                         SEQUENCE LISTING

<110>  Boehringer Ingelheim Animal Health USA Inc.
 
<120>  Fusion protein comprising Circoviridae capsid protein, and 
       chimeric virus-like particles composed thereof

<130>  01-3437

<160>  33    

<170>  PatentIn version 3.5

<210>  1
<211>  233
<212>  PRT
<213>  Porcine circovirus

<400>  1

Met Thr Tyr Pro Arg Arg Arg Tyr Arg Arg Arg Arg His Arg Pro Arg 
1               5                   10                  15      


Ser His Leu Gly Gln Ile Leu Arg Arg Arg Pro Trp Leu Val His Pro 
            20                  25                  30          


Arg His Arg Tyr Arg Trp Arg Arg Lys Asn Gly Ile Phe Asn Thr Arg 
        35                  40                  45              


Leu Ser Arg Thr Phe Gly Tyr Thr Val Lys Ala Thr Thr Val Thr Thr 
    50                  55                  60                  


Pro Ser Trp Ala Val Asp Met Met Arg Phe Asn Ile Asp Asp Phe Val 
65                  70                  75                  80  


Pro Pro Gly Gly Gly Thr Asn Lys Ile Ser Ile Pro Phe Glu Tyr Tyr 
                85                  90                  95      


Arg Ile Arg Lys Val Lys Val Glu Phe Trp Pro Cys Ser Pro Ile Thr 
            100                 105                 110         


Gln Gly Asp Arg Gly Val Gly Ser Thr Ala Val Ile Leu Asp Asp Asn 
        115                 120                 125             


Phe Val Thr Lys Ala Thr Ala Leu Thr Tyr Asp Pro Tyr Val Asn Tyr 
    130                 135                 140                 


Ser Ser Arg His Thr Ile Pro Gln Pro Phe Ser Tyr His Ser Arg Tyr 
145                 150                 155                 160 


Phe Thr Pro Lys Pro Val Leu Asp Ser Thr Ile Asp Tyr Phe Gln Pro 
                165                 170                 175     


Asn Asn Lys Arg Asn Gln Leu Trp Leu Arg Leu Gln Thr Ser Arg Asn 
            180                 185                 190         


Val Asp His Val Gly Leu Gly Thr Ala Phe Glu Asn Ser Lys Tyr Asp 
        195                 200                 205             


Gln Asp Tyr Asn Ile Arg Val Thr Met Tyr Val Gln Phe Arg Glu Phe 
    210                 215                 220                 


Asn Leu Lys Asp Pro Pro Leu Glu Pro 
225                 230             


<210>  2
<211>  234
<212>  PRT
<213>  Porcine circovirus

<400>  2

Met Thr Tyr Pro Arg Arg Arg Phe Arg Arg Arg Arg His Arg Pro Arg 
1               5                   10                  15      


Ser His Leu Gly Gln Ile Leu Arg Arg Arg Pro Trp Leu Val His Pro 
            20                  25                  30          


Arg His Arg Tyr Arg Trp Arg Arg Lys Asn Gly Ile Phe Asn Thr Arg 
        35                  40                  45              


Leu Ser Arg Thr Ile Gly Tyr Thr Val Lys Lys Thr Thr Val Arg Thr 
    50                  55                  60                  


Pro Ser Trp Asn Val Asp Met Met Arg Phe Asn Ile Asn Asp Phe Leu 
65                  70                  75                  80  


Pro Pro Gly Gly Gly Ser Asn Pro Leu Thr Val Pro Phe Glu Tyr Tyr 
                85                  90                  95      


Arg Ile Arg Lys Val Lys Val Glu Phe Trp Pro Cys Ser Pro Ile Thr 
            100                 105                 110         


Gln Gly Asp Arg Gly Val Gly Ser Thr Ala Val Ile Leu Asp Asp Asn 
        115                 120                 125             


Phe Val Thr Lys Ala Asn Ala Leu Thr Tyr Asp Pro Tyr Val Asn Tyr 
    130                 135                 140                 


Ser Ser Arg His Thr Ile Thr Gln Pro Phe Ser Tyr His Ser Arg Tyr 
145                 150                 155                 160 


Phe Thr Pro Lys Pro Val Leu Asp Arg Thr Ile Asp Tyr Phe Gln Pro 
                165                 170                 175     


Asn Asn Lys Arg Asn Gln Leu Trp Leu Arg Leu Gln Thr Thr Gly Asn 
            180                 185                 190         


Val Asp His Val Gly Leu Gly Thr Ala Phe Glu Asn Ser Ile Tyr Asp 
        195                 200                 205             


Gln Asp Tyr Asn Ile Arg Ile Thr Met Tyr Val Gln Phe Arg Glu Phe 
    210                 215                 220                 


Asn Leu Lys Asp Pro Pro Leu Asn Pro Lys 
225                 230                 


<210>  3
<211>  243
<212>  PRT
<213>  Bat associated circovirus

<400>  3

Met Val Tyr Arg Arg Arg Arg Gly Arg Gly Arg Arg Ala Arg Pro Met 
1               5                   10                  15      


Ser Ser Leu Gly Arg Leu Leu Tyr Arg Lys Pro Trp Leu Met His Pro 
            20                  25                  30          


Arg Phe Arg Ala Arg Tyr Arg Trp Arg Arg Lys Asn Gly Ile Thr Asn 
        35                  40                  45              


Leu Arg Leu Thr Arg Gln Val Glu Leu Trp Val Pro Lys Asp Ala Ala 
    50                  55                  60                  


Asn Ala Ser Phe Tyr Val Asn His Tyr Thr Phe Asp Leu Asp Asp Phe 
65                  70                  75                  80  


Ile Pro Ala Gly Thr Gln Leu Asn Ser Ser Pro Leu Pro Phe Lys Tyr 
                85                  90                  95      


Tyr Arg Ile Arg Lys Val Lys Val Glu Phe Gln Pro Arg Leu Pro Ile 
            100                 105                 110         


Thr Ser Pro Phe Arg Gly Tyr Gly Ser Thr Val Pro Ile Leu Asp Gly 
        115                 120                 125             


Ala Phe Val Thr Pro Ala Thr Gly Glu Ser Asp Pro Ile Trp Asp Pro 
    130                 135                 140                 


Tyr Ile Asn Phe Ser Gly Arg His Val Ile Arg Thr Pro Ala Trp Tyr 
145                 150                 155                 160 


His Lys Arg Tyr Phe Thr Pro Lys Pro Leu Ile Asp Gly Asn Thr Gly 
                165                 170                 175     


Phe Phe Gln Pro Asn Asn Lys Gln Asn Ala Leu Trp Phe Pro Asn Lys 
            180                 185                 190         


Gln Gly Gln Asn Ile Gln Trp Ser Gly Leu Gly Phe Ala Met Gln Lys 
        195                 200                 205             


Gly Asn Glu Ala Tyr Asn Tyr Gln Val Arg Phe Thr Leu Tyr Val Gln 
    210                 215                 220                 


Phe Arg Glu Phe Asp Leu Phe Asn Asn Lys Tyr Thr Ala His Met Asp 
225                 230                 235                 240 


Val Pro Leu 
            


<210>  4
<211>  247
<212>  PRT
<213>  Beak and feather disease virus

<400>  4

Met Trp Gly Thr Ser Asn Cys Ala Cys Ala Thr Phe Gln Ile Arg Arg 
1               5                   10                  15      


Arg Tyr Ala Arg Pro Tyr Arg Arg Arg His Ile Arg Arg Tyr Arg Arg 
            20                  25                  30          


Arg Arg Arg His Phe Arg Arg Arg Arg Phe Ser Thr Asn Arg Ile Tyr 
        35                  40                  45              


Thr Leu Arg Leu Thr Arg Gln Phe Gln Phe Lys Ile Asn Lys Gln Thr 
    50                  55                  60                  


Thr Ser Val Gly Asn Leu Ile Phe Asn Ala Asp Tyr Ile Thr Phe Ala 
65                  70                  75                  80  


Leu Asp Asp Phe Leu Gln Ala Val Pro Asn Pro His Thr Leu Asn Phe 
                85                  90                  95      


Glu Asp Tyr Arg Ile Lys Leu Ala Lys Met Glu Met Arg Pro Thr Gly 
            100                 105                 110         


Gly His Tyr Thr Val Gln Ser Asp Gly Phe Gly His Thr Ala Val Ile 
        115                 120                 125             


Gln Asp Ser Arg Ile Thr Arg Phe Lys Thr Thr Ala Asp Gln Thr Gln 
    130                 135                 140                 


Asp Pro Leu Ala Pro Phe Asp Gly Ala Lys Lys Trp Phe Val Ser Arg 
145                 150                 155                 160 


