser Tyr Val Asp Pro Asp Ser Val Arg Val Asp Pro Asp Thr Trp Glu 
385                 390                 395                 400 


Thr Asn Tyr Thr Val Phe Val Gln Gln Thr Arg Phe Asp Asn Thr Thr 
                405                 410                 415     


Glu Glu Lys Leu Arg Ser Leu Thr Tyr Thr Gln Thr Asp Lys Thr Val 
            420                 425                 430         


Asp Glu Tyr Tyr Gly Leu Thr Asp Glu Tyr Val Tyr Ile Asp Thr Val 
        435                 440                 445             


Leu Val Pro Phe Cys Asp Asp Ala Ser Leu Val Thr Val Asp Gly Arg 
    450                 455                 460                 


Arg Ala Gly Tyr Ala Asp Lys Pro Ile Thr Phe Gly Ser Asp Val Ala 
465                 470                 475                 480 


Glu Asn Val Thr Ala Val Lys Leu Leu Met Pro His Ser Phe Lys Asn 
                485                 490                 495     


Ala Thr Thr Pro Lys Gln Leu Ser Ala Ala Asn Leu Thr Asp Phe Ala 
            500                 505                 510         


His Asn Leu Val Lys Asp Leu Arg Ala Ser Asp Thr Arg Val Asp Ile 
        515                 520                 525             


Thr Phe Pro Asp Pro Pro Phe Asn Phe Ser Ala Val Val Pro Glu Arg 
    530                 535                 540                 


Glu Gln Glu Val Arg Trp Phe Val His Gly Lys Val Met Lys Gln Leu 
545                 550                 555                 560 


Glu Ile Cys Glu Arg Leu Gly Ser Gln Gly Asp Ala Ala Val Ile Ala 
                565                 570                 575     


Ala Ala Ala Asp Ala Thr Ala Arg Gly Lys Ala Asn Val Thr Leu Asn 
            580                 585                 590         


Thr Ser Gly Val Lys Ala Asn Asp Thr Gly Val Gly Pro Asn Thr Thr 
        595                 600                 605             


Asn Thr Ala Gly Gly Ala Asn Thr Thr Ala Asn Val Ala Thr Asn Gly 
    610                 615                 620                 


Thr Ala Asn Val Ile Val Asn Pro Ser Thr Asn Ala Thr Pro Thr Gly 
625                 630                 635                 640 


Thr Thr Asn Ala Ser Val Thr Asn Thr Thr Glu Arg Ala Val Pro Val 
                645                 650                 655     


Val Ala Pro Thr Gln Pro Ser Asn Gly Tyr Ala Glu Cys Arg Ser Ala 
            660                 665                 670         


Ile Thr Asn Arg Thr Glu Thr Gln Asn Met Glu Pro Pro Tyr Asp Arg 
        675                 680                 685             


Lys His Arg Tyr Glu Val Phe Leu Pro Lys Lys Tyr Asp Phe Asn Val 
    690                 695                 700                 


Ser Trp Cys Val Asp Ile Ile Asp Trp Arg Asp Leu Asp Glu Met Leu 
705                 710                 715                 720 


Asn Asn Arg Thr Asp Glu Val Val Glu Lys Ser Leu Ser Trp Cys Gly 
                725                 730                 735     


His Gly Cys Ile Ile Ala Phe Ala Val Val Gly Ser Leu Ile Ala Ala 
            740                 745                 750         


Cys Leu Val Val Leu Ala Val Val Leu Thr Ser Lys Arg Arg Arg Leu 
        755                 760                 765             


Ala Ala Val Val Ala Pro Pro Arg Pro Lys Phe Val Ser Thr Val Glu 
    770                 775                 780                 


Asp Asp Glu Glu Asp Arg Val Ser Asn Ile Gly Met Pro Leu Thr Asp 
785                 790                 795                 800 


Gly Lys Gly Thr Thr Ala Pro 
                805         


<210>  42
<211>  818
<212>  PRT
<213>  Trypanosoma evansi

<400>  42

Met Cys Phe Ile Phe Gly Val Glu Met Ser Asn Leu Ala Lys Arg Pro 
1               5                   10                  15      


Met Ser Leu Arg Lys Leu Pro Gln Leu Leu Leu Leu Ile Met Ile Gly 
            20                  25                  30          


Ile Ala Phe Val Ala Val Glu Cys Ile Gly Ala Pro Val Lys Leu Pro 
        35                  40                  45              


Arg Arg Val Asp Thr Val Ala Gly Gln Phe Gly Phe Asp Gly Thr Thr 
    50                  55                  60                  


Asp Gly Ser Ser Asn Val Ser Met Leu Ser Ser Pro Tyr Ala Leu Cys 
65                  70                  75                  80  


Arg Gly Arg Thr Asn Asp Glu Ile Leu Val Gly Ser Ser Asn Ser Phe 
                85                  90                  95      


Arg Asn Tyr Ser Arg Lys Thr Lys Glu Thr Gly Thr Phe Leu Arg Gly 
            100                 105                 110         


Gly Pro Thr Gly Gly Leu Val Ser Ala Asp Ala Lys Ile Ser Lys Pro 
        115                 120                 125             


Arg Ser Cys Val Arg Arg Gly Ser Gly Asn His Thr Ile Ile Tyr Phe 
    130                 135                 140                 


Val Asp Asp Gln Asn Gly Leu Lys Tyr Ile Asn Asp Asn Glu Ile Gln 
145                 150                 155                 160 


His Val Thr Val Gly Asn Gly Leu Ser Leu Thr Ser Val Ala Ile Tyr 
                165                 170                 175     


Glu Lys Asp Leu Tyr Val Thr Asp Gln Asn Asn Lys Ser Val Trp Arg 
            180                 185                 190         


Cys Asn Val Gly Gly Ala Gly Lys Pro Gln Asn Cys Glu Glu Lys Lys 
        195                 200                 205             


Phe Thr Gly Leu Thr Phe Thr Ala Lys Pro Glu Gly Ile Ala Val Thr 
    210                 215                 220                 


Ser Lys Gly Ile Phe Val Ala Ala Arg Asp Ser Ser Asn Lys Gly Ala 
225                 230                 235                 240 


Leu Leu Trp Leu Asp Met Asn Gly Gly Gly Ser Lys Gly Asn Val Ser 
                245                 250                 255     


Gly Gly Phe Val Asp Val Phe Ser Thr Glu Ser Gly Met Leu Tyr Ala 
            260                 265                 270         


Ala Thr Glu Lys Glu Leu Tyr Thr Val Thr Ala Thr Asp Thr Ser Phe 
        275                 280                 285             


Ser Val Thr Ser Phe Ala Gly Lys Asn Thr Ser Ser Cys Tyr Ser His 
    290                 295                 300                 


Ala Asn Gly Glu Asp Ile Val Leu Cys Asp Asn Ser Arg Leu Leu Val 
305                 310                 315                 320 


Ile Glu Glu Tyr Glu Met Tyr Val Thr Ser Lys Glu Lys His Thr Met 
                325                 330                 335     


Arg Ala Leu Thr Leu Pro Pro Val Asn Leu Thr Ala Ile Phe Arg Gly 
            340                 345                 350         


Arg Pro Ala Pro Val Gly Tyr Pro Asn Thr Thr Ile Met Glu Gln Phe 
        355                 360                 365             


Val Ala Ser Leu Thr Glu Asp Val Asn Lys Ala Leu Gly Thr Asn Asp 
    370                 375                 380                 


Ser Tyr Val Asp Pro Asp Ser Val Arg Val Asp Pro Asp Thr Trp Glu 
385                 390                 395                 400 


Thr Asn Tyr Thr Val Phe Val Gln Gln Thr Arg Phe Asp Asn Thr Thr 
                405                 410                 415     


Glu Glu Lys Leu Arg Ser Leu Thr Tyr Thr Gln Thr Asp Lys Thr Val 
            420                 425                 430         


Asp Glu Tyr Tyr Gly Leu Thr Asp Glu Tyr Val Tyr Ile Asp Thr Val 
        435                 440                 445             


Leu Val Pro Phe Cys Asp Asp Ala Ser Leu Val Thr Ile Gln Arg Ala 
    450                 455                 460                 


Leu Ala Arg Glu Ala Gly Arg Ala Leu Asn Phe Ser Leu Ile Tyr Ala 
465                 470                 475                 480 


Asp Lys Pro Ile Thr Phe Gly Ser Asp Val Ala Glu Asn Val Thr Ala 
                485                 490                 495     


Val Lys Leu Leu Met Pro His Ser Phe Lys Asn Ala Thr Thr Pro Lys 
            500                 505                 510         


Gln Leu Ser Ala Ala Asn Leu Thr Asp Phe Ala His Asn Leu Val Lys 
        515                 520                 525             


Asp Leu Arg Ala Ser Asp Thr Arg Val Asp Ile Thr Phe Pro Asp Pro 
    530                 535                 540                 


Pro Phe Asn Phe Ser Ala Val Val Pro Glu Arg Glu Gln Glu Val Arg 
545                 550                 555                 560 


Trp Phe Val His Gly Lys Val Met Lys Gln Leu Glu Ile Cys Glu Arg 
                565                 570                 575     


Leu Gly Ser Gln Gly Asp Ala Ala Val Ile Ala Ala Ala Ala Asp Ala 
            580                 585                 590         


Thr Ala Arg Gly Lys Ala Asn Val Thr Leu Asn Thr Ser Gly Val Lys 
        595                 600                 605             


Ala Asn Asp Thr Gly Val Gly Pro Asn Thr Thr Asn Thr Ala Gly Gly 
    610                 615                 620                 


Ala Asn Thr Thr Ala Asn Val Val Ala Asn Gly Thr Ala Asn Val Ile 
625                 630                 635                 640 


Val Asn Pro Ser Thr Asn Ala Thr Pro Thr Gly Thr Ser Asn Ala Ser 
                645                 650                 655     


Val Thr Asn Thr Thr Glu Arg Ala Val Pro Val Val Ala Pro Thr Gln 
            660                 665                 670         


Pro Ser Asn Gly Tyr Ala Glu Cys Arg Ser Ala Ile Thr Asn Arg Thr 
        675                 680                 685             


Glu Thr Gln Asn Met Glu Pro Pro Tyr Asp Arg Lys His Arg Tyr Glu 
    690                 695                 700                 


Val Phe Leu Pro Lys Lys Tyr Asp Phe Asn Val Ser Trp Cys Val Asp 
705                 710                 715                 720 


Ile Ile Asp Trp Arg Asp Leu Asp Glu Met Leu Asn Asn Arg Thr Asp 
                725                 730                 735     


Glu Val Val Glu Lys Ser Leu Ser Trp Cys Gly His Gly Cys Ile Ile 
            740                 745                 750         


Ala Phe Ala Val Val Gly Ser Leu Ile Ala Ala Cys Leu Val Val Leu 
        755                 760                 765             


Ala Val Val Leu Thr Ser Lys Arg Arg Arg Leu Ala Ala Val Val Ala 
    770                 775                 780                 


Pro Pro Arg Pro Lys Phe Val Ser Thr Val Glu Asp Asp Glu Glu Asp 
785                 790                 795                 800 


Arg Val Ser Asn Ile Gly Val Pro Leu Thr Asp Gly Lys Gly Thr Thr 
                805                 810                 815     


Ala Pro 
        


<210>  43
<211>  750
<212>  PRT
<213>  Trypanosoma evansi

<400>  43

Met Pro Leu Trp Lys Gln Thr Asn Cys Glu Val Glu Thr Met Asn Val 
1               5                   10                  15      


Arg Glu Val Val Gly Thr Val His Leu Gly Tyr Val Ser Gln Met Leu 
            20                  25                  30          


Leu Leu Val Ala Thr Val Glu Thr Ile Val Val Arg Ser Gly Ala Ala 
        35                  40                  45              


Pro Ile Glu Leu Lys Arg His Val Thr Thr Val Ala Gly Lys Tyr Gly 
    50                  55                  60                  


His Ile Gly Asp Lys Asp Gly Phe Pro Gly Met Ser Glu Leu Ser Ser 
65                  70                  75                  80  


Pro His Ala Met Cys Arg Gly Arg Asn Ser Asp Glu Ile Leu Leu Gly 
                85                  90                  95      


Thr Val Asp Arg Phe Arg Ala Phe Ser Arg Lys Asn Arg Glu Thr Thr 
            100                 105                 110         


Thr Ile Thr Ala Trp Glu Thr Asp Glu Asp Gln Asn Ser Gly Ser Arg 
        115                 120                 125             


Ser Val Lys Val Asp Lys Pro Arg Ala Cys Val Gln Trp Thr Val Gly 
    130                 135                 140                 


Asp Ser Thr Phe Val Tyr Phe Val Glu Ser Met Gly Glu Val Lys Tyr 
145                 150                 155                 160 


Phe Lys Asp Ser Gly Val Phe Ser His Asp Val Val Arg Asn Gly Ser 
                165                 170                 175     


Leu Thr Gly Val Ala Leu Tyr Gly Asn His Leu Tyr Leu Thr Glu Gln 
            180                 185                 190         


Asn Thr Asn Thr Val Trp Thr Cys Glu Val Gly Ser Asp Gly Asp Pro 
        195                 200                 205             


Ile Ala Cys His Ser His Val Ala Leu Ser Ala Lys Cys Ser Ile Tyr 
    210                 215                 220                 


Gly Pro Ile Gly Ile Ala Ala Thr Gln Gln Gly Ile Phe Val Val Ala 
225                 230                 235                 240 


Arg Gly Pro Ala Lys Gln Gly Thr Ile Cys Trp Phe Asp Leu Gln Gly 
                245                 250                 255     


His Lys Ile Ala Glu Val Asp Gly Glu Tyr Val Asp Ile Thr Ser Thr 
            260                 265                 270         


Arg Ser Gly Asp Leu Leu Ala Ala Thr Gln Asn Glu Leu His Arg Val 
        275                 280                 285             


Ser Thr Asp Gly Asn Lys Leu Thr Thr Lys Arg Phe Ala Gly Gly Ser 
    290                 295                 300                 


Thr Asn Ser Cys Leu Pro Asn Thr Glu Gly Asp Asp Thr Leu Leu Cys 
305                 310                 315                 320 


Glu Ile Thr Arg Leu Leu Val Val Thr Glu Tyr Glu Met Tyr Val Thr 
                325                 330                 335     


Ser Glu Lys Lys Ser Val Leu Arg Ser Val Thr Leu Pro Pro Val Tyr 
            340                 345                 350         


Val Gln Gly Val Phe Pro Gly Arg Pro Leu Pro Val Gly Tyr Pro Asp 
        355                 360                 365             


Lys Asp Ile Met Glu Trp Ile Val Gly Asn Leu Thr Glu Asp Ile Asn 
    370                 375                 380                 


Thr Ala Leu Gly Thr Thr Glu Ser Ile Val Ala Ser Ser Ser Val His 
385                 390                 395                 400 


Val Asp Ser Thr Thr Trp Leu Thr Asn Phe Thr Ala Gly Val Gln Gln 
                405                 410                 415     


Pro Asp Phe Asp Asp Glu Lys Thr Glu Gln Ala Leu His Lys Ser Asn 
            420                 425                 430         


Tyr Glu His Thr Lys Glu Ala Ala Asp Glu Tyr Tyr Asn Leu Thr Asp 
        435                 440                 445             


Glu Gln Val Tyr Met Asp Ser Thr Met Val Pro Tyr Cys Asn Arg Leu 
    450                 455                 460                 


Ser Leu Asp Ala Leu Arg Arg Lys Leu Ala Lys Glu Ala Gly Glu Val 
465                 470                 475                 480 


Leu Asn Phe Thr Leu Ile Tyr Ala Asp Met Pro Leu Lys Ala Glu Ser 
                485                 490                 495     


Ser Asp Ala Gly Asn Ile Thr Thr Val Lys Leu Leu Met Pro Ala Ser 
            500                 505                 510         


Phe Asn Asn Thr Val Thr His Asp Leu Leu Ser Asp Ala Asn Leu Thr 
        515                 520                 525             


Glu Thr Ala His Ser Phe Ile Lys Tyr Leu Arg Ser Ser Asp Thr His 
    530                 535                 540                 


Val Asp Val Thr Phe Ser Asn Pro Pro Phe Asn Phe Ser Ser Leu Thr 
545                 550                 555                 560 


Pro Asp Glu Glu Gln Glu Val Arg Trp Tyr Ile His Asp Glu Val Met 
                565                 570                 575     


Asn Gln Ile Lys Lys Cys Glu Glu Arg Ser Thr Gly Arg Ser Met Ala 
            580                 585                 590         


Arg Arg Glu Glu Val Gly Asp Tyr Ser Arg Thr Thr Ile Ala Thr Ala 
        595                 600                 605             


Leu Asp Ser Asn Val Thr Gly Val Cys Gln Ser Thr Ile Thr Asn Arg 
    610                 615                 620                 


Thr Val Ser Leu Phe Tyr Gln Pro Pro Tyr Val Glu Met Ser Leu Tyr 
625                 630                 635                 640 


Glu Val Phe Ile Pro Gly Asn Tyr Thr Phe Asp Val Ser Glu Cys Val 
                645                 650                 655     


Gly Glu Ile Asp Trp Gln Asp Leu Asn Asp His Leu Asn Asn Asp Thr 
            660                 665                 670         


Val Arg Pro Thr Thr Glu Lys Ala Pro Lys Cys Gly Arg Val Cys Leu 
        675                 680                 685             


Ile Ile Ile Ala Val Val Cys Ala Leu Ile Val Ala Val Leu Ile Val 
    690                 695                 700                 


Leu Ala Val Val Phe Thr Ser Lys Arg Arg Arg Leu Ala Ala Val Val 
705                 710                 715                 720 


Ala Pro Ala Arg Pro Lys Phe Val Ser Thr Leu Asp Glu Asp Glu Gln 
                725                 730                 735     


Asp Tyr Ala Ser Ala Tyr Gly Asn Lys Glu Arg Val Glu Gln 
            740                 745                 750 


<210>  44
<211>  750
<212>  PRT
<213>  Trypanosoma evansi

<400>  44

Met Pro Leu Trp Lys Gln Thr Asn Cys Glu Val Glu Thr Met Asn Val 
1               5                   10                  15      


