                         SEQUENCE LISTING

<110>  F. Hoffmann-La Roche AG
       Hoffmann-La Roche Inc.
       Genentech Inc.
 
<120>  NON-COVALENT PROTEIN-HYALURONAN CONJUGATES FOR LONG-ACTING OCULAR
        DELIVERY

<130>  P35668-WO

<150>  US 63/092251
<151>  2020-10-15

<150>  US 63/250782
<151>  2021-09-30

<160>  123   

<170>  PatentIn version 3.5

<210>  1
<211>  742
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu 
    210                 215                 220                 


Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu 
225                 230                 235                 240 


Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn 
                245                 250                 255     


His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr Ile 
            260                 265                 270         


Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg 
        275                 280                 285             


His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile 
    290                 295                 300                 


Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln 
305                 310                 315                 320 


Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val 
                325                 330                 335     


Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr 
            340                 345                 350         


Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile 
        355                 360                 365             


His His Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr 
    370                 375                 380                 


Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys 
385                 390                 395                 400 


Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro 
                405                 410                 415     


Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala His 
            420                 425                 430         


Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser 
        435                 440                 445             


Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly 
    450                 455                 460                 


His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Ile Thr 
465                 470                 475                 480 


Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp 
                485                 490                 495     


Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser 
            500                 505                 510         


Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr 
        515                 520                 525             


Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg 
    530                 535                 540                 


Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr 
545                 550                 555                 560 


Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val 
                565                 570                 575     


Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly 
            580                 585                 590         


Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr 
        595                 600                 605             


Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp 
    610                 615                 620                 


Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly 
625                 630                 635                 640 


Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser 
                645                 650                 655     


Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser 
            660                 665                 670         


Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn 
        675                 680                 685             


Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser 
    690                 695                 700                 


Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr 
705                 710                 715                 720 


Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val 
                725                 730                 735     


Asp Met Lys Ile Gly Val 
            740         


<210>  2
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD44 HA binding-domain sequence used in Fab-HABDs

<400>  2

Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly Val Phe His 
1               5                   10                  15      


Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu Ala Ala Asp 
            20                  25                  30          


Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala Gln Met Glu 
        35                  40                  45              


Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly Phe Ile Glu 
    50                  55                  60                  


Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile Cys Ala Ala 
65                  70                  75                  80  


Asn Asn Thr Gly Val Tyr Ile Leu Thr Tyr Asn Thr Ser Gln Tyr Asp 
                85                  90                  95      


Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp Cys Thr Ser 
            100                 105                 110         


Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr Ile Thr Ile 
        115                 120                 125             


Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu Tyr Arg Thr 
    130                 135                 140                 


Asn Pro Glu Asp Ile Tyr 
145                 150 


<210>  3
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNFAIP6; full-length TSG-6

<400>  3

Met Ile Ile Leu Ile Tyr Leu Phe Leu Leu Leu Trp Glu Asp Thr Gln 
1               5                   10                  15      


Gly Trp Gly Phe Lys Asp Gly Ile Phe His Asn Ser Ile Trp Leu Glu 
            20                  25                  30          


Arg Ala Ala Gly Val Tyr His Arg Glu Ala Arg Ser Gly Lys Tyr Lys 
        35                  40                  45              


Leu Thr Tyr Ala Glu Ala Lys Ala Val Cys Glu Phe Glu Gly Gly His 
    50                  55                  60                  


Leu Ala Thr Tyr Lys Gln Leu Glu Ala Ala Arg Lys Ile Gly Phe His 
65                  70                  75                  80  


Val Cys Ala Ala Gly Trp Met Ala Lys Gly Arg Val Gly Tyr Pro Ile 
                85                  90                  95      


Val Lys Pro Gly Pro Asn Cys Gly Phe Gly Lys Thr Gly Ile Ile Asp 
            100                 105                 110         


Tyr Gly Ile Arg Leu Asn Arg Ser Glu Arg Trp Asp Ala Tyr Cys Tyr 
        115                 120                 125             


Asn Pro His Ala Lys Glu Cys Gly Gly Val Phe Thr Asp Pro Lys Gln 
    130                 135                 140                 


Ile Phe Lys Ser Pro Gly Phe Pro Asn Glu Tyr Glu Asp Asn Gln Ile 
145                 150                 155                 160 


Cys Tyr Trp His Ile Arg Leu Lys Tyr Gly Gln Arg Ile His Leu Ser 
                165                 170                 175     


Phe Leu Asp Phe Asp Leu Glu Asp Asp Pro Gly Cys Leu Ala Asp Tyr 
            180                 185                 190         


Val Glu Ile Tyr Asp Ser Tyr Asp Asp Val His Gly Phe Val Gly Arg 
        195                 200                 205             


Tyr Cys Gly Asp Glu Leu Pro Asp Asp Ile Ile Ser Thr Gly Asn Val 
    210                 215                 220                 


Met Thr Leu Lys Phe Leu Ser Asp Ala Ser Val Thr Ala Gly Gly Phe 
225                 230                 235                 240 


Gln Ile Lys Tyr Val Ala Met Asp Pro Val Ser Lys Ser Ser Gln Gly 
                245                 250                 255     


Lys Asn Thr Ser Thr Thr Ser Thr Gly Asn Lys Asn Phe Leu Ala Gly 
            260                 265                 270         


Arg Phe Ser His Leu 
        275         


<210>  4
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSG-6 link domain (TSG6; 36-133)

<400>  4

Gly Val Tyr His Arg Glu Ala Arg Ser Gly Lys Tyr Lys Leu Thr Tyr 
1               5                   10                  15      


Ala Glu Ala Lys Ala Val Cys Glu Phe Glu Gly Gly His Leu Ala Thr 
            20                  25                  30          


Tyr Lys Gln Leu Glu Ala Ala Arg Lys Ile Gly Phe His Val Cys Ala 
        35                  40                  45              


Ala Gly Trp Met Ala Lys Gly Arg Val Gly Tyr Pro Ile Val Lys Pro 
    50                  55                  60                  


Gly Pro Asn Cys Gly Phe Gly Lys Thr Gly Ile Ile Asp Tyr Gly Ile 
65                  70                  75                  80  


Arg Leu Asn Arg Ser Glu Arg Trp Asp Ala Tyr Cys Tyr Asn Pro His 
                85                  90                  95      


Ala Lys His His His His His His 
            100                 


<210>  5
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VPDF-1xCD44 HC

<400>  5

Asp Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Asp Gly Trp Trp Phe Gly Tyr Thr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ser Ile Ser Tyr Lys Gly Gly Ser Thr Tyr Tyr Asn Thr Lys Phe 
    50                  55                  60                  


Ile Gly Arg Phe Thr Ile Ser Arg Asp Asp Asp Thr Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asp Gly Tyr Phe Asp Thr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Gly Gly Gly Gly Ser 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Ile Asp Leu Asn 
225                 230                 235                 240 


Ile Thr Cys Arg Phe Ala Gly Val Phe His Val Glu Lys Asn Gly Arg 
                245                 250                 255     


Tyr Ser Ile Ser Arg Thr Glu Ala Ala Asp Leu Cys Lys Ala Phe Asn 
            260                 265                 270         


Ser Thr Leu Pro Thr Met Ala Gln Met Glu Lys Ala Leu Ser Ile Gly 
        275                 280                 285             


Phe Glu Thr Cys Arg Tyr Gly Phe Ile Glu Gly His Val Val Ile Pro 
    290                 295                 300                 


Arg Ile His Pro Asn Ser Ile Cys Ala Ala Asn Asn Thr Gly Val Tyr 
305                 310                 315                 320 


Ile Leu Thr Tyr Asn Thr Ser Gln Tyr Asp Thr Tyr Cys Phe Asn Ala 
                325                 330                 335     


Ser Ala Pro Pro Glu Glu Asp Cys Thr Ser Val Thr Asp Leu Pro Asn 
            340                 345                 350         


Ala Phe Asp Gly Pro Ile Thr Ile Thr Ile Val Asn Arg Asp Gly Thr 
        355                 360                 365             


Arg Tyr Val Gln Lys Gly Glu Tyr Arg Thr Asn Pro Glu Asp Ile Tyr 
    370                 375                 380                 


<210>  6
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VPDF-1xCD44 LC

<400>  6

Ala Ile Tyr Met His Gln Glu Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Gly Ser Tyr Trp Leu Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Gly Lys Glu Arg Glu His Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser His Glu Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Arg Tyr His Pro Tyr 
                85                  90                  95      


Thr Phe Gly His Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu 
    210             


<210>  7
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VPDF-2xCD44 HC

<400>  7

Asp Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Asp Gly Trp Trp Phe Gly Tyr Thr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ser Ile Ser Tyr Lys Gly Gly Ser Thr Tyr Tyr Asn Thr Lys Phe 
    50                  55                  60                  


Ile Gly Arg Phe Thr Ile Ser Arg Asp Asp Asp Thr Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asp Gly Tyr Phe Asp Thr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Gly Gly Gly Gly Ser 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Ile Asp Leu Asn 
225                 230                 235                 240 


Ile Thr Cys Arg Phe Ala Gly Val Phe His Val Glu Lys Asn Gly Arg 
                245                 250                 255     


Tyr Ser Ile Ser Arg Thr Glu Ala Ala Asp Leu Cys Lys Ala Phe Asn 
            260                 265                 270         


Ser Thr Leu Pro Thr Met Ala Gln Met Glu Lys Ala Leu Ser Ile Gly 
        275                 280                 285             


Phe Glu Thr Cys Arg Tyr Gly Phe Ile Glu Gly His Val Val Ile Pro 
    290                 295                 300                 


Arg Ile His Pro Asn Ser Ile Cys Ala Ala Asn Asn Thr Gly Val Tyr 
305                 310                 315                 320 


Ile Leu Thr Tyr Asn Thr Ser Gln Tyr Asp Thr Tyr Cys Phe Asn Ala 
                325                 330                 335     


Ser Ala Pro Pro Glu Glu Asp Cys Thr Ser Val Thr Asp Leu Pro Asn 
            340                 345                 350         


Ala Phe Asp Gly Pro Ile Thr Ile Thr Ile Val Asn Arg Asp Gly Thr 
        355                 360                 365             


Arg Tyr Val Gln Lys Gly Glu Tyr Arg Thr Asn Pro Glu Asp Ile Tyr 
    370                 375                 380                 


<210>  8
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VPDF-2xCD44 LC

<400>  8

Ala Ile Tyr Met His Gln Glu Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Gly Ser Tyr Trp Leu Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Gly Lys Glu Arg Glu His Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser His Glu Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Arg Tyr His Pro Tyr 
                85                  90                  95      


Thr Phe Gly His Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 


Gly Gly Gly Gly Ser Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe 
225                 230                 235                 240 


Ala Gly Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg 
                245                 250                 255     


Thr Glu Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr 
            260                 265                 270         


Met Ala Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg 
        275                 280                 285             


Tyr Gly Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn 
    290                 295                 300                 


Ser Ile Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Tyr Asn 
305                 310                 315                 320 


Thr Ser Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu 
                325                 330                 335     


Glu Asp Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro 
            340                 345                 350         


Ile Thr Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys 
        355                 360                 365             


Gly Glu Tyr Arg Thr Asn Pro Glu Asp Ile Tyr 
    370                 375                 


<210>  9
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dig-1xCD44 HC

<400>  9

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Ile Gly Ala Thr Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Ser Pro Tyr Glu Tyr Asp Lys Ala Tyr Tyr Ser Met 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
                245                 250                 255     


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
            260                 265                 270         


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
        275                 280                 285             


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
    290                 295                 300                 


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
305                 310                 315                 320 


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Tyr Asn Thr Ser 
                325                 330                 335     


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
            340                 345                 350         


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
        355                 360                 365             


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
    370                 375                 380                 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr 
385                 390             


<210>  10
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dig-1xCD44 LC

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Lys Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ser Ser Thr Leu Leu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Ile Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  11
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dig-2xCD44 HC

<400>  11

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Ile Gly Ala Thr Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Ser Pro Tyr Glu Tyr Asp Lys Ala Tyr Tyr Ser Met 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
                245                 250                 255     


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
            260                 265                 270         


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
        275                 280                 285             


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
    290                 295                 300                 


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
305                 310                 315                 320 


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Tyr Asn Thr Ser 
                325                 330                 335     


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
            340                 345                 350         


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
        355                 360                 365             


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
    370                 375                 380                 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr 
385                 390             


<210>  12
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dig-2xCD44 LC

<400>  12

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Lys Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ser Ser Thr Leu Leu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Ile Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 


Gly Gly Gly Gly Ser Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe 
225                 230                 235                 240 


Ala Gly Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg 
                245                 250                 255     


Thr Glu Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr 
            260                 265                 270         


Met Ala Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg 
        275                 280                 285             


Tyr Gly Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn 
    290                 295                 300                 


Ser Ile Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Tyr Asn 
305                 310                 315                 320 


Thr Ser Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu 
                325                 330                 335     


Glu Asp Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro 
            340                 345                 350         


Ile Thr Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys 
        355                 360                 365             


Gly Glu Tyr Arg Thr Asn Pro Glu Asp Ile Tyr 
    370                 375                 


<210>  13
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RabFab-1xTSG6 HC

<400>  13

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Thr Ile Ser Ser Tyr His 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Met Arg Asn Thr Ala Asn Ile Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Pro Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Arg Pro Gly Asp Gly Ala Leu Ser Leu Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gln Pro Lys Ala Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Cys Gly Asp Thr Pro Ser Ser Thr Val Thr Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Gly Tyr Leu Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly 
145                 150                 155                 160 


Thr Leu Thr Asn Gly Val Arg Thr Phe Pro Ser Val Arg Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Ser Val Thr Ser Ser Ser Gln 
            180                 185                 190         


Pro Val Thr Cys Asn Val Ala His Pro Ala Thr Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Thr Val Ala Pro Ser Thr Cys Ser Lys Pro Thr Gly Gly Gly Gly 
    210                 215                 220                 


Ser Gly Val Tyr His Arg Glu Ala Arg Ser Gly Lys Tyr Lys Leu Thr 
225                 230                 235                 240 


Tyr Ala Glu Ala Lys Ala Val Cys Glu Phe Glu Gly Gly His Leu Ala 
                245                 250                 255     


Thr Tyr Lys Gln Leu Glu Ala Ala Arg Lys Ile Gly Phe His Val Cys 
            260                 265                 270         


Ala Ala Gly Trp Met Ala Lys Gly Arg Val Gly Tyr Pro Ile Val Lys 
        275                 280                 285             


Pro Gly Pro Asn Cys Gly Phe Gly Lys Thr Gly Ile Ile Asp Tyr Gly 
    290                 295                 300                 


Ile Arg Leu Asn Arg Ser Glu Arg Trp Asp Ala Tyr Cys Tyr Asn Pro 
305                 310                 315                 320 


His Ala Lys His His His His His His 
                325                 


<210>  14
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RabFab-1xTSG6 LC

<400>  14

Ala Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Ala Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Gly Thr 
            20                  25                  30          


Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Ala Tyr Val Ser Gly 
                85                  90                  95      


Gly Asn Ile Tyr Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys Gly 
            100                 105                 110         


Asp Pro Val Ala Pro Thr Val Leu Ile Phe Pro Pro Ala Ala Asp Gln 
        115                 120                 125             


Val Ala Thr Gly Thr Val Thr Ile Val Cys Val Ala Asn Lys Tyr Phe 
    130                 135                 140                 


Pro Asp Val Thr Val Thr Trp Glu Val Asp Gly Thr Thr Gln Thr Thr 
145                 150                 155                 160 


Gly Ile Glu Asn Ser Lys Thr Pro Gln Asn Ser Ala Asp Cys Thr Tyr 
                165                 170                 175     


Asn Leu Ser Ser Thr Leu Thr Leu Thr Ser Thr Gln Tyr Asn Gly His 
            180                 185                 190         


Lys Glu Tyr Thr Cys Lys Val Thr Gln Gly Thr Thr Ser Val Val Gln 
        195                 200                 205             


