                         SEQUENCE LISTING

<110>  Fate Therapeutics, Inc.
 
<120>  ENGINEERED iPSC AND ARMED IMMUNE EFFECTOR CELLS

<130>  184143-629601

<160>  59    

<170>  PatentIn version 3.5

<210>  1
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  a construct comprising constant region of TCR-beta (TRBC)

<400>  1

Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
1               5                   10                  15      


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
            20                  25                  30          


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val 
        35                  40                  45              


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
    50                  55                  60                  


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
65                  70                  75                  80  


Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val 
                85                  90                  95      


Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln 
            100                 105                 110         


Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly 
        115                 120                 125             


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135                 140 


<210>  2
<211>  176
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  a construct comprising constant region of TCR-beta(TRBC1)

<400>  2

Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser 
1               5                   10                  15      


Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala 
            20                  25                  30          


Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
        35                  40                  45              


Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu 
    50                  55                  60                  


Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg 
65                  70                  75                  80  


Asn His Phe Arg Cys Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Gln 
                85                  90                  95      


Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg 
            100                 105                 110         


Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala 
        115                 120                 125             


Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala 
    130                 135                 140                 


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
145                 150                 155                 160 


Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe 
                165                 170                 175     


<210>  3
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRBC2

<400>  3

Asp Leu Lys Asn Val Phe Pro Pro Lys Val Ala Val Phe Glu Pro Ser 
1               5                   10                  15      


Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala 
            20                  25                  30          


Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
        35                  40                  45              


Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu 
    50                  55                  60                  


Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg 
65                  70                  75                  80  


Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln 
                85                  90                  95      


Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg 
            100                 105                 110         


Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala 
        115                 120                 125             


Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala 
    130                 135                 140                 


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
145                 150                 155                 160 


Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Ser 
                165                 170                 175     


Arg Gly 
        


<210>  4
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary signal peptide for the construct comprising TCR-beta 
       constant region (tgTRBC) - CD8asp

<400>  4

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala 
        


<210>  5
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary signal peptide for the construct comprising TCR-beta 
       constant region (tgTRBC) - IgKsp

<400>  5

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg 
            20      


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker peptide for the construct comprising TCR-beta 
       constant region (tgTRBC) - FLAG

<400>  6

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  7
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  340 a.a. CD64 domain-based construction

<400>  7

Met Trp Phe Leu Thr Thr Leu Leu Leu Trp Val Pro Val Asp Gly Gln 
1               5                   10                  15      


Val Asp Thr Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp Val Ser 
            20                  25                  30          


Val Phe Gln Glu Glu Thr Val Thr Leu His Cys Glu Val Leu His Leu 
        35                  40                  45              


Pro Gly Ser Ser Ser Thr Gln Trp Phe Leu Asn Gly Thr Ala Thr Gln 
    50                  55                  60                  


Thr Ser Thr Pro Ser Tyr Arg Ile Thr Ser Ala Ser Val Asn Asp Ser 
65                  70                  75                  80  


Gly Glu Tyr Arg Cys Gln Arg Gly Leu Ser Gly Arg Ser Asp Pro Ile 
                85                  90                  95      


Gln Leu Glu Ile His Arg Gly Trp Leu Leu Leu Gln Val Ser Ser Arg 
            100                 105                 110         


Val Phe Thr Glu Gly Glu Pro Leu Ala Leu Arg Cys His Ala Trp Lys 
        115                 120                 125             


Asp Lys Leu Val Tyr Asn Val Leu Tyr Tyr Arg Asn Gly Lys Ala Phe 
    130                 135                 140                 


Lys Phe Phe His Trp Asn Ser Asn Leu Thr Ile Leu Lys Thr Asn Ile 
145                 150                 155                 160 


Ser His Asn Gly Thr Tyr His Cys Ser Gly Met Gly Lys His Arg Tyr 
                165                 170                 175     


Thr Ser Ala Gly Ile Ser Val Thr Val Lys Glu Leu Phe Pro Ala Pro 
            180                 185                 190         


Val Leu Asn Ala Ser Val Thr Ser Pro Leu Leu Glu Gly Asn Leu Val 
        195                 200                 205             


Thr Leu Ser Cys Glu Thr Lys Leu Leu Leu Gln Arg Pro Gly Leu Gln 
    210                 215                 220                 


Leu Tyr Phe Ser Phe Tyr Met Gly Ser Lys Thr Leu Arg Gly Arg Asn 
225                 230                 235                 240 


Thr Ser Ser Glu Tyr Gln Ile Leu Thr Ala Arg Arg Glu Asp Ser Gly 
                245                 250                 255     


Leu Tyr Trp Cys Glu Ala Ala Thr Glu Asp Gly Asn Val Leu Lys Arg 
            260                 265                 270         


Ser Pro Glu Leu Glu Leu Gln Val Leu Gly Leu Gln Leu Pro Thr Pro 
        275                 280                 285             


Val Trp Phe His Tyr Gln Val Ser Phe Cys Leu Val Met Val Leu Leu 
    290                 295                 300                 


Phe Ala Val Asp Thr Gly Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg 
305                 310                 315                 320 


Ser Ser Thr Arg Asp Trp Lys Asp His Lys Phe Lys Trp Arg Lys Asp 
                325                 330                 335     


Pro Gln Asp Lys 
            340 


<210>  8
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  336 a.a. CD64 exon-based construction

<400>  8

Met Trp Phe Leu Thr Thr Leu Leu Leu Trp Val Pro Val Asp Gly Gln 
1               5                   10                  15      


Val Asp Thr Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp Val Ser 
            20                  25                  30          


Val Phe Gln Glu Glu Thr Val Thr Leu His Cys Glu Val Leu His Leu 
        35                  40                  45              


Pro Gly Ser Ser Ser Thr Gln Trp Phe Leu Asn Gly Thr Ala Thr Gln 
    50                  55                  60                  


Thr Ser Thr Pro Ser Tyr Arg Ile Thr Ser Ala Ser Val Asn Asp Ser 
65                  70                  75                  80  


Gly Glu Tyr Arg Cys Gln Arg Gly Leu Ser Gly Arg Ser Asp Pro Ile 
                85                  90                  95      


Gln Leu Glu Ile His Arg Gly Trp Leu Leu Leu Gln Val Ser Ser Arg 
            100                 105                 110         


Val Phe Thr Glu Gly Glu Pro Leu Ala Leu Arg Cys His Ala Trp Lys 
        115                 120                 125             


