                         SEQUENCE LISTING

<110>  F. Hoffmann-La Roche AG
       Hoffmann-La Roche Inc.
 
<120>  Nucleic acid constructs for simultaneous gene activation

<130>   P36312

<150>  EP20202009.5
<151>  2020-10-15

<160>  89    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lx site spacer sequence

<400>  1
agtttata                                                                 8


<210>  2
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lx site reverse orientation

<400>  2
tataaact                                                                 8


<210>  3
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lx-LE mutant

<400>  3
taccgttcgt ataagtttat atatacgaag ttat                                   34


<210>  4
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lx-LE mutant reverse orientation

<400>  4
ataacttcgt atatataaac ttatacgaac ggta                                   34


<210>  5
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lx-RE mutant

<400>  5
ataacttcgt ataagtttat atatacgaac ggta                                   34


<210>  6
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lx-RE mutant reverse orientation

<400>  6
taccgttcgt atatataaac ttatacgaag ttat                                   34


<210>  7
<211>  343
<212>  PRT
<213>  Bacteriophage P1

<400>  7

Met Ser Asn Leu Leu Thr Val His Gln Asn Leu Pro Ala Leu Pro Val 
1               5                   10                  15      


Asp Ala Thr Ser Asp Glu Val Arg Lys Asn Leu Met Asp Met Phe Arg 
            20                  25                  30          


Asp Arg Gln Ala Phe Ser Glu His Thr Trp Lys Met Leu Leu Ser Val 
        35                  40                  45              


Cys Arg Ser Trp Ala Ala Trp Cys Lys Leu Asn Asn Arg Lys Trp Phe 
    50                  55                  60                  


Pro Ala Glu Pro Glu Asp Val Arg Asp Tyr Leu Leu Tyr Leu Gln Ala 
65                  70                  75                  80  


Arg Gly Leu Ala Val Lys Thr Ile Gln Gln His Leu Gly Gln Leu Asn 
                85                  90                  95      


Met Leu His Arg Arg Ser Gly Leu Pro Arg Pro Ser Asp Ser Asn Ala 
            100                 105                 110         


Val Ser Leu Val Met Arg Arg Ile Arg Lys Glu Asn Val Asp Ala Gly 
        115                 120                 125             


Glu Arg Ala Lys Gln Ala Leu Ala Phe Glu Arg Thr Asp Phe Asp Gln 
    130                 135                 140                 


Val Arg Ser Leu Met Glu Asn Ser Asp Arg Cys Gln Asp Ile Arg Asn 
145                 150                 155                 160 


Leu Ala Phe Leu Gly Ile Ala Tyr Asn Thr Leu Leu Arg Ile Ala Glu 
                165                 170                 175     


Ile Ala Arg Ile Arg Val Lys Asp Ile Ser Arg Thr Asp Gly Gly Arg 
            180                 185                 190         


Met Leu Ile His Ile Gly Arg Thr Lys Thr Leu Val Ser Thr Ala Gly 
        195                 200                 205             


Val Glu Lys Ala Leu Ser Leu Gly Val Thr Lys Leu Val Glu Arg Trp 
    210                 215                 220                 


Ile Ser Val Ser Gly Val Ala Asp Asp Pro Asn Asn Tyr Leu Phe Cys 
225                 230                 235                 240 


Arg Val Arg Lys Asn Gly Val Ala Ala Pro Ser Ala Thr Ser Gln Leu 
                245                 250                 255     


Ser Thr Arg Ala Leu Glu Gly Ile Phe Glu Ala Thr His Arg Leu Ile 
            260                 265                 270         


Tyr Gly Ala Lys Asp Asp Ser Gly Gln Arg Tyr Leu Ala Trp Ser Gly 
        275                 280                 285             


His Ser Ala Arg Val Gly Ala Ala Arg Asp Met Ala Arg Ala Gly Val 
    290                 295                 300                 


Ser Ile Pro Glu Ile Met Gln Ala Gly Gly Trp Thr Asn Val Asn Ile 
305                 310                 315                 320 


Val Met Asn Tyr Ile Arg Asn Leu Asp Ser Glu Thr Gly Ala Met Val 
                325                 330                 335     


