
                                SEQUENCE LISTING

<110> Orentas, Rimas J.
      Dimitrov, Dimiter Stanchev
      Li, Wei
      Baek, Du-Sun
      

<120> CHIMERIC ANTIGEN RECEPTORS WHICH
  SPECIFICALLY BIND FIBROBLAST GROWTH FACTOR RECEPTOR 4
  

<130> SCRI.335WO

<150> 63089985            
<151> 2020-10-09  

<160> 311

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> E9 binder

<400> 1
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Ala Leu Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Tyr Ile Tyr His Lys Gly Asp Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Leu Val Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala
                85                  90                  95      
Lys Val Arg Trp Val Ser Ser Thr Ser Thr Leu Gly Phe Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120

<210> 2
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> A4 binder

<400> 2
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ile Ser Tyr
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Ala Ile Ile Tyr Pro Asp Asp Ala Gly Thr Met Tyr Ser Pro Ser Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys
                85                  90                  95      
Ala Arg Val Thr Met Val Arg Gly Val Ile Gly Phe Asp Pro Trp Gly
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120

<210> 3
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> E61 binder

<400> 3
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Tyr Pro Gly Asp Ser Asn Thr Ile Tyr Ser Pro Ser Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Gly Ala Tyr Asp Gly Arg Ile Trp Phe Asp Pro Trp Gly
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120

<210> 4
<211> 128
<212> PRT
<213> Artificial Sequence

<220> 
<223> A7 binder

<400> 4
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Tyr Ile Tyr His Thr Gly Asn Thr Tyr Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Glu Gly Val Met Gly Gly Tyr His Thr Asp Pro Asn Tyr Tyr Tyr
            100                 105                 110         
Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
        115                 120                 125

<210> 5
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> D92 binder

<400> 5
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Tyr Ser Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Leu Val Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Ala
                85                  90                  95      
Arg Asp Gly Ser Ser Trp Tyr Ser Phe Pro Tyr Tyr Tyr Gly Met Asp
            100                 105                 110         
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
        115                 120

<210> 6
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> D8 binder

<400> 6
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Ile
        35                  40                  45              
Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Arg
                85                  90                  95      
Gly Gly Trp Val Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
            100                 105                 110         
Ser

<210> 7
<211> 128
<212> PRT
<213> Artificial Sequence

<220> 
<223> F11 binder

<400> 7
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val
        35                  40                  45              
Ser Tyr Ile Ser Asn Gly Gly Gly Thr Met Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys
                85                  90                  95      
Thr Arg Ala Pro Tyr Cys Ser Gly Gly Asp Cys Tyr Pro Met Ser Thr
            100                 105                 110         
His Glu Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125

<210> 8
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> C52 binder

<400> 8
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Ser Tyr
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Val Ile Tyr Tyr Ser Gly Ala Thr Tyr Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Leu Val Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Gly Ala Leu Asp Tyr Phe Asp Leu Trp Gly Gln Gly Ala Leu Val
            100                 105                 110         
Thr Val Ser Ser
        115

<210> 9
<211> 254
<212> PRT
<213> Artificial Sequence

<220> 
<223> H4-VLVH binder

<400> 9
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln Ile Thr His Trp Pro His
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly
            100                 105                 110         
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val
        115                 120                 125             
Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser
    130                 135                 140                 
Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr Tyr Met Ser Trp Ile
145                 150                 155                 160 
Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Tyr Ile Ser Ser
                165                 170                 175     
Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr
            180                 185                 190         
Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser
        195                 200                 205             
Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Asp Ala Pro
    210                 215                 220                 
Asp Leu Leu Ala Val Pro Thr Val Ile Phe Ser Gly Tyr His Tyr Gly
225                 230                 235                 240 
Ala Asp Val Trp Gly Gln Gly Ala Thr Val Thr Val Ser Ser
                245                 250

<210> 10
<211> 254
<212> PRT
<213> Artificial Sequence

<220> 
<223> H4-VHVL binder

<400> 10
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
            20                  25                  30          
Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Ala Pro Asp Leu Leu Ala Val Pro Thr Val Ile Phe Ser
            100                 105                 110         
Gly Tyr His Tyr Gly Ala Asp Val Trp Gly Gln Gly Ala Thr Val Thr
        115                 120                 125             
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
    130                 135                 140                 
Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser
145                 150                 155                 160 
Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser
                165                 170                 175     
Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu
            180                 185                 190         
Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe
        195                 200                 205             
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu
    210                 215                 220                 
Gln Pro Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln Ile Thr His Trp
225                 230                 235                 240 
Pro His Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg
                245                 250

<210> 11
<211> 246
<212> PRT
<213> Artificial Sequence

<220> 
<223> G6-VLVH binder

<400> 11
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Tyr Gly Thr Phe Gly Gln
                85                  90                  95      
Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly
            100                 105                 110         
Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly
        115                 120                 125             
Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser
    130                 135                 140                 
Gly Phe Thr Phe Ser Asp Tyr Tyr Met Ser Trp Ile Arg Gln Ala Pro
145                 150                 155                 160 
Gly Lys Gly Leu Glu Trp Val Ser Tyr Ile Ser Ser Ser Gly Ser Thr
                165                 170                 175     
Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp
            180                 185                 190         
Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu
        195                 200                 205             
Asp Thr Ala Val Tyr Tyr Cys Ala Arg His Lys Thr Ser Leu Asn Asp
    210                 215                 220                 
Tyr Asp Phe Trp Ser Gly Tyr Leu Leu Asp Tyr Trp Gly Gln Gly Thr
225                 230                 235                 240 
Leu Val Thr Val Ser Ser
                245

<210> 12
<211> 246
<212> PRT
<213> Artificial Sequence

<220> 
<223> G6-VHVL binder

<400> 12
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
            20                  25                  30          
Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg His Lys Thr Ser Leu Asn Asp Tyr Asp Phe Trp Ser Gly Tyr
            100                 105                 110         
Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly
        115                 120                 125             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
    130                 135                 140                 
Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg
145                 150                 155                 160 
Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn
                165                 170                 175     
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala
            180                 185                 190         
Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly
        195                 200                 205             
Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp
    210                 215                 220                 
Ala Ala Thr Tyr Tyr Cys Gln His Tyr Gly Thr Phe Gly Gln Gly Thr
225                 230                 235                 240 
Lys Leu Glu Ile Lys Arg
                245