Ser Phe Asn Arg Gly Asp Cys 
    210                 215 


<210>  15
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RabFab-2xTSG6 HC

<400>  15

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Thr Ile Ser Ser Tyr His 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Met Arg Asn Thr Ala Asn Ile Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Pro Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Arg Pro Gly Asp Gly Ala Leu Ser Leu Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gln Pro Lys Ala Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Cys Gly Asp Thr Pro Ser Ser Thr Val Thr Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Gly Tyr Leu Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly 
145                 150                 155                 160 


Thr Leu Thr Asn Gly Val Arg Thr Phe Pro Ser Val Arg Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Ser Val Thr Ser Ser Ser Gln 
            180                 185                 190         


Pro Val Thr Cys Asn Val Ala His Pro Ala Thr Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Thr Val Ala Pro Ser Thr Cys Ser Lys Pro Thr Gly Gly Gly Gly 
    210                 215                 220                 


Ser Gly Val Tyr His Arg Glu Ala Arg Ser Gly Lys Tyr Lys Leu Thr 
225                 230                 235                 240 


Tyr Ala Glu Ala Lys Ala Val Cys Glu Phe Glu Gly Gly His Leu Ala 
                245                 250                 255     


Thr Tyr Lys Gln Leu Glu Ala Ala Arg Lys Ile Gly Phe His Val Cys 
            260                 265                 270         


Ala Ala Gly Trp Met Ala Lys Gly Arg Val Gly Tyr Pro Ile Val Lys 
        275                 280                 285             


Pro Gly Pro Asn Cys Gly Phe Gly Lys Thr Gly Ile Ile Asp Tyr Gly 
    290                 295                 300                 


Ile Arg Leu Asn Arg Ser Glu Arg Trp Asp Ala Tyr Cys Tyr Asn Pro 
305                 310                 315                 320 


His Ala Lys His His His His His His 
                325                 


<210>  16
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RabFab-2xTSG6 LC

<400>  16

Ala Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Ala Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Gly Thr 
            20                  25                  30          


Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Ala Tyr Val Ser Gly 
                85                  90                  95      


Gly Asn Ile Tyr Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys Gly 
            100                 105                 110         


Asp Pro Val Ala Pro Thr Val Leu Ile Phe Pro Pro Ala Ala Asp Gln 
        115                 120                 125             


Val Ala Thr Gly Thr Val Thr Ile Val Cys Val Ala Asn Lys Tyr Phe 
    130                 135                 140                 


Pro Asp Val Thr Val Thr Trp Glu Val Asp Gly Thr Thr Gln Thr Thr 
145                 150                 155                 160 


Gly Ile Glu Asn Ser Lys Thr Pro Gln Asn Ser Ala Asp Cys Thr Tyr 
                165                 170                 175     


Asn Leu Ser Ser Thr Leu Thr Leu Thr Ser Thr Gln Tyr Asn Gly His 
            180                 185                 190         


Lys Glu Tyr Thr Cys Lys Val Thr Gln Gly Thr Thr Ser Val Val Gln 
        195                 200                 205             


Ser Phe Asn Arg Gly Asp Cys Gly Gly Gly Gly Ser Gly Val Tyr His 
    210                 215                 220                 


Arg Glu Ala Arg Ser Gly Lys Tyr Lys Leu Thr Tyr Ala Glu Ala Lys 
225                 230                 235                 240 


Ala Val Cys Glu Phe Glu Gly Gly Arg Leu Ala Thr Tyr Lys Gln Leu 
                245                 250                 255     


Glu Ala Ala Arg Lys Ile Gly Phe His Val Cys Ala Ala Gly Trp Met 
            260                 265                 270         


Ala Lys Gly Arg Val Gly Tyr Pro Ile Val Lys Pro Gly Ser Asn Cys 
        275                 280                 285             


Gly Phe Gly Lys Thr Gly Ile Ile Asp Tyr Gly Ile Arg Leu Asn Arg 
    290                 295                 300                 


Ser Glu Arg Trp Asp Ala Tyr Cys Tyr Asn Pro His Ala Lys Asp Tyr 
305                 310                 315                 320 


Lys Asp Asp Asp Asp Lys 
                325     


<210>  17
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G6.31-1xTSG6 HC

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Asp Tyr 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Thr Pro Ala Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Val Phe Phe Leu Pro Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Gly Gly Gly Gly Ser Gly Val Tyr His Arg Glu Ala 
225                 230                 235                 240 


Arg Ser Gly Lys Tyr Lys Leu Thr Tyr Ala Glu Ala Lys Ala Val Cys 
                245                 250                 255     


Glu Phe Glu Gly Gly His Leu Ala Thr Tyr Lys Gln Leu Glu Ala Ala 
            260                 265                 270         


Arg Lys Ile Gly Phe His Val Cys Ala Ala Gly Trp Met Ala Lys Gly 
        275                 280                 285             


Arg Val Gly Tyr Pro Ile Val Lys Pro Gly Pro Asn Cys Gly Phe Gly 
    290                 295                 300                 


Lys Thr Gly Ile Ile Asp Tyr Gly Ile Arg Leu Asn Arg Ser Glu Arg 
305                 310                 315                 320 


Trp Asp Ala Tyr Cys Tyr Asn Pro His Ala Lys His His His His His 
                325                 330                 335     


His 
    


<210>  18
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G6.31-1xTSG6 LC

<400>  18

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Gly Asn Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  19
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G6.31-2xTSG6 HC

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Asp Tyr 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Thr Pro Ala Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Val Phe Phe Leu Pro Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Gly Gly Gly Gly Ser Gly Val Tyr His Arg Glu Ala 
225                 230                 235                 240 


Arg Ser Gly Lys Tyr Lys Leu Thr Tyr Ala Glu Ala Lys Ala Val Cys 
                245                 250                 255     


Glu Phe Glu Gly Gly His Leu Ala Thr Tyr Lys Gln Leu Glu Ala Ala 
            260                 265                 270         


Arg Lys Ile Gly Phe His Val Cys Ala Ala Gly Trp Met Ala Lys Gly 
        275                 280                 285             


Arg Val Gly Tyr Pro Ile Val Lys Pro Gly Pro Asn Cys Gly Phe Gly 
    290                 295                 300                 


Lys Thr Gly Ile Ile Asp Tyr Gly Ile Arg Leu Asn Arg Ser Glu Arg 
305                 310                 315                 320 


Trp Asp Ala Tyr Cys Tyr Asn Pro His Ala Lys His His His His His 
                325                 330                 335     


His 
    


<210>  20
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G6.31-2xTSG6 LC

<400>  20

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Gly Asn Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Val Tyr His Arg 
    210                 215                 220                 


Glu Ala Arg Ser Gly Lys Tyr Lys Leu Thr Tyr Ala Glu Ala Lys Ala 
225                 230                 235                 240 


Val Cys Glu Phe Glu Gly Gly His Leu Ala Thr Tyr Lys Gln Leu Glu 
                245                 250                 255     


Ala Ala Arg Lys Ile Gly Phe His Val Cys Ala Ala Gly Trp Met Ala 
            260                 265                 270         


Lys Gly Arg Val Gly Tyr Pro Ile Val Lys Pro Gly Pro Asn Cys Gly 
        275                 280                 285             


Phe Gly Lys Thr Gly Ile Ile Asp Tyr Gly Ile Arg Leu Asn Arg Ser 
    290                 295                 300                 


Glu Arg Trp Asp Ala Tyr Cys Tyr Asn Pro His Ala Lys Asp Tyr Lys 
305                 310                 315                 320 


Asp Asp Asp Asp Lys 
                325 


<210>  21
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NVS24-1xTSG6 (Lava12) HC

<400>  21

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Tyr Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Gly Phe Ile Asp Pro Gln Asn Asp Pro Tyr Tyr Ala Thr Trp Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Gly Asn His Asn Ser Gly Trp Gly Leu Asn Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Gly 
    210                 215                 220                 


Ser Gly Gly Gly Gly Val Tyr His Arg Glu Ala Ile Ser Gly Lys Tyr 
225                 230                 235                 240 


Tyr Leu Thr Tyr Ala Glu Ala Lys Ala Val Cys Glu Phe Glu Gly Gly 
                245                 250                 255     


His Leu Ala Thr Tyr Lys Gln Leu Leu Ala Ala Gln Lys Ile Gly Phe 
            260                 265                 270         


His Val Cys Ala Ala Gly Trp Met Ala Lys Gly Arg Val Gly Tyr Pro 
        275                 280                 285             


Ile Val Lys Pro Gly Pro Asn Cys Gly Phe Gly Lys Thr Gly Ile Ile 
    290                 295                 300                 


Asp Tyr Gly Ile Arg Leu Asn Arg Ser Glu Arg Trp Asp Ala Tyr Cys 
305                 310                 315                 320 


Tyr Asn Pro His Ala 
                325 


<210>  22
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NVS24-1xTSG6 (Lava12) LC

<400>  22

Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ile Ile Thr Cys Gln Ala Ser Gln Lys Ile His Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gln Ala Ser Lys Leu Ala Lys Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Tyr Leu Ala Ser Thr 
                85                  90                  95      


Asn Gly Ala Asn Phe Gly Gln Gly Thr Lys Leu Thr Val Leu Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  23
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VPDF-1xTSG6 (Lava12) HC

<400>  23

Asp Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Asp Gly Trp Trp Phe Gly Tyr Thr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ser Ile Ser Tyr Lys Gly Gly Ser Thr Tyr Tyr Asn Thr Lys Phe 
    50                  55                  60                  


Ile Gly Arg Phe Thr Ile Ser Arg Asp Asp Asp Thr Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asp Gly Tyr Phe Asp Thr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Val Tyr His Arg Glu Ala Ile Ser Gly Lys 
225                 230                 235                 240 


Tyr Tyr Leu Thr Tyr Ala Glu Ala Lys Ala Val Cys Glu Phe Glu Gly 
                245                 250                 255     


Gly His Leu Ala Thr Tyr Lys Gln Leu Leu Ala Ala Gln Lys Ile Gly 
            260                 265                 270         


Phe His Val Cys Ala Ala Gly Trp Met Ala Lys Gly Arg Val Gly Tyr 
        275                 280                 285             


Pro Ile Val Lys Pro Gly Pro Asn Cys Gly Phe Gly Lys Thr Gly Ile 
    290                 295                 300                 


Ile Asp Tyr Gly Ile Arg Leu Asn Arg Ser Glu Arg Trp Asp Ala Tyr 
305                 310                 315                 320 


Cys Tyr Asn Pro His Ala Lys 
                325         


<210>  24
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VPDF-1xTSG6 (Lava12) LC

<400>  24

Ala Ile Tyr Met His Gln Glu Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Gly Ser Tyr Trp Leu Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Gly Lys Glu Arg Glu His Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser His Glu Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Arg Tyr His Pro Tyr 
                85                  90                  95      


Thr Phe Gly His Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  25
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VPDF-2xCD44-knockout (ko) HC

<400>  25

Asp Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Asp Gly Trp Trp Phe Gly Tyr Thr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ser Ile Ser Tyr Lys Gly Gly Ser Thr Tyr Tyr Asn Thr Lys Phe 
    50                  55                  60                  


Ile Gly Arg Phe Thr Ile Ser Arg Asp Asp Asp Thr Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asp Gly Tyr Phe Asp Thr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Gly Gly Gly Gly Ser 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Ile Asp Leu Asn 
225                 230                 235                 240 


Ile Thr Cys Arg Phe Ala Gly Val Phe His Val Glu Lys Asn Gly Arg 
                245                 250                 255     


Ser Ser Ile Ser Arg Thr Glu Ala Ala Asp Leu Cys Lys Ala Phe Asn 
            260                 265                 270         


Ser Thr Leu Pro Thr Met Ala Gln Met Glu Lys Ala Leu Ser Ile Gly 
        275                 280                 285             


Phe Glu Thr Cys Arg Tyr Gly Phe Ile Glu Gly His Val Val Ile Pro 
    290                 295                 300                 


Arg Ile His Pro Asn Ser Ile Cys Ala Ala Asn Asn Thr Gly Val Tyr 
305                 310                 315                 320 


Ile Leu Thr Tyr Asn Thr Ser Gln Tyr Asp Thr Tyr Cys Phe Asn Ala 
                325                 330                 335     


Ser Ala Pro Pro Glu Glu Asp Cys Thr Ser Val Thr Asp Leu Pro Asn 
            340                 345                 350         


Ala Phe Asp Gly Pro Ile Thr Ile Thr Ile Val Asn Arg Asp Gly Thr 
        355                 360                 365             


Arg Tyr Val Gln Lys Gly Glu Tyr Arg Thr Asn Pro Glu Asp Ile Tyr 
    370                 375                 380                 


<210>  26
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VPDF-2xCD44-knockout (ko) LC

<400>  26

Ala Ile Tyr Met His Gln Glu Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Gly Ser Tyr Trp Leu Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Gly Lys Glu Arg Glu His Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser His Glu Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Arg Tyr His Pro Tyr 
                85                  90                  95      


Thr Phe Gly His Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 


Gly Gly Gly Gly Ser Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe 
225                 230                 235                 240 


Ala Gly Val Phe His Val Glu Lys Asn Gly Arg Ser Ser Ile Ser Arg 
                245                 250                 255     


Thr Glu Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr 
            260                 265                 270         


Met Ala Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg 
        275                 280                 285             


Tyr Gly Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn 
    290                 295                 300                 


Ser Ile Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Tyr Asn 
305                 310                 315                 320 


Thr Ser Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu 
                325                 330                 335     


Glu Asp Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro 
            340                 345                 350         


Ile Thr Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys 
        355                 360                 365             


Gly Glu Tyr Arg Thr Asn Pro Glu Asp Ile Tyr 
    370                 375                 


<210>  27
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker for RabFab-VG1, PigFab-VG1, G6.31.Fab-VG1, VPDF-VG1, 
       VPDF-VG1?Ig, 20D12v2.3-VG1

<400>  27

Gly Gly Gly Ser 
1               


<210>  28
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  28

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  29
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT VG1

<400>  29

Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val Arg Gly Ser Leu 
1               5                   10                  15      


Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr Met Pro Thr Leu 
            20                  25                  30          


Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile Lys Trp Ser Lys 
        35                  40                  45              


Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu Thr Thr Val Leu 
    50                  55                  60                  


Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp Tyr Lys Gly Arg 
65                  70                  75                  80  


Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp Ala Ser Leu Thr 
                85                  90                  95      


Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr Arg Cys Asp Val 
            100                 105                 110         


Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser Leu Thr Val Asp 
        115                 120                 125             


Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg Tyr Thr Leu Asn 
    130                 135                 140                 


Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly Ala Val Ile Ala 
145                 150                 155                 160 


Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly Phe Glu Gln Cys 
                165                 170                 175     


Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr Pro Ile Arg Ala 
            180                 185                 190         


Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys Ala Gly Val Arg 
        195                 200                 205             


Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp Val Tyr Cys Tyr 
    210                 215                 220                 


Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr Val Pro Ser Lys 
225                 230                 235                 240 


Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn Gln Asp Ala Arg 
                245                 250                 255     


Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg Asn Gly Phe Asp 
            260                 265                 270         


Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val Arg His Pro Val 
        275                 280                 285             


Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu Gly Val Arg Thr 
    290                 295                 300                 


Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro Pro Asp Ser Arg 
305                 310                 315                 320 


Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu Gly Asn Ser His His His 
                325                 330                 335     


His His His His His 
            340     


<210>  30
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VG Link1

<400>  30

Gly Ser Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg Tyr Thr 
1               5                   10                  15      


Leu Asn Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly Ala Val 
            20                  25                  30          


Ile Ala Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly Phe Glu 
        35                  40                  45              


Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr Pro Ile 
    50                  55                  60                  


Arg Ala Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys Ala Gly 
65                  70                  75                  80  


Val Arg Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp Val Tyr 
                85                  90                  95      


Cys Tyr Val Asp His His His His His His His His 
            100                 105             


<210>  31
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VG Link2

<400>  31

Gly Asp Val Phe His Leu Thr Val Pro Ser Lys Phe Thr Phe Glu Glu 
1               5                   10                  15      


Ala Ala Lys Glu Cys Glu Asn Gln Asp Ala Arg Leu Ala Thr Val Gly 
            20                  25                  30          


Glu Leu Gln Ala Ala Trp Arg Asn Gly Phe Asp Gln Cys Asp Tyr Gly 
        35                  40                  45              