Asp Lys Leu Val Tyr Asn Val Leu Tyr Tyr Arg Asn Gly Lys Ala Phe 
    130                 135                 140                 


Lys Phe Phe His Trp Asn Ser Asn Leu Thr Ile Leu Lys Thr Asn Ile 
145                 150                 155                 160 


Ser His Asn Gly Thr Tyr His Cys Ser Gly Met Gly Lys His Arg Tyr 
                165                 170                 175     


Thr Ser Ala Gly Ile Ser Val Thr Val Lys Glu Leu Phe Pro Ala Pro 
            180                 185                 190         


Val Leu Asn Ala Ser Val Thr Ser Pro Leu Leu Glu Gly Asn Leu Val 
        195                 200                 205             


Thr Leu Ser Cys Glu Thr Lys Leu Leu Leu Gln Arg Pro Gly Leu Gln 
    210                 215                 220                 


Leu Tyr Phe Ser Phe Tyr Met Gly Ser Lys Thr Leu Arg Gly Arg Asn 
225                 230                 235                 240 


Thr Ser Ser Glu Tyr Gln Ile Leu Thr Ala Arg Arg Glu Asp Ser Gly 
                245                 250                 255     


Leu Tyr Trp Cys Glu Ala Ala Thr Glu Asp Gly Asn Val Leu Lys Arg 
            260                 265                 270         


Ser Pro Glu Leu Glu Leu Gln Val Leu Gly Leu Phe Phe Pro Pro Gly 
        275                 280                 285             


Tyr Gln Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp 
    290                 295                 300                 


Thr Gly Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg 
305                 310                 315                 320 


Asp Trp Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
                325                 330                 335     


<210>  9
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  335 a.a. CD64 exon-based construction

<400>  9

Met Trp Phe Leu Thr Thr Leu Leu Leu Trp Val Pro Val Asp Gly Gln 
1               5                   10                  15      


Val Asp Thr Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp Val Ser 
            20                  25                  30          


Val Phe Gln Glu Glu Thr Val Thr Leu His Cys Glu Val Leu His Leu 
        35                  40                  45              


Pro Gly Ser Ser Ser Thr Gln Trp Phe Leu Asn Gly Thr Ala Thr Gln 
    50                  55                  60                  


Thr Ser Thr Pro Ser Tyr Arg Ile Thr Ser Ala Ser Val Asn Asp Ser 
65                  70                  75                  80  


Gly Glu Tyr Arg Cys Gln Arg Gly Leu Ser Gly Arg Ser Asp Pro Ile 
                85                  90                  95      


Gln Leu Glu Ile His Arg Gly Trp Leu Leu Leu Gln Val Ser Ser Arg 
            100                 105                 110         


Val Phe Thr Glu Gly Glu Pro Leu Ala Leu Arg Cys His Ala Trp Lys 
        115                 120                 125             


Asp Lys Leu Val Tyr Asn Val Leu Tyr Tyr Arg Asn Gly Lys Ala Phe 
    130                 135                 140                 


Lys Phe Phe His Trp Asn Ser Asn Leu Thr Ile Leu Lys Thr Asn Ile 
145                 150                 155                 160 


Ser His Asn Gly Thr Tyr His Cys Ser Gly Met Gly Lys His Arg Tyr 
                165                 170                 175     


Thr Ser Ala Gly Ile Ser Val Thr Val Lys Glu Leu Phe Pro Ala Pro 
            180                 185                 190         


Val Leu Asn Ala Ser Val Thr Ser Pro Leu Leu Glu Gly Asn Leu Val 
        195                 200                 205             


Thr Leu Ser Cys Glu Thr Lys Leu Leu Leu Gln Arg Pro Gly Leu Gln 
    210                 215                 220                 


Leu Tyr Phe Ser Phe Tyr Met Gly Ser Lys Thr Leu Arg Gly Arg Asn 
225                 230                 235                 240 


Thr Ser Ser Glu Tyr Gln Ile Leu Thr Ala Arg Arg Glu Asp Ser Gly 
                245                 250                 255     


Leu Tyr Trp Cys Glu Ala Ala Thr Glu Asp Gly Asn Val Leu Lys Arg 
            260                 265                 270         


Ser Pro Glu Leu Glu Leu Gln Val Leu Gly Phe Phe Pro Pro Gly Tyr 
        275                 280                 285             


Gln Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr 
    290                 295                 300                 


Gly Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp 
305                 310                 315                 320 


Trp Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
                325                 330                 335 


<210>  10
<211>  1032
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  exemplifying sequence encoding 340 a.a. CD64 domain-based 
       construction

<400>  10
cttggagaca acatgtggtt cttgacaact ctgctccttt gggttccagt tgatgggcaa       60

gtggacacca caaaggcagt gatcactttg cagcctccat gggtcagcgt gttccaagag      120

gaaaccgtaa ccttgcattg tgaggtgctc catctgcctg ggagcagctc tacacagtgg      180

tttctcaatg gcacagccac tcagacctcg acccccagct acagaatcac ctctgccagt      240

gtcaatgaca gtggtgaata caggtgccag agaggtctct cagggcgaag tgaccccata      300

cagctggaaa tccacagagg ctggctacta ctgcaggtct ccagcagagt cttcacggaa      360

ggagaacctc tggccttgag gtgtcatgcg tggaaggata agctggtgta caatgtgctt      420

tactatcgaa atggcaaagc ctttaagttt ttccactgga attctaacct caccattctg      480

aaaaccaaca taagtcacaa tggcacctac cattgctcag gcatgggaaa gcatcgctac      540

acatcagcag gaatatctgt cactgtgaaa gagctatttc cagctccagt gctgaatgca      600

tctgtgacat ccccactcct ggaggggaat ctggtcaccc tgagctgtga aacaaagttg      660

ctcttgcaga ggcctggttt gcagctttac ttctccttct acatgggcag caagaccctg      720

cgaggcagga acacatcctc tgaataccaa atactaactg ctagaagaga agactctggg      780

ttatactggt gcgaggctgc cacagaggat ggaaatgtcc ttaagcgcag ccctgagttg      840

gagcttcaag tgcttggcct ccagttacca actcctgtct ggtttcatta ccaagtctct      900

ttctgcttgg tgatggtact cctttttgca gtggacacag gactatattt ctctgtgaag      960

acaaacattc gaagctcaac aagagactgg aaggaccata aatttaaatg gagaaaggac     1020

cctcaagaca aa                                                         1032


<210>  11
<211>  1020
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  exemplifying sequence encoding 336 a.a. CD64 exon-based 
       construction