Arg Glu Val Val Gly Thr Val His Leu Gly Tyr Val Ser Gln Met Leu 
            20                  25                  30          


Leu Leu Val Ala Thr Val Glu Thr Ile Val Val Arg Ser Gly Ala Ala 
        35                  40                  45              


Pro Ile Glu Leu Lys Arg His Val Thr Thr Val Ala Gly Lys Tyr Gly 
    50                  55                  60                  


His Ile Gly Asp Lys Asp Gly Phe Pro Gly Met Ser Glu Leu Ser Ser 
65                  70                  75                  80  


Pro His Ala Met Cys Arg Gly Arg Asn Ser Asp Glu Ile Leu Leu Gly 
                85                  90                  95      


Thr Val Asp Arg Phe Arg Ala Phe Ser Arg Lys Asn Arg Glu Thr Thr 
            100                 105                 110         


Thr Ile Thr Ala Trp Glu Thr Asp Glu Asp Gln Asn Ser Gly Ser Arg 
        115                 120                 125             


Ser Val Lys Val Asp Lys Pro Arg Ala Cys Val Gln Trp Thr Val Gly 
    130                 135                 140                 


Asp Ser Thr Phe Val Tyr Phe Val Glu Ser Met Gly Glu Val Lys Tyr 
145                 150                 155                 160 


Phe Lys Asp Ser Gly Val Phe Ser His Asp Val Val Arg Asn Gly Ser 
                165                 170                 175     


Leu Thr Gly Val Ala Leu Tyr Gly Asn His Leu Tyr Leu Thr Glu Gln 
            180                 185                 190         


Asn Thr Asn Thr Val Trp Thr Cys Glu Val Gly Ser Asp Gly Asp Pro 
        195                 200                 205             


Ile Ala Cys His Ser His Val Ala Leu Ser Ala Lys Cys Ser Ile Tyr 
    210                 215                 220                 


Gly Pro Ile Gly Ile Ala Ala Thr Gln Gln Gly Ile Phe Val Val Ala 
225                 230                 235                 240 


Arg Gly Pro Ala Lys Gln Gly Thr Ile Cys Trp Phe Asp Leu Gln Gly 
                245                 250                 255     


His Lys Ile Ala Glu Val Asp Gly Glu Tyr Val Asp Ile Thr Ser Thr 
            260                 265                 270         


Arg Ser Gly Asp Leu Leu Ala Ala Thr Gln Asn Glu Leu His Arg Val 
        275                 280                 285             


Ser Thr Asp Gly Asn Lys Leu Thr Thr Lys Arg Phe Ala Gly Gly Ser 
    290                 295                 300                 


Thr Asn Ser Cys Leu Pro Asn Thr Glu Gly Asp Asp Thr Leu Leu Cys 
305                 310                 315                 320 


Glu Ile Thr Arg Leu Leu Val Val Thr Glu Tyr Glu Met Tyr Val Thr 
                325                 330                 335     


Ser Glu Lys Lys Ser Val Leu Arg Ser Val Thr Leu Pro Pro Val Tyr 
            340                 345                 350         


Val Gln Gly Val Phe Pro Gly Arg Pro Leu Pro Val Gly Tyr Pro Asp 
        355                 360                 365             


Lys Asp Ile Met Glu Trp Ile Val Gly Asn Leu Thr Glu Asp Ile Asn 
    370                 375                 380                 


Thr Ala Leu Gly Thr Thr Glu Ser Ile Val Ala Ser Ser Ser Val His 
385                 390                 395                 400 


Val Asp Ser Thr Thr Trp Leu Thr Asn Phe Thr Ala Gly Val Gln Gln 
                405                 410                 415     


Pro Asp Phe Asp Asp Glu Lys Thr Glu Gln Ala Leu His Lys Ser Asn 
            420                 425                 430         


Tyr Glu His Thr Lys Glu Ala Ala Asp Glu Tyr Tyr Asn Leu Thr Asp 
        435                 440                 445             


Glu Gln Val Tyr Met Asp Ser Thr Met Val Pro Tyr Cys Asn Arg Leu 
    450                 455                 460                 


Ser Leu Asp Ala Leu Arg Arg Lys Leu Ala Lys Glu Ala Gly Glu Val 
465                 470                 475                 480 


Leu Asn Phe Thr Leu Ile Tyr Ala Asp Met Pro Leu Lys Ala Glu Ser 
                485                 490                 495     


Ser Asp Ala Gly Asn Ile Thr Thr Val Lys Leu Leu Met Pro Ala Ser 
            500                 505                 510         


Phe Asn Asn Thr Val Thr His Asp Leu Leu Ser Asp Ala Asn Leu Thr 
        515                 520                 525             


Glu Thr Ala His Ser Phe Ile Lys Tyr Leu Arg Ser Ser Asp Thr His 
    530                 535                 540                 


Val Asp Val Thr Phe Ser Asn Pro Pro Phe Asn Phe Ser Ser Leu Thr 
545                 550                 555                 560 


Pro Asp Glu Glu Gln Glu Val Arg Trp Tyr Ile His Asp Glu Val Met 
                565                 570                 575     


Asn Gln Ile Lys Lys Cys Glu Glu Arg Ser Thr Gly Arg Ser Met Ala 
            580                 585                 590         


Arg Arg Glu Glu Val Gly Asp Tyr Ser Arg Thr Thr Ile Ala Thr Ala 
        595                 600                 605             


Leu Asp Ser Asn Val Thr Gly Val Cys Gln Ser Thr Ile Thr Asn Arg 
    610                 615                 620                 


Thr Val Ser Leu Phe Tyr Gln Pro Pro Tyr Val Glu Met Ser Leu Tyr 
625                 630                 635                 640 


Glu Val Phe Ile Pro Gly Asn Tyr Thr Phe Asp Val Ser Glu Cys Val 
                645                 650                 655     


Gly Glu Ile Asp Trp Gln Asp Leu Asn Asp His Leu Asn Asn Asp Thr 
            660                 665                 670         


Val Arg Pro Thr Thr Glu Lys Ala Pro Lys Cys Gly Arg Val Cys Leu 
        675                 680                 685             


Ile Ile Ile Ala Val Val Cys Ala Leu Ile Val Ala Val Leu Ile Val 
    690                 695                 700                 


Leu Ala Val Val Phe Thr Ser Lys Arg Arg Arg Leu Ala Ala Val Val 
705                 710                 715                 720 


Ala Pro Ala Arg Pro Lys Phe Val Ser Thr Leu Asp Glu Asp Glu Gln 
                725                 730                 735     


Asp Tyr Ala Ser Ala Tyr Gly Asn Lys Glu Arg Val Glu Gln 
            740                 745                 750 


<210>  45
<211>  756
<212>  PRT
<213>  Leishmania aethiopica

<400>  45

Met Gly Arg Cys Ile Arg Arg Val Pro Ala Ala Ala Ala Ala Ala Leu 
1               5                   10                  15      


Leu Leu Ala Leu Val Ala Ala Ala Ala Val Ser Thr Thr Thr Ala Arg 
            20                  25                  30          


Ala Tyr Asp His Ala Gly Ile Thr Val Ala Gly Ala Ile Met Val Gly 
        35                  40                  45              


Gln Asn Leu Gln Gly Lys Ala Gly Ala Ser Arg Ile Leu Asn Pro Phe 
    50                  55                  60                  


Ala Ile Cys Ala Asn Phe Asp Thr Ala Asp Val Glu Asp Thr Thr Leu 
65                  70                  75                  80  


Leu Ile Gly Gly Ala Ser Tyr Phe Phe Thr Leu Asn Arg Tyr Ser Thr 
                85                  90                  95      


Tyr Leu Gly Phe Trp Tyr Gly Gln Gly Ser Val Asn Leu Asn Ser Gly 
            100                 105                 110         


Pro Ile Asp Lys Val Arg Leu Thr Gly Val Phe Gly Cys Val Thr Leu 
        115                 120                 125             


Arg Pro Asn Ser Ser Asn Ser Leu Val Thr Ser Thr Val Tyr Tyr Val 
    130                 135                 140                 


Gln Asn Asp Gly Met Leu Tyr Trp Val Ser Asn Ser Val Val Tyr Leu 
145                 150                 155                 160 


Thr Pro Val Lys His Gly Ile Ser Phe Val Asp Val Thr Val His Asp 
                165                 170                 175     


Asn Asn Val Tyr Leu Leu Ser Thr Gln Asn His Ile Tyr Arg Cys Gly 
            180                 185                 190         


Ile Gly Ala Gly Gly Ala Val Val Gly Ser Ala Cys Thr Gln Ile Thr 
        195                 200                 205             


Leu Thr Gly Ser Thr Lys Phe Asp Gln Leu Ile Thr Thr Pro Ser Asp 
    210                 215                 220                 


Phe Arg Gly Phe Val Val Ser Ser Cys Gly Ile Phe Ile Ala Pro Asn 
225                 230                 235                 240 


Ser Asp Leu Tyr Trp Phe Asn Leu Ser Gly Val Phe Ile Ala Lys Ser 
                245                 250                 255     


Ala Gly Val Thr Phe Val Asp Ile Lys Leu Thr Ser Asn Arg Asp Thr 
            260                 265                 270         


Ala Asn Arg Gly Thr Pro Val Leu Met Ala Ala Ser Thr Ser Ala Val 
        275                 280                 285             


Tyr Ala Val Thr Ala Ser Ser Ala Thr Ile Ser Tyr Thr Leu Val Ser 
    290                 295                 300                 


Gly Lys Glu Thr Lys Ser Cys Asn Pro Ala Leu Asn Asn Val Asp Ser 
305                 310                 315                 320 


Asp Thr Ser Pro Thr Phe Cys Gly Ile Ala Arg Ile Tyr Pro Leu Ser 
                325                 330                 335     


Thr Asp Met Val Tyr Met Thr Thr Gly Gly Ala Ser Val Val Arg Ala 
            340                 345                 350         


Ile Ile Val Gly Asn Thr Thr Ile Ser Asp Thr Ile Thr Arg Thr Pro 
        355                 360                 365             


Phe Pro Val Tyr Phe Leu Asp Asn Pro Ser Ile Ile Pro Leu Ile Leu 
    370                 375                 380                 


Asp Gly Met Asn Tyr Glu Leu Val Gly Asn Ser Asn Ile Pro Phe Pro 
385                 390                 395                 400 


Tyr Val Ala Ile Asn His Ser Thr Pro Glu Val Asp Asp Gly Thr Trp 
                405                 410                 415     


Asp Thr Thr Phe Ser Val Asp Val Ser Asn Arg Phe Phe Ser Thr Val 
            420                 425                 430         


Ser Ser Ala Ala Val Val Ser Thr Pro Phe Met Gly Ser Leu His Gly 
        435                 440                 445             


Leu Gln Ala Tyr Tyr Asn Arg Thr Asn Gln Ile Leu Phe Gly Asp Pro 
    450                 455                 460                 


Asn Val Leu Pro Met Cys Asn Leu Thr Lys Met Gln Met Ile Glu Arg 
465                 470                 475                 480 


Ala Val Ala Ala Asp Ala Arg Ala Ala Leu Gln Tyr Pro Tyr Ile Tyr 
                485                 490                 495     


Thr Ser Lys Ala Gln Asn Phe Thr Val Asn Ala His Pro Asn Leu Thr 
            500                 505                 510         


Leu Leu Lys Leu Leu Met Pro Tyr Pro Phe Gly Glu Ile Leu Asn Glu 
        515                 520                 525             


Ser Gly Phe Phe Glu Asn Thr Thr Thr Pro Ala Ala Leu Ala Asn Val 
    530                 535                 540                 


His Phe Asn Thr Thr Met Leu Ala Ala Val Arg Asn Ala Tyr Thr Pro 
545                 550                 555                 560 


Asp Phe Val Tyr Asp Cys Ile Phe Ala Gly Asn Ala Phe Pro Phe His 
                565                 570                 575     


Ile Leu Thr Ala Ala Gln Gln Gln Leu Val Arg Trp Ile Ile Tyr Thr 
            580                 585                 590         


Ala Ile Gln Glu Gln Leu Ala Lys Cys Ala Glu Asn Ser Pro Ser Tyr 
        595                 600                 605             


Thr Gly Ser Asp Ser Ser Ser Ser Asp Ser His Asp Asp Met Val Pro 
    610                 615                 620                 


Gly Cys Val Pro Arg Val Gly Ile Gly Asn Leu Thr Glu Leu Val Met 
625                 630                 635                 640 


Pro Gly Met Pro Tyr Ser Asn Tyr Asn Ile Thr Val Phe Ile Pro Glu 
                645                 650                 655     


Gly Leu His Tyr Asn Phe Ser Ile Ser Arg Cys Leu Asp Gly Thr Asp 
            660                 665                 670         


Trp Thr Asn Val Thr Asp Tyr Leu Gln His Ala Thr Thr Pro Arg Thr 
        675                 680                 685             


Arg Gln Cys Gly Thr Gly Cys Ile Val Ser Ile Ala Val Val Ser Ala 
    690                 695                 700                 


Val Val Ala Ala Ile Leu Val Val Ala Ile Val Ile Ala Thr Ser Lys 
705                 710                 715                 720 


Arg Arg Arg Leu Ala Thr Val Val Ala Pro Ala Phe Thr Val Glu Pro 
                725                 730                 735     


Lys Phe Ala Ser Thr Leu Asp Met Ser Ser Glu Glu Gly Ser Arg Asn 
            740                 745                 750         


Pro Leu Asn Gly 
        755     


<210>  46
<211>  755
<212>  PRT
<213>  Leishmania amazonensis

<400>  46

Met Gly Arg Ser Ile Arg Arg Val Ser Ala Ala Ala Ala Ala Leu Leu 
1               5                   10                  15      


Met Ala Leu Val Ala Ala Ala Ala Val Ala Pro Thr Thr Ala Arg Ala 
            20                  25                  30          


Tyr Asp His Ala Gly Ile Thr Val Ala Gly Ala Leu Met Val Gly Gln 
        35                  40                  45              


Asn Leu Gln Gly Thr Ala Ala Thr Ser Arg Ile Leu Asn Pro Phe Ala 
    50                  55                  60                  


Ile Cys Ala Asn Phe Asp Thr Ala Asp Val Glu Asp Thr Thr Leu Leu 
65                  70                  75                  80  


Ile Gly Gly Ala Ser Tyr Phe Phe Thr Leu Asn Arg Tyr Ser Thr Tyr 
                85                  90                  95      


Leu Gly Phe Trp Tyr Gly Gln Gly Ser Met Asn Leu Asn Ser Gly Pro 
            100                 105                 110         


Ile Asp Lys Val Arg Leu Thr Gly Val Phe Gly Cys Val Thr Leu Arg 
        115                 120                 125             


Pro Asn Pro Ser Asn Gly Leu Pro Thr Ser Ile Val Tyr Tyr Val Gln 
    130                 135                 140                 


Asn Asp Gly Phe Leu Tyr Trp Val Ser Asn Ser Ile Val Tyr Leu Thr 
145                 150                 155                 160 


Gln Val Glu Ser Gly Ile Ser Leu Phe Asp Val Thr Val Tyr Asn Asn 
                165                 170                 175     


Ser Val Tyr Leu Leu Ser Ala Gln Asn Val Ile Tyr Arg Cys Gly Ile 
            180                 185                 190         


Gly Ala Gly Gly Ala Val Val Gly Ser Ala Cys Thr Gln Ile Leu Leu 
        195                 200                 205             


Thr Gly Ser Pro Ala Phe His Gln Leu Ile Ala Val Ser Ser Asp Phe 
    210                 215                 220                 


Arg Gly Phe Ala Val Ser Ala Ser Gly Ile Val Val Ala Pro Thr Ala 
225                 230                 235                 240 


Asp Leu Phe Trp Phe Asn Leu Ser Gly Ala Phe Ile Ser Lys Ser Ala 
                245                 250                 255     


Gly Val Thr Phe Val Asp Ala Lys Phe Thr Thr Asn Arg Asp Thr Ala 
            260                 265                 270         


Asn Arg Gly Ala Pro Val Leu Met Ala Ala Ser Thr Ser Ala Val Tyr 
        275                 280                 285             


Thr Val Ala Thr Ser Gly Pro Ser Ile Thr Tyr Thr Leu Val Ser Gly 
    290                 295                 300                 


Glu Glu Thr Gly Arg Cys Asn Pro Ala Leu Asn Asn Val Asp Ser Asp 
305                 310                 315                 320 


Thr Ser Pro Thr Phe Cys Gly Ile Ala Arg Ile Tyr Pro Leu Ser Thr 
                325                 330                 335     


Asp Met Val Tyr Met Thr Thr Gly Gly Ala Ser Val Val Arg Ala Ile 
            340                 345                 350         


Leu Val Gly Asn Thr Thr Val His Asp Thr Ile Thr Arg Thr Pro Phe 
        355                 360                 365             


Pro Val Tyr Phe Leu Asp Asn Ser Ser Ile Met Pro Leu Met Leu Asp 
    370                 375                 380                 


Gly Met Asn Tyr Glu Leu Val Ala Asn Ser Asp Ile Pro Phe Pro Tyr 
385                 390                 395                 400 


Val Ala Ile Asn Glu Phe Thr Pro Glu Val Gly Asp Ser Thr Trp Asp 
                405                 410                 415     


Thr Ser Phe Ser Val Asp Val Ser Asn Arg Phe Phe Ser Thr Ala Ser 
            420                 425                 430         


Ser Ala Ala Val Ile Ser Thr Pro Phe Met Gly Ser Leu His Gly Leu 
        435                 440                 445             


Gln Ala Tyr Tyr Asn Arg Thr Asn Gln Ile Leu Phe Gly Asp Pro Asn 
    450                 455                 460                 


Val Leu Pro Met Cys Asn Leu Thr Lys Met His Met Ile Glu Arg Ala 
465                 470                 475                 480 


Val Ala Ala Asp Ala Arg Ala Ala Leu Gln Tyr Pro Tyr Ile Tyr Thr 
                485                 490                 495     


Ser Arg Ala Gln Asn Phe Thr Val Asn Ala Gln Pro Asn Leu Thr Leu 
            500                 505                 510         


