                         SEQUENCE LISTING

<110>  Eberhard-Karls-Universitt Tbingen
 
<120>  Artificial Nucleic Acids for RNA Editing

<130>  UT03P006WO1

<160>  94    

<170>  PatentIn version 3.5

<210>  1
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence.


<220>
<221>  Luciferase_W417X_RG-V21_0xRS_20p8
<222>  (1)..(75)
<223>  Used in figure #1 & #7

<400>  1
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgtgca       60

gccagccgtc cttgt                                                        75


<210>  2
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  Luciferase_W417X_RG-V21_3xRS(15-13-11-20p8)_3xA
<222>  (1)..(123)
<223>  Used in figure #1, #2, #3, #4, #6, #7, #8, #9, #13

<400>  2
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgtgca       60

gccagccgtc cttgtaaacg cacagctcga aagtccaagt ccaccaaaaa gaagggcacc      120

acc                                                                    123


<210>  3
<211>  206
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  Luciferase_W417X_RG-V21_8xRS(11-15-15-15-12-15-13-11-20p8)_3xA
<222>  (1)..(206)
<223>  Used in figure #1, #6, #7

<400>  3
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgtgca       60

gccagccgtc cttgtaaacg cacagctcga aagtccaagt ccaccaaaaa gaagggcacc      120

accaaactcc tcctcgaaaa aaaagccgca gatcaaaaac gaagctctcg aaaccacagc      180

cacaccgaaa acacaccacg atccga                                           206


<210>  4
<211>  95
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V20 motif, targeting sequence.


<220>
<221>  Luciferase_W417X_RG-V20_0xRS_16p8_BoxB
<222>  (1)..(95)
<223>  Used in figure #2

<400>  4
gtggtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg accacgtgca       60

gccagccgtc ctctagaggg ccctgaagag ggccc                                  95


<210>  5
<211>  223
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  AHI_W725X_RG-V21_9xRS_20p8
<222>  (1)..(223)

<220>
<221>  AHI_W725X_RG-V21_9xRS_20p8
<222>  (1)..(223)
<223>  Used in figure #5

<400>  5
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccaactt       60

tccatatccg tatcaaaaaa acaaaagaag gaaaaaaacg tccagaagaa agagaaatca      120

agaaaagaag agccatcaaa acctcaacaa cacaaaaaga aatcaagaat aaacctcgaa      180

gcaaaaaaga aacaggccgt ccacaaaggt catcatcaag caa                        223


<210>  6
<211>  225
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  BMPR2_W298X_RG-V21_9xRS_20p8
<222>  (1)..(225)
<223>  Used in figure #5

<400>  6
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgctta       60

cccagtcact tgtgtaaaac tccatcacaa aaactctctc atctccaaca aatccatcaa      120

aggcactcaa agcaaaggaa aacacaaaga cgctcatcca agaaaacctc ggccaatcag      180

aaaatcaaaa cagcaaaaac agcagaaacg aaaagaccaa catcc                      225


<210>  7
<211>  225
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  COL3A1_W1278X_RG-V21_9xRS_20p8
<222>  (1)..(225)
<223>  Used in figure #5

<400>  7
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgtcaa       60

cccagtattc tccacaaaag aaccatcaga aagggcaaaa ccgcaaaacc tccaatccca      120

gcaaaacaac accaccacag caaaaccctc agatcctcaa aggtccaaca ggtcctcaaa      180

cagcagctcc acgaaaggcc agcagggcca caaacaccac gatca                      225


<210>  8
<211>  225
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  FANCC_W506X_RG-V21_9xRS_20p8
<222>  (1)..(225)
<223>  Used in figure #5

<400>  8
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgacat       60

cccaggcgat cgtgtaaagc ctcccatcac aaatctcagc ccatcctcca aagaaccagc      120

tctcaaagaa acaaaccgca gcaaatccag ggccccatcg aaactcatca acaacccgga      180

aagccgaagc cagaaaacct caaagaactc aaaggacaca aactc                      225


<210>  9
<211>  211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  MYBPC3_W1098X_RG-V21_9xRS_20p8
<222>  (1)..(211)
<223>  Used in figure #5

<400>  9
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgtacc       60

cccagagctc cgtgtaaatc cactccagaa aacgtcagtc acccgaaagc accgtcacca      120

aatcacctcc tcgaaatcac aggctccccg acaaagaaaa gcagccgaaa cagccaccca      180

ctaaatccca cgcgctaaaa gacgcgcatc t                                     211


<210>  10
<211>  173
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  IL2RG_W237X_RG-V21_6xRS_20p8
<222>  (1)..(173)
<223>  Used in figure #5

<400>  10
gggagtgggg ctgtttgtgt tttgtgttct ttcttctggc tgttttcgga ctgactggga       60

ctttgtgtgg atgggctttg tttcgtgttc ggagctttgt gctcagcatt ggagtgaagg      120

tgtcgaggag acgagaacaa catttagcat attgttctcc tcttctcgac acc             173


<210>  11
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  PINK1_W437X_RG-V21_3xRS_20p8
<222>  (1)..(123)
<223>  Used in figure #5

<400>  11
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acacccactg       60

cccaggcatc agcctaaacc gccccgatcc acgaaatctc atcagccaga aaatcaccag      120

cca                                                                    123


<210>  12
<211>  89
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  Luciferase_W417X_RG-V21_1xRS_20p8
<222>  (1)..(89)
<223>  Used in figure #7

<400>  12
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgtgca       60

gccagccgtc cttgtaaacg cacagctcg                                         89


<210>  13
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  Luciferase_W417X_RG-V21_2xRS_20p8
<222>  (1)..(105)
<223>  Used in figure #7

<400>  13
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgtgca       60

gccagccgtc cttgtaaacg cacagctcga aagtccaagt ccacc                      105


<210>  14
<211>  170
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  Luciferase_W417X_RG-V21_6xRS_20p8
<222>  (1)..(170)
<223>  Used in figure #7

<400>  14
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgtgca       60

gccagccgtc cttgtaaacg cacagctcga aagtccaagt ccaccaaaaa gaagggcacc      120

accaaactcc tcctcgaaaa aaaagccgca gatcaaaaac gaagctctcg                 170


<210>  15
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  Luciferase_W417X_RG-V21_20xRS_20p8
<222>  (1)..(384)
<223>  Used in figure #7

<400>  15
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgtgca       60

gccagccgtc cttgtaaacg cacagctcga aagtccaagt ccaccaaaaa gaagggcacc      120

accaaactcc tcctcgaaaa aaaagccgca gatcaaaaac gaagctctcg aaaccacagc      180

cacaccgaaa acacaccacg atccgaaaag aacgctcatc tcaaactcgc cggcggtccc      240

aaactcctcc acgtctccaa aatcaacgaa cgaaaagaaa agaatccaaa acaacgtcag      300

gaaatctcca aaaccaaaat caatcacatc aaacacccca atcaaaaaca ccgcgcaaag      360

aatcaagaac aaaagcccac cact                                             384


<210>  16
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  Luciferase_W417X_RG-V21_3xRS(7-7-7-20p8)
<222>  (1)..(105)
<223>  Used in figure #7

<220>
<221>  Luciferase_W417X_RG-V21_3xRS(7-7-7-20p8)
<222>  (1)..(105)
<223>  Used in figure #8

<400>  16
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgtgca       60

gccagccgtc cttgtaaacc tcgggaaaaa gtccaaaaga agaag                      105


<210>  17
<211>  111
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  Luciferase_W417X_RG-V21_3xRS(9-9-9-20p8)
<222>  (1)..(111)
<223>  Used in figure #8