<400>  11
cttggagaca acatgtggtt cttgacaact ctgctccttt gggttccagt tgatgggcaa       60

gtggacacca caaaggcagt gatcactttg cagcctccat gggtcagcgt gttccaagag      120

gaaaccgtaa ccttgcattg tgaggtgctc catctgcctg ggagcagctc tacacagtgg      180

tttctcaatg gcacagccac tcagacctcg acccccagct acagaatcac ctctgccagt      240

gtcaatgaca gtggtgaata caggtgccag agaggtctct cagggcgaag tgaccccata      300

cagctggaaa tccacagagg ctggctacta ctgcaggtct ccagcagagt cttcacggaa      360

ggagaacctc tggccttgag gtgtcatgcg tggaaggata agctggtgta caatgtgctt      420

tactatcgaa atggcaaagc ctttaagttt ttccactgga attctaacct caccattctg      480

aaaaccaaca taagtcacaa tggcacctac cattgctcag gcatgggaaa gcatcgctac      540

acatcagcag gaatatctgt cactgtgaaa gagctatttc cagctccagt gctgaatgca      600

tctgtgacat ccccactcct ggaggggaat ctggtcaccc tgagctgtga aacaaagttg      660

ctcttgcaga ggcctggttt gcagctttac ttctccttct acatgggcag caagaccctg      720

cgaggcagga acacatcctc tgaataccaa atactaactg ctagaagaga agactctggg      780

ttatactggt gcgaggctgc cacagaggat ggaaatgtcc ttaagcgcag ccctgagttg      840

gagcttcaag tgcttggttt gttctttcca cctgggtacc aagtctcttt ctgcttggtg      900

atggtactcc tttttgcagt ggacacagga ctatatttct ctgtgaagac aaacattcga      960

agctcaacaa gagactggaa ggaccataaa tttaaatgga gaaaggaccc tcaagacaaa     1020


<210>  12
<211>  1005
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  exemplifying sequence encoding 335 a.a. CD64 exon-based 
       construction

<400>  12
atgtggttct tgacaactct gctcctttgg gttccagttg atgggcaagt ggacaccaca       60

aaggcagtga tcactttgca gcctccatgg gtcagcgtgt tccaagagga aaccgtaacc      120

ttgcactgtg aggtgctcca tctgcctggg agcagctcta cacagtggtt tctcaatggc      180

acagccactc agacctcgac ccccagctac agaatcacct ctgccagtgt caatgacagt      240

ggtgaataca ggtgccagag aggtctctca gggcgaagtg accccataca gctggaaatc      300

cacagaggct ggctactact gcaggtctcc agcagagtct tcacggaagg agaacctctg      360

gccttgaggt gtcatgcgtg gaaggataag ctggtgtaca atgtgcttta ctatcgaaat      420

ggcaaagcct ttaagttttt ccactggaac tctaacctca ccattctgaa aaccaacata      480

agtcacaatg gcacctacca ttgctcaggc atgggaaagc atcgctacac atcagcagga      540

atatctgtca ctgtgaaaga gctatttcca gctccagtgc tgaatgcatc tgtgacatcc      600

ccactcctgg aggggaatct ggtcaccctg agctgtgaaa caaagttgct cttgcagagg      660

cctggtttgc agctttactt ctccttctac atgggcagca agaccctgcg aggcaggaac      720

acatcctctg aataccaaat actaactgct agaagagaag actctgggtt atactggtgc      780

gaggctgcca cagaggatgg aaatgtcctt aagcgcagcc ctgagttgga gcttcaagtg      840

cttggcttct ttccacctgg gtaccaagtc tctttctgct tggtgatggt actccttttt      900

gcagtggaca caggactata tttctctgtg aagacaaaca ttcgaagctc aacaagagac      960

tggaaggacc ataaatttaa atggagaaag gaccctcaag acaaa                     1005


<210>  13
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  153 a.a. CD28 co-stim + CD3-zeta-ITAM

<400>  13

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
        35                  40                  45              


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
    50                  55                  60                  


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
65                  70                  75                  80  


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
                85                  90                  95      


Glu Gly Leu Phe Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Phe 
            100                 105                 110         


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
        115                 120                 125             


Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Phe Asp Ala 
    130                 135                 140                 


Leu His Met Gln Ala Leu Pro Pro Arg 
145                 150             


<210>  14
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  219 a.a. CD28 hinge + CD28 TM + CD28 co-stim + CD3-zeta-ITAM

<400>  14

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        35                  40                  45              


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    50                  55                  60                  


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
65                  70                  75                  80  


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
                85                  90                  95      


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser 
            100                 105                 110         


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
        115                 120                 125             


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
    130                 135                 140                 


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
145                 150                 155                 160 


Pro Gln Glu Gly Leu Phe Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
                165                 170                 175     


Ala Phe Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
            180                 185                 190         


His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Phe 
        195                 200                 205             


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    210                 215                 


<210>  15
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  263 a.a NKG2D TM + 2B4 + CD3-zeta

<400>  15

Ser Asn Leu Phe Val Ala Ser Trp Ile Ala Val Met Ile Ile Phe Arg 
1               5                   10                  15      


Ile Gly Met Ala Val Ala Ile Phe Cys Cys Phe Phe Phe Pro Ser Trp 
            20                  25                  30          


Arg Arg Lys Arg Lys Glu Lys Gln Ser Glu Thr Ser Pro Lys Glu Phe 
        35                  40                  45              


Leu Thr Ile Tyr Glu Asp Val Lys Asp Leu Lys Thr Arg Arg Asn His 
    50                  55                  60                  


Glu Gln Glu Gln Thr Phe Pro Gly Gly Gly Ser Thr Ile Tyr Ser Met 
65                  70                  75                  80  


Ile Gln Ser Gln Ser Ser Ala Pro Thr Ser Gln Glu Pro Ala Tyr Thr 
                85                  90                  95      


Leu Tyr Ser Leu Ile Gln Pro Ser Arg Lys Ser Gly Ser Arg Lys Arg 
            100                 105                 110         


Asn His Ser Pro Ser Phe Asn Ser Thr Ile Tyr Glu Val Ile Gly Lys 
        115                 120                 125             


