                         SEQUENCE LISTING

<110>  Ϻ＼ι˾
       ŵҽҩƼɶ޹˾
 
<120>  ҩżＰӦ

<130>  IEC210347PCT

<160>  200   

<170>  PatentIn version 3.3

<210>  1
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv1

<400>  1

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asn 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Asn Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ser Tyr Tyr Gly Asn Ser Phe Ile Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  2
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv1 CDR1

<400>  2

Gly Tyr Ser Ile Thr Ser Asn Tyr Ala Trp Asn 
1               5                   10      


<210>  3
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv1 CDR2

<400>  3

Tyr Ile Asn Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  4
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv1 CDR3

<400>  4

Ser Tyr Tyr Gly Asn Ser Phe Ile Tyr 
1               5                   


<210>  5
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv1 FR1

<400>  5

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser 
            20                  25  


<210>  6
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv1 FR2

<400>  6

Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  7
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv1 FR3

<400>  7

Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Thr 
            20                  25                  30          


<210>  8
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv1 FR4

<400>  8

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  9
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv2

<400>  9

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Asn 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Asn Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ser Tyr Tyr Gly Asn Ser Phe Ile Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  10
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv2 CDR1

<400>  10

Gly Gly Ser Ile Ser Ser Asn Tyr Ala Trp Asn 
1               5                   10      


<210>  11
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv2 CDR2

<400>  11

Tyr Ile Asn Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  12
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv2 CDR3

<400>  12

Ser Tyr Tyr Gly Asn Ser Phe Ile Tyr 
1               5                   


<210>  13
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv2 FR1

<400>  13

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser 
            20                  25  


<210>  14
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv2 FR2

<400>  14

Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  15
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv2 FR3

<400>  15

Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Thr 
            20                  25                  30          


<210>  16
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv2 FR4

<400>  16

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  17
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv3

<400>  17

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Asn 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Asn Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ser Tyr Tyr Gly Asn Ser Phe Ile Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  18
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv3 CDR1

<400>  18

Gly Gly Ser Ile Ser Ser Asn Tyr Ala Trp Asn 
1               5                   10      


<210>  19
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv3 CDR2

<400>  19

Tyr Ile Asn Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  20
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv3 CDR3

<400>  20

Ser Tyr Tyr Gly Asn Ser Phe Ile Tyr 
1               5                   


<210>  21
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv3 FR1

<400>  21

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser 
            20                  25  


<210>  22
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv3 FR2

<400>  22

Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  23
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv3 FR3

<400>  23

Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Thr 
            20                  25                  30          


<210>  24
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv3 FR4

<400>  24

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  25
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv4

<400>  25

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Asn 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Asn Tyr Ser Gly Tyr Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ser Tyr Tyr Gly Asn Ser Phe Ile Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  26
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv4 CDR1

<400>  26

Gly Gly Ser Ile Ser Ser Asn Tyr Ala Trp Asn 
1               5                   10      


<210>  27
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv4 CDR2

<400>  27

Tyr Ile Asn Tyr Ser Gly Tyr Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  28
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv4 CDR3

<400>  28

Ser Tyr Tyr Gly Asn Ser Phe Ile Tyr 
1               5                   


<210>  29
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv4 FR1

<400>  29

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser 
            20                  25  


<210>  30
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv4 FR2

<400>  30

Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  31
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv4 FR3

<400>  31

Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Thr 
            20                  25                  30          


<210>  32
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv4 FR4

<400>  32

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  33
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv5

<400>  33

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Asn 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Asn Tyr Ser Gly Asn Thr Ala Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ser Tyr Tyr Gly Asn Ser Phe Ile Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  34
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv5 CDR1

<400>  34

Gly Gly Ser Ile Ser Ser Asn Tyr Ala Trp Asn 
1               5                   10      


<210>  35
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv5 CDR2

<400>  35

Tyr Ile Asn Tyr Ser Gly Asn Thr Ala Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  36
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv5 CDR3

<400>  36

Ser Tyr Tyr Gly Asn Ser Phe Ile Tyr 
1               5                   


<210>  37
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv5 FR1

<400>  37

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser 
            20                  25  


<210>  38
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv5 FR2

<400>  38

Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  39
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv5 FR3

<400>  39

Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Thr 
            20                  25                  30          


<210>  40
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv5 FR4

<400>  40

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  41
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv6

<400>  41

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Asn 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ser Tyr Tyr Gly Asn Ser Phe Ile Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  42
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv6 CDR1

<400>  42

Gly Gly Ser Ile Ser Ser Asn Tyr Ala Trp Asn 
1               5                   10      