<400>  17
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgtgca       60

gccagccgtc cttgtaaaac gcacagcaaa cacacccaga aatccaccac c               111


<210>  18
<211>  117
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  Luciferase_W417X_RG-V21_3xRS(11-11-11-20p8)
<222>  (1)..(117)
<223>  Used in figure #8

<400>  18
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgtgca       60

gccagccgtc cttgtaaacg cacagctcga aacaagtcca ccaaaaaggg caccacc         117


<210>  19
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  Luciferase_W417X_RG-V21_3xRS(13-13-13-20p8)
<222>  (1)..(123)
<223>  Used in figure #8

<400>  19
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgtgca       60

gccagccgtc cttgtaaaac ggacgcacag caaaccaagt ccaccacaaa agaagggcac      120

cac                                                                    123


<210>  20
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  Luciferase_W417X_RG-V21_3xRS(15-S-15-S-15-S-20p8)
<222>  (1)..(129)
<223>  Used in figure #8, #10, #11, #18

<400>  20
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgtgca       60

gccagccgtc cttgtaaaac gcacagctcg ccgaaagtcc aagtccacca caaaaagaag      120

ggcaccacc                                                              129


<210>  21
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  Luciferase_W417X_RG-V21_3xRS(15-13-11-20p8)_0xA
<222>  (1)..(114)
<223>  Used in figure #9

<400>  21
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgtgca       60

gccagccgtc cttgtcgcac agctcggtcc aagtccacca agaagggcac cacc            114


<210>  22
<211>  117
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  Luciferase_W417X_RG-V21_3xRS(15-13-11-20p8)_1xA
<222>  (1)..(117)
<223>  Used in figure #9

<400>  22
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgtgca       60

gccagccgtc cttgtacgca cagctcgagt ccaagtccac caaagaaggg caccacc         117


<210>  23
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  Luciferase_W417X_RG-V21_3xRS(15-13-11-20p8)_2xA
<222>  (1)..(120)
<223>  Used in figure #9

<400>  23
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgtgca       60

gccagccgtc cttgtaacgc acagctcgaa gtccaagtcc accaaaagaa gggcaccacc      120


<210>  24
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  Luciferase_W417X_RG-V21_3xRS(15-13-11-20p8)_4xA
<222>  (1)..(126)
<223>  Used in figure #9

<400>  24
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgtgca       60

gccagccgtc cttgtaaaac gcacagctcg aaaagtccaa gtccaccaaa aaagaagggc      120

accacc                                                                 126


<210>  25
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  Luciferase_W417X_RG-V21_3xRS(15-13-11-20p8)_5xA
<222>  (1)..(129)
<223>  Used in figure #9

<400>  25
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgtgca       60

gccagccgtc cttgtaaaaa cgcacagctc gaaaaagtcc aagtccacca aaaaaagaag      120

ggcaccacc                                                              129


<210>  26
<211>  143
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  Luciferase_W417X_RG-V21_3xRS(15-13-11-20p8)_10xA
<222>  (1)..(143)
<223>  Used in figure #9

<400>  26
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgtgca       60

gccagccgtc cttgtaaaaa aaaaacgcac agctcgaaaa aaaaaagtcc aagtccacca      120

aaaaaaaaaa agaagggcac cac                                              143


<210>  27
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  Luciferase_W417X_RG-V21_3xRS(15-L-15-S-15-S-20p8)
<222>  (1)..(129)
<223>  Used in figure #10

<400>  27
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgtgca       60

gccagccgtc cttgtaaaac gcacagctcg ccgaaagtcc aagtccacca caaacgaaag      120

ccgcagatc                                                              129


<210>  28
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  Luciferase_W417X_RG-V21_3xRS(15-L-15-L-15-S-20p8)
<222>  (1)..(129)
<223>  Used in figure #10

<400>  28
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgtgca       60

gccagccgtc cttgtaaaac gcacagctcg ccgaaacgaa agccgcagat caaaccacag      120

ccacaccga                                                              129


<210>  29
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  Luciferase_W417X_RG-V21_3xRS(15-S-15-L-15-S-20p8)
<222>  (1)..(129)
<223>  Used in figure #10

<400>  29
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgtgca       60

gccagccgtc cttgtaaaac gcacagctcg ccgaaacgaa agccgcagat caaagaacat      120

gccgaagcc                                                              129


<210>  30
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  Luciferase_W417X_RG-V21_3xRS(15-S-15-S-15-L-20p8)
<222>  (1)..(129)
<223>  Used in figure #10

<400>  30
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgtgca       60

gccagccgtc cttgtaaacg aaagccgcag atcaaagaac atgccgaagc caaaatgggg      120

tcgcgggca                                                              129


<210>  31
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  Luciferase_W417X_RG-V21_3xRS(15-S-15-L-15-L-20p8)
<222>  (1)..(129)
<223>  Used in figure #10

<400>  31
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgtgca       60

gccagccgtc cttgtaaacg aaagccgcag atcaaaccac agccacaccg aaaacaccca      120

acacgggca                                                              129


<210>  32
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  Luciferase_W417X_RG-V21_3xRS(15-L-15-S-15-L-20p8)
<222>  (1)..(129)
<223>  Used in figure #10

<400>  32
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgtgca       60

gccagccgtc cttgtaaacg aaagccgcag atcaaagaac atgccgaagc caaacaccca      120

acacgggca                                                              129


<210>  33
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  Luciferase_W417X_RG-V21_3xRS(15-L-15-L-15-L-20p8)
<222>  (1)..(129)
<223>  Used in figure #10, #11

<400>  33
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgtgca       60

gccagccgtc cttgtaaacg aaagccgcag atcaaaccac agccacaccg aaaactcgct      120

caacgaacg                                                              129


<210>  34
<211>  134
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  Luciferase_W417X_RG-V21_3xRS(20-S-15-S-15-S-20p8)
<222>  (1)..(134)
<223>  Used in figure #11, #14

<400>  34
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgtgca       60

gccagccgtc cttgtaaaac gcacagctcg ccgaaagtcc aagtccacca caaacctcga      120

agaagggcac cacc                                                        134


<210>  35
<211>  134
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  Luciferase_W417X_RG-V21_3xRS(15-S-20-S-15-S-20p8)
<222>  (1)..(134)
<223>  Used in figure #11

<400>  35
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgtgca       60

gccagccgtc cttgtaaaac gcacagctcg ccgaaaccgg tgtccaagtc caccacaaaa      120

agaagggcac cacc                                                        134


<210>  36
<211>  134
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  Luciferase_W417X_RG-V21_3xRS(15-S-15-S-20-S-20p8)
<222>  (1)..(134)
<223>  Used in figure #11

<400>  36
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgtgca       60

gccagccgtc cttgtaaaca cggacgcaca gctcgccgaa agtccaagtc caccacaaaa      120

agaagggcac cacc                                                        134


<210>  37
<211>  134
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  Luciferase_W417X_RG-V21_3xRS(20-L-15-L-15-L-20p8)
<222>  (1)..(134)
<223>  Used in figure #11

<400>  37
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgtgca       60

gccagccgtc cttgtaaacg aaagccgcag atcaaaccac agccacaccg aaaagagaac      120

tcgctcaacg aacg                                                        134


<210>  38
<211>  134
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  Luciferase_W417X_RG-V21_3xRS(15-L-20-L-15-L-20p8)
<222>  (1)..(134)
<223>  Used in figure #11

<400>  38
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgtgca       60

gccagccgtc cttgtaaacg aaagccgcag atcaaagggg ccacagccac accgataaac      120

tcgctcaacg aacg                                                        134


<210>  39
<211>  134
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  Luciferase_W417X_RG-V21_3xRS(15-L-15-L-20-L-20p8)
<222>  (1)..(134)
<223>  Used in figure #11