Arg Leu Leu Glu Asp Gly Asp 
            340             


<210>  8
<211>  1029
<212>  RNA
<213>  Bacteriophage P1

<400>  8
augagcaacc ugcugaccgu gcaccagaac cugcccgccc ugcccgugga cgccaccagc       60

gacgagguga ggaagaaccu gauggacaug uucagggaca ggcaggccuu cagcgagcac      120

accuggaaga ugcugcugag cgugugcagg agcugggccg ccuggugcaa gcugaacaac      180

aggaaguggu uccccgccga gcccgaggac gugagggacu accugcugua ccugcaggcc      240

aggggccugg ccgugaagac cauccagcag caccugggcc agcugaacau gcugcacagg      300

aggagcggcc ugcccaggcc cagcgacagc aacgccguga gccuggugau gaggaggauc      360

aggaaggaga acguggacgc cggcgagagg gccaagcagg cccuggccuu cgagaggacc      420

gacuucgacc aggugaggag ccugauggag aacagcgaca ggugccagga caucaggaac      480

cuggccuucc ugggcaucgc cuacaacacc cugcugagga ucgccgagau cgccaggauc      540

agggugaagg acaucagcag gaccgacggc ggcaggaugc ugauccacau cggcaggacc      600

aagacccugg ugagcaccgc cggcguggag aaggcccuga gccugggcgu gaccaagcug      660

guggagaggu ggaucagcgu gagcggcgug gccgacgacc ccaacaacua ccuguucugc      720

agggugagga agaacggcgu ggccgccccc agcgccacca gccagcugag caccagggcc      780

cuggagggca ucuucgaggc cacccacagg cugaucuacg gcgccaagga cgacagcggc      840

cagagguacc uggccuggag cggccacagc gccagggugg gcgccgccag ggacauggcc      900

agggccggcg ugagcauccc cgagaucaug caggccggcg gcuggaccaa cgugaacauc      960

gugaugaacu acaucaggaa ccuggacagc gagaccggcg ccauggugag gcugcuggag     1020

gacggcgac                                                             1029


<210>  9
<211>  7
<212>  PRT
<213>  Simian virus 40

<400>  9

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  10
<211>  16
<212>  PRT
<213>  Simian virus 40

<400>  10

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210>  11
<211>  25
<212>  PRT
<213>  Caenorhabditis elegans

<400>  11

Met Ser Arg Arg Arg Lys Ala Asn Pro Thr Lys Leu Ser Glu Asn Ala 
1               5                   10                  15      


Lys Lys Leu Ala Lys Glu Val Glu Asn 
            20                  25  


<210>  12
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  12

Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   


<210>  13
<211>  9
<212>  PRT
<213>  Escherichia coli

<400>  13

Lys Leu Lys Ile Lys Arg Pro Val Lys 
1               5                   


<210>  14
<211>  13
<212>  DNA
<213>  Bacteriophage P1

<400>  14
ataacttcgt ata                                                          13


<210>  15
<211>  13
<212>  DNA
<213>  Bacteriophage P1

<400>  15
tatacgaagt tat                                                          13


<210>  16
<211>  8
<212>  DNA
<213>  Bacteriophage P1

<400>  16
atgtatgc                                                                 8


<210>  17
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L3 spacer sequence

<400>  17
aagtctcc                                                                 8


<210>  18
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L2 inverted spacer sequence

<400>  18
gcatacat                                                                 8


<210>  19
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LoxFas spacer sequence

<400>  19
tacctttc                                                                 8


<210>  20
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lox511 spacer sequence

<400>  20
atgtatac                                                                 8


<210>  21
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lox5171 spacer sequence

<400>  21
atgtgtac                                                                 8


<210>  22
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lox2272 spacer sequence

<400>  22
aagtatcc                                                                 8


<210>  23
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Loxm2 spacer sequence

<400>  23
agaaacca                                                                 8


<210>  24
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Loxm3 spacer sequence

<400>  24
taatacca                                                                 8


<210>  25
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Loxm7 spacer sequence

<400>  25
agatagaa                                                                 8


<210>  26
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA repeat


<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  a or g

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  c or u

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is a, c, g, or u

<400>  26
guuuuagagc unugnuguuu ug                                                22


<210>  27
<211>  5
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FokI motiv

<400>  27
ggatg                                                                    5