Leu Lys Leu Leu Met Pro Tyr Pro Phe Gly Glu Ile Leu Asn Glu Ser 
        515                 520                 525             


Gly Phe Phe Glu Asn Thr Thr Thr Pro Ala Ala Leu Ala Asn Val His 
    530                 535                 540                 


Phe Asn Lys Thr Met Leu Ala Ala Val Arg Asn Ala Tyr Ala Pro Asp 
545                 550                 555                 560 


Phe Val Tyr Asp Ser Ile Phe Ala Gly Asn Ala Phe Pro Phe His Ile 
                565                 570                 575     


Leu Thr Ala Ala Gln Gln Gln Val Val Arg Trp Val Ile Tyr Met Ala 
            580                 585                 590         


Ile Gln Glu Gln Leu Ala Lys Cys Ala Glu Asn Thr Pro Ser Tyr Pro 
        595                 600                 605             


Asp Ser Asp Ser Ser Ser Ser Asp Ser His Asp Asp Met Val Pro Gly 
    610                 615                 620                 


Cys Val Pro Arg Val Gly Ile Ser Asn Leu Thr Glu Gln Met Ile Pro 
625                 630                 635                 640 


Gly Leu Pro Tyr Ser Asn Phe Asn Ile Thr Phe Phe Ile Pro Glu Ser 
                645                 650                 655     


Leu His Tyr Thr Phe Ser Ile Ser Arg Cys Leu Asp Gly Thr Asp Trp 
            660                 665                 670         


Thr Asn Val Thr Asp Tyr Leu Gln Asn Ala Thr Ile Thr Ser Thr Arg 
        675                 680                 685             


Glu Cys Gly Thr Gly Cys Ile Val Ser Ile Ala Val Ala Ser Ala Val 
    690                 695                 700                 


Val Ala Ala Ile Leu Val Val Val Ile Val Ile Val Thr Ser Lys Arg 
705                 710                 715                 720 


Arg Arg Leu Ala Thr Val Val Ala Pro Ala Leu Thr Val Glu Pro Lys 
                725                 730                 735     


Phe Ala Ser Thr Leu Asp Val Thr Ser Glu Glu Gly Ser Arg Asn Pro 
            740                 745                 750         


Leu Asn Gly 
        755 


<210>  47
<211>  756
<212>  PRT
<213>  Leishmania braziliensis

<400>  47

Met Gly Arg Cys Val Tyr Arg Val Ser Ser Ala Ala Ala Thr Leu Leu 
1               5                   10                  15      


Thr Val Leu Ile Ala Ala Val Thr Val Ala Ala Thr Thr Ala Arg Ala 
            20                  25                  30          


Tyr Asp His Ala Gly Val Thr Val Ala Gly Ala Leu Leu Val Gly Gln 
        35                  40                  45              


Asn Glu Glu Gly Lys Leu Gly Thr Asn Arg Ile Leu Asn Pro Phe Ala 
    50                  55                  60                  


Leu Cys Ala Asn Phe Asp Thr Thr Asp Val Thr Asp Thr Thr Leu Leu 
65                  70                  75                  80  


Ile Gly Gly Ala Ser Tyr Phe Phe Thr Phe Asp Arg His Ser Thr Tyr 
                85                  90                  95      


Leu Ser Phe Trp Tyr Gly Gln Gly Ser Met Asn Leu Asn Ser Gly Pro 
            100                 105                 110         


Ile Asp Gln Val Arg Leu Thr Gly Val Phe Gly Cys Thr Thr Val Arg 
        115                 120                 125             


Thr Thr Ser Ser Ser Gly Ser Pro Ile Ser Ala Val Tyr Tyr Val Gln 
    130                 135                 140                 


Asn Asp Gly Phe Leu Tyr Trp Val Met Asn Ser Val Val Tyr Val Thr 
145                 150                 155                 160 


Leu Val Lys Asn Gly Ile Ser Leu Phe Asp Val Thr Val Tyr Lys Gly 
                165                 170                 175     


Asn Leu Tyr Leu Leu Ser Ala Gln Asn Arg Ile Tyr Lys Cys Leu Ile 
            180                 185                 190         


Gly Pro Gly Gly Ala Val Thr Gly Ser Ala Cys Thr Gln Val Met Leu 
        195                 200                 205             


Thr Gly Ser Thr Ala Tyr Ala Asn Leu Ser Glu Thr Ser Thr Ser Glu 
    210                 215                 220                 


Phe Lys Gly Phe Ala Val Ser Ser Ala Gly Ile Phe Ile Ala Pro Ser 
225                 230                 235                 240 


Ser Ser Leu Tyr Trp Phe Asn Leu Ala Gly Gly Tyr Ile Ala Ser Thr 
                245                 250                 255     


Thr Thr Ala Val Val Phe Val Asp Val Lys Phe Thr Ser Asn Arg Asp 
            260                 265                 270         


Thr Ala Asn Pro Gly Ile Pro Thr Leu Met Ala Ala Ser Thr Ser Ala 
        275                 280                 285             


Val Tyr Arg Val Ser Thr Ala Gly Thr Ser Ile Thr Tyr Thr Leu Ile 
    290                 295                 300                 


Ala Gly Lys Glu Thr Ala Thr Cys Asn Leu Ala Leu Asp Asn Val Asp 
305                 310                 315                 320 


Ser Leu Thr Asp Pro Ser Phe Cys Gly Ile Ala Arg Ile Tyr Pro Leu 
                325                 330                 335     


Ser Leu Asp Val Val Tyr Met Thr Thr Ala Gly Ala Ser Val Val Arg 
            340                 345                 350         


Ala Ile Val Val Ser Asn Thr Thr Ile Arg Asp Thr Ile Thr Arg Thr 
        355                 360                 365             


Pro Phe Pro Leu Tyr Phe Leu Asp Arg Ala Ser Thr Ile Pro Val Leu 
    370                 375                 380                 


Leu Asp Gly Met Asn Tyr Glu Ile Val Gly His Ser Asn Val Pro Phe 
385                 390                 395                 400 


Pro Tyr Val Ala Ile Asp Gln Ser Thr Pro Glu Val Asn Asp Thr Thr 
                405                 410                 415     


Trp Asp Thr Ser Phe Gly Val Asp Ile Ser Asn Arg Phe Phe Ser Met 
            420                 425                 430         


Ala Ser Ser Ala Ala Val Thr Ser Thr Pro Phe Met Gly Ser Leu His 
        435                 440                 445             


Gly Leu Glu Thr Tyr Tyr Asn Arg Thr Asn Gln Ile Ile Phe Gly Asp 
    450                 455                 460                 


Pro Asn Val Leu Pro Met Cys Asn Leu Thr Lys Met Leu Met Ile Glu 
465                 470                 475                 480 


Arg Ala Val Ala Thr Ala Ala Arg Ala Ala Leu Lys Tyr Pro Tyr Ile 
                485                 490                 495     


Tyr Thr Ser Asn Ala Gln Asn Phe Thr Val Asn Ala Gln Pro Asn Leu 
            500                 505                 510         


Thr Leu Val Lys Leu Leu Met Pro Tyr Ala Phe Gly Glu Ile Leu Asn 
        515                 520                 525             


Glu Leu Gly Phe Phe Glu Asn Thr Thr Thr Ala Ala Ala Leu Ala Ala 
    530                 535                 540                 


Val Gln Phe Asn Thr Thr Met Leu Ala Ala Val Arg Ser Ala Tyr Met 
545                 550                 555                 560 


Met Asp Arg Val Tyr Asp Cys Ile Phe Ser Gly Asn Ala Tyr Pro Phe 
                565                 570                 575     


His Val Leu Thr Ala Ala Gln Gln Gln Glu Val Arg Trp Ile Ile Tyr 
            580                 585                 590         


Ser Ala Ile Gln Asn Gln Leu Ala Arg Cys Asn Gln Ser Ile Pro Tyr 
        595                 600                 605             


Leu Val Pro Asp Ser Asn Ser Ser Asn Ser Tyr Asn Asn Met Ala Pro 
    610                 615                 620                 


Gly Cys Val Pro Arg Ile Gly Ile Asn Asn Leu Thr Glu Met Leu Leu 
625                 630                 635                 640 


Pro Gly Leu Pro Tyr Ser Asn Phe Asn Ile Thr Val Phe Ile Pro Glu 
                645                 650                 655     


Ser Leu Tyr Tyr Asn Phe Gly Ile Ser Arg Cys Leu Asp Gly Thr Asp 
            660                 665                 670         


Trp Thr Asp Val Met Gly Tyr Leu Ile Asn Ala Thr Thr Arg Asn Asn 
        675                 680                 685             


Arg Lys Cys Asn Thr Gly Cys Ile Val Gly Ile Ala Val Ala Ser Ala 
    690                 695                 700                 


Leu Val Ala Ser Phe Leu Val Val Ala Ile Val Ile Met Thr Ser Lys 
705                 710                 715                 720 


Arg Arg Arg Leu Ala Thr Val Val Ala Pro Ala Ala Thr Ser Glu Pro 
                725                 730                 735     


Lys Phe Ile Ser Thr Leu Asp Met Thr Ser Glu Glu Gly Ser Arg Asn 
            740                 745                 750         


Pro Leu Thr Arg 
        755     


<210>  48
<211>  756
<212>  PRT
<213>  Leishmania braziliensis

<400>  48

Met Gly Arg Cys Val Tyr Arg Val Ser Ser Ala Ala Ala Thr Leu Leu 
1               5                   10                  15      


Thr Val Leu Ile Ala Ala Val Thr Val Ala Ala Thr Thr Ala Arg Ala 
            20                  25                  30          


Tyr Asp His Ala Gly Val Thr Val Ala Gly Ala Leu Leu Val Gly Gln 
        35                  40                  45              


Asn Glu Glu Gly Lys Leu Gly Thr Asn Arg Ile Leu Asn Pro Phe Ala 
    50                  55                  60                  


Leu Cys Ala Asn Phe Asp Thr Thr Asp Val Thr Asp Thr Thr Leu Leu 
65                  70                  75                  80  


Ile Gly Gly Ala Ser Tyr Phe Phe Thr Phe Asp Arg His Ser Thr Tyr 
                85                  90                  95      


Leu Ser Phe Trp Tyr Gly Gln Gly Ser Met Asn Leu Asn Ser Gly Pro 
            100                 105                 110         


Ile Asp Gln Val Arg Leu Thr Gly Val Phe Gly Cys Thr Thr Val Arg 
        115                 120                 125             


Thr Thr Ser Ser Ser Gly Ser Pro Ile Ser Thr Val Tyr Tyr Val Gln 
    130                 135                 140                 


Asn Asp Gly Phe Leu Tyr Trp Val Met Asn Ser Val Val Tyr Val Thr 
145                 150                 155                 160 


Leu Val Lys Asn Gly Ile Ser Leu Phe Asp Val Thr Val Tyr Lys Gly 
                165                 170                 175     


Asn Leu Tyr Leu Leu Ser Ala Gln Asn Arg Ile Tyr Lys Cys Leu Ile 
            180                 185                 190         


Gly Pro Gly Gly Ala Val Thr Gly Ser Ala Cys Thr Gln Val Met Leu 
        195                 200                 205             


Ala Gly Ser Thr Ala Tyr Ala Asn Leu Ser Glu Thr Ser Thr Ser Glu 
    210                 215                 220                 


Phe Lys Gly Phe Ala Val Ser Ser Ala Gly Ile Phe Ile Ala Pro Ser 
225                 230                 235                 240 


Ser Ser Leu Tyr Trp Phe Asn Leu Ala Gly Gly Tyr Ile Ala Ser Thr 
                245                 250                 255     


Thr Thr Ala Val Val Phe Val Asp Val Lys Phe Thr Ser Asn Arg Asp 
            260                 265                 270         


Thr Ala Asn Pro Gly Ile Pro Thr Leu Met Ala Ala Ser Thr Ser Ala 
        275                 280                 285             


Val Tyr Arg Val Ser Thr Ala Gly Thr Ser Ile Thr Tyr Thr Leu Ile 
    290                 295                 300                 


Ala Gly Lys Glu Thr Ala Thr Cys Asn Leu Ala Leu Asp Asn Val Asp 
305                 310                 315                 320 


Ser Leu Thr Asp Pro Ser Phe Cys Gly Ile Ala Arg Ile Tyr Pro Leu 
                325                 330                 335     


Ser Leu Asp Val Val Tyr Met Thr Thr Ala Gly Ala Ser Val Val Arg 
            340                 345                 350         


Ala Ile Val Val Ser Asn Thr Thr Ile Arg Asp Thr Ile Thr Arg Thr 
        355                 360                 365             


Pro Phe Pro Leu Tyr Phe Leu Asp Arg Ala Ser Thr Ile Pro Val Leu 
    370                 375                 380                 


Leu Asp Gly Met Asn Tyr Glu Ile Val Gly His Ser Asn Val Pro Phe 
385                 390                 395                 400 


Pro Tyr Val Ala Ile Asp Gln Ser Thr Pro Glu Val Asn Asp Thr Thr 
                405                 410                 415     


Trp Asp Thr Ser Phe Gly Val Asp Ile Ser Asn Arg Phe Phe Ser Met 
            420                 425                 430         


Ala Ser Ser Ala Ala Val Thr Ser Thr Pro Phe Met Gly Ser Leu His 
        435                 440                 445             


Gly Leu Glu Thr Tyr Tyr Asn Arg Thr Asn Gln Ile Ile Phe Gly Asp 
    450                 455                 460                 


Pro Asn Val Leu Pro Met Cys Asn Leu Thr Lys Met Leu Met Ile Glu 
465                 470                 475                 480 


Arg Ala Val Ala Thr Ala Ala Arg Ala Ala Leu Lys Tyr Pro Tyr Ile 
                485                 490                 495     


Tyr Thr Ser Asn Ala Gln Asn Phe Thr Val Asn Ala Gln Pro Asn Leu 
            500                 505                 510         


Thr Leu Val Lys Leu Leu Met Pro Tyr Ala Phe Gly Glu Ile Leu Asn 
        515                 520                 525             


Glu Leu Gly Phe Phe Glu Asn Thr Thr Thr Ala Ala Ala Leu Ala Ala 
    530                 535                 540                 


Val Gln Phe Asn Thr Thr Met Leu Ala Ala Val Arg Ser Ala Tyr Met 
545                 550                 555                 560 


Met Asp Arg Val Tyr Asp Cys Ile Phe Ser Gly Asn Ala Tyr Pro Phe 
                565                 570                 575     


His Val Leu Thr Ala Ala Gln Gln Gln Glu Val Arg Trp Ile Ile Tyr 
            580                 585                 590         


Ser Ala Ile Gln Asn Gln Leu Ala Arg Cys Asn Gln Ser Ile Pro Tyr 
        595                 600                 605             


Leu Gly Pro Asp Ser Asn Ser Ser Asn Ser Tyr Asn Asn Met Ala Pro 
    610                 615                 620                 


Gly Cys Val Pro Arg Ile Gly Ile Asn Asn Leu Thr Glu Met Leu Leu 
625                 630                 635                 640 


Pro Gly Leu Pro Tyr Ser Asn Phe Asn Ile Thr Val Phe Ile Pro Glu 
                645                 650                 655     


Ser Leu Tyr Tyr Asn Phe Gly Ile Ser Arg Cys Leu Asp Gly Thr Asp 
            660                 665                 670         


Trp Thr Asp Val Met Gly Tyr Leu Ile Asn Ala Thr Thr Arg Asn Asn 
        675                 680                 685             


Arg Lys Cys Asn Thr Gly Cys Ile Val Gly Ile Ala Val Ala Ser Ala 
    690                 695                 700                 


Leu Val Ala Ser Phe Leu Val Val Ala Ile Val Ile Met Thr Ser Lys 
705                 710                 715                 720 


Arg Arg Arg Leu Ala Thr Val Val Ala Pro Ala Ala Thr Ser Glu Pro 
                725                 730                 735     


Lys Phe Ile Ser Thr Leu Asp Met Thr Ser Glu Glu Gly Ser Arg Asn 
            740                 745                 750         


Pro Leu Thr Arg 
        755     


<210>  49
<211>  756
<212>  PRT
<213>  Leishmania braziliensis

<400>  49

Met Gly Arg Cys Val Tyr Arg Val Ser Ser Ala Ala Ala Thr Leu Leu 
1               5                   10                  15      


Thr Val Leu Ile Ala Ala Val Thr Val Ala Ala Thr Thr Ala Arg Ala 
            20                  25                  30          


Tyr Asp His Ala Gly Val Thr Val Ala Gly Ala Leu Leu Val Gly Gln 
        35                  40                  45              


Asn Glu Glu Gly Lys Leu Gly Thr Asn Arg Ile Leu Asn Pro Phe Ala 
    50                  55                  60                  


Leu Cys Ala Asn Phe Asp Thr Thr Asp Val Thr Asp Thr Thr Leu Leu 
65                  70                  75                  80  


Ile Gly Gly Ala Ser Tyr Phe Phe Thr Phe Asp Arg His Ser Thr Tyr 
                85                  90                  95      


Leu Ser Phe Trp Tyr Gly Gln Gly Ser Met Asn Leu Asn Ser Gly Pro 
            100                 105                 110         


Ile Asp Gln Val Arg Leu Thr Gly Val Phe Gly Cys Thr Thr Val Arg 
        115                 120                 125             


Thr Thr Ser Ser Ser Gly Ser Pro Ile Ser Thr Val Tyr Tyr Val Gln 
    130                 135                 140                 


Asn Asp Gly Phe Leu Tyr Trp Val Met Asn Ser Val Val Tyr Val Thr 
145                 150                 155                 160 


Leu Val Lys Asn Gly Ile Ser Leu Phe Asp Val Thr Val Tyr Lys Gly 
                165                 170                 175     


Asn Leu Tyr Leu Leu Ser Ala Gln Asn Arg Ile Tyr Lys Cys Leu Ile 
            180                 185                 190         


Gly Pro Gly Gly Ala Val Thr Gly Ser Ala Cys Thr Gln Val Met Leu 
        195                 200                 205             


Ala Gly Ser Thr Ala Tyr Ala Asn Leu Ser Glu Thr Ser Thr Ser Glu 
    210                 215                 220                 