<210> 13
<211> 248
<212> PRT
<213> Artificial Sequence

<220> 
<223> C9-VLVH binder

<400> 13
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly
            100                 105                 110         
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val
        115                 120                 125             
Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser
    130                 135                 140                 
Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr Tyr Met Ser Trp Ile
145                 150                 155                 160 
Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Tyr Ile Ser Ser
                165                 170                 175     
Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr
            180                 185                 190         
Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser
        195                 200                 205             
Leu Arg Ala Glu Asp Thr Ala Lys Tyr Tyr Cys Ala Thr Ala Val Phe
    210                 215                 220                 
Ser Leu Gly Pro Glu Gly Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Lys
225                 230                 235                 240 
Gly Thr Thr Val Thr Val Ser Ser
                245

<210> 14
<211> 248
<212> PRT
<213> Artificial Sequence

<220> 
<223> C9-VHVL H binder

<400> 14
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
            20                  25                  30          
Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Lys Tyr Tyr Cys
                85                  90                  95      
Ala Thr Ala Val Phe Ser Leu Gly Pro Glu Gly Tyr Tyr Tyr Tyr Met
            100                 105                 110         
Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly
        115                 120                 125             
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met
    130                 135                 140                 
Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr
145                 150                 155                 160 
Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr
                165                 170                 175     
Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser
            180                 185                 190         
Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly
        195                 200                 205             
Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala
    210                 215                 220                 
Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro Thr Phe Gly Gln
225                 230                 235                 240 
Gly Thr Lys Leu Glu Ile Lys Arg
                245

<210> 15
<211> 247
<212> PRT
<213> Artificial Sequence

<220> 
<223> D7-VLVH binder

<400> 15
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Ile Ala Ala Tyr Tyr Cys Gln His Tyr Gly Thr Phe Gly Gln
                85                  90                  95      
Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly
            100                 105                 110         
Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly
        115                 120                 125             
Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser
    130                 135                 140                 
Gly Phe Thr Phe Ser Asp Tyr Tyr Met Ser Trp Ile Arg Gln Ala Pro
145                 150                 155                 160 
Gly Lys Gly Leu Glu Trp Val Ser Tyr Ile Ser Ser Ser Gly Ser Thr
                165                 170                 175     
Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp
            180                 185                 190         
Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu
        195                 200                 205             
Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Gly Tyr Pro Leu Gly Gly
    210                 215                 220                 
Gly Tyr Asp Phe Trp Ser Gly Tyr Tyr Pro Asp Tyr Trp Gly Gln Gly
225                 230                 235                 240 
Thr Leu Val Thr Val Ser Ser
                245

<210> 16
<211> 247
<212> PRT
<213> Artificial Sequence

<220> 
<223> D7-VHVL binder

<400> 16
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
            20                  25                  30          
Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Gly Tyr Pro Leu Gly Gly Gly Tyr Asp Phe Trp Ser Gly
            100                 105                 110         
Tyr Tyr Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp
    130                 135                 140                 
Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp
145                 150                 155                 160 
Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu
                165                 170                 175     
Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
            180                 185                 190         
Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
        195                 200                 205             
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu
    210                 215                 220                 
Asp Ile Ala Ala Tyr Tyr Cys Gln His Tyr Gly Thr Phe Gly Gln Gly
225                 230                 235                 240 
Thr Lys Leu Glu Ile Lys Arg
                245

<210> 17
<211> 246
<212> PRT
<213> Artificial Sequence

<220> 
<223> B7-VLVH binder

<400> 17
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Gly Thr Phe Gly Gln
                85                  90                  95      
Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly
            100                 105                 110         
Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly
        115                 120                 125             
Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser
    130                 135                 140                 
Gly Phe Thr Phe Ser Asp Tyr Tyr Met Ser Trp Ile Arg Gln Ala Pro
145                 150                 155                 160 
Gly Lys Gly Leu Glu Trp Val Ser Tyr Ile Ser Ser Ser Gly Ser Thr
                165                 170                 175     
Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp
            180                 185                 190         
Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu
        195                 200                 205             
Asp Thr Ala Met Tyr Tyr Cys Ala Arg His Lys Thr Ser Leu Asn Asp
    210                 215                 220                 
Tyr Asp Phe Trp Ser Gly Tyr Leu Leu Asp Tyr Trp Gly Gln Gly Thr
225                 230                 235                 240 
Leu Val Thr Val Ser Ser
                245

<210> 18
<211> 246
<212> PRT
<213> Artificial Sequence

<220> 
<223> B7-VHVL binder

<400> 18
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
            20                  25                  30          
Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg His Lys Thr Ser Leu Asn Asp Tyr Asp Phe Trp Ser Gly Tyr
            100                 105                 110         
Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly
        115                 120                 125             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
    130                 135                 140                 
Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg
145                 150                 155                 160 
Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn
                165                 170                 175     
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala
            180                 185                 190         
Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly
        195                 200                 205             
Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp
    210                 215                 220                 
Phe Ala Val Tyr Tyr Cys Gln His Tyr Gly Thr Phe Gly Gln Gly Thr
225                 230                 235                 240 
Lys Val Glu Ile Lys Arg
                245

<210> 19
<211> 246
<212> PRT
<213> Artificial Sequence

<220> 
<223> A6-VLVH binder

<400> 19
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Arg Tyr Gly Thr Phe Gly Gln
                85                  90                  95      
Gly Thr Lys Val Asp Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly
            100                 105                 110         
Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly
        115                 120                 125             
Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser
    130                 135                 140                 
Gly Phe Thr Phe Ser Asp Tyr Tyr Met Ser Trp Ile Arg Gln Ala Pro
145                 150                 155                 160 
Gly Lys Gly Leu Glu Trp Val Ser Tyr Ile Ser Ser Ser Gly Ser Thr
                165                 170                 175     
Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp
            180                 185                 190         
Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu
        195                 200                 205             
Asp Thr Ala Val Tyr Tyr Cys Ala Arg His Lys Thr Ser Leu Asn Asp
    210                 215                 220                 
Tyr Asp Phe Trp Ser Gly Tyr Leu Leu Asp Tyr Trp Gly Gln Gly Thr
225                 230                 235                 240 
Leu Val Thr Val Ser Ser
                245

<210> 20
<211> 246
<212> PRT
<213> Artificial Sequence

<220> 
<223> A6-VHVL binder

<400> 20
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
            20                  25                  30          
Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg His Lys Thr Ser Leu Asn Asp Tyr Asp Phe Trp Ser Gly Tyr
            100                 105                 110         
Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly
        115                 120                 125             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
    130                 135                 140                 
Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg
145                 150                 155                 160 
Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn
                165                 170                 175     
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala
            180                 185                 190         
Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly
        195                 200                 205             
Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp
    210                 215                 220                 
Ala Ala Thr Tyr Tyr Cys Gln Arg Tyr Gly Thr Phe Gly Gln Gly Thr
225                 230                 235                 240 
Lys Val Asp Ile Lys Arg
                245

