                         SEQUENCE LISTING

<110>  The General Hospital Corporation, Christian Joseph Freniere, and Qiong Ye
 
<120>  PEPTIDE INHIBITORS OF GLIOMA-ASSOCIATED ONCOGENE DERIVED FROM THE COILED-COIL DIMERIZATION DOMAIN OF Kif7 

<130>  51545-002WO2

<150>  US 63/089,770
<151>  2020-10-09

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  1343
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Leu Glu Ala Gln Arg Leu Pro Gly Ala Glu Glu Ala Pro Val 
1               5                   10                  15      


Arg Val Ala Leu Arg Val Arg Pro Leu Leu Pro Lys Glu Leu Leu His 
            20                  25                  30          


Gly His Gln Ser Cys Leu Gln Val Glu Pro Gly Leu Gly Arg Val Thr 
        35                  40                  45              


Leu Gly Arg Asp Arg His Phe Gly Phe His Val Val Leu Ala Glu Asp 
    50                  55                  60                  


Ala Gly Gln Glu Ala Val Tyr Gln Ala Cys Val Gln Pro Leu Leu Glu 
65                  70                  75                  80  


Ala Phe Phe Glu Gly Phe Asn Ala Thr Val Phe Ala Tyr Gly Gln Thr 
                85                  90                  95      


Gly Ser Gly Lys Thr Tyr Thr Met Gly Glu Ala Ser Val Ala Ser Leu 
            100                 105                 110         


Leu Glu Asp Glu Gln Gly Ile Val Pro Arg Ala Met Ala Glu Ala Phe 
        115                 120                 125             


Lys Leu Ile Asp Glu Asn Asp Leu Leu Asp Cys Leu Val His Val Ser 
    130                 135                 140                 


Tyr Leu Glu Val Tyr Lys Glu Glu Phe Arg Asp Leu Leu Glu Val Gly 
145                 150                 155                 160 


Thr Ala Ser Arg Asp Ile Gln Leu Arg Glu Asp Glu Arg Gly Asn Val 
                165                 170                 175     


Val Leu Cys Gly Val Lys Glu Val Asp Val Glu Gly Leu Asp Glu Val 
            180                 185                 190         


Leu Ser Leu Leu Glu Met Gly Asn Ala Ala Arg His Thr Gly Ala Thr 
        195                 200                 205             


His Leu Asn His Leu Ser Ser Arg Ser His Thr Val Phe Thr Val Thr 
    210                 215                 220                 


Leu Glu Gln Arg Gly Arg Ala Pro Ser Arg Leu Pro Arg Pro Ala Pro 
225                 230                 235                 240 


Gly Gln Leu Leu Val Ser Lys Phe His Phe Val Asp Leu Ala Gly Ser 
                245                 250                 255     


Glu Arg Val Leu Lys Thr Gly Ser Thr Gly Glu Arg Leu Lys Glu Ser 
            260                 265                 270         


Ile Gln Ile Asn Ser Ser Leu Leu Ala Leu Gly Asn Val Ile Ser Ala 
        275                 280                 285             


Leu Gly Asp Pro Gln Arg Arg Gly Ser His Ile Pro Tyr Arg Asp Ser 
    290                 295                 300                 


Lys Ile Thr Arg Ile Leu Lys Asp Ser Leu Gly Gly Asn Ala Lys Thr 
305                 310                 315                 320 


Val Met Ile Ala Cys Val Ser Pro Ser Ser Ser Asp Phe Asp Glu Thr 
                325                 330                 335     


Leu Asn Thr Leu Asn Tyr Ala Ser Arg Ala Gln Asn Ile Arg Asn Arg 
            340                 345                 350         


Ala Thr Val Asn Trp Arg Pro Glu Ala Glu Arg Pro Pro Glu Glu Thr 
        355                 360                 365             


Ala Ser Gly Ala Arg Gly Pro Pro Arg His Arg Ser Glu Thr Arg Ile 
    370                 375                 380                 


Ile His Arg Gly Arg Arg Ala Pro Gly Pro Ala Thr Ala Ser Ala Ala 
385                 390                 395                 400 


Ala Ala Met Arg Leu Gly Ala Glu Cys Ala Arg Tyr Arg Ala Cys Thr 
                405                 410                 415     


Asp Ala Ala Tyr Ser Leu Leu Arg Glu Leu Gln Ala Glu Pro Gly Leu 
            420                 425                 430         


Pro Gly Ala Ala Ala Arg Lys Val Arg Asp Trp Leu Cys Ala Val Glu 
        435                 440                 445             


Gly Glu Arg Ser Ala Leu Ser Ser Ala Ser Gly Pro Asp Ser Gly Ile 
    450                 455                 460                 


Glu Ser Ala Ser Val Glu Asp Gln Ala Ala Gln Gly Ala Gly Gly Arg 
465                 470                 475                 480 


Lys Glu Asp Glu Gly Ala Gln Gln Leu Leu Thr Leu Gln Asn Gln Val 
                485                 490                 495     