Trp Leu Ser Asp Ala Ser Val Arg His Pro Val Thr Val Ala Arg Ala 
    50                  55                  60                  


Gln Cys Gly Gly Gly Leu Leu Gly Val Arg Thr Leu Tyr Arg Phe Glu 
65                  70                  75                  80  


Asn Gln Thr Gly Phe Pro Pro Pro Asp Ser Arg Phe Asp Ala Tyr Cys 
                85                  90                  95      


Phe Lys Pro Lys Glu Gly Asn Ser His His His His His His His His 
            100                 105                 110         


<210>  32
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VG1?Ig

<400>  32

Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg Tyr Thr Leu Asn Phe 
1               5                   10                  15      


Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly Ala Val Ile Ala Thr 
            20                  25                  30          


Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly Phe Glu Gln Cys Asp 
        35                  40                  45              


Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr Pro Ile Arg Ala Pro 
    50                  55                  60                  


Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys Ala Gly Val Arg Thr 
65                  70                  75                  80  


Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp Val Tyr Cys Tyr Val 
                85                  90                  95      


Asp His Leu Asp Gly Asp Val Phe His Leu Thr Val Pro Ser Lys Phe 
            100                 105                 110         


Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn Gln Asp Ala Arg Leu 
        115                 120                 125             


Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg Asn Gly Phe Asp Gln 
    130                 135                 140                 


Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val Arg His Pro Val Thr 
145                 150                 155                 160 


Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu Gly Val Arg Thr Leu 
                165                 170                 175     


Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro Pro Asp Ser Arg Phe 
            180                 185                 190         


Asp Ala Tyr Cys Phe Lys Pro Lys Glu Gly Asn Ser His His His His 
        195                 200                 205             


His His His His 
    210         


<210>  33
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R160A

<400>  33

Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val Arg Gly Ser Leu 
1               5                   10                  15      


Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr Met Pro Thr Leu 
            20                  25                  30          


Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile Lys Trp Ser Lys 
        35                  40                  45              


Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu Thr Thr Val Leu 
    50                  55                  60                  


Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp Tyr Lys Gly Arg 
65                  70                  75                  80  


Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp Ala Ser Leu Thr 
                85                  90                  95      


Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr Arg Cys Asp Val 
            100                 105                 110         


Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser Leu Thr Val Asp 
        115                 120                 125             


Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Ala Tyr Thr Leu Asn 
    130                 135                 140                 


Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly Ala Val Ile Ala 
145                 150                 155                 160 


Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly Phe Glu Gln Cys 
                165                 170                 175     


Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr Pro Ile Arg Ala 
            180                 185                 190         


Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys Ala Gly Val Arg 
        195                 200                 205             


Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp Val Tyr Cys Tyr 
    210                 215                 220                 


Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr Val Pro Ser Lys 
225                 230                 235                 240 


Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn Gln Asp Ala Arg 
                245                 250                 255     


Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg Asn Gly Phe Asp 
            260                 265                 270         


Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val Arg His Pro Val 
        275                 280                 285             


Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu Gly Val Arg Thr 
    290                 295                 300                 


Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro Pro Asp Ser Arg 
305                 310                 315                 320 


Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu Gly Asn Ser His His His 
                325                 330                 335     


His His His His His 
            340     


<210>  34
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Y161A

<400>  34

Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val Arg Gly Ser Leu 
1               5                   10                  15      


Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr Met Pro Thr Leu 
            20                  25                  30          


Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile Lys Trp Ser Lys 
        35                  40                  45              


Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu Thr Thr Val Leu 
    50                  55                  60                  


Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp Tyr Lys Gly Arg 
65                  70                  75                  80  


Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp Ala Ser Leu Thr 
                85                  90                  95      


Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr Arg Cys Asp Val 
            100                 105                 110         


Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser Leu Thr Val Asp 
        115                 120                 125             


Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg Ala Thr Leu Asn 
    130                 135                 140                 


Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly Ala Val Ile Ala 
145                 150                 155                 160 


Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly Phe Glu Gln Cys 
                165                 170                 175     


Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr Pro Ile Arg Ala 
            180                 185                 190         


Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys Ala Gly Val Arg 
        195                 200                 205             


Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp Val Tyr Cys Tyr 
    210                 215                 220                 


Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr Val Pro Ser Lys 
225                 230                 235                 240 


Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn Gln Asp Ala Arg 
                245                 250                 255     


Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg Asn Gly Phe Asp 
            260                 265                 270         


Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val Arg His Pro Val 
        275                 280                 285             


Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu Gly Val Arg Thr 
    290                 295                 300                 


Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro Pro Asp Ser Arg 
305                 310                 315                 320 


Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu Gly Asn Ser His His His 
                325                 330                 335     


His His His His His 
            340     


<210>  35
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E194A

<400>  35

Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val Arg Gly Ser Leu 
1               5                   10                  15      


Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr Met Pro Thr Leu 
            20                  25                  30          


Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile Lys Trp Ser Lys 
        35                  40                  45              


Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu Thr Thr Val Leu 
    50                  55                  60                  


Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp Tyr Lys Gly Arg 
65                  70                  75                  80  


Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp Ala Ser Leu Thr 
                85                  90                  95      


Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr Arg Cys Asp Val 
            100                 105                 110         


Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser Leu Thr Val Asp 
        115                 120                 125             


Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg Tyr Thr Leu Asn 
    130                 135                 140                 


Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly Ala Val Ile Ala 
145                 150                 155                 160 


Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly Phe Ala Gln Cys 
                165                 170                 175     


Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr Pro Ile Arg Ala 
            180                 185                 190         


Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys Ala Gly Val Arg 
        195                 200                 205             


Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp Val Tyr Cys Tyr 
    210                 215                 220                 


Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr Val Pro Ser Lys 
225                 230                 235                 240 


Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn Gln Asp Ala Arg 
                245                 250                 255     


Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg Asn Gly Phe Asp 
            260                 265                 270         


Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val Arg His Pro Val 
        275                 280                 285             


Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu Gly Val Arg Thr 
    290                 295                 300                 


Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro Pro Asp Ser Arg 
305                 310                 315                 320 


Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu Gly Asn Ser His His His 
                325                 330                 335     


His His His His His 
            340     


<210>  36
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D197A

<400>  36

Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val Arg Gly Ser Leu 
1               5                   10                  15      


Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr Met Pro Thr Leu 
            20                  25                  30          


Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile Lys Trp Ser Lys 
        35                  40                  45              


Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu Thr Thr Val Leu 
    50                  55                  60                  


Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp Tyr Lys Gly Arg 
65                  70                  75                  80  


Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp Ala Ser Leu Thr 
                85                  90                  95      


Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr Arg Cys Asp Val 
            100                 105                 110         


Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser Leu Thr Val Asp 
        115                 120                 125             


Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg Tyr Thr Leu Asn 
    130                 135                 140                 


Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly Ala Val Ile Ala 
145                 150                 155                 160 


Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly Phe Glu Gln Cys 
                165                 170                 175     


Ala Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr Pro Ile Arg Ala 
            180                 185                 190         


Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys Ala Gly Val Arg 
        195                 200                 205             


Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp Val Tyr Cys Tyr 
    210                 215                 220                 


Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr Val Pro Ser Lys 
225                 230                 235                 240 


Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn Gln Asp Ala Arg 
                245                 250                 255     


Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg Asn Gly Phe Asp 
            260                 265                 270         


Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val Arg His Pro Val 
        275                 280                 285             


Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu Gly Val Arg Thr 
    290                 295                 300                 


Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro Pro Asp Ser Arg 
305                 310                 315                 320 


Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu Gly Asn Ser His His His 
                325                 330                 335     


His His His His His 
            340     


<210>  37
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D197S

<400>  37

Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val Arg Gly Ser Leu 
1               5                   10                  15      


Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr Met Pro Thr Leu 
            20                  25                  30          


Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile Lys Trp Ser Lys 
        35                  40                  45              


Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu Thr Thr Val Leu 
    50                  55                  60                  


Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp Tyr Lys Gly Arg 
65                  70                  75                  80  


Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp Ala Ser Leu Thr 
                85                  90                  95      


Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr Arg Cys Asp Val 
            100                 105                 110         


Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser Leu Thr Val Asp 
        115                 120                 125             


Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg Tyr Thr Leu Asn 
    130                 135                 140                 


Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly Ala Val Ile Ala 
145                 150                 155                 160 


Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly Phe Glu Gln Cys 
                165                 170                 175     


Ser Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr Pro Ile Arg Ala 
            180                 185                 190         


Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys Ala Gly Val Arg 
        195                 200                 205             


Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp Val Tyr Cys Tyr 
    210                 215                 220                 


Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr Val Pro Ser Lys 
225                 230                 235                 240 


Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn Gln Asp Ala Arg 
                245                 250                 255     


Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg Asn Gly Phe Asp 
            260                 265                 270         


Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val Arg His Pro Val 
        275                 280                 285             


Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu Gly Val Arg Thr 
    290                 295                 300                 


Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro Pro Asp Ser Arg 
305                 310                 315                 320 


Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu Gly Asn Ser His His His 
                325                 330                 335     


His His His His His 
            340     


<210>  38
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Y208A

<400>  38

Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val Arg Gly Ser Leu 
1               5                   10                  15      


Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr Met Pro Thr Leu 
            20                  25                  30          


Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile Lys Trp Ser Lys 
        35                  40                  45              


Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu Thr Thr Val Leu 
    50                  55                  60                  


Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp Tyr Lys Gly Arg 
65                  70                  75                  80  


Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp Ala Ser Leu Thr 
                85                  90                  95      


Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr Arg Cys Asp Val 
            100                 105                 110         


Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser Leu Thr Val Asp 
        115                 120                 125             


Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg Tyr Thr Leu Asn 
    130                 135                 140                 


Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly Ala Val Ile Ala 
145                 150                 155                 160 


Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly Phe Glu Gln Cys 
                165                 170                 175     


Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Ala Pro Ile Arg Ala 
            180                 185                 190         


Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys Ala Gly Val Arg 
        195                 200                 205             


Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp Val Tyr Cys Tyr 
    210                 215                 220                 


Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr Val Pro Ser Lys 
225                 230                 235                 240 


Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn Gln Asp Ala Arg 
                245                 250                 255     


Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg Asn Gly Phe Asp 
            260                 265                 270         


Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val Arg His Pro Val 
        275                 280                 285             


Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu Gly Val Arg Thr 
    290                 295                 300                 


Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro Pro Asp Ser Arg 
305                 310                 315                 320 


Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu Gly Asn Ser His His His 
                325                 330                 335     


His His His His His 
            340     


<210>  39
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Y208F

<400>  39

Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val Arg Gly Ser Leu 
1               5                   10                  15      


Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr Met Pro Thr Leu 
            20                  25                  30          


Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile Lys Trp Ser Lys 
        35                  40                  45              


Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu Thr Thr Val Leu 
    50                  55                  60                  


Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp Tyr Lys Gly Arg 
65                  70                  75                  80  


Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp Ala Ser Leu Thr 
                85                  90                  95      


Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr Arg Cys Asp Val 
            100                 105                 110         


Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser Leu Thr Val Asp 
        115                 120                 125             


Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg Tyr Thr Leu Asn 
    130                 135                 140                 


Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly Ala Val Ile Ala 
145                 150                 155                 160 


Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly Phe Glu Gln Cys 
                165                 170                 175     


Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Phe Pro Ile Arg Ala 
            180                 185                 190         


Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys Ala Gly Val Arg 
        195                 200                 205             


Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp Val Tyr Cys Tyr 
    210                 215                 220                 


Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr Val Pro Ser Lys 
225                 230                 235                 240 


Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn Gln Asp Ala Arg 
                245                 250                 255     


Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg Asn Gly Phe Asp 
            260                 265                 270         


Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val Arg His Pro Val 
        275                 280                 285             


Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu Gly Val Arg Thr 
    290                 295                 300                 


Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro Pro Asp Ser Arg 
305                 310                 315                 320 


Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu Gly Asn Ser His His His 
                325                 330                 335     


His His His His His 
            340     


<210>  40
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R214A

<400>  40

Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val Arg Gly Ser Leu 
1               5                   10                  15      


Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr Met Pro Thr Leu 
            20                  25                  30          


Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile Lys Trp Ser Lys 
        35                  40                  45              


Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu Thr Thr Val Leu 
    50                  55                  60                  


Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp Tyr Lys Gly Arg 
65                  70                  75                  80  


Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp Ala Ser Leu Thr 
                85                  90                  95      


Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr Arg Cys Asp Val 
            100                 105                 110         


Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser Leu Thr Val Asp 
        115                 120                 125             


Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg Tyr Thr Leu Asn 
    130                 135                 140                 


Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly Ala Val Ile Ala 
145                 150                 155                 160 


Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly Phe Glu Gln Cys 
                165                 170                 175     


Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr Pro Ile Arg Ala 
            180                 185                 190         


Pro Ala Val Gly Cys Tyr Gly Asp Lys Met Gly Lys Ala Gly Val Arg 
        195                 200                 205             


Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp Val Tyr Cys Tyr 
    210                 215                 220                 


Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr Val Pro Ser Lys 
225                 230                 235                 240 


Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn Gln Asp Ala Arg 
                245                 250                 255     


Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg Asn Gly Phe Asp 
            260                 265                 270         


Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val Arg His Pro Val 
        275                 280                 285             


Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu Gly Val Arg Thr 
    290                 295                 300                 


Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro Pro Asp Ser Arg 
305                 310                 315                 320 


Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu Gly Asn Ser His His His 
                325                 330                 335     


His His His His His 
            340     


<210>  41
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R214K

<400>  41

Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val Arg Gly Ser Leu 
1               5                   10                  15      


Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr Met Pro Thr Leu 
            20                  25                  30          


Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile Lys Trp Ser Lys 
        35                  40                  45              


Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu Thr Thr Val Leu 
    50                  55                  60                  


Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp Tyr Lys Gly Arg 
65                  70                  75                  80  


Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp Ala Ser Leu Thr 
                85                  90                  95      


Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr Arg Cys Asp Val 
            100                 105                 110         


Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser Leu Thr Val Asp 
        115                 120                 125             


Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg Tyr Thr Leu Asn 
    130                 135                 140                 


Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly Ala Val Ile Ala 
145                 150                 155                 160 


Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly Phe Glu Gln Cys 
                165                 170                 175     


Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr Pro Ile Arg Ala 
            180                 185                 190         


Pro Lys Val Gly Cys Tyr Gly Asp Lys Met Gly Lys Ala Gly Val Arg 
        195                 200                 205             


Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp Val Tyr Cys Tyr 
    210                 215                 220                 


Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr Val Pro Ser Lys 
225                 230                 235                 240 


Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn Gln Asp Ala Arg 
                245                 250                 255     


Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg Asn Gly Phe Asp 
            260                 265                 270         


Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val Arg His Pro Val 
        275                 280                 285             


Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu Gly Val Arg Thr 
    290                 295                 300                 


Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro Pro Asp Ser Arg 
305                 310                 315                 320 


Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu Gly Asn Ser His His His 
                325                 330                 335     


His His His His His 
            340     


<210>  42
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M222A

<400>  42

Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val Arg Gly Ser Leu 
1               5                   10                  15      


Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr Met Pro Thr Leu 
            20                  25                  30          


Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile Lys Trp Ser Lys 
        35                  40                  45              


Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu Thr Thr Val Leu 
    50                  55                  60                  


Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp Tyr Lys Gly Arg 
65                  70                  75                  80  


Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp Ala Ser Leu Thr 
                85                  90                  95      


Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr Arg Cys Asp Val 
            100                 105                 110         


Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser Leu Thr Val Asp 
        115                 120                 125             


Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg Tyr Thr Leu Asn 
    130                 135                 140                 


Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly Ala Val Ile Ala 
145                 150                 155                 160 


Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly Phe Glu Gln Cys 
                165                 170                 175     


Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr Pro Ile Arg Ala 
            180                 185                 190         


Pro Arg Val Gly Cys Tyr Gly Asp Lys Ala Gly Lys Ala Gly Val Arg 
        195                 200                 205             


Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp Val Tyr Cys Tyr 
    210                 215                 220                 


Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr Val Pro Ser Lys 
225                 230                 235                 240 


Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn Gln Asp Ala Arg 
                245                 250                 255     


Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg Asn Gly Phe Asp 
            260                 265                 270         


Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val Arg His Pro Val 
        275                 280                 285             


Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu Gly Val Arg Thr 
    290                 295                 300                 


Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro Pro Asp Ser Arg 
305                 310                 315                 320 


Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu Gly Asn Ser His His His 
                325                 330                 335     


His His His His His 
            340     


<210>  43
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Y230A

<400>  43

Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val Arg Gly Ser Leu 
1               5                   10                  15      


Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr Met Pro Thr Leu 
            20                  25                  30          


Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile Lys Trp Ser Lys 
        35                  40                  45              


Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu Thr Thr Val Leu 
    50                  55                  60                  


Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp Tyr Lys Gly Arg 
65                  70                  75                  80  


Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp Ala Ser Leu Thr 
                85                  90                  95      


Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr Arg Cys Asp Val 
            100                 105                 110         


Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser Leu Thr Val Asp 
        115                 120                 125             


Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg Tyr Thr Leu Asn 
    130                 135                 140                 


Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly Ala Val Ile Ala 
145                 150                 155                 160 


Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly Phe Glu Gln Cys 
                165                 170                 175     


Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr Pro Ile Arg Ala 
            180                 185                 190         


Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys Ala Gly Val Arg 
        195                 200                 205             


Thr Ala Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp Val Tyr Cys Tyr 
    210                 215                 220                 


Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr Val Pro Ser Lys 
225                 230                 235                 240 


Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn Gln Asp Ala Arg 
                245                 250                 255     


Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg Asn Gly Phe Asp 
            260                 265                 270         


Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val Arg His Pro Val 
        275                 280                 285             


Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu Gly Val Arg Thr 
    290                 295                 300                 


Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro Pro Asp Ser Arg 
305                 310                 315                 320 


Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu Gly Asn Ser His His His 
                325                 330                 335     


His His His His His 
            340     


<210>  44
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Y230F

<400>  44

Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val Arg Gly Ser Leu 
1               5                   10                  15      


Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr Met Pro Thr Leu 
            20                  25                  30          


Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile Lys Trp Ser Lys 
        35                  40                  45              


Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu Thr Thr Val Leu 
    50                  55                  60                  


Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp Tyr Lys Gly Arg 
65                  70                  75                  80  


Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp Ala Ser Leu Thr 
                85                  90                  95      


Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr Arg Cys Asp Val 
            100                 105                 110         


Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser Leu Thr Val Asp 
        115                 120                 125             


Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg Tyr Thr Leu Asn 
    130                 135                 140                 


Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly Ala Val Ile Ala 
145                 150                 155                 160 


Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly Phe Glu Gln Cys 
                165                 170                 175     


Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr Pro Ile Arg Ala 
            180                 185                 190         


Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys Ala Gly Val Arg 
        195                 200                 205             


Thr Phe Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp Val Tyr Cys Tyr 
    210                 215                 220                 


Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr Val Pro Ser Lys 
225                 230                 235                 240 


Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn Gln Asp Ala Arg 
                245                 250                 255     


Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg Asn Gly Phe Asp 
            260                 265                 270         


Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val Arg His Pro Val 
        275                 280                 285             


Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu Gly Val Arg Thr 
    290                 295                 300                 


Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro Pro Asp Ser Arg 
305                 310                 315                 320 


Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu Gly Asn Ser His His His 
                325                 330                 335     


His His His His His 
            340     


<210>  45
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R233A

<400>  45

Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val Arg Gly Ser Leu 
1               5                   10                  15      


Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr Met Pro Thr Leu 
            20                  25                  30          


Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile Lys Trp Ser Lys 
        35                  40                  45              


Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu Thr Thr Val Leu 
    50                  55                  60                  


Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp Tyr Lys Gly Arg 
65                  70                  75                  80  


Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp Ala Ser Leu Thr 
                85                  90                  95      


Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr Arg Cys Asp Val 
            100                 105                 110         


Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser Leu Thr Val Asp 
        115                 120                 125             


Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg Tyr Thr Leu Asn 
    130                 135                 140                 


Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly Ala Val Ile Ala 
145                 150                 155                 160 


Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly Phe Glu Gln Cys 
                165                 170                 175     


Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr Pro Ile Arg Ala 
            180                 185                 190         


Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys Ala Gly Val Arg 
        195                 200                 205             


Thr Tyr Gly Phe Ala Ser Pro Gln Glu Thr Tyr Asp Val Tyr Cys Tyr 
    210                 215                 220                 


Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr Val Pro Ser Lys 
225                 230                 235                 240 


Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn Gln Asp Ala Arg 
                245                 250                 255     


Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg Asn Gly Phe Asp 
            260                 265                 270         


Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val Arg His Pro Val 
        275                 280                 285             


Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu Gly Val Arg Thr 
    290                 295                 300                 


Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro Pro Asp Ser Arg 
305                 310                 315                 320 


Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu Gly Asn Ser His His His 
                325                 330                 335     


His His His His His 
            340     


<210>  46
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K260A

<400>  46

Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val Arg Gly Ser Leu 
1               5                   10                  15      


Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr Met Pro Thr Leu 
            20                  25                  30          


Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile Lys Trp Ser Lys 
        35                  40                  45              


Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu Thr Thr Val Leu 
    50                  55                  60                  


Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp Tyr Lys Gly Arg 
65                  70                  75                  80  


Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp Ala Ser Leu Thr 
                85                  90                  95      


Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr Arg Cys Asp Val 
            100                 105                 110         


Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser Leu Thr Val Asp 
        115                 120                 125             


Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg Tyr Thr Leu Asn 
    130                 135                 140                 


Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly Ala Val Ile Ala 
145                 150                 155                 160 


Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly Phe Glu Gln Cys 
                165                 170                 175     


Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr Pro Ile Arg Ala 
            180                 185                 190         


Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys Ala Gly Val Arg 
        195                 200                 205             


Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp Val Tyr Cys Tyr 
    210                 215                 220                 


Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr Val Pro Ser Ala 
225                 230                 235                 240 


Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn Gln Asp Ala Arg 
                245                 250                 255     


Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg Asn Gly Phe Asp 
            260                 265                 270         


Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val Arg His Pro Val 
        275                 280                 285             


Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu Gly Val Arg Thr 
    290                 295                 300                 


Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro Pro Asp Ser Arg 
305                 310                 315                 320 


Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu Gly Asn Ser His His His 
                325                 330                 335     


His His His His His 
            340     


<210>  47
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F261A

<400>  47

Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val Arg Gly Ser Leu 
1               5                   10                  15      


Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr Met Pro Thr Leu 
            20                  25                  30          


Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile Lys Trp Ser Lys 
        35                  40                  45              


Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu Thr Thr Val Leu 
    50                  55                  60                  


Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp Tyr Lys Gly Arg 
65                  70                  75                  80  


Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp Ala Ser Leu Thr 
                85                  90                  95      


Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr Arg Cys Asp Val 
            100                 105                 110         


Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser Leu Thr Val Asp 
        115                 120                 125             


Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg Tyr Thr Leu Asn 
    130                 135                 140                 


Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly Ala Val Ile Ala 
145                 150                 155                 160 


Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly Phe Glu Gln Cys 
                165                 170                 175     


Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr Pro Ile Arg Ala 
            180                 185                 190         


Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys Ala Gly Val Arg 
        195                 200                 205             


Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp Val Tyr Cys Tyr 
    210                 215                 220                 


Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr Val Pro Ser Lys 
225                 230                 235                 240 


Ala Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn Gln Asp Ala Arg 
                245                 250                 255     


Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg Asn Gly Phe Asp 
            260                 265                 270         


Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val Arg His Pro Val 
        275                 280                 285             


Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu Gly Val Arg Thr 
    290                 295                 300                 


Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro Pro Asp Ser Arg 
305                 310                 315                 320 


Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu Gly Asn Ser His His His 
                325                 330                 335     


His His His His His 
            340     


<210>  48
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D295A

<400>  48

Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val Arg Gly Ser Leu 
1               5                   10                  15      


Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr Met Pro Thr Leu 
            20                  25                  30          


Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile Lys Trp Ser Lys 
        35                  40                  45              


Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu Thr Thr Val Leu 
    50                  55                  60                  


Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp Tyr Lys Gly Arg 
65                  70                  75                  80  


Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp Ala Ser Leu Thr 
                85                  90                  95      


Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr Arg Cys Asp Val 
            100                 105                 110         


Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser Leu Thr Val Asp 
        115                 120                 125             


Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg Tyr Thr Leu Asn 
    130                 135                 140                 


Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly Ala Val Ile Ala 
145                 150                 155                 160 


Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly Phe Glu Gln Cys 
                165                 170                 175     


Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr Pro Ile Arg Ala 
            180                 185                 190         


Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys Ala Gly Val Arg 
        195                 200                 205             


Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp Val Tyr Cys Tyr 
    210                 215                 220                 


Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr Val Pro Ser Lys 
225                 230                 235                 240 


Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn Gln Asp Ala Arg 
                245                 250                 255     


Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg Asn Gly Phe Asp 
            260                 265                 270         


Gln Cys Ala Tyr Gly Trp Leu Ser Asp Ala Ser Val Arg His Pro Val 
        275                 280                 285             


Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu Gly Val Arg Thr 
    290                 295                 300                 


Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro Pro Asp Ser Arg 
305                 310                 315                 320 


Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu Gly Asn Ser His His His 
                325                 330                 335     


His His His His His 
            340     


<210>  49
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Y296A

<400>  49

Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val Arg Gly Ser Leu 
1               5                   10                  15      


Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr Met Pro Thr Leu 
            20                  25                  30          


Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile Lys Trp Ser Lys 
        35                  40                  45              


Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu Thr Thr Val Leu 
    50                  55                  60                  


Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp Tyr Lys Gly Arg 
65                  70                  75                  80  


Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp Ala Ser Leu Thr 
                85                  90                  95      


Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr Arg Cys Asp Val 
            100                 105                 110         


Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser Leu Thr Val Asp 
        115                 120                 125             


Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg Tyr Thr Leu Asn 
    130                 135                 140                 


Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly Ala Val Ile Ala 
145                 150                 155                 160 


Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly Phe Glu Gln Cys 
                165                 170                 175     


Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr Pro Ile Arg Ala 
            180                 185                 190         


Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys Ala Gly Val Arg 
        195                 200                 205             


Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp Val Tyr Cys Tyr 
    210                 215                 220                 


Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr Val Pro Ser Lys 
225                 230                 235                 240 


Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn Gln Asp Ala Arg 
                245                 250                 255     


Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg Asn Gly Phe Asp 
            260                 265                 270         


Gln Cys Asp Ala Gly Trp Leu Ser Asp Ala Ser Val Arg His Pro Val 
        275                 280                 285             


Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu Gly Val Arg Thr 
    290                 295                 300                 


Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro Pro Asp Ser Arg 
305                 310                 315                 320 


Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu Gly Asn Ser His His His 
                325                 330                 335     


His His His His His 
            340     


<210>  50
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H306A

<400>  50

Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val Arg Gly Ser Leu 
1               5                   10                  15      


Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr Met Pro Thr Leu 
            20                  25                  30          


Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile Lys Trp Ser Lys 
        35                  40                  45              


Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu Thr Thr Val Leu 
    50                  55                  60                  


Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp Tyr Lys Gly Arg 
65                  70                  75                  80  


Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp Ala Ser Leu Thr 
                85                  90                  95      


Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr Arg Cys Asp Val 
            100                 105                 110         


Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser Leu Thr Val Asp 
        115                 120                 125             


Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg Tyr Thr Leu Asn 
    130                 135                 140                 


Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly Ala Val Ile Ala 
145                 150                 155                 160 


Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly Phe Glu Gln Cys 
                165                 170                 175     


Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr Pro Ile Arg Ala 
            180                 185                 190         


Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys Ala Gly Val Arg 
        195                 200                 205             


Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp Val Tyr Cys Tyr 
    210                 215                 220                 


Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr Val Pro Ser Lys 
225                 230                 235                 240 


Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn Gln Asp Ala Arg 
                245                 250                 255     


Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg Asn Gly Phe Asp 
            260                 265                 270         


Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val Arg Ala Pro Val 
        275                 280                 285             


Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu Gly Val Arg Thr 
    290                 295                 300                 


Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro Pro Asp Ser Arg 
305                 310                 315                 320 


Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu Gly Asn Ser His His His 
                325                 330                 335     


His His His His His 
            340     


<210>  51
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R312A

<400>  51

Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val Arg Gly Ser Leu 
1               5                   10                  15      


Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr Met Pro Thr Leu 
            20                  25                  30          


Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile Lys Trp Ser Lys 
        35                  40                  45              


Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu Thr Thr Val Leu 
    50                  55                  60                  


Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp Tyr Lys Gly Arg 
65                  70                  75                  80  


Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp Ala Ser Leu Thr 
                85                  90                  95      


Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr Arg Cys Asp Val 
            100                 105                 110         


Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser Leu Thr Val Asp 
        115                 120                 125             


Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg Tyr Thr Leu Asn 
    130                 135                 140                 


Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly Ala Val Ile Ala 
145                 150                 155                 160 


Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly Phe Glu Gln Cys 
                165                 170                 175     


Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr Pro Ile Arg Ala 
            180                 185                 190         


Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys Ala Gly Val Arg 
        195                 200                 205             


Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp Val Tyr Cys Tyr 
    210                 215                 220                 


Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr Val Pro Ser Lys 
225                 230                 235                 240 


Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn Gln Asp Ala Arg 
                245                 250                 255     


Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg Asn Gly Phe Asp 
            260                 265                 270         


Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val Arg His Pro Val 
        275                 280                 285             


Thr Val Ala Ala Ala Gln Cys Gly Gly Gly Leu Leu Gly Val Arg Thr 
    290                 295                 300                 


Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro Pro Asp Ser Arg 
305                 310                 315                 320 


Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu Gly Asn Ser His His His 
                325                 330                 335     


His His His His His 
            340     


<210>  52
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R312K

<400>  52

Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val Arg Gly Ser Leu 
1               5                   10                  15      


Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr Met Pro Thr Leu 
            20                  25                  30          


Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile Lys Trp Ser Lys 
        35                  40                  45              


Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu Thr Thr Val Leu 
    50                  55                  60                  


Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp Tyr Lys Gly Arg 
65                  70                  75                  80  


Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp Ala Ser Leu Thr 
                85                  90                  95      


Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr Arg Cys Asp Val 
            100                 105                 110         


Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser Leu Thr Val Asp 
        115                 120                 125             


Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg Tyr Thr Leu Asn 
    130                 135                 140                 


Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly Ala Val Ile Ala 
145                 150                 155                 160 


Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly Phe Glu Gln Cys 
                165                 170                 175     


Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr Pro Ile Arg Ala 
            180                 185                 190         


Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys Ala Gly Val Arg 
        195                 200                 205             


Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp Val Tyr Cys Tyr 
    210                 215                 220                 


Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr Val Pro Ser Lys 
225                 230                 235                 240 


Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn Gln Asp Ala Arg 
                245                 250                 255     


Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg Asn Gly Phe Asp 
            260                 265                 270         


Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val Arg His Pro Val 
        275                 280                 285             


Thr Val Ala Lys Ala Gln Cys Gly Gly Gly Leu Leu Gly Val Arg Thr 
    290                 295                 300                 


Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro Pro Asp Ser Arg 
305                 310                 315                 320 


Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu Gly Asn Ser His His His 
                325                 330                 335     


His His His His His 
            340     


<210>  53
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L325A

<400>  53

Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val Arg Gly Ser Leu 
1               5                   10                  15      


Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr Met Pro Thr Leu 
            20                  25                  30          


Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile Lys Trp Ser Lys 
        35                  40                  45              


Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu Thr Thr Val Leu 
    50                  55                  60                  


Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp Tyr Lys Gly Arg 
65                  70                  75                  80  


Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp Ala Ser Leu Thr 
                85                  90                  95      


Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr Arg Cys Asp Val 
            100                 105                 110         


Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser Leu Thr Val Asp 
        115                 120                 125             


Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg Tyr Thr Leu Asn 
    130                 135                 140                 


Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly Ala Val Ile Ala 
145                 150                 155                 160 


Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly Phe Glu Gln Cys 
                165                 170                 175     


Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr Pro Ile Arg Ala 
            180                 185                 190         


Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys Ala Gly Val Arg 
        195                 200                 205             


Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp Val Tyr Cys Tyr 
    210                 215                 220                 


Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr Val Pro Ser Lys 
225                 230                 235                 240 


Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn Gln Asp Ala Arg 
                245                 250                 255     


Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg Asn Gly Phe Asp 
            260                 265                 270         


Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val Arg His Pro Val 
        275                 280                 285             


Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu Gly Val Arg Thr 
    290                 295                 300                 


Ala Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro Pro Asp Ser Arg 
305                 310                 315                 320 


Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu Gly Asn Ser His His His 
                325                 330                 335     


His His His His His 
            340     


<210>  54
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Y326A

<400>  54

Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val Arg Gly Ser Leu 
1               5                   10                  15      


Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr Met Pro Thr Leu 
            20                  25                  30          


Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile Lys Trp Ser Lys 
        35                  40                  45              


Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu Thr Thr Val Leu 
    50                  55                  60                  


Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp Tyr Lys Gly Arg 
65                  70                  75                  80  


Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp Ala Ser Leu Thr 
                85                  90                  95      


Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr Arg Cys Asp Val 
            100                 105                 110         


Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser Leu Thr Val Asp 
        115                 120                 125             


Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg Tyr Thr Leu Asn 
    130                 135                 140                 


Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly Ala Val Ile Ala 
145                 150                 155                 160 


Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly Phe Glu Gln Cys 
                165                 170                 175     


Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr Pro Ile Arg Ala 
            180                 185                 190         


Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys Ala Gly Val Arg 
        195                 200                 205             


Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp Val Tyr Cys Tyr 
    210                 215                 220                 


Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr Val Pro Ser Lys 
225                 230                 235                 240 


Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn Gln Asp Ala Arg 
                245                 250                 255     


Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg Asn Gly Phe Asp 
            260                 265                 270         


Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val Arg His Pro Val 
        275                 280                 285             


Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu Gly Val Arg Thr 
    290                 295                 300                 


Leu Ala Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro Pro Asp Ser Arg 
305                 310                 315                 320 


Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu Gly Asn Ser His His His 
                325                 330                 335     


His His His His His 
            340     


<210>  55
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R327A

<400>  55

Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val Arg Gly Ser Leu 
1               5                   10                  15      


Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr Met Pro Thr Leu 
            20                  25                  30          


Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile Lys Trp Ser Lys 
        35                  40                  45              


Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu Thr Thr Val Leu 
    50                  55                  60                  


Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp Tyr Lys Gly Arg 
65                  70                  75                  80  


Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp Ala Ser Leu Thr 
                85                  90                  95      


Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr Arg Cys Asp Val 
            100                 105                 110         


Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser Leu Thr Val Asp 
        115                 120                 125             


Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg Tyr Thr Leu Asn 
    130                 135                 140                 


Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly Ala Val Ile Ala 
145                 150                 155                 160 


Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly Phe Glu Gln Cys 
                165                 170                 175     


Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr Pro Ile Arg Ala 
            180                 185                 190         


Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys Ala Gly Val Arg 
        195                 200                 205             


Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp Val Tyr Cys Tyr 
    210                 215                 220                 


Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr Val Pro Ser Lys 
225                 230                 235                 240 


Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn Gln Asp Ala Arg 
                245                 250                 255     


Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg Asn Gly Phe Asp 
            260                 265                 270         


Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val Arg His Pro Val 
        275                 280                 285             


Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu Gly Val Arg Thr 
    290                 295                 300                 


Leu Tyr Ala Phe Glu Asn Gln Thr Gly Phe Pro Pro Pro Asp Ser Arg 
305                 310                 315                 320 


Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu Gly Asn Ser His His His 
                325                 330                 335     


His His His His His 
            340     


<210>  56
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RY160KF

<400>  56

Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val Arg Gly Ser Leu 
1               5                   10                  15      


Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr Met Pro Thr Leu 
            20                  25                  30          


Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile Lys Trp Ser Lys 
        35                  40                  45              


Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu Thr Thr Val Leu 
    50                  55                  60                  


Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp Tyr Lys Gly Arg 
65                  70                  75                  80  


Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp Ala Ser Leu Thr 
                85                  90                  95      


Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr Arg Cys Asp Val 
            100                 105                 110         


Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser Leu Thr Val Asp 
        115                 120                 125             


Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Lys Phe Thr Leu Asn 
    130                 135                 140                 


Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly Ala Val Ile Ala 
145                 150                 155                 160 


Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly Phe Glu Gln Cys 
                165                 170                 175     


Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr Pro Ile Arg Ala 
            180                 185                 190         


Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys Ala Gly Val Arg 
        195                 200                 205             


Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp Val Tyr Cys Tyr 
    210                 215                 220                 


Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr Val Pro Ser Lys 
225                 230                 235                 240 


Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn Gln Asp Ala Arg 
                245                 250                 255     


Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg Asn Gly Phe Asp 
            260                 265                 270         


Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val Arg His Pro Val 
        275                 280                 285             


Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu Gly Val Arg Thr 
    290                 295                 300                 


Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro Pro Asp Ser Arg 
305                 310                 315                 320 


Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu Gly Asn Ser His His His 
                325                 330                 335     


His His His His His 
            340     


<210>  57
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LYR325LFK

<400>  57

Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val Arg Gly Ser Leu 
1               5                   10                  15      


Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr Met Pro Thr Leu 
            20                  25                  30          


Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile Lys Trp Ser Lys 
        35                  40                  45              


Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu Thr Thr Val Leu 
    50                  55                  60                  


Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp Tyr Lys Gly Arg 
65                  70                  75                  80  


Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp Ala Ser Leu Thr 
                85                  90                  95      


Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr Arg Cys Asp Val 
            100                 105                 110         


Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser Leu Thr Val Asp 
        115                 120                 125             


Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg Tyr Thr Leu Asn 
    130                 135                 140                 


Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly Ala Val Ile Ala 
145                 150                 155                 160 


Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly Phe Glu Gln Cys 
                165                 170                 175     


Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr Pro Ile Arg Ala 
            180                 185                 190         


Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys Ala Gly Val Arg 
        195                 200                 205             


Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp Val Tyr Cys Tyr 
    210                 215                 220                 


Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr Val Pro Ser Lys 
225                 230                 235                 240 


Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn Gln Asp Ala Arg 
                245                 250                 255     


Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg Asn Gly Phe Asp 
            260                 265                 270         


Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val Arg His Pro Val 
        275                 280                 285             


Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu Gly Val Arg Thr 
    290                 295                 300                 


Leu Phe Lys Phe Glu Asn Gln Thr Gly Phe Pro Pro Pro Asp Ser Arg 
305                 310                 315                 320 


Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu Gly Asn Ser His His His 
                325                 330                 335     


His His His His His 
            340     


<210>  58
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KF260RY

<400>  58

Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val Arg Gly Ser Leu 
1               5                   10                  15      


Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr Met Pro Thr Leu 
            20                  25                  30          


Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile Lys Trp Ser Lys 
        35                  40                  45              


Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu Thr Thr Val Leu 
    50                  55                  60                  


Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp Tyr Lys Gly Arg 
65                  70                  75                  80  


Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp Ala Ser Leu Thr 
                85                  90                  95      


Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr Arg Cys Asp Val 
            100                 105                 110         


Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser Leu Thr Val Asp 
        115                 120                 125             


Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg Tyr Thr Leu Asn 
    130                 135                 140                 


Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly Ala Val Ile Ala 
145                 150                 155                 160 


Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly Phe Glu Gln Cys 
                165                 170                 175     


Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr Pro Ile Arg Ala 
            180                 185                 190         


Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys Ala Gly Val Arg 
        195                 200                 205             


Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp Val Tyr Cys Tyr 
    210                 215                 220                 


Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr Val Pro Ser Arg 
225                 230                 235                 240 


Tyr Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn Gln Asp Ala Arg 
                245                 250                 255     


Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg Asn Gly Phe Asp 
            260                 265                 270         


Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val Arg His Pro Val 
        275                 280                 285             


Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu Gly Val Arg Thr 
    290                 295                 300                 


Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro Pro Asp Ser Arg 
305                 310                 315                 320 


Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu Gly Asn Ser His His His 
                325                 330                 335     


His His His His His 
            340     


<210>  59
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DY295SF

<400>  59

Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val Arg Gly Ser Leu 
1               5                   10                  15      


Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr Met Pro Thr Leu 
            20                  25                  30          


Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile Lys Trp Ser Lys 
        35                  40                  45              


Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu Thr Thr Val Leu 
    50                  55                  60                  


Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp Tyr Lys Gly Arg 
65                  70                  75                  80  


Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp Ala Ser Leu Thr 
                85                  90                  95      


Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr Arg Cys Asp Val 
            100                 105                 110         


Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser Leu Thr Val Asp 
        115                 120                 125             


Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg Tyr Thr Leu Asn 
    130                 135                 140                 


Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly Ala Val Ile Ala 
145                 150                 155                 160 


Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly Phe Glu Gln Cys 
                165                 170                 175     


Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr Pro Ile Arg Ala 
            180                 185                 190         


Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys Ala Gly Val Arg 
        195                 200                 205             


Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp Val Tyr Cys Tyr 
    210                 215                 220                 


Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr Val Pro Ser Lys 
225                 230                 235                 240 


Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn Gln Asp Ala Arg 
                245                 250                 255     


Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg Asn Gly Phe Asp 
            260                 265                 270         


Gln Cys Ser Phe Gly Trp Leu Ser Asp Ala Ser Val Arg His Pro Val 
        275                 280                 285             


Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu Gly Val Arg Thr 
    290                 295                 300                 


Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro Pro Asp Ser Arg 
305                 310                 315                 320 


Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu Gly Asn Ser His His His 
                325                 330                 335     


His His His His His 
            340     


<210>  60
<211>  334
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT VG1 consensus sequence


<220>
<221>  misc_feature
<222>  (189)..(189)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (204)..(204)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (212)..(212)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (242)..(242)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (280)..(280)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (290)..(290)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (296)..(296)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (309)..(311)
<223>  Xaa can be any naturally occurring amino acid

<400>  60

Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val Arg Gly Ser Leu 
1               5                   10                  15      


Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr Met Pro Thr Leu 
            20                  25                  30          


Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile Lys Trp Ser Lys 
        35                  40                  45              


Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu Thr Thr Val Leu 
    50                  55                  60                  


Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp Tyr Lys Gly Arg 
65                  70                  75                  80  


Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp Ala Ser Leu Thr 
                85                  90                  95      


Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr Arg Cys Asp Val 
            100                 105                 110         


Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser Leu Thr Val Asp 
        115                 120                 125             


Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg Tyr Thr Leu Asn 
    130                 135                 140                 


Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly Ala Val Ile Ala 
145                 150                 155                 160 


Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly Phe Glu Gln Cys 
                165                 170                 175     


Asp Ser Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Xaa Pro Ile Arg 
            180                 185                 190         


Ala Pro Arg Lys Val Gly Cys Tyr Gly Asp Lys Xaa Gly Lys Ala Gly 
        195                 200                 205             


Val Arg Thr Xaa Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp Val Tyr 
    210                 215                 220                 


Cys Tyr Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr Val Pro 
225                 230                 235                 240 


Ser Xaa Phe Tyr Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn Gln 
                245                 250                 255     


Asp Ala Arg Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg Asn 
            260                 265                 270         


Gly Phe Asp Gln Cys Asp Ser Xaa Gly Trp Leu Ser Asp Ala Ser Val 
        275                 280                 285             


Arg Xaa Pro Val Thr Val Ala Xaa Ala Gln Cys Gly Gly Gly Leu Leu 
    290                 295                 300                 


Gly Val Arg Thr Xaa Xaa Xaa Phe Glu Asn Gln Thr Gly Phe Pro Pro 
305                 310                 315                 320 


Pro Asp Ser Arg Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu 
                325                 330                 


<210>  61
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RabFab, LC

<400>  61

Ala Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Ala Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Gly Thr 
            20                  25                  30          


Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Ala Tyr Val Ser Gly 
                85                  90                  95      


Gly Asn Ile Tyr Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys Gly 
            100                 105                 110         


Asp Pro Val Ala Pro Thr Val Leu Ile Phe Pro Pro Ala Ala Asp Gln 
        115                 120                 125             


Val Ala Thr Gly Thr Val Thr Ile Val Cys Val Ala Asn Lys Tyr Phe 
    130                 135                 140                 


Pro Asp Val Thr Val Thr Trp Glu Val Asp Gly Thr Thr Gln Thr Thr 
145                 150                 155                 160 


Gly Ile Glu Asn Ser Lys Thr Pro Gln Asn Ser Ala Asp Cys Thr Tyr 
                165                 170                 175     


Asn Leu Ser Ser Thr Leu Thr Leu Thr Ser Thr Gln Tyr Asn Gly His 
            180                 185                 190         


Lys Glu Tyr Thr Cys Lys Val Thr Gln Gly Thr Thr Ser Val Val Gln 
        195                 200                 205             


Ser Phe Asn Arg Gly Asp Cys 
    210                 215 


<210>  62
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RabFab, HC

<400>  62

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Thr Ile Ser Ser Tyr His 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Met Arg Asn Thr Ala Asn Ile Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Pro Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Arg Pro Gly Asp Gly Ala Leu Ser Leu Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gln Pro Lys Ala Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Cys Gly Asp Thr Pro Ser Ser Thr Val Thr Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Gly Tyr Leu Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly 
145                 150                 155                 160 


Thr Leu Thr Asn Gly Val Arg Thr Phe Pro Ser Val Arg Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Ser Val Thr Ser Ser Ser Gln 
            180                 185                 190         


Pro Val Thr Cys Asn Val Ala His Pro Ala Thr Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Thr Val Ala Pro Ser Thr Cys Ser Lys Pro Thr 
    210                 215                 220 


<210>  63
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RabFab-VG1, LC

<400>  63

Ala Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Ala Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Gly Thr 
            20                  25                  30          


Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Ala Tyr Val Ser Gly 
                85                  90                  95      


Gly Asn Ile Tyr Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys Gly 
            100                 105                 110         


Asp Pro Val Ala Pro Thr Val Leu Ile Phe Pro Pro Ala Ala Asp Gln 
        115                 120                 125             


Val Ala Thr Gly Thr Val Thr Ile Val Cys Val Ala Asn Lys Tyr Phe 
    130                 135                 140                 


Pro Asp Val Thr Val Thr Trp Glu Val Asp Gly Thr Thr Gln Thr Thr 
145                 150                 155                 160 


Gly Ile Glu Asn Ser Lys Thr Pro Gln Asn Ser Ala Asp Cys Thr Tyr 
                165                 170                 175     


Asn Leu Ser Ser Thr Leu Thr Leu Thr Ser Thr Gln Tyr Asn Gly His 
            180                 185                 190         


Lys Glu Tyr Thr Cys Lys Val Thr Gln Gly Thr Thr Ser Val Val Gln 
        195                 200                 205             


Ser Phe Asn Arg Gly Asp Cys 
    210                 215 


<210>  64
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RabFab-VG1, HC

<400>  64

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Thr Ile Ser Ser Tyr His 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Met Arg Asn Thr Ala Asn Ile Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Pro Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Arg Pro Gly Asp Gly Ala Leu Ser Leu Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gln Pro Lys Ala Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Cys Gly Asp Thr Pro Ser Ser Thr Val Thr Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Gly Tyr Leu Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly 
145                 150                 155                 160 


Thr Leu Thr Asn Gly Val Arg Thr Phe Pro Ser Val Arg Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Ser Val Thr Ser Ser Ser Gln 
            180                 185                 190         


Pro Val Thr Cys Asn Val Ala His Pro Ala Thr Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Thr Val Ala Pro Ser Thr Cys Ser Lys Pro Thr Gly Gly Gly Gly 
    210                 215                 220                 


Ser Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val Arg Gly Ser 
225                 230                 235                 240 


Leu Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr Met Pro Thr 
                245                 250                 255     


Leu Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile Lys Trp Ser 
            260                 265                 270         


Lys Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu Thr Thr Val 
        275                 280                 285             


Leu Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp Tyr Lys Gly 
    290                 295                 300                 


Arg Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp Ala Ser Leu 
305                 310                 315                 320 


Thr Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr Arg Cys Asp 
                325                 330                 335     


Val Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser Leu Thr Val 
            340                 345                 350         


Asp Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg Tyr Thr Leu 
        355                 360                 365             


Asn Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly Ala Val Ile 
    370                 375                 380                 


Ala Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly Phe Glu Gln 
385                 390                 395                 400 


Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr Pro Ile Arg 
                405                 410                 415     