<400>  39
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgtgca       60

gccagccgtc cttgtaaacg acccgaaagc cgcagatcaa accacagcca caccgaaaac      120

tcgctcaacg aacg                                                        134


<210>  40
<211>  171
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  Luciferase_W417X_RG-V21_3xRS(RS#1-3mask_15-13-11-20p8)
<222>  (1)..(171)
<223>  Used in figure #13

<400>  40
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgtgca       60

gccagccgtc cttgtaaacg cacagctcga aagtccaagt ccaccaaaaa gaagggcacc      120

accaaaggtg gtgcccttct taaaggtgga cttggacaaa cgagctgtgc g               171


<210>  41
<211>  141
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  Luciferase_W417X_RG-V21_3xRS(RS#3mask_15-13-11-20p8)
<222>  (1)..(141)
<223>  Used in figure #13

<400>  41
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgtgca       60

gccagccgtc cttgtaaacg cacagctcga aagtccaagt ccaccaaaaa gaagggcacc      120

accaaaggtg gtgcccttct t                                                141


<210>  42
<211>  157
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  Luciferase_W417X_RG-V21_3xRS(RS#2+3mask_15-13-11-20p8)
<222>  (1)..(157)
<223>  Used in figure #13

<400>  42
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgtgca       60

gccagccgtc cttgtaaacg cacagctcga aagtccaagt ccaccaaaaa gaagggcacc      120

accaaaggtg gtgcccttct taaaggtgga cttggac                               157


<210>  43
<211>  134
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  RAB7A_3'UTR_TAG#1_RG-V21_3xRS(20-15-15-20p8)_3xA
<222>  (1)..(134)
<223>  Used in figure #15, #17

<400>  43
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccctgcc       60

gccagctgga tttccaaatt caaccctcca cctaaataca aaactcagcc taaataaaaa      120

gaccacaaga ccaa                                                        134


<210>  44
<211>  127
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  RAB7A_3'UTR_TAG#1_RG-V21_3xRS(19-13-11-20p8)_3xA
<222>  (1)..(127)
<223>  Used in figure #15, #17, #20, #21

<400>  44
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccctgcc       60

gccagctgga tttccaaatc aaccctccac caaaacaaaa ctcagaaaaa aaagaccaca      120

agaccaa                                                                127


<210>  45
<211>  134
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  Beta-Actin_3'UTR_TAG#1_RG-V21_3xRS(20-15-15-20p8)_3xA
<222>  (1)..(134)
<223>  Used in figure #15

<400>  45
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccacgca       60

accaagtcat agtccaaagg aggggccgga ctcaaaccgc cgatccacac gaaatgcgct      120

caggaggagc aatg                                                        134


<210>  46
<211>  144
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  Beta-Actin_3'UTR_TAG#1_RG-V21_3xRS(20-20-20-20p8)_3xA
<222>  (1)..(144)
<223>  Used in figure #15

<400>  46
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccacgca       60

accaagtcat agtccaaaag ccgccgatcc acacggagaa acctcagggc agcggaaccg      120

caaagctcga agtccagggc gacg                                             144


<210>  47
<211>  134
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  GAPDH_3'UTR_TAG#1_RG-V21_3xRS(20-15-15-20p8)_3xA
<222>  (1)..(134)
<223>  Used in figure #15

<400>  47
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccagggg       60

tccacatggc aactgaaaca gggactcccc agcaaagaag tcagaggaga caaatagacg      120

gcaggtcagg tcca                                                        134


<210>  48
<211>  144
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  GAPDH_3'UTR_TAG#1_RG-V21_3xRS(20-20-20-20p8)_3xA
<222>  (1)..(144)
<223>  Used in figure #15

<400>  48
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccagggg       60

tccacatggc aactgaaatg tggcagggac tccccagcaa agaagtcaga ggagaccacc      120

taaatagacg gcaggtcagg tcca                                             144


<210>  49
<211>  134
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  NUP43_V223V_RG-V21_3xRS(20-15-15-20p8)_3xA
<222>  (1)..(134)
<223>  Used in figure #16, #17

<400>  49
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acacccagtg       60

gccacaacat gctgtaaacg gtcaccagtc agtaaaaacc ctccatcaga gaaaaggcag      120

cggtcgccag cggg                                                        134


<210>  50
<211>  144
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  NUP43_V223V_RG-V21_3xRS(20-20-20-20p8)_3xA
<222>  (1)..(144)
<223>  Used in figure #16, #17

<400>  50
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acacccagtg       60

gccacaacat gctgtaaagg cactcggtca ccagtcagaa aaaaccctcc atcagagtcc      120

aaaaaggcag cggtcgccag cggg                                             144


<210>  51
<211>  134
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  GusB_L456L_RG-V21_3xRS(20-15-15-20p8)_3xA
<222>  (1)..(134)
<223>  Used in figure #16

<400>  51
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acacccagat       60

tccaggtggg acgcaaaaag accacatcac gacaaacacg ccgggacact caaagcacca      120

agccagcgaa gcag                                                        134


<210>  52
<211>  144
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  GusB_L456L_RG-V21_3xRS(20-20-20-20p8)_3xA
<222>  (1)..(144)
<223>  Used in figure #16

<400>  52
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acacccagat       60

tccaggtggg acgcaaaagc cacagaccac atcacgacaa acacgccggg acactcatcg      120

aaaagcacca agccagcgaa gcag                                             144


<210>  53
<211>  132
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  GAPDH_L157L_RG-V21_3xRS(18-15-15-20p8)_3xA
<222>  (1)..(132)
<223>  Used in figure #16

<400>  53
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccggggt       60

gccaagcagt tggtgaaagg ggcatcagca gagaaagcgc cagcatcgcc caaatggagg      120

gatctcgctc ct                                                          132


<210>  54
<211>  144
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  GAPDH_L157L_RG-V21_3xRS(20-20-20-20p8)_3xA
<222>  (1)..(144)
<223>  Used in figure #16

<400>  54
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccggggt       60

gccaagcagt tggtgaaagg gggcatcagc agagggggaa aactcagcgc cagcatcgcc      120

caaacgaaca ggaggagcag agag                                             144


<210>  55
<211>  133
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  PAICS_V269_RG-V21_3xRS(19-15-15-20p8)_3xA
<222>  (1)..(133)
<223>  Used in figure #16

<400>  55
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acacctcaac       60

accacaaccc tgcacaaagc aacccactca aagaaaagtc tccaggaatc aaaataacat      120

cagcaagaac aat                                                         133


<210>  56
<211>  144
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  PAICS_V269V_RG-V21_3xRS(20-20-20-20p8)_3xA
<222>  (1)..(144)
<223>  Used in figure #16

<400>  56
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acacctcaac       60

accacaaccc tgcacaaagg ccagagtctc caggaatcaa aagaagtcca gcaaagcaaa      120

aaaaccgcgc cgggaagcga ggca                                             144


<210>  57
<211>  134
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  GPI_V627V_RG-V21_3xRS(20-15-15-20p8)_3xA
<222>  (1)..(134)
<223>  Used in figure #16

<400>  57
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acacctgccg       60

tccaccagga tgggtaaaca cggctcgacc ctcaaagaac atccgctccc gaaacgcatc      120

acgtcctccg tcac                                                        134


<210>  58
<211>  144
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  GPI_V627V_RG-V21_3xRS(20-20-20-20p8)_3xA
<222>  (1)..(144)
<223>  Used in figure #16

<400>  58
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acacctgccg       60

tccaccagga tgggtaaagc agcacggctc gaccctcgaa accgggcggc ctccacgccc      120

caaaatcacg tcctccgtca ccag                                             144


<210>  59
<211>  133
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  PDE4D_L291L_RG-V21_3xRS(19-15-15-20p8)_3xA
<222>  (1)..(133)
<223>  Used in figure #16

<400>  59
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgggtc       60

tccagctggt ccagaaaagc tcctccaggg tctaaaaatc aagtcatctc caaatgtcca      120

catcaaaacg cct                                                         133


<210>  60
<211>  144
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  PDE4D_L291L_RG-V21_3xRS(20-20-20-20p8)_3xA
<222>  (1)..(144)
<223>  Used in figure #16

<400>  60
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccgggtc       60

tccagctggt ccagaaaaca gctcctccag ggtctcgcaa atcacaatca agtcatctcc      120

gaaaaaggga ctccgtcccg caga                                             144


<210>  61
<211>  111
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Simple and unstructured LEAPER gRNA that is reverse complementary
       to the target mRNA, but contains a C-A mismatch at the target 
       site.