<210>  28
<211>  608
<212>  DNA
<213>  Human cytomegalovirus

<400>  28
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattagc atggtgatgc ggttttggca gtacatcaat gggcgtggat      420

agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt      480

tttggcacca aaatcaacgg gactttccaa aatgtcgtaa caactccgcc ccattgacgc      540

aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctccg tttagtgaac      600

gtcagatc                                                               608


<210>  29
<211>  696
<212>  DNA
<213>  Human cytomegalovirus

<400>  29
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattagc atggtgatgc ggttttggca gtacatcaat gggcgtggat      420

agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt      480

tttggcacca aaatcaacgg gactttccaa aatgtcgtaa caactccgcc ccattgacgc      540

aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctccg tttagtgaac      600

gtcagatcta gctctgggag aggagcccag cactagaagt cggcggtgtt tccattcggt      660

gatcagcact gaacacagag gaagcttgcc gccacc                                696


<210>  30
<211>  2125
<212>  DNA
<213>  Human cytomegalovirus

<400>  30
ctgcagtgaa taataaaatg tgtgtttgtc cgaaatacgc gttttgagat ttctgtcgcc       60

gactaaattc atgtcgcgcg atagtggtgt ttatcgccga tagagatggc gatattggaa      120

aaatcgatat ttgaaaatat ggcatattga aaatgtcgcc gatgtgagtt tctgtgtaac      180

tgatatcgcc atttttccaa aagtgatttt tgggcatacg cgatatctgg cgatagcgct      240

tatatcgttt acgggggatg gcgatagacg actttggtga cttgggcgat tctgtgtgtc      300

gcaaatatcg cagtttcgat ataggtgaca gacgatatga ggctatatcg ccgatagagg      360

cgacatcaag ctggcacatg gccaatgcat atcgatctat acattgaatc aatattggcc      420

attagccata ttattcattg gttatatagc ataaatcaat attggctatt ggccattgca      480

tacgttgtat ccatatcata atatgtacat ttatattggc tcatgtccaa cattaccgcc      540

atgttgacat tgattattga ctagttatta atagtaatca attacggggt cattagttca      600

tagcccatat atggagttcc gcgttacata acttacggta aatggcccgc ctggctgacc      660

gcccaacgac ccccgcccat tgacgtcaat aatgacgtat gttcccatag taacgccaat      720

agggactttc cattgacgtc aatgggtgga gtatttacgg taaactgccc acttggcagt      780

acatcaagtg tatcatatgc caagtacgcc ccctattgac gtcaatgacg gtaaatggcc      840

cgcctggcat tatgcccagt acatgacctt atgggacttt cctacttggc agtacatcta      900

cgtattagtc atcgctatta ccatggtgat gcggttttgg cagtacatca atgggcgtgg      960

atagcggttt gactcacggg gatttccaag tctccacccc attgacgtca atgggagttt     1020

gttttggcac caaaatcaac gggactttcc aaaatgtcgt aacaactccg ccccattgac     1080

gcaaatgggc ggtaggcgtg tacggtggga ggtctatata agcagagctc gtttagtgaa     1140

ccgtcagatc gcctggagac gccatccacg ctgttttgac ctccatagaa gacaccggga     1200

ccgatccagc ctccgcggcc gggaacggtg cattggaacg cggattcccc gtgccaagag     1260

tgacgtaagt accgcctata gagtctatag gcccaccccc ttggcttctt atgcatgcta     1320

tactgttttt ggcttggggt ctatacaccc ccgcttcctc atgttatagg tgatggtata     1380

gcttagccta taggtgtggg ttattgacca ttattgacca ctcccctatt ggtgacgata     1440

ctttccatta ctaatccata acatggctct ttgccacaac tctctttatt ggctatatgc     1500

caatacactg tccttcagag actgacacgg actctgtatt tttacaggat ggggtctcat     1560

ttattattta caaattcaca tatacaacac caccgtcccc agtgcccgca gtttttatta     1620

aacataacgt gggatctcca cgcgaatctc gggtacgtgt tccggacatg ggctcttctc     1680

cggtagcggc ggagcttcta catccgagcc ctgctcccat gcctccagcg actcatggtc     1740

gctcggcagc tccttgctcc taacagtgga ggccagactt aggcacagca cgatgcccac     1800

caccaccagt gtgccgcaca aggccgtggc ggtagggtat gtgtctgaaa atgagctcgg     1860

ggagcgggct tgcaccgctg acgcatttgg aagacttaag gcagcggcag aagaagatgc     1920

aggcagctga gttgttgtgt tctgataaga gtcagaggta actcccgttg cggtgctgtt     1980

aacggtggag ggcagtgtag tctgagcagt actcgttgct gccgcgcgcg ccaccagaca     2040

taatagctga cagactaaca gactgttcct ttccatgggt cttttctgca gtcaccgtcc     2100

ttgacacggt ttaaacgccg ccacc                                           2125


<210>  31
<211>  218
<212>  DNA
<213>  Bos taurus

<400>  31
ttctagttgc cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg       60