<210>  43
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv6 CDR2

<400>  43

Tyr Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  44
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv6 CDR3

<400>  44

Ser Tyr Tyr Gly Asn Ser Phe Ile Tyr 
1               5                   


<210>  45
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv6 FR1

<400>  45

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser 
            20                  25  


<210>  46
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv6 FR2

<400>  46

Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  47
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv6 FR3

<400>  47

Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Thr 
            20                  25                  30          


<210>  48
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VHv6 FR4

<400>  48

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  49
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VLv1

<400>  49

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Ala Tyr Ser Phe Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  50
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VLv1 CDR1

<400>  50

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  51
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VLv1 CDR2

<400>  51

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  52
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VLv1 CDR3

<400>  52

Gln Asn Ala Tyr Ser Phe Pro Trp Thr 
1               5                   


<210>  53
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VLv1 FR1

<400>  53

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys 
            20              


<210>  54
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VLv1 FR2

<400>  54

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  55
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VLv1 FR3

<400>  55

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  56
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VLv1 FR4

<400>  56

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  57
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VLv2

<400>  57

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Ala Tyr Ser Phe Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  58
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VLv2 CDR1

<400>  58

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  59
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VLv2 CDR2

<400>  59

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  60
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VLv2 CDR3

<400>  60

Gln Gln Ala Tyr Ser Phe Pro Trp Thr 
1               5                   


<210>  61
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VLv2 FR1

<400>  61

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys 
            20              


<210>  62
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VLv2 FR2

<400>  62

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  63
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VLv2 FR3

<400>  63

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  64
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  18D10VLv2 FR4

<400>  64

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  65
<211>  448
<212>  PRT
<213>  Artificial

<220>
<223>  

<400>  65

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Asn 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ser Tyr Tyr Gly Asn Ser Phe Ile Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  66
<211>  220
<212>  PRT
<213>  Artificial

<220>
<223>  

<400>  66

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Ala Tyr Ser Phe Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  67
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv1

<400>  67

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Pro Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Gly Ser Gly Asp Thr Val Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Ser Met Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Val Arg Gly Asn Ser Phe Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  68
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv1 CDR1

<400>  68

Gly Tyr Ala Phe Thr Asn Tyr Leu Ile Asp 
1               5                   10  


<210>  69
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv1 CDR2

<400>  69

Gly Ile Asn Pro Gly Ser Gly Asp Thr Val Tyr Asn Glu Lys Phe Gln 
1               5                   10                  15      


<210>  70
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv1 CDR3

<400>  70

Arg Val Arg Gly Asn Ser Phe Asp Ser 
1               5                   


<210>  71
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv1 FR1

<400>  71

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Pro Ser 
            20                  25  


<210>  72
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv1 FR2

<400>  72

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  73
<211>  33
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv1 FR3

<400>  73

Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Ser Met Thr Ala Tyr Met 
1               5                   10                  15      


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys Ala 
            20                  25                  30          


Arg 
    


<210>  74
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv1 FR4

<400>  74

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  75
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv2

<400>  75

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Pro Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Gly Ser Gly Asp Thr Val Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Val Arg Gly Asn Ser Phe Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  76
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv2 CDR1

<400>  76

Gly Tyr Thr Phe Thr Asn Tyr Leu Ile Asp 
1               5                   10  


<210>  77
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv2 CDR2

<400>  77

Gly Ile Asn Pro Gly Ser Gly Asp Thr Val Tyr Asn Glu Lys Phe Gln 
1               5                   10                  15      


<210>  78
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv2 CDR3

<400>  78

Arg Val Arg Gly Asn Ser Phe Asp Ser 
1               5                   


<210>  79
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv2 FR1

<400>  79

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Pro Ser 
            20                  25  


<210>  80
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv2 FR2

<400>  80

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  81
<211>  33
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv2 FR3

<400>  81

Gly Arg Val Thr Leu Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met 
1               5                   10                  15      


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys Ala 
            20                  25                  30          


Arg 
    


<210>  82
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv2 FR4

<400>  82

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  83
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv3

<400>  83

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Pro Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Gly Ser Gly Asp Thr Val Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Ser Met Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Val Arg Gly Asn Ser Phe Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  84
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv3 CDR1

<400>  84

Gly Tyr Thr Phe Thr Asn Tyr Leu Ile Asp 
1               5                   10  


<210>  85
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv3 CDR2

<400>  85

Gly Ile Asn Pro Gly Ser Gly Asp Thr Val Tyr Asn Glu Lys Phe Gln 
1               5                   10                  15      