Ser Gln Pro Lys Ala Gln Asn Pro Ala Arg Leu Ser Arg Lys Glu Leu 
    130                 135                 140                 


Glu Asn Phe Asp Val Tyr Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
145                 150                 155                 160 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
                165                 170                 175     


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
            180                 185                 190         


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
        195                 200                 205             


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
    210                 215                 220                 


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
225                 230                 235                 240 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
                245                 250                 255     


Met Gln Ala Leu Pro Pro Arg 
            260             


<210>  16
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  308 a.a CD8 hinge + NKG2D TM + 2B4 + CD3-zeta

<400>  16

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ser Asn Leu 
        35                  40                  45              


Phe Val Ala Ser Trp Ile Ala Val Met Ile Ile Phe Arg Ile Gly Met 
    50                  55                  60                  


Ala Val Ala Ile Phe Cys Cys Phe Phe Phe Pro Ser Trp Arg Arg Lys 
65                  70                  75                  80  


Arg Lys Glu Lys Gln Ser Glu Thr Ser Pro Lys Glu Phe Leu Thr Ile 
                85                  90                  95      


Tyr Glu Asp Val Lys Asp Leu Lys Thr Arg Arg Asn His Glu Gln Glu 
            100                 105                 110         


Gln Thr Phe Pro Gly Gly Gly Ser Thr Ile Tyr Ser Met Ile Gln Ser 
        115                 120                 125             


Gln Ser Ser Ala Pro Thr Ser Gln Glu Pro Ala Tyr Thr Leu Tyr Ser 
    130                 135                 140                 


Leu Ile Gln Pro Ser Arg Lys Ser Gly Ser Arg Lys Arg Asn His Ser 
145                 150                 155                 160 


Pro Ser Phe Asn Ser Thr Ile Tyr Glu Val Ile Gly Lys Ser Gln Pro 
                165                 170                 175     


Lys Ala Gln Asn Pro Ala Arg Leu Ser Arg Lys Glu Leu Glu Asn Phe 
            180                 185                 190         


Asp Val Tyr Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
        195                 200                 205             


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
    210                 215                 220                 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
225                 230                 235                 240 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
                245                 250                 255     


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
            260                 265                 270         


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
        275                 280                 285             


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
    290                 295                 300                 


Leu Pro Pro Arg 
305             


<210>  17
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  construct mimicking trans-presentation of IL15 (design 3)

<400>  17

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu 
            20                  25                  30          


Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
        35                  40                  45              


Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
    50                  55                  60                  


Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
65                  70                  75                  80  


Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
                85                  90                  95      


His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
            100                 105                 110         


Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
        115                 120                 125             


Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
    130                 135                 140                 


Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu 
                165                 170                 175     


Gln Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp 
            180                 185                 190         


Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser 
        195                 200                 205             


Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu 
    210                 215                 220                 


Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
225                 230                 235                 240 


Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr 
                245                 250                 255     


Val Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser 
            260                 265                 270         


Gly Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala 
        275                 280                 285             


Thr Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser 
    290                 295                 300                 


Pro Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly 
305                 310                 315                 320 


Thr Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala 
                325                 330                 335     


Ser His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr 
            340                 345                 350         


Val Ala Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val 
        355                 360                 365             


Ser Leu Leu Ala Cys Tyr Leu Lys Ser Arg Gln 
    370                 375                 


<210>  18
<211>  1140
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  an exemplary nucleic acid sequence encoding construct mimicking 
       trans-presentation of IL15 (design 3)

<400>  18
atggactgga cctggattct gttcctggtc gcggctgcaa cgcgagtcca tagcggtatc       60

catgttttta ttcttgggtg tttttctgct gggctgccta agaccgaggc caactgggta      120

aatgtcatca gtgacctcaa gaaaatagaa gaccttatac aaagcatgca cattgatgct      180

actctctaca ctgagtcaga tgtacatccc tcatgcaaag tgacggccat gaaatgtttc      240

ctcctcgaac ttcaagtcat atctctggaa agtggcgacg cgtccatcca cgacacggtc      300

gaaaacctga taatactcgc taataatagt ctctcttcaa atggtaacgt aaccgagtca      360

ggttgcaaag agtgcgaaga gttggaagaa aaaaacataa aggagttcct gcaaagtttc      420

gtgcacattg tgcagatgtt cattaatacc tctagcggcg gaggatcagg tggcggtgga      480

agcggaggtg gaggctccgg tggaggaggt agtggcggag gttctcttca aataacttgt      540

cctccaccga tgtccgtaga acatgcggat atttgggtaa aatcctatag cttgtacagc      600

cgagagcggt atatctgcaa cagcggcttc aagcggaagg ccggcacaag cagcctgacc      660

gagtgcgtgc tgaacaaggc caccaacgtg gcccactgga ccacccctag cctgaagtgc      720

atcagagatc ccgccctggt gcatcagcgg cctgcccctc caagcacagt gacaacagct      780

ggcgtgaccc cccagcctga gagcctgagc ccttctggaa aagagcctgc cgccagcagc      840

cccagcagca acaatactgc cgccaccaca gccgccatcg tgcctggatc tcagctgatg      900

cccagcaaga gccctagcac cggcaccacc gagatcagca gccacgagtc tagccacggc      960

accccatctc agaccaccgc caagaactgg gagctgacag ccagcgcctc tcaccagcct     1020

ccaggcgtgt accctcaggg ccacagcgat accacagtgg ccatcagcac ctccaccgtg     1080

ctgctgtgtg gactgagcgc cgtgtcactg ctggcctgct acctgaagtc cagacagtga     1140


<210>  19
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fused IL15/mb-Sushi construct (design 4)

<400>  19

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu 
            20                  25                  30          


Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
        35                  40                  45              


Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
    50                  55                  60                  


Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
65                  70                  75                  80  


Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
                85                  90                  95      


His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
            100                 105                 110         


Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
        115                 120                 125             


Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
    130                 135                 140                 


Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu 
                165                 170                 175     


Gln Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp 
            180                 185                 190         


Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser 
        195                 200                 205             


Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu 
    210                 215                 220                 


Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
225                 230                 235                 240 


Ile Arg 
        


<210>  20
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  an exemplary nucleic acid sequence encoding fused IL15/mb-Sushi 
       construct (design 4)

