                         SEQUENCE LISTING

<110>  ADC Therapeutics SA
 
<120>  GLYCOCONJUGATES

<130>  008101230

<150>  US63/092640
<151>  2020-10-16

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  1

Met Ile His Thr Asn Leu Lys Lys Lys Phe Ser Cys Cys Val Leu Val 
1               5                   10                  15      


Phe Leu Leu Phe Ala Val Ile Cys Val Trp Lys Glu Lys Lys Lys Gly 
            20                  25                  30          


Ser Tyr Tyr Asp Ser Phe Lys Leu Gln Thr Lys Glu Phe Gln Val Leu 
        35                  40                  45              


Lys Ser Leu Gly Lys Leu Ala Met Gly Ser Asp Ser Gln Ser Val Ser 
    50                  55                  60                  


Ser Ser Ser Thr Gln Asp Pro His Arg Gly Arg Gln Thr Leu Gly Ser 
65                  70                  75                  80  


Leu Arg Gly Leu Ala Lys Ala Lys Pro Glu Ala Ser Phe Gln Val Trp 
                85                  90                  95      


Asn Lys Asp Ser Ser Ser Lys Asn Leu Ile Pro Arg Leu Gln Lys Ile 
            100                 105                 110         


Trp Lys Asn Tyr Leu Ser Met Asn Lys Tyr Lys Val Ser Tyr Lys Gly 
        115                 120                 125             


Pro Gly Pro Gly Ile Lys Phe Ser Ala Glu Ala Leu Arg Cys His Leu 
    130                 135                 140                 


Arg Asp His Val Asn Val Ser Met Val Glu Val Thr Asp Phe Pro Phe 
145                 150                 155                 160 


Asn Thr Ser Glu Trp Glu Gly Tyr Leu Pro Lys Glu Ser Ile Arg Thr 
                165                 170                 175     


Lys Ala Gly Pro Trp Gly Arg Cys Ala Val Val Ser Ser Ala Gly Ser 
            180                 185                 190         


Leu Lys Ser Ser Gln Leu Gly Arg Glu Ile Asp Asp His Asp Ala Val 
        195                 200                 205             


Leu Arg Phe Asn Gly Ala Pro Thr Ala Asn Phe Gln Gln Asp Val Gly 
    210                 215                 220                 


Thr Lys Thr Thr Ile Arg Leu Met Asn Ser Gln Leu Val Thr Thr Glu 
225                 230                 235                 240 


Lys Arg Phe Leu Lys Asp Ser Leu Tyr Asn Glu Gly Ile Leu Ile Val 
                245                 250                 255     


Trp Asp Pro Ser Val Tyr His Ser Asp Ile Pro Lys Trp Tyr Gln Asn 
            260                 265                 270         


Pro Asp Tyr Asn Phe Phe Asn Asn Tyr Lys Thr Tyr Arg Lys Leu His 
        275                 280                 285             


Pro Asn Gln Pro Phe Tyr Ile Leu Lys Pro Gln Met Pro Trp Glu Leu 
    290                 295                 300                 


Trp Asp Ile Leu Gln Glu Ile Ser Pro Glu Glu Ile Gln Pro Asn Pro 
305                 310                 315                 320 


Pro Ser Ser Gly Met Leu Gly Ile Ile Ile Met Met Thr Leu Cys Asp 
                325                 330                 335     


Gln Val Asp Ile Tyr Glu Phe Leu Pro Ser Lys Arg Lys Thr Asp Val 
            340                 345                 350         


Cys Tyr Tyr Tyr Gln Lys Phe Phe Asp Ser Ala Cys Thr Met Gly Ala 
        355                 360                 365             


Tyr His Pro Leu Leu Tyr Glu Lys Asn Leu Val Lys His Leu Asn Gln 
    370                 375                 380                 


Gly Thr Asp Glu Asp Ile Tyr Leu Leu Gly Lys Ala Thr Leu Pro Gly 
385                 390                 395                 400 


Phe Arg Thr Ile His Cys 
                405     


<210>  2
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  2

Met Arg Leu Arg Glu Pro Leu Leu Ser Gly Ser Ala Ala Met Pro Gly 
1               5                   10                  15      


Ala Ser Leu Gln Arg Ala Cys Arg Leu Leu Val Ala Val Cys Ala Leu 
            20                  25                  30          


His Leu Gly Val Thr Leu Val Tyr Tyr Leu Ala Gly Arg Asp Leu Ser 
        35                  40                  45              


Arg Leu Pro Gln Leu Val Gly Val Ser Thr Pro Leu Gln Gly Gly Ser 
    50                  55                  60                  


Asn Ser Ala Ala Ala Ile Gly Gln Ser Ser Gly Glu Leu Arg Thr Gly 
65                  70                  75                  80  


Gly Ala Arg Pro Pro Pro Pro Leu Gly Ala Ser Ser Gln Pro Arg Pro 
                85                  90                  95      


Gly Gly Asp Ser Ser Pro Val Val Asp Ser Gly Pro Gly Pro Ala Ser 
            100                 105                 110         


Asn Leu Thr Ser Val Pro Val Pro His Thr Thr Ala Leu Ser Leu Pro 
        115                 120                 125             


Ala Cys Pro Glu Glu Ser Pro Leu Leu Val Gly Pro Met Leu Ile Glu 
    130                 135                 140                 


Phe Asn Met Pro Val Asp Leu Glu Leu Val Ala Lys Gln Asn Pro Asn 
145                 150                 155                 160 


Val Lys Met Gly Gly Arg Tyr Ala Pro Arg Asp Cys Val Ser Pro His 
                165                 170                 175     


Lys Val Ala Ile Ile Ile Pro Phe Arg Asn Arg Gln Glu His Leu Lys 
            180                 185                 190         


Tyr Trp Leu Tyr Tyr Leu His Pro Val Leu Gln Arg Gln Gln Leu Asp 
        195                 200                 205             


Tyr Gly Ile Tyr Val Ile Asn Gln Ala Gly Asp Thr Ile Phe Asn Arg 
    210                 215                 220                 