Phe Lys Gly Phe Ala Val Ser Ser Ala Gly Ile Phe Ile Ala Pro Ser 
225                 230                 235                 240 


Ser Ser Leu Tyr Trp Phe Asn Leu Ala Gly Gly Tyr Ile Ala Ser Thr 
                245                 250                 255     


Thr Thr Ala Val Val Phe Val Asp Val Lys Phe Thr Ser Asn Arg Asp 
            260                 265                 270         


Thr Ala Asn Pro Gly Ile Pro Thr Leu Met Ala Ala Ser Thr Ser Ala 
        275                 280                 285             


Val Tyr Arg Val Ser Thr Ala Gly Thr Ser Ile Thr Tyr Thr Leu Ile 
    290                 295                 300                 


Ala Gly Lys Glu Thr Ala Thr Cys Asn Leu Ala Leu Asp Asn Val Asp 
305                 310                 315                 320 


Ser Leu Thr Asp Pro Ser Phe Cys Gly Ile Ala Arg Ile Tyr Pro Leu 
                325                 330                 335     


Ser Leu Asp Val Val Tyr Met Thr Thr Ala Gly Ala Ser Val Val Arg 
            340                 345                 350         


Ala Ile Val Val Ser Asn Thr Thr Ile Arg Asp Thr Ile Thr Arg Thr 
        355                 360                 365             


Pro Phe Pro Leu Tyr Phe Leu Asp Arg Ala Ser Thr Ile Pro Val Leu 
    370                 375                 380                 


Leu Asp Gly Met Asn Tyr Glu Ile Val Gly His Ser Asn Val Pro Phe 
385                 390                 395                 400 


Pro Tyr Val Ala Ile Asp Gln Ser Thr Pro Glu Val Asn Asp Thr Thr 
                405                 410                 415     


Trp Asp Thr Ser Phe Gly Val Asp Ile Ser Asn Arg Phe Phe Ser Met 
            420                 425                 430         


Ala Ser Ser Ala Ala Val Thr Ser Thr Pro Phe Met Gly Ser Leu His 
        435                 440                 445             


Gly Leu Glu Thr Tyr Tyr Asn Arg Thr Asn Gln Ile Ile Phe Gly Asp 
    450                 455                 460                 


Pro Asn Val Leu Pro Met Cys Asn Leu Thr Lys Met Leu Met Ile Glu 
465                 470                 475                 480 


Arg Ala Val Ala Thr Ala Ala Arg Ala Ala Leu Lys Tyr Pro Tyr Ile 
                485                 490                 495     


Tyr Thr Ser Asn Ala Gln Asn Phe Thr Val Asn Ala Gln Pro Asn Leu 
            500                 505                 510         


Thr Leu Val Lys Leu Leu Met Pro Tyr Ala Phe Gly Glu Ile Leu Asn 
        515                 520                 525             


Glu Leu Gly Phe Phe Glu Asn Thr Thr Thr Ala Ala Ala Leu Ala Ala 
    530                 535                 540                 


Val Gln Phe Asn Thr Thr Met Leu Ala Ala Val Arg Ser Ala Tyr Met 
545                 550                 555                 560 


Met Asp Arg Val Tyr Asp Cys Ile Phe Ser Gly Asn Ala Tyr Pro Phe 
                565                 570                 575     


His Val Leu Thr Ala Ala Gln Gln Gln Glu Val Arg Trp Ile Ile Tyr 
            580                 585                 590         


Ser Ala Ile Gln Asn Gln Leu Ala Arg Cys Asn Gln Ser Ile Pro Tyr 
        595                 600                 605             


Leu Gly Pro Asp Ser Asn Ser Ser Asn Ser Tyr Asn Asn Met Ala Pro 
    610                 615                 620                 


Gly Cys Val Pro Arg Ile Gly Ile Asn Asn Leu Thr Glu Met Leu Leu 
625                 630                 635                 640 


Pro Gly Leu Pro Tyr Ser Asn Phe Asn Ile Thr Val Phe Ile Pro Glu 
                645                 650                 655     


Ser Leu Tyr Tyr Asn Phe Gly Ile Ser Arg Cys Leu Asp Gly Thr Asp 
            660                 665                 670         


Trp Thr Asp Val Met Gly Tyr Leu Ile Asn Ala Thr Thr Arg Asn Asn 
        675                 680                 685             


Arg Lys Cys Asn Thr Gly Cys Ile Val Gly Ile Ala Val Ala Ser Ala 
    690                 695                 700                 


Leu Val Ala Ser Phe Leu Val Val Ala Ile Val Ile Met Thr Ser Lys 
705                 710                 715                 720 


Arg Arg Arg Leu Ala Thr Val Val Ala Pro Ala Ala Thr Ser Glu Pro 
                725                 730                 735     


Lys Phe Ile Ser Thr Leu Asp Met Thr Ser Glu Glu Gly Ser Arg Asn 
            740                 745                 750         


Pro Leu Thr Arg 
        755     


<210>  50
<211>  756
<212>  PRT
<213>  Leishmania donovani

<400>  50

Met Gly Arg Cys Ile Arg Arg Val Ser Ser Ala Ala Ala Ala Ala Leu 
1               5                   10                  15      


Leu Ile Ala Leu Ala Ala Ala Ala Ala Val Ala Thr Thr Thr Ala Arg 
            20                  25                  30          


Ala Tyr Asp His Ala Gly Ile Thr Val Ala Gly Ala Leu Leu Val Gly 
        35                  40                  45              


Gln Asn Leu Gln Gly Lys Ala Gly Ala Ser Arg Ile Leu Asn Pro Phe 
    50                  55                  60                  


Ala Ile Cys Ala Asp Phe Asp Thr Ala Asp Val Glu Asp Thr Thr Leu 
65                  70                  75                  80  


Leu Ile Gly Gly Ala Ser Tyr Phe Phe Ser Phe Asn Arg Tyr Ser Thr 
                85                  90                  95      


Tyr Leu Gly Phe Trp Tyr Gly Gln Gly Ser Met Asn Leu Asn Ser Gly 
            100                 105                 110         


Pro Ile Asp Lys Val Arg Leu Thr Gly Val Phe Gly Cys Val Thr Leu 
        115                 120                 125             


Arg Pro Asn Ser Ser Asn Gly Leu Val Thr Ser Thr Val Tyr Tyr Val 
    130                 135                 140                 


Gln Asn Asp Gly Met Leu Tyr Trp Val Ser Asn Ser Val Val Tyr Leu 
145                 150                 155                 160 


Thr Gln Val Lys His Gly Ile Ser Phe Val Asp Val Thr Val His Asp 
                165                 170                 175     


Asn Asn Val Tyr Leu Leu Ser Thr Gln Asn Gly Ile Tyr Gln Cys Gly 
            180                 185                 190         


Ile Gly Ala Gly Gly Ala Val Val Gly Ser Ala Cys Thr Gln Ile Thr 
        195                 200                 205             


Leu Thr Gly Ser Thr Glu Phe His Gln Leu Ile Pro Ile Ser Ser Asp 
    210                 215                 220                 


Phe Arg Gly Phe Ala Val Ser Ser Ser Gly Ile Phe Ile Thr Pro Thr 
225                 230                 235                 240 


Ser Asp Leu Tyr Trp Phe Asn Leu Ser Gly Ala Phe Ile Ala Lys Ser 
                245                 250                 255     


Val Gly Val Thr Phe Val Asp Thr Lys Phe Thr Ser Ser Arg Asp Thr 
            260                 265                 270         


Ala Asn Arg Gly Thr Ser Val Leu Met Ala Ala Ser Thr Ser Ala Val 
        275                 280                 285             


Tyr Thr Val Thr Thr Ser Asp Ala Thr Ile Ser Tyr Ala Leu Val Ser 
    290                 295                 300                 


Gly Lys Glu Val Lys Ser Cys Asn Pro Ala Leu Asn Asn Val Asp Ser 
305                 310                 315                 320 


Asp Thr Ser Pro Thr Phe Cys Gly Ile Ala Arg Ile Tyr Pro Leu Ser 
                325                 330                 335     


Thr Asp Met Val Tyr Met Thr Thr Gly Gly Ala Ser Val Val Arg Ala 
            340                 345                 350         


Ile Ile Val Ser Asn Thr Thr Ile Ser Asp Thr Ile Thr Arg Thr Pro 
        355                 360                 365             


Phe Pro Val Tyr Phe Leu Asp Asn Ser Ser Ile Met Pro Leu Ile Leu 
    370                 375                 380                 


Asp Gly Met Asn Tyr Glu Leu Val Ser Asn Ser Asn Ile Pro Phe Pro 
385                 390                 395                 400 


Tyr Val Ala Ile Asn His Ser Thr Pro Lys Val Asp Asp Ser Thr Trp 
                405                 410                 415     


Asp Thr Ile Phe Ser Val Asp Val Ser Asn Arg Phe Phe Ser Thr Val 
            420                 425                 430         


Ser Arg Ala Ala Val Ile Gly Thr Pro Phe Met Ser Ser Leu His Gly 
        435                 440                 445             


Leu Gln Ala Tyr Tyr Asn Arg Thr Asn His Ile Leu Phe Gly Asp Pro 
    450                 455                 460                 


Asn Val Leu Pro Met Cys Asn Leu Thr Lys Met Gln Met Ile Glu Arg 
465                 470                 475                 480 


Ala Val Ala Ala Asp Ala Arg Ala Ala Leu Gln Tyr Pro Tyr Ile Tyr 
                485                 490                 495     


Thr Ser Lys Ala Gln Asn Phe Thr Val Asn Ala His Pro Asn Leu Thr 
            500                 505                 510         


Leu Leu Lys Leu Leu Met Pro Tyr Pro Phe Gly Glu Ile Leu Asn Glu 
        515                 520                 525             


Ser Gly Phe Phe Glu Asn Thr Thr Thr Pro Ala Ser Leu Ala Asn Val 
    530                 535                 540                 


His Phe Asn Thr Thr Met Leu Ala Ala Val Arg Asn Ala Tyr Thr Pro 
545                 550                 555                 560 


Asp Phe Val Tyr Asp Cys Ile Phe Ala Gly Asn Ala Phe Pro Phe His 
                565                 570                 575     


Ile Leu Thr Ala Ala Gln Gln Gln Leu Val Arg Trp Ile Ile Tyr Thr 
            580                 585                 590         


Ala Ile Gln Glu Gln Leu Ala Lys Cys Ala Glu Asn Ser Pro Ser Tyr 
        595                 600                 605             


Thr Gly Ser Gly Ser Ser Ser Ser Asp Ser His Asp Asp Met Val Pro 
    610                 615                 620                 


Gly Cys Val Pro Arg Val Gly Ile Asp Asn Leu Thr Glu Leu Val Met 
625                 630                 635                 640 


Pro Gly Met Pro Tyr Ser Asn Tyr Asn Ile Thr Val Phe Ile Pro Glu 
                645                 650                 655     


Ser Leu His Tyr Asn Phe Ser Ile Ser Arg Cys Leu Asp Gly Thr Asp 
            660                 665                 670         


Trp Thr Asn Val Thr Asp Tyr Leu Gln Asn Ala Thr Thr Thr Arg Thr 
        675                 680                 685             


Arg Lys Cys Gly Thr Gly Cys Ile Val Ser Ile Ala Val Val Ser Ala 
    690                 695                 700                 


Val Val Ala Ala Ile Leu Val Val Ala Ile Val Ile Ala Thr Ser Lys 
705                 710                 715                 720 


Arg Arg Arg Leu Ala Thr Val Val Ala Pro Ala Leu Thr Val Glu Pro 
                725                 730                 735     


Lys Phe Ala Ser Thr Leu Asp Met Gly Ser Glu Glu Gly Ser Arg Asn 
            740                 745                 750         


Pro Leu Asn Gly 
        755     


<210>  51
<211>  756
<212>  PRT
<213>  Leishmania donovani

<400>  51

Met Gly Arg Cys Ile Arg Arg Val Ser Ser Ala Ala Ala Ala Ala Leu 
1               5                   10                  15      


Leu Ile Ala Leu Ala Ala Ala Ala Ala Val Ala Thr Thr Thr Ala Arg 
            20                  25                  30          


Ala Tyr Asp His Ala Gly Ile Thr Val Ala Gly Ala Leu Leu Val Gly 
        35                  40                  45              


Gln Asn Leu Gln Gly Lys Ala Gly Ala Ser Arg Ile Leu Asn Pro Phe 
    50                  55                  60                  


Ala Ile Cys Ala Asp Phe Asp Thr Ala Asp Val Glu Asp Thr Thr Leu 
65                  70                  75                  80  


Leu Ile Gly Gly Ala Ser Tyr Phe Phe Ser Phe Asn Arg Tyr Ser Thr 
                85                  90                  95      


Tyr Leu Gly Phe Trp Tyr Gly Gln Gly Ser Met Asn Leu Asn Ser Gly 
            100                 105                 110         


Pro Ile Asp Lys Val Arg Leu Thr Gly Val Phe Gly Cys Val Thr Leu 
        115                 120                 125             


Arg Pro Asn Ser Ser Asn Gly Leu Val Thr Ser Thr Val Tyr Tyr Val 
    130                 135                 140                 


Gln Asn Asp Gly Met Leu Tyr Trp Val Ser Asn Ser Val Val Tyr Leu 
145                 150                 155                 160 


Thr Gln Val Lys His Gly Ile Ser Phe Val Asp Val Thr Val His Asp 
                165                 170                 175     


Asn Asn Val Tyr Leu Leu Ser Thr Gln Asn Gly Ile Tyr Gln Cys Gly 
            180                 185                 190         


Ile Gly Ala Gly Gly Ala Val Val Gly Ser Ala Cys Thr Gln Ile Thr 
        195                 200                 205             


Leu Thr Gly Ser Thr Glu Phe His Gln Leu Ile Pro Ile Ser Ser Asp 
    210                 215                 220                 


Phe Arg Gly Phe Ala Val Ser Ser Ser Gly Ile Phe Ile Thr Pro Thr 
225                 230                 235                 240 


Ser Asp Leu Tyr Trp Phe Asn Leu Ser Gly Ala Phe Ile Ala Lys Ser 
                245                 250                 255     


Val Gly Val Thr Phe Val Asp Thr Lys Phe Thr Ser Ser Arg Asp Thr 
            260                 265                 270         


Ala Asn Arg Gly Thr Ser Val Leu Met Ala Ala Ser Thr Ser Ala Val 
        275                 280                 285             


Tyr Thr Val Thr Thr Ser Asp Ala Thr Ile Ser Tyr Ala Leu Val Ser 
    290                 295                 300                 


Gly Lys Glu Val Lys Ser Cys Asn Pro Ala Leu Asn Asn Val Asp Ser 
305                 310                 315                 320 


Asp Thr Ser Pro Thr Phe Cys Gly Ile Thr Arg Ile Tyr Pro Leu Ser 
                325                 330                 335     


Thr Asp Met Val Tyr Met Thr Thr Gly Gly Ala Ser Val Val Arg Ala 
            340                 345                 350         


Ile Ile Val Ser Asn Thr Thr Ile Ser Asp Thr Ile Thr Arg Thr Pro 
        355                 360                 365             


Phe Pro Val Tyr Phe Leu Asp Asn Ser Ser Ile Met Pro Leu Ile Leu 
    370                 375                 380                 


Asp Gly Met Asn Tyr Glu Leu Val Ser Asn Ser Asn Ile Pro Phe Pro 
385                 390                 395                 400 


Tyr Val Ala Ile Asn His Ser Thr Pro Lys Val Asp Asp Ser Thr Trp 
                405                 410                 415     


Asp Thr Ile Phe Ser Val Asp Val Ser Asn Arg Phe Phe Ser Thr Val 
            420                 425                 430         


Ser Arg Ala Ala Val Ile Gly Thr Pro Phe Met Ser Ser Leu His Gly 
        435                 440                 445             


Leu Gln Ala Tyr Tyr Asn Arg Thr Asn His Ile Leu Phe Gly Asp Pro 
    450                 455                 460                 


Asn Val Leu Pro Met Cys Asn Leu Thr Lys Met Gln Met Ile Glu Arg 
465                 470                 475                 480 


Ala Val Ala Ala Asp Ala Arg Ala Ala Leu Gln Tyr Pro Tyr Ile Tyr 
                485                 490                 495     


Thr Ser Lys Ala Gln Asn Phe Thr Val Asn Ala His Pro Asn Leu Thr 
            500                 505                 510         


Leu Leu Lys Leu Leu Met Pro Tyr Pro Phe Gly Glu Ile Leu Asn Glu 
        515                 520                 525             


Ser Gly Phe Phe Glu Asn Thr Thr Thr Pro Ala Ser Leu Ala Asn Val 
    530                 535                 540                 


His Phe Asn Thr Thr Met Leu Ala Ala Val Arg Asn Ala Tyr Thr Pro 
545                 550                 555                 560 


Asp Phe Val Tyr Asp Cys Ile Phe Ala Gly Asn Ala Phe Pro Phe His 
                565                 570                 575     


Ile Leu Thr Ala Ala Gln Gln Gln Leu Val Arg Trp Ile Ile Tyr Thr 
            580                 585                 590         


Ala Ile Gln Glu Gln Leu Ala Lys Cys Ala Glu Asn Ser Pro Ser Tyr 
        595                 600                 605             


Thr Gly Ser Gly Ser Ser Ser Ser Asp Ser His Asp Asp Met Val Pro 
    610                 615                 620                 


Gly Cys Val Pro Arg Val Gly Ile Asp Asn Leu Thr Glu Leu Val Met 
625                 630                 635                 640 


Pro Gly Met Pro Tyr Ser Asn Tyr Asn Ile Thr Val Phe Ile Pro Glu 
                645                 650                 655     


Ser Val His Tyr Asn Phe Ser Ile Ser Arg Cys Leu Asp Gly Thr Asp 
            660                 665                 670         


Trp Thr Asn Val Thr Asp Tyr Leu Gln Asn Ala Thr Thr Thr Arg Thr 
        675                 680                 685             


Arg Lys Cys Gly Thr Gly Cys Ile Val Ser Ile Ala Val Val Ser Ala 
    690                 695                 700                 


Val Val Ala Ala Ile Leu Val Val Ala Ile Val Ile Ala Thr Ser Lys 
705                 710                 715                 720 