<210> 21
<211> 245
<212> PRT
<213> Artificial Sequence

<220> 
<223> C1-VLVH binder

<400> 21
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Tyr Gly Thr Phe Gly Gln
                85                  90                  95      
Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly
            100                 105                 110         
Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly
        115                 120                 125             
Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser
    130                 135                 140                 
Gly Phe Thr Phe Ser Asp Tyr Tyr Met Ser Trp Ile Arg Gln Ala Pro
145                 150                 155                 160 
Gly Lys Gly Leu Glu Trp Val Ser Tyr Ile Ser Ser Ser Gly Ser Thr
                165                 170                 175     
Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp
            180                 185                 190         
Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu
        195                 200                 205             
Asp Thr Ala Val Tyr Tyr Cys Ala Arg His Ala Pro His Lys His Tyr
    210                 215                 220                 
Asp Phe Trp Ser Gly Tyr Tyr Pro Asp Tyr Trp Gly Gln Gly Thr Leu
225                 230                 235                 240 
Val Thr Val Ser Ser
                245

<210> 22
<211> 245
<212> PRT
<213> Artificial Sequence

<220> 
<223> C1-VHVL binder

<400> 22
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
            20                  25                  30          
Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg His Ala Pro His Lys His Tyr Asp Phe Trp Ser Gly Tyr Tyr
            100                 105                 110         
Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln
    130                 135                 140                 
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val
145                 150                 155                 160 
Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp
                165                 170                 175     
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala
            180                 185                 190         
Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser
        195                 200                 205             
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ala
    210                 215                 220                 
Ala Thr Tyr Tyr Cys Gln His Tyr Gly Thr Phe Gly Gln Gly Thr Lys
225                 230                 235                 240 
Val Glu Ile Lys Arg
                245

<210> 23
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Leader peptide

<400> 23
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro
            20

<210> 24
<211> 69
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD8 linker and transmembrane domains

<400> 24
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala
 1               5                  10                  15      
Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly
            20                  25                  30          
Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile
        35                  40                  45              
Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val
    50                  55                  60                  
Ile Thr Leu Tyr Cys
65

<210> 25
<211> 207
<212> DNA
<213> Artificial Sequence

<220> 
<223> CD8 linker and transmembrane domains

<400> 25
accactactc cggcacctag gccccccact ccggcaccga ccattgcatc acaaccactg 60
agtcttagac ctgaagcctg tcgacccgca gctggggggg cagtccacac acggggattg 120
gatttcgcct gcgatatata catttgggcg ccactggcag gcacctgcgg ggtcctgctc 180
ttgtcccttg tcatcaccct gtactgt                                     207

<210> 26
<211> 28
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD28tm

<400> 26
Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser
 1               5                  10                  15      
Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val
            20                  25

<210> 27
<211> 84
<212> DNA
<213> Artificial Sequence

<220> 
<223> CD28tm

<400> 27
atgttctggg tgctggtggt ggtcggaggc gtgctggcct gctacagcct gctggtcacc 60
gtggccttca tcatcttttg ggtg                                        84

<210> 28
<211> 41
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD28 cytoplasmic

<400> 28
Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr
 1               5                  10                  15      
Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro
            20                  25                  30          
Pro Arg Asp Phe Ala Ala Tyr Arg Ser
        35                  40

<210> 29
<211> 42
<212> PRT
<213> Artificial Sequence

<220> 
<223> 4-1BB signaling domain

<400> 29
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met
 1               5                  10                  15      
Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe
            20                  25                  30          
Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu
        35                  40

<210> 30
<211> 126
<212> DNA
<213> Artificial Sequence

<220> 
<223> 4-1BB signaling domain

<400> 30
aagagaggaa gaaagaagtt gttgtatatt ttcaaacagc cattcatgag gccggtccag 60
accactcagg aggaggatgg atgcagttgc cgctttccgg aagaggaaga gggtgggtgt 120
gaactc                                                            126

<210> 31
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD3-zeta chain signaling domain

<400> 31
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly
 1               5                  10                  15      
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr
            20                  25                  30          
Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys
        35                  40                  45              
Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys
    50                  55                  60                  
Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg
65                  70                  75                  80  
Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala
                85                  90                  95      
Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
            100                 105                 110

<210> 32
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<223> CD3-zeta chain signaling domain

<400> 32
cgagttaaat tttctcgcag tgctgatgcc ccagcgtata aacagggtca gaaccaactg 60
tataatgaac tcaatttggg gaggcgagag gagtatgatg tattggacaa gcggcggggg 120
cgggatcctg aaatgggcgg taagccaagg cgcaagaatc cacaggaggg tttgtataat 180
gagttgcaga aggataaaat ggcggaagcg tattcagaaa tcggaatgaa gggagagcgc 240
cgcagaggga aagggcatga tggcctctac caaggtttgt caacagcgac caaggatacc 300
tatgacgcac ttcatatgca agcactgccc cccagg                           336

<210> 33
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> T2A

<400> 33
ctcgagggcg gcggagaggg cagaggaagt cttctaacat gcggtgacgt ggaggagaat 60
cccggcccta gg                                                     72

<210> 34
<211> 1005
<212> DNA
<213> Artificial Sequence

<220> 
<223> EGFRt

<400> 34
cgcaaagtgt gtaacggaat aggtattggt gaatttaaag actcactctc cataaatgct 60
acgaatatta aacacttcaa aaactgcacc tccatcagtg gcgatctcca catcctgccg 120
gtggcattta ggggtgactc cttcacacat actcctcctc tggatccaca ggaactggat 180
attctgaaaa ccgtaaagga aatcacaggg tttttgctga ttcaggcttg gcctgaaaac 240
aggacggacc tccatgcctt tgagaaccta gaaatcatac gcggcaggac caagcaacat 300
ggtcagtttt ctcttgcagt cgtcagcctg aacataacat ccttgggatt acgctccctc 360
aaggagataa gtgatggaga tgtgataatt tcaggaaaca aaaatttgtg ctatgcaaat 420
acaataaact ggaaaaaact gtttgggacc tccggtcaga aaaccaaaat tataagcaac 480
agaggtgaaa acagctgcaa ggccacaggc caggtctgcc atgccttgtg ctcccccgag 540
ggctgctggg gcccggagcc cagggactgc gtctcttgcc ggaatgtcag ccgaggcagg 600
gaatgcgtgg acaagtgcaa ccttctggag ggtgagccaa gggagtttgt ggagaactct 660
gagtgcatac agtgccaccc agagtgcctg cctcaggcca tgaacatcac ctgcacagga 720
cggggaccag acaactgtat ccagtgtgcc cactacattg acggccccca ctgcgtcaag 780
acctgcccgg caggagtcat gggagaaaac aacaccctgg tctggaagta cgcagacgcc 840
ggccatgtgt gccacctgtg ccatccaaac tgcacctacg gatgcactgg gccaggtctt 900
gaaggctgtc caacgaatgg gcctaagatc ccgtccatcg ccactgggat ggtgggggcc 960
ctcctcttgc tgctggtggt ggccctgggg atcggcctct tcatg                 1005