tgccactccc actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag      120

gtgtcattct attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga      180

caatagcagg catgctgggg atgcggtggg ctctatgg                              218


<210>  32
<211>  73
<212>  DNA
<213>  Homo sapiens

<400>  32
caggataata tatggtaggg ttcatagcca gagtaacctt tttttttaat ttttatttta       60

ttttattttt gag                                                          73


<210>  33
<211>  288
<212>  DNA
<213>  Simian virus 40

<400>  33
agtcagcaac caggtgtgga aagtccccag gctccccagc aggcagaagt atgcaaagca       60

tgcatctcaa ttagtcagca accatagtcc cgcccctaac tccgcccatc ccgcccctaa      120

ctccgcccag ttccgcccat tctccgcccc atggctgact aatttttttt atttatgcag      180

aggccgaggc cgcctctgcc tctgagctat tccagaagta gtgaggaggc ttttttggag      240

gcctaggctt ttgcaaaaag ctcccgggag cttgtatatc cattttcg                   288


<210>  34
<211>  129
<212>  DNA
<213>  Simian virus 40

<400>  34
aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca       60

aataaagcat ttttttcacc attctagttg tggtttgtcc aaactcatca atgtatctta      120

tcatgtctg                                                              129


<210>  35
<211>  798
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  green fluorescent protein encoding nucleic acid

<400>  35
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagtcc      720

ggactcagat ctcgagctca agcttcgaat tctgcagtcg acggtaccgc gggcccggga      780

tccaccggat ctagatga                                                    798


<210>  36
<211>  34
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  36
gaagttccta ttctctagaa agtataggaa cttc                                   34


<210>  37
<211>  13
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  37
gaagttccta ttc                                                          13


<210>  38
<211>  13
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  38
gaataggaac ttc                                                          13


<210>  39
<211>  8
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  39
tctagaaa                                                                 8


<210>  40
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  F3 site spacer sequence

<400>  40
ttcaaata                                                                 8


<210>  41
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  F5 site spacer sequence

<400>  41
ttcaaaag                                                                 8


<210>  42
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  roxP site

<400>  42
taactttaaa taatgccaat tatttaaagt ta                                     32


<210>  43
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LoxLTR site

<400>  43
acaacatcct attacaccct atatgccaac atgg                                   34


<210>  44
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LoxBTR site

<400>  44
aacccactgc ttaagcctca ataaagcttg cctt                                   34


<210>  45
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LoxV site

<400>  45
tcaatttctg agaactgtca ttctcggaaa ttga                                   34


<210>  46
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LoxFas site

<400>  46
acaacttcgt atataccttt ctatacgaag ttgt                                   34


<210>  47
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Missirlis-1 spacer sequence

<400>  47
gtatagta                                                                 8


<210>  48
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Missirlis-2 spacer sequence

<400>  48
ggctatag                                                                 8


<210>  49
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Loxm11 spacer sequence

<400>  49
tggtatcg                                                                 8


<210>  50
<211>  5
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LE inverted repeat mutant sequence

<400>  50
taccg                                                                    5


<210>  51
<211>  5
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RE inverted repeat mutant sequence

<400>  51
cggta                                                                    5


<210>  52
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lox71 site

<400>  52
taccgttcgt atagcataca ttatacgaag ttat                                   34


<210>  53
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lox66 site

<400>  53
ataacttcgt atagcataca ttatacgaac ggta                                   34


<210>  54
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LoxJTZ17 site

<400>  54
ataacttcgt atagcataca ttatagcaat ttat                                   34


<210>  55
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LoxKR1 site

<400>  55
ataacttcgt atagcataca ttataccaac tgtt                                   34


<210>  56
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LoxKR2  site

<400>  56
ataacttcgt atagcataca ttataccaac ttaa                                   34


<210>  57
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LoxKR3 site

<400>  57
ataacttcgt atagcataca ttataccttg ttat                                   34


<210>  58
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LoxKR4 site

<400>  58
ataacttcgt atagcataca ttattgcaag ttat                                   34


<210>  59
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LoxJT15 site

<400>  59
aattattcgt atagcataca ttatacgaag ttat                                   34