Ala Lys Leu Leu Asn Val Gly Phe Gln Glu Ala Leu Lys Asp Tyr Asp 
225                 230                 235                 240 


Tyr Thr Cys Phe Val Phe Ser Asp Val Asp Leu Ile Pro Met Asn Asp 
                245                 250                 255     


His Asn Ala Tyr Arg Cys Phe Ser Gln Pro Arg His Ile Ser Val Ala 
            260                 265                 270         


Met Asp Lys Phe Gly Phe Ser Leu Pro Tyr Val Gln Tyr Phe Gly Gly 
        275                 280                 285             


Val Ser Ala Leu Ser Lys Gln Gln Phe Leu Thr Ile Asn Gly Phe Pro 
    290                 295                 300                 


Asn Asn Tyr Trp Gly Trp Gly Gly Glu Asp Asp Asp Ile Phe Asn Arg 
305                 310                 315                 320 


Leu Val Phe Arg Gly Met Ser Ile Ser Arg Pro Asn Ala Val Val Gly 
                325                 330                 335     


Arg Cys Arg Met Ile Arg His Ser Arg Asp Lys Lys Asn Glu Pro Asn 
            340                 345                 350         


Pro Gln Arg Phe Asp Arg Ile Ala His Thr Lys Glu Thr Met Leu Ser 
        355                 360                 365             


Asp Gly Leu Asn Ser Leu Thr Tyr Gln Val Leu Asp Val Gln Arg Tyr 
    370                 375                 380                 


Pro Leu Tyr Thr Gln Ile Thr Val Asp Ile Gly Thr Pro Ser 
385                 390                 395             


<210>  3
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  3

Met Asp Lys His Leu Leu Val Lys Arg Thr Leu Gly Cys Val Cys Ala 
1               5                   10                  15      


Ala Thr Leu Met Gly Ala Ala Leu Ala Thr His His Asp Ser Leu Asn 
            20                  25                  30          


Thr Val Lys Ala Glu Glu Lys Thr Val Gln Val Gln Lys Gly Leu Pro 
        35                  40                  45              


Ser Ile Asp Ser Leu His Tyr Leu Ser Glu Asn Ser Lys Lys Glu Phe 
    50                  55                  60                  


Lys Glu Glu Leu Ser Lys Ala Gly Gln Glu Ser Gln Lys Val Lys Glu 
65                  70                  75                  80  


Ile Leu Ala Lys Ala Gln Gln Ala Asp Lys Gln Ala Gln Glu Leu Ala 
                85                  90                  95      


Lys Met Lys Ile Pro Glu Lys Ile Pro Met Lys Pro Leu His Gly Pro 
            100                 105                 110         


Leu Tyr Gly Gly Tyr Phe Arg Thr Trp His Asp Lys Thr Ser Asp Pro 
        115                 120                 125             


Thr Glu Lys Asp Lys Val Asn Ser Met Gly Glu Leu Pro Lys Glu Val 
    130                 135                 140                 


Asp Leu Ala Phe Ile Phe His Asp Trp Thr Lys Asp Tyr Ser Leu Phe 
145                 150                 155                 160 


Trp Lys Glu Leu Ala Thr Lys His Val Pro Lys Leu Asn Lys Gln Gly 
                165                 170                 175     


Thr Arg Val Ile Arg Thr Ile Pro Trp Arg Phe Leu Ala Gly Gly Asp 
            180                 185                 190         


Asn Ser Gly Ile Ala Glu Asp Thr Ser Lys Tyr Pro Asn Thr Pro Glu 
        195                 200                 205             


Gly Asn Lys Ala Leu Ala Lys Ala Ile Val Asp Glu Tyr Val Tyr Lys 
    210                 215                 220                 


Tyr Asn Leu Asp Gly Leu Asp Val Asp Val Glu His Asp Ser Ile Pro 
225                 230                 235                 240 


Lys Val Asp Lys Lys Glu Asp Thr Ala Gly Val Glu Arg Ser Ile Gln 
                245                 250                 255     


Val Phe Glu Glu Ile Gly Lys Leu Ile Gly Pro Lys Gly Val Asp Lys 
            260                 265                 270         


Ser Arg Leu Phe Ile Met Asp Ser Thr Tyr Met Ala Asp Lys Asn Pro 
        275                 280                 285             


Leu Ile Glu Arg Gly Ala Pro Tyr Ile Asn Leu Leu Leu Val Gln Val 
    290                 295                 300                 


Tyr Gly Ser Gln Gly Glu Lys Gly Gly Trp Glu Pro Val Ser Asn Arg 
305                 310                 315                 320 


Pro Glu Lys Thr Met Glu Glu Arg Trp Gln Gly Tyr Ser Lys Tyr Ile 
                325                 330                 335     


Arg Pro Glu Gln Tyr Met Ile Gly Phe Ser Phe Tyr Glu Glu Asn Ala 
            340                 345                 350         


Gln Glu Gly Asn Leu Trp Tyr Asp Ile Asn Ser Arg Lys Asp Glu Asp 
        355                 360                 365             


Lys Ala Asn Gly Ile Asn Thr Asp Ile Thr Gly Thr Arg Ala Glu Arg 
    370                 375                 380                 


Tyr Ala Arg Trp Gln Pro Lys Thr Gly Gly Val Lys Gly Gly Ile Phe 
385                 390                 395                 400 


Ser Tyr Ala Ile Asp Arg Asp Gly Val Ala His Gln Pro Lys Lys Tyr 
                405                 410                 415     


Ala Lys Gln Lys Glu Phe Lys Asp Ala Thr Asp Asn Ile Phe His Ser 
            420                 425                 430         


Asp Tyr Ser Val Ser Lys Ala Leu Lys Thr Val Met Leu Lys Asp Lys 
        435                 440                 445             


Ser Tyr Asp Leu Ile Asp Glu Lys Asp Phe Pro Asp Lys Ala Leu Arg 
    450                 455                 460                 


Glu Ala Val Met Ala Gln Val Gly Thr Arg Lys Gly Asp Leu Glu Arg 
465                 470                 475                 480 