<210>  86
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv3 CDR3

<400>  86

Arg Val Arg Gly Asn Ser Phe Asp Ser 
1               5                   


<210>  87
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv3 FR1

<400>  87

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Pro Ser 
            20                  25  


<210>  88
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv3 FR2

<400>  88

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  89
<211>  33
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv3 FR3

<400>  89

Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Ser Met Thr Ala Tyr Met 
1               5                   10                  15      


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
            20                  25                  30          


Arg 
    


<210>  90
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv3 FR4

<400>  90

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  91
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv4

<400>  91

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Gly Ser Gly Asp Thr Val Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Ser Met Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Val Arg Gly Asn Ser Phe Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  92
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv4 CDR1

<400>  92

Gly Tyr Thr Phe Thr Asn Tyr Leu Ile Asp 
1               5                   10  


<210>  93
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv4 CDR2

<400>  93

Gly Ile Asn Pro Gly Ser Gly Asp Thr Val Tyr Asn Glu Lys Phe Gln 
1               5                   10                  15      


<210>  94
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv4 CDR3

<400>  94

Arg Val Arg Gly Asn Ser Phe Asp Ser 
1               5                   


<210>  95
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv4 FR1

<400>  95

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  96
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv4 FR2

<400>  96

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  97
<211>  33
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv4 FR3

<400>  97

Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Ser Met Thr Ala Tyr Met 
1               5                   10                  15      


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys Ala 
            20                  25                  30          


Arg 
    


<210>  98
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv4 FR4

<400>  98

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  99
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv5

<400>  99

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Pro Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Gly Ser Gly Asp Thr Val Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Val Arg Gly Asn Ser Phe Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  100
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv5 CDR1

<400>  100

Gly Tyr Thr Phe Thr Asn Tyr Leu Ile Asp 
1               5                   10  


<210>  101
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv5 CDR2

<400>  101

Gly Ile Asn Pro Gly Ser Gly Asp Thr Val Tyr Asn Glu Lys Phe Gln 
1               5                   10                  15      


<210>  102
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv5 CDR3

<400>  102

Arg Val Arg Gly Asn Ser Phe Asp Ser 
1               5                   


<210>  103
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv5 FR1

<400>  103

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Pro Ser 
            20                  25  


<210>  104
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv5 FR2

<400>  104

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  105
<211>  33
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv5 FR3

<400>  105

Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met 
1               5                   10                  15      


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys Ala 
            20                  25                  30          


Arg 
    


<210>  106
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv5 FR4

<400>  106

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  107
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv6

<400>  107

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Pro Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Gly Ser Gly Asp Thr Val Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Val Arg Gly Asn Ser Phe Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  108
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv6 CDR1

<400>  108

Gly Tyr Ala Phe Thr Asn Tyr Leu Ile Asp 
1               5                   10  


<210>  109
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv6 CDR2

<400>  109

Gly Ile Asn Pro Gly Ser Gly Asp Thr Val Tyr Asn Glu Lys Phe Gln 
1               5                   10                  15      


<210>  110
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv6 CDR3

<400>  110

Arg Val Arg Gly Asn Ser Phe Asp Ser 
1               5                   


<210>  111
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv6 FR1

<400>  111

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Pro Ser 
            20                  25  


<210>  112
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv6 FR2

<400>  112

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  113
<211>  33
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv6 FR3

<400>  113

Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met 
1               5                   10                  15      


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys Ala 
            20                  25                  30          


Arg 
    


<210>  114
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv6 FR4

<400>  114

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  115
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv7

<400>  115

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Pro Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Gly Ser Gly Asp Thr Val Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Val Arg Gly Asn Ser Phe Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  116
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv7 CDR1

<400>  116

Gly Tyr Thr Phe Thr Asn Tyr Leu Ile Asp 
1               5                   10  


<210>  117
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv7 CDR2

<400>  117

Gly Ile Asn Pro Gly Ser Gly Asp Thr Val Tyr Asn Glu Lys Phe Gln 
1               5                   10                  15      


<210>  118
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv7 CDR3

<400>  118

Arg Val Arg Gly Asn Ser Phe Asp Ser 
1               5                   


<210>  119
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv7 FR1

<400>  119

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Pro Ser 
            20                  25  


<210>  120
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv7 FR2

<400>  120

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  121
<211>  33
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv7 FR3

<400>  121

Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Val Tyr Met 
1               5                   10                  15      


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys Ala 
            20                  25                  30          