<220>
<221>  RAB7A_3'UTR_TAG#1_111p56_LEAPER
<222>  (1)..(111)
<223>  Used in figure #17, #20, #21

<400>  61
gtctttgata aaaggcgtac ataattcttg tgtctactgt acagaatact gccgccagct       60

ggatttccca attctgagta acactctgca atccaaacag ggttcaaccc t               111


<210>  62
<211>  111
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Simple and unstructured LEAPER gRNA that is reverse complementary
       to the target mRNA, but contains a C-A mismatch at the target 
       site.


<220>
<221>  RAB7A_3'UTR_TAG#1_111p56_LEAPER_AG20
<222>  (1)..(111)
<223>  Used in figure #17

<400>  62
gtctttgaga aaaggcggac agaagtctgg tgtcgacggg acagaagacg gccgccagct       60

ggagggccca aggcggagga acactcggca atccaaacag ggggcaaccc t               111


<210>  63
<211>  111
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Simple and unstructured LEAPER gRNA that is reverse complementary
       to the target mRNA, but contains a C-A mismatch at the target 
       site.


<220>
<221>  NUP43_V233V_111p56_LEAPER
<222>  (1)..(111)
<223>  Used in figure #17

<400>  63
tagtaccttg tctaacatcc caaatactca acattccatc ttggccacca gtagccacaa       60

catgctgttg gttgggatgt ctatcaacac agtggagtgg cactcggtca c               111


<210>  64
<211>  111
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Simple and unstructured LEAPER gRNA that is reverse complementary
       to the target mRNA, but contains a C-A mismatch at the target 
       site.


<220>
<221>  NUP43_V233V_111p56_LEAPER_AG6
<222>  (1)..(111)
<223>  Used in figure #17

<400>  64
tagtaccttg tctaacatcc caaagactca acattccatc gtggccacca ggagccacaa       60

catgctggtg ggtgggatgt cgatcaacac agtggagtgg cactcggtca c               111


<210>  65
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  NUP43_V223V_RG-V21_3xRS(15-15-15-20p8)_3xA_Placement_C
<222>  (1)..(129)
<223>  Used in figure #12

<400>  65
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acacccagta       60

gccacaacat gctgtaaaac caaccccgtc aagaaaaatc agggatctcc caaattacaa      120

atcaacact                                                              129


<210>  66
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  NUP43_V223V_RG-V21_3xRS(15-15-15-20p8)_3xA_Placement_D
<222>  (1)..(129)
<223>  Used in figure #12

<400>  66
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acacccagta       60

gccacaacat gctgtaaagg gctcaaaaga gccaaattct caccgcagat aaaactcagc      120

caagaaaca                                                              129


<210>  67
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  NUP43_V223V_RG-V21_3xRS(15-15-15-20p8)_3xA_Placement_E
<222>  (1)..(129)
<223>  Used in figure #12

<400>  67
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acacccagta       60

gccacaacat gctgtaaaga cgtcaaaatc aaaaaattcc caagaaaatc taaattcaaa      120

ggcaactct                                                              129


<210>  68
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  NUP43_V223V_RG-V21_3xRS(15-15-15-20p8)_3xA_Placement_F
<222>  (1)..(129)
<223>  Used in figure #12

<400>  68
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acacccagta       60

gccacaacat gctgtaaaac caaccccgtc aagaaaccac cacacccagc caaaaggcag      120

gagaatcac                                                              129


<210>  69
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  NUP43_V223V_RG-V21_3xRS(15-15-15-20p8)_3xA_Placement_G
<222>  (1)..(129)
<223>  Used in figure #12

<400>  69
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acacccagta       60

gccacaacat gctgtaaact cagccaagaa acaaaaaaca aaacacacac aaaacagaga      120

tcgcaccac                                                              129


<210>  70
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  NUP43_V223V_RG-V21_3xRS(15-15-15-20p8)_3xA_Placement_H
<222>  (1)..(129)
<223>  Used in figure #12

<400>  70
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acacccagta       60

gccacaacat gctgtaaatc accagtcagt gacaaattgt ctatggttct taaaagagtc      120

tggttattt                                                              129


<210>  71
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  NUP43_V223V_RG-V21_3xRS(15-15-15-20p8)_3xA_Placement_B
<222>  (1)..(129)
<223>  Used in figure #12

<400>  71
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acacccagta       60

gccacaacat gctgtaaaga cgtcaaaatc aaaaaaaaca caggaaacac gaaagagaca      120

aggcctcac                                                              129


<210>  72
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  NUP43_V223V_RG-V21_3xRS(15-15-15-20p8)_3xA_Placement_A
<222>  (1)..(129)
<223>  Used in figure #12

<400>  72
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acacccagta       60

gccacaacat gctgtaaaac catcctctcc aacaaaaaac cctccatcag aaaacgaaag      120

cggccgcag                                                              129


<210>  73
<211>  221
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  hIDUA_W402X_RG-V21_9xRS_3xA
<222>  (1)..(221)

<400>  73
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccttcgg       60

cccagagctg ctcctaaact caggaaggca aaagtcacgt ccgccctcca aaaccagccc      120

accagcgaaa cgcccgcctc cccagaaatc ccagccgcaa aacagaccct ccgagaaagg      180

agaccaagtc caaatcctca aagtcagaaa acaagctcca g                          221


<210>  74
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  hIDUA_W402X_RG-V21_3xRS(15-15-15-20p8)_3xA_Version #1
<222>  (1)..(129)

<400>  74
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccttcgg       60

cccagagctg ctcctaaaac gtccgccctc cacaaaccag ccgcacgccc gaaagcgcgc      120

agaccctcc                                                              129


<210>  75
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  hIDUA_W402X_RG-V21_4xRS(15-15-15-15-20p8)_3xA_Version #2
<222>  (1)..(147)

<400>  75
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccttcgg       60

cccagagctg ctcctaaaac gtccgccctc cacaaaccag ccgcacgccc gaaactccca      120

gccgcaggga aagcgcgcag accctcc                                          147


<210>  76
<211>  134
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  hIDUA_W402X_RG-V21_3xRS(20-15-15-20p8)_3xA_Version #3
<222>  (1)..(134)

<400>  76
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccttcgg       60

cccagagctg ctcctaaagc gccagcagcc ccaaaaagct caggaaggca taaaaccagc      120

gggtccgcct cgtc                                                        134


<210>  77
<211>  134
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  hIDUA_W402X_RG-V21_3xRS(20-15-15-20p8)_3xA_Version #4
<222>  (1)..(134)