Phe Asn Gly Thr Leu Arg Leu Asp Asn Pro Ala Ile Gln Ser Leu Glu 
                485                 490                 495     


Gly Leu Asn Lys Phe Lys Lys Leu Ala Gln Leu Asp Leu Ile Gly Leu 
            500                 505                 510         


Ser Arg Ile Thr Lys Leu Asp Arg Ser Val Leu Pro Ala Asn Met Lys 
        515                 520                 525             


Pro Gly Lys Asp Thr Leu Glu Thr Val Leu Glu Thr Tyr Lys Lys Asp 
    530                 535                 540                 


Asn Lys Glu Glu Pro Ala Thr Ile Pro Pro Val Ser Leu Lys Val Ser 
545                 550                 555                 560 


Gly Leu Thr Gly Leu Lys Glu Leu Asp Leu Ser Gly Phe Asp Arg Glu 
                565                 570                 575     


Thr Leu Ala Gly Leu Asp Ala Ala Thr Leu Thr Ser Leu Glu Lys Val 
            580                 585                 590         


Asp Ile Ser Gly Asn Lys Leu Asp Leu Ala Pro Gly Thr Glu Asn Arg 
        595                 600                 605             


Gln Ile Phe Asp Thr Met Leu Ser Thr Ile Ser Asn His Val Gly Ser 
    610                 615                 620                 


Asn Glu Gln Thr Val Lys Phe Asp Lys Gln Lys Pro Thr Gly His Tyr 
625                 630                 635                 640 


Pro Asp Thr Tyr Gly Lys Thr Ser Leu Arg Leu Pro Val Ala Asn Glu 
                645                 650                 655     


Lys Val Asp Leu Gln Ser Gln Leu Leu Phe Gly Thr Val Thr Asn Gln 
            660                 665                 670         


Gly Thr Leu Ile Asn Ser Glu Ala Asp Tyr Lys Ala Tyr Gln Asn His 
        675                 680                 685             


Lys Ile Ala Gly Arg Ser Phe Val Asp Ser Asn Tyr His Tyr Asn Asn 
    690                 695                 700                 


Phe Lys Val Ser Tyr Glu Asn Tyr Thr Val Lys Val Thr Asp Ser Thr 
705                 710                 715                 720 


Leu Gly Thr Thr Thr Asp Lys Thr Leu Ala Thr Asp Lys Glu Glu Thr 
                725                 730                 735     


Tyr Lys Val Asp Phe Phe Ser Pro Ala Asp Lys Thr Lys Ala Val His 
            740                 745                 750         


Thr Ala Lys Val Ile Val Gly Asp Glu Lys Thr Met Met Val Asn Leu 
        755                 760                 765             


Ala Glu Gly Ala Thr Val Ile Gly Gly Ser Ala Asp Pro Val Asn Ala 
    770                 775                 780                 


Arg Lys Val Phe Asp Gly Gln Leu Gly Ser Glu Thr Asp Asn Ile Ser 
785                 790                 795                 800 


Leu Gly Trp Asp Ser Lys Gln Ser Ile Ile Phe Lys Leu Lys Glu Asp 
                805                 810                 815     


Gly Leu Ile Lys His Trp Arg Phe Phe Asn Asp Ser Ala Arg Asn Pro 
            820                 825                 830         


Glu Thr Thr Asn Lys Pro Ile Gln Glu Ala Ser Leu Gln Ile Phe Asn 
        835                 840                 845             


Ile Lys Asp Tyr Asn Leu Asp Asn Leu Leu Glu Asn Pro Asn Lys Phe 
    850                 855                 860                 


Asp Asp Glu Lys Tyr Trp Ile Thr Val Asp Thr Tyr Ser Ala Gln Gly 
865                 870                 875                 880 


Glu Arg Ala Thr Ala Phe Ser Asn Thr Leu Asn Asn Ile Thr Ser Lys 
                885                 890                 895     


Tyr Trp Arg Val Val Phe Asp Thr Lys Gly Asp Arg Tyr Ser Ser Pro 
            900                 905                 910         


Val Val Pro Glu Leu Gln Ile Leu Gly Tyr Pro Leu Pro Asn Ala Asp 
        915                 920                 925             


Thr Ile Met Lys Thr Val Thr Thr Ala Lys Glu Leu Ser Gln Gln Lys 
    930                 935                 940                 


Asp Lys Phe Ser Gln Lys Met Leu Asp Glu Leu Lys Ile Lys Glu Met 
945                 950                 955                 960 


Ala Leu Glu Thr Ser Leu Asn Ser Lys Ile Phe Asp Val Thr Ala Ile 
                965                 970                 975     


Asn Ala Asn Ala Gly Val Leu Lys Asp Cys Ile Glu Lys Arg Gln Leu 
            980                 985                 990         


Leu Lys Lys 
        995 


<210>  4
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  4

His His His His His His Trp Ser His Pro Gln Phe Glu Lys Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Ser Gly Gly Ser Ser Ala Trp Ser His Pro Gln 
            20                  25                  30          


Phe Glu Lys Phe Gln Val Leu Lys Ser Leu Gly Lys Leu Ala Met Gly 
        35                  40                  45              


Ser Asp Ser Gln Ser Val Ser Ser Ser Ser Thr Gln Asp Pro His Arg 
    50                  55                  60                  


Gly Arg Gln Thr Leu Gly Ser Leu Arg Gly Leu Ala Lys Ala Lys Pro 
65                  70                  75                  80  


Glu Ala Ser Phe Gln Val Trp Asn Lys Asp Ser Ser Ser Lys Asn Leu 
                85                  90                  95      


Ile Pro Arg Leu Gln Lys Ile Trp Lys Asn Tyr Leu Ser Met Asn Lys 
            100                 105                 110         


Tyr Lys Val Ser Tyr Lys Gly Pro Gly Pro Gly Ile Lys Phe Ser Ala 
        115                 120                 125             


Glu Ala Leu Arg Cys His Leu Arg Asp His Val Asn Val Ser Met Val 
    130                 135                 140                 