Ala Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys Ala Gly Val 
            420                 425                 430         


Arg Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp Val Tyr Cys 
        435                 440                 445             


Tyr Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr Val Pro Ser 
    450                 455                 460                 


Lys Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn Gln Asp Ala 
465                 470                 475                 480 


Arg Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg Asn Gly Phe 
                485                 490                 495     


Asp Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val Arg His Pro 
            500                 505                 510         


Val Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu Gly Val Arg 
        515                 520                 525             


Thr Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro Pro Asp Ser 
    530                 535                 540                 


Arg Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu Gly Asn Ser His His 
545                 550                 555                 560 


His His His His His His 
                565     


<210>  65
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PigFab-VG1, LC

<400>  65

Ala Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Val Ser Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Gln Ala Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Gly Asn Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu Lys Arg Ala Asp Ala Lys 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Lys Glu Gln Leu Glu Thr Gln 
        115                 120                 125             


Thr Val Ser Val Val Cys Leu Leu Asn Ser Phe Phe Pro Arg Glu Val 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Val Gln Ser Ser Gly Ile Leu 
145                 150                 155                 160 


Asp Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Ser Leu Pro Thr Ser Gln Tyr Leu Ser His Asn Leu Tyr 
            180                 185                 190         


Ser Cys Glu Val Thr His Lys Thr Leu Ala Ser Pro Leu Val Lys Ser 
        195                 200                 205             


Phe Ser Arg Asn Glu Cys Glu Ala 
    210                 215     


<210>  66
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PigFab-VG1, HC

<400>  66

Glu Glu Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Gly Ser Gly Phe Thr Ile Ser Asp Tyr 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ala Gly Ile Thr Pro Ala Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Gln Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Arg Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Val Phe Phe Leu Pro Tyr Ala Met Asp Tyr Trp Gly Pro 
            100                 105                 110         


Gly Val Glu Val Val Val Ser Ser Ala Pro Lys Thr Ala Pro Ser Val 
        115                 120                 125             


Tyr Pro Leu Ala Pro Cys Ser Arg Asp Thr Ser Gly Pro Asn Val Ala 
    130                 135                 140                 


Leu Gly Cys Leu Ala Ser Ser Tyr Phe Pro Glu Pro Val Thr Val Thr 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Ser Ser Gly Val His Thr Phe Pro Ser Val 
                165                 170                 175     


Leu Gln Pro Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro 
            180                 185                 190         


Ala Ser Ser Leu Ser Ser Lys Ser Tyr Thr Cys Asn Val Asn His Pro 
        195                 200                 205             


Ala Thr Thr Thr Lys Val Asp Lys Arg Val Gly Thr Lys Thr Lys Gly 
    210                 215                 220                 


Gly Gly Gly Ser Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val 
225                 230                 235                 240 


Arg Gly Ser Leu Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr 
                245                 250                 255     


Met Pro Thr Leu Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile 
            260                 265                 270         


Lys Trp Ser Lys Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu 
        275                 280                 285             


Thr Thr Val Leu Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp 
    290                 295                 300                 


Tyr Lys Gly Arg Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp 
305                 310                 315                 320 


Ala Ser Leu Thr Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr 
                325                 330                 335     


Arg Cys Asp Val Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser 
            340                 345                 350         


Leu Thr Val Asp Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg 
        355                 360                 365             


Tyr Thr Leu Asn Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly 
    370                 375                 380                 


Ala Val Ile Ala Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly 
385                 390                 395                 400 


Phe Glu Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr 
                405                 410                 415     


Pro Ile Arg Ala Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys 
            420                 425                 430         


Ala Gly Val Arg Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp 
        435                 440                 445             


Val Tyr Cys Tyr Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr 
    450                 455                 460                 


Val Pro Ser Lys Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn 
465                 470                 475                 480 


Gln Asp Ala Arg Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg 
                485                 490                 495     


Asn Gly Phe Asp Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val 
            500                 505                 510         


Arg His Pro Val Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu 
        515                 520                 525             


Gly Val Arg Thr Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro 
    530                 535                 540                 


Pro Asp Ser Arg Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu 
545                 550                 555             


<210>  67
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G6.31.Fab-VG1, LC

<400>  67

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Gly Ala Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  68
<211>  563
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G6.31.Fab-VG1 HC

<400>  68

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Asp Tyr 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Thr Pro Ala Gly Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Arg Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Val Phe Phe Leu Pro Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Gly Gly Gly Gly Ser Leu His Lys Val Lys Val Gly 
225                 230                 235                 240 


Lys Ser Pro Pro Val Arg Gly Ser Leu Ser Gly Lys Val Ser Leu Pro 
                245                 250                 255     


Cys His Phe Ser Thr Met Pro Thr Leu Pro Pro Ser Tyr Asn Thr Ser 
            260                 265                 270         


Glu Phe Leu Arg Ile Lys Trp Ser Lys Ile Glu Val Asp Lys Asn Gly 
        275                 280                 285             


Lys Asp Leu Lys Glu Thr Thr Val Leu Val Ala Gln Asn Gly Asn Ile 
    290                 295                 300                 


Lys Ile Gly Gln Asp Tyr Lys Gly Arg Val Ser Val Pro Thr His Pro 
305                 310                 315                 320 


Glu Ala Val Gly Asp Ala Ser Leu Thr Val Val Lys Leu Leu Ala Ser 
                325                 330                 335     


Asp Ala Gly Leu Tyr Arg Cys Asp Val Met Tyr Gly Ile Glu Asp Thr 
            340                 345                 350         


Gln Asp Thr Val Ser Leu Thr Val Asp Gly Val Val Phe His Tyr Arg 
        355                 360                 365             


Ala Ala Thr Ser Arg Tyr Thr Leu Asn Phe Glu Ala Ala Gln Lys Ala 
    370                 375                 380                 


Cys Leu Asp Val Gly Ala Val Ile Ala Thr Pro Glu Gln Leu Phe Ala 
385                 390                 395                 400 


Ala Tyr Glu Asp Gly Phe Glu Gln Cys Asp Ala Gly Trp Leu Ala Asp 
                405                 410                 415     


Gln Thr Val Arg Tyr Pro Ile Arg Ala Pro Arg Val Gly Cys Tyr Gly 
            420                 425                 430         


Asp Lys Met Gly Lys Ala Gly Val Arg Thr Tyr Gly Phe Arg Ser Pro 
        435                 440                 445             


Gln Glu Thr Tyr Asp Val Tyr Cys Tyr Val Asp His Leu Asp Gly Asp 
    450                 455                 460                 


Val Phe His Leu Thr Val Pro Ser Lys Phe Thr Phe Glu Glu Ala Ala 
465                 470                 475                 480 


Lys Glu Cys Glu Asn Gln Asp Ala Arg Leu Ala Thr Val Gly Glu Leu 
                485                 490                 495     


Gln Ala Ala Trp Arg Asn Gly Phe Asp Gln Cys Asp Tyr Gly Trp Leu 
            500                 505                 510         


Ser Asp Ala Ser Val Arg His Pro Val Thr Val Ala Arg Ala Gln Cys 
        515                 520                 525             


Gly Gly Gly Leu Leu Gly Val Arg Thr Leu Tyr Arg Phe Glu Asn Gln 
    530                 535                 540                 


Thr Gly Phe Pro Pro Pro Asp Ser Arg Phe Asp Ala Tyr Cys Phe Lys 
545                 550                 555                 560 


Pro Lys Glu 
            


<210>  69
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VPDF-VG1, LC

<400>  69

Ala Ile Tyr Met His Gln Glu Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Gly Ser Tyr Trp Leu Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Gly Lys Glu Arg Glu His Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser His Glu Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Arg Tyr His Pro Tyr 
                85                  90                  95      


Thr Phe Gly His Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  70
<211>  559
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VPDF-VG1, HC

<400>  70

Asp Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Asp Gly Trp Trp Phe Gly Tyr Thr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ser Ile Ser Tyr Lys Gly Gly Ser Thr Tyr Tyr Asn Thr Lys Phe 
    50                  55                  60                  


Ile Gly Arg Phe Thr Ile Ser Arg Asp Asp Asp Thr Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asp Gly Tyr Phe Asp Thr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Gly Gly Gly Gly Ser Leu His Lys Val Lys Val Gly Lys Ser Pro Pro 
225                 230                 235                 240 


Val Arg Gly Ser Leu Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser 
                245                 250                 255     


Thr Met Pro Thr Leu Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg 
            260                 265                 270         


Ile Lys Trp Ser Lys Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys 
        275                 280                 285             


Glu Thr Thr Val Leu Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln 
    290                 295                 300                 


Asp Tyr Lys Gly Arg Val Ser Val Pro Thr His Pro Glu Ala Val Gly 
305                 310                 315                 320 


Asp Ala Ser Leu Thr Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu 
                325                 330                 335     


Tyr Arg Cys Asp Val Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val 
            340                 345                 350         


Ser Leu Thr Val Asp Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser 
        355                 360                 365             


Arg Tyr Thr Leu Asn Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val 
    370                 375                 380                 


Gly Ala Val Ile Ala Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp 
385                 390                 395                 400 


Gly Phe Glu Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg 
                405                 410                 415     


Tyr Pro Ile Arg Ala Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly 
            420                 425                 430         


Lys Ala Gly Val Arg Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr 
        435                 440                 445             


Asp Val Tyr Cys Tyr Val Asp His Leu Asp Gly Asp Val Phe His Leu 
    450                 455                 460                 


Thr Val Pro Ser Lys Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu 
465                 470                 475                 480 


Asn Gln Asp Ala Arg Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp 
                485                 490                 495     


Arg Asn Gly Phe Asp Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser 
            500                 505                 510         


Val Arg His Pro Val Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu 
        515                 520                 525             


Leu Gly Val Arg Thr Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro 
    530                 535                 540                 


Pro Pro Asp Ser Arg Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu 
545                 550                 555                 


<210>  71
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VG1-Fc (2x)

<400>  71

Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val Arg Gly Ser Leu 
1               5                   10                  15      


Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr Met Pro Thr Leu 
            20                  25                  30          


Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile Lys Trp Ser Lys 
        35                  40                  45              


Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu Thr Thr Val Leu 
    50                  55                  60                  


Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp Tyr Lys Gly Arg 
65                  70                  75                  80  


Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp Ala Ser Leu Thr 
                85                  90                  95      


Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr Arg Cys Asp Val 
            100                 105                 110         


Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser Leu Thr Val Asp 
        115                 120                 125             


Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg Tyr Thr Leu Asn 
    130                 135                 140                 


Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly Ala Val Ile Ala 
145                 150                 155                 160 


Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly Phe Glu Gln Cys 
                165                 170                 175     


Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr Pro Ile Arg Ala 
            180                 185                 190         


Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys Ala Gly Val Arg 
        195                 200                 205             


Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp Val Tyr Cys Tyr 
    210                 215                 220                 


Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr Val Pro Ser Lys 
225                 230                 235                 240 


Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn Gln Asp Ala Arg 
                245                 250                 255     


Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg Asn Gly Phe Asp 
            260                 265                 270         


Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val Arg His Pro Val 
        275                 280                 285             


Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu Gly Val Arg Thr 
    290                 295                 300                 


Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro Pro Asp Ser Arg 
305                 310                 315                 320 


Phe Asp Ala Tyr Cys Phe Lys Arg Lys Cys Leu Ile Pro Phe Gly Asn 
                325                 330                 335     


Ser Val Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            340                 345                 350         


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        355                 360                 365             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    370                 375                 380                 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
385                 390                 395                 400 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                405                 410                 415     


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            420                 425                 430         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        435                 440                 445             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    450                 455                 460                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
465                 470                 475                 480 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                485                 490                 495     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            500                 505                 510         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        515                 520                 525             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    530                 535                 540                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
545                 550                 555                 560 


Ser Leu Ser Pro Gly Lys 
                565     


<210>  72
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VPDF-VG1?Ig, LC

<400>  72

Ala Ile Tyr Met His Gln Glu Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Gly Ser Tyr Trp Leu Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Gly Lys Glu Arg Glu His Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser His Glu Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Arg Tyr His Pro Tyr 
                85                  90                  95      


Thr Phe Gly His Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  73
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VPDF-VG1?Ig, HC

<400>  73

Asp Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Asp Gly Trp Trp Phe Gly Tyr Thr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ser Ile Ser Tyr Lys Gly Gly Ser Thr Tyr Tyr Asn Thr Lys Phe 
    50                  55                  60                  


Ile Gly Arg Phe Thr Ile Ser Arg Asp Asp Asp Thr Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asp Gly Tyr Phe Asp Thr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser 
225                 230                 235                 240 


Arg Tyr Thr Leu Asn Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val 
                245                 250                 255     


Gly Ala Val Ile Ala Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp 
            260                 265                 270         


Gly Phe Glu Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg 
        275                 280                 285             


Tyr Pro Ile Arg Ala Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly 
    290                 295                 300                 


Lys Ala Gly Val Arg Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr 
305                 310                 315                 320 


Asp Val Tyr Cys Tyr Val Asp His Leu Asp Gly Asp Val Phe His Leu 
                325                 330                 335     


Thr Val Pro Ser Lys Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu 
            340                 345                 350         


Asn Gln Asp Ala Arg Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp 
        355                 360                 365             


Arg Asn Gly Phe Asp Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser 
    370                 375                 380                 


Val Arg His Pro Val Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu 
385                 390                 395                 400 


Leu Gly Val Arg Thr Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro 
                405                 410                 415     


Pro Pro Asp Ser Arg Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu 
            420                 425                 430     


<210>  74
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  20D12v2.3-VG1, LC

<400>  74

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asp 
            20                  25                  30          


Val Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Gly Leu Ile 
        35                  40                  45              


Arg Ser Ala Ser Ser Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  75
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  20D12v2.3-VG1, HC

<400>  75

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Thr Ser Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Leu Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Gly 
    210                 215                 220                 


Gly Gly Gly Ser Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val 
225                 230                 235                 240 


Arg Gly Ser Leu Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr 
                245                 250                 255     


Met Pro Thr Leu Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile 
            260                 265                 270         


Lys Trp Ser Lys Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu 
        275                 280                 285             


Thr Thr Val Leu Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp 
    290                 295                 300                 


Tyr Lys Gly Arg Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp 
305                 310                 315                 320 


Ala Ser Leu Thr Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr 
                325                 330                 335     


Arg Cys Asp Val Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser 
            340                 345                 350         


Leu Thr Val Asp Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg 
        355                 360                 365             


Tyr Thr Leu Asn Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly 
    370                 375                 380                 


Ala Val Ile Ala Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly 
385                 390                 395                 400 


Phe Glu Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr 
                405                 410                 415     


Pro Ile Arg Ala Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys 
            420                 425                 430         


Ala Gly Val Arg Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp 
        435                 440                 445             


Val Tyr Cys Tyr Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr 
    450                 455                 460                 


Val Pro Ser Lys Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn 
465                 470                 475                 480 


Gln Asp Ala Arg Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg 
                485                 490                 495     


Asn Gly Phe Asp Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val 
            500                 505                 510         


Arg His Pro Val Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu 
        515                 520                 525             


Gly Val Arg Thr Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro 
    530                 535                 540                 


Pro Asp Ser Arg Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu 
545                 550                 555             


<210>  76
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ranibizumab-VG1, LC

<400>  76

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  77
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ranibizumab-VG1, HC

<400>  77

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Asp Phe Thr His Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  


Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Pro Tyr Tyr Tyr Gly Thr Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Gly Gly Gly Gly Leu His Lys Val Lys 
225                 230                 235                 240 


Val Gly Lys Ser Pro Pro Val Arg Gly Ser Leu Ser Gly Lys Val Ser 
                245                 250                 255     


Leu Pro Cys His Phe Ser Thr Met Pro Thr Leu Pro Pro Ser Tyr Asn 
            260                 265                 270         


Thr Ser Glu Phe Leu Arg Ile Lys Trp Ser Lys Ile Glu Val Asp Lys 
        275                 280                 285             


Asn Gly Lys Asp Leu Lys Glu Thr Thr Val Leu Val Ala Gln Asn Gly 
    290                 295                 300                 


Asn Ile Lys Ile Gly Gln Asp Tyr Lys Gly Arg Val Ser Val Pro Thr 
305                 310                 315                 320 


His Pro Glu Ala Val Gly Asp Ala Ser Leu Thr Val Val Lys Leu Leu 
                325                 330                 335     