<400>  20
atggactgga cctggattct gttcctggtc gcggctgcaa cgcgagtcca tagcggtatc       60

catgttttta ttcttgggtg tttttctgct gggctgccta agaccgaggc caactgggta      120

aatgtcatca gtgacctcaa gaaaatagaa gaccttatac aaagcatgca cattgatgct      180

actctctaca ctgagtcaga tgtacatccc tcatgcaaag tgacggccat gaaatgtttc      240

ctcctcgaac ttcaagtcat atctctggaa agtggcgacg cgtccatcca cgacacggtc      300

gaaaacctga taatactcgc taataatagt ctctcttcaa atggtaacgt aaccgagtca      360

ggttgcaaag agtgcgaaga gttggaagaa aaaaacataa aggagttcct gcaaagtttc      420

gtgcacattg tgcagatgtt cattaatacc tctagcggcg gaggatcagg tggcggtgga      480

agcggaggtg gaggctccgg tggaggaggt agtggcggag gttctcttca aataacttgt      540

cctccaccga tgtccgtaga acatgcggat atttgggtaa aatcctatag cttgtacagc      600

cgagagcggt atatctgcaa cagcggcttc aagcggaagg ccggcacaag cagcctgacc      660

gagtgcgtgc tgaacaaggc caccaacgtg gcccactgga ccacccctag cctgaagtgc      720

atcaga                                                                 726


<210>  21
<211>  375
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protein construct further modified from SEQ ID NO. 17

<400>  21

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu 
            20                  25                  30          


Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
        35                  40                  45              


Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
    50                  55                  60                  


Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
65                  70                  75                  80  


Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
                85                  90                  95      


His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
            100                 105                 110         


Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
        115                 120                 125             


Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
    130                 135                 140                 


Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu 
                165                 170                 175     


Gln Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp 
            180                 185                 190         


Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser 
        195                 200                 205             


Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu 
    210                 215                 220                 


Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
225                 230                 235                 240 


Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr 
                245                 250                 255     


Val Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser 
            260                 265                 270         


Gly Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala 
        275                 280                 285             


Thr Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser 
    290                 295                 300                 


Pro Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly 
305                 310                 315                 320 


Thr Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala 
                325                 330                 335     


Ser His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr 
            340                 345                 350         


Val Ala Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val 
        355                 360                 365             


Ser Leu Leu Ala Cys Tyr Leu 
    370                 375 


<210>  22
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  non-limiting exemplary signal peptide for the construct 
       comprising tgpTCR-alpha

<400>  22

Met Ala Gly Thr Trp Leu Leu Leu Leu Leu Ala Leu Gly Cys Pro Ala 
1               5                   10                  15      


Leu Pro Thr Gly Val Gly Gly 
            20              


<210>  23
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary sequence of a construct comprising tgpTCR-alpha 
       (tgpTCR-alpha with TM)

<400>  23

Thr Pro Phe Pro Ser Leu Ala Pro Pro Ile Met Leu Leu Val Asp Gly 
1               5                   10                  15      


Lys Gln Gln Met Val Val Val Cys Leu Val Leu Asp Val Ala Pro Pro 
            20                  25                  30          


Gly Leu Asp Ser Pro Ile Trp Phe Ser Ala Gly Asn Gly Ser Ala Leu 
        35                  40                  45              


Asp Ala Phe Thr Tyr Gly Pro Ser Pro Ala Thr Asp Gly Thr Trp Thr 
    50                  55                  60                  


Asn Leu Ala His Leu Ser Leu Pro Ser Glu Glu Leu Ala Ser Trp Glu 
65                  70                  75                  80  


Pro Leu Val Cys His Thr Gly Pro Gly Ala Glu Gly His Ser Arg Ser 
                85                  90                  95      


Thr Gln Pro Met His Leu Ser Gly Glu Ala Ser Thr Ala Arg Thr Cys 
            100                 105                 110         


Pro Gln Glu Pro Leu Arg Gly Gly Cys Gly Leu Leu Arg Ala Pro Glu 
        115                 120                 125             


Arg Phe Leu Leu Ala Gly Thr Pro Gly Gly Ala Leu Trp Leu Gly Val 
    130                 135                 140                 


Leu Arg Leu Leu Leu Phe Lys Leu Leu Leu Phe Asp Leu Leu Leu Thr 
145                 150                 155                 160 


Cys Ser Cys Leu Cys Asp Pro Ala Gly Pro Leu Pro Ser Pro Ala Thr 
                165                 170                 175     


Thr Thr Arg Leu Arg Ala Leu Gly Ser His Arg Leu His Pro Ala Thr 
            180                 185                 190         


Glu Thr Gly Gly Arg Glu Ala Thr Ser Ser Pro Arg Pro Gln Pro Arg 
        195                 200                 205             


Asp Arg Arg Trp Gly Asp Thr Pro Pro Gly Arg Lys Pro Gly Ser Pro 
    210                 215                 220                 


Val Trp Gly Glu Gly Ser Tyr Leu Ser Ser Tyr Pro Thr Cys Pro Ala 
225                 230                 235                 240 


Gln Ala Trp Cys Ser Arg Ser Ala Leu Arg Ala Pro Ser Ser Ser Leu 
                245                 250                 255     


Gly Ala Phe Phe Ala Gly Asp Leu Pro Pro Pro Leu Gln Ala Gly Ala 
            260                 265                 270         


Ala 
    


<210>  24
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  partial length of a construct comprising tgpTCR-alpha (Truncated 
       tgpTCR-alpha with TM)

<400>  24

Thr Pro Phe Pro Ser Leu Ala Pro Pro Ile Met Leu Leu Val Asp Gly 
1               5                   10                  15      


Lys Gln Gln Met Val Val Val Cys Leu Val Leu Asp Val Ala Pro Pro 
            20                  25                  30          


Gly Leu Asp Ser Pro Ile Trp Phe Ser Ala Gly Asn Gly Ser Ala Leu 
        35                  40                  45              


Asp Ala Phe Thr Tyr Gly Pro Ser Pro Ala Thr Asp Gly Thr Trp Thr 
    50                  55                  60                  


Asn Leu Ala His Leu Ser Leu Pro Ser Glu Glu Leu Ala Ser Trp Glu 
65                  70                  75                  80  


Pro Leu Val Cys His Thr Gly Pro Gly Ala Glu Gly His Ser Arg Ser 
                85                  90                  95      


Thr Gln Pro Met His Leu Ser Gly Glu Ala Ser Thr Ala Arg Thr Cys 
            100                 105                 110         


