               SEQUENCE LISTING

<110> COMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

<120> Anti-LILRB antibodies and uses thereof

<130> PR91005

<150> EP20306197
<151> 2020-10-12

<160> 27

<170> BiSSAP 1.3.6

<210> 1
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> B1.2.1. - H-CDR1

<400> 1
Gly Phe Thr Phe Asn Thr His Ala 
1               5               

<210> 2
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> B1.2.1. - H-CDR2

<400> 2
Ile Arg Ser Lys Ser Ser Asn Tyr Ala Thr 
1               5                   10  

<210> 3
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> B1.2.1. - H-CDR3

<400> 3
Val Met Val Tyr Tyr Gly Asn Ser Pro Tyr Tyr Ser Met Asp Tyr 
1               5                   10                  15  

<210> 4
<211> 124
<212> PRT
<213> Artificial Sequence


<220> 
<223> B1.2.1. - VH

<400> 4
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr His 
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Arg Ser Lys Ser Ser Asn Tyr Ala Thr Phe Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      
Phe Cys Val Met Val Tyr Tyr Gly Asn Ser Pro Tyr Tyr Ser Met Asp 
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 

<210> 5
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> B1.2.1. - L-CDR1

<400> 5
Glu Asn Val Gly Thr Tyr 
1               5       

<210> 6
<211> 3
<212> PRT
<213> Artificial Sequence


<220> 
<223> B1.2.1. - L-CDR2

<400> 6
Gly Ala Ser 
1           

<210> 7
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> B1.2.1. - L-CDR3

<400> 7
Gly Gln Ser Tyr Ser Ser Pro Leu Thr 
1               5                   

<210> 8
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> B1.2.1. - VL

<400> 8
Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      
Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Glu Asn Val Gly Thr Tyr 
            20                  25                  30          
Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  
Ser Gly Ser Ala Thr Asp Phe Thr Leu Ile Ile Asn Asn Ile Gln Ala 
65                  70                  75                  80  
Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Ser Tyr Ser Ser Pro Leu 
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         

<210> 9
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> B1.2.2. - H-CDR1

<400> 9
Gly Phe Thr Phe Ser Asp Tyr Gly 
1               5               

<210> 10
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> B1.2.2. - H-CDR2

<400> 10
Ile Ser Ser Gly Ser Ser Thr Ser 
1               5               

<210> 11
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> B1.2.2. - H-CDR3

<400> 11
Ala Arg Pro Gly Ser Asn Trp Asp Val Tyr Tyr Ala Met Asp Tyr 
1               5                   10                  15  

<210> 12
<211> 122
<212> PRT
<213> Artificial Sequence


<220> 
<223> B1.2.2. - VH

<400> 12
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ser Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  
Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Pro Gly Ser Asn Trp Asp Val Tyr Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         

<210> 13
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> B12.2. - L-CDR1

<400> 13
Gln Ser Val Ser Thr Ser Ser Tyr Ser Tyr 
1               5                   10  

<210> 14
<211> 3
<212> PRT
<213> Artificial Sequence


<220> 
<223> B1.2.2. - L-CDR2

<400> 14
Asn Ala Ser 
1           

<210> 15
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> B1.2.2. - L-CDR-3

<400> 15
Gln His Ser Trp Glu Ile Pro Phe Thr 
1               5                   

<210> 16
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> B1.2.2. - VL

<400> 16
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser 
            20                  25                  30          
Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Lys Asn Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  
Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      
Glu Ile Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     

<210> 17
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Flag sequence

<400> 17
Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               

<210> 18
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> Signal peptide

<400> 18
Met Ser Ala Leu Leu Ile Leu Ala Leu Val Gly Ala Ala Val Ala 
1               5                   10                  15  

<210> 19
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> MHC-I A*2402 HIV-1 Nef 134-143

<400> 19
Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr 
1               5                   10  

<210> 20
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> MHC-I B*0801 HIV-1 Gag 259-267

<400> 20
Gly Glu Ile Tyr Lys Arg Trp Ile Ile 
1               5                   

<210> 21
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> cynomolgus macaque Mafa-A1*063 SIV gag GW9

<400> 21
Gly Pro Arg Lys Pro Ile Lys Cys Trp 
1               5                   

<210> 22
<211> 122
<212> PRT
<213> Artificial Sequence


<220> 
<223> B1.2.2.-311-VHA

<400> 22
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Ser Tyr 
            20                  25                  30          
Gly Met His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ser Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Pro Gly Ser Asn Trp Asp Val Tyr Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         

<210> 23
<211> 122
<212> PRT
<213> Artificial Sequence


<220> 
<223> B1.2.2.-330-VHA

<400> 23
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ser Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Pro Gly Ser Asn Trp Asp Val Tyr Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         

<210> 24
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> B1.2.2.-41-VLA

<400> 24
Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Gln Ser Val Ser Thr Ser 
            20                  25                  30          
Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Lys Asn Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  
Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      
Glu Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110     

<210> 25
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> B1.2.2.-139-VLA

<400> 25
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Thr Ser 
            20                  25                  30          
Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              
Lys Leu Leu Ile Lys Asn Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  
Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      
Glu Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110     

<210> 26
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> B1.2.2.-311-VLA

<400> 26
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser 
            20                  25                  30          
Ser Tyr Ser Tyr Met His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              
Gln Leu Leu Ile Lys Asn Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  
Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      
Glu Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110     

<210> 27
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> B1.2.2.-228-VLA

<400> 27
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser 
            20                  25                  30          
Ser Tyr Ser Tyr Met His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              
Gln Leu Leu Ile Lys Asn Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  
Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      
Glu Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110     