<210>  60
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FRT LE mutant

<400>  60
gaagttcata ttctctagaa agtataggaa cttc                                   34


<210>  61
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FRT RE mutant

<400>  61
gaagttccta ttctctagaa agtatatgaa cttc                                   34


<210>  62
<211>  201
<212>  DNA
<213>  adeno-associated virus 2

<400>  62
gggcactctt ccgtggtctg gtggataaat tcgcaagggt atcatggcgg acgaccgggg       60

ttcgaacccc ggatccggcc gtccgccgtg atccatgcgg ttaccgcccg cgtgtcgaac      120

ccaggtgtgc gacgtcagac aacgggggag cgctcctttt ggcttccttc caggcgcggc      180

ggctgctgcg ctagcttttt t                                                201


<210>  63
<211>  201
<212>  DNA
<213>  adeno-associated virus 2

<400>  63
gggcactctt ccgtggtctg gtggataaat tcgcaagggt atcatggcgg acgaccgttg       60

ttcgaacacc ggatccggcc gtccgccgtg atccatgcgg ttaccgcccg cgtgtcgaac      120

ccaggtgtgc gacgtcagac aacgggggag cgctcctttt ggcttccttc caggcgcggc      180

ggctgctgcg ctagcttttt t                                                201


<210>  64
<211>  6
<212>  DNA
<213>  adeno-associated virus 2

<400>  64
gggcac                                                                   6


<210>  65
<211>  6
<212>  DNA
<213>  Homo sapiens

<400>  65
tttttt                                                                   6


<210>  66
<211>  157
<212>  DNA
<213>  adeno-associated virus 2

<400>  66
aggagcgctc ccccgttgtc tgacgtcgca cacctgggtt cgacacgcgg gcggtaaccg       60

catggatcac ggcggacggc cggatccggt gttcgaacaa cggtcgtccg ccatgatacc      120

cttgcgaatt tatccaccag accacggaag agtgccc                               157


<210>  67
<211>  313
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VA RNA inverted sequence with Lx-LE and Lx-RE

<400>  67
taccgttcgt ataagtttat atatacgaag ttatggacga aacaccgggc acttttttca       60

gtggccaaaa aagctagcgc agcagccgcc gcgcctggaa ggaagccaaa aggagcgctc      120

ccccgttgtc tgacgtcgca cacctgggtt cgacacgcgg gcggtaaccg catggatcac      180

ggcggacggc cggatccggt gttcgaacaa cggtcgtccg ccatgatacc cttgcgaatt      240

tatccaccag accacggaag agtgcccggt gtttcgtcct accgttcgta tatataaact      300

tatacgaagt tat                                                         313


<210>  68
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  stuffer sequence

<400>  68
ggacgaaaca cc                                                           12


<210>  69
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lx-LE site with stuffer sequence

<400>  69
taccgttcgt ataagtttat atatacgaag ttatggacga aacacc                      46


<210>  70
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L3 element with mutated left inverted repeat (L3-LE)

<400>  70
taccgttcgt ataaagtctc ctatacgaag ttat                                   34


<210>  71
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L3 element with mutated right inverted repeat (L3-RE)

<400>  71
ataacttcgt ataaagtctc ctatacgaac ggta                                   34


<210>  72
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L3 element with mutated left inverted repeat (LoxFas-LE)

<400>  72
taccgttcgt atataccttt ctatacgaag ttat                                   34


<210>  73
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L3 element with mutated right inverted repeat (LoxFas-RE)

<400>  73
ataacttcgt atataccttt ctatacgaac ggta                                   34


<210>  74
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  74
tttatatat                                                                9


<210>  75
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP1 Capsid

<400>  75

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asn Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Ser Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Asn Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  76
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP1 Capsid

<400>  76

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Gln Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  77
<211>  4
<212>  RNA
<213>  Human adenovirus type 2

<400>  77
ccgg                                                                     4


<210>  78
<211>  5
<212>  RNA
<213>  Human adenovirus type 2

<400>  78
yccgg                                                                    5


<210>  79
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  VA RNA A-box consensus sequence


<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  n is a, c, g, or u

<400>  79
rrynnarygg                                                              10


<210>  80
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  VA RNA B-box consensus sequence


<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  n is a, c, g, or u

<400>  80
gwucrannc                                                                9