<210> 35
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> S (small) spacer

<400> 35
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro
 1               5                  10

<210> 36
<211> 36
<212> PRT
<213> Artificial Sequence

<220> 
<223> S (small) spacer

<400> 36
Gly Ala Ala Thr Cys Thr Ala Ala Gly Thr Ala Cys Gly Gly Ala Cys
 1               5                  10                  15      
Cys Gly Cys Cys Cys Thr Gly Cys Cys Cys Cys Cys Cys Thr Thr Gly
            20                  25                  30          
Cys Cys Cys Thr
        35

<210> 37
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> M (medium) spacer

<400> 37
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gln Pro Arg
 1               5                  10                  15      
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys
            20                  25                  30          
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
        35                  40                  45              
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
    50                  55                  60                  
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
65                  70                  75                  80  
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser
                85                  90                  95      
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
            100                 105                 110         
Leu Ser Leu Ser Leu Gly Lys
        115

<210> 38
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> M (medium) spacer

<400> 38
gaatctaagt acggaccgcc ctgcccccct tgccctggcc agcctagaga accccaggtg 60
tacaccctgc ctcccagcca ggaagagatg accaagaacc aggtgtccct gacctgcctg 120
gtcaaaggct tctaccccag cgatatcgcc gtggaatggg agagcaacgg ccagcccgag 180
aacaactaca agaccacccc ccctgtgctg gacagcgacg gcagcttctt cctgtactcc 240
cggctgaccg tggacaagag ccggtggcag gaaggcaacg tcttcagctg cagcgtgatg 300
cacgaggccc tgcacaacca ctacacccag aagtccctga gcctgagcct gggcaag    357

<210> 39
<211> 229
<212> PRT
<213> Artificial Sequence

<220> 
<223> L (long) spacer

<400> 39
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe
 1               5                  10                  15      
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
            20                  25                  30          
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
        35                  40                  45              
Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val
    50                  55                  60                  
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser
65                  70                  75                  80  
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
                85                  90                  95      
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser
            100                 105                 110         
Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
        115                 120                 125             
Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln
    130                 135                 140                 
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
145                 150                 155                 160 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
                165                 170                 175     
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu
            180                 185                 190         
Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser
        195                 200                 205             
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
    210                 215                 220                 
Leu Ser Leu Gly Lys
225

<210> 40
<211> 687
<212> DNA
<213> Artificial Sequence

<220> 
<223> L (long) spacer

<400> 40
gaatctaagt acggaccgcc ctgcccccct tgccctgccc ccgagttcga cggcggaccc 60
agcgtgttcc tgttcccccc caagcccaag gacaccctga tgatcagccg gacccccgag 120
gtgacctgcg tggtggtgga cgtgagccag gaagatcccg aggtccagtt caattggtac 180
gtggacggcg tggaagtgca caacgccaag accaagccca gagaggaaca gttccagagc 240
acctaccggg tggtgtctgt gctgaccgtg ctgcaccagg actggctgaa cggcaaagaa 300
tacaagtgca aggtgtccaa caagggcctg cccagcagca tcgaaaagac catcagcaag 360
gccaagggcc agcctcgcga gccccaggtg tacaccctgc ctccctccca ggaagagatg 420
accaagaacc aggtgtccct gacctgcctg gtgaagggct tctaccccag cgacatcgcc 480
gtggagtggg agagcaacgg ccagcctgag aacaactaca agaccacccc tcccgtgctg 540
gacagcgacg gcagcttctt cctgtacagc cggctgaccg tggacaagag ccggtggcag 600
gaaggcaacg tctttagctg cagcgtgatg cacgaggccc tgcacaacca ctacacccag 660
aagagcctga gcctgtccct gggcaag                                     687

<210> 41
<211> 361
<212> PRT
<213> Artificial Sequence

<220> 
<223> RJ146 CAR (D8/CD8 TM/4-1BB/CD3zeta)

<400> 41
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly
            20                  25                  30          
Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly
        35                  40                  45              
Phe Thr Phe Ser Asn Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly
    50                  55                  60                  
Lys Ala Leu Glu Trp Ile Gly Glu Ile Asn His Ser Gly Ser Thr Asn
65                  70                  75                  80  
Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Arg Asp Asn Ser
                85                  90                  95      
Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr
            100                 105                 110         
Ala Ile Tyr Tyr Cys Arg Gly Gly Trp Val Gly Tyr Trp Gly Gln Gly
        115                 120                 125             
Thr Leu Val Thr Val Ser Ser Ala Ala Ala Thr Thr Thr Pro Ala Pro
    130                 135                 140                 
Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu
145                 150                 155                 160 
Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg
                165                 170                 175     
Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly
            180                 185                 190         
Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys
        195                 200                 205             
Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg
    210                 215                 220                 
Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro
225                 230                 235                 240 
Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser
                245                 250                 255     
Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu
            260                 265                 270         
Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg
        275                 280                 285             
Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln
    290                 295                 300                 
Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr
305                 310                 315                 320 
Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp
                325                 330                 335     
Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala
            340                 345                 350         
Leu His Met Gln Ala Leu Pro Pro Arg
        355                 360

<210> 42
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> E9 binder

<400> 42
Ser Tyr Ala Leu Gly
 1               5

<210> 43
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> E9 binder

<400> 43
Tyr Ile Tyr His Lys Gly Asp Thr Asn Tyr Asn Pro Ser Leu Lys Ser
 1               5                  10                  15

<210> 44
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> E9 binder

<400> 44
Val Arg Trp Val Ser Ser Thr Ser Thr Leu Gly Phe Asp Tyr
 1               5                  10

<210> 45
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> A4 binder

<400> 45
Ser Tyr Ala Met Ser
 1               5

<210> 46
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> A4 binder

<400> 46
Ile Ile Tyr Pro Asp Asp Ala Gly Thr Met Tyr Ser Pro Ser Phe Gln
 1               5                  10                  15      
Gly