<400>  77
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccttcgg       60

cccagagctg ctcctaaagc gccagcagcc ccaaaagacc agcccaccag caaaccgcac      120

gcccgcctcc ccag                                                        134


<210>  78
<211>  134
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  hIDUA_W402X_RG-V21_3xRS(20-15-15-20p8)_3xA_Version #5
<222>  (1)..(134)

<400>  78
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccttcgg       60

cccagagctg ctcctaaaac gtccgccctc cacaaaccag ccgcacgccc gaaagaccct      120

ccgagcaggc atcg                                                        134


<210>  79
<211>  152
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  hIDUA_W402X_RG-V21_4xRS(20-15-15-15-20p8)_3xA_Version #6
<222>  (1)..(152)

<400>  79
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccttcgg       60

cccagagctg ctcctaaagc gccagcagcc ccaaaatccg ccctccacgg caaagaccag      120

cccaccagca aaccgcacgc ccgcctcccc ag                                    152


<210>  80
<211>  144
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  hIDUA_W402X_RG-V21_3xRS(20-20-20-20p8)_3xA_Version #7
<222>  (1)..(144)

<400>  80
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccttcgg       60

cccagagctg ctcctaaatc acgtccgccc tccacggcaa aaccagccca ccagcgggtc      120

caaagccgca cgcccgcctc ccca                                             144


<210>  81
<211>  138
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  hIDUA_W402X_RG-V21_3xRS(26-14-14-20p8)_3xA_Version #8
<222>  (1)..(138)

<400>  81
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccttcgg       60

cccagagctg ctcctaaaag ctcaggaagg caaaagacca gcccaccaga aagtccagcc      120

gcacgcccgc ctccccag                                                    138


<210>  82
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  hIDUA_W402X_RG-V21_3xRS(15-15-15-20p8)_3xA_Version #9
<222>  (1)..(129)

<400>  82
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccttcgg       60

cccagagctg ctcctaaagc gccagcagcc ccaaaatgcg gcgggcgggt gaaatggaag      120

cgcgcggtg                                                              129


<210>  83
<211>  134
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  hIDUA_W402X_RG-V21_3xRS(20-15-15-20p8)_3xA_Version #10
<222>  (1)..(134)

<400>  83
ctggtgggct ggtccctgcc tttcaccgcg cgcttccatt tcacccgccc gccgcattta       60

ggagcagctc tgggccgaag gtgtcgagga gacgagaaca acatttagca tattgttctc      120

ctcttctcga cacc                                                        134


<210>  84
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA Oligo


<220>
<221>  Fluc_W417X_Universal_fw
<222>  (1)..(21)

<400>  84
acttggacac cggtaagaca c                                                 21


<210>  85
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA Oligo


<220>
<221>  Fluc_W417X_Universal_bw
<222>  (1)..(21)

<400>  85
acgatgaaga agtgctcgtc c                                                 21


<210>  86
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA Oligo


<220>
<221>  Fluc_W417X_Nested_fw
<222>  (1)..(18)

<400>  86
tgggtgtgaa ccagcgcg                                                     18


<210>  87
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA Oligo


<220>
<221>  Fluc_W417X_Nested_bw
<222>  (1)..(19)

<400>  87
gtcccagtag gcgatgtcg                                                    19


<210>  88
<211>  8062
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid containing a 2A peptide interrupted dual-luciferase 
       (firefly, renilla) construct behind a CMV promoter. Both 
       luciferases are functional.


<220>
<221>  Renilla-Luciferase_wt
<222>  (906)..(1838)

<220>
<221>  2A-peptide
<222>  (1839)..(1904)

<220>
<221>  Firefly-Luciferase_wt
<222>  (1905)..(3557)