Pro Gln Glu Pro Leu Arg Gly Gly Cys Gly Leu Leu Arg Ala Pro Glu 
        115                 120                 125             


Arg Phe Leu Leu Ala Gly Thr Pro Gly Gly Ala Leu Trp Leu Gly Val 
    130                 135                 140                 


Leu Arg Leu Leu Leu Phe Lys Leu Leu Leu Phe Asp Leu Leu Leu Thr 
145                 150                 155                 160 


Cys Ser Cys Leu Cys Asp Pro Ala Gly Pro Leu Pro Ser Pro Ala Thr 
                165                 170                 175     


Thr Thr Arg Leu Arg Ala Leu Gly Ser His Arg Leu His Pro Ala Thr 
            180                 185                 190         


Glu Thr Gly Gly Arg Glu Ala Thr Ser Ser Pro Arg Pro Gln Pro Arg 
        195                 200                 205             


Asp Arg Arg Trp Gly Asp Thr Pro Pro Gly Arg Lys Pro Gly Ser Pro 
    210                 215                 220                 


Val 
225 


<210>  25
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary sequence of a construct comprising a full or partial 
       length of CD3-epsilon ectodomain

<400>  25

Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val 
1               5                   10                  15      


Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly 
            20                  25                  30          


Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu 
        35                  40                  45              


Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu 
    50                  55                  60                  


Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly 
65                  70                  75                  80  


Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val 
                85                  90                  95      


Cys Glu Asn Cys Met Glu Met Asp 
            100                 


<210>  26
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary sequence of a construct comprising a full or partial 
       length of CD3-delta ectodomain

<400>  26

Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg Val Phe Val Asn Cys 
1               5                   10                  15      


Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val Gly Thr Leu Leu Ser 
            20                  25                  30          


Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile Leu Asp Pro Arg Gly 
        35                  40                  45              


Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys Asp Lys Glu Ser Thr 
    50                  55                  60                  


Val Gln Val His Tyr Arg Met Cys Gln Ser Cys Val Glu Leu Asp Pro 
65                  70                  75                  80  


Ala Thr Val Ala 
                


<210>  27
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary sequence of a construct comprising a full or partial 
       length of CD3-gamma ectodomain

<400>  27

Gln Ser Ile Lys Gly Asn His Leu Val Lys Val Tyr Asp Tyr Gln Glu 
1               5                   10                  15      


Asp Gly Ser Val Leu Leu Thr Cys Asp Ala Glu Ala Lys Asn Ile Thr 
            20                  25                  30          


Trp Phe Lys Asp Gly Lys Met Ile Gly Phe Leu Thr Glu Asp Lys Lys 
        35                  40                  45              


Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp Pro Arg Gly Met Tyr Gln 
    50                  55                  60                  


Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro Leu Gln Val Tyr Tyr Arg 
65                  70                  75                  80  


Met Cys Gln Asn Cys Ile Glu Leu Asn Ala Ala Thr Ile Ser 
                85                  90                  


<210>  28
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide for a construct comprising a full or partial 
       length of CD3-epsilon ectodomain

<400>  28

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln 
            20          


<210>  29
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide for a construct comprising a full or partial 
       length of CD3-delta ectodomain

<400>  29

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro 
            20      


<210>  30
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide for a construct comprising a full or partial 
       length of CD3-gamma ectodomain

<400>  30

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala 
            20          


<210>  31
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary sequence comprising tgCD3(epsilon-delta)-TRAC fusion 
       protein

<400>  31

Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val 
1               5                   10                  15      


Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly 
            20                  25                  30          


Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu 
        35                  40                  45              


Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu 
    50                  55                  60                  


Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly 
65                  70                  75                  80  


Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val 
                85                  90                  95      


Gly Ser Ala Asp Asp Ala Lys Lys Asp Ala Ala Lys Lys Asp Asp Ala 
            100                 105                 110         


Lys Lys Asp Asp Ala Lys Lys Asp Gly Ser Phe Lys Ile Pro Ile Glu 
        115                 120                 125             


Glu Leu Glu Asp Arg Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp 
    130                 135                 140                 


Val Glu Gly Thr Val Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp 
145                 150                 155                 160 


Leu Gly Lys Arg Ile Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly 
                165                 170                 175     


Thr Asp Ile Tyr Lys Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg 
            180                 185                 190         


Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        195                 200                 205             


Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
    210                 215                 220                 


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
225                 230                 235                 240 


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val 
                245                 250                 255     


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
            260                 265                 270         


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
        275                 280                 285             


Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val 
    290                 295                 300                 


Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln 
305                 310                 315                 320 


Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly 
                325                 330                 335     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            340                 345             


<210>  32
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary sequence comprising tgCD3(epsilon-delta)-TRAC fusion 
       protein

<400>  32

Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val 
1               5                   10                  15      


Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly 
            20                  25                  30          


Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu 
        35                  40                  45              


Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu 
    50                  55                  60                  


Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly 
65                  70                  75                  80  


Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val 
                85                  90                  95      


Gly Ser Ala Asp Asp Ala Lys Lys Asp Ala Ala Lys Lys Asp Asp Ala 
            100                 105                 110         


Lys Lys Asp Asp Ala Lys Lys Asp Gly Ser Gln Ser Ile Lys Gly Asn 
        115                 120                 125             


His Leu Val Lys Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu 
    130                 135                 140                 


Thr Cys Asp Ala Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys 
145                 150                 155                 160 


Met Ile Gly Phe Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser 
                165                 170                 175     


Asn Ala Lys Asp Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn 
            180                 185                 190         


Lys Ser Lys Pro Leu Gln Val Tyr Tyr Arg Met Gly Gly Gly Gly Ser 
        195                 200                 205             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Leu Asn Lys Val Phe 
    210                 215                 220                 


Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His 
225                 230                 235                 240 


Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp 
                245                 250                 255     


His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly 
            260                 265                 270         


Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp 
        275                 280                 285             


Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp 
    290                 295                 300                 


Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu 
305                 310                 315                 320 


Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln 
                325                 330                 335     


Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser 
            340                 345                 350         


Val Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile 
        355                 360                 365             


Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val 
    370                 375                 380                 


Leu Met Ala Met Val Lys Arg Lys Asp Phe 
385                 390                 


<210>  33
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence to the sequence comprising 
       tgCD3(epsilon-delta)-TRAC fusion protein (G4S linker)