<210> 47
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> A4 binder

<400> 47
Val Thr Met Val Arg Gly Val Ile Gly Phe Asp Pro
 1               5                  10

<210> 48
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> E61 binder

<400> 48
Ser Tyr Ala Met Ser
 1               5

<210> 49
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> E61 binder

<400> 49
Met Gly Ile Ile Tyr Pro Gly Asp Ser Asn Thr Ile Tyr Ser Pro Ser
 1               5                  10                  15      
Phe Gln Gly

<210> 50
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> E61 binder

<400> 50
Ser Gly Ala Tyr Asp Gly Arg Ile Trp Phe Asp Pro
 1               5                  10

<210> 51
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> A7 binder

<400> 51
Asn Tyr Gly Met Ser
 1               5

<210> 52
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> A7 binder

<400> 52
Tyr Ile Tyr His Thr Gly Asn Thr Tyr Tyr Asn Pro Ser Leu Lys Ser
 1               5                  10                  15

<210> 53
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> A7 binder

<400> 53
Glu Gly Val Met Gly Gly Tyr His Thr Asp Pro Asn Tyr Tyr Tyr Tyr
 1               5                  10                  15      
Gly Met Asp Val
            20

<210> 54
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> D92 binder

<400> 54
Ser Tyr Gly Met His
 1               5

<210> 55
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> D92 binder

<400> 55
Tyr Ser Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser
 1               5                  10                  15

<210> 56
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> D92 binder

<400> 56
Asp Gly Ser Ser Trp Tyr Ser Phe Pro Tyr Tyr Tyr Gly Met Asp Val
 1               5                  10                  15

<210> 57
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> D8 binder

<400> 57
Asn Tyr Gly Met Ser
 1               5

<210> 58
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> D8 binder

<400> 58
Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser
 1               5                  10                  15

<210> 59
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> D8 binder

<400> 59
Arg Gly Gly Trp Val Gly Tyr
 1               5

<210> 60
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> F11 binder

<400> 60
Asn Tyr Gly Met Ser
 1               5

<210> 61
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> F11 binder

<400> 61
Tyr Ile Ser Asn Gly Gly Gly Thr Met Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly

<210> 62
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> F11 binder

<400> 62
Thr Arg Ala Pro Tyr Cys Ser Gly Gly Asp Cys Tyr Pro Met Ser Thr
 1               5                  10                  15      
His Glu Leu Asp Ser
            20

<210> 63
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> C52 binder

<400> 63
Ser Tyr Trp Met Ser
 1               5

<210> 64
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> C52 binder

<400> 64
Val Ile Tyr Tyr Ser Gly Ala Thr Tyr Tyr Asn Pro Ser Leu Lys Ser
 1               5                  10                  15

<210> 65
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> C52 binder

<400> 65
Gly Ala Leu Asp Tyr Phe Asp Leu
 1               5

<210> 66
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> H4-VLVH binder

<400> 66
Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn
 1               5                  10

<210> 67
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> H4-VLVH binder

<400> 67
Ala Ala Ser Ser Leu Gln Ser
 1               5

<210> 68
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> H4-VLVH binder

<400> 68
Leu Gln Ile Thr His Trp Pro His Thr
 1               5

<210> 69
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> H4-VLVH binder

<400> 69
Asp Tyr Tyr Met Ser
 1               5

<210> 70
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> H4-VLVH binder

<400> 70
Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly

<210> 71
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> H4-VLVH binder

<400> 71
Asp Ala Pro Asp Leu Leu Ala Val Pro Thr Val Ile Phe Ser Gly Tyr
 1               5                  10                  15      
His Tyr Gly Ala Asp Val
            20

<210> 72
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> H4-VHVL binder

<400> 72
Asp Tyr Tyr Met Ser
 1               5

<210> 73
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> H4-VHVL binder

<400> 73
Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly

<210> 74
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Binder H4-VHVL

<400> 74
Asp Ala Pro Asp Leu Leu Ala Val Pro Thr Val Ile Phe Ser Gly Tyr
 1               5                  10                  15      
His Tyr Gly Ala Asp Val
            20

<210> 75
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> H4-VHVL binder

<400> 75
Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn
 1               5                  10

<210> 76
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> H4-VHVL binder

<400> 76
Ala Ala Ser Ser Leu Gln Ser
 1               5

<210> 77
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> H4-VHVL binder

<400> 77
Leu Gln Ile Thr His Trp Pro His Thr
 1               5

<210> 78
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> G6-VLVH binder

<400> 78
Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn
 1               5                  10

<210> 79
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> G6-VLVH binder

<400> 79
Ala Ala Ser Ser Leu Gln Ser
 1               5

<210> 80
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> G6-VLVH binder

<400> 80
Gln His Tyr Gly Thr
 1               5

<210> 81
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> G6-VLVH binder

<400> 81
Asp Tyr Tyr Met Ser
 1               5

<210> 82
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> G6-VLVH binder

<400> 82
Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly

<210> 83
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> G6-VLVH binder

<400> 83
His Lys Thr Ser Leu Asn Asp Tyr Asp Phe Trp Ser Gly Tyr Leu Leu
 1               5                  10                  15      
Asp Tyr

<210> 84
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> G6-VHVL binder

<400> 84
Asp Tyr Tyr Met Ser
 1               5

<210> 85
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> G6-VHVL binder

<400> 85
Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly

<210> 86
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> G6-VHVL binder

<400> 86
His Lys Thr Ser Leu Asn Asp Tyr Asp Phe Trp Ser Gly Tyr Leu Leu
 1               5                  10                  15      
Asp Tyr

<210> 87
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> G6-VHVL binder

<400> 87
Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn
 1               5                  10

<210> 88
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> G6-VHVL binder

<400> 88
Ala Ala Ser Ser Leu Gln Ser
 1               5

<210> 89
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> G6-VHVL binder

<400> 89
Gln His Tyr Gly Thr
 1               5

<210> 90
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> C9-VLVH binder

<400> 90
Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn
 1               5                  10

<210> 91
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> C9-VLVH binder

<400> 91
Ala Ala Ser Ser Leu Gln Ser
 1               5

<210> 92
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> C9-VLVH binder

<400> 92
Gln Gln Arg Ser Asn Trp Pro Pro Thr
 1               5

<210> 93
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> C9-VLVH binder

<400> 93
Asp Tyr Tyr Met Ser
 1               5

<210> 94
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> C9-VLVH binder

<400> 94
Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly

<210> 95
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> C9-VLVH binder

<400> 95
Ala Val Phe Ser Leu Gly Pro Glu Gly Tyr Tyr Tyr Tyr Met Asp Val
 1               5                  10                  15