Gly Phe Lys Arg Leu Leu Arg Pro Lys Pro Gln Ile Thr Ile Glu Asp 
                165                 170                 175     


Leu Thr Thr Ala Asn Gln Ser Ala Ala Leu Trp Leu Asn Ser Ala Arg 
            180                 185                 190         


Thr Gly Trp Ile Pro Leu Gln Gly Gly Pro Asn Ser Ala Gly Thr Lys 
        195                 200                 205             


Val Arg His Tyr Gly Ile Ala Phe Ser Phe Pro Gln Pro Glu Gln Thr 
    210                 215                 220                 


Ile Thr Tyr Val Thr Lys Leu Thr Leu Tyr Val Gln Phe Arg Gln Phe 
225                 230                 235                 240 


Ala Pro Asn Asn Pro Ser Thr 
                245         


<210>  5
<211>  247
<212>  PRT
<213>  Rotavirus

<400>  5

Met Ala Ser Leu Ile Tyr Arg Gln Leu Leu Thr Asn Ser Tyr Thr Val 
1               5                   10                  15      


Asn Leu Ser Asp Glu Ile Gln Glu Ile Gly Ser Ala Lys Ser Gln Asp 
            20                  25                  30          


Val Thr Ile Asn Pro Gly Pro Phe Ala Gln Thr Gly Tyr Ala Pro Val 
        35                  40                  45              


Asn Trp Gly Ala Gly Glu Thr Asn Asp Ser Thr Thr Val Glu Pro Leu 
    50                  55                  60                  


Leu Asp Gly Pro Tyr Gln Pro Thr Thr Phe Asn Pro Pro Thr Ser Tyr 
65                  70                  75                  80  


Trp Val Leu Leu Ala Pro Thr Val Glu Gly Val Ile Ile Gln Gly Thr 
                85                  90                  95      


Asn Asn Thr Asp Arg Trp Leu Ala Thr Ile Leu Ile Glu Pro Asn Val 
            100                 105                 110         


Gln Thr Thr Asn Arg Ile Tyr Asn Leu Phe Gly Gln Gln Val Thr Leu 
        115                 120                 125             


Ser Val Glu Asn Thr Ser Gln Thr Gln Trp Lys Phe Ile Asp Val Ser 
    130                 135                 140                 


Thr Thr Thr Pro Thr Gly Ser Tyr Thr Gln His Gly Pro Leu Phe Ser 
145                 150                 155                 160 


Thr Pro Lys Leu Tyr Ala Val Met Lys Phe Ser Gly Arg Ile Tyr Thr 
                165                 170                 175     


Tyr Ser Gly Thr Thr Pro Asn Ala Thr Thr Gly Tyr Tyr Ser Thr Thr 
            180                 185                 190         


Asn Tyr Asp Thr Val Asn Met Thr Ser Phe Cys Asp Phe Tyr Ile Ile 
        195                 200                 205             


Pro Arg Asn Gln Glu Glu Lys Cys Thr Glu Tyr Ile Asn His Gly Leu 
    210                 215                 220                 


Pro Pro Ile Gln Asn Thr Arg Asn Val Val Pro Val Ser Leu Ser Ala 
225                 230                 235                 240 


Arg Glu Ile Val His Thr Arg 
                245         


<210>  6
<211>  160
<212>  PRT
<213>  Rotavirus

<400>  6

Leu Asp Gly Pro Tyr Gln Pro Thr Thr Phe Asn Pro Pro Thr Ser Tyr 
1               5                   10                  15      


Trp Val Leu Leu Ala Pro Thr Val Glu Gly Val Ile Ile Gln Gly Thr 
            20                  25                  30          


Asn Asn Thr Asp Arg Trp Leu Ala Thr Ile Leu Ile Glu Pro Asn Val 
        35                  40                  45              


Gln Thr Thr Asn Arg Ile Tyr Asn Leu Phe Gly Gln Gln Val Thr Leu 
    50                  55                  60                  


Ser Val Glu Asn Thr Ser Gln Thr Gln Trp Lys Phe Ile Asp Val Ser 
65                  70                  75                  80  


Thr Thr Thr Pro Thr Gly Ser Tyr Thr Gln His Gly Pro Leu Phe Ser 
                85                  90                  95      


Thr Pro Lys Leu Tyr Ala Val Met Lys Phe Ser Gly Arg Ile Tyr Thr 
            100                 105                 110         


Tyr Ser Gly Thr Thr Pro Asn Ala Thr Thr Gly Tyr Tyr Ser Thr Thr 
        115                 120                 125             


Asn Tyr Asp Thr Val Asn Met Thr Ser Phe Cys Asp Phe Tyr Ile Ile 
    130                 135                 140                 


Pro Arg Asn Gln Glu Glu Lys Cys Thr Glu Tyr Ile Asn His Gly Leu 
145                 150                 155                 160 


<210>  7
<211>  168
<212>  PRT
<213>  Rotavirus

<400>  7

Asp Ser Thr Thr Val Glu Pro Leu Leu Asp Gly Pro Tyr Gln Pro Thr 
1               5                   10                  15      


Thr Phe Asn Pro Pro Thr Ser Tyr Trp Val Leu Leu Ala Pro Thr Val 
            20                  25                  30          


Glu Gly Val Ile Ile Gln Gly Thr Asn Asn Thr Asp Arg Trp Leu Ala 
        35                  40                  45              


Thr Ile Leu Ile Glu Pro Asn Val Gln Thr Thr Asn Arg Ile Tyr Asn 
    50                  55                  60                  


Leu Phe Gly Gln Gln Val Thr Leu Ser Val Glu Asn Thr Ser Gln Thr 
65                  70                  75                  80  


Gln Trp Lys Phe Ile Asp Val Ser Thr Thr Thr Pro Thr Gly Ser Tyr 
                85                  90                  95      


Thr Gln His Gly Pro Leu Phe Ser Thr Pro Lys Leu Tyr Ala Val Met 
            100                 105                 110         


Lys Phe Ser Gly Arg Ile Tyr Thr Tyr Ser Gly Thr Thr Pro Asn Ala 
        115                 120                 125             


Thr Thr Gly Tyr Tyr Ser Thr Thr Asn Tyr Asp Thr Val Asn Met Thr 
    130                 135                 140                 


Ser Phe Cys Asp Phe Tyr Ile Ile Pro Arg Asn Gln Glu Glu Lys Cys 
145                 150                 155                 160 


Thr Glu Tyr Ile Asn His Gly Leu 
                165             


<210>  8
<211>  167
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rotavirus consensus sequence

<400>  8

Asp Ser Thr Thr Ile Glu Pro Val Leu Asp Gly Pro Tyr Gln Pro Thr 
1               5                   10                  15      


Ser Phe Lys Pro Pro Asn Asp Tyr Trp Ile Leu Leu Asn Pro Thr Asn 
            20                  25                  30          


Gln Gln Ile Val Leu Glu Gly Thr Asn Arg Thr Asp Val Trp Val Ala 
        35                  40                  45              


Leu Leu Leu Ile Glu Pro Asn Val Thr Asn Gln Ser Arg Gln Tyr Thr 
    50                  55                  60                  


Leu Phe Gly Glu Thr Lys Gln Ile Thr Val Glu Asn Asn Thr Asn Lys 
65                  70                  75                  80  


Trp Lys Phe Phe Glu Met Phe Arg Asn Ser Ala Asn Ala Glu Phe Gln 
                85                  90                  95      


His Lys Arg Thr Leu Thr Ser Asp Thr Lys Leu Ala Gly Phe Leu Lys 
            100                 105                 110         


His Gly Gly Arg Val Trp Thr Phe His Gly Glu Thr Pro Asn Ala Thr 
        115                 120                 125             


Thr Asp Tyr Ser Ser Thr Ser Asn Leu Ser Glu Ile Glu Thr Val Ile 
    130                 135                 140                 


His Thr Glu Phe Tyr Ile Ile Pro Arg Ser Gln Glu Ser Lys Cys Asn 
145                 150                 155                 160 


Glu Tyr Ile Asn Thr Gly Leu 
                165         


<210>  9
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rotavirus consensus sequence

<400>  9

Asp Ser Thr Thr Val Glu Pro Val Leu Asp Gly Pro Tyr Gln Pro Thr 
1               5                   10                  15      


Thr Phe Asn Pro Pro Ile Glu Tyr Trp Thr Leu Phe Ala Pro Asn Asp 
            20                  25                  30          


Lys Gly Val Val Ala Glu Leu Thr Asn Asn Thr Asp Ile Trp Leu Ala 
        35                  40                  45              


Ile Ile Leu Ile Glu Pro Asn Val Pro Gln Glu Leu Arg Thr Tyr Thr 
    50                  55                  60                  


Ile Phe Gly Gln Gln Val Asn Leu Val Ile Glu Asn Thr Ser Gln Thr 
65                  70                  75                  80  