<400>  33

Gly Ser Ala Asp Asp Ala Lys Lys Asp Ala Ala Lys Lys Asp Asp Ala 
1               5                   10                  15      


Lys Lys Asp Asp Ala Lys Lys Asp Gly Ser 
            20                  25      


<210>  34
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence to the sequence comprising 
       tgCD3(epsilon-delta)-TRAC fusion protein (G4S linker)

<400>  34

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  35
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary sequence comprising a full or partial length of 
       CD3-zeta endodomain

<400>  35

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            100                 105                 110         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        115                 120                 125             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    130                 135                 140                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
145                 150                 155                 160 


Pro Pro Arg 
            


<210>  36
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITAM1 sequence

<400>  36

Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
1               5                   10                  15      


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
            20                  25                  


<210>  37
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITAM2 sequence

<400>  37

Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
1               5                   10                  15      


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
            20                  25              


<210>  38
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITAM3 sequence

<400>  38

Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
1               5                   10                  15      


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
            20                  25                  


<210>  39
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary sequence from which any one or two CD3-zeta ITAMs may 
       be removed

<400>  39

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
        35                  40                  45              


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
    50                  55                  60                  


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
65                  70                  75                  80  


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
                85                  90                  95      


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
            100                 105                 110         


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
        115                 120                 125             


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
    130                 135                 140                 


Leu His Met Gln Ala Leu Pro Pro Arg 
145                 150             


<210>  40
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary sequence CD3 chimeric chain with 41BB signaling domain 
       from which any one or two CD3-zeta ITAMs may be removed

<400>  40

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
        35                  40                  45              


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
    50                  55                  60                  


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
65                  70                  75                  80  


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
                85                  90                  95      


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
            100                 105                 110         


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
        115                 120                 125             


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
    130                 135                 140                 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
145                 150                 


<210>  41
<211>  195
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary sequence comprising a full or partial length of 
       28BB-zeta endodomain

<400>  41

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu 
        35                  40                  45              


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
    50                  55                  60                  


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
65                  70                  75                  80  


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
                85                  90                  95      


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
            100                 105                 110         


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
        115                 120                 125             


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
    130                 135                 140                 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
145                 150                 155                 160 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
                165                 170                 175     


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
            180                 185                 190         


Pro Pro Arg 
        195 


<210>  42
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary sequence comprising a full or partial length of 
       28BB-zeta endodomain

<400>  42

Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val 
1               5                   10                  15      


Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly 
            20                  25                  30          


Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu 
        35                  40                  45              


Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu 
    50                  55                  60                  


Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly 
65                  70                  75                  80  


Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val 
                85                  90                  95      


Gly Ser Ala Asp Asp Ala Lys Lys Asp Ala Ala Lys Lys Asp Asp Ala 
            100                 105                 110         


Lys Lys Asp Asp Ala Lys Lys Asp Gly Ser Gln Ser Ile Lys Gly Asn 
        115                 120                 125             


His Leu Val Lys Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu 
    130                 135                 140                 


Thr Cys Asp Ala Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys 
145                 150                 155                 160 


Met Ile Gly Phe Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser 
                165                 170                 175     


Asn Ala Lys Asp Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn 
            180                 185                 190         


Lys Ser Lys Pro Leu Gln Val Tyr Tyr Arg Met Arg Ala Ala Ala Ile 
        195                 200                 205             


Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly 
    210                 215                 220                 


Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe 
225                 230                 235                 240 


Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val 
                245                 250                 255     


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
            260                 265                 270         


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
        275                 280                 285             


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
    290                 295                 300                 


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg 
305                 310                 315                 320 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
                325                 330                 335     


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
            340                 345                 350         


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
        355                 360                 365             


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
    370                 375                 380                 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
385                 390                 395                 400 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
                405                 410                 415     


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            420                 425     


<210>  43
<211>  416
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide comprising construct 
       tgCD3(epsilon-delta)-(28/BB)-zeta

<400>  43

Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val 
1               5                   10                  15      


Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly 
            20                  25                  30          


Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu 
        35                  40                  45              


Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu 
    50                  55                  60                  


Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly 
65                  70                  75                  80  


Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val 
                85                  90                  95      


Gly Ser Ala Asp Asp Ala Lys Lys Asp Ala Ala Lys Lys Asp Asp Ala 
            100                 105                 110         


Lys Lys Asp Asp Ala Lys Lys Asp Gly Ser Phe Lys Ile Pro Ile Glu 
        115                 120                 125             


Glu Leu Glu Asp Arg Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp 
    130                 135                 140                 


Val Glu Gly Thr Val Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp 
145                 150                 155                 160 


Leu Gly Lys Arg Ile Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly 
                165                 170                 175     


Thr Asp Ile Tyr Lys Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg 
            180                 185                 190         


Met Arg Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp 
        195                 200                 205             


Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu 
    210                 215                 220                 


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
225                 230                 235                 240 


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
                245                 250                 255     


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
            260                 265                 270         


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
        275                 280                 285             


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    290                 295                 300                 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
305                 310                 315                 320 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
                325                 330                 335     


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
            340                 345                 350         


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
        355                 360                 365             


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
    370                 375                 380                 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
385                 390                 395                 400 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                405                 410                 415     


<210>  44
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Lys Lys His Leu Thr Thr Phe Leu Val Ile Leu Trp Leu Tyr Phe 
1               5                   10                  15      


Tyr Arg Gly Asn Gly Lys Asn Gln Val Glu Gln Ser Pro Gln Ser Leu 
            20                  25                  30          


Ile Ile Leu Glu Gly Lys Asn Cys Thr Leu Gln Cys Asn Tyr Thr Val 
        35                  40                  45              


Ser Pro Phe Ser Asn Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly 
    50                  55                  60                  


Pro Val Ser Leu Thr Ile Met Thr Phe Ser Glu Asn Thr Lys Ser Asn 
65                  70                  75                  80  


Gly Arg Tyr Thr Ala Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu 
                85                  90                  95      


His Ile Thr Ala Ser Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val 
            100                 105                 110         


Val Ser Asp Arg Gly Ser Thr Leu Gly Arg Leu Tyr Phe Gly Arg Gly 
        115                 120                 125             


Thr Gln Leu Thr Val Trp Pro Asp Ile Gln Asn Pro Asp Pro Ala Val 
    130                 135                 140                 


Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe 
145                 150                 155                 160 


Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp 
                165                 170                 175     


Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe 
            180                 185                 190         


Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys 
        195                 200                 205             


Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro 
    210                 215                 220                 


Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu 
225                 230                 235                 240 


Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg 
                245                 250                 255     


Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg 
            260                 265                 270         


Leu Trp Ser Ser 
        275     


<210>  45
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Thr Ile Arg Leu Leu Cys Tyr Met Gly Phe Tyr Phe Leu Gly Ala 
1               5                   10                  15      


Gly Leu Met Glu Ala Asp Ile Tyr Gln Thr Pro Arg Tyr Leu Val Ile 
            20                  25                  30          


Gly Thr Gly Lys Lys Ile Thr Leu Glu Cys Ser Gln Thr Met Gly His 
        35                  40                  45              


Asp Lys Met Tyr Trp Tyr Gln Gln Asp Pro Gly Met Glu Leu His Leu 
    50                  55                  60                  


Ile His Tyr Ser Tyr Gly Val Asn Ser Thr Glu Lys Gly Asp Leu Ser 
65                  70                  75                  80  


Ser Glu Ser Thr Val Ser Arg Ile Arg Thr Glu His Phe Pro Leu Thr 
                85                  90                  95      


Leu Glu Ser Ala Arg Pro Ser His Thr Ser Gln Tyr Leu Cys Ala Ser 
            100                 105                 110         


Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
        115                 120                 125             


Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
    130                 135                 140                 


Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
145                 150                 155                 160 


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys 
                165                 170                 175     


Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu 
            180                 185                 190         


Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys 
        195                 200                 205             


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp 
    210                 215                 220                 


Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg 
225                 230                 235                 240 


Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser 
                245                 250                 255     


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
            260                 265                 270         


Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp 
        275                 280                 285             


Phe 
    


<210>  46
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  46

Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn 
1               5                   10                  15      


Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu 
            20                  25                  30          


Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys 
        35                  40                  45              


Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr 
    50                  55                  60                  


Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr 
65                  70                  75                  80  


Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile 
                85                  90                  95      


Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly 
            100                 105                 110         


Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe 
        115                 120                 125             


Pro Gly Pro Ser Lys Pro 
    130                 


<210>  47
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  47

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  48
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  48

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr 
            20      


<210>  49
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  49

Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile 
1               5                   10                  15      


Gly Leu Gly Ile Phe Phe 
            20          


<210>  50
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  50

Lys Asn Arg Lys Ala Lys Ala Lys Pro Val Thr Arg Gly Ala Gly Ala 
1               5                   10                  15      


Gly Gly Arg Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro Pro Val Pro 
            20                  25                  30          


Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu Tyr Ser 
        35                  40                  45              


Gly Leu Asn Gln Arg Arg Ile 
    50                  55  


<210>  51
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  51

Lys Asn Arg Lys Ala Lys Ala Lys Pro Val Thr Arg Gly Ala Gly Ala 
1               5                   10                  15      


Gly Gly Arg Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro Pro Val Pro 
            20                  25                  30          


Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu Tyr Ser 
        35                  40                  45              


Gly Leu Asn Gln Ser Arg Ile 
    50                  55  


<210>  52
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  52

Gly His Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu 
1               5                   10                  15      


Leu Arg Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala 
            20                  25                  30          


Gln Tyr Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
        35                  40                  45  


<210>  53
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  53

Gly His Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Ala 
1               5                   10                  15      


Leu Arg Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala 
            20                  25                  30          


Gln Tyr Ser His Leu Gly Gly Asn Trp Ala Ala Asn Lys 
        35                  40                  45  


<210>  54
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  54

Gly Gln Asp Gly Val Arg Gln Ser Arg Ala Ser Asp Lys Gln Thr Leu 
1               5                   10                  15      


Leu Pro Asn Asp Gln Leu Tyr Gln Pro Leu Lys Asp Arg Glu Asp Asp 
            20                  25                  30          


Gln Tyr Ser His Leu Gln Gly Asn Gln Leu Arg Arg Asn 
        35                  40                  45  


<210>  55
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  55

Gly Gln Asp Gly Val Arg Gln Ser Arg Ala Ser Asp Lys Gln Thr Ala 
1               5                   10                  15      


Leu Pro Asn Asp Gln Leu Tyr Gln Pro Leu Lys Asp Arg Glu Asp Asp 
            20                  25                  30          


Gln Tyr Ser His Leu Gln Gly Asn Gln Leu Ala Arg Asn 
        35                  40                  45  


<210>  56
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  56

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  57
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  57

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr 
    


<210>  58
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  58

Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val 
1               5                   10                  15      


Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly 
            20                  25                  30          


Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu 
        35                  40                  45              


Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu 
    50                  55                  60                  


Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly 
65                  70                  75                  80  


Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val 
                85                  90                  95      


Cys Glu Asn Cys Met Glu Met Asp Gly Ser Ala Asp Asp Ala Lys Lys 
            100                 105                 110         


Asp Ala Ala Lys Lys Asp Asp Ala Lys Lys Asp Asp Ala Lys Lys Asp 
        115                 120                 125             


Gly Ser Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg Val Phe Val 
    130                 135                 140                 


Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val Gly Thr Leu 
145                 150                 155                 160 


Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile Leu Asp Pro 
                165                 170                 175     


Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys Asp Lys Glu 
            180                 185                 190         


Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys Val Glu Leu 
        195                 200                 205             


Asp Pro Ala Thr Val Ala 
    210                 


<210>  59
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  59

Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val 
1               5                   10                  15      


Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly 
            20                  25                  30          


Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu 
        35                  40                  45              


Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu 
    50                  55                  60                  


Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly 
65                  70                  75                  80  


Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val 
                85                  90                  95      


Cys Glu Asn Cys Met Glu Met Asp Gly Ser Ala Asp Asp Ala Lys Lys 
            100                 105                 110         


Asp Ala Ala Lys Lys Asp Asp Ala Lys Lys Asp Asp Ala Lys Lys Asp 
        115                 120                 125             


Gly Ser Gln Ser Ile Lys Gly Asn His Leu Val Lys Val Tyr Asp Tyr 
    130                 135                 140                 


Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala Glu Ala Lys Asn 
145                 150                 155                 160 


Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe Leu Thr Glu Asp 
                165                 170                 175     


Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp Pro Arg Gly Met 
            180                 185                 190         


Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro Leu Gln Val Tyr 
        195                 200                 205             


Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala Ala Thr Ile Ser 
    210                 215                 220                 