Arg 
    


<210>  122
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VHv7 FR4

<400>  122

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  123
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VLv1

<400>  123

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Lys Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asn Tyr Phe Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  124
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VLv1 CDR1

<400>  124

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  125
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VLv1 CDR2

<400>  125

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  126
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VLv1 CDR3

<400>  126

Gln Asn Asn Tyr Phe Tyr Pro Leu Thr 
1               5                   


<210>  127
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VLv1 FR1

<400>  127

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys 
            20              


<210>  128
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VLv1 FR2

<400>  128

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  129
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VLv1 FR3

<400>  129

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Lys Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  130
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VLv1 FR4

<400>  130

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  131
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VLv2

<400>  131

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Asn Tyr Phe Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  132
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VLv2 CDR1

<400>  132

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  133
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VLv2 CDR2

<400>  133

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  134
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VLv2 CDR3

<400>  134

Gln Gln Asn Tyr Phe Tyr Pro Leu Thr 
1               5                   


<210>  135
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VLv2 FR1

<400>  135

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys 
            20              


<210>  136
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VLv2 FR2

<400>  136

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  137
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VLv2 FR3

<400>  137

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  138
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  18A9VLv2 FR4

<400>  138

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  139
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  ¡18D10 

<400>  139

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asn 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Asn Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Ala Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ser Tyr Tyr Gly Asn Ser Phe Ile Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  140
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  ¡18D10  CDR1

<400>  140

Gly Tyr Ser Ile Thr Ser Asn Tyr Ala Trp Asn 
1               5                   10      


<210>  141
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  ¡18D10  CDR2

<400>  141

Tyr Ile Asn Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  142
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  ¡18D10  CDR3

<400>  142

Ser Tyr Tyr Gly Asn Ser Phe Ile Tyr 
1               5                   


<210>  143
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  ¡18D10  FR1

<400>  143

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr 
            20                  25  


<210>  144
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  ¡18D10  FR2

<400>  144

Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp Met Gly 
1               5                   10                  


<210>  145
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  ¡18D10  FR3

<400>  145

Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe Leu Gln 
1               5                   10                  15      


Leu Asn Ser Val Thr Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Thr 
            20                  25                  30          


<210>  146
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  ¡18D10  FR4

<400>  146

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10      


<210>  147
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  ¡18D10 

<400>  147

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Ala Tyr Ser Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  148
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  ¡18D10  CDR1

<400>  148

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  149
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  ¡18D10  CDR2

<400>  149

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  150
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  ¡18D10  CDR3

<400>  150

Gln Asn Ala Tyr Ser Phe Pro Trp Thr 
1               5                   


<210>  151
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  ¡18D10  FR1

<400>  151

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys 
            20              


<210>  152
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  ¡18D10  FR2

<400>  152

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  153
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  ¡18D10  FR3

<400>  153

Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  154
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  ¡18D10  FR4

<400>  154

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  155
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  ¡18A9 

<400>  155

Gln Val Gln Leu Gln Gln Ser Gly Arg Glu Val Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Pro Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Asp Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Gly Ser Gly Asp Thr Val Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ala Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Met Thr Ala Asn 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Val Arg Gly Asn Ser Phe Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  156
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  ¡18A9  CDR1

<400>  156

Gly Tyr Ala Phe Thr Asn Tyr Leu Ile Asp 
1               5                   10  


<210>  157
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  ¡18A9  CDR2

<400>  157

Gly Ile Asn Pro Gly Ser Gly Asp Thr Val Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


<210>  158
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  ¡18A9  CDR3

<400>  158

Arg Val Arg Gly Asn Ser Phe Asp Ser 
1               5                   


<210>  159
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  ¡18A9  FR1

<400>  159

Gln Val Gln Leu Gln Gln Ser Gly Arg Glu Val Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Pro Ser 
            20                  25  


<210>  160
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  ¡18A9  FR2

<400>  160

Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  161
<211>  33
<212>  PRT
<213>  Artificial

<220>
<223>  ¡18A9  FR3

<400>  161

Ala Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Met Thr Ala Asn Met 
1               5                   10                  15      


Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Phe Cys Ala 
            20                  25                  30          


Arg 
    


<210>  162
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  ¡18A9  FR4

<400>  162

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10      


<210>  163
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  ¡18A9 

<400>  163

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Lys Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Leu Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asn Tyr Phe Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  164
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  ¡18A9  CDR1

<400>  164

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  165
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  ¡18A9  CDR2

<400>  165

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  166
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  ¡18A9  CDR3