Lys Trp Lys Phe Ala Asp Phe Arg Arg Arg Ser Gln Asn Asp Thr Tyr 
                85                  90                  95      


Val Leu Asn Asp Thr Leu Leu Ser Asp Thr Lys Leu Gln Ala Ala Met 
            100                 105                 110         


Lys Tyr Gly Ala Arg Leu Phe Thr Phe Thr Gly Asp Thr Pro Asn Ala 
        115                 120                 125             


Ala Pro Gln Glu Tyr Gly Tyr Glu Thr Asn Asn Tyr Ser Ala Ile Glu 
    130                 135                 140                 


Ile Arg Ser Phe Cys Asp Phe Tyr Ile Ile Pro Arg Met Pro Arg Glu 
145                 150                 155                 160 


Val Cys Arg Asn Tyr Ile Asn His Gly Leu 
                165                 170 


<210>  10
<211>  181
<212>  PRT
<213>  Rotavirus

<400>  10

Glu Ser Thr Phe Lys Ser Ser Asn Ile Thr Gly Pro His Asn Asn Thr 
1               5                   10                  15      


Val Ile Glu Trp Ser Asn Leu Met Asn Ser Asp Ile Trp Leu Leu Tyr 
            20                  25                  30          


Gln Lys Pro Leu Asp Ile Thr Ala Pro Ile Arg Leu Leu Lys His Gly 
        35                  40                  45              


Pro Glu Asn His Ala Asp Val Ala Ala Phe Glu Leu Trp Tyr Gly Lys 
    50                  55                  60                  


Ala Gly His Thr Val Thr Ser Ile Tyr Tyr Ser Ala Ile Ser Asn Pro 
65                  70                  75                  80  


Asn Asn Thr Val Thr Leu Thr Ser Asp Ser Leu Val Leu Phe Trp Asn 
                85                  90                  95      


Glu Gly Gln Thr Ile Leu Asp Thr Lys Thr Val Asn Phe Asn Trp Asn 
            100                 105                 110         


Met Gly Gly Ile Leu Val Arg Pro Ser Arg Gly Thr Arg Val Asp Ile 
        115                 120                 125             


Cys Met Ser Asp Met Asp Asn Thr Asp Gly Thr Asn Phe Asn Trp Ile 
    130                 135                 140                 


Gln Trp Lys His Glu Phe Pro Arg Ser Ser Ser Asn Ala Asn Val Ser 
145                 150                 155                 160 


Met Tyr Val Glu Tyr Tyr Leu Ala Ser Ser Asp Pro Tyr His Glu Leu 
                165                 170                 175     


Lys Glu Leu Gln Arg 
            180     


<210>  11
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  11

Gly Gly Ser 
1           


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  12

Gly Gly Ser Gly Gly Ser Gly Gly 
1               5               


<210>  13
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  13

Ala Ser Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10  


<210>  14
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  14

Met Thr Tyr Pro Arg Arg Arg Tyr Arg Arg Arg Arg His Arg Pro Arg 
1               5                   10                  15      


Ser His Leu Gly Gln Ile Leu Arg Arg Arg Pro Trp Leu Val His Pro 
            20                  25                  30          


Arg His Arg Tyr Arg Trp Arg Arg Lys Asn Gly Ile Phe Asn Thr Arg 
        35                  40                  45              


Leu Ser Arg Thr Phe Gly Tyr Thr Val Lys Ala Thr Thr Val Thr Thr 
    50                  55                  60                  


Pro Ser Trp Ala Val Asp Met Met Arg Phe Asn Ile Asp Asp Phe Val 
65                  70                  75                  80  


Pro Pro Gly Gly Gly Thr Asn Lys Ile Ser Ile Pro Phe Glu Tyr Tyr 
                85                  90                  95      


Arg Ile Arg Lys Val Lys Val Glu Phe Trp Pro Cys Ser Pro Ile Thr 
            100                 105                 110         


Gln Gly Asp Arg Gly Val Gly Ser Thr Ala Val Ile Leu Asp Asp Asn 
        115                 120                 125             


Phe Val Thr Lys Ala Thr Ala Leu Thr Tyr Asp Pro Tyr Val Asn Tyr 
    130                 135                 140                 


Ser Ser Arg His Thr Ile Pro Gln Pro Phe Ser Tyr His Ser Arg Tyr 
145                 150                 155                 160 


Phe Thr Pro Lys Pro Val Leu Asp Ser Thr Ile Asp Tyr Phe Gln Pro 
                165                 170                 175     


Asn Asn Lys Arg Asn Gln Leu Trp Leu Arg Leu Gln Thr Ser Arg Asn 
            180                 185                 190         


Val Asp His Val Gly Leu Gly Thr Ala Phe Glu Asn Ser Lys Tyr Asp 
        195                 200                 205             


Gln Asp Tyr Asn Ile Arg Val Thr Met Tyr Val Gln Phe Arg Glu Phe 
    210                 215                 220                 


Asn Leu Lys Asp Pro Pro Leu Glu Pro Gly Gly Ser Asp Ser Thr Thr 
225                 230                 235                 240 


Val Glu Pro Leu Leu Asp Gly Pro Tyr Gln Pro Thr Thr Phe Asn Pro 
                245                 250                 255     


Pro Thr Ser Tyr Trp Val Leu Leu Ala Pro Thr Val Glu Gly Val Ile 
            260                 265                 270         


Ile Gln Gly Thr Asn Asn Thr Asp Arg Trp Leu Ala Thr Ile Leu Ile 
        275                 280                 285             


Glu Pro Asn Val Gln Thr Thr Asn Arg Ile Tyr Asn Leu Phe Gly Gln 
    290                 295                 300                 


Gln Val Thr Leu Ser Val Glu Asn Thr Ser Gln Thr Gln Trp Lys Phe 
305                 310                 315                 320 


Ile Asp Val Ser Thr Thr Thr Pro Thr Gly Ser Tyr Thr Gln His Gly 
                325                 330                 335     


Pro Leu Phe Ser Thr Pro Lys Leu Tyr Ala Val Met Lys Phe Ser Gly 
            340                 345                 350         


Arg Ile Tyr Thr Tyr Ser Gly Thr Thr Pro Asn Ala Thr Thr Gly Tyr 
        355                 360                 365             


Tyr Ser Thr Thr Asn Tyr Asp Thr Val Asn Met Thr Ser Phe Cys Asp 
    370                 375                 380                 


Phe Tyr Ile Ile Pro Arg Asn Gln Glu Glu Lys Cys Thr Glu Tyr Ile 
385                 390                 395                 400 


Asn His Gly Leu 
                


<210>  15
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  15

Met Thr Tyr Pro Arg Arg Arg Tyr Arg Arg Arg Arg His Arg Pro Arg 
1               5                   10                  15      


Ser His Leu Gly Gln Ile Leu Arg Arg Arg Pro Trp Leu Val His Pro 
            20                  25                  30          


Arg His Arg Tyr Arg Trp Arg Arg Lys Asn Gly Ile Phe Asn Thr Arg 
        35                  40                  45              


Leu Ser Arg Thr Phe Gly Tyr Thr Val Lys Ala Thr Thr Val Thr Thr 
    50                  55                  60                  


Pro Ser Trp Ala Val Asp Met Met Arg Phe Asn Ile Asp Asp Phe Val 
65                  70                  75                  80  


Pro Pro Gly Gly Gly Thr Asn Lys Ile Ser Ile Pro Phe Glu Tyr Tyr 
                85                  90                  95      


Arg Ile Arg Lys Val Lys Val Glu Phe Trp Pro Cys Ser Pro Ile Thr 
            100                 105                 110         


Gln Gly Asp Arg Gly Val Gly Ser Thr Ala Val Ile Leu Asp Asp Asn 
        115                 120                 125             


Phe Val Thr Lys Ala Thr Ala Leu Thr Tyr Asp Pro Tyr Val Asn Tyr 
    130                 135                 140                 


Ser Ser Arg His Thr Ile Pro Gln Pro Phe Ser Tyr His Ser Arg Tyr 
145                 150                 155                 160 


Phe Thr Pro Lys Pro Val Leu Asp Ser Thr Ile Asp Tyr Phe Gln Pro 
                165                 170                 175     


Asn Asn Lys Arg Asn Gln Leu Trp Leu Arg Leu Gln Thr Ser Arg Asn 
            180                 185                 190         


Val Asp His Val Gly Leu Gly Thr Ala Phe Glu Asn Ser Lys Tyr Asp 
        195                 200                 205             


Gln Asp Tyr Asn Ile Arg Val Thr Met Tyr Val Gln Phe Arg Glu Phe 
    210                 215                 220                 