Glu Val Thr Asp Phe Pro Phe Asn Thr Ser Glu Trp Glu Gly Tyr Leu 
145                 150                 155                 160 


Pro Lys Glu Ser Ile Arg Thr Lys Ala Gly Pro Trp Gly Arg Cys Ala 
                165                 170                 175     


Val Val Ser Ser Ala Gly Ser Leu Lys Ser Ser Gln Leu Gly Arg Glu 
            180                 185                 190         


Ile Asp Asp His Asp Ala Val Leu Arg Phe Asn Gly Ala Pro Thr Ala 
        195                 200                 205             


Asn Phe Gln Gln Asp Val Gly Thr Lys Thr Thr Ile Arg Leu Met Asn 
    210                 215                 220                 


Ser Gln Leu Val Thr Thr Glu Lys Arg Phe Leu Lys Asp Ser Leu Tyr 
225                 230                 235                 240 


Asn Glu Gly Ile Leu Ile Val Trp Asp Pro Ser Val Tyr His Ser Asp 
                245                 250                 255     


Ile Pro Lys Trp Tyr Gln Asn Pro Asp Tyr Asn Phe Phe Asn Asn Tyr 
            260                 265                 270         


Lys Thr Tyr Arg Lys Leu His Pro Asn Gln Pro Phe Tyr Ile Leu Lys 
        275                 280                 285             


Pro Gln Met Pro Trp Glu Leu Trp Asp Ile Leu Gln Glu Ile Ser Pro 
    290                 295                 300                 


Glu Glu Ile Gln Pro Asn Pro Pro Ser Ser Gly Met Leu Gly Ile Ile 
305                 310                 315                 320 


Ile Met Met Thr Leu Cys Asp Gln Val Asp Ile Tyr Glu Phe Leu Pro 
                325                 330                 335     


Ser Lys Arg Lys Thr Asp Val Cys Tyr Tyr Tyr Gln Lys Phe Phe Asp 
            340                 345                 350         


Ser Ala Cys Thr Met Gly Ala Tyr His Pro Leu Leu Tyr Glu Lys Asn 
        355                 360                 365             


Leu Val Lys His Leu Asn Gln Gly Thr Asp Glu Asp Ile Tyr Leu Leu 
    370                 375                 380                 


Gly Lys Ala Thr Leu Pro Gly Phe Arg Thr Ile His Cys 
385                 390                 395         


<210>  5
<211>  364
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  5

His His His His His His His His His His Arg Asp Leu Ser Arg Leu 
1               5                   10                  15      


Pro Gln Leu Val Gly Val Ser Thr Pro Leu Gln Gly Gly Ser Asn Ser 
            20                  25                  30          


Ala Ala Ala Ile Gly Gln Ser Ser Gly Glu Leu Arg Thr Gly Gly Ala 
        35                  40                  45              


Arg Pro Pro Pro Pro Leu Gly Ala Ser Ser Gln Pro Arg Pro Gly Gly 
    50                  55                  60                  


Asp Ser Ser Pro Val Val Asp Ser Gly Pro Gly Pro Ala Ser Asn Leu 
65                  70                  75                  80  


Thr Ser Val Pro Val Pro His Thr Thr Ala Leu Ser Leu Pro Ala Cys 
                85                  90                  95      


Pro Glu Glu Ser Pro Leu Leu Val Gly Pro Met Leu Ile Glu Phe Asn 
            100                 105                 110         


Met Pro Val Asp Leu Glu Leu Val Ala Lys Gln Asn Pro Asn Val Lys 
        115                 120                 125             


Met Gly Gly Arg Tyr Ala Pro Arg Asp Cys Val Ser Pro His Lys Val 
    130                 135                 140                 


Ala Ile Ile Ile Pro Phe Arg Asn Arg Gln Glu His Leu Lys Tyr Trp 
145                 150                 155                 160 


Leu Tyr Tyr Leu His Pro Val Leu Gln Arg Gln Gln Leu Asp Tyr Gly 
                165                 170                 175     


Ile Tyr Val Ile Asn Gln Ala Gly Asp Thr Ile Phe Asn Arg Ala Lys 
            180                 185                 190         


Leu Leu Asn Val Gly Phe Gln Glu Ala Leu Lys Asp Tyr Asp Tyr Thr 
        195                 200                 205             


Cys Phe Val Phe Ser Asp Val Asp Leu Ile Pro Met Asn Asp His Asn 
    210                 215                 220                 


Ala Tyr Arg Cys Phe Ser Gln Pro Arg His Ile Ser Val Ala Met Asp 
225                 230                 235                 240 


Lys Phe Gly Phe Ser Leu Pro Tyr Val Gln Tyr Phe Gly Gly Val Ser 
                245                 250                 255     


Ala Leu Ser Lys Gln Gln Phe Leu Thr Ile Asn Gly Phe Pro Asn Asn 
            260                 265                 270         


Tyr Trp Gly Trp Gly Gly Glu Asp Asp Asp Ile Phe Asn Arg Leu Val 
        275                 280                 285             


Phe Arg Gly Met Ser Ile Ser Arg Pro Asn Ala Val Val Gly Arg Cys 
    290                 295                 300                 


Arg Met Ile Arg His Ser Arg Asp Lys Lys Asn Glu Pro Asn Pro Gln 
305                 310                 315                 320 


Arg Phe Asp Arg Ile Ala His Thr Lys Glu Thr Met Leu Ser Asp Gly 
                325                 330                 335     


Leu Asn Ser Leu Thr Tyr Gln Val Leu Asp Val Gln Arg Tyr Pro Leu 
            340                 345                 350         


Tyr Thr Gln Ile Thr Val Asp Ile Gly Thr Pro Ser 
        355                 360                 


<210>  6
<211>  969
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  6

Glu Glu Lys Thr Val Gln Val Gln Lys Gly Leu Pro Ser Ile Asp Ser 
1               5                   10                  15      


Leu His Tyr Leu Ser Glu Asn Ser Lys Lys Glu Phe Lys Glu Glu Leu 
            20                  25                  30          