<400>  88
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttctagat      900

aagatatgac ttcgaaagtt tatgatccag aacaaaggaa acggatgata actggtccgc      960

agtggtgggc cagatgtaaa caaatgaatg ttcttgattc atttattaat tattatgatt     1020

cagaaaaaca tgcagaaaat gctgttattt ttttacatgg taacgcggcc tcttcttatt     1080

tatggcgaca tgttgtgcca catattgagc cagtagcgcg gtgtattata ccagacctta     1140

ttggtatggg caaatcaggc aaatctggta atggttctta taggttactt gatcattaca     1200

aatatcttac tgcatggttt gaacttctta atttaccaaa gaagatcatt tttgtcggcc     1260

atgattgggg tgcttgtttg gcatttcatt atagctatga gcatcaagat aagatcaaag     1320

caatagttca cgctgaaagt gtagtagatg tgattgaatc atgggatgaa tggcctgata     1380

ttgaagaaga tattgcgttg atcaaatctg aagaaggaga aaaaatggtt ttggagaata     1440

acttcttcgt ggaaaccatg ttgccatcaa aaatcatgag aaagttagaa ccagaagaat     1500

ttgcagcata tcttgaacca ttcaaagaga aaggtgaagt tcgtcgtcca acattatcat     1560

ggcctcgtga aatcccgtta gtaaaaggtg gtaaacctga cgttgtacaa attgttagga     1620

attataatgc ttatctacgt gcaagtgatg atttaccaaa aatgtttatt gaatcggacc     1680

caggattctt ttccaatgct attgttgaag gtgccaagaa gtttcctaat actgaatttg     1740

tcaaagtaaa aggtcttcat ttttcgcaag aagatgcacc tgatgaaatg ggaaaatata     1800

tcaaatcgtt cgttgagcga gttctcaaaa atgaacaagg aagcggagct actaacttca     1860

gcctgctgaa gcaggctgga gacgtggagg agaaccctgg acctatggaa gatgccaaaa     1920

acattaagaa gggcccagcg ccattctacc cactcgaaga cgggaccgcc ggcgagcagc     1980

tgcacaaagc catgaagcgc tacgccctgg tgcccggcac catcgccttt accgacgcac     2040

atatcgaggt ggacattacc tacgccgagt acttcgagat gagcgttcgg ctggcagaag     2100

ctatgaagcg ctatgggctg aatacaaacc atcggatcgt ggtgtgcagc gagaatagct     2160

tgcagttctt catgcccgtg ttgggtgccc tgttcatcgg tgtggctgtg gccccagcta     2220

acgacatcta caacgagcgc gagctgctga acagcatggg catcagccag cccaccgtcg     2280

tattcgtgag caagaaaggg ctgcaaaaga tcctcaacgt gcaaaagaag ctaccgatca     2340

tacaaaagat catcatcatg gatagcaaga ccgactacca gggcttccaa agcatgtaca     2400

ccttcgtgac ttcccatttg ccacccggct tcaacgagta cgacttcgtg cccgagagct     2460

tcgaccggga caaaaccatc gccctgatca tgaacagtag tggcagtacc ggattgccca     2520

agggcgtagc cctaccgcac cgcaccgctt gtgtccgatt cagtcatgcc cgcgacccca     2580

tcttcggcaa ccagatcatc cccgacaccg ctatcctcag cgtggtgcca tttcaccacg     2640

gcttcggcat gttcaccacg ctgggctact tgatctgcgg ctttcgggtc gtgctcatgt     2700

accgcttcga ggaggagcta ttcttgcgca gcttgcaaga ctataagatt caatctgccc     2760

tgctggtgcc cacactattt agcttcttcg ctaagagcac tctcatcgac aagtacgacc     2820

taagcaactt gcacgagatc gccagcggcg gggcgccgct cagcaaggag gtaggtgagg     2880

ccgtggccaa acgcttccac ctaccaggca tccgccaggg ctacggcctg acagaaacaa     2940

ccagcgccat tctgatcacc cccgaagggg acgacaagcc tggcgcagta ggcaaggtgg     3000

tgcccttctt cgaggctaag gtggtggact tggacaccgg taagacactg ggtgtgaacc     3060

agcgcggcga gctgtgcgtc cgtggcccca tgatcatgag cggctacgtt aacaaccccg     3120

aggctacaaa cgctctcatc gacaaggacg gctggctgca cagcggcgac atcgcctact     3180

gggacgagga cgagcacttc ttcatcgtgg accggctgaa gagcctgatc aaatacaagg     3240

gctaccaggt agccccagcc gaactggaga gcatcctgct gcaacacccc aacatcttcg     3300

acgccggggt cgccggcctg cccgacgacg atgccggcga gctgcccgcc gcagtcgtcg     3360

tgctggaaca cggtaaaacc atgaccgaga aggagatcgt ggactatgtg gccagccagg     3420

tcacaaccgc caagaagctg cgcggtggtg ttgtgttcgt ggacgaggtg cctaaaggac     3480

tgaccggcaa gttggacgcc cgcaagatcc gcgagattct cattaaggcc aagaagggcg     3540

gcaagatcgc cgtgtaagaa ttctgcagat atccatcaca ctggcggccg ctcgagcatg     3600

catctagagg gccctattct atagtgtcac ctaaatgcta gagctcgctg atcagcctcg     3660

actgtgcctt ctagttgcca gccatctgtt gtttgcccct cccccgtgcc ttccttgacc     3720

ctggaaggtg ccactcccac tgtcctttcc taataaaatg aggaaattgc atcgcattgt     3780

ctgagtaggt gtcattctat tctggggggt ggggtggggc aggacagcaa gggggaggat     3840

tgggaagaca atagcaggca tgctggggat gcggtgggct ctatggcttc tgaggcggaa     3900

agaaccagct ggggctctag ggggtatccc cacgcgccct gtagcggcgc attaagcgcg     3960

gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg ccagcgccct agcgcccgct     4020

cctttcgctt tcttcccttc ctttctcgcc acgttcgccg gctttccccg tcaagctcta     4080

aatcgggggc tccctttagg gttccgattt agtgctttac ggcacctcga ccccaaaaaa     4140

cttgattagg gtgatggttc acgtagtggg ccatcgccct gatagacggt ttttcgccct     4200

ttgacgttgg agtccacgtt ctttaatagt ggactcttgt tccaaactgg aacaacactc     4260

aaccctatct cggtctattc ttttgattta taagggattt tgccgatttc ggcctattgg     4320

ttaaaaaatg agctgattta acaaaaattt aacgcgaatt aattctgtgg aatgtgtgtc     4380

agttagggtg tggaaagtcc ccaggctccc cagcaggcag aagtatgcaa agcatgcatc     4440

tcaattagtc agcaaccagg tgtggaaagt ccccaggctc cccagcaggc agaagtatgc     4500

aaagcatgca tctcaattag tcagcaacca tagtcccgcc cctaactccg cccatcccgc     4560

ccctaactcc gcccagttcc gcccattctc cgccccatgg ctgactaatt ttttttattt     4620

atgcagaggc cgaggccgcc tctgcctctg agctattcca gaagtagtga ggaggctttt     4680

ttggaggcct aggcttttgc aaaaagctcc cgggagcttg tatatccatt ttcggatctg     4740

atcaagagac aggatgagga tcgtttcgca tgattgaaca agatggattg cacgcaggtt     4800

ctccggccgc ttgggtggag aggctattcg gctatgactg ggcacaacag acaatcggct     4860

gctctgatgc cgccgtgttc cggctgtcag cgcaggggcg cccggttctt tttgtcaaga     4920

ccgacctgtc cggtgccctg aatgaactgc aggacgaggc agcgcggcta tcgtggctgg     4980

ccacgacggg cgttccttgc gcagctgtgc tcgacgttgt cactgaagcg ggaagggact     5040

ggctgctatt gggcgaagtg ccggggcagg atctcctgtc atctcacctt gctcctgccg     5100

agaaagtatc catcatggct gatgcaatgc ggcggctgca tacgcttgat ccggctacct     5160

gcccattcga ccaccaagcg aaacatcgca tcgagcgagc acgtactcgg atggaagccg     5220

gtcttgtcga tcaggatgat ctggacgaag agcatcaggg gctcgcgcca gccgaactgt     5280

tcgccaggct caaggcgcgc atgcccgacg gcgaggatct cgtcgtgacc catggcgatg     5340

cctgcttgcc gaatatcatg gtggaaaatg gccgcttttc tggattcatc gactgtggcc     5400

ggctgggtgt ggcggaccgc tatcaggaca tagcgttggc tacccgtgat attgctgaag     5460

agcttggcgg cgaatgggct gaccgcttcc tcgtgcttta cggtatcgcc gctcccgatt     5520

cgcagcgcat cgccttctat cgccttcttg acgagttctt ctgagcggga ctctggggtt     5580

cgaaatgacc gaccaagcga cgcccaacct gccatcacga gatttcgatt ccaccgccgc     5640

cttctatgaa aggttgggct tcggaatcgt tttccgggac gccggctgga tgatcctcca     5700

gcgcggggat ctcatgctgg agttcttcgc ccaccccaac ttgtttattg cagcttataa     5760

tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt tttcactgca     5820

ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgta taccgtcgac     5880

ctctagctag agcttggcgt aatcatggtc atagctgttt cctgtgtgaa attgttatcc     5940

gctcacaatt ccacacaaca tacgagccgg aagcataaag tgtaaagcct ggggtgccta     6000

atgagtgagc taactcacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa     6060

cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat     6120

tgggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg     6180

agcggtatca gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc     6240

aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt     6300

gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag     6360

tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc     6420

cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc     6480

ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt     6540

cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt     6600

atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc     6660

agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa     6720

gtggtggcct aactacggct acactagaag aacagtattt ggtatctgcg ctctgctgaa     6780

gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg     6840

tagcggtttt tttgtttgca agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga     6900

tcctttgatc ttttctacgg ggtctgacgc tcagtggaac gaaaactcac gttaagggat     6960

tttggtcatg agattatcaa aaaggatctt cacctagatc cttttaaatt aaaaatgaag     7020

ttttaaatca atctaaagta tatatgagta aacttggtct gacagttacc aatgcttaat     7080

cagtgaggca cctatctcag cgatctgtct atttcgttca tccatagttg cctgactccc     7140

cgtcgtgtag ataactacga tacgggaggg cttaccatct ggccccagtg ctgcaatgat     7200

accgcgagac ccacgctcac cggctccaga tttatcagca ataaaccagc cagccggaag     7260

ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc atccagtcta ttaattgttg     7320

ccgggaagct agagtaagta gttcgccagt taatagtttg cgcaacgttg ttgccattgc     7380

tacaggcatc gtggtgtcac gctcgtcgtt tggtatggct tcattcagct ccggttccca     7440

acgatcaagg cgagttacat gatcccccat gttgtgcaaa aaagcggtta gctccttcgg     7500

tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta tcactcatgg ttatggcagc     7560

actgcataat tctcttactg tcatgccatc cgtaagatgc ttttctgtga ctggtgagta     7620

ctcaaccaag tcattctgag aatagtgtat gcggcgaccg agttgctctt gcccggcgtc     7680

aatacgggat aataccgcgc cacatagcag aactttaaaa gtgctcatca ttggaaaacg     7740

ttcttcgggg cgaaaactct caaggatctt accgctgttg agatccagtt cgatgtaacc     7800

cactcgtgca cccaactgat cttcagcatc ttttactttc accagcgttt ctgggtgagc     7860

aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg gcgacacgga aatgttgaat     7920

actcatactc ttcctttttc aatattattg aagcatttat cagggttatt gtctcatgag     7980

cggatacata tttgaatgta tttagaaaaa taaacaaata ggggttccgc gcacatttcc     8040

ccgaaaagtg ccacctgacg tc                                              8062


<210>  89
<211>  8062
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid containing a 2A peptide interrupted dual-luciferase 
       (firefly, renilla) construct behind a CMV promoter. The renilla 
       luciferases is functional. The firefly luciferase contains a 
       W417X amber mutation.