Asn Leu Lys Asp Pro Pro Leu Glu Pro Gly Gly Ser Asp Ser Thr Thr 
225                 230                 235                 240 


Ile Glu Pro Val Leu Asp Gly Pro Tyr Gln Pro Thr Ser Phe Lys Pro 
                245                 250                 255     


Pro Asn Asp Tyr Trp Ile Leu Leu Asn Pro Thr Asn Gln Gln Ile Val 
            260                 265                 270         


Leu Glu Gly Thr Asn Arg Thr Asp Val Trp Val Ala Leu Leu Leu Ile 
        275                 280                 285             


Glu Pro Asn Val Thr Asn Gln Ser Arg Gln Tyr Thr Leu Phe Gly Glu 
    290                 295                 300                 


Thr Lys Gln Ile Thr Val Glu Asn Asn Thr Asn Lys Trp Lys Phe Phe 
305                 310                 315                 320 


Glu Met Phe Arg Asn Ser Ala Asn Ala Glu Phe Gln His Lys Arg Thr 
                325                 330                 335     


Leu Thr Ser Asp Thr Lys Leu Ala Gly Phe Leu Lys His Gly Gly Arg 
            340                 345                 350         


Val Trp Thr Phe His Gly Glu Thr Pro Asn Ala Thr Thr Asp Tyr Ser 
        355                 360                 365             


Ser Thr Ser Asn Leu Ser Glu Ile Glu Thr Val Ile His Thr Glu Phe 
    370                 375                 380                 


Tyr Ile Ile Pro Arg Ser Gln Glu Ser Lys Cys Asn Glu Tyr Ile Asn 
385                 390                 395                 400 


Thr Gly Leu 
            


<210>  16
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  16

Met Thr Tyr Pro Arg Arg Arg Tyr Arg Arg Arg Arg His Arg Pro Arg 
1               5                   10                  15      


Ser His Leu Gly Gln Ile Leu Arg Arg Arg Pro Trp Leu Val His Pro 
            20                  25                  30          


Arg His Arg Tyr Arg Trp Arg Arg Lys Asn Gly Ile Phe Asn Thr Arg 
        35                  40                  45              


Leu Ser Arg Thr Phe Gly Tyr Thr Val Lys Ala Thr Thr Val Thr Thr 
    50                  55                  60                  


Pro Ser Trp Ala Val Asp Met Met Arg Phe Asn Ile Asp Asp Phe Val 
65                  70                  75                  80  


Pro Pro Gly Gly Gly Thr Asn Lys Ile Ser Ile Pro Phe Glu Tyr Tyr 
                85                  90                  95      


Arg Ile Arg Lys Val Lys Val Glu Phe Trp Pro Cys Ser Pro Ile Thr 
            100                 105                 110         


Gln Gly Asp Arg Gly Val Gly Ser Thr Ala Val Ile Leu Asp Asp Asn 
        115                 120                 125             


Phe Val Thr Lys Ala Thr Ala Leu Thr Tyr Asp Pro Tyr Val Asn Tyr 
    130                 135                 140                 


Ser Ser Arg His Thr Ile Pro Gln Pro Phe Ser Tyr His Ser Arg Tyr 
145                 150                 155                 160 


Phe Thr Pro Lys Pro Val Leu Asp Ser Thr Ile Asp Tyr Phe Gln Pro 
                165                 170                 175     


Asn Asn Lys Arg Asn Gln Leu Trp Leu Arg Leu Gln Thr Ser Arg Asn 
            180                 185                 190         


Val Asp His Val Gly Leu Gly Thr Ala Phe Glu Asn Ser Lys Tyr Asp 
        195                 200                 205             


Gln Asp Tyr Asn Ile Arg Val Thr Met Tyr Val Gln Phe Arg Glu Phe 
    210                 215                 220                 


Asn Leu Lys Asp Pro Pro Leu Glu Pro Gly Gly Ser Asp Ser Thr Thr 
225                 230                 235                 240 


Val Glu Pro Val Leu Asp Gly Pro Tyr Gln Pro Thr Thr Phe Asn Pro 
                245                 250                 255     


Pro Ile Glu Tyr Trp Thr Leu Phe Ala Pro Asn Asp Lys Gly Val Val 
            260                 265                 270         


Ala Glu Leu Thr Asn Asn Thr Asp Ile Trp Leu Ala Ile Ile Leu Ile 
        275                 280                 285             


Glu Pro Asn Val Pro Gln Glu Leu Arg Thr Tyr Thr Ile Phe Gly Gln 
    290                 295                 300                 


Gln Val Asn Leu Val Ile Glu Asn Thr Ser Gln Thr Lys Trp Lys Phe 
305                 310                 315                 320 


Ala Asp Phe Arg Arg Arg Ser Gln Asn Asp Thr Tyr Val Leu Asn Asp 
                325                 330                 335     


Thr Leu Leu Ser Asp Thr Lys Leu Gln Ala Ala Met Lys Tyr Gly Ala 
            340                 345                 350         


Arg Leu Phe Thr Phe Thr Gly Asp Thr Pro Asn Ala Ala Pro Gln Glu 
        355                 360                 365             


Tyr Gly Tyr Glu Thr Asn Asn Tyr Ser Ala Ile Glu Ile Arg Ser Phe 
    370                 375                 380                 


Cys Asp Phe Tyr Ile Ile Pro Arg Met Pro Arg Glu Val Cys Arg Asn 
385                 390                 395                 400 


Tyr Ile Asn His Gly Leu 
                405     


<210>  17
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  17

Met Val Tyr Arg Arg Arg Arg Gly Arg Gly Arg Arg Ala Arg Pro Met 
1               5                   10                  15      


Ser Ser Leu Gly Arg Leu Leu Tyr Arg Lys Pro Trp Leu Met His Pro 
            20                  25                  30          


Arg Phe Arg Ala Arg Tyr Arg Trp Arg Arg Lys Asn Gly Ile Thr Asn 
        35                  40                  45              


Leu Arg Leu Thr Arg Gln Val Glu Leu Trp Val Pro Lys Asp Ala Ala 
    50                  55                  60                  


Asn Ala Ser Phe Tyr Val Asn His Tyr Thr Phe Asp Leu Asp Asp Phe 
65                  70                  75                  80  


Ile Pro Ala Gly Thr Gln Leu Asn Ser Ser Pro Leu Pro Phe Lys Tyr 
                85                  90                  95      


Tyr Arg Ile Arg Lys Val Lys Val Glu Phe Gln Pro Arg Leu Pro Ile 
            100                 105                 110         


Thr Ser Pro Phe Arg Gly Tyr Gly Ser Thr Val Pro Ile Leu Asp Gly 
        115                 120                 125             


Ala Phe Val Thr Pro Ala Thr Gly Glu Ser Asp Pro Ile Trp Asp Pro 
    130                 135                 140                 


Tyr Ile Asn Phe Ser Gly Arg His Val Ile Arg Thr Pro Ala Trp Tyr 
145                 150                 155                 160 


His Lys Arg Tyr Phe Thr Pro Lys Pro Leu Ile Asp Gly Asn Thr Gly 
                165                 170                 175     


Phe Phe Gln Pro Asn Asn Lys Gln Asn Ala Leu Trp Phe Pro Asn Lys 
            180                 185                 190         


Gln Gly Gln Asn Ile Gln Trp Ser Gly Leu Gly Phe Ala Met Gln Lys 
        195                 200                 205             


Gly Asn Glu Ala Tyr Asn Tyr Gln Val Arg Phe Thr Leu Tyr Val Gln 
    210                 215                 220                 


Phe Arg Glu Phe Asp Leu Phe Asn Asn Lys Tyr Thr Ala His Met Asp 
225                 230                 235                 240 


Val Pro Leu Gly Gly Ser Asp Ser Thr Thr Val Glu Pro Leu Leu Asp 
                245                 250                 255     


Gly Pro Tyr Gln Pro Thr Thr Phe Asn Pro Pro Thr Ser Tyr Trp Val 
            260                 265                 270         


Leu Leu Ala Pro Thr Val Glu Gly Val Ile Ile Gln Gly Thr Asn Asn 
        275                 280                 285             


Thr Asp Arg Trp Leu Ala Thr Ile Leu Ile Glu Pro Asn Val Gln Thr 
    290                 295                 300                 


Thr Asn Arg Ile Tyr Asn Leu Phe Gly Gln Gln Val Thr Leu Ser Val 
305                 310                 315                 320 


Glu Asn Thr Ser Gln Thr Gln Trp Lys Phe Ile Asp Val Ser Thr Thr 
                325                 330                 335     


Thr Pro Thr Gly Ser Tyr Thr Gln His Gly Pro Leu Phe Ser Thr Pro 
            340                 345                 350         