<210> 96
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> C9-VHVL H binder

<400> 96
Asp Tyr Tyr Met Ser
 1               5

<210> 97
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> C9-VHVL H binder

<400> 97
Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly

<210> 98
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> C9-VHVL H binder

<400> 98
Ala Val Phe Ser Leu Gly Pro Glu Gly Tyr Tyr Tyr Tyr Met Asp Val
 1               5                  10                  15

<210> 99
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> C9-VHVL H binder

<400> 99
Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn
 1               5                  10

<210> 100
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> C9-VHVL H binder

<400> 100
Ala Ala Ser Ser Leu Gln Ser
 1               5 

<210> 101
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> C9-VHVL H binder

<400> 101
Gln Gln Arg Ser Asn Trp Pro Pro Thr
 1               5

<210> 102
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> D7-VLVH binder

<400> 102
Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn
 1               5                  10

<210> 103
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> D7-VLVH binder

<400> 103
Ala Ala Ser Ser Leu Gln Ser
 1               5

<210> 104
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> D7-VLVH binder

<400> 104
Gln His Tyr Gly Thr
 1               5

<210> 105
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> D7-VLVH binder

<400> 105
Asp Tyr Tyr Met Ser
 1               5

<210> 106
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> D7-VLVH binder

<400> 106
Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly

<210> 107
<211> 19
<212> PRT
<213> `Artificial Sequence

<220> 
<223> D7-VLVH binder

<400> 107
Asp Gly Tyr Pro Leu Gly Gly Gly Tyr Asp Phe Trp Ser Gly Tyr Tyr
 1               5                  10                  15      
Pro Asp Tyr

<210> 108
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> D7-VHVL binder

<400> 108
Asp Tyr Tyr Met Ser
 1               5

<210> 109
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> D7-VHVL binder

<400> 109
Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly

<210> 110
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> D7-VHVL binder

<400> 110
Asp Gly Tyr Pro Leu Gly Gly Gly Tyr Asp Phe Trp Ser Gly Tyr Tyr
 1               5                  10                  15      
Pro Asp Tyr

<210> 111
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> D7-VHVL binder

<400> 111
Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn
 1               5                  10

<210> 112
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> D7-VHVL binder

<400> 112
Ala Ala Ser Ser Leu Gln Ser
 1               5

<210> 113
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> D7-VHVL binder

<400> 113
Gln His Tyr Gly Thr
 1               5

<210> 114
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> B7-VLVH binder

<400> 114
Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn
 1               5                  10

<210> 115
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> B7-VLVH binder

<400> 115
Ala Ala Ser Ser Leu Gln Ser
 1               5

<210> 116
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> B7-VLVH binder

<400> 116
Gln His Tyr Gly Thr
 1               5

<210> 117
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> B7-VLVH binder

<400> 117
Asp Tyr Tyr Met Ser
 1               5

<210> 118
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> B7-VLVH binder

<400> 118
Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly

<210> 119
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> B7-VLVH binder

<400> 119
His Lys Thr Ser Leu Asn Asp Tyr Asp Phe Trp Ser Gly Tyr Leu Leu
 1               5                  10                  15      
Asp Tyr

<210> 120
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> B7-VHVL binder

<400> 120
Asp Tyr Tyr Met Ser
 1               5

<210> 121
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> B7-VHVL binder

<400> 121
Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly

<210> 122
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> B7-VHVL binder

<400> 122
His Lys Thr Ser Leu Asn Asp Tyr Asp Phe Trp Ser Gly Tyr Leu Leu
 1               5                  10                  15      
Asp Tyr

<210> 123
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> B7-VHVL binder

<400> 123
Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn
 1               5                  10

<210> 124
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> B7-VHVL binder

<400> 124
Ala Ala Ser Ser Leu Gln Ser
 1               5

<210> 125
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> B7-VHVL binder

<400> 125
Gln His Tyr Gly Thr
 1               5

<210> 126
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> A6-VLVH binder

<400> 126
Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn
 1               5                  10

<210> 127
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> A6-VLVH binder

<400> 127
Ala Ala Ser Ser Leu Gln Ser
 1               5

<210> 128
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> A6-VLVH binder

<400> 128
Gln Arg Tyr Gly Thr
 1               5

<210> 129
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> A6-VLVH binder

<400> 129
Asp Tyr Tyr Met Ser
 1               5

<210> 130
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> A6-VLVH binder

<400> 130
Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly

<210> 131
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> A6-VLVH binder

<400> 131
His Lys Thr Ser Leu Asn Asp Tyr Asp Phe Trp Ser Gly Tyr Leu Leu
 1               5                  10                  15      
Asp Tyr

<210> 132
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> A6-VHVL binder

<400> 132
Asp Tyr Tyr Met Ser
 1               5 

<210> 133
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> A6-VHVL binder

<400> 133
Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly

<210> 134
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> A6-VHVL binder

<400> 134
His Lys Thr Ser Leu Asn Asp Tyr Asp Phe Trp Ser Gly Tyr Leu Leu
 1               5                  10                  15      
Asp Tyr

<210> 135
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> A6-VHVL binder

<400> 135
Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn
 1               5                  10

<210> 136
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> A6-VHVL binder

<400> 136
Ala Ala Ser Ser Leu Gln Ser
 1               5

<210> 137
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> A6-VHVL binder

<400> 137
Gln Arg Tyr Gly Thr
 1               5

<210> 138
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> C1-VLVH binder

<400> 138
Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn
 1               5                  10

<210> 139
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> C1-VLVH binder

<400> 139
Ala Ala Ser Ser Leu Gln Ser
 1               5

<210> 140
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> C1-VLVH binder

<400> 140
Gln His Tyr Gly Thr
 1               5

<210> 141
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> C1-VLVH binder

<400> 141
Asp Tyr Tyr Met Ser
 1               5

<210> 142
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> C1-VLVH binder

<400> 142
Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly

<210> 143
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> C1-VLVH binder

<400> 143
His Ala Pro His Lys His Tyr Asp Phe Trp Ser Gly Tyr Tyr Pro Asp
 1               5                  10                  15      
Tyr

<210> 144
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> C1-VHVL binder

<400> 144
Asp Tyr Tyr Met Ser
 1               5

<210> 145
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> C1-VHVL binder

<400> 145
Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly

<210> 146
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> C1-VHVL binder

<400> 146
His Ala Pro His Lys His Tyr Asp Phe Trp Ser Gly Tyr Tyr Pro Asp
 1               5                  10                  15      
Tyr