Arg Arg Arg Leu Ala Thr Val Val Ala Pro Ala Leu Thr Val Glu Pro 
                725                 730                 735     


Lys Phe Ala Ser Thr Leu Asp Met Gly Ser Glu Glu Gly Ser Arg Asn 
            740                 745                 750         


Pro Leu Asn Gly 
        755     


<210>  52
<211>  756
<212>  PRT
<213>  Leishmania donovani

<400>  52

Met Gly Arg Cys Ile Arg Arg Val Ser Ser Ala Ala Ala Ala Ala Leu 
1               5                   10                  15      


Leu Ile Ala Leu Ala Ala Ala Ala Ala Val Ala Thr Thr Thr Ala Arg 
            20                  25                  30          


Ala Tyr Asp His Ala Gly Ile Thr Val Ala Gly Ala Leu Leu Val Gly 
        35                  40                  45              


Gln Asn Leu Gln Gly Lys Ala Gly Ala Ser Arg Ile Leu Asn Pro Phe 
    50                  55                  60                  


Ala Ile Cys Ala Asp Phe Asp Thr Ala Asp Val Glu Asp Thr Thr Leu 
65                  70                  75                  80  


Leu Ile Gly Gly Ala Ser Tyr Phe Phe Ser Phe Asn Arg Tyr Ser Thr 
                85                  90                  95      


Tyr Leu Gly Phe Trp Tyr Gly Gln Gly Ser Met Asn Leu Asn Ser Gly 
            100                 105                 110         


Pro Ile Asp Lys Val Arg Leu Thr Gly Val Phe Gly Cys Val Thr Leu 
        115                 120                 125             


Arg Pro Asn Ser Ser Asn Gly Leu Val Thr Ser Thr Val Tyr Tyr Val 
    130                 135                 140                 


Gln Asn Asp Gly Met Leu Tyr Trp Val Ser Asn Ser Val Val Tyr Leu 
145                 150                 155                 160 


Thr Gln Val Lys His Gly Ile Ser Phe Val Asp Val Thr Val His Asp 
                165                 170                 175     


Asn Asn Val Tyr Leu Leu Ser Thr Gln Asn Gly Ile Tyr Gln Cys Gly 
            180                 185                 190         


Ile Gly Ala Gly Gly Ala Val Val Gly Ser Ala Cys Thr Gln Ile Thr 
        195                 200                 205             


Leu Thr Gly Ser Thr Glu Phe His Gln Leu Ile Pro Ile Ser Ser Asp 
    210                 215                 220                 


Phe Arg Gly Phe Ala Val Ser Ser Ser Gly Ile Phe Ile Thr Pro Thr 
225                 230                 235                 240 


Ser Asp Leu Tyr Trp Phe Asn Leu Ser Gly Ala Phe Ile Ala Lys Ser 
                245                 250                 255     


Val Gly Val Thr Phe Val Asp Thr Lys Phe Thr Ser Ser Arg Asp Thr 
            260                 265                 270         


Ala Asn Arg Gly Thr Ser Val Leu Met Ala Ala Ser Thr Ser Ala Val 
        275                 280                 285             


Tyr Thr Val Thr Thr Ser Asp Ala Thr Ile Ser Tyr Ala Leu Val Ser 
    290                 295                 300                 


Gly Lys Glu Val Lys Ser Cys Asn Pro Ala Leu Asn Asn Val Asp Ser 
305                 310                 315                 320 


Asp Thr Ser Pro Thr Phe Cys Gly Ile Ala Arg Ile Tyr Pro Leu Ser 
                325                 330                 335     


Thr Asp Met Val Tyr Met Thr Thr Gly Gly Ala Ser Val Val Arg Ala 
            340                 345                 350         


Ile Ile Val Ser Asn Thr Thr Val Ser Asp Thr Ile Thr Arg Thr Pro 
        355                 360                 365             


Phe Pro Val Tyr Phe Leu Asp Asn Ser Ser Ile Met Pro Leu Ile Leu 
    370                 375                 380                 


Asp Gly Met Asp Tyr Glu Leu Val Ser Asn Ser Asn Ile Pro Phe Pro 
385                 390                 395                 400 


Tyr Val Ala Ile Asn His Ser Thr Pro Lys Val Asp Asp Ser Thr Trp 
                405                 410                 415     


Asp Thr Ile Phe Ser Val Asp Val Ser Asn Arg Phe Phe Ser Thr Val 
            420                 425                 430         


Ser Arg Ala Ala Val Ile Gly Thr Pro Phe Met Ser Ser Leu His Gly 
        435                 440                 445             


Leu Gln Ala Tyr Tyr Asn Arg Thr Asn His Ile Leu Phe Gly Asp Pro 
    450                 455                 460                 


Asn Val Leu Pro Met Cys Asn Leu Thr Lys Met Gln Met Ile Glu Arg 
465                 470                 475                 480 


Ala Val Ala Ala Asp Ala Arg Ala Ala Leu Gln Tyr Pro Tyr Ile Tyr 
                485                 490                 495     


Thr Ser Lys Ala Gln Asn Phe Thr Val Asn Ala His Pro Asn Leu Thr 
            500                 505                 510         


Leu Leu Lys Leu Leu Met Pro Tyr Pro Phe Gly Glu Ile Leu Asn Glu 
        515                 520                 525             


Ser Gly Phe Phe Glu Asn Thr Thr Thr Pro Ala Ser Leu Ala Asn Val 
    530                 535                 540                 


His Phe Asn Thr Thr Met Leu Ala Ala Val Arg Asn Ala Tyr Thr Pro 
545                 550                 555                 560 


Asp Phe Val Tyr Asp Cys Ile Phe Ala Gly Asn Ala Phe Pro Phe His 
                565                 570                 575     


Ile Leu Thr Ala Ala Gln Gln Gln Leu Val Arg Trp Ile Ile Tyr Thr 
            580                 585                 590         


Ala Ile Gln Glu Gln Leu Ala Lys Cys Ala Glu Asn Ser Pro Ser Tyr 
        595                 600                 605             


Thr Gly Ser Gly Ser Ser Ser Ser Asp Ser His Asp Asp Met Val Pro 
    610                 615                 620                 


Gly Cys Val Pro Arg Val Gly Ile Asp Asn Leu Thr Glu Leu Val Met 
625                 630                 635                 640 


Pro Gly Met Pro Tyr Ser Asn Tyr Asn Ile Thr Val Phe Ile Pro Glu 
                645                 650                 655     


Ser Leu His Tyr Asn Phe Ser Ile Ser Arg Cys Leu Asp Gly Thr Asp 
            660                 665                 670         


Trp Thr Asn Val Thr Asp Tyr Leu Gln Asn Ala Thr Thr Thr Arg Thr 
        675                 680                 685             


Arg Lys Cys Gly Thr Gly Cys Ile Val Ser Ile Ala Val Val Ser Ala 
    690                 695                 700                 


Val Val Ala Ala Ile Leu Val Val Ala Ile Val Ile Ala Thr Ser Lys 
705                 710                 715                 720 


Arg Arg Arg Leu Ala Thr Val Val Ala Pro Ala Leu Thr Val Glu Pro 
                725                 730                 735     


Lys Phe Ala Ser Thr Leu Asp Met Gly Ser Glu Glu Gly Ser Arg Asn 
            740                 745                 750         


Pro Leu Asn Gly 
        755     


<210>  53
<211>  756
<212>  PRT
<213>  Leishmania infantum

<400>  53

Met Gly Arg Cys Ile Arg Arg Val Ser Ser Ala Ala Ala Ala Ala Leu 
1               5                   10                  15      


Leu Ile Ala Leu Ala Ala Ala Ala Ala Val Ala Thr Thr Thr Ala Arg 
            20                  25                  30          


Ala Tyr Asp His Ala Gly Ile Thr Val Ala Gly Ala Leu Leu Val Gly 
        35                  40                  45              


Gln Asn Leu Gln Gly Lys Ala Gly Ala Ser Arg Ile Leu Asn Pro Phe 
    50                  55                  60                  


Ala Ile Cys Ala Asp Phe Asp Thr Ala Asp Val Glu Asp Thr Thr Leu 
65                  70                  75                  80  


Leu Ile Gly Gly Ala Ser Tyr Phe Phe Ser Phe Asn Arg Tyr Ser Thr 
                85                  90                  95      


Tyr Leu Gly Phe Trp Tyr Gly Gln Gly Ser Met Asn Leu Asn Ser Gly 
            100                 105                 110         


Pro Ile Asp Lys Val Arg Leu Thr Gly Val Phe Gly Cys Val Thr Leu 
        115                 120                 125             


Arg Pro Asn Ser Ser Asn Gly Leu Val Thr Ser Thr Val Tyr Tyr Val 
    130                 135                 140                 


Gln Asn Asp Gly Met Leu Tyr Trp Val Ser Asn Ser Val Val Tyr Leu 
145                 150                 155                 160 


Thr Gln Val Lys His Gly Ile Ser Phe Val Asp Val Thr Val His Asp 
                165                 170                 175     


Asn Asn Val Tyr Leu Leu Ser Thr Gln Asn Gly Ile Tyr Gln Cys Gly 
            180                 185                 190         


Ile Gly Ala Gly Gly Ala Val Val Gly Ser Ala Cys Thr Gln Ile Thr 
        195                 200                 205             


Leu Thr Gly Ser Thr Glu Phe His Gln Leu Ile Pro Ile Ser Ser Asp 
    210                 215                 220                 


Phe Arg Gly Phe Ala Val Ser Ser Ser Gly Ile Phe Ile Thr Pro Thr 
225                 230                 235                 240 


Ser Asp Leu Tyr Trp Phe Asn Leu Ser Gly Ala Phe Ile Ala Lys Ser 
                245                 250                 255     


Val Gly Val Thr Phe Val Asp Thr Lys Phe Thr Ser Ser Arg Asp Thr 
            260                 265                 270         


Ala Asn Arg Gly Thr Ser Val Leu Met Ala Ala Ser Thr Ser Ala Val 
        275                 280                 285             


Tyr Thr Val Thr Thr Ser Asp Ala Thr Ile Ser Tyr Ala Leu Val Ser 
    290                 295                 300                 


Gly Lys Glu Val Lys Ser Cys Asn Pro Ala Leu Asn Asn Val Asp Ser 
305                 310                 315                 320 


Asp Thr Ser Pro Thr Phe Cys Gly Ile Ala Arg Ile Tyr Pro Leu Ser 
                325                 330                 335     


Thr Asp Met Val Tyr Met Thr Thr Gly Gly Ala Ser Val Val Arg Ala 
            340                 345                 350         


Ile Ile Val Ser Asn Thr Thr Val Ser Asp Thr Ile Thr Arg Thr Pro 
        355                 360                 365             


Phe Pro Val Tyr Phe Leu Asp Asn Ser Ser Ile Met Pro Leu Ile Leu 
    370                 375                 380                 


Asp Gly Met Asn Tyr Glu Leu Val Ser Asn Ser Asn Ile Pro Phe Pro 
385                 390                 395                 400 


Tyr Val Ala Ile Asn His Ser Thr Pro Lys Val Asp Asp Ser Thr Trp 
                405                 410                 415     


Asp Thr Ile Phe Ser Val Asp Val Ser Asn Arg Phe Phe Ser Thr Val 
            420                 425                 430         


Ser Arg Ala Ala Val Ile Gly Thr Pro Phe Met Ser Ser Leu His Gly 
        435                 440                 445             


Leu Gln Ala Tyr Tyr Asn Arg Thr Asn His Ile Leu Phe Gly Asp Pro 
    450                 455                 460                 


Asn Val Leu Pro Met Cys Asn Leu Thr Lys Met Gln Met Ile Glu Arg 
465                 470                 475                 480 


Ala Val Ala Ala Asp Ala Arg Ala Ala Leu Gln Tyr Pro Tyr Ile Tyr 
                485                 490                 495     


Thr Ser Lys Ala Gln Asn Phe Thr Val Asn Ala His Pro Asn Leu Thr 
            500                 505                 510         


Leu Leu Lys Leu Leu Met Pro Tyr Pro Phe Gly Glu Ile Leu Asn Glu 
        515                 520                 525             


Ser Gly Phe Phe Glu Asn Thr Thr Thr Pro Ala Ser Leu Ala Asn Val 
    530                 535                 540                 


His Phe Asn Thr Thr Met Leu Ala Ala Val Arg Asn Ala Tyr Thr Pro 
545                 550                 555                 560 


Asp Phe Val Tyr Asp Cys Ile Phe Ala Gly Asn Ala Phe Pro Phe His 
                565                 570                 575     


Ile Leu Thr Ala Ala Gln Gln Gln Leu Val Arg Trp Ile Ile Tyr Thr 
            580                 585                 590         


Ala Ile Gln Glu Gln Leu Ala Lys Cys Ala Glu Asn Ser Pro Ser Tyr 
        595                 600                 605             


Thr Gly Ser Gly Ser Ser Ser Ser Asp Ser His Asp Asp Met Val Pro 
    610                 615                 620                 


Gly Cys Val Pro Arg Val Gly Ile Asp Asn Leu Thr Glu Leu Val Met 
625                 630                 635                 640 


Pro Gly Met Pro Tyr Ser Asn Tyr Asn Ile Thr Val Phe Ile Pro Glu 
                645                 650                 655     


Ser Leu His Tyr Asn Phe Ser Ile Ser Arg Cys Leu Asp Gly Thr Asp 
            660                 665                 670         


Trp Thr Asn Val Thr Asp Tyr Leu Gln Asn Ala Thr Thr Thr Arg Thr 
        675                 680                 685             


Arg Lys Cys Gly Thr Gly Cys Ile Val Ser Ile Ala Val Val Ser Ala 
    690                 695                 700                 


Val Val Ala Ala Ile Leu Val Val Ala Ile Val Ile Ala Thr Ser Lys 
705                 710                 715                 720 


Arg Arg Arg Leu Ala Thr Val Val Ala Pro Ala Leu Thr Val Glu Pro 
                725                 730                 735     


Lys Phe Ala Ser Thr Leu Asp Met Gly Ser Glu Glu Gly Ser Arg Asn 
            740                 745                 750         


Pro Leu Asn Gly 
        755     


<210>  54
<211>  757
<212>  PRT
<213>  Leishmania major

<400>  54

Met Gly Arg Cys Ile Arg Arg Val Ser Ala Leu Lys Ala Ala Ala Ala 
1               5                   10                  15      


Leu Leu Leu Ala Leu Val Ala Ala Ala Ala Val Ala Thr Thr Thr Ala 
            20                  25                  30          


Arg Ala Tyr Asp His Ala Gly Ile Thr Val Ala Gly Ala Ile Leu Val 
        35                  40                  45              


Gly Gln Asn Leu Gln Gly Lys Ala Gly Ala Ser Arg Ile Leu Asn Pro 
    50                  55                  60                  


Phe Ala Ile Cys Ala Asn Phe Asp Thr Thr Asp Ala Glu Asp Thr Thr 
65                  70                  75                  80  


Leu Leu Ile Gly Gly Ala Ser Tyr Phe Phe Thr Leu Asn Arg Tyr Ser 
                85                  90                  95      


Thr Tyr Leu Gly Phe Trp Tyr Gly Gln Gly Ser Met Asn Leu Asn Asn 
            100                 105                 110         


Gly Pro Ile Asp Lys Val Arg Leu Thr Gly Val Phe Gly Cys Val Thr 
        115                 120                 125             


Leu Arg Pro Asn Ser Ser Asn Gly Leu Val Thr Ser Thr Val Tyr Tyr 
    130                 135                 140                 


Val Gln Asn Asp Gly Met Leu Tyr Trp Val Ser Asn Ser Val Val Tyr 
145                 150                 155                 160 


Leu Thr Gln Val Lys Tyr Gly Ile Ser Phe Val Asp Val Thr Val His 
                165                 170                 175     


Asp Asn Asn Val Tyr Leu Leu Ser Asn Gln Asn Glu Ile Tyr Trp Cys 
            180                 185                 190         


Gly Ile Gly Ala Gly Gly Thr Val Val Gly Ser Ala Cys Thr His Ile 
        195                 200                 205             


Thr Leu Thr Gly Ser Thr Glu Phe His Gln Leu Ile Thr Val Ser Ser 
    210                 215                 220                 


Asp Phe Arg Gly Phe Ala Val Ser Ser Ser Gly Ile Phe Ile Ala Pro 
225                 230                 235                 240 


Thr Ser Asp Leu Tyr Trp Phe Asn Leu Ser Gly Val Phe Ile Ala Lys 
                245                 250                 255     


Ser Ala Gly Val Thr Phe Val Asp Thr Lys Phe Thr Ser Ser Arg Asp 
            260                 265                 270         


Thr Val Asn Arg Glu Thr Pro Val Leu Met Ala Ala Ser Thr Ser Ala 
        275                 280                 285             


Val Tyr Ser Val Thr Thr Ser Gly Ala Thr Ile Ser Tyr Thr Leu Val 
    290                 295                 300                 


Ser Gly Lys Glu Thr Lys Ser Cys Asn Pro Ala Leu Ser Asn Val Asp 
305                 310                 315                 320 


Ser Asp Thr Ser Pro Thr Phe Cys Gly Ile Ala Arg Ile Tyr Pro Leu 
                325                 330                 335     


Asn Thr Asp Thr Val Tyr Met Thr Thr Gly Gly Ala Ser Val Val Arg 
            340                 345                 350         


Ala Ile Ile Val Ser Asn Thr Thr Ile Ser Asp Thr Ile Thr Arg Thr 
        355                 360                 365             


Pro Phe Pro Val Tyr Phe Leu Asp Asn Ser Ser Ile Ile Pro Leu Ile 
    370                 375                 380                 


Leu Asp Gly Met Asn Tyr Glu Leu Val Gly Asn Ser Asn Ile Pro Phe 
385                 390                 395                 400 


Pro Tyr Val Ala Ile Asn His Ser Thr Pro Glu Val Asp Asp Ser Thr 
                405                 410                 415     


Trp Asp Thr Thr Phe Ser Val Asp Val Ser Asn Arg Phe Phe Ser Ser 
            420                 425                 430         


Val Ser Ser Ala Ala Val Val Ser Thr Pro Phe Met Gly Ser Leu His 
        435                 440                 445             