Lys Leu Tyr Ala Val Met Lys Phe Ser Gly Arg Ile Tyr Thr Tyr Ser 
        355                 360                 365             


Gly Thr Thr Pro Asn Ala Thr Thr Gly Tyr Tyr Ser Thr Thr Asn Tyr 
    370                 375                 380                 


Asp Thr Val Asn Met Thr Ser Phe Cys Asp Phe Tyr Ile Ile Pro Arg 
385                 390                 395                 400 


Asn Gln Glu Glu Lys Cys Thr Glu Tyr Ile Asn His Gly Leu 
                405                 410                 


<210>  18
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  18

Met Trp Gly Thr Ser Asn Cys Ala Cys Ala Thr Phe Gln Ile Arg Arg 
1               5                   10                  15      


Arg Tyr Ala Arg Pro Tyr Arg Arg Arg His Ile Arg Arg Tyr Arg Arg 
            20                  25                  30          


Arg Arg Arg His Phe Arg Arg Arg Arg Phe Ser Thr Asn Arg Ile Tyr 
        35                  40                  45              


Thr Leu Arg Leu Thr Arg Gln Phe Gln Phe Lys Ile Asn Lys Gln Thr 
    50                  55                  60                  


Thr Ser Val Gly Asn Leu Ile Phe Asn Ala Asp Tyr Ile Thr Phe Ala 
65                  70                  75                  80  


Leu Asp Asp Phe Leu Gln Ala Val Pro Asn Pro His Thr Leu Asn Phe 
                85                  90                  95      


Glu Asp Tyr Arg Ile Lys Leu Ala Lys Met Glu Met Arg Pro Thr Gly 
            100                 105                 110         


Gly His Tyr Thr Val Gln Ser Asp Gly Phe Gly His Thr Ala Val Ile 
        115                 120                 125             


Gln Asp Ser Arg Ile Thr Arg Phe Lys Thr Thr Ala Asp Gln Thr Gln 
    130                 135                 140                 


Asp Pro Leu Ala Pro Phe Asp Gly Ala Lys Lys Trp Phe Val Ser Arg 
145                 150                 155                 160 


Gly Phe Lys Arg Leu Leu Arg Pro Lys Pro Gln Ile Thr Ile Glu Asp 
                165                 170                 175     


Leu Thr Thr Ala Asn Gln Ser Ala Ala Leu Trp Leu Asn Ser Ala Arg 
            180                 185                 190         


Thr Gly Trp Ile Pro Leu Gln Gly Gly Pro Asn Ser Ala Gly Thr Lys 
        195                 200                 205             


Val Arg His Tyr Gly Ile Ala Phe Ser Phe Pro Gln Pro Glu Gln Thr 
    210                 215                 220                 


Ile Thr Tyr Val Thr Lys Leu Thr Leu Tyr Val Gln Phe Arg Gln Phe 
225                 230                 235                 240 


Ala Pro Asn Asn Pro Ser Thr Gly Gly Ser Asp Ser Thr Thr Val Glu 
                245                 250                 255     


Pro Leu Leu Asp Gly Pro Tyr Gln Pro Thr Thr Phe Asn Pro Pro Thr 
            260                 265                 270         


Ser Tyr Trp Val Leu Leu Ala Pro Thr Val Glu Gly Val Ile Ile Gln 
        275                 280                 285             


Gly Thr Asn Asn Thr Asp Arg Trp Leu Ala Thr Ile Leu Ile Glu Pro 
    290                 295                 300                 


Asn Val Gln Thr Thr Asn Arg Ile Tyr Asn Leu Phe Gly Gln Gln Val 
305                 310                 315                 320 


Thr Leu Ser Val Glu Asn Thr Ser Gln Thr Gln Trp Lys Phe Ile Asp 
                325                 330                 335     


Val Ser Thr Thr Thr Pro Thr Gly Ser Tyr Thr Gln His Gly Pro Leu 
            340                 345                 350         


Phe Ser Thr Pro Lys Leu Tyr Ala Val Met Lys Phe Ser Gly Arg Ile 
        355                 360                 365             


Tyr Thr Tyr Ser Gly Thr Thr Pro Asn Ala Thr Thr Gly Tyr Tyr Ser 
    370                 375                 380                 


Thr Thr Asn Tyr Asp Thr Val Asn Met Thr Ser Phe Cys Asp Phe Tyr 
385                 390                 395                 400 


Ile Ile Pro Arg Asn Gln Glu Glu Lys Cys Thr Glu Tyr Ile Asn His 
                405                 410                 415     


Gly Leu 
        


<210>  19
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  19

Met Thr Tyr Pro Arg Arg Arg Tyr Arg Arg Arg Arg His Arg Pro Arg 
1               5                   10                  15      


Ser His Leu Gly Gln Ile Leu Arg Arg Arg Pro Trp Leu Val His Pro 
            20                  25                  30          


Arg His Arg Tyr Arg Trp Arg Arg Lys Asn Gly Ile Phe Asn Thr Arg 
        35                  40                  45              


Leu Ser Arg Thr Phe Gly Tyr Thr Val Lys Ala Thr Thr Val Thr Thr 
    50                  55                  60                  


Pro Ser Trp Ala Val Asp Met Met Arg Phe Asn Ile Asp Asp Phe Val 
65                  70                  75                  80  


Pro Pro Gly Gly Gly Thr Asn Lys Ile Ser Ile Pro Phe Glu Tyr Tyr 
                85                  90                  95      


Arg Ile Arg Lys Val Lys Val Glu Phe Trp Pro Cys Ser Pro Ile Thr 
            100                 105                 110         


Gln Gly Asp Arg Gly Val Gly Ser Thr Ala Val Ile Leu Asp Asp Asn 
        115                 120                 125             


Phe Val Thr Lys Ala Thr Ala Leu Thr Tyr Asp Pro Tyr Val Asn Tyr 
    130                 135                 140                 


Ser Ser Arg His Thr Ile Pro Gln Pro Phe Ser Tyr His Ser Arg Tyr 
145                 150                 155                 160 


Phe Thr Pro Lys Pro Val Leu Asp Ser Thr Ile Asp Tyr Phe Gln Pro 
                165                 170                 175     


Asn Asn Lys Arg Asn Gln Leu Trp Leu Arg Leu Gln Thr Ser Arg Asn 
            180                 185                 190         


Val Asp His Val Gly Leu Gly Thr Ala Phe Glu Asn Ser Lys Tyr Asp 
        195                 200                 205             


Gln Asp Tyr Asn Ile Arg Val Thr Met Tyr Val Gln Phe Arg Glu Phe 
    210                 215                 220                 


Asn Leu Lys Asp Pro Pro Leu Glu Pro Gly Gly Ser Glu Ser Thr Phe 
225                 230                 235                 240 


Lys Ser Ser Asn Ile Thr Gly Pro His Asn Asn Thr Val Ile Glu Trp 
                245                 250                 255     


Ser Asn Leu Met Asn Ser Asp Ile Trp Leu Leu Tyr Gln Lys Pro Leu 
            260                 265                 270         


Asp Ile Thr Ala Pro Ile Arg Leu Leu Lys His Gly Pro Glu Asn His 
        275                 280                 285             


Ala Asp Val Ala Ala Phe Glu Leu Trp Tyr Gly Lys Ala Gly His Thr 
    290                 295                 300                 


Val Thr Ser Ile Tyr Tyr Ser Ala Ile Ser Asn Pro Asn Asn Thr Val 
305                 310                 315                 320 


Thr Leu Thr Ser Asp Ser Leu Val Leu Phe Trp Asn Glu Gly Gln Thr 
                325                 330                 335     


Ile Leu Asp Thr Lys Thr Val Asn Phe Asn Trp Asn Met Gly Gly Ile 
            340                 345                 350         


Leu Val Arg Pro Ser Arg Gly Thr Arg Val Asp Ile Cys Met Ser Asp 
        355                 360                 365             


Met Asp Asn Thr Asp Gly Thr Asn Phe Asn Trp Ile Gln Trp Lys His 
    370                 375                 380                 


Glu Phe Pro Arg Ser Ser Ser Asn Ala Asn Val Ser Met Tyr Val Glu 
385                 390                 395                 400 


Tyr Tyr Leu Ala Ser Ser Asp Pro Tyr His Glu Leu Lys Glu Leu Gln 
                405                 410                 415     


Arg 
    


<210>  20
<211>  427
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  20

Met Val Tyr Arg Arg Arg Arg Gly Arg Gly Arg Arg Ala Arg Pro Met 
1               5                   10                  15      


Ser Ser Leu Gly Arg Leu Leu Tyr Arg Lys Pro Trp Leu Met His Pro 
            20                  25                  30          


Arg Phe Arg Ala Arg Tyr Arg Trp Arg Arg Lys Asn Gly Ile Thr Asn 
        35                  40                  45              