Ala Arg Leu Glu Glu Glu Asn Arg Asp Phe Leu Ala Ala Leu Glu Asp 
            500                 505                 510         


Ala Met Glu Gln Tyr Lys Leu Gln Ser Asp Arg Leu Arg Glu Gln Gln 
        515                 520                 525             


Glu Glu Met Val Glu Leu Arg Leu Arg Leu Glu Leu Val Arg Pro Gly 
    530                 535                 540                 


Trp Gly Gly Pro Arg Leu Leu Asn Gly Leu Pro Pro Gly Ser Phe Val 
545                 550                 555                 560 


Pro Arg Pro His Thr Ala Pro Leu Gly Gly Ala His Ala His Val Leu 
                565                 570                 575     


Gly Met Val Pro Pro Ala Cys Leu Pro Gly Asp Glu Val Gly Ser Glu 
            580                 585                 590         


Gln Arg Gly Glu Gln Val Thr Asn Gly Arg Glu Ala Gly Ala Glu Leu 
        595                 600                 605             


Leu Thr Glu Val Asn Arg Leu Gly Ser Gly Ser Ser Ala Ala Ser Glu 
    610                 615                 620                 


Glu Glu Glu Glu Glu Glu Glu Pro Pro Arg Arg Thr Leu His Leu Arg 
625                 630                 635                 640 


Arg Asn Arg Ile Ser Asn Cys Ser Gln Arg Ala Gly Ala Arg Pro Gly 
                645                 650                 655     


Ser Leu Pro Glu Arg Lys Gly Pro Glu Leu Cys Leu Glu Glu Leu Asp 
            660                 665                 670         


Ala Ala Ile Pro Gly Ser Arg Ala Val Gly Gly Ser Lys Ala Arg Val 
        675                 680                 685             


Gln Ala Arg Gln Val Pro Pro Ala Thr Ala Ser Glu Trp Arg Leu Ala 
    690                 695                 700                 


Gln Ala Gln Gln Lys Ile Arg Glu Leu Ala Ile Asn Ile Arg Met Lys 
705                 710                 715                 720 


Glu Glu Leu Ile Gly Glu Leu Val Arg Thr Gly Lys Ala Ala Gln Ala 
                725                 730                 735     


Leu Asn Arg Gln His Ser Gln Arg Ile Arg Glu Leu Glu Gln Glu Ala 
            740                 745                 750         


Glu Gln Val Arg Ala Glu Leu Ser Glu Gly Gln Arg Gln Leu Arg Glu 
        755                 760                 765             


Leu Glu Gly Lys Glu Leu Gln Asp Ala Gly Glu Arg Ser Arg Leu Gln 
    770                 775                 780                 


Glu Phe Arg Arg Arg Val Ala Ala Ala Gln Ser Gln Val Gln Val Leu 
785                 790                 795                 800 


Lys Glu Lys Lys Gln Ala Thr Glu Arg Leu Val Ser Leu Ser Ala Gln 
                805                 810                 815     


Ser Glu Lys Arg Leu Gln Glu Leu Glu Arg Asn Val Gln Leu Met Arg 
            820                 825                 830         


Gln Gln Gln Gly Gln Leu Gln Arg Arg Leu Arg Glu Glu Thr Glu Gln 
        835                 840                 845             


Lys Arg Arg Leu Glu Ala Glu Met Ser Lys Arg Gln His Arg Val Lys 
    850                 855                 860                 


Glu Leu Glu Leu Lys His Glu Gln Gln Gln Lys Ile Leu Lys Ile Lys 
865                 870                 875                 880 


Thr Glu Glu Ile Ala Ala Phe Gln Arg Lys Arg Arg Ser Gly Ser Asn 
                885                 890                 895     


Gly Ser Val Val Ser Leu Glu Gln Gln Gln Lys Ile Glu Glu Gln Lys 
            900                 905                 910         


Lys Trp Leu Asp Gln Glu Met Glu Lys Val Leu Gln Gln Arg Arg Ala 
        915                 920                 925             


Leu Glu Glu Leu Gly Glu Glu Leu His Lys Arg Glu Ala Ile Leu Ala 
    930                 935                 940                 


Lys Lys Glu Ala Leu Met Gln Glu Lys Thr Gly Leu Glu Ser Lys Arg 
945                 950                 955                 960 


Leu Arg Ser Ser Gln Ala Leu Asn Glu Asp Ile Val Arg Val Ser Ser 
                965                 970                 975     


Arg Leu Glu His Leu Glu Lys Glu Leu Ser Glu Lys Ser Gly Gln Leu 
            980                 985                 990         


Arg Gln Gly Ser Ala Gln Ser Gln  Gln Gln Ile Arg Gly  Glu Ile Asp 
        995                 1000                 1005             


Ser Leu  Arg Gln Glu Lys Asp  Ser Leu Leu Lys Gln  Arg Leu Glu 
    1010                 1015                 1020             


Ile Asp  Gly Lys Leu Arg Gln  Gly Ser Leu Leu Ser  Pro Glu Glu 
    1025                 1030                 1035             