<400>  166

Gln Asn Asn Tyr Phe Tyr Pro Leu Thr 
1               5                   


<210>  167
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  ¡18A9  FR1

<400>  167

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys 
            20              


<210>  168
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  ¡18A9  FR2

<400>  168

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  169
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  ¡18A9  FR3

<400>  169

Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Lys Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Leu Tyr Tyr Cys 
            20                  25                  30          


<210>  170
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  ¡18A9  FR4

<400>  170

Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
1               5                   10  


<210>  171
<211>  37
<212>  DNA
<213>  Artificial

<220>
<223>  

<400>  171
ttggcaaaga attgctagat gtccaccacc acatgcc                              37


<210>  172
<211>  38
<212>  DNA
<213>  Artificial

<220>
<223>  

<400>  172
tgttcgggcc ctcctcgatt acacatagtc gtgcttgg                             38


<210>  173
<211>  37
<212>  DNA
<213>  Artificial

<220>
<223>  

<400>  173
ttggcaaaga attgctagat ggccgtgact gcctgtc                              37


<210>  174
<211>  38
<212>  DNA
<213>  Artificial

<220>
<223>  

<400>  174
tgttcgggcc ctcctcgatt acacatagtc gtgcttgg                             38


<210>  175
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  

<400>  175
tgtgcgccac catggccgtg                                                 20


<210>  176
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  

<400>  176
tggaaggata agattgtacc                                                 20


<210>  177
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  

<400>  177
tgggtgccat tggcctcctg                                                 20


<210>  178
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  ¡18D10 

<400>  178
gatgtgcagc ttcaggagtc gggacctggc ctggtgaaac cttctcagtc tctgtccctc     60

acctgcactg tcactggcta ctcaatcacc agtaattatg cctggaactg gatccgacag    120

tttccaggaa acaaactaga gtggatgggc tacataaact acagtgggaa cactaactat    180

aacccatctc tcaaaagtcg aatctctatc actcgagaca catccaagaa ccagttcttc    240

ctgcagttga attctgtgac tgctgaggac acagccacat attattgtgc aacctcctat    300

tatggtaatt cctttattta ctggggccaa gggactctgg tcactgtctc tgca          354


<210>  179
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  ¡18D10 

<400>  179
gacattgtga tgacacagtc tccatcctcc ctgactgtga cagcaggaga gaaggtcact     60

atgagctgca agtccagtca gagtctgtta aacagtggaa atcaaaagaa ctacttgacc    120

tggtaccagc agaaaccagg gcagcctcct aaactgttga tctactgggc atccactagg    180

gagtctgggg tccctgatcg cttcacaggc agtggatctg gaacagattt cactctcacc    240

atcagcagtg tgcaggctga agacctggca gtttattact gtcagaatgc ttatagtttt    300

ccgtggacgt tcggtggagg caccaagctg gaaatcaaa                           339


<210>  180
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  ¡18A9 

<400>  180
caggtgcagc tgcagcagtc tggacgtgag gtggtaaggc ctgggacttc agtgaaggtg     60

tcctgcaagc cttctggata cgccttcact aattacttga tagactgggt aaaacagagg    120

cctggacagg gccttgagtg gattggaggg attaatcctg gaagtggtga cactgtgtac    180

aatgagaagt tcaaggccaa ggcaacactg actgcagaca aatcctccat gactgccaac    240

atgcagctca gcagcctgac atctgatgac tctgcggtct atttctgcgc aagaagggtc    300

cgtggtaatt cgtttgattc ctggggccaa gggactctgg tcactgtctc tgca          354


<210>  181
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  ¡18A9 

<400>  181
gacattgtga tgtcacagtc tccatcctcc ctgactgtga cagcaggaga gaaggtcact     60

atgagctgca agtccagtca gagtctgtta aacagtggaa atcaaaagaa ctacttgacc    120

tggtaccagc agaaaccagg gcagcctcct aaattgttga tctactgggc atccactagg    180

gaatctgggg tccctgatcg cttcacaggc agtggatctg gaaaagattt cactctcacc    240

atcagcagtg tgcaggctga agacctggca ctttattact gtcagaataa ttatttttat    300

ccgctcacgt tcggtgctgg gaccaagctg gagctgaaa                           339


<210>  182
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  18D10VHv1

<400>  182
caggttcagc tgcaagagtc tggacctggc ctggtcaagc ctagcgagac actgagcctg     60