Leu Arg Leu Thr Arg Gln Val Glu Leu Trp Val Pro Lys Asp Ala Ala 
    50                  55                  60                  


Asn Ala Ser Phe Tyr Val Asn His Tyr Thr Phe Asp Leu Asp Asp Phe 
65                  70                  75                  80  


Ile Pro Ala Gly Thr Gln Leu Asn Ser Ser Pro Leu Pro Phe Lys Tyr 
                85                  90                  95      


Tyr Arg Ile Arg Lys Val Lys Val Glu Phe Gln Pro Arg Leu Pro Ile 
            100                 105                 110         


Thr Ser Pro Phe Arg Gly Tyr Gly Ser Thr Val Pro Ile Leu Asp Gly 
        115                 120                 125             


Ala Phe Val Thr Pro Ala Thr Gly Glu Ser Asp Pro Ile Trp Asp Pro 
    130                 135                 140                 


Tyr Ile Asn Phe Ser Gly Arg His Val Ile Arg Thr Pro Ala Trp Tyr 
145                 150                 155                 160 


His Lys Arg Tyr Phe Thr Pro Lys Pro Leu Ile Asp Gly Asn Thr Gly 
                165                 170                 175     


Phe Phe Gln Pro Asn Asn Lys Gln Asn Ala Leu Trp Phe Pro Asn Lys 
            180                 185                 190         


Gln Gly Gln Asn Ile Gln Trp Ser Gly Leu Gly Phe Ala Met Gln Lys 
        195                 200                 205             


Gly Asn Glu Ala Tyr Asn Tyr Gln Val Arg Phe Thr Leu Tyr Val Gln 
    210                 215                 220                 


Phe Arg Glu Phe Asp Leu Phe Asn Asn Lys Tyr Thr Ala His Met Asp 
225                 230                 235                 240 


Val Pro Leu Gly Gly Ser Glu Ser Thr Phe Lys Ser Ser Asn Ile Thr 
                245                 250                 255     


Gly Pro His Asn Asn Thr Val Ile Glu Trp Ser Asn Leu Met Asn Ser 
            260                 265                 270         


Asp Ile Trp Leu Leu Tyr Gln Lys Pro Leu Asp Ile Thr Ala Pro Ile 
        275                 280                 285             


Arg Leu Leu Lys His Gly Pro Glu Asn His Ala Asp Val Ala Ala Phe 
    290                 295                 300                 


Glu Leu Trp Tyr Gly Lys Ala Gly His Thr Val Thr Ser Ile Tyr Tyr 
305                 310                 315                 320 


Ser Ala Ile Ser Asn Pro Asn Asn Thr Val Thr Leu Thr Ser Asp Ser 
                325                 330                 335     


Leu Val Leu Phe Trp Asn Glu Gly Gln Thr Ile Leu Asp Thr Lys Thr 
            340                 345                 350         


Val Asn Phe Asn Trp Asn Met Gly Gly Ile Leu Val Arg Pro Ser Arg 
        355                 360                 365             


Gly Thr Arg Val Asp Ile Cys Met Ser Asp Met Asp Asn Thr Asp Gly 
    370                 375                 380                 


Thr Asn Phe Asn Trp Ile Gln Trp Lys His Glu Phe Pro Arg Ser Ser 
385                 390                 395                 400 


Ser Asn Ala Asn Val Ser Met Tyr Val Glu Tyr Tyr Leu Ala Ser Ser 
                405                 410                 415     


Asp Pro Tyr His Glu Leu Lys Glu Leu Gln Arg 
            420                 425         


<210>  21
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  21

Met Trp Gly Thr Ser Asn Cys Ala Cys Ala Thr Phe Gln Ile Arg Arg 
1               5                   10                  15      


Arg Tyr Ala Arg Pro Tyr Arg Arg Arg His Ile Arg Arg Tyr Arg Arg 
            20                  25                  30          


Arg Arg Arg His Phe Arg Arg Arg Arg Phe Ser Thr Asn Arg Ile Tyr 
        35                  40                  45              


Thr Leu Arg Leu Thr Arg Gln Phe Gln Phe Lys Ile Asn Lys Gln Thr 
    50                  55                  60                  


Thr Ser Val Gly Asn Leu Ile Phe Asn Ala Asp Tyr Ile Thr Phe Ala 
65                  70                  75                  80  


Leu Asp Asp Phe Leu Gln Ala Val Pro Asn Pro His Thr Leu Asn Phe 
                85                  90                  95      


Glu Asp Tyr Arg Ile Lys Leu Ala Lys Met Glu Met Arg Pro Thr Gly 
            100                 105                 110         


Gly His Tyr Thr Val Gln Ser Asp Gly Phe Gly His Thr Ala Val Ile 
        115                 120                 125             


Gln Asp Ser Arg Ile Thr Arg Phe Lys Thr Thr Ala Asp Gln Thr Gln 
    130                 135                 140                 


Asp Pro Leu Ala Pro Phe Asp Gly Ala Lys Lys Trp Phe Val Ser Arg 
145                 150                 155                 160 


Gly Phe Lys Arg Leu Leu Arg Pro Lys Pro Gln Ile Thr Ile Glu Asp 
                165                 170                 175     


Leu Thr Thr Ala Asn Gln Ser Ala Ala Leu Trp Leu Asn Ser Ala Arg 
            180                 185                 190         


Thr Gly Trp Ile Pro Leu Gln Gly Gly Pro Asn Ser Ala Gly Thr Lys 
        195                 200                 205             


Val Arg His Tyr Gly Ile Ala Phe Ser Phe Pro Gln Pro Glu Gln Thr 
    210                 215                 220                 


Ile Thr Tyr Val Thr Lys Leu Thr Leu Tyr Val Gln Phe Arg Gln Phe 
225                 230                 235                 240 


Ala Pro Asn Asn Pro Ser Thr Gly Gly Ser Glu Ser Thr Phe Lys Ser 
                245                 250                 255     


Ser Asn Ile Thr Gly Pro His Asn Asn Thr Val Ile Glu Trp Ser Asn 
            260                 265                 270         


Leu Met Asn Ser Asp Ile Trp Leu Leu Tyr Gln Lys Pro Leu Asp Ile 
        275                 280                 285             


Thr Ala Pro Ile Arg Leu Leu Lys His Gly Pro Glu Asn His Ala Asp 
    290                 295                 300                 


Val Ala Ala Phe Glu Leu Trp Tyr Gly Lys Ala Gly His Thr Val Thr 
305                 310                 315                 320 


Ser Ile Tyr Tyr Ser Ala Ile Ser Asn Pro Asn Asn Thr Val Thr Leu 
                325                 330                 335     


Thr Ser Asp Ser Leu Val Leu Phe Trp Asn Glu Gly Gln Thr Ile Leu 
            340                 345                 350         


Asp Thr Lys Thr Val Asn Phe Asn Trp Asn Met Gly Gly Ile Leu Val 
        355                 360                 365             


Arg Pro Ser Arg Gly Thr Arg Val Asp Ile Cys Met Ser Asp Met Asp 
    370                 375                 380                 


Asn Thr Asp Gly Thr Asn Phe Asn Trp Ile Gln Trp Lys His Glu Phe 
385                 390                 395                 400 


Pro Arg Ser Ser Ser Asn Ala Asn Val Ser Met Tyr Val Glu Tyr Tyr 
                405                 410                 415     


Leu Ala Ser Ser Asp Pro Tyr His Glu Leu Lys Glu Leu Gln Arg 
            420                 425                 430     


<210>  22
<211>  1215
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  encodes a fusion protein

<400>  22
atgacgtatc caaggaggcg ttaccgcaga agaagacacc gcccccgcag ccatcttggc       60

cagatcctcc gccgccgccc ctggctcgtc cacccccgcc accgctaccg ttggagaagg      120

aaaaatggca tcttcaacac ccgcctctcc cgcaccttcg gatatactgt caaggctacc      180

acagtcacaa cgccctcctg ggcggtggac atgatgagat ttaatattga cgactttgtt      240

cccccgggag gggggaccaa caaaatctct ataccctttg aatactacag aataagaaag      300

gttaaggttg aattctggcc ctgctccccc atcacccagg gtgatagggg agtgggctcc      360

actgctgtta ttctagatga taactttgta acaaaggcca cagccctaac ctatgaccca      420

tatgtaaact actcctcccg ccatacaatc ccccaaccct tctcctacca ctcccgttac      480

ttcacaccca aacctgttct tgactccact attgattact tccaaccaaa taacaaaagg      540

aatcagcttt ggctgaggct acaaacctct agaaatgtgg accacgtagg cctcggcact      600

gcgttcgaaa acagtaaata cgaccaggac tacaatatcc gtgtaaccat gtatgtacaa      660

ttcagagaat ttaatcttaa agacccccca cttgaacccg gcggctcgga tagtaccaca      720

gtagaaccac tgttggacgg cccctaccaa cctactacgt ttaacccccc aacctcatac      780

tgggtgttgc tcgcgcctac agtcgagggt gtcataatcc aaggtacgaa taacaccgat      840

cgctggttgg ctactatcct tattgaaccg aatgttcaga ccacaaatcg catttacaac      900

ttgttcggac agcaggtgac cctttcagtt gagaacacga gtcaaaccca atggaaattt      960

atcgacgttt ctaccacaac acctaccggc agctatacgc aacacggccc actctttagc     1020

acccctaagc tgtatgcagt aatgaagttt agcggacgca tttacacata ctcaggtaca     1080

actcctaatg ctactacggg ctactatagc actactaatt atgatacggt gaatatgaca     1140

agtttctgtg atttctacat catccccaga aaccaggagg agaaatgtac tgaatatata     1200

aatcatggac tgtga                                                      1215


<210>  23
<211>  1212
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  encodes a fusion protein