Gly Leu Gln Ala Tyr Tyr Asn Arg Thr Asn Gln Ile Leu Phe Gly Asp 
    450                 455                 460                 


Pro Asn Val Leu Pro Met Cys Asn Leu Thr Lys Met Leu Met Ile Glu 
465                 470                 475                 480 


Arg Ala Val Ala Ala Asp Ala Arg Ala Ala Leu Gln Tyr Pro Tyr Ile 
                485                 490                 495     


Tyr Thr Ser Lys Ala Gln Asn Phe Thr Val Asn Ala His Pro Asn Leu 
            500                 505                 510         


Thr Leu Leu Lys Leu Leu Met Pro Tyr Pro Phe Gly Glu Ile Leu Asn 
        515                 520                 525             


Glu Ser Gly Phe Phe Glu Asn Thr Thr Thr Pro Ala Ala Leu Ala Asn 
    530                 535                 540                 


Val His Phe Asn Thr Thr Met Leu Ala Ala Val Arg Asn Ala Tyr Thr 
545                 550                 555                 560 


Pro Asp Phe Val Tyr Asp Cys Ile Phe Ala Gly Asn Ala Phe Pro Phe 
                565                 570                 575     


Tyr Ile Leu Thr Ala Ala Gln Gln Gln Leu Val Arg Trp Ile Ile Tyr 
            580                 585                 590         


Thr Ala Ile Gln Glu Gln Leu Ala Lys Cys Ala Glu Asn Asn Pro Ser 
        595                 600                 605             


Tyr Thr Gly Ser Asp Ser Ser Ser Ser Asp Ser His Asp Asp Met Val 
    610                 615                 620                 


Pro Gly Cys Val Pro Arg Val Gly Ile Ser Asn Leu Thr Glu Leu Val 
625                 630                 635                 640 


Met Pro Gly Met Pro Tyr Ser Asn Tyr Asn Ile Ala Val Phe Ile Pro 
                645                 650                 655     


Glu Ser Leu His Tyr Asn Phe Ser Ile Ser Arg Cys Leu Asp Gly Thr 
            660                 665                 670         


Asp Trp Thr Asn Val Thr Glu Tyr Leu Gln Gln Ala Thr Val Ala Arg 
        675                 680                 685             


Thr Arg Lys Cys Gly Thr Gly Cys Ile Val Ser Ile Ala Val Val Ser 
    690                 695                 700                 


Ala Val Val Ala Ala Ile Leu Val Val Ala Ile Val Ile Ala Thr Ser 
705                 710                 715                 720 


Lys Arg Arg Arg Leu Ala Thr Val Val Ala Pro Ala Leu Thr Val Glu 
                725                 730                 735     


Pro Lys Phe Ala Ser Thr Leu Asp Val Ser Ser Glu Glu Gly Ser Arg 
            740                 745                 750         


Asn Pro Leu Asn Gly 
        755         


<210>  55
<211>  757
<212>  PRT
<213>  Leishmania major

<400>  55

Met Gly Arg Cys Ile Arg Arg Val Ser Ala Leu Lys Ala Ala Ala Ala 
1               5                   10                  15      


Leu Leu Leu Ala Leu Val Ala Ala Ala Ala Val Ala Thr Thr Thr Ala 
            20                  25                  30          


Arg Ala Tyr Asp His Ala Gly Ile Thr Val Ala Gly Ala Ile Leu Val 
        35                  40                  45              


Gly Gln Asn Leu Gln Gly Lys Ala Gly Ala Ser Arg Ile Leu Asn Pro 
    50                  55                  60                  


Phe Ala Ile Cys Ala Asn Phe Asp Thr Thr Asp Ala Glu Asp Thr Thr 
65                  70                  75                  80  


Leu Leu Ile Gly Gly Ala Ser Tyr Phe Phe Thr Leu Asn Arg Tyr Ser 
                85                  90                  95      


Thr Tyr Leu Gly Phe Trp Tyr Gly Gln Gly Ser Met Asn Leu Asn Asn 
            100                 105                 110         


Gly Pro Ile Asp Lys Val Arg Leu Thr Gly Val Phe Gly Cys Val Thr 
        115                 120                 125             


Leu Arg Pro Asn Ser Ser Asn Gly Leu Val Thr Ser Thr Val Tyr Tyr 
    130                 135                 140                 


Val Gln Asn Asp Gly Met Leu Tyr Trp Val Ser Asn Ser Val Val Tyr 
145                 150                 155                 160 


Leu Thr Gln Val Lys Tyr Gly Ile Ser Phe Val Asp Val Thr Val His 
                165                 170                 175     


Asp Asn Asn Val Tyr Leu Leu Ser Asn Gln Asn Glu Ile Tyr Trp Cys 
            180                 185                 190         


Gly Ile Gly Ala Gly Gly Thr Val Val Gly Ser Ala Cys Thr His Ile 
        195                 200                 205             


Thr Leu Thr Gly Ser Thr Glu Phe His Gln Leu Ile Thr Val Ser Ser 
    210                 215                 220                 


Asp Phe Arg Gly Phe Ala Val Ser Ser Ser Gly Ile Phe Ile Ala Pro 
225                 230                 235                 240 


Thr Ser Asp Leu Tyr Trp Phe Asn Leu Ser Gly Val Phe Ile Ala Lys 
                245                 250                 255     


Ser Ala Gly Val Thr Phe Val Asp Thr Lys Phe Thr Ser Ser Arg Asp 
            260                 265                 270         


Thr Val Asn Arg Glu Thr Pro Val Leu Met Ala Ala Ser Thr Ser Ala 
        275                 280                 285             


Val Tyr Ser Val Thr Thr Ser Gly Ala Thr Ile Ser Tyr Thr Leu Val 
    290                 295                 300                 


Ser Gly Lys Glu Thr Lys Ser Cys Asn Pro Ala Leu Ser Asn Val Asp 
305                 310                 315                 320 


Ser Asp Thr Ser Pro Thr Phe Cys Gly Ile Ala Arg Ile Tyr Pro Leu 
                325                 330                 335     


Asn Thr Asp Thr Val Tyr Met Thr Thr Gly Gly Ala Ser Val Val Arg 
            340                 345                 350         


Ala Ile Ile Val Ser Asn Thr Thr Ile Ser Asp Thr Ile Thr Arg Thr 
        355                 360                 365             


Pro Phe Pro Val Tyr Phe Leu Asp Asn Ser Ser Ile Ile Pro Leu Ile 
    370                 375                 380                 


Leu Asp Gly Met Asn Tyr Glu Leu Val Gly Asn Ser Asn Ile Pro Phe 
385                 390                 395                 400 


Pro Tyr Val Ala Ile Asn His Ser Thr Pro Glu Val Asp Asp Ser Thr 
                405                 410                 415     


Trp Asp Thr Thr Phe Ser Val Asp Val Ser Asn Arg Phe Phe Ser Ser 
            420                 425                 430         


Val Ser Ser Ala Ala Val Val Ser Thr Pro Phe Met Gly Ser Leu His 
        435                 440                 445             


Gly Leu Gln Ala Tyr Tyr Asn Arg Thr Asn Gln Ile Leu Phe Gly Asp 
    450                 455                 460                 


Pro Asn Val Leu Pro Met Cys Asn Leu Thr Lys Met Leu Met Ile Glu 
465                 470                 475                 480 


Arg Ala Val Ala Ala Asp Ala Arg Ala Ala Leu Gln Tyr Pro Tyr Ile 
                485                 490                 495     


Tyr Thr Ser Lys Ala Gln Asn Phe Thr Val Asn Ala His Pro Asn Leu 
            500                 505                 510         


Thr Leu Leu Lys Leu Leu Met Pro Tyr Pro Phe Gly Glu Ile Leu Asn 
        515                 520                 525             


Glu Ser Gly Phe Phe Glu Asn Thr Thr Thr Pro Ala Ala Leu Ala Asn 
    530                 535                 540                 


Val His Phe Asn Thr Thr Met Leu Ala Ala Val Arg Asn Ala Tyr Thr 
545                 550                 555                 560 


Pro Asp Phe Val Tyr Asp Cys Ile Phe Ala Gly Asn Ala Phe Pro Phe 
                565                 570                 575     


Tyr Ile Leu Thr Ala Ala Gln Gln Gln Leu Val Arg Trp Ile Ile Tyr 
            580                 585                 590         


Thr Ala Ile Gln Glu Gln Leu Ala Lys Cys Ala Glu Asn Asn Pro Ser 
        595                 600                 605             


Tyr Thr Gly Ser Asp Ser Ser Ser Ser Asp Ser His Asp Asp Met Val 
    610                 615                 620                 


Pro Gly Cys Val Pro Arg Val Gly Ile Ser Asn Leu Thr Glu Leu Val 
625                 630                 635                 640 


Met Pro Gly Met Pro Tyr Ser Asn Tyr Asn Ile Ala Val Phe Ile Pro 
                645                 650                 655     


Glu Ser Leu His Tyr Asn Phe Ser Ile Ser Arg Cys Leu Asp Gly Thr 
            660                 665                 670         


Asp Trp Thr Asn Val Thr Glu Tyr Leu Gln Gln Ala Thr Val Ala Arg 
        675                 680                 685             


Thr Arg Lys Cys Gly Thr Gly Cys Ile Val Ser Ile Ala Val Val Ser 
    690                 695                 700                 


Ala Val Val Ala Ala Ile Leu Val Val Ala Ile Val Ile Ala Thr Ser 
705                 710                 715                 720 


Lys Arg Arg Arg Leu Ala Thr Val Val Ala Pro Ala Leu Thr Val Glu 
                725                 730                 735     


Pro Lys Phe Ala Ser Thr Leu Asp Val Ser Ser Glu Glu Gly Ser Arg 
            740                 745                 750         


Asn Pro Leu Asn Gly 
        755         


<210>  56
<211>  757
<212>  PRT
<213>  Leishmania major

<400>  56

Met Gly Arg Cys Ile Arg Arg Val Ser Ala Leu Lys Ala Ala Ala Ala 
1               5                   10                  15      


Leu Leu Leu Ala Leu Val Ala Ala Ala Ala Val Ala Thr Thr Thr Ala 
            20                  25                  30          


Arg Ala Tyr Asp His Ala Gly Ile Thr Val Ala Gly Ala Ile Leu Val 
        35                  40                  45              


Gly Gln Asn Leu Gln Gly Lys Ala Gly Ala Ser Arg Ile Leu Asn Pro 
    50                  55                  60                  


Phe Ala Ile Cys Ala Asn Phe Asp Thr Thr Asp Ala Glu Asp Thr Thr 
65                  70                  75                  80  


Leu Leu Ile Gly Gly Ala Ser Tyr Phe Phe Thr Leu Asn Arg Tyr Ser 
                85                  90                  95      


Thr Tyr Leu Gly Phe Trp Tyr Gly Gln Gly Ser Met Asn Leu Asn Asn 
            100                 105                 110         


Gly Pro Ile Asp Lys Val Arg Leu Thr Gly Val Phe Gly Cys Val Thr 
        115                 120                 125             


Leu Arg Pro Asn Ser Ser Asn Gly Leu Val Thr Ser Thr Val Tyr Tyr 
    130                 135                 140                 


Val Gln Asn Asp Gly Met Leu Tyr Trp Val Ser Asn Ser Val Val Tyr 
145                 150                 155                 160 


Leu Thr Gln Val Lys Tyr Gly Ile Ser Phe Val Asp Val Thr Val His 
                165                 170                 175     


Asp Asn Asn Val Tyr Leu Leu Ser Asn Gln Asn Glu Ile Tyr Trp Cys 
            180                 185                 190         


Gly Ile Gly Ala Gly Gly Thr Val Val Gly Ser Ala Cys Thr His Ile 
        195                 200                 205             


Thr Leu Thr Gly Ser Thr Glu Phe His Gln Leu Ile Thr Val Ser Ser 
    210                 215                 220                 


Asp Phe Arg Gly Phe Ala Val Ser Ser Ser Gly Ile Phe Ile Ala Pro 
225                 230                 235                 240 


Thr Ser Asp Leu Tyr Trp Phe Asn Leu Ser Gly Val Phe Ile Ala Lys 
                245                 250                 255     


Ser Ala Gly Val Thr Phe Val Asp Thr Lys Phe Thr Ser Ser Arg Asp 
            260                 265                 270         


Thr Val Asn Arg Glu Thr Pro Val Leu Met Ala Ala Ser Thr Ser Ala 
        275                 280                 285             


Val Tyr Ser Val Thr Thr Ser Gly Ala Thr Ile Ser Tyr Thr Leu Val 
    290                 295                 300                 


Ser Gly Lys Glu Thr Lys Ser Cys Asn Pro Ala Leu Ser Asn Val Asp 
305                 310                 315                 320 


Ser Asp Thr Ser Pro Thr Phe Cys Gly Ile Ala Arg Ile Tyr Pro Leu 
                325                 330                 335     


Asn Thr Asp Thr Val Tyr Met Thr Thr Gly Gly Ala Ser Val Val Arg 
            340                 345                 350         


Ala Ile Ile Val Ser Asn Thr Thr Ile Ser Asp Thr Ile Thr Arg Thr 
        355                 360                 365             


Pro Phe Pro Val Tyr Phe Leu Asp Asn Ser Ser Ile Ile Pro Leu Ile 
    370                 375                 380                 


Leu Asp Gly Met Asn Tyr Glu Leu Val Gly Asn Ser Asn Ile Pro Phe 
385                 390                 395                 400 


Pro Tyr Val Ala Ile Asn His Ser Thr Pro Glu Val Asp Asp Ser Thr 
                405                 410                 415     


Trp Asp Thr Thr Phe Ser Val Asp Val Ser Asn Arg Phe Phe Ser Ser 
            420                 425                 430         


Val Ser Ser Ala Ala Val Val Ser Thr Pro Phe Met Gly Ser Leu His 
        435                 440                 445             


Gly Leu Gln Ala Tyr Tyr Asn Arg Thr Asn Gln Ile Leu Phe Gly Asp 
    450                 455                 460                 


Pro Asn Val Leu Pro Met Cys Asn Leu Thr Lys Met Leu Met Ile Glu 
465                 470                 475                 480 


Arg Ala Val Ala Ala Asp Ala Arg Ala Ala Leu Gln Tyr Pro Tyr Ile 
                485                 490                 495     


Tyr Thr Ser Lys Ala Gln Asn Phe Thr Val Asn Ala His Pro Asn Leu 
            500                 505                 510         


Thr Leu Leu Lys Leu Leu Met Pro Tyr Pro Phe Gly Glu Ile Leu Asn 
        515                 520                 525             


Glu Ser Gly Phe Phe Glu Asn Thr Thr Thr Pro Ala Ala Leu Ala Asn 
    530                 535                 540                 


Val His Phe Asn Thr Thr Met Leu Ala Ala Val Arg Asn Ala Tyr Thr 
545                 550                 555                 560 


Pro Asp Phe Val Tyr Asp Cys Ile Phe Ala Gly Asn Ala Phe Pro Phe 
                565                 570                 575     


Tyr Ile Leu Thr Ala Ala Gln Gln Gln Leu Val Arg Trp Ile Ile Tyr 
            580                 585                 590         


Thr Ala Ile Gln Glu Gln Leu Ala Lys Cys Ala Glu Asn Asn Pro Ser 
        595                 600                 605             


Tyr Thr Gly Ser Asp Ser Ser Ser Ser Asp Ser His Asp Asp Met Val 
    610                 615                 620                 


Pro Gly Cys Val Pro Arg Val Gly Ile Ser Asn Leu Thr Glu Leu Val 
625                 630                 635                 640 


Met Pro Gly Met Pro Tyr Ser Asn Tyr Asn Ile Ala Val Phe Ile Pro 
                645                 650                 655     


Glu Ser Leu His Tyr Asn Phe Ser Ile Ser Arg Cys Leu Asp Gly Thr 
            660                 665                 670         


Asp Trp Thr Asn Val Thr Glu Tyr Leu Gln Gln Ala Thr Val Ala Arg 
        675                 680                 685             


Thr Arg Lys Cys Gly Thr Gly Cys Ile Val Ser Ile Ala Val Val Ser 
    690                 695                 700                 


Ala Val Val Ala Ala Ile Leu Val Val Ala Ile Val Ile Ala Thr Ser 
705                 710                 715                 720 


Lys Arg Arg Arg Leu Ala Thr Val Val Ala Pro Ala Leu Thr Val Glu 
                725                 730                 735     


Pro Lys Phe Ala Ser Thr Leu Asp Val Ser Ser Glu Glu Gly Ser Arg 
            740                 745                 750         


Asn Pro Leu Asn Gly 
        755         


<210>  57
<211>  755
<212>  PRT
<213>  Leishmania mexicana

<400>  57

Met Gly Arg Cys Ile Arg Arg Val Ser Ala Ala Ala Ala Ala Leu Leu 
1               5                   10                  15      


Met Ala Leu Val Ala Ala Ala Ala Val Ala Pro Thr Thr Ala Arg Ala 
            20                  25                  30          


Tyr Asp His Ala Gly Ile Thr Val Ala Gly Ala Leu Met Val Gly Gln 
        35                  40                  45              


Asn Leu Gln Gly Thr Ala Gly Thr Ser Arg Ile Leu Asn Pro Phe Ala 
    50                  55                  60                  


Ile Cys Ala Asn Phe Asp Thr Ala Asp Val Glu Asp Thr Thr Leu Leu 
65                  70                  75                  80  


Ile Gly Gly Ala Ser Tyr Phe Phe Thr Leu Asn Arg Tyr Ser Thr Tyr 
                85                  90                  95      


Leu Gly Phe Trp Tyr Gly Gln Gly Ser Met Asn Leu Asn Ser Gly Pro 
            100                 105                 110         


Ile Asp Lys Val Arg Leu Thr Gly Val Phe Gly Cys Val Thr Leu Arg 
        115                 120                 125             


Pro Asn Pro Ser Asn Ala Leu Pro Thr Ser Ile Val Tyr Tyr Val Gln 
    130                 135                 140                 


Asn Asp Gly Phe Leu Tyr Trp Val Ser Asn Ser Ile Val Tyr Leu Thr 
145                 150                 155                 160 