Ser Lys Ala Gly Gln Glu Ser Gln Lys Val Lys Glu Ile Leu Ala Lys 
        35                  40                  45              


Ala Gln Gln Ala Asp Lys Gln Ala Gln Glu Leu Ala Lys Met Lys Ile 
    50                  55                  60                  


Pro Glu Lys Ile Pro Met Lys Pro Leu His Gly Pro Leu Tyr Gly Gly 
65                  70                  75                  80  


Tyr Phe Arg Thr Trp His Asp Lys Thr Ser Asp Pro Thr Glu Lys Asp 
                85                  90                  95      


Lys Val Asn Ser Met Gly Glu Leu Pro Lys Glu Val Asp Leu Ala Phe 
            100                 105                 110         


Ile Phe His Asp Trp Thr Lys Asp Tyr Ser Leu Phe Trp Lys Glu Leu 
        115                 120                 125             


Ala Thr Lys His Val Pro Lys Leu Asn Lys Gln Gly Thr Arg Val Ile 
    130                 135                 140                 


Arg Thr Ile Pro Trp Arg Phe Leu Ala Gly Gly Asp Asn Ser Gly Ile 
145                 150                 155                 160 


Ala Glu Asp Thr Ser Lys Tyr Pro Asn Thr Pro Glu Gly Asn Lys Ala 
                165                 170                 175     


Leu Ala Lys Ala Ile Val Asp Glu Tyr Val Tyr Lys Tyr Asn Leu Asp 
            180                 185                 190         


Gly Leu Asp Val Asp Val Glu His Asp Ser Ile Pro Lys Val Asp Lys 
        195                 200                 205             


Lys Glu Asp Thr Ala Gly Val Glu Arg Ser Ile Gln Val Phe Glu Glu 
    210                 215                 220                 


Ile Gly Lys Leu Ile Gly Pro Lys Gly Val Asp Lys Ser Arg Leu Phe 
225                 230                 235                 240 


Ile Met Asp Ser Thr Tyr Met Ala Asp Lys Asn Pro Leu Ile Glu Arg 
                245                 250                 255     


Gly Ala Pro Tyr Ile Asn Leu Leu Leu Val Gln Val Tyr Gly Ser Gln 
            260                 265                 270         


Gly Glu Lys Gly Gly Trp Glu Pro Val Ser Asn Arg Pro Glu Lys Thr 
        275                 280                 285             


Met Glu Glu Arg Trp Gln Gly Tyr Ser Lys Tyr Ile Arg Pro Glu Gln 
    290                 295                 300                 


Tyr Met Ile Gly Phe Ser Phe Tyr Glu Glu Asn Ala Gln Glu Gly Asn 
305                 310                 315                 320 


Leu Trp Tyr Asp Ile Asn Ser Arg Lys Asp Glu Asp Lys Ala Asn Gly 
                325                 330                 335     


Ile Asn Thr Asp Ile Thr Gly Thr Arg Ala Glu Arg Tyr Ala Arg Trp 
            340                 345                 350         


Gln Pro Lys Thr Gly Gly Val Lys Gly Gly Ile Phe Ser Tyr Ala Ile 
        355                 360                 365             


Asp Arg Asp Gly Val Ala His Gln Pro Lys Lys Tyr Ala Lys Gln Lys 
    370                 375                 380                 


Glu Phe Lys Asp Ala Thr Asp Asn Ile Phe His Ser Asp Tyr Ser Val 
385                 390                 395                 400 


Ser Lys Ala Leu Lys Thr Val Met Leu Lys Asp Lys Ser Tyr Asp Leu 
                405                 410                 415     


Ile Asp Glu Lys Asp Phe Pro Asp Lys Ala Leu Arg Glu Ala Val Met 
            420                 425                 430         


Ala Gln Val Gly Thr Arg Lys Gly Asp Leu Glu Arg Phe Asn Gly Thr 
        435                 440                 445             


Leu Arg Leu Asp Asn Pro Ala Ile Gln Ser Leu Glu Gly Leu Asn Lys 
    450                 455                 460                 


Phe Lys Lys Leu Ala Gln Leu Asp Leu Ile Gly Leu Ser Arg Ile Thr 
465                 470                 475                 480 


Lys Leu Asp Arg Ser Val Leu Pro Ala Asn Met Lys Pro Gly Lys Asp 
                485                 490                 495     


Thr Leu Glu Thr Val Leu Glu Thr Tyr Lys Lys Asp Asn Lys Glu Glu 
            500                 505                 510         


Pro Ala Thr Ile Pro Pro Val Ser Leu Lys Val Ser Gly Leu Thr Gly 
        515                 520                 525             


Leu Lys Glu Leu Asp Leu Ser Gly Phe Asp Arg Glu Thr Leu Ala Gly 
    530                 535                 540                 


Leu Asp Ala Ala Thr Leu Thr Ser Leu Glu Lys Val Asp Ile Ser Gly 
545                 550                 555                 560 


Asn Lys Leu Asp Leu Ala Pro Gly Thr Glu Asn Arg Gln Ile Phe Asp 
                565                 570                 575     


Thr Met Leu Ser Thr Ile Ser Asn His Val Gly Ser Asn Glu Gln Thr 
            580                 585                 590         


Val Lys Phe Asp Lys Gln Lys Pro Thr Gly His Tyr Pro Asp Thr Tyr 
        595                 600                 605             


Gly Lys Thr Ser Leu Arg Leu Pro Val Ala Asn Glu Lys Val Asp Leu 
    610                 615                 620                 


Gln Ser Gln Leu Leu Phe Gly Thr Val Thr Asn Gln Gly Thr Leu Ile 
625                 630                 635                 640 


Asn Ser Glu Ala Asp Tyr Lys Ala Tyr Gln Asn His Lys Ile Ala Gly 
                645                 650                 655     


Arg Ser Phe Val Asp Ser Asn Tyr His Tyr Asn Asn Phe Lys Val Ser 
            660                 665                 670         


Tyr Glu Asn Tyr Thr Val Lys Val Thr Asp Ser Thr Leu Gly Thr Thr 
        675                 680                 685             


Thr Asp Lys Thr Leu Ala Thr Asp Lys Glu Glu Thr Tyr Lys Val Asp 
    690                 695                 700                 


Phe Phe Ser Pro Ala Asp Lys Thr Lys Ala Val His Thr Ala Lys Val 
705                 710                 715                 720 


Ile Val Gly Asp Glu Lys Thr Met Met Val Asn Leu Ala Glu Gly Ala 
                725                 730                 735     


Thr Val Ile Gly Gly Ser Ala Asp Pro Val Asn Ala Arg Lys Val Phe 
            740                 745                 750         


Asp Gly Gln Leu Gly Ser Glu Thr Asp Asn Ile Ser Leu Gly Trp Asp 
        755                 760                 765             


Ser Lys Gln Ser Ile Ile Phe Lys Leu Lys Glu Asp Gly Leu Ile Lys 
    770                 775                 780                 


His Trp Arg Phe Phe Asn Asp Ser Ala Arg Asn Pro Glu Thr Thr Asn 
785                 790                 795                 800 


Lys Pro Ile Gln Glu Ala Ser Leu Gln Ile Phe Asn Ile Lys Asp Tyr 
                805                 810                 815     


Asn Leu Asp Asn Leu Leu Glu Asn Pro Asn Lys Phe Asp Asp Glu Lys 
            820                 825                 830         


Tyr Trp Ile Thr Val Asp Thr Tyr Ser Ala Gln Gly Glu Arg Ala Thr 
        835                 840                 845             


Ala Phe Ser Asn Thr Leu Asn Asn Ile Thr Ser Lys Tyr Trp Arg Val 
    850                 855                 860                 


Val Phe Asp Thr Lys Gly Asp Arg Tyr Ser Ser Pro Val Val Pro Glu 
865                 870                 875                 880 


Leu Gln Ile Leu Gly Tyr Pro Leu Pro Asn Ala Asp Thr Ile Met Lys 
                885                 890                 895     


Thr Val Thr Thr Ala Lys Glu Leu Ser Gln Gln Lys Asp Lys Phe Ser 
            900                 905                 910         


Gln Lys Met Leu Asp Glu Leu Lys Ile Lys Glu Met Ala Leu Glu Thr 
        915                 920                 925             


Ser Leu Asn Ser Lys Ile Phe Asp Val Thr Ala Ile Asn Ala Asn Ala 
    930                 935                 940                 


Gly Val Leu Lys Asp Cys Ile Glu Lys Arg Gln Leu Leu Lys Lys His 
945                 950                 955                 960 


His His His His His His His His His 
                965                 


<210>  7
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  7

Phe Gln Val Leu Lys Ser Leu Gly Lys Leu Ala Met Gly Ser Asp Ser 
1               5                   10                  15      


Gln Ser Val Ser Ser Ser Ser Thr Gln Asp Pro His Arg Gly Arg Gln 
            20                  25                  30          


Thr Leu Gly Ser Leu Arg Gly Leu Ala Lys Ala Lys Pro Glu Ala Ser 
        35                  40                  45              


Phe Gln Val Trp Asn Lys Asp Ser Ser Ser Lys Asn Leu Ile Pro Arg 
    50                  55                  60                  


Leu Gln Lys Ile Trp Lys Asn Tyr Leu Ser Met Asn Lys Tyr Lys Val 
65                  70                  75                  80  


Ser Tyr Lys Gly Pro Gly Pro Gly Ile Lys Phe Ser Ala Glu Ala Leu 
                85                  90                  95      


Arg Cys His Leu Arg Asp His Val Asn Val Ser Met Val Glu Val Thr 
            100                 105                 110         


Asp Phe Pro Phe Asn Thr Ser Glu Trp Glu Gly Tyr Leu Pro Lys Glu 
        115                 120                 125             


Ser Ile Arg Thr Lys Ala Gly Pro Trp Gly Arg Cys Ala Val Val Ser 
    130                 135                 140                 


Ser Ala Gly Ser Leu Lys Ser Ser Gln Leu Gly Arg Glu Ile Asp Asp 
145                 150                 155                 160 


His Asp Ala Val Leu Arg Phe Asn Gly Ala Pro Thr Ala Asn Phe Gln 
                165                 170                 175     


Gln Asp Val Gly Thr Lys Thr Thr Ile Arg Leu Met Asn Ser Gln Leu 
            180                 185                 190         


Val Thr Thr Glu Lys Arg Phe Leu Lys Asp Ser Leu Tyr Asn Glu Gly 
        195                 200                 205             


Ile Leu Ile Val Trp Asp Pro Ser Val Tyr His Ser Asp Ile Pro Lys 
    210                 215                 220                 


Trp Tyr Gln Asn Pro Asp Tyr Asn Phe Phe Asn Asn Tyr Lys Thr Tyr 
225                 230                 235                 240 


Arg Lys Leu His Pro Asn Gln Pro Phe Tyr Ile Leu Lys Pro Gln Met 
                245                 250                 255     


Pro Trp Glu Leu Trp Asp Ile Leu Gln Glu Ile Ser Pro Glu Glu Ile 
            260                 265                 270         


Gln Pro Asn Pro Pro Ser Ser Gly Met Leu Gly Ile Ile Ile Met Met 
        275                 280                 285             


Thr Leu Cys Asp Gln Val Asp Ile Tyr Glu Phe Leu Pro Ser Lys Arg 
    290                 295                 300                 


Lys Thr Asp Val Cys Tyr Tyr Tyr Gln Lys Phe Phe Asp Ser Ala Cys 
305                 310                 315                 320 


Thr Met Gly Ala Tyr His Pro Leu Leu Tyr Glu Lys Asn Leu Val Lys 
                325                 330                 335     


His Leu Asn Gln Gly Thr Asp Glu Asp Ile Tyr Leu Leu Gly Lys Ala 
            340                 345                 350         


Thr Leu Pro Gly Phe Arg Thr Ile His Cys 
        355                 360         


<210>  8
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  8

Arg Asp Leu Ser Arg Leu Pro Gln Leu Val Gly Val Ser Thr Pro Leu 
1               5                   10                  15      


Gln Gly Gly Ser Asn Ser Ala Ala Ala Ile Gly Gln Ser Ser Gly Glu 
            20                  25                  30          


Leu Arg Thr Gly Gly Ala Arg Pro Pro Pro Pro Leu Gly Ala Ser Ser 
        35                  40                  45              


Gln Pro Arg Pro Gly Gly Asp Ser Ser Pro Val Val Asp Ser Gly Pro 
    50                  55                  60                  


Gly Pro Ala Ser Asn Leu Thr Ser Val Pro Val Pro His Thr Thr Ala 
65                  70                  75                  80  


Leu Ser Leu Pro Ala Cys Pro Glu Glu Ser Pro Leu Leu Val Gly Pro 
                85                  90                  95      


Met Leu Ile Glu Phe Asn Met Pro Val Asp Leu Glu Leu Val Ala Lys 
            100                 105                 110         


Gln Asn Pro Asn Val Lys Met Gly Gly Arg Tyr Ala Pro Arg Asp Cys 
        115                 120                 125             


Val Ser Pro His Lys Val Ala Ile Ile Ile Pro Phe Arg Asn Arg Gln 
    130                 135                 140                 


Glu His Leu Lys Tyr Trp Leu Tyr Tyr Leu His Pro Val Leu Gln Arg 
145                 150                 155                 160 


Gln Gln Leu Asp Tyr Gly Ile Tyr Val Ile Asn Gln Ala Gly Asp Thr 
                165                 170                 175     


Ile Phe Asn Arg Ala Lys Leu Leu Asn Val Gly Phe Gln Glu Ala Leu 
            180                 185                 190         


Lys Asp Tyr Asp Tyr Thr Cys Phe Val Phe Ser Asp Val Asp Leu Ile 
        195                 200                 205             


Pro Met Asn Asp His Asn Ala Tyr Arg Cys Phe Ser Gln Pro Arg His 
    210                 215                 220                 


Ile Ser Val Ala Met Asp Lys Phe Gly Phe Ser Leu Pro Tyr Val Gln 
225                 230                 235                 240 


Tyr Phe Gly Gly Val Ser Ala Leu Ser Lys Gln Gln Phe Leu Thr Ile 
                245                 250                 255     


Asn Gly Phe Pro Asn Asn Tyr Trp Gly Trp Gly Gly Glu Asp Asp Asp 
            260                 265                 270         


Ile Phe Asn Arg Leu Val Phe Arg Gly Met Ser Ile Ser Arg Pro Asn 
        275                 280                 285             


Ala Val Val Gly Arg Cys Arg Met Ile Arg His Ser Arg Asp Lys Lys 
    290                 295                 300                 


Asn Glu Pro Asn Pro Gln Arg Phe Asp Arg Ile Ala His Thr Lys Glu 
305                 310                 315                 320 


Thr Met Leu Ser Asp Gly Leu Asn Ser Leu Thr Tyr Gln Val Leu Asp 
                325                 330                 335     


Val Gln Arg Tyr Pro Leu Tyr Thr Gln Ile Thr Val Asp Ile Gly Thr 
            340                 345                 350         


Pro Ser 
        


<210>  9
<211>  959
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  9

Glu Glu Lys Thr Val Gln Val Gln Lys Gly Leu Pro Ser Ile Asp Ser 
1               5                   10                  15      


Leu His Tyr Leu Ser Glu Asn Ser Lys Lys Glu Phe Lys Glu Glu Leu 
            20                  25                  30          


Ser Lys Ala Gly Gln Glu Ser Gln Lys Val Lys Glu Ile Leu Ala Lys 
        35                  40                  45              


Ala Gln Gln Ala Asp Lys Gln Ala Gln Glu Leu Ala Lys Met Lys Ile 
    50                  55                  60                  


Pro Glu Lys Ile Pro Met Lys Pro Leu His Gly Pro Leu Tyr Gly Gly 
65                  70                  75                  80  


Tyr Phe Arg Thr Trp His Asp Lys Thr Ser Asp Pro Thr Glu Lys Asp 
                85                  90                  95      


Lys Val Asn Ser Met Gly Glu Leu Pro Lys Glu Val Asp Leu Ala Phe 
            100                 105                 110         


Ile Phe His Asp Trp Thr Lys Asp Tyr Ser Leu Phe Trp Lys Glu Leu 
        115                 120                 125             


Ala Thr Lys His Val Pro Lys Leu Asn Lys Gln Gly Thr Arg Val Ile 
    130                 135                 140                 


Arg Thr Ile Pro Trp Arg Phe Leu Ala Gly Gly Asp Asn Ser Gly Ile 
145                 150                 155                 160 


Ala Glu Asp Thr Ser Lys Tyr Pro Asn Thr Pro Glu Gly Asn Lys Ala 
                165                 170                 175     


Leu Ala Lys Ala Ile Val Asp Glu Tyr Val Tyr Lys Tyr Asn Leu Asp 
            180                 185                 190         


Gly Leu Asp Val Asp Val Glu His Asp Ser Ile Pro Lys Val Asp Lys 
        195                 200                 205             


Lys Glu Asp Thr Ala Gly Val Glu Arg Ser Ile Gln Val Phe Glu Glu 
    210                 215                 220                 


Ile Gly Lys Leu Ile Gly Pro Lys Gly Val Asp Lys Ser Arg Leu Phe 
225                 230                 235                 240 


Ile Met Asp Ser Thr Tyr Met Ala Asp Lys Asn Pro Leu Ile Glu Arg 
                245                 250                 255     


Gly Ala Pro Tyr Ile Asn Leu Leu Leu Val Gln Val Tyr Gly Ser Gln 
            260                 265                 270         


Gly Glu Lys Gly Gly Trp Glu Pro Val Ser Asn Arg Pro Glu Lys Thr 
        275                 280                 285             


Met Glu Glu Arg Trp Gln Gly Tyr Ser Lys Tyr Ile Arg Pro Glu Gln 
    290                 295                 300                 


Tyr Met Ile Gly Phe Ser Phe Tyr Glu Glu Asn Ala Gln Glu Gly Asn 
305                 310                 315                 320 


Leu Trp Tyr Asp Ile Asn Ser Arg Lys Asp Glu Asp Lys Ala Asn Gly 
                325                 330                 335     


Ile Asn Thr Asp Ile Thr Gly Thr Arg Ala Glu Arg Tyr Ala Arg Trp 
            340                 345                 350         


Gln Pro Lys Thr Gly Gly Val Lys Gly Gly Ile Phe Ser Tyr Ala Ile 
        355                 360                 365             


Asp Arg Asp Gly Val Ala His Gln Pro Lys Lys Tyr Ala Lys Gln Lys 
    370                 375                 380                 


Glu Phe Lys Asp Ala Thr Asp Asn Ile Phe His Ser Asp Tyr Ser Val 
385                 390                 395                 400 


Ser Lys Ala Leu Lys Thr Val Met Leu Lys Asp Lys Ser Tyr Asp Leu 
                405                 410                 415     


Ile Asp Glu Lys Asp Phe Pro Asp Lys Ala Leu Arg Glu Ala Val Met 
            420                 425                 430         


Ala Gln Val Gly Thr Arg Lys Gly Asp Leu Glu Arg Phe Asn Gly Thr 
        435                 440                 445             


Leu Arg Leu Asp Asn Pro Ala Ile Gln Ser Leu Glu Gly Leu Asn Lys 
    450                 455                 460                 


Phe Lys Lys Leu Ala Gln Leu Asp Leu Ile Gly Leu Ser Arg Ile Thr 
465                 470                 475                 480 


Lys Leu Asp Arg Ser Val Leu Pro Ala Asn Met Lys Pro Gly Lys Asp 
                485                 490                 495     


Thr Leu Glu Thr Val Leu Glu Thr Tyr Lys Lys Asp Asn Lys Glu Glu 
            500                 505                 510         


Pro Ala Thr Ile Pro Pro Val Ser Leu Lys Val Ser Gly Leu Thr Gly 
        515                 520                 525             


Leu Lys Glu Leu Asp Leu Ser Gly Phe Asp Arg Glu Thr Leu Ala Gly 
    530                 535                 540                 


Leu Asp Ala Ala Thr Leu Thr Ser Leu Glu Lys Val Asp Ile Ser Gly 
545                 550                 555                 560 


Asn Lys Leu Asp Leu Ala Pro Gly Thr Glu Asn Arg Gln Ile Phe Asp 
                565                 570                 575     


Thr Met Leu Ser Thr Ile Ser Asn His Val Gly Ser Asn Glu Gln Thr 
            580                 585                 590         


Val Lys Phe Asp Lys Gln Lys Pro Thr Gly His Tyr Pro Asp Thr Tyr 
        595                 600                 605             


Gly Lys Thr Ser Leu Arg Leu Pro Val Ala Asn Glu Lys Val Asp Leu 
    610                 615                 620                 


Gln Ser Gln Leu Leu Phe Gly Thr Val Thr Asn Gln Gly Thr Leu Ile 
625                 630                 635                 640 


Asn Ser Glu Ala Asp Tyr Lys Ala Tyr Gln Asn His Lys Ile Ala Gly 
                645                 650                 655     


Arg Ser Phe Val Asp Ser Asn Tyr His Tyr Asn Asn Phe Lys Val Ser 
            660                 665                 670         


Tyr Glu Asn Tyr Thr Val Lys Val Thr Asp Ser Thr Leu Gly Thr Thr 
        675                 680                 685             


Thr Asp Lys Thr Leu Ala Thr Asp Lys Glu Glu Thr Tyr Lys Val Asp 
    690                 695                 700                 


Phe Phe Ser Pro Ala Asp Lys Thr Lys Ala Val His Thr Ala Lys Val 
705                 710                 715                 720 


Ile Val Gly Asp Glu Lys Thr Met Met Val Asn Leu Ala Glu Gly Ala 
                725                 730                 735     


Thr Val Ile Gly Gly Ser Ala Asp Pro Val Asn Ala Arg Lys Val Phe 
            740                 745                 750         


Asp Gly Gln Leu Gly Ser Glu Thr Asp Asn Ile Ser Leu Gly Trp Asp 
        755                 760                 765             


Ser Lys Gln Ser Ile Ile Phe Lys Leu Lys Glu Asp Gly Leu Ile Lys 
    770                 775                 780                 


His Trp Arg Phe Phe Asn Asp Ser Ala Arg Asn Pro Glu Thr Thr Asn 
785                 790                 795                 800 


Lys Pro Ile Gln Glu Ala Ser Leu Gln Ile Phe Asn Ile Lys Asp Tyr 
                805                 810                 815     


Asn Leu Asp Asn Leu Leu Glu Asn Pro Asn Lys Phe Asp Asp Glu Lys 
            820                 825                 830         


Tyr Trp Ile Thr Val Asp Thr Tyr Ser Ala Gln Gly Glu Arg Ala Thr 
        835                 840                 845             


Ala Phe Ser Asn Thr Leu Asn Asn Ile Thr Ser Lys Tyr Trp Arg Val 
    850                 855                 860                 


Val Phe Asp Thr Lys Gly Asp Arg Tyr Ser Ser Pro Val Val Pro Glu 
865                 870                 875                 880 


Leu Gln Ile Leu Gly Tyr Pro Leu Pro Asn Ala Asp Thr Ile Met Lys 
                885                 890                 895     


Thr Val Thr Thr Ala Lys Glu Leu Ser Gln Gln Lys Asp Lys Phe Ser 
            900                 905                 910         


Gln Lys Met Leu Asp Glu Leu Lys Ile Lys Glu Met Ala Leu Glu Thr 
        915                 920                 925             


Ser Leu Asn Ser Lys Ile Phe Asp Val Thr Ala Ile Asn Ala Asn Ala 
    930                 935                 940                 


Gly Val Leu Lys Asp Cys Ile Glu Lys Arg Gln Leu Leu Lys Lys 
945                 950                 955                 