<400>  23
atgacgtacc ctcggaggag gtatcgtcgg agacgacatc gaccacgctc tcacttggga       60

caaatactga ggcggcgacc gtggttggtc catccgcggc atcgttatcg ctggaggcgt      120

aagaacggta tattcaacac gcgcttatcg cggacattcg gctacacggt taaagcgaca      180

actgttacga ccccttcctg ggcagtcgat atgatgaggt tcaacatcga cgactttgtg      240

ccccctggcg gaggtactaa taagatatcg attccattcg agtattatcg aataagaaag      300

gtaaaagtgg agttctggcc gtgctcccca ataacccagg gtgatcgcgg ggtaggaagt      360

accgccgtca tcctcgatga caactttgtg acgaaagcga cagctttaac ttacgaccct      420

tatgtgaatt actcctctag acatactatc ccacagcctt ttagctacca ttcaagatat      480

tttacaccta agccagtatt ggattctacc atcgactatt tccagccaaa caataagcgt      540

aaccaactgt ggttacggct ccagacatca cgaaacgtag accacgtagg cctggggacc      600

gcatttgaga actcaaaata tgatcaagat tacaacatcc gcgtcaccat gtacgttcag      660

tttagggaat ttaatctaaa agatccgccc ttggaaccgg gtgggagtga ctccaccact      720

attgagcccg ttctcgacgg cccttatcag ccgacatcat ttaaaccgcc aaacgactat      780

tggattcttc ttaatcccac caatcaacaa atagttctag aaggaacaaa tcgcacagat      840

gtgtgggtcg ccctgttact aattgaaccc aacgttacta accaatctcg tcaatacaca      900

cttttcgggg aaacaaagca gattaccgta gagaacaata ctaataaatg gaagttcttt      960

gaaatgttta gaaattcggc taacgctgag ttccagcaca aacgtactct aacgtctgat     1020

acgaagcttg ccggtttcct taaacacggg ggacgagtct ggacctttca cggcgaaact     1080

cccaatgcga caaccgacta cagcagcacc tcgaatctca gtgagattga gacggtgatc     1140

cacactgagt tctatattat acccagaagc caagaaagta agtgtaatga atacatcaat     1200

acgggcctct ga                                                         1212


<210>  24
<211>  1221
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  encodes a fusion protein

<400>  24
atgacttatc cgcgccgacg atatcgccga agaaggcata gaccgcggtc tcatctagga       60

caaatattgc ggcgccgccc atggttggta catcctcgtc atcgataccg ctggcggagg      120

aagaacggca tctttaatac taggctctcc cgaacgttcg ggtatacagt caaggctact      180

acagtcacca caccgagttg ggcagtggac atgatgcgtt ttaatatcga cgatttcgta      240

cctcccggtg ggggtactaa taaaatatcc attcccttcg agtactacag gatacgcaaa      300

gttaaggtgg aattttggcc ttgttcgcca attacgcaag gcgatagagg ggtcggctcg      360

accgccgtga ttctcgacga caacttcgtt acaaaagcta ctgcgttaac atatgatcca      420

tacgtcaact actcttcaag acacacgata cctcaaccat tttcctacca cagccgttat      480

ttcactccta agcccgtact agactccaca atagactact tccagcctaa taataagaga      540

aaccagttat ggcttagact tcaaacctca cggaacgttg accacgttgg cctaggcacg      600

gcctttgaga atagtaaata tgatcaggac tataacatcc gtgtaacgat gtacgtacag      660

tttcgcgagt ttaaccttaa agaccccccc ctcgagcccg gaggatcaga tagcacgaca      720

gttgaaccgg tgctggatgg gccatatcag cctaccacgt tcaatccacc aattgaatac      780

tggaccctct tcgcgccgaa cgacaaaggt gtggtagctg agttaactaa taatactgac      840

atctggttgg ctatcatcct gattgaacca aatgttccgc aggaattgcg tacctatact      900

attttcgggc agcaagtaaa ccttgtcata gagaatacaa gtcaaaccaa atggaagttt      960

gccgatttta gacgtcggtc tcagaatgat acgtatgtcc tgaatgatac gttactatct     1020

gatacaaaac tgcaagccgc aatgaagtat ggagcaaggc tatttacttt tactggagat     1080

accccgaatg cggcgccgca agaatatggt tacgaaacga ataactatag cgcaatagag     1140

attaggtcgt tttgtgactt ctacatcatt cccaggatgc ctcgggaagt gtgccgaaac     1200

tacataaacc acggtctttg a                                               1221


<210>  25
<211>  1245
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  encodes fusion protein

<400>  25
atggtgtaca ggaggaggag aggacgcggt cgcagggctc gtccaatgtc cagcctggga       60

cgcctgctgt accgtaagcc ttggctgatg cacccccgct tccgtgccag gtacagatgg      120

aggagaaaga acggtatcac taacctgagg ctgaccagac aggtggagct gtgggtccca      180

aaggacgctg ccaacgcttc cttctacgtg aaccactaca ctttcgacct ggacgacttc      240

atccctgccg gaacccagct gaactcttca ccactgcctt tcaagtacta ccgcatccgt      300

aaggtgaagg tcgagttcca gcctaggctg cccatcactt cccccttcag aggctacgga      360

agcaccgtgc caatcctgga cggcgctttc gtcactcctg ccaccggaga atctgacccc      420

atctgggacc catacatcaa cttctcaggc aggcacgtca tcagaacccc tgcttggtac      480

cacaagcgct acttcactcc caagccactg atcgacggaa acaccggttt cttccagccc      540

aacaacaagc agaacgccct gtggttccca aacaagcagg gtcagaacat ccagtggtct      600

ggtctgggct tcgctatgca gaagggcaac gaggcctaca actaccaggt gcgcttcact      660

ctgtacgtcc agttccgtga attcgacctg ttcaacaaca agtacaccgc tcacatggac      720

gtgcctctgg gtggctccga cagcaccact gtcgagcccc tgctggacgg tccataccag      780

cctaccactt tcaaccctcc cacttcatac tgggtgctgc tggctccaac tgtggagggc      840

gtcatcatcc agggaactaa caacaccgac aggtggctgg ccactatcct gatcgaacca      900

aacgtccaga ccactaacag aatctacaac ctgttcggcc agcaggtgac cctgtctgtc      960

gaaaacactt cacagaccca gtggaagttc atcgacgtgt ctaccactac ccccactggt     1020

tcatacaccc agcacggccc actgttcagc actcctaagc tgtacgctgt catgaagttc     1080

tccggacgta tctacaccta cagcggtact acccctaacg ccactaccgg ctactactcc     1140

actaccaact acgacactgt gaacatgacc agcttctgcg acttctacat catccccagg     1200

aaccaggagg aaaagtgcac cgaatacatc aaccacggac tgtaa                     1245


<210>  26
<211>  1257
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  encodes fusion protein