<220>
<221>  Renilla-Luciferase_wt
<222>  (906)..(1838)

<220>
<221>  2A-peptide
<222>  (1839)..(1904)

<220>
<221>  Firefly-Luciferase_W417X_amber
<222>  (1905)..(3557)

<220>
<221>  G-to-A_amber_mutation
<222>  (3154)..(3154)

<400>  89
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttctagat      900

aagatatgac ttcgaaagtt tatgatccag aacaaaggaa acggatgata actggtccgc      960

agtggtgggc cagatgtaaa caaatgaatg ttcttgattc atttattaat tattatgatt     1020

cagaaaaaca tgcagaaaat gctgttattt ttttacatgg taacgcggcc tcttcttatt     1080

tatggcgaca tgttgtgcca catattgagc cagtagcgcg gtgtattata ccagacctta     1140

ttggtatggg caaatcaggc aaatctggta atggttctta taggttactt gatcattaca     1200

aatatcttac tgcatggttt gaacttctta atttaccaaa gaagatcatt tttgtcggcc     1260

atgattgggg tgcttgtttg gcatttcatt atagctatga gcatcaagat aagatcaaag     1320

caatagttca cgctgaaagt gtagtagatg tgattgaatc atgggatgaa tggcctgata     1380

ttgaagaaga tattgcgttg atcaaatctg aagaaggaga aaaaatggtt ttggagaata     1440

acttcttcgt ggaaaccatg ttgccatcaa aaatcatgag aaagttagaa ccagaagaat     1500

ttgcagcata tcttgaacca ttcaaagaga aaggtgaagt tcgtcgtcca acattatcat     1560

ggcctcgtga aatcccgtta gtaaaaggtg gtaaacctga cgttgtacaa attgttagga     1620

attataatgc ttatctacgt gcaagtgatg atttaccaaa aatgtttatt gaatcggacc     1680

caggattctt ttccaatgct attgttgaag gtgccaagaa gtttcctaat actgaatttg     1740

tcaaagtaaa aggtcttcat ttttcgcaag aagatgcacc tgatgaaatg ggaaaatata     1800

tcaaatcgtt cgttgagcga gttctcaaaa atgaacaagg aagcggagct actaacttca     1860

gcctgctgaa gcaggctgga gacgtggagg agaaccctgg acctatggaa gatgccaaaa     1920

acattaagaa gggcccagcg ccattctacc cactcgaaga cgggaccgcc ggcgagcagc     1980

tgcacaaagc catgaagcgc tacgccctgg tgcccggcac catcgccttt accgacgcac     2040

atatcgaggt ggacattacc tacgccgagt acttcgagat gagcgttcgg ctggcagaag     2100

ctatgaagcg ctatgggctg aatacaaacc atcggatcgt ggtgtgcagc gagaatagct     2160

tgcagttctt catgcccgtg ttgggtgccc tgttcatcgg tgtggctgtg gccccagcta     2220

acgacatcta caacgagcgc gagctgctga acagcatggg catcagccag cccaccgtcg     2280

tattcgtgag caagaaaggg ctgcaaaaga tcctcaacgt gcaaaagaag ctaccgatca     2340

tacaaaagat catcatcatg gatagcaaga ccgactacca gggcttccaa agcatgtaca     2400

ccttcgtgac ttcccatttg ccacccggct tcaacgagta cgacttcgtg cccgagagct     2460

tcgaccggga caaaaccatc gccctgatca tgaacagtag tggcagtacc ggattgccca     2520

agggcgtagc cctaccgcac cgcaccgctt gtgtccgatt cagtcatgcc cgcgacccca     2580

tcttcggcaa ccagatcatc cccgacaccg ctatcctcag cgtggtgcca tttcaccacg     2640

gcttcggcat gttcaccacg ctgggctact tgatctgcgg ctttcgggtc gtgctcatgt     2700

accgcttcga ggaggagcta ttcttgcgca gcttgcaaga ctataagatt caatctgccc     2760

tgctggtgcc cacactattt agcttcttcg ctaagagcac tctcatcgac aagtacgacc     2820

taagcaactt gcacgagatc gccagcggcg gggcgccgct cagcaaggag gtaggtgagg     2880

ccgtggccaa acgcttccac ctaccaggca tccgccaggg ctacggcctg acagaaacaa     2940

ccagcgccat tctgatcacc cccgaagggg acgacaagcc tggcgcagta ggcaaggtgg     3000

tgcccttctt cgaggctaag gtggtggact tggacaccgg taagacactg ggtgtgaacc     3060

agcgcggcga gctgtgcgtc cgtggcccca tgatcatgag cggctacgtt aacaaccccg     3120

aggctacaaa cgctctcatc gacaaggacg gctagctgca cagcggcgac atcgcctact     3180

gggacgagga cgagcacttc ttcatcgtgg accggctgaa gagcctgatc aaatacaagg     3240

gctaccaggt agccccagcc gaactggaga gcatcctgct gcaacacccc aacatcttcg     3300

acgccggggt cgccggcctg cccgacgacg atgccggcga gctgcccgcc gcagtcgtcg     3360

tgctggaaca cggtaaaacc atgaccgaga aggagatcgt ggactatgtg gccagccagg     3420

tcacaaccgc caagaagctg cgcggtggtg ttgtgttcgt ggacgaggtg cctaaaggac     3480

tgaccggcaa gttggacgcc cgcaagatcc gcgagattct cattaaggcc aagaagggcg     3540

gcaagatcgc cgtgtaagaa ttctgcagat atccatcaca ctggcggccg ctcgagcatg     3600

catctagagg gccctattct atagtgtcac ctaaatgcta gagctcgctg atcagcctcg     3660

actgtgcctt ctagttgcca gccatctgtt gtttgcccct cccccgtgcc ttccttgacc     3720

ctggaaggtg ccactcccac tgtcctttcc taataaaatg aggaaattgc atcgcattgt     3780

ctgagtaggt gtcattctat tctggggggt ggggtggggc aggacagcaa gggggaggat     3840

tgggaagaca atagcaggca tgctggggat gcggtgggct ctatggcttc tgaggcggaa     3900

agaaccagct ggggctctag ggggtatccc cacgcgccct gtagcggcgc attaagcgcg     3960

gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg ccagcgccct agcgcccgct     4020