Gln Leu Glu Ser Gly Ile Ser Leu Phe Asp Val Thr Val Tyr Asn Asn 
                165                 170                 175     


Ser Val Tyr Leu Leu Ser Ala Gln Asn Val Ile Tyr Arg Cys Gly Ile 
            180                 185                 190         


Gly Ala Gly Gly Ala Val Val Gly Ser Ala Cys Thr Gln Ile Pro Leu 
        195                 200                 205             


Thr Gly Ser Pro Ala Phe His Gln Leu Ile Thr Val Ser Ser Asp Phe 
    210                 215                 220                 


Arg Gly Phe Ala Val Ser Ala Ser Gly Ile Val Val Ala Pro Thr Ala 
225                 230                 235                 240 


Asp Leu Phe Trp Phe Asp Leu Ser Gly Ala Phe Ile Ser Lys Ser Ala 
                245                 250                 255     


Gly Val Thr Phe Val Asp Ala Lys Phe Thr Thr Asn Arg Asp Thr Ala 
            260                 265                 270         


Asn Arg Gly Ala Pro Val Leu Met Ala Ala Ser Thr Ser Ala Val Tyr 
        275                 280                 285             


Thr Val Ala Thr Ser Gly Ala Ser Ile Thr Tyr Thr Leu Val Ser Gly 
    290                 295                 300                 


Glu Glu Thr Gly Arg Cys Asn Pro Ala Leu Asn Asn Val Asp Ser Asp 
305                 310                 315                 320 


Thr Ser Pro Thr Phe Cys Gly Ile Ala Arg Ile Tyr Pro Leu Ser Thr 
                325                 330                 335     


Asp Met Val Tyr Met Thr Thr Gly Gly Ala Ser Val Val Arg Ala Ile 
            340                 345                 350         


Leu Val Gly Asn Thr Thr Val Arg Asp Thr Ile Thr Arg Thr Pro Phe 
        355                 360                 365             


Pro Val Tyr Phe Leu Asp Asn Ser Ser Ile Met Pro Leu Met Leu Asp 
    370                 375                 380                 


Gly Met Asn Tyr Glu Leu Val Ala Asn Ser Asp Ile Pro Phe Pro Tyr 
385                 390                 395                 400 


Val Ala Ile Asn Glu Ser Thr Pro Glu Val Ala Asp Ser Thr Trp Asp 
                405                 410                 415     


Thr Ser Phe Ser Val Asp Val Ser Asn Arg Phe Phe Ser Thr Ala Ser 
            420                 425                 430         


Ser Ala Ala Val Thr Ser Thr Pro Phe Met Gly Ser Leu His Gly Leu 
        435                 440                 445             


Gln Ala Tyr Tyr Asn Arg Thr Asn Gln Ile Leu Phe Gly Asp Pro Asn 
    450                 455                 460                 


Val Leu Pro Met Cys Asn Leu Thr Lys Met His Met Ile Glu Arg Ala 
465                 470                 475                 480 


Val Ala Ala Asp Ala Arg Ala Ala Leu Gln Tyr Pro Tyr Ile Tyr Thr 
                485                 490                 495     


Ser Arg Ala Gln Asn Phe Thr Val Asn Ala Gln Pro Asn Leu Thr Leu 
            500                 505                 510         


Leu Lys Leu Leu Met Pro Tyr Pro Phe Gly Glu Ile Leu Asn Glu Ser 
        515                 520                 525             


Gly Phe Phe Glu Asn Thr Thr Thr Pro Ala Ala Leu Ala Asn Val His 
    530                 535                 540                 


Phe Asn Lys Thr Met Leu Ala Ala Val Arg Asn Ala Tyr Ala Pro Asp 
545                 550                 555                 560 


Phe Val Tyr Asp Ser Ile Phe Ala Gly Asn Ala Phe Pro Phe His Ile 
                565                 570                 575     


Leu Thr Ala Ala Gln Gln Gln Val Val Arg Trp Val Ile Tyr Met Ala 
            580                 585                 590         


Ile Gln Glu Gln Leu Ala Lys Cys Ala Glu Asn Thr Pro Ser Tyr Pro 
        595                 600                 605             


Gly Ser Asp Ser Ser Ser Ser Asp Ser Gln Asp Asp Met Val Pro Gly 
    610                 615                 620                 


Cys Val Pro Arg Val Gly Ile Ser Asn Leu Thr Glu Gln Met Ile Pro 
625                 630                 635                 640 


Gly Leu Pro Tyr Ser Asn Phe Asn Ile Thr Val Phe Ile Pro Glu Ser 
                645                 650                 655     


Leu His Tyr Thr Phe Ser Ile Ser Arg Cys Leu Asp Gly Thr Asp Trp 
            660                 665                 670         


Thr Asn Val Thr Asp Tyr Leu Gln Asn Ala Thr Ile Thr Thr Thr Arg 
        675                 680                 685             


Lys Cys Gly Thr Gly Cys Ile Val Ser Ile Ala Val Ala Ser Ala Val 
    690                 695                 700                 


Val Ala Ala Ile Leu Val Val Ala Ile Val Ile Val Thr Ser Lys Arg 
705                 710                 715                 720 


Arg Arg Leu Ala Thr Val Val Ala Pro Ala Leu Thr Val Glu Pro Lys 
                725                 730                 735     


Phe Ala Ser Thr Leu Asp Ala Thr Ser Glu Glu Gly Ser Arg Asn Pro 
            740                 745                 750         


Leu Asn Gly 
        755 


<210>  58
<211>  756
<212>  PRT
<213>  Leishmania panamensis

<400>  58

Met Gly Arg Cys Val Tyr Arg Val Ser Ser Ala Ala Ala Thr Leu Leu 
1               5                   10                  15      


Thr Val Leu Ile Ala Ala Val Thr Val Ala Ala Thr Thr Ala Arg Ala 
            20                  25                  30          


Tyr Asp His Ala Gly Val Thr Val Ala Gly Ala Leu Leu Val Gly Gln 
        35                  40                  45              


Asn Glu Glu Gly Lys Leu Gly Thr Asn Arg Ile Leu Asn Pro Phe Ala 
    50                  55                  60                  


Leu Cys Ala Asn Phe Asp Thr Thr Asp Val Thr Asp Thr Ala Leu Leu 
65                  70                  75                  80  


Ile Gly Gly Ala Ser Tyr Phe Phe Thr Phe Asp Arg His Ser Thr Tyr 
                85                  90                  95      


Leu Ser Phe Trp Tyr Gly Gln Gly Ser Met Asn Leu Asn Ser Gly Pro 
            100                 105                 110         


Ile Asp Gln Val Arg Leu Thr Gly Val Phe Gly Cys Thr Thr Val Arg 
        115                 120                 125             


Thr Thr Ser Ser Ser Gly Ser Pro Ile Ser Thr Val Tyr Tyr Val Gln 
    130                 135                 140                 


Asn Asp Gly Phe Leu Tyr Trp Val Met Asn Ser Val Val Tyr Val Thr 
145                 150                 155                 160 


Leu Val Lys Asn Gly Ile Ser Leu Phe Asp Val Thr Val Tyr Lys Gly 
                165                 170                 175     


Asn Leu Tyr Leu Leu Ser Ala Gln Asn Ser Ile Tyr Lys Cys Leu Ile 
            180                 185                 190         


Gly Pro Gly Gly Ala Val Thr Gly Ser Ala Cys Thr Gln Val Met Leu 
        195                 200                 205             


Ala Gly Ser Thr Ala Tyr Ala Asn Leu Ser Glu Thr Ser Thr Ser Glu 
    210                 215                 220                 


Phe Lys Gly Phe Ala Val Ser Ser Ala Gly Ile Phe Ile Ala Pro Ser 
225                 230                 235                 240 


Ser Ser Leu Tyr Trp Phe Asn Leu Ala Gly Gly Tyr Ile Ala Ser Thr 
                245                 250                 255     


Thr Thr Ala Val Val Phe Val Asp Val Lys Leu Thr Ser Asn Arg Asp 
            260                 265                 270         


Thr Ala Asn Pro Gly Ile Pro Thr Leu Met Ala Ala Ser Thr Ser Ala 
        275                 280                 285             


Val Tyr Arg Val Ser Thr Ala Gly Thr Ser Ile Thr Tyr Thr Leu Ile 
    290                 295                 300                 


Ala Gly Lys Glu Thr Ala Thr Cys Asn Leu Ala Leu Asp Asn Val Asp 
305                 310                 315                 320 


Ser Leu Thr Asp Pro Ser Phe Cys Gly Ile Ala Arg Ile Tyr Pro Leu 
                325                 330                 335     


Ser Leu Asp Val Val Tyr Met Thr Thr Ala Gly Ala Ser Val Val Arg 
            340                 345                 350         


Ala Ile Val Val Ser Asn Thr Thr Ile Arg Asp Thr Ile Thr Arg Thr 
        355                 360                 365             


Pro Phe Pro Leu Tyr Phe Leu Asp Arg Ala Ser Thr Ile Pro Val Leu 
    370                 375                 380                 


Leu Asp Gly Met Asn Tyr Glu Ile Val Gly His Ser Asn Val Pro Phe 
385                 390                 395                 400 


Pro Tyr Val Ala Ile Asp Gln Ser Thr Pro Glu Val Asn Asp Thr Thr 
                405                 410                 415     


Trp Asp Thr Ser Phe Gly Val Asp Ile Ser Asn Arg Phe Phe Ser Met 
            420                 425                 430         


Ala Ser Ser Ala Ala Val Thr Ser Thr Pro Phe Met Gly Ser Leu His 
        435                 440                 445             


Gly Leu Glu Thr Tyr Tyr Asn Arg Thr Asn Gln Ile Ile Phe Gly Asp 
    450                 455                 460                 


Pro Asn Val Leu Pro Met Cys Asn Leu Thr Lys Met Leu Met Ile Glu 
465                 470                 475                 480 


Arg Ala Val Ala Thr Ala Ala Arg Ala Ala Leu Lys Tyr Pro Tyr Ile 
                485                 490                 495     


Tyr Thr Ser Asn Ala Gln Asn Phe Thr Val Asn Ala Gln Pro Asn Leu 
            500                 505                 510         


Thr Leu Val Lys Leu Leu Met Pro Tyr Ala Phe Gly Glu Ile Leu Asn 
        515                 520                 525             


Glu Leu Gly Phe Phe Glu Asn Thr Thr Thr Ala Ala Ala Leu Ala Ala 
    530                 535                 540                 


Val Gln Phe Asn Thr Thr Met Leu Ala Ala Val Arg Ser Ala Tyr Met 
545                 550                 555                 560 


Met Asp Arg Val Tyr Asp Cys Ile Phe Ser Gly Asn Ala Tyr Pro Phe 
                565                 570                 575     


His Val Leu Thr Ala Ala Gln Gln Gln Glu Val Arg Trp Ile Ile Tyr 
            580                 585                 590         


Ser Ala Ile Gln Asn Gln Leu Ala Arg Cys Asn Gln Ser Ile Pro Tyr 
        595                 600                 605             


Leu Gly Pro Asp Ser Asn Ser Ser Asn Ser Tyr Asn Asn Met Ala Pro 
    610                 615                 620                 


Gly Cys Val Pro Arg Ile Gly Ile Asn Asn Leu Thr Glu Met Leu Leu 
625                 630                 635                 640 


Pro Gly Leu Pro Tyr Ser Asn Phe Asn Ile Thr Val Phe Ile Pro Glu 
                645                 650                 655     


Ser Leu Tyr Tyr Asn Phe Gly Ile Ser Arg Cys Leu Asp Gly Thr Asp 
            660                 665                 670         


Trp Thr Asp Val Met Gly Tyr Leu Ile Asn Ala Thr Thr Arg Asn Asn 
        675                 680                 685             


Arg Lys Cys Asn Thr Gly Cys Ile Val Gly Ile Ala Val Ala Ser Ala 
    690                 695                 700                 


Leu Val Ala Ser Phe Leu Val Val Ala Ile Val Ile Met Thr Ser Lys 
705                 710                 715                 720 


Arg Arg Arg Leu Ala Thr Val Val Ala Pro Ala Ala Thr Ser Glu Pro 
                725                 730                 735     


Lys Phe Ile Ser Thr Leu Asp Met Thr Ser Glu Glu Gly Ser Arg Asn 
            740                 745                 750         


Pro Leu Thr Arg 
        755     


<210>  59
<211>  756
<212>  PRT
<213>  Leishmania panamensis

<400>  59

Met Gly Arg Cys Val Tyr Arg Val Ser Ser Ala Ala Ala Thr Leu Leu 
1               5                   10                  15      


Thr Val Leu Ile Ala Ala Val Thr Val Ala Ala Thr Thr Ala Arg Ala 
            20                  25                  30          


Tyr Asp His Ala Gly Val Thr Val Ala Gly Ala Leu Leu Val Gly Gln 
        35                  40                  45              


Asn Glu Glu Gly Lys Leu Gly Thr Asn Arg Ile Leu Asn Pro Phe Ala 
    50                  55                  60                  


Leu Cys Ala Asn Phe Asp Thr Thr Asp Val Thr Asp Thr Ala Leu Leu 
65                  70                  75                  80  


Ile Gly Gly Ala Ser Tyr Phe Phe Thr Phe Asp Arg His Ser Thr Tyr 
                85                  90                  95      


Leu Ser Phe Trp Tyr Gly Gln Gly Ser Met Asn Leu Asn Ser Gly Pro 
            100                 105                 110         


Ile Asp Gln Val Arg Leu Thr Gly Val Phe Gly Cys Thr Thr Val Arg 
        115                 120                 125             


Thr Thr Ser Ser Ser Gly Ser Pro Ile Ser Thr Val Tyr Tyr Val Gln 
    130                 135                 140                 


Asn Asp Gly Phe Leu Tyr Trp Val Met Asn Ser Val Val Tyr Val Thr 
145                 150                 155                 160 


Leu Val Lys Asn Gly Ile Ser Leu Phe Asp Val Thr Val Tyr Lys Gly 
                165                 170                 175     


Asn Leu Tyr Leu Leu Ser Ala Gln Asn Ser Ile Tyr Lys Cys Leu Ile 
            180                 185                 190         


Gly Pro Gly Gly Ala Val Thr Gly Ser Ala Cys Thr Gln Val Met Leu 
        195                 200                 205             


Ala Gly Ser Thr Ala Tyr Ala Asn Leu Ser Glu Thr Ser Thr Ser Glu 
    210                 215                 220                 


Phe Lys Gly Phe Ala Val Ser Ser Ala Gly Ile Phe Ile Ala Pro Ser 
225                 230                 235                 240 


Ser Ser Leu Tyr Trp Phe Asn Leu Ala Gly Gly Tyr Ile Ala Ser Thr 
                245                 250                 255     


Thr Thr Ala Val Val Phe Val Asp Val Lys Leu Thr Ser Asn Arg Asp 
            260                 265                 270         


Thr Ala Asn Pro Gly Ile Pro Thr Leu Met Ala Ala Ser Thr Ser Ala 
        275                 280                 285             


Val Tyr Arg Val Ser Thr Ala Gly Thr Ser Ile Thr Tyr Thr Leu Ile 
    290                 295                 300                 


Ala Gly Lys Glu Thr Ala Thr Cys Asn Leu Ala Leu Asp Asn Val Asp 
305                 310                 315                 320 


Ser Leu Thr Asp Pro Ser Phe Cys Gly Ile Ala Arg Ile Tyr Pro Leu 
                325                 330                 335     


Ser Leu Asp Val Val Tyr Met Thr Thr Ala Gly Ala Ser Val Val Arg 
            340                 345                 350         


Ala Ile Val Val Ser Asn Thr Thr Ile Arg Asp Thr Ile Thr Arg Thr 
        355                 360                 365             


Pro Phe Pro Leu Tyr Phe Leu Asp Arg Ala Ser Thr Ile Pro Val Leu 
    370                 375                 380                 


Leu Asp Gly Met Asn Tyr Glu Ile Val Gly His Ser Asn Val Pro Phe 
385                 390                 395                 400 


Pro Tyr Val Ala Ile Asp Gln Ser Thr Pro Glu Val Asn Asp Thr Thr 
                405                 410                 415     


Trp Asp Thr Ser Phe Gly Val Asp Ile Ser Asn Arg Phe Phe Ser Met 
            420                 425                 430         


Ala Ser Ser Ala Ala Val Thr Ser Thr Pro Phe Met Gly Ser Leu His 
        435                 440                 445             


Gly Leu Glu Thr Tyr Tyr Asn Arg Thr Asn Gln Ile Ile Phe Gly Asp 
    450                 455                 460                 


Pro Asn Val Leu Pro Met Cys Asn Leu Thr Lys Met Leu Met Ile Glu 
465                 470                 475                 480 


Arg Ala Val Ala Thr Ala Ala Arg Ala Ala Leu Lys Tyr Pro Tyr Ile 
                485                 490                 495     


Tyr Thr Ser Asn Ala Gln Asn Phe Thr Val Asn Ala Gln Pro Asn Leu 
            500                 505                 510         


Thr Leu Val Lys Leu Leu Met Pro Tyr Ala Phe Gly Glu Ile Leu Asn 
        515                 520                 525             


Glu Leu Gly Phe Phe Glu Asn Thr Thr Thr Ala Ala Ala Leu Ala Ala 
    530                 535                 540                 


Val Gln Phe Asn Thr Thr Met Leu Ala Ala Val Arg Ser Ala Tyr Met 
545                 550                 555                 560 


Met Asp Arg Val Tyr Asp Cys Ile Phe Ser Gly Asn Ala Tyr Pro Phe 
                565                 570                 575     


His Val Leu Thr Ala Ala Gln Gln Gln Glu Val Arg Trp Ile Ile Tyr 
            580                 585                 590         


Ser Ala Ile Gln Asn Gln Leu Ala Arg Cys Asn Gln Ser Ile Pro Tyr 
        595                 600                 605             


Leu Gly Pro Asp Ser Asn Ser Ser Asn Ser Tyr Asn Asn Met Ala Pro 
    610                 615                 620                 


Gly Cys Val Pro Arg Ile Gly Ile Asn Asn Leu Thr Glu Met Leu Leu 
625                 630                 635                 640 