Ala Ser Asp Ala Gly Leu Tyr Arg Cys Asp Val Met Tyr Gly Ile Glu 
            340                 345                 350         


Asp Thr Gln Asp Thr Val Ser Leu Thr Val Asp Gly Val Val Phe His 
        355                 360                 365             


Tyr Arg Ala Ala Thr Ser Arg Tyr Thr Leu Asn Phe Glu Ala Ala Gln 
    370                 375                 380                 


Lys Ala Cys Leu Asp Val Gly Ala Val Ile Ala Thr Pro Glu Gln Leu 
385                 390                 395                 400 


Phe Ala Ala Tyr Glu Asp Gly Phe Glu Gln Cys Asp Ala Gly Trp Leu 
                405                 410                 415     


Ala Asp Gln Thr Val Arg Tyr Pro Ile Arg Ala Pro Arg Val Gly Cys 
            420                 425                 430         


Tyr Gly Asp Lys Met Gly Lys Ala Gly Val Arg Thr Tyr Gly Phe Arg 
        435                 440                 445             


Ser Pro Gln Glu Thr Tyr Asp Val Tyr Cys Tyr Val Asp His Leu Asp 
    450                 455                 460                 


Gly Asp Val Phe His Leu Thr Val Pro Ser Lys Phe Thr Phe Glu Glu 
465                 470                 475                 480 


Ala Ala Lys Glu Cys Glu Asn Gln Asp Ala Arg Leu Ala Thr Val Gly 
                485                 490                 495     


Glu Leu Gln Ala Ala Trp Arg Asn Gly Phe Asp Gln Cys Asp Tyr Gly 
            500                 505                 510         


Trp Leu Ser Asp Ala Ser Val Arg His Pro Val Thr Val Ala Arg Ala 
        515                 520                 525             


Gln Cys Gly Gly Gly Leu Leu Gly Val Arg Thr Leu Tyr Arg Phe Glu 
    530                 535                 540                 


Asn Gln Thr Gly Phe Pro Pro Pro Asp Ser Arg Phe Asp Ala Tyr Cys 
545                 550                 555                 560 


Phe Lys Pro Lys Glu 
                565 


<210>  78
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EETI-VG1

<400>  78

Gly Cys Pro Arg Ile Leu Met Arg Cys Lys Gln Asp Ser Asp Cys Leu 
1               5                   10                  15      


Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys Gly Gly Ser Gly Ser 
            20                  25                  30          


Gly Ser Gly Ser Gly Ser Leu His Lys Val Lys Val Gly Lys Ser Pro 
        35                  40                  45              


Pro Val Arg Gly Ser Leu Ser Gly Lys Val Ser Leu Pro Cys His Phe 
    50                  55                  60                  


Ser Thr Met Pro Thr Leu Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu 
65                  70                  75                  80  


Arg Ile Lys Trp Ser Lys Ile Glu Val Asp Lys Asn Gly Lys Asp Leu 
                85                  90                  95      


Lys Glu Thr Thr Val Leu Val Ala Gln Asn Gly Asn Ile Lys Ile Gly 
            100                 105                 110         


Gln Asp Tyr Lys Gly Arg Val Ser Val Pro Thr His Pro Glu Ala Val 
        115                 120                 125             


Gly Asp Ala Ser Leu Thr Val Val Lys Leu Leu Ala Ser Asp Ala Gly 
    130                 135                 140                 


Leu Tyr Arg Cys Asp Val Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr 
145                 150                 155                 160 


Val Ser Leu Thr Val Asp Gly Val Val Phe His Tyr Arg Ala Ala Thr 
                165                 170                 175     


Ser Arg Tyr Thr Leu Asn Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp 
            180                 185                 190         


Val Gly Ala Val Ile Ala Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu 
        195                 200                 205             


Asp Gly Phe Glu Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr Val 
    210                 215                 220                 


Arg Tyr Pro Ile Arg Ala Pro Arg Val Gly Cys Tyr Gly Asp Lys Met 
225                 230                 235                 240 


Gly Lys Ala Gly Val Arg Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr 
                245                 250                 255     


Tyr Asp Val Tyr Cys Tyr Val Asp His Leu Asp Gly Asp Val Phe His 
            260                 265                 270         


Leu Thr Val Pro Ser Lys Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys 
        275                 280                 285             


Glu Asn Gln Asp Ala Arg Leu Ala Thr Val Gly Glu Leu Gln Ala Ala 
    290                 295                 300                 


Trp Arg Asn Gly Phe Asp Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala 
305                 310                 315                 320 


Ser Val Arg His Pro Val Thr Val Ala Arg Ala Gln Cys Gly Gly Gly 
                325                 330                 335     


Leu Leu Gly Val Arg Thr Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe 
            340                 345                 350         


Pro Pro Pro Asp Ser Arg Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu 
        355                 360                 365             


Gly Asn Ser His His His His His His His His 
    370                 375                 


<210>  79
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EETI-TEV-VG1

<400>  79

Gly Cys Pro Arg Ile Leu Met Arg Cys Lys Gln Asp Ser Asp Cys Leu 
1               5                   10                  15      


Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys Gly Glu Asn Leu Tyr 
            20                  25                  30          


Phe Gln Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Leu His Lys Val 
        35                  40                  45              


Lys Val Gly Lys Ser Pro Pro Val Arg Gly Ser Leu Ser Gly Lys Val 
    50                  55                  60                  


Ser Leu Pro Cys His Phe Ser Thr Met Pro Thr Leu Pro Pro Ser Tyr 
65                  70                  75                  80  


Asn Thr Ser Glu Phe Leu Arg Ile Lys Trp Ser Lys Ile Glu Val Asp 
                85                  90                  95      


Lys Asn Gly Lys Asp Leu Lys Glu Thr Thr Val Leu Val Ala Gln Asn 
            100                 105                 110         


Gly Asn Ile Lys Ile Gly Gln Asp Tyr Lys Gly Arg Val Ser Val Pro 
        115                 120                 125             


Thr His Pro Glu Ala Val Gly Asp Ala Ser Leu Thr Val Val Lys Leu 
    130                 135                 140                 


Leu Ala Ser Asp Ala Gly Leu Tyr Arg Cys Asp Val Met Tyr Gly Ile 
145                 150                 155                 160 


Glu Asp Thr Gln Asp Thr Val Ser Leu Thr Val Asp Gly Val Val Phe 
                165                 170                 175     


His Tyr Arg Ala Ala Thr Ser Arg Tyr Thr Leu Asn Phe Glu Ala Ala 
            180                 185                 190         


Gln Lys Ala Cys Leu Asp Val Gly Ala Val Ile Ala Thr Pro Glu Gln 
        195                 200                 205             


Leu Phe Ala Ala Tyr Glu Asp Gly Phe Glu Gln Cys Asp Ala Gly Trp 
    210                 215                 220                 


Leu Ala Asp Gln Thr Val Arg Tyr Pro Ile Arg Ala Pro Arg Val Gly 
225                 230                 235                 240 


Cys Tyr Gly Asp Lys Met Gly Lys Ala Gly Val Arg Thr Tyr Gly Phe 
                245                 250                 255     


Arg Ser Pro Gln Glu Thr Tyr Asp Val Tyr Cys Tyr Val Asp His Leu 
            260                 265                 270         


Asp Gly Asp Val Phe His Leu Thr Val Pro Ser Lys Phe Thr Phe Glu 
        275                 280                 285             


Glu Ala Ala Lys Glu Cys Glu Asn Gln Asp Ala Arg Leu Ala Thr Val 
    290                 295                 300                 


Gly Glu Leu Gln Ala Ala Trp Arg Asn Gly Phe Asp Gln Cys Asp Tyr 
305                 310                 315                 320 


Gly Trp Leu Ser Asp Ala Ser Val Arg His Pro Val Thr Val Ala Arg 
                325                 330                 335     


Ala Gln Cys Gly Gly Gly Leu Leu Gly Val Arg Thr Leu Tyr Arg Phe 
            340                 345                 350         


Glu Asn Gln Thr Gly Phe Pro Pro Pro Asp Ser Arg Phe Asp Ala Tyr 
        355                 360                 365             


Cys Phe Lys Pro Lys Glu Gly Asn Ser His His His His His His His 
    370                 375                 380                 


His 
385 


<210>  80
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VG1-EETI

<400>  80

Met Gly Gly Thr Ala Ala Arg Leu Gly Ala Val Ile Leu Phe Val Val 
1               5                   10                  15      


Ile Val Gly Leu His Gly Val Arg His His His His His His His His 
            20                  25                  30          


Gly Glu Asn Leu Tyr Phe Gln Gly Ser Leu His Lys Val Lys Val Gly 
        35                  40                  45              


Lys Ser Pro Pro Val Arg Gly Ser Leu Ser Gly Lys Val Ser Leu Pro 
    50                  55                  60                  


Cys His Phe Ser Thr Met Pro Thr Leu Pro Pro Ser Tyr Asn Thr Ser 
65                  70                  75                  80  


Glu Phe Leu Arg Ile Lys Trp Ser Lys Ile Glu Val Asp Lys Asn Gly 
                85                  90                  95      


Lys Asp Leu Lys Glu Thr Thr Val Leu Val Ala Gln Asn Gly Asn Ile 
            100                 105                 110         


Lys Ile Gly Gln Asp Tyr Lys Gly Arg Val Ser Val Pro Thr His Pro 
        115                 120                 125             


Glu Ala Val Gly Asp Ala Ser Leu Thr Val Val Lys Leu Leu Ala Ser 
    130                 135                 140                 


Asp Ala Gly Leu Tyr Arg Cys Asp Val Met Tyr Gly Ile Glu Asp Thr 
145                 150                 155                 160 


Gln Asp Thr Val Ser Leu Thr Val Asp Gly Val Val Phe His Tyr Arg 
                165                 170                 175     


Ala Ala Thr Ser Arg Tyr Thr Leu Asn Phe Glu Ala Ala Gln Lys Ala 
            180                 185                 190         


Cys Leu Asp Val Gly Ala Val Ile Ala Thr Pro Glu Gln Leu Phe Ala 
        195                 200                 205             


Ala Tyr Glu Asp Gly Phe Glu Gln Cys Asp Ala Gly Trp Leu Ala Asp 
    210                 215                 220                 


Gln Thr Val Arg Tyr Pro Ile Arg Ala Pro Arg Val Gly Cys Tyr Gly 
225                 230                 235                 240 


Asp Lys Met Gly Lys Ala Gly Val Arg Thr Tyr Gly Phe Arg Ser Pro 
                245                 250                 255     


Gln Glu Thr Tyr Asp Val Tyr Cys Tyr Val Asp His Leu Asp Gly Asp 
            260                 265                 270         


Val Phe His Leu Thr Val Pro Ser Lys Phe Thr Phe Glu Glu Ala Ala 
        275                 280                 285             


Lys Glu Cys Glu Asn Gln Asp Ala Arg Leu Ala Thr Val Gly Glu Leu 
    290                 295                 300                 


Gln Ala Ala Trp Arg Asn Gly Phe Asp Gln Cys Asp Tyr Gly Trp Leu 
305                 310                 315                 320 


Ser Asp Ala Ser Val Arg His Pro Val Thr Val Ala Arg Ala Gln Cys 
                325                 330                 335     


Gly Gly Gly Leu Leu Gly Val Arg Thr Leu Tyr Arg Phe Glu Asn Gln 
            340                 345                 350         


Thr Gly Phe Pro Pro Pro Asp Ser Arg Phe Asp Ala Tyr Cys Phe Lys 
        355                 360                 365             


Pro Lys Glu Gly Asn Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
    370                 375                 380                 


Gly Cys Pro Arg Ile Leu Met Arg Cys Lys Gln Asp Ser Asp Cys Leu 
385                 390                 395                 400 


Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys Gly 
                405                 410         


<210>  81
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VG1-TEV-EETI

<400>  81

Met Gly Gly Thr Ala Ala Arg Leu Gly Ala Val Ile Leu Phe Val Val 
1               5                   10                  15      


Ile Val Gly Leu His Gly Val Arg His His His His His His His His 
            20                  25                  30          


Gly Glu Asn Leu Tyr Phe Gln Gly Ser Leu His Lys Val Lys Val Gly 
        35                  40                  45              


Lys Ser Pro Pro Val Arg Gly Ser Leu Ser Gly Lys Val Ser Leu Pro 
    50                  55                  60                  


Cys His Phe Ser Thr Met Pro Thr Leu Pro Pro Ser Tyr Asn Thr Ser 
65                  70                  75                  80  


Glu Phe Leu Arg Ile Lys Trp Ser Lys Ile Glu Val Asp Lys Asn Gly 
                85                  90                  95      


Lys Asp Leu Lys Glu Thr Thr Val Leu Val Ala Gln Asn Gly Asn Ile 
            100                 105                 110         


Lys Ile Gly Gln Asp Tyr Lys Gly Arg Val Ser Val Pro Thr His Pro 
        115                 120                 125             


Glu Ala Val Gly Asp Ala Ser Leu Thr Val Val Lys Leu Leu Ala Ser 
    130                 135                 140                 


Asp Ala Gly Leu Tyr Arg Cys Asp Val Met Tyr Gly Ile Glu Asp Thr 
145                 150                 155                 160 


Gln Asp Thr Val Ser Leu Thr Val Asp Gly Val Val Phe His Tyr Arg 
                165                 170                 175     


Ala Ala Thr Ser Arg Tyr Thr Leu Asn Phe Glu Ala Ala Gln Lys Ala 
            180                 185                 190         


Cys Leu Asp Val Gly Ala Val Ile Ala Thr Pro Glu Gln Leu Phe Ala 
        195                 200                 205             


Ala Tyr Glu Asp Gly Phe Glu Gln Cys Asp Ala Gly Trp Leu Ala Asp 
    210                 215                 220                 


Gln Thr Val Arg Tyr Pro Ile Arg Ala Pro Arg Val Gly Cys Tyr Gly 
225                 230                 235                 240 


Asp Lys Met Gly Lys Ala Gly Val Arg Thr Tyr Gly Phe Arg Ser Pro 
                245                 250                 255     


Gln Glu Thr Tyr Asp Val Tyr Cys Tyr Val Asp His Leu Asp Gly Asp 
            260                 265                 270         


Val Phe His Leu Thr Val Pro Ser Lys Phe Thr Phe Glu Glu Ala Ala 
        275                 280                 285             


Lys Glu Cys Glu Asn Gln Asp Ala Arg Leu Ala Thr Val Gly Glu Leu 
    290                 295                 300                 


Gln Ala Ala Trp Arg Asn Gly Phe Asp Gln Cys Asp Tyr Gly Trp Leu 
305                 310                 315                 320 


Ser Asp Ala Ser Val Arg His Pro Val Thr Val Ala Arg Ala Gln Cys 
                325                 330                 335     


Gly Gly Gly Leu Leu Gly Val Arg Thr Leu Tyr Arg Phe Glu Asn Gln 
            340                 345                 350         


Thr Gly Phe Pro Pro Pro Asp Ser Arg Phe Asp Ala Tyr Cys Phe Lys 
        355                 360                 365             


Pro Lys Glu Gly Asn Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
    370                 375                 380                 


Glu Asn Leu Tyr Phe Gln Gly Gly Cys Pro Arg Ile Leu Met Arg Cys 
385                 390                 395                 400 


Lys Gln Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly 
                405                 410                 415     


Phe Cys Gly 
            


<210>  82
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker for VG1-Fc (2x)

<400>  82

Arg Lys Cys Leu Ile Pro Phe Gly Asn Ser Val Thr 
1               5                   10          


<210>  83
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker for Ranibizumab-VG1

<400>  83

Gly Gly Gly Gly 
1               


<210>  84
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker for EETI-VG1, VG1-EETI

<400>  84

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10  


<210>  85
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker for EETI-TEV-VG1, VG1-TEV-EETI

<400>  85

Glu Asn Leu Tyr Phe Gln Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10                  15      


<210>  86
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VG1?Ig consensus sequence


<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (113)..(113)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (151)..(151)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (161)..(161)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (167)..(167)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (180)..(182)
<223>  Xaa can be any naturally occurring amino acid

<400>  86

Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg Tyr Thr Leu Asn Phe 
1               5                   10                  15      


Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly Ala Val Ile Ala Thr 
            20                  25                  30          


Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly Phe Glu Gln Cys Asp 
        35                  40                  45              


Ser Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Xaa Pro Ile Arg Ala 
    50                  55                  60                  


Pro Arg Lys Val Gly Cys Tyr Gly Asp Lys Xaa Gly Lys Ala Gly Val 
65                  70                  75                  80  


Arg Thr Xaa Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp Val Tyr Cys 
                85                  90                  95      


Tyr Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr Val Pro Ser 
            100                 105                 110         


Xaa Phe Tyr Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn Gln Asp 
        115                 120                 125             


Ala Arg Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg Asn Gly 
    130                 135                 140                 


Phe Asp Gln Cys Asp Ser Xaa Gly Trp Leu Ser Asp Ala Ser Val Arg 
145                 150                 155                 160 


Xaa Pro Val Thr Val Ala Xaa Ala Gln Cys Gly Gly Gly Leu Leu Gly 
                165                 170                 175     


Val Arg Thr Xaa Xaa Xaa Phe Glu Asn Gln Thr Gly Phe Pro Pro Pro 
            180                 185                 190         


Asp Ser Arg Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu 
        195                 200                 205 


<210>  87
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  87

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10          


<210>  88
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  88

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  89
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  89

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
1               5                   10              


<210>  90
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  90

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10      


<210>  91
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  91

Gly Gly Gly Ser 
1               


<210>  92
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-VEGF cysteine knot peptide (CKP) for VG1 fusion modified 
       L3.54.90.67.F8Y.M5 VC072M

<400>  92

Gly Cys Asn Ile Met Leu Pro Tyr Trp Gly Cys Gly Arg Asp Phe Glu 
1               5                   10                  15      


Cys Met Glu Gln Cys Ile Cys Gln Tyr Tyr Gln Ser Cys Gly 
            20                  25                  30  


<210>  93
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion 5; VC072M.GS10X.VG1CTH

<400>  93

Gly Cys Asn Ile Met Leu Pro Tyr Trp Gly Cys Gly Arg Asp Phe Glu 
1               5                   10                  15      


Cys Met Glu Gln Cys Ile Cys Gln Tyr Tyr Gln Ser Cys Gly 
            20                  25                  30  


<210>  94
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion 6; VG1NTH.GS10X.VC072M

<400>  94

Gly Cys Asn Ile Met Leu Pro Tyr Trp Gly Cys Gly Arg Asp Phe Glu 
1               5                   10                  15      


Cys Met Glu Gln Cys Ile Cys Gln Tyr Tyr Gln Ser Cys Gly 
            20                  25                  30  


<210>  95
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker used in SEQ ID NOs: 93 and 94

<400>  95

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10                  15      


Gly Ser Gly Ser 
            20  


<210>  96
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD44-ko domain

<400>  96

Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly Val Phe His 
1               5                   10                  15      


Val Glu Lys Asn Gly Arg Ser Ser Ile Ser Arg Thr Glu Ala Ala Asp 
            20                  25                  30          


Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala Gln Met Glu 
        35                  40                  45              


Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly Phe Ile Glu 
    50                  55                  60                  


Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile Cys Ala Ala 
65                  70                  75                  80  


Asn Asn Thr Gly Val Tyr Ile Leu Thr Tyr Asn Thr Ser Gln Tyr Asp 
                85                  90                  95      


Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp Cys Thr Ser 
            100                 105                 110         


Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr Ile Thr Ile 
        115                 120                 125             


Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu Tyr Arg Thr 
    130                 135                 140                 


Asn Pro Glu Asp Ile Tyr 
145                 150 


<210>  97
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PigFab VH

<400>  97

Glu Glu Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Gly Ser Gly Phe Thr Ile Ser Asp Tyr 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ala Gly Ile Thr Pro Ala Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Gln Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Arg Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Val Phe Phe Leu Pro Tyr Ala Met Asp Tyr Trp Gly Pro 
            100                 105                 110         


Gly Val Glu Val Val Val Ser Ser 
        115                 120 


<210>  98
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PigFab VL

<400>  98

Ala Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Val Ser Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Gln Ala Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Gly Asn Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  99
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VPDF VH

<400>  99

Asp Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Asp Gly Trp Trp Phe Gly Tyr Thr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ser Ile Ser Tyr Lys Gly Gly Ser Thr Tyr Tyr Asn Thr Lys Phe 
    50                  55                  60                  


Ile Gly Arg Phe Thr Ile Ser Arg Asp Asp Asp Thr Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asp Gly Tyr Phe Asp Thr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  100
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VPDF VL

<400>  100

Ala Ile Tyr Met His Gln Glu Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Gly Ser Tyr Trp Leu Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Gly Lys Glu Arg Glu His Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser His Glu Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Arg Tyr His Pro Tyr 
                85                  90                  95      


Thr Phe Gly His Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  101
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VPDF (unmodified) HC

<400>  101

Asp Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Asp Gly Trp Trp Phe Gly Tyr Thr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ser Ile Ser Tyr Lys Gly Gly Ser Thr Tyr Tyr Asn Thr Lys Phe 
    50                  55                  60                  


Ile Gly Arg Phe Thr Ile Ser Arg Asp Asp Asp Thr Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asp Gly Tyr Phe Asp Thr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


<210>  102
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VPDF (unmodified) LC

<400>  102

Ala Ile Tyr Met His Gln Glu Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Gly Ser Tyr Trp Leu Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Gly Lys Glu Arg Glu His Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser His Glu Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Arg Tyr His Pro Tyr 
                85                  90                  95      


Thr Phe Gly His Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  103
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G6.31 Fab (unmodified) HC

<400>  103

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Asp Tyr 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Thr Pro Ala Gly Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Arg Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Val Phe Phe Leu Pro Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr 
225             


<210>  104
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G6.31 Fab (unmodified) LC

<400>  104

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Gly Ala Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  105
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G6.31 VH

<400>  105

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Asp Tyr 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Thr Pro Ala Gly Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Arg Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Val Phe Phe Leu Pro Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  106
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G6.31 VL

<400>  106

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Gly Ala Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  107
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RabFab VH

<400>  107

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Thr Ile Ser Ser Tyr His 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Met Arg Asn Thr Ala Asn Ile Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Pro Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Arg Pro Gly Asp Gly Ala Leu Ser Leu Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  108
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RabFab VL

<400>  108

Ala Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Ala Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Gly Thr 
            20                  25                  30          


Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Ala Tyr Val Ser Gly 
                85                  90                  95      


Gly Asn Ile Tyr Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110     


<210>  109
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NVS24 VH

<400>  109

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Tyr Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Gly Phe Ile Asp Pro Gln Asn Asp Pro Tyr Tyr Ala Thr Trp Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Gly Asn His Asn Ser Gly Trp Gly Leu Asn Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  110
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NVS24 VL

<400>  110

Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ile Ile Thr Cys Gln Ala Ser Gln Lys Ile His Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gln Ala Ser Lys Leu Ala Lys Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Tyr Leu Ala Ser Thr 
                85                  90                  95      


Asn Gly Ala Asn Phe Gly Gln Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  111
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  20D12v2.3 VH

<400>  111

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Thr Ser Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Leu Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  112
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  20D12v2.3 VL

<400>  112

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asp 
            20                  25                  30          


Val Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Gly Leu Ile 
        35                  40                  45              


Arg Ser Ala Ser Ser Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  113
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSG6 (Lava12)

<400>  113

Gly Val Tyr His Arg Glu Ala Ile Ser Gly Lys Tyr Tyr Leu Thr Tyr 
1               5                   10                  15      


Ala Glu Ala Lys Ala Val Cys Glu Phe Glu Gly Gly His Leu Ala Thr 
            20                  25                  30          


Tyr Lys Gln Leu Leu Ala Ala Gln Lys Ile Gly Phe His Val Cys Ala 
        35                  40                  45              


Ala Gly Trp Met Ala Lys Gly Arg Val Gly Tyr Pro Ile Val Lys Pro 
    50                  55                  60                  


Gly Pro Asn Cys Gly Phe Gly Lys Thr Gly Ile Ile Asp Tyr Gly Ile 
65                  70                  75                  80  


Arg Leu Asn Arg Ser Glu Arg Trp Asp Ala Tyr Cys Tyr Asn Pro His 
                85                  90                  95      


Ala 
    


<210>  114
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ranibizumab VH

<400>  114

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Asp Phe Thr His Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  


Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Pro Tyr Tyr Tyr Gly Thr Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  115
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ranibizumab VL

<400>  115

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  116
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-HtrA1 VH

<400>  116

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Asp Ser 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Val Asp Pro Glu Thr Glu Gly Ala Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Thr Arg Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Tyr Asp Tyr Asp Tyr Ala Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  117
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-HtrA1 VL

<400>  117

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Glu Phe Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile Ser 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Ala Pro Trp Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  118
<211>  561
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-HtrA1-VG1 HC

<400>  118

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Asp Ser 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Val Asp Pro Glu Thr Glu Gly Ala Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Thr Arg Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Tyr Asp Tyr Asp Tyr Ala Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Gly Gly Gly Gly Leu His Lys Val Lys Val Gly Lys Ser 
225                 230                 235                 240 


Pro Pro Val Arg Gly Ser Leu Ser Gly Lys Val Ser Leu Pro Cys His 
                245                 250                 255     


Phe Ser Thr Met Pro Thr Leu Pro Pro Ser Tyr Asn Thr Ser Glu Phe 
            260                 265                 270         


Leu Arg Ile Lys Trp Ser Lys Ile Glu Val Asp Lys Asn Gly Lys Asp 
        275                 280                 285             


Leu Lys Glu Thr Thr Val Leu Val Ala Gln Asn Gly Asn Ile Lys Ile 
    290                 295                 300                 


Gly Gln Asp Tyr Lys Gly Arg Val Ser Val Pro Thr His Pro Glu Ala 
305                 310                 315                 320 


Val Gly Asp Ala Ser Leu Thr Val Val Lys Leu Leu Ala Ser Asp Ala 
                325                 330                 335     


Gly Leu Tyr Arg Cys Asp Val Met Tyr Gly Ile Glu Asp Thr Gln Asp 
            340                 345                 350         


Thr Val Ser Leu Thr Val Asp Gly Val Val Phe His Tyr Arg Ala Ala 
        355                 360                 365             


Thr Ser Arg Tyr Thr Leu Asn Phe Glu Ala Ala Gln Lys Ala Cys Leu 
    370                 375                 380                 


Asp Val Gly Ala Val Ile Ala Thr Pro Glu Gln Leu Phe Ala Ala Tyr 
385                 390                 395                 400 


Glu Asp Gly Phe Glu Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr 
                405                 410                 415     


Val Arg Tyr Pro Ile Arg Ala Pro Arg Val Gly Cys Tyr Gly Asp Lys 
            420                 425                 430         


Met Gly Lys Ala Gly Val Arg Thr Tyr Gly Phe Arg Ser Pro Gln Glu 
        435                 440                 445             


Thr Tyr Asp Val Tyr Cys Tyr Val Asp His Leu Asp Gly Asp Val Phe 
    450                 455                 460                 


His Leu Thr Val Pro Ser Lys Phe Thr Phe Glu Glu Ala Ala Lys Glu 
465                 470                 475                 480 


Cys Glu Asn Gln Asp Ala Arg Leu Ala Thr Val Gly Glu Leu Gln Ala 
                485                 490                 495     


Ala Trp Arg Asn Gly Phe Asp Gln Cys Asp Tyr Gly Trp Leu Ser Asp 
            500                 505                 510         


Ala Ser Val Arg His Pro Val Thr Val Ala Arg Ala Gln Cys Gly Gly 
        515                 520                 525             


Gly Leu Leu Gly Val Arg Thr Leu Tyr Arg Phe Glu Asn Gln Thr Gly 
    530                 535                 540                 


Phe Pro Pro Pro Asp Ser Arg Phe Asp Ala Tyr Cys Phe Lys Pro Lys 
545                 550                 555                 560 


Glu 
    


<210>  119
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-HtrA1-VG1 LC

<400>  119

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Glu Phe Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile Ser 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Ala Pro Trp Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  120
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-gD Fab HC

<400>  120

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Phe Ala Trp Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Gly Tyr Ile Ser Tyr Ser Gly Thr Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Phe Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asn Tyr Tyr Gly Arg Ser His Val Gly Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr 
225                 230     


<210>  121
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-gD Fab LC (also referred to herein as Anti-gD IgG LC and 
       Anti-gD Fab-VG1 LC of BRD)

<400>  121

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ala Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asp Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Tyr 
                85                  90                  95      


Ala Asp Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  122
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-gD IgG HC

<400>  122

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Phe Ala Trp Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Gly Tyr Ile Ser Tyr Ser Gly Thr Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Phe Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asn Tyr Tyr Gly Arg Ser His Val Gly Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  123
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-gD Fab-VG1 HC of BRD

<400>  123

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Phe Ala Trp Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Gly Tyr Ile Ser Tyr Ser Gly Thr Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Phe Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asn Tyr Tyr Gly Arg Ser His Val Gly Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Gly Gly Gly Gly Ser Leu His Lys Val 
225                 230                 235                 240 


Lys Val Gly Lys Ser Pro Pro Val Arg Gly Ser Leu Ser Gly Lys Val 
                245                 250                 255     


Ser Leu Pro Cys His Phe Ser Thr Met Pro Thr Leu Pro Pro Ser Tyr 
            260                 265                 270         


Asn Thr Ser Glu Phe Leu Arg Ile Lys Trp Ser Lys Ile Glu Val Asp 
        275                 280                 285             


Lys Asn Gly Lys Asp Leu Lys Glu Thr Thr Val Leu Val Ala Gln Asn 
    290                 295                 300                 


Gly Asn Ile Lys Ile Gly Gln Asp Tyr Lys Gly Arg Val Ser Val Pro 
305                 310                 315                 320 


Thr His Pro Glu Ala Val Gly Asp Ala Ser Leu Thr Val Val Lys Leu 
                325                 330                 335     


Leu Ala Ser Asp Ala Gly Leu Tyr Arg Cys Asp Val Met Tyr Gly Ile 
            340                 345                 350         


Glu Asp Thr Gln Asp Thr Val Ser Leu Thr Val Asp Gly Val Val Phe 
        355                 360                 365             


His Tyr Arg Ala Ala Thr Ser Arg Tyr Thr Leu Asn Phe Glu Ala Ala 
    370                 375                 380                 


Gln Lys Ala Cys Leu Asp Val Gly Ala Val Ile Ala Thr Pro Glu Gln 
385                 390                 395                 400 


Leu Phe Ala Ala Tyr Glu Asp Gly Phe Glu Gln Cys Asp Ala Gly Trp 
                405                 410                 415     


Leu Ala Asp Gln Thr Val Arg Tyr Pro Ile Arg Ala Pro Arg Val Gly 
            420                 425                 430         


Cys Tyr Gly Asp Lys Met Gly Lys Ala Gly Val Arg Thr Tyr Gly Phe 
        435                 440                 445             


Arg Ser Pro Gln Glu Thr Tyr Asp Val Tyr Cys Tyr Val Asp His Leu 
    450                 455                 460                 


Asp Gly Asp Val Phe His Leu Thr Val Pro Ser Lys Phe Thr Phe Glu 
465                 470                 475                 480 


Glu Ala Ala Lys Glu Cys Glu Asn Gln Asp Ala Arg Leu Ala Thr Val 
                485                 490                 495     


Gly Glu Leu Gln Ala Ala Trp Arg Asn Gly Phe Asp Gln Cys Asp Tyr 
            500                 505                 510         


Gly Trp Leu Ser Asp Ala Ser Val Arg His Pro Val Thr Val Ala Arg 
        515                 520                 525             


Ala Gln Cys Gly Gly Gly Leu Leu Gly Val Arg Thr Leu Tyr Arg Phe 
    530                 535                 540                 


Glu Asn Gln Thr Gly Phe Pro Pro Pro Asp Ser Arg Phe Asp Ala Tyr 
545                 550                 555                 560 


Cys Phe Lys Pro Lys Glu 
                565     