<210> 147
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> C1-VHVL binder

<400> 147
Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn
 1               5                  10

<210> 148
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> C1-VHVL binder

<400> 148
Ala Ala Ser Ser Leu Gln Ser
 1               5

<210> 149
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> C1-VHVL binder

<400> 149
Gln His Tyr Gly Thr
 1               5

<210> 150
<211> 366
<212> DNA
<213> Artificial Sequence

<220> 
<223> E9 binder

<400> 150
gaggtgcagc tggttgaatc tggcggagga ctggttcagc ctggcggatc tctgagactg 60
agctgtaccg tgtccggctt caccttcagc tcttatgccc tcggctgggt ccgacaggct 120
cctggaaaag gactggaatg gatcggctac atctaccaca agggcgacac caactacaac 180
cccagcctga agtccctggt caccatcagc agagacaaca gcaagaacac cctgtacctg 240
cagatgaaca gcctgagagc cgaggacaca gccctgtact actgcgccaa agtccgctgg 300
gtgtccagca caagcaccct gggctttgat tattggggcc agggcacact ggtcaccgtg 360
tcatct                                                            366

<210> 151
<211> 370
<212> PRT
<213> Artificial Sequence

<220> 
<223> RJ141 CAR: (E9/CD8 TM/4-1BB/CD3zeta)

<400> 151
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly
            20                  25                  30          
Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Val Ser Gly
        35                  40                  45              
Phe Thr Phe Ser Ser Tyr Ala Leu Gly Trp Val Arg Gln Ala Pro Gly
    50                  55                  60                  
Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr His Lys Gly Asp Thr Asn
65                  70                  75                  80  
Tyr Asn Pro Ser Leu Lys Ser Leu Val Thr Ile Ser Arg Asp Asn Ser
                85                  90                  95      
Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr
            100                 105                 110         
Ala Leu Tyr Tyr Cys Ala Lys Val Arg Trp Val Ser Ser Thr Ser Thr
        115                 120                 125             
Leu Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
    130                 135                 140                 
Ala Ala Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro
145                 150                 155                 160 
Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro
                165                 170                 175     
Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp
            180                 185                 190         
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu
        195                 200                 205             
Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu
    210                 215                 220                 
Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu
225                 230                 235                 240 
Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys
                245                 250                 255     
Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys
            260                 265                 270         
Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu
        275                 280                 285             
Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly
    290                 295                 300                 
Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu
305                 310                 315                 320 
Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly
                325                 330                 335     
Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser
            340                 345                 350         
Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro
        355                 360                 365             
Pro Arg
    370

<210> 152
<211> 1110
<212> DNA
<213> Artificial Sequence

<220> 
<223> RJ141 CAR: (E9/CD8 TM/4-1BB/CD3zeta)

<400> 152
atgcttctgc tcgtgacaag cctgctgctg tgcgagctgc cccaccctgc ctttctgctg 60
atccctgagg tgcagctggt tgaatctggc ggaggactgg ttcagcctgg cggatctctg 120
agactgagct gtaccgtgtc cggcttcacc ttcagctctt atgccctcgg ctgggtccga 180
caggctcctg gaaaaggact ggaatggatc ggctacatct accacaaggg cgacaccaac 240
tacaacccca gcctgaagtc cctggtcacc atcagcagag acaacagcaa gaacaccctg 300
tacctgcaga tgaacagcct gagagccgag gacacagccc tgtactactg cgccaaagtc 360
cgctgggtgt ccagcacaag caccctgggc tttgattatt ggggccaggg cacactggtc 420
accgtgtcat ctgcggccgc aaccactact ccggcaccta ggccccccac tccggcaccg 480
accattgcat cacaaccact gagtcttaga cctgaagcct gtcgacccgc agctgggggg 540
gcagtccaca cacggggatt ggatttcgcc tgcgatatat acatttgggc gccactggca 600
ggcacctgcg gggtcctgct cttgtccctt gtcatcaccc tgtactgtaa gagaggaaga 660
aagaagttgt tgtatatttt caaacagcca ttcatgaggc cggtccagac cactcaggag 720
gaggatggat gcagttgccg ctttccggaa gaggaagagg gtgggtgtga actccgagtt 780
aaattttctc gcagtgctga tgccccagcg tataaacagg gtcagaacca actgtataat 840
gaactcaatt tggggaggcg agaggagtat gatgtattgg acaagcggcg ggggcgggat 900
cctgaaatgg gcggtaagcc aaggcgcaag aatccacagg agggtttgta taatgagttg 960
cagaaggata aaatggcgga agcgtattca gaaatcggaa tgaagggaga gcgccgcaga 1020
gggaaagggc atgatggcct ctaccaaggt ttgtcaacag cgaccaagga tacctatgac 1080
gcacttcata tgcaagcact gccccccagg                                  1110

<210> 153
<211> 363
<212> DNA
<213> Artificial Sequence

<220> 
<223> A4 binder

<400> 153
gaggtgcagc tggttgaatc tggcggagga ctggttcagc ctggcggatc tctgagactg 60
agctgtgtgg ccagcggctt caccttcatc agctacgcca tgagctgggt ccgacaggcc 120
cctggaaaag gccttgagtg gatggccatt atctaccccg atgacgccgg caccatgtac 180
agccctagct ttcagggcca agtgaccatc agccgggaca acagcaagaa caccctgtac 240
ctgcagatga acagcctgag agccgaggac acagccctgt actactgtgc cagagtgaca 300
atggtccgag gcgtgatcgg cttcgatcct tggggacagg gaaccctggt caccgtttct 360
tct                                                               363

<210> 154
<211> 369
<212> PRT
<213> Artificial Sequence

<220> 
<223> RJ142 CAR (A4/CD8 TM/4-1BB/CD3zeta)

<400> 154
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly
            20                  25                  30          
Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly
        35                  40                  45              
Phe Thr Phe Ile Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly
    50                  55                  60                  
Lys Gly Leu Glu Trp Met Ala Ile Ile Tyr Pro Asp Asp Ala Gly Thr
65                  70                  75                  80  
Met Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Arg Asp Asn
                85                  90                  95      
Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
            100                 105                 110         
Thr Ala Leu Tyr Tyr Cys Ala Arg Val Thr Met Val Arg Gly Val Ile
        115                 120                 125             
Gly Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala
    130                 135                 140                 
Ala Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr
145                 150                 155                 160 
Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala
                165                 170                 175     
Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile
            180                 185                 190         
Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser
        195                 200                 205             
Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr
    210                 215                 220                 
Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu
225                 230                 235                 240 
Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu
                245                 250                 255     
Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln
            260                 265                 270         
Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu
        275                 280                 285             
Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly
    290                 295                 300                 
Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln
305                 310                 315                 320 
Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu
                325                 330                 335     
Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr
            340                 345                 350         
Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro
        355                 360                 365             
Arg