<210>  81
<211>  225
<212>  DNA
<213>  Human adenovirus type 2

<400>  81
cgtgcaaaag gagagcctgt aagcgggcac tcttccgtgg tctggtggat aaattcgcaa       60

gggtatcatg gcggacgacc ggggttcgaa ccccggatcc ggccgtccgc cgtgatccat      120

gcggttaccg cccgcgtgtc gaacccaggt gtgcgacgtc agacaacggg ggagcgctcc      180

ttttggcttc cttccaggcg cggcggctgc tgcgctagct ttttt                      225


<210>  82
<211>  225
<212>  DNA
<213>  Human adenovirus type 2

<400>  82
cgtgcaaaag gagagcctgt aagcgggcac tcttccgtgg tctggtggat aaattcgcaa       60

gggtatcatg gcggacgacc gttgttcgaa caccggatcc ggccgtccgc cgtgatccat      120

gcggttaccg cccgcgtgtc gaacccaggt gtgcgacgtc agacaacggg ggagcgctcc      180

ttttggcttc cttccaggcg cggcggctgc tgcgctagct ttttt                      225


<210>  83
<211>  242
<212>  DNA
<213>  Human adenovirus type 5

<400>  83
tcgttgacgc tctagaccgt gcaaaaggag agcctgtaag cgggcactct tccgtggtct       60

ggtggataaa ttcgcaaggg tatcatggcg gacgaccggg gttcgagccc cgtatccggc      120

cgtccgccgt gatccatgcg gttaccgccc gcgtgtcgaa cccaggtgtg cgacgtcaga      180

caacggggga gtgctccttt tggcttcctt ccaggcgcgg cggctgctgc gctagctttt      240

tt                                                                     242


<210>  84
<211>  466
<212>  DNA
<213>  Human adenovirus type 5

<400>  84
tcgttgacgc tctagaccgt gcaaaaggag agcctgtaag cgggcactct tccgtggtct       60

ggtggataaa ttcgcaaggg tatcatggcg gacgaccggg gttcgagccc cgtatccggc      120

cgtccgccgt gatccatgcg gttaccgccc gcgtgtcgaa cccaggtgtg cgacgtcaga      180

caacggggga gtgctccttt tggcttcctt ccaggcgcgg cggctgctgc gctagctttt      240

ttggccactg gccgcgcgca gcgtaagcgg ttaggctgga aagcgaaagc attaagtggc      300

tcgctccctg tagccggagg gttattttcc aagggttgag tcgcgggacc cccggttcga      360

gtctcggacc ggccggactg cggcgaacgg gggtttgcct ccccgtcatg caagaccccg      420

cttgcaaatt cctccggaaa cagggacgag cccctttttt gctttt                     466


<210>  85
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  52bp minimal CMV promoter

<400>  85
gtaggcgtgt acggtgggag gtctatataa gcagagctcc gtttagtgaa cg               52


<210>  86
<211>  417
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  417 bp fragment of the SV40 early promoter including the 
       transcription start (TS) region

<400>  86
atttcaggcc atggtgctgc aacctctgaa agaggaactt ggttaggttc cttctgaggc       60

ggaaagaacc agctgtggaa tgtgtgtcag ttagggtgtg gaaagtcccc aggctcccca      120

gcaggcagaa gtatgcaaag catgcatctc aattagtcag caaccaggtg tggaaagtcc      180

ccaggctccc cagcaggcag aagtatgcaa agcatgcatc tcaattagtc agcaaccata      240

gtcccgcccc taactccgcc catcccgccc ctaactccgc ccagttccgc ccattctccg      300

ccccatggct gactaatttt ttttatttat gcagaggccg aggccgcctc ggcctctgag      360

ctattccaga agtagtgagg aggctttttt ggaggactag gcttttgcaa aaagcta         417


<210>  87
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mCherry

<400>  87

Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe 
1               5                   10                  15      


Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe 
            20                  25                  30          


Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr 
        35                  40                  45              


Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp 
    50                  55                  60                  


Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His 
65                  70                  75                  80  


Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe 
                85                  90                  95      


Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val 
            100                 105                 110         


Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys 
        115                 120                 125             


Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly 
145                 150                 155                 160 


Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly 
                165                 170                 175     


His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val 
            180                 185                 190         


Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser 
        195                 200                 205             


His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly 
    210                 215                 220                 


Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235     


<210>  88
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFP

<400>  88

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210>  89
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FRT-LE-RE

<400>  89
gaagttcata ttctctagaa agtatatgaa cttc                                   34