cctttcgctt tcttcccttc ctttctcgcc acgttcgccg gctttccccg tcaagctcta     4080

aatcgggggc tccctttagg gttccgattt agtgctttac ggcacctcga ccccaaaaaa     4140

cttgattagg gtgatggttc acgtagtggg ccatcgccct gatagacggt ttttcgccct     4200

ttgacgttgg agtccacgtt ctttaatagt ggactcttgt tccaaactgg aacaacactc     4260

aaccctatct cggtctattc ttttgattta taagggattt tgccgatttc ggcctattgg     4320

ttaaaaaatg agctgattta acaaaaattt aacgcgaatt aattctgtgg aatgtgtgtc     4380

agttagggtg tggaaagtcc ccaggctccc cagcaggcag aagtatgcaa agcatgcatc     4440

tcaattagtc agcaaccagg tgtggaaagt ccccaggctc cccagcaggc agaagtatgc     4500

aaagcatgca tctcaattag tcagcaacca tagtcccgcc cctaactccg cccatcccgc     4560

ccctaactcc gcccagttcc gcccattctc cgccccatgg ctgactaatt ttttttattt     4620

atgcagaggc cgaggccgcc tctgcctctg agctattcca gaagtagtga ggaggctttt     4680

ttggaggcct aggcttttgc aaaaagctcc cgggagcttg tatatccatt ttcggatctg     4740

atcaagagac aggatgagga tcgtttcgca tgattgaaca agatggattg cacgcaggtt     4800

ctccggccgc ttgggtggag aggctattcg gctatgactg ggcacaacag acaatcggct     4860

gctctgatgc cgccgtgttc cggctgtcag cgcaggggcg cccggttctt tttgtcaaga     4920

ccgacctgtc cggtgccctg aatgaactgc aggacgaggc agcgcggcta tcgtggctgg     4980

ccacgacggg cgttccttgc gcagctgtgc tcgacgttgt cactgaagcg ggaagggact     5040

ggctgctatt gggcgaagtg ccggggcagg atctcctgtc atctcacctt gctcctgccg     5100

agaaagtatc catcatggct gatgcaatgc ggcggctgca tacgcttgat ccggctacct     5160

gcccattcga ccaccaagcg aaacatcgca tcgagcgagc acgtactcgg atggaagccg     5220

gtcttgtcga tcaggatgat ctggacgaag agcatcaggg gctcgcgcca gccgaactgt     5280

tcgccaggct caaggcgcgc atgcccgacg gcgaggatct cgtcgtgacc catggcgatg     5340

cctgcttgcc gaatatcatg gtggaaaatg gccgcttttc tggattcatc gactgtggcc     5400

ggctgggtgt ggcggaccgc tatcaggaca tagcgttggc tacccgtgat attgctgaag     5460

agcttggcgg cgaatgggct gaccgcttcc tcgtgcttta cggtatcgcc gctcccgatt     5520

cgcagcgcat cgccttctat cgccttcttg acgagttctt ctgagcggga ctctggggtt     5580

cgaaatgacc gaccaagcga cgcccaacct gccatcacga gatttcgatt ccaccgccgc     5640

cttctatgaa aggttgggct tcggaatcgt tttccgggac gccggctgga tgatcctcca     5700

gcgcggggat ctcatgctgg agttcttcgc ccaccccaac ttgtttattg cagcttataa     5760

tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt tttcactgca     5820

ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgta taccgtcgac     5880

ctctagctag agcttggcgt aatcatggtc atagctgttt cctgtgtgaa attgttatcc     5940

gctcacaatt ccacacaaca tacgagccgg aagcataaag tgtaaagcct ggggtgccta     6000

atgagtgagc taactcacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa     6060

cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat     6120

tgggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg     6180

agcggtatca gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc     6240

aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt     6300

gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag     6360

tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc     6420

cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc     6480

ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt     6540

cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt     6600

atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc     6660

agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa     6720

gtggtggcct aactacggct acactagaag aacagtattt ggtatctgcg ctctgctgaa     6780

gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg     6840

tagcggtttt tttgtttgca agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga     6900

tcctttgatc ttttctacgg ggtctgacgc tcagtggaac gaaaactcac gttaagggat     6960

tttggtcatg agattatcaa aaaggatctt cacctagatc cttttaaatt aaaaatgaag     7020

ttttaaatca atctaaagta tatatgagta aacttggtct gacagttacc aatgcttaat     7080

cagtgaggca cctatctcag cgatctgtct atttcgttca tccatagttg cctgactccc     7140

cgtcgtgtag ataactacga tacgggaggg cttaccatct ggccccagtg ctgcaatgat     7200

accgcgagac ccacgctcac cggctccaga tttatcagca ataaaccagc cagccggaag     7260

ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc atccagtcta ttaattgttg     7320

ccgggaagct agagtaagta gttcgccagt taatagtttg cgcaacgttg ttgccattgc     7380

tacaggcatc gtggtgtcac gctcgtcgtt tggtatggct tcattcagct ccggttccca     7440

acgatcaagg cgagttacat gatcccccat gttgtgcaaa aaagcggtta gctccttcgg     7500

tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta tcactcatgg ttatggcagc     7560

actgcataat tctcttactg tcatgccatc cgtaagatgc ttttctgtga ctggtgagta     7620

ctcaaccaag tcattctgag aatagtgtat gcggcgaccg agttgctctt gcccggcgtc     7680

aatacgggat aataccgcgc cacatagcag aactttaaaa gtgctcatca ttggaaaacg     7740

ttcttcgggg cgaaaactct caaggatctt accgctgttg agatccagtt cgatgtaacc     7800

cactcgtgca cccaactgat cttcagcatc ttttactttc accagcgttt ctgggtgagc     7860

aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg gcgacacgga aatgttgaat     7920

actcatactc ttcctttttc aatattattg aagcatttat cagggttatt gtctcatgag     7980

cggatacata tttgaatgta tttagaaaaa taaacaaata ggggttccgc gcacatttcc     8040

ccgaaaagtg ccacctgacg tc                                              8062


<210>  90
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  Luciferase_W417X_RG-V21_3xRS(15-15-20p8-15)_3xA
<222>  (1)..(129)
<223>  Used in figure #18

<400>  90
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acacctcgtc       60

ctcgtcccag aaagtgcagc cagccgtcct tgtaaagtcc aagtccacca caaaacgcac       120

agctcgccg                                                		129


<210>  91
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.


<220>
<221>  Luciferase_W417X_RG-V21_3xRS(15-20p8-15-15)_3xA
<222>  (1)..(129)
<223>  Used in figure #18

<400>  91
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acacctcagc       60

cggtccacga aaatcgtcct cgtcccagaa agtgcagcca gccgtccttg taaagtccaa       120

gtccaccac                                                		129


<210>  92
<211>  149
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R/G-V21 motif, targeting sequence, recruitment sequences & 
       linker.

<220>
<221>  misc-feature
<222>  (1)..(3) 
<223>  chemical modification at the 2 carbon atom with 2-O-methyl
       
<220>
<221>  misc-feature
<222>  (147)..(149) 
<223>  chemical modification at the 2 carbon atom with 2-O-methyl

<220>
<221>  misc-feature
<222>  (1)..(3) 
<223>  phosphorothioate linkage
       
<220>
<221>  misc-feature
<222>  (124)..(149) 
<223>  phosphorothioate linkage

<220>
<221>  hIDUA_W402X_RG-V21_3xRS(20-20p8-25-20)_3xA_ASO
<222>  (1)..(149)
<223>  Used in figure #19


<400>  92
ggggucgaga agaggagaac aauaugcuaa auguuguucu cgucuccucg acaccgccag        60

gacgcccacc gugugaaacu guccaggacg gucccggccu gcgaaauucg gcccagagcu        120

gcuccuaaag uggggucguu gcccagccg                                          149


<210>  93
<211>  55
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RG motif version 21


<220>
<221>  RG motif version 21
<222>  (1)..(55)
<223>  Sequence-modified version of an excerpt from the human GRIA2 gene.

<400>  93
ggugucgaga agaggagaac aauaugcuaa auguuguucu cgucuccucg acacc            55


<210>  94
<211>  45
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RG motif version 1


<220>
<221>  RG motif version 1
<222>  (1)..(45)
<223>  Excerpt from the human GRIA2 gene

<400>  94
guggaauagu auaacaauau gcuaaauguu guuauaguau cccac                       45