Pro Gly Leu Pro Tyr Ser Asn Phe Asn Ile Thr Val Phe Ile Pro Glu 
                645                 650                 655     


Ser Leu Tyr Tyr Asn Phe Gly Ile Ser Arg Cys Leu Asp Gly Thr Asp 
            660                 665                 670         


Trp Thr Asp Val Met Gly Tyr Leu Ile Asn Ala Thr Thr Arg Asn Asn 
        675                 680                 685             


Arg Lys Cys Asn Thr Gly Cys Ile Val Gly Ile Ala Val Ala Ser Ala 
    690                 695                 700                 


Leu Val Ala Ser Phe Leu Val Val Ala Ile Val Ile Met Thr Ser Lys 
705                 710                 715                 720 


Arg Arg Arg Leu Ala Thr Val Val Ala Pro Ala Ala Thr Ser Glu Pro 
                725                 730                 735     


Lys Phe Ile Ser Thr Leu Asp Met Thr Ser Glu Glu Gly Ser Arg Asn 
            740                 745                 750         


Pro Leu Thr Arg 
        755     


<210>  60
<211>  757
<212>  PRT
<213>  Leishmania tropica

<400>  60

Met Gly Arg Cys Ile Arg Arg Val Pro Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Leu Leu Leu Ala Leu Val Ala Ala Ala Ala Val Ser Thr Thr Thr Ala 
            20                  25                  30          


Arg Ala Tyr Asp His Ala Gly Ile Thr Val Ala Gly Ala Ile Met Val 
        35                  40                  45              


Gly Gln Asn Leu Gln Gly Lys Ala Gly Ala Ser Arg Ile Leu Asn Pro 
    50                  55                  60                  


Phe Ala Ile Cys Ala Asn Phe Asp Thr Ala Asp Val Glu Asp Thr Thr 
65                  70                  75                  80  


Leu Leu Ile Gly Gly Ala Ser Tyr Phe Phe Thr Leu Asn Arg Tyr Ser 
                85                  90                  95      


Thr Tyr Leu Gly Phe Trp Tyr Gly Gln Gly Ser Met Asn Leu Asn Ser 
            100                 105                 110         


Gly Pro Ile Asp Lys Val Arg Leu Thr Gly Val Phe Gly Cys Val Thr 
        115                 120                 125             


Leu Arg Pro Asn Ser Ser Asn Gly Leu Val Thr Ser Thr Val Tyr Tyr 
    130                 135                 140                 


Val Gln Asn Asp Gly Met Leu Tyr Trp Val Ser Asn Ser Val Val Tyr 
145                 150                 155                 160 


Leu Thr Gln Val Thr His Gly Ile Ser Phe Val Asp Val Thr Val His 
                165                 170                 175     


Asp Asn Asn Val Tyr Leu Leu Ser Thr Gln Asn Arg Ile Tyr Arg Cys 
            180                 185                 190         


Ser Ile Gly Thr Gly Gly Ala Val Val Gly Ser Ala Cys Thr Gln Ile 
        195                 200                 205             


Thr Leu Thr Gly Ser Thr Glu Phe Asp Gln Leu Ile Thr Val Pro Ser 
    210                 215                 220                 


Asp Phe Arg Gly Phe Ala Val Ser Ser Cys Gly Ile Phe Ile Ala Pro 
225                 230                 235                 240 


Thr Ser Asp Leu Tyr Trp Phe Ser Leu Ser Gly Val Phe Ile Thr Lys 
                245                 250                 255     


Ser Ala Gly Val Thr Phe Val Asp Ile Lys Leu Thr Ser Ser Ser Asp 
            260                 265                 270         


Thr Ala Asn Thr Gly Thr Ser Val Phe Met Ala Ala Ser Thr Ser Ala 
        275                 280                 285             


Val Tyr Ala Val Thr Ala Ser Ser Ala Thr Ile Ser Tyr Ala Leu Val 
    290                 295                 300                 


Ser Gly Lys Glu Thr Lys Ser Cys Asn Pro Ala Leu Asn Asn Val Asp 
305                 310                 315                 320 


Ser Asp Thr Ser Pro Thr Phe Cys Gly Ile Ala Arg Ile Tyr Pro Leu 
                325                 330                 335     


Asn Thr Asp Met Val Tyr Met Thr Thr Gly Val Ala Ser Val Val Arg 
            340                 345                 350         


Ala Ile Ile Val Ser Asn Thr Thr Ile Ser Asp Thr Ile Thr Arg Thr 
        355                 360                 365             


Pro Phe Pro Val Tyr Phe Leu Asp Asn Ser Ser Ile Ile Pro Leu Ile 
    370                 375                 380                 


Leu Asp Gly Met Asn Tyr Glu Leu Val Gly Asn Ser Asn Ile Pro Phe 
385                 390                 395                 400 


Pro Tyr Val Ala Ile Asn His Ser Thr Pro Glu Val Asp Asp Ser Thr 
                405                 410                 415     


Trp Asp Thr Thr Phe Ser Val Asp Val Ser Asn Arg Phe Phe Ser Thr 
            420                 425                 430         


Val Ser Ser Ala Ala Val Val Ser Thr Pro Phe Met Gly Ser Leu His 
        435                 440                 445             


Gly Leu Gln Ala Tyr Tyr Asn Arg Thr Asn Gln Ile Leu Phe Gly Asp 
    450                 455                 460                 


Pro Asn Val Leu Pro Met Cys Asn Leu Thr Lys Met Gln Arg Ile Glu 
465                 470                 475                 480 


Arg Ala Val Ala Ala Asp Ala Arg Ala Ala Leu Gln Tyr Pro Tyr Ile 
                485                 490                 495     


Tyr Thr Ser Lys Ala Gln Asn Phe Thr Val Asn Ala His Pro Asn Leu 
            500                 505                 510         


Thr Leu Leu Lys Leu Leu Met Pro Tyr Pro Phe Gly Glu Ile Leu Asn 
        515                 520                 525             


Glu Ser Gly Phe Phe Glu Asn Thr Thr Thr Pro Ala Val Leu Ala Asn 
    530                 535                 540                 


Val His Phe Asn Thr Thr Met Leu Ala Ala Val Arg Asn Ala Tyr Thr 
545                 550                 555                 560 


Pro Asp Phe Val Tyr Asp Cys Ile Phe Ala Gly Asn Ala Phe Pro Phe 
                565                 570                 575     


Gln Ile Leu Thr Ala Ala Gln Gln Gln Leu Val Arg Trp Ile Ile Tyr 
            580                 585                 590         


Thr Ala Ile Gln Glu Gln Leu Ala Lys Cys Ala Glu Asn Ser Pro Ser 
        595                 600                 605             


Tyr Thr Gly Ser Asp Ser Ser Ser Ser Asp Ser His Asp Asp Met Val 
    610                 615                 620                 


Pro Gly Cys Val Pro Arg Val Gly Ile Gly Asn Leu Thr Glu Leu Val 
625                 630                 635                 640 


Met Pro Gly Met Pro Tyr Ser Asn Tyr Asn Ile Thr Val Phe Ile Pro 
                645                 650                 655     


Glu Gly Leu His Tyr Asn Phe Ser Ile Ser Arg Cys Leu Asp Gly Thr 
            660                 665                 670         


Asp Trp Thr Asn Val Thr Asp Tyr Leu Gln His Ala Thr Thr Pro Arg 
        675                 680                 685             


Thr Arg Lys Cys Gly Thr Gly Cys Ile Val Ser Ile Ala Val Val Ser 
    690                 695                 700                 


Ala Val Val Ala Ala Ile Leu Val Val Ala Ile Val Ile Ala Thr Ser 
705                 710                 715                 720 


Lys Arg Arg Arg Leu Ala Thr Val Val Ala Pro Ala Phe Thr Val Glu 
                725                 730                 735     


Pro Lys Phe Ala Ser Thr Leu Asp Met Ser Ser Glu Glu Gly Ser Arg 
            740                 745                 750         


Asn Pro Leu Asn Arg 
        755         


<210>  61
<211>  532
<212>  PRT
<213>  Trypanosoma vivax

<400>  61

Met Arg Cys His Glu Pro Pro Thr Pro Pro Gln Leu Ser Ala Thr Cys 
1               5                   10                  15      


Cys Val Ala Glu Glu Ile Asp Thr Tyr Asn Lys His Leu Asp Ala Leu 
            20                  25                  30          


Met Gln Ile Ile Gly Asp Ala Ile Lys Asn Ile Ser Thr Asn Glu Asp 
        35                  40                  45              


Asn Ala Arg Ala Arg Ala Glu Gly Leu Lys Gly Cys Asn Leu His Tyr 
    50                  55                  60                  


Val Gln Phe Ala Val Ala His Thr Glu Gly Ser Val Val Ala Ala Arg 
65                  70                  75                  80  


Arg Glu Ala Val Lys Ala Gln Asn Thr Ile Lys Gly Ser Thr Ser Leu 
                85                  90                  95      


Leu Lys Lys Val Thr Ile Asp Ile Ser Asn Ser Phe Arg Asn Ile Ser 
            100                 105                 110         


Ser Lys Cys Asn Glu Leu Arg Glu Lys Tyr Pro Ser Leu Ile Pro Ala 
        115                 120                 125             


Asp Lys Asn Ser Pro Pro Asn Ile Thr Phe Lys Lys Ala Val Gln Leu 
    130                 135                 140                 


Tyr Val Lys Asn Phe Ser Thr Cys Asn Val Met Tyr Ala Lys Lys Leu 
145                 150                 155                 160 


Leu Arg Leu Val Ala Gln Ser Glu Lys Ile Glu Ala Glu Val Ser Arg 
                165                 170                 175     


Ala Val Glu Arg Thr Asn Ala Ser Thr Met Glu Leu Ala Lys Leu Asp 
            180                 185                 190         


Lys Val Ala Val Gln Leu Asn Lys Asp Ile Thr Ser Asn Arg Thr Trp 
        195                 200                 205             


Ala Gly Cys Lys Leu Ala Glu Tyr His Gly Gln Met Asn Phe Val Phe 
    210                 215                 220                 


Met Gly Phe Tyr Val Leu Leu Ser Asp Ile Leu Asp Glu Leu His Ser 
225                 230                 235                 240 


Leu Leu Lys Lys Ser Lys Ser Met Gln Pro Thr Arg Leu Thr Gln Glu 
                245                 250                 255     


Glu Val Arg Arg Ala Leu Ser Lys Ala Glu Gln Val Cys His Asp Val 
            260                 265                 270         


Ser Arg Phe Val Lys Ser Leu Gly Ser Thr Leu Arg Asp Phe Thr Asn 
        275                 280                 285             


Phe Val His Arg Leu Arg Lys Glu Tyr Leu His Gly Ile Leu Arg Asn 
    290                 295                 300                 


Ala Ser Gly Phe Arg Glu Ser Phe Glu Arg Cys Tyr Lys Val Ala Thr 
305                 310                 315                 320 


Asn Asn Ser Val Thr Arg Leu Glu Ser Thr Val Glu Glu Ile Thr Ala 
                325                 330                 335     


Asn Asn Glu Asn Ile Ala Ala Trp Glu Ser Met Thr Val His Gln Trp 
            340                 345                 350         


Lys Asp Val Ser Lys Lys Leu Arg Gln Ser Leu Leu Thr Val Leu Gly 
        355                 360                 365             


Gly Ser Asn Glu Tyr Ile Leu Leu Tyr Gly Tyr Phe Gln Glu Phe Asp 
    370                 375                 380                 


Ser Met Ser Val Arg Glu Phe Ser Asn Thr Val Arg Ala Phe Arg Gln 
385                 390                 395                 400 


Ser Ile Thr Glu Met Ser Val Ala Arg Asn Val Val Gly Val Ala Ala 
                405                 410                 415     


Lys Thr Val Ala Ala Asp Arg Lys Arg Ile Leu Cys Arg Ser Val Leu 
            420                 425                 430         


Met Phe Asn Lys Gly Thr Ala Gly Ser Glu Ser Ala Arg Lys Leu Tyr 
        435                 440                 445             


Glu Leu Cys Lys Thr Arg Met Pro Val Glu Glu Pro Asp Ser Ser Arg 
    450                 455                 460                 


Glu Asp Gly Val Val Gly Thr Ser Gly Ser Glu Glu Glu Ile Ser Gly 
465                 470                 475                 480 


Lys Asp Gly Gly Thr Ser Phe Ser Val Ser Asp Ala Asp Tyr Trp Glu 
                485                 490                 495     


Trp Asp Val Pro Pro Lys Val Leu Glu Glu Ser Ser Gly Asp Leu Leu 
            500                 505                 510         


Tyr Asp Thr Ala Val Asp Leu His Thr Lys Arg Lys Ser Pro Phe Tyr 
        515                 520                 525             


Gln Val Gly Ser 
    530         


<210>  62
<211>  607
<212>  PRT
<213>  Trypanosoma vivax

<400>  62

Met Glu Val Met Leu Phe Asp Tyr Phe His Val Leu Pro Ile Ser Cys 
1               5                   10                  15      


Lys Pro Arg Asn Phe Cys Ile Ala Phe Met Leu Met Phe Leu Arg Phe 
            20                  25                  30          


Cys Pro Val Phe Ala Met Arg Cys His Glu Pro Pro Thr Pro Pro Gln 
        35                  40                  45              


Leu Ser Ala Thr Cys Cys Val Ala Glu Glu Ile Asp Thr Tyr Asn Lys 
    50                  55                  60                  


His Leu Asp Ala Leu Met Gln Ile Ile Gly Asp Ala Ile Lys Asn Ile 
65                  70                  75                  80  


Ser Thr Asn Glu Asp Asn Ala Arg Ala Arg Ala Glu Gly Leu Lys Gly 
                85                  90                  95      


Cys Asn Leu His Tyr Val Gln Phe Ala Val Ala His Thr Glu Gly Ser 
            100                 105                 110         


Val Val Ala Ala Arg Arg Glu Ala Val Lys Ala Gln Asn Thr Ile Lys 
        115                 120                 125             


Gly Ser Thr Ser Leu Leu Lys Lys Val Thr Ile Asp Ile Ser Asn Ser 
    130                 135                 140                 


Phe Arg Asn Ile Ser Ser Lys Cys Asn Glu Leu Arg Glu Lys Tyr Pro 
145                 150                 155                 160 


Ser Leu Ile Pro Ala Asp Lys Asn Ser Pro Pro Asn Ile Thr Phe Lys 
                165                 170                 175     


Lys Ala Val Gln Leu Tyr Val Lys Asn Phe Ser Thr Cys Asn Val Met 
            180                 185                 190         


Tyr Ala Lys Lys Leu Leu Arg Leu Val Ala Gln Ser Glu Lys Ile Glu 
        195                 200                 205             


Ala Glu Val Ser Arg Ala Val Glu Arg Thr Asn Ala Ser Thr Met Glu 
    210                 215                 220                 


Leu Ala Lys Leu Asp Lys Val Ala Val Gln Leu Asn Lys Asp Ile Thr 
225                 230                 235                 240 


Ser Asn Arg Thr Trp Ala Gly Cys Lys Leu Ala Glu Tyr His Gly Gln 
                245                 250                 255     


Met Asn Phe Val Phe Met Gly Phe Tyr Val Leu Leu Ser Asp Ile Leu 
            260                 265                 270         


Asp Glu Leu His Ser Leu Leu Lys Lys Ser Lys Ser Met Gln Pro Thr 
        275                 280                 285             


Arg Leu Thr Gln Glu Glu Val Arg Arg Ala Leu Ser Lys Ala Glu Gln 
    290                 295                 300                 


Val Cys His Asp Val Ser Arg Phe Val Lys Ser Leu Gly Ser Thr Leu 
305                 310                 315                 320 


Arg Asp Phe Thr Asn Phe Val His Arg Leu Arg Lys Glu Tyr Leu His 
                325                 330                 335     


Gly Ile Leu Arg Asn Ala Ser Gly Phe Arg Glu Ser Phe Glu Arg Cys 
            340                 345                 350         


Tyr Lys Val Ala Thr Asn Asn Ser Val Thr Arg Leu Glu Ser Thr Val 
        355                 360                 365             


Glu Glu Ile Thr Ala Asn Asn Glu Asn Ile Ala Ala Trp Glu Ser Met 
    370                 375                 380                 


Thr Val His Gln Trp Lys Asp Val Ser Lys Lys Leu Arg Gln Ser Leu 
385                 390                 395                 400 


Leu Thr Val Leu Gly Gly Ser Asn Glu Tyr Ile Leu Leu Tyr Gly Tyr 
                405                 410                 415     


Phe Gln Glu Phe Asp Ser Met Ser Val Arg Glu Phe Ser Asn Thr Val 
            420                 425                 430         


Arg Ala Phe Arg Gln Ser Ile Thr Glu Met Ser Val Ala Arg Asn Val 
        435                 440                 445             


Val Gly Val Ala Ala Lys Thr Val Ala Ala Asp Arg Lys Arg Ile Leu 
    450                 455                 460                 


Cys Arg Ser Val Leu Met Phe Asn Lys Gly Thr Ala Gly Ser Glu Ser 
465                 470                 475                 480 


Ala Arg Lys Leu Tyr Glu Leu Cys Lys Thr Arg Met Pro Val Glu Glu 
                485                 490                 495     


Pro Asp Ser Ser Arg Glu Asp Gly Val Val Gly Thr Ser Gly Ser Glu 
            500                 505                 510         


Glu Glu Ile Ser Gly Lys Asp Gly Gly Thr Ser Phe Ser Val Ser Asp 
        515                 520                 525             


Ala Asp Tyr Trp Glu Trp Asp Val Pro Pro Lys Val Leu Glu Glu Ser 
    530                 535                 540                 


Ser Gly Asp Leu Leu Tyr Asp Thr Ala Val Asp Leu His Thr Lys Arg 
545                 550                 555                 560 


Lys Ser Pro Phe Tyr Gln Val Gly Ser Ile Ala Phe Gly Val Phe Leu 
                565                 570                 575     


Leu Val Val Ser Cys Gly Val Gly Ile Leu Met Phe Val Arg Arg Trp 
            580                 585                 590         


Tyr Ala Ala Cys Val Ala Arg Ser Ala Asp Gly Gly Thr Asp Cys 
        595                 600                 605         