acctgtaccg tgtccggcta cagcatcacc agcaactacg cctggaactg gatcagacag    120

cctcctggca aaggcctcga gtggatcggc tacatcaact acagcggcaa caccaactac    180

aaccccagcc tgaagtccag agtgaccatc agcagagaca ccagcaagaa ccagttctcc    240

ctgaagctga gcagcgtgac agccgccgat acagccgtgt actactgtgc cacaagctac    300

tacggcaaca gcttcatcta ctggggccag ggcacactgg tcaccgtttc ttct          354


<210>  183
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  18D10VHv2

<400>  183
caggttcagc tgcaagagtc tggacctggc ctggtcaagc ctagcgagac actgagcctg     60

acctgtaccg tgtccggcgg cagcatcagc agcaactacg cctggaactg gatcagacag    120

cctcctggca aaggcctcga gtggatgggc tacatcaact acagcggcaa caccaactac    180

aaccccagcc tgaagtccag aatcaccatc agcagagaca ccagcaagaa ccagttctcc    240

ctgaagctga gcagcgtgac agccgccgat acagccgtgt actactgtgc cacaagctac    300

tacggcaaca gcttcatcta ctggggccag ggcacactgg tcaccgtttc ttct          354


<210>  184
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  18D10VHv3

<400>  184
caggttcagc tgcaagagtc tggacctggc ctggtcaagc ctagcgagac actgagcctg     60

acctgtaccg tgtccggcgg cagcatcagc agcaactacg cctggaactg gatcagacag    120

cctcctggca aaggcctcga gtggatcggc tacatcaact acagcggcaa caccaactac    180

aaccccagcc tgaagtccag agtgaccatc agcagagaca ccagcaagaa ccagttctcc    240

ctgaagctga gcagcgtgac agccgccgat acagccgtgt actactgtgc cacaagctac    300

tacggcaaca gcttcatcta ctggggccag ggcacactgg tcaccgtttc ttct          354


<210>  185
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  18D10VHv4

<400>  185
caggttcagc tgcaagagtc tggacctggc ctggtcaagc ctagcgagac actgagcctg     60

acctgtaccg tgtccggcgg cagcatcagc agcaactacg cctggaactg gatcagacag    120

cctcctggca aaggcctcga gtggatcggc tacatcaact acagcggcta caccaactac    180

aaccccagcc tgaagtccag agtgaccatc agcagagaca ccagcaagaa ccagttctcc    240

ctgaagctga gcagcgtgac agccgccgat acagccgtgt actactgtgc cacaagctac    300

tacggcaaca gcttcatcta ctggggccag ggcacactgg tcaccgtttc ttct          354


<210>  186
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  18D10VHv5

<400>  186
caggttcagc tgcaagagtc tggacctggc ctggtcaagc ctagcgagac actgagcctg     60

acctgtaccg tgtccggcgg cagcatcagc agcaactacg cctggaactg gatcagacag    120

cctcctggca aaggcctcga gtggatcggc tacatcaact acagcggcaa caccgcctac    180

aaccccagcc tgaagtccag agtgaccatc agcagagaca ccagcaagaa ccagttctcc    240

ctgaagctga gcagcgtgac agccgccgat acagccgtgt actactgtgc cacaagctac    300

tacggcaaca gcttcatcta ctggggccag ggcacactgg tcaccgtttc ttct          354


<210>  187
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  18D10VHv6

<400>  187
caggttcagc tgcaagagtc tggacctggc ctggtcaagc ctagcgagac actgagcctg     60

acctgtaccg tgtccggcgg cagcatcagc agcaactacg cctggaactg gatcagacag    120

cctcctggca aaggcctcga gtggatcggc tacatctact acagcggcaa caccaactac    180

aaccccagcc tgaagtccag agtgaccatc agcagagaca ccagcaagaa ccagttctcc    240

ctgaagctga gcagcgtgac agccgccgat acagccgtgt actactgtgc cacaagctac    300

tacggcaaca gcttcatcta ctggggccag ggcacactgg tcaccgtttc ttct          354


<210>  188
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  18D10VLv1

<400>  188
gacatcgtga tgacacagag ccctgatagc ctggccgtgt ctctgggaga gagagccacc     60

atcaactgca agagcagcca gagcctgctg aacagcggca accagaagaa ctacctgacc    120

tggtatcagc agaagcccgg ccagcctcct aagctgctga tctactgggc cagcaccaga    180

gaaagcggcg tgccagatag attcagcggc agcggctctg gaaccgactt caccctgaca    240

atcagctccc tgcaggccga ggatgtggcc gtgtactact gtcagaacgc ctacagcttc    300

ccctggacat tcggccaggg caccaaggtg gaaatcaag                           339


<210>  189
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  18D10VLv2

<400>  189
gacatcgtga tgacacagag ccctgatagc ctggccgtgt ctctgggaga gagagccacc     60

atcaactgca agagcagcca gagcctgctg aacagcggca accagaagaa ctacctggcc    120

tggtatcagc agaagcccgg ccagcctcct aagctgctga tctactgggc cagcaccaga    180

gaaagcggcg tgccagatag attcagcggc agcggctctg gaaccgactt caccctgaca    240

atcagctccc tgcaggccga ggatgtggcc gtgtactact gtcagcaggc ctacagcttc    300

ccctggacat tcggccaggg caccaaggtg gaaatcaag                           339


<210>  190
<211>  1347
<212>  DNA
<213>  Artificial

<220>
<223>  

<400>  190
caggttcagc tgcaagagtc tggacctggc ctggtcaagc ctagcgagac actgagcctg     60

acctgtaccg tgtccggcgg cagcatcagc agcaactacg cctggaactg gatcagacag    120

cctcctggca aaggcctcga gtggatcggc tacatctact acagcggcaa caccaactac    180

aaccccagcc tgaagtccag agtgaccatc agcagagaca ccagcaagaa ccagttctcc    240

ctgaagctga gcagcgtgac agccgccgat acagccgtgt actactgtgc cacaagctac    300

tacggcaaca gcttcatcta ctggggccag ggcacactgg tcaccgtttc ttctgctagc    360

accaagggcc catccgtctt ccccctggca ccctcctcca agagcacctc tgggggcaca    420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac    480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc    540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc    600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agagagttga gcccaaatct    660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca    720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc    780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg    840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg    900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac    960

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc   1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc   1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg   1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac   1200

tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag   1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag   1320

tccctctccc tgtctccggg taaatga                                       1347


<210>  191
<211>  663
<212>  DNA
<213>  Artificial

<220>
<223>  

<400>  191
gacatcgtga tgacacagag ccctgatagc ctggccgtgt ctctgggaga gagagccacc     60

atcaactgca agagcagcca gagcctgctg aacagcggca accagaagaa ctacctgacc    120

tggtatcagc agaagcccgg ccagcctcct aagctgctga tctactgggc cagcaccaga    180

gaaagcggcg tgccagatag attcagcggc agcggctctg gaaccgactt caccctgaca    240

atcagctccc tgcaggccga ggatgtggcc gtgtactact gtcagaacgc ctacagcttc    300

ccctggacat tcggccaggg caccaaggtg gaaatcaagc gaactgtggc tgcaccatct    360

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc    420

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc    480

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc    540

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc    600

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt    660

tag                                                                  663


<210>  192
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  18A9VHv1

<400>  192
caggttcagc tggttcagtc tggcgccgaa gtgaagaaac ctggcagcag cgtgaaggtg     60

tcctgcaagc cttctggcta cgccttcacc aactacctga tcgactgggt ccgacaggct    120

cctggacagg gacttgaatg gatgggcggc atcaaccctg gcagcggcga tacagtgtac    180

aacgagaagt tccagggcag agtgaccctg accgccgaca agtctagcat gaccgcctac    240

atggaactga gcagcctgag aagcgaggat accgccgtgt acttctgtgc cagaagagtg    300

cggggcaaca gcttcgattc ttggggccag ggaaccctgg tcaccgtttc ttct          354


<210>  193
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  18A9VHv2

<400>  193
caggttcagc tggttcagtc tggcgccgaa gtgaagaaac ctggcagcag cgtgaaggtg     60

tcctgcaagc cttctggcta caccttcacc aactacctga tcgactgggt ccgacaggct    120

cctggacagg gacttgaatg gatgggcggc atcaaccctg gcagcggcga tacagtgtac    180

aacgagaagt tccagggcag agtgaccctg accgccgacg agtctaccag caccgcctac    240

atggaactga gcagcctgag aagcgaggat accgccgtgt acttctgtgc cagaagagtg    300

cggggcaaca gcttcgattc ttggggccag ggaaccctgg tcaccgtttc ttct          354


<210>  194
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  18A9VHv3

<400>  194
caggttcagc tggttcagtc tggcgccgaa gtgaagaaac ctggcagcag cgtgaaggtg     60