Glu Arg  Thr Leu Phe Gln Leu  Asp Glu Ala Ile Glu  Ala Leu Asp 
    1040                 1045                 1050             


Ala Ala  Ile Glu Tyr Lys Asn  Glu Ala Ile Thr Cys  Arg Gln Arg 
    1055                 1060                 1065             


Val Leu  Arg Ala Ser Ala Ser  Leu Leu Ser Gln Cys  Glu Met Asn 
    1070                 1075                 1080             


Leu Met  Ala Lys Leu Ser Tyr  Leu Ser Ser Ser Glu  Thr Arg Ala 
    1085                 1090                 1095             


Leu Leu  Cys Lys Tyr Phe Asp  Lys Val Val Thr Leu  Arg Glu Glu 
    1100                 1105                 1110             


Gln His  Gln Gln Gln Ile Ala  Phe Ser Glu Leu Glu  Met Gln Leu 
    1115                 1120                 1125             


Glu Glu  Gln Gln Arg Leu Val  Tyr Trp Leu Glu Val  Ala Leu Glu 
    1130                 1135                 1140             


Arg Gln  Arg Leu Glu Met Asp  Arg Gln Leu Thr Leu  Gln Gln Lys 
    1145                 1150                 1155             


Glu His  Glu Gln Asn Met Gln  Leu Leu Leu Gln Gln  Ser Arg Asp 
    1160                 1165                 1170             


His Leu  Gly Glu Gly Leu Ala  Asp Ser Arg Arg Gln  Tyr Glu Ala 
    1175                 1180                 1185             


Arg Ile  Gln Ala Leu Glu Lys  Glu Leu Gly Arg Tyr  Met Trp Ile 
    1190                 1195                 1200             


Asn Gln  Glu Leu Lys Gln Lys  Leu Gly Gly Val Asn  Ala Val Gly 
    1205                 1210                 1215             


His Ser  Arg Gly Gly Glu Lys  Arg Ser Leu Cys Ser  Glu Gly Arg 
    1220                 1225                 1230             


Gln Ala  Pro Gly Asn Glu Asp  Glu Leu His Leu Ala  Pro Glu Leu 
    1235                 1240                 1245             


Leu Trp  Leu Ser Pro Leu Thr  Glu Gly Ala Pro Arg  Thr Arg Glu 
    1250                 1255                 1260             


Glu Thr  Arg Asp Leu Val His  Ala Pro Leu Pro Leu  Thr Trp Lys 
    1265                 1270                 1275             


Arg Ser  Ser Leu Cys Gly Glu  Glu Gln Gly Ser Pro  Glu Glu Leu 
    1280                 1285                 1290             


Arg Gln  Arg Glu Ala Ala Glu  Pro Leu Val Gly Arg  Val Leu Pro 
    1295                 1300                 1305             


Val Gly  Glu Ala Gly Leu Pro  Trp Asn Phe Gly Pro  Leu Ser Lys 
    1310                 1315                 1320             


Pro Arg  Arg Glu Leu Arg Arg  Ala Ser Pro Gly Met  Ile Asp Val 
    1325                 1330                 1335             


Arg Lys  Asn Pro Leu 
    1340             


<210>  2
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  2

Asp Ser Gly Ile Glu Ser Ala Ser Val Glu Asp Gln Ala Ala Gln Gly 
1               5                   10                  15      


Ala Gly Gly Arg Lys Glu Asp Glu Gly Ala Gln Gln Leu Leu Thr Leu 
            20                  25                  30          


Gln Asn Gln Val Ala Arg Leu Glu Glu Glu Asn Arg Asp Phe Leu Ala 
        35                  40                  45              


Ala Leu Glu Asp Ala Met Glu Gln Tyr Lys Leu Gln Ser Asp Arg Leu 
    50                  55                  60                  


Arg Glu Gln Gln Glu Glu Met Val Glu Leu Arg Leu Arg Leu Glu Leu 
65                  70                  75                  80  


Val Arg Pro Gly Trp Gly Gly Pro Arg Leu Leu Asn Gly Leu Pro Pro 
                85                  90                  95      


Gly Ser Phe Val Pro Arg Pro His Thr Ala Pro Leu Gly Gly Ala His 
            100                 105                 110         


Ala His Val Leu Gly Met Val Pro Pro Ala Cys Leu Pro Gly Asp Glu 
        115                 120                 125             


Val Gly Ser Glu Gln Arg Gly Glu Gln Val Thr Asn 
    130                 135                 140 


<210>  3
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  3

Lys Glu Asp Glu Gly Ala Gln Gln Leu Leu Thr Leu Gln Asn Gln Val 
1               5                   10                  15      


Ala Arg Leu Glu Glu Glu Asn Arg Asp Phe Leu Ala Ala Leu Glu Asp 
            20                  25                  30          


Ala Met Glu Gln Tyr Lys Leu Gln Ser Asp Arg Leu Arg Glu Gln Gln 
        35                  40                  45              


Glu Glu Met Val Glu Leu Arg Leu Arg Leu Glu Leu Val Arg Pro 
    50                  55                  60              