<400>  26
atgtggggca cttccaactg cgcttgcgcc accttccaga tccgccgtcg ttacgctcgt       60

ccttacagac gccgtcacat caggagatac cgccgtagga gacgccactt ccgtaggaga      120

cgcttctcca ccaacaggat ctacactctg cgtctgacca ggcagttcca gttcaagatc      180

aacaagcaga ccactagcgt gggaaacctg atcttcaacg ctgactacat caccttcgcc      240

ctggacgact tcctgcaggc tgtcccaaac cctcacactc tgaacttcga ggactacaga      300

atcaagctgg ccaagatgga aatgcgcccc actggtggcc actacaccgt gcagtccgac      360

ggtttcggcc acactgctgt catccaggac agcagaatca cccgcttcaa gaccactgcc      420

gaccagactc aggacccact ggctcctttc gacggcgcca agaagtggtt cgtgagccgc      480

ggattcaagc gtctgctgag gcccaagcca cagatcacca tcgaggacct gaccactgct      540

aaccagtccg ctgccctgtg gctgaacagc gccagaaccg gttggattcc tctgcaggga      600

ggtcctaact ctgctggtac taaggtccgc cactacggca tcgccttctc attccctcag      660

cccgagcaga ctatcaccta cgtgactaag ctgaccctgt acgtccagtt ccgtcagttc      720

gcccccaaca acccatctac cggtggttcc gacagcacca ctgtggaacc tctgctggac      780

ggaccttacc agcccaccac tttcaaccct cccacctcat actgggtcct gctggctccc      840

actgtggagg gagtcatcat ccagggtact aacaacaccg accgttggct ggccaccatc      900

ctgatcgaac ccaacgtgca gaccactaac aggatctaca acctgttcgg tcagcaagtg      960

actctgtctg tcgagaacac ttcacagacc cagtggaagt tcatcgacgt gtctaccact     1020

accccaactg gctcatacac ccagcacgga cccctgttct ccaccccaaa gctgtacgct     1080

gtcatgaagt tctccggacg tatctacact tacagcggta ctaccccaaa cgccactacc     1140

ggttactact ctactaccaa ctacgacact gtcaacatga cctcattctg cgacttctac     1200

atcatccctc gcaaccagga ggaaaagtgc accgaataca tcaaccacgg cctgtaa        1257


<210>  27
<211>  1254
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  encodes a fusion protein

<400>  27
atgacgtatc caaggaggcg ttaccgcaga agaagacacc gcccccgcag ccatcttggc       60

cagatcctcc gccgccgccc ctggctcgtc cacccccgcc accgctaccg ttggagaagg      120

aaaaatggca tcttcaacac ccgcctctcc cgcaccttcg gatatactgt caaggctacc      180

acagtcacaa cgccctcctg ggcggtggac atgatgagat ttaatattga cgactttgtt      240

cccccgggag gggggaccaa caaaatctct ataccctttg aatactacag aataagaaag      300

gttaaggttg aattctggcc ctgctccccc atcacccagg gtgatagggg agtgggctcc      360

actgctgtta ttctagatga taactttgta acaaaggcca cagccctaac ctatgaccca      420

tatgtaaact actcctcccg ccatacaatc ccccaaccct tctcctacca ctcccgttac      480

ttcacaccca aacctgttct tgactccact attgattact tccaaccaaa taacaaaagg      540

aatcagcttt ggctgaggct acaaacctct agaaatgtgg accacgtagg cctcggcact      600

gcgttcgaaa acagtaaata cgaccaggac tacaatatcc gtgtaaccat gtatgtacaa      660

ttcagagaat ttaatcttaa agacccccca cttgaacccg gcggctcgga atctacattc      720

aaatcatcaa atataactgg tccacacaat aacacagtca ttgaatggag taatttaatg      780

aattctgata tttggttatt gtatcaaaaa ccattggata taactgcacc aatcagatta      840

ttaaaacatg gaccggaaaa tcatgctgat gtagcagctt ttgaattatg gtatggtaaa      900

gctggtcata ccgtgacatc aatatattat tcagcaatat ctaatcctaa taatactgtt      960

acgttaacgt cggattcatt agttctattt tggaacgaag gtcaaacgat actggataca     1020

aagacagtca attttaattg gaatatgggt ggtatattag ttagaccgtc aagaggtaca     1080

cgtgtggaca tttgtatgtc tgatatggac aatacagatg gtactaattt taattggatt     1140

caatggaagc atgagttccc ccgtagtagt agtaatgcta atgttagtat gtatgttgaa     1200

tattatctag caagtagtga tccataccat gaactcaaag agttgcaaag atga           1254


<210>  28
<211>  1284
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  encodes fusion protein

<400>  28
atggtgtatc gccgccgacg agggagggga agacgggccc ggcccatgag cagcttaggg       60

cgtcttctgt atcgaaagcc gtggctcatg catccacgtt ttagggctcg atataggtgg      120

cgccgaaaaa acggcataac taacctccgc cttactagac aggttgagtt gtgggttcct      180

aaggatgcgg caaacgcgag cttctacgtc aaccattaca catttgactt agatgatttc      240

attccggccg gaactcaatt gaactccagc ccactaccct tcaaatatta taggattcga      300

aaagttaaag tagagttcca gcccaggcta cctattacct ctccctttag aggttacggc      360

tccaccgtcc ccatattaga cggtgccttc gttacccctg caaccggtga gtccgatcct      420

atatgggatc cgtacataaa cttcagtggg cgtcatgtaa taagaacccc agcctggtat      480

cataagagat attttacgcc gaagccactg attgatggaa atactgggtt cttccagcct      540

aataacaagc aaaacgctct ctggttccca aacaagcaag ggcagaacat acagtggtca      600

ggtctcggtt ttgccatgca aaaggggaac gaggcttata attaccaggt ccgtttcaca      660

ctttacgtac aatttcgcga atttgatctg tttaataaca agtatacggc gcacatggac      720

gtccctttag gcggatcaga atctactttt aaatcttcta acatcacagg cccccataac      780

aatacggtga tcgaatggtc gaatttgatg aactcggaca tctggctact ttaccaaaaa      840

ccactagata taacggcacc cattagactc ctaaaacacg ggccggagaa tcacgctgat      900

gtggctgcat ttgaattatg gtacggcaag gccggtcaca cggtgaccag tatctactat      960

tccgcgattt cgaatccgaa caatacggtc acacttacat ccgatagtct tgtactcttt     1020

tggaatgaag gacaaacaat cttggacacg aaaaccgtaa actttaattg gaatatgggc     1080

ggtattctgg ttcgcccaag ccgtggaact cgggtcgaca tctgcatgtc agacatggac     1140

aatactgacg gcacaaattt taattggatc caatggaaac acgaatttcc tcggtcgtct     1200

agtaatgcga atgtgtcaat gtacgttgaa tattatttgg catcgtcaga tccgtaccac     1260

gagctgaagg agttgcagcg gtga                                            1284


<210>  29
<211>  1296
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  encodes fusion protein

<400>  29
atgtggggga cttccaattg cgcgtgcgct acgtttcaga ttaggaggag gtacgcacgc       60

ccataccggc gtcgacacat tagacggtat agaagacgac gtcgccactt caggcgtagg      120

aggtttagca caaatcgaat ttatacgcta cgcctcactc gacaattcca atttaagatc      180

aataagcaaa ccacgagcgt agggaactta atatttaacg cagattacat tacatttgct      240

ctggatgact ttttacaggc ggtgccaaac ccccatactc tgaatttcga ggattatcga      300

atcaaactgg cgaagatgga aatgcgcccg accggtggac attacacagt ccagtcagac      360

ggtttcggtc acacagctgt catccaagac agtagaatca cccgattcaa gacgacggcc      420

gatcaaaccc aggatcccct tgccccattc gatggggcaa agaagtggtt cgtgtcacgg      480

ggtttcaaac gcctgctccg gccgaagcct cagataacga tagaggactt aaccaccgcg      540

aaccaatctg cggcactatg gctcaatagt gcccggactg gctggattcc tctacaggga      600

ggaccgaact ctgcggggac taaagtacgt cattatggaa tcgcattctc ttttccgcaa      660

ccagagcaga ccataacata cgtaacaaaa ctcactctct acgtacagtt ccggcaattt      720

gctcccaaca acccatcgac aggtggctca gagtcgacat ttaagtcatc gaatatcact      780

ggacctcata acaatactgt gattgaatgg agcaatttga tgaactctga catttggcta      840

ctttatcaaa aacctcttga cataacggct ccgataagat tattgaaaca cggcccagaa      900

aaccatgctg acgtggcggc ctttgaattg tggtacggga aggcagggca cacagtaact      960

agcatctatt attcagcaat ctcgaacccc aataataccg tcacccttac atccgattcc     1020

ctagttctgt tctggaatga gggccagacc attcttgaca ctaaaaccgt taacttcaat     1080

tggaacatgg gcggcatatt agttcgtccc agtcggggta cacgcgtcga tatatgtatg     1140

agtgacatgg ataatacgga cggaacgaat tttaactgga ttcagtggaa acacgaattt     1200

cctcgttcct cctcgaatgc caacgttagc atgtacgtcg agtattattt ggccagttct     1260

gatccctacc atgaactaaa agaattgcaa agatga                               1296


<210>  30
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  30
gctagggaya aaattgttga aggta                                             25


<210>  31
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  31
attggcaaat ttcctattcc tcc                                               23


<210>  32
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe sequence

<400>  32
atgaatggaa atgaytttca aac                                               23


<210>  33
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe sequence

<400>  33
atgaatggaa ataattttca aac                                               23