<210> 155
<211> 1107
<212> DNA
<213> Artificial Sequence

<220> 
<223> RJ142 CAR (A4/CD8 TM/4-1BB/CD3zeta)

<400> 155
atgcttctgc tcgtgacaag cctgctgctg tgcgagctgc cccaccctgc ctttctgctg 60
atccctgagg tgcagctggt tgaatctggc ggaggactgg ttcagcctgg cggatctctg 120
agactgagct gtgtggccag cggcttcacc ttcatcagct acgccatgag ctgggtccga 180
caggcccctg gaaaaggcct tgagtggatg gccattatct accccgatga cgccggcacc 240
atgtacagcc ctagctttca gggccaagtg accatcagcc gggacaacag caagaacacc 300
ctgtacctgc agatgaacag cctgagagcc gaggacacag ccctgtacta ctgtgccaga 360
gtgacaatgg tccgaggcgt gatcggcttc gatccttggg gacagggaac cctggtcacc 420
gtttcttctg cggccgcaac cactactccg gcacctaggc cccccactcc ggcaccgacc 480
attgcatcac aaccactgag tcttagacct gaagcctgtc gacccgcagc tgggggggca 540
gtccacacac ggggattgga tttcgcctgc gatatataca tttgggcgcc actggcaggc 600
acctgcgggg tcctgctctt gtcccttgtc atcaccctgt actgtaagag aggaagaaag 660
aagttgttgt atattttcaa acagccattc atgaggccgg tccagaccac tcaggaggag 720
gatggatgca gttgccgctt tccggaagag gaagagggtg ggtgtgaact ccgagttaaa 780
ttttctcgca gtgctgatgc cccagcgtat aaacagggtc agaaccaact gtataatgaa 840
ctcaatttgg ggaggcgaga ggagtatgat gtattggaca agcggcgggg gcgggatcct 900
gaaatgggcg gtaagccaag gcgcaagaat ccacaggagg gtttgtataa tgagttgcag 960
aaggataaaa tggcggaagc gtattcagaa atcggaatga agggagagcg ccgcagaggg 1020
aaagggcatg atggcctcta ccaaggtttg tcaacagcga ccaaggatac ctatgacgca 1080
cttcatatgc aagcactgcc ccccagg                                     1107

<210> 156
<211> 363
<212> DNA
<213> Artificial Sequence

<220> 
<223> E61 binder

<400> 156
gaggtgcagc tggttgaatc tggcggagga ctggttcagc ctggcggatc tctgagactg 60
tcctgcacct tcagcggctt caccttctcc agctacgcca tgagctgggt ccgacaggct 120
cctggcaaag gccttgagtg gatgggcatc atctaccccg gcgacagcaa caccatctac 180
agccctagct tccagggcca agtgaccatc agccgggaca acagcaagaa caccctgtac 240
ctgcagatga acagcctgag agccgaggac accgccacct actactgtgc tagaagcggc 300
gcctacgacg gccggatttg gtttgatcct tggggccagg gcaccctggt cacagtttct 360
tct                                                               363

<210> 157
<211> 369
<212> PRT
<213> Artificial Sequence

<220> 
<223> RJ143 CAR (E61/CD8 TM/4-1BB/CD3zeta)

<400> 157
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly
            20                  25                  30          
Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly
        35                  40                  45              
Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly
    50                  55                  60                  
Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asn Thr
65                  70                  75                  80  
Ile Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Arg Asp Asn
                85                  90                  95      
Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
            100                 105                 110         
Thr Ala Thr Tyr Tyr Cys Ala Arg Ser Gly Ala Tyr Asp Gly Arg Ile
        115                 120                 125             
Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala
    130                 135                 140                 
Ala Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr
145                 150                 155                 160 
Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala
                165                 170                 175     
Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile
            180                 185                 190         
Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser
        195                 200                 205             
Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr
    210                 215                 220                 
Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu
225                 230                 235                 240 
Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu
                245                 250                 255     
Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln
            260                 265                 270         
Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu
        275                 280                 285             
Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly
    290                 295                 300                 
Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln
305                 310                 315                 320 
Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu
                325                 330                 335     
Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr
            340                 345                 350         
Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro
        355                 360                 365             
Arg

<210> 158
<211> 1107
<212> DNA
<213> Artificial Sequence

<220> 
<223> RJ143 CAR (E61/CD8 TM/4-1BB/CD3zeta)

<400> 158
atgcttctgc tcgtgacaag cctgctgctg tgcgagctgc cccaccctgc ctttctgctg 60
atccctgagg tgcagctggt tgaatctggc ggaggactgg ttcagcctgg cggatctctg 120
agactgtcct gcaccttcag cggcttcacc ttctccagct acgccatgag ctgggtccga 180
caggctcctg gcaaaggcct tgagtggatg ggcatcatct accccggcga cagcaacacc 240
atctacagcc ctagcttcca gggccaagtg accatcagcc gggacaacag caagaacacc 300
ctgtacctgc agatgaacag cctgagagcc gaggacaccg ccacctacta ctgtgctaga 360
agcggcgcct acgacggccg gatttggttt gatccttggg gccagggcac cctggtcaca 420
gtttcttctg cggccgcaac cactactccg gcacctaggc cccccactcc ggcaccgacc 480
attgcatcac aaccactgag tcttagacct gaagcctgtc gacccgcagc tgggggggca 540
gtccacacac ggggattgga tttcgcctgc gatatataca tttgggcgcc actggcaggc 600
acctgcgggg tcctgctctt gtcccttgtc atcaccctgt actgtaagag aggaagaaag 660
aagttgttgt atattttcaa acagccattc atgaggccgg tccagaccac tcaggaggag 720
gatggatgca gttgccgctt tccggaagag gaagagggtg ggtgtgaact ccgagttaaa 780
ttttctcgca gtgctgatgc cccagcgtat aaacagggtc agaaccaact gtataatgaa 840
ctcaatttgg ggaggcgaga ggagtatgat gtattggaca agcggcgggg gcgggatcct 900
gaaatgggcg gtaagccaag gcgcaagaat ccacaggagg gtttgtataa tgagttgcag 960
aaggataaaa tggcggaagc gtattcagaa atcggaatga agggagagcg ccgcagaggg 1020
aaagggcatg atggcctