﻿                         序列表

<110>  昆山新蕴达生物科技有限公司

<120>  抗体-药物偶联物及其应用

<130>  IEC210236PCT

<160>  6

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  214
<212>  PRT
<213>  hRS7 light chain(Homo sapiens)

<400>  1
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Ala 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Leu 
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210>  2
<211>  451
<212>  PRT
<213>  hRS7 heavy chain(Homo sapiens)

<400>  2
Gln Val Gln Leu Gln Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              
Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Thr Asp Asp Phe 
    50                  55                  60                  
Lys Gly Arg Phe Ala Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Ile Ser Ser Leu Lys Ala Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Arg Gly Gly Phe Gly Ser Ser Tyr Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         
Gln Gly Ser Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             
Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         
Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             
Pro Gly Lys 
    450     

<210>  3
<211>  642
<212>  DNA
<213>  hRS7 light chain(Homo sapiens)

<400>  3
gacatccagc tgacccagtc cccatcttct ctgtccgcta gtgtgggcga cagagtgtct        60
atcacatgca aggcgtctca ggacgtgagc atcgccgtgg cttggtatca gcagaagccc       120
ggcaaggccc caaagctgct catctactcc gcttcttaca gatacaccgg cgtgcccgac       180
cggttcagcg gctctggctc tggcacagac ttcacactga caatctctag cttgcagcct       240
gaggacttcg ccgtgtacta ctgccagcag cactacatca ccccactcac attcggcgct       300
ggcaccaagg tggagatcaa gagaacagtg gccgctccta gcgtgttcat cttccctcct       360
agcgacgagc agctgaagag cggcaccgct tccgtggtgt gcctgctgaa caacttctac       420
cctcgggagg ctaaggtgca gtggaaggtg gacaacgccc ttcaatccgg caactctcag       480
gagtctgtga ccgagcagga ctctaaggac tccacatact ccctgtcctc cacactgaca       540
ctgtctaagg ccgactacga gaagcacaag gtgtacgctt gcgaggtgac ccaccagggc       600
ctcagctctc ctgtgacaaa gtctttcaac cggggcgagt gc                          642

<210>  4
<211>  1353
<212>  DNA
<213>  hRS7 heavy chain(Homo sapiens)

<400>  4
caggtgcagc tccagcagtc cggcagcgag ctgaagaagc ctggcgcttc tgtgaaggtg        60
tcttgcaagg cgagtggcta cacattcacc aactacggca tgaactgggt gaagcaggct       120
cctggccagg gcctcaagtg gatgggctgg atcaacacat acacaggcga gccaacatac       180
acagacgact tcaagggccg gttcgctttc agcctcgaca cctctgtgtc taccgcttac       240
ctacagatca gctccctgaa ggccgacgac accgctgtgt acttctgcgc tagaggcggc       300
ttcggcagct cttactggta cttcgacgtg tggggccagg gctctctcgt gacagtgtct       360
agcgccagca caaagggccc atccgtgttc ccactcgctc cttcttctaa gtctacatct       420
ggcggcaccg ccgccctcgg ctgcctcgtg aaggactact tcccagagcc tgtgacagtg       480
tcttggaact ccggcgccct cacatccggc gtgcacacat tccccgccgt gttacaatct       540
agcggcctgt actctttaag ctctgtggtg accgtgccat ctagctctct cggcacccag       600
acctacatct gcaacgtgaa ccacaagcca tctaacacca aggtggacaa gagagtggag       660
ccaaagtctt gcgacaagac ccacacatgc ccaccttgcc ccgcccccga gctgctgggc       720
ggcccatctg tgttcctgtt cccacctaag ccaaaggaca cactcatgat cagcagaacc       780
cccgaggtga catgcgtggt ggtggacgtg tctcacgagg accccgaggt gaagttcaac       840
tggtacgtgg acggcgtgga ggtgcacaac gctaagacca agccacggga ggagcagtac       900
aacagcacct accgggtggt gagcgtgctg accgtgctgc accaggactg gctgaacggc       960
aaggagtaca agtgcaaggt gtccaacaag gctctgcccg cccctatcga gaagacaatc      1020
agcaaggcta agggccagcc tagagagcct caggtgtaca cactgcctcc atctcgggag      1080
gagatgacaa agaaccaggt gagcctcaca tgcctcgtga agggcttcta ccctagcgac      1140
atcgccgtgg agtgggagtc taacggccag cctgagaaca actacaagac cacccctcca      1200
gtgctcgact ccgacggctc tttcttcctg tactctaagc tgacagtgga caagtccaga      1260
tggcagcagg gcaacgtgtt ctcttgctcc gtgatgcacg aggccctcca caaccactac      1320
acccagaagt ccctgtccct gtctcctggc aag                                   1353

<210>  5
<211>  214
<212>  PRT
<213>  曲妥珠 轻链(Homo sapiens)

<400>  5
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Ala Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Ala Tyr Glu Lys His Ala Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210>  6
<211>  221
<212>  PRT
<213>  曲妥珠 重链(Homo sapiens)

<400>  6
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220     