tcctgcaagc cttctggcta caccttcacc aactacctga tcgactgggt ccgacaggct    120

cctggacagg gacttgaatg gatgggcggc atcaaccctg gcagcggcga tacagtgtac    180

aacgagaagt tccagggcag agtgaccctg accgccgaca agtctagcat gaccgcctac    240

atggaactga gcagcctgag aagcgaggat accgccgtgt actactgtgc cagaagagtg    300

cggggcaaca gcttcgattc ttggggccag ggaaccctgg tcaccgtttc ttct          354


<210>  195
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  18A9VHv4

<400>  195
caggttcagc tggttcagtc tggcgccgaa gtgaagaaac ctggcagcag cgtgaaggtg     60

tcctgcaagg cttctggcta caccttcacc aactacctga tcgactgggt ccgacaggct    120

cctggacagg gacttgaatg gatgggcggc atcaaccctg gcagcggcga tacagtgtac    180

aacgagaagt tccagggcag agtgaccctg accgccgaca agtctagcat gaccgcctac    240

atggaactga gcagcctgag aagcgaggat accgccgtgt acttctgtgc cagaagagtg    300

cggggcaaca gcttcgattc ttggggccag ggaaccctgg tcaccgtttc ttct          354


<210>  196
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  18A9VHv5

<400>  196
caggttcagc tggttcagtc tggcgccgaa gtgaagaaac ctggcagcag cgtgaaggtg     60

tcctgcaagc cttctggcta caccttcacc aactacctga tcgactgggt ccgacaggct    120

cctggacagg gacttgaatg gatgggcggc atcaaccctg gcagcggcga tacagtgtac    180

aacgagaagt tccagggcag agtgaccatc accgccgacg agtctaccag caccgcctac    240

atggaactga gcagcctgag aagcgaggat accgccgtgt acttctgtgc cagaagagtg    300

cggggcaaca gcttcgattc ttggggccag ggaaccctgg tcaccgtttc ttct          354


<210>  197
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  18A9VHv6

<400>  197
caggttcagc tggttcagtc tggcgccgaa gtgaagaaac ctggcgccag cgtgaaggtg     60

tcctgcaagc cttctggcta cgccttcacc aactacctga tcgactgggt ccgacaggct    120

cctggacagg gacttgaatg gatgggcggc atcaaccctg gcagcggcga tacagtgtac    180

aacgagaagt tccagggcag agtgaccctg accgccgaca agtctagcag caccgcctac    240

atggaactga gcagcctgag aagcgaggat accgccgtgt acttctgtgc cagaagagtg    300

cggggcaaca gcttcgattc ttggggccag ggaaccctgg tcaccgtttc ttct          354


<210>  198
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  18A9VHv7

<400>  198
caggttcagc tggttcagtc tggcgccgaa gtgaagaaac ctggcgccag cgtgaaggtg     60

tcctgcaagc cttctggcta caccttcacc aactacctga tcgactgggt ccgacaggct    120

cctggacagg gacttgaatg gatgggcggc atcaaccctg gcagcggcga tacagtgtac    180

aacgagaagt tccagggcag agtgaccctg accgccgaca cctctaccag caccgtctac    240

atggaactga gcagcctgag aagcgaggat accgccgtgt acttctgtgc cagaagagtg    300

cggggcaaca gcttcgattc ttggggccag ggaaccctgg tcaccgtttc ttct          354


<210>  199
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  18A9VLv1

<400>  199
gacatcgtga tgacacagag ccctgatagc ctggccgtgt ctctgggaga gagagccacc     60

atcaactgca agagcagcca gagcctgctg aacagcggca accagaagaa ctacctgacc    120

tggtatcagc agaagcccgg ccagcctcct aagctgctga tctactgggc cagcaccaga    180

gaaagcggcg tgccagatag attcagcggc agcggctctg gaaaggactt caccctgaca    240

atcagctccc tgcaggccga ggatgtggcc gtgtactact gccagaacaa ctacttctac    300

cctctgacct tcggcggagg caccaaggtg gaaatcaag                           339


<210>  200
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  18A9VLv2

<400>  200
gacatcgtga tgacacagag ccctgatagc ctggccgtgt ctctgggaga gagagccacc     60

atcaactgca agagcagcca gagcctgctg aacagcggca accagaagaa ctacctggcc    120

tggtatcagc agaagcccgg ccagcctcct aagctgctga tctactgggc cagcaccaga    180

gaaagcggcg tgccagatag attcagcggc agcggctctg gaaccgactt caccctgaca    240

atcagctccc tgcaggccga ggatgtggcc gtgtactact gccagcagaa ctacttctac    300

cctctgacct tcggcggagg caccaaggtg gaaatcaag                           339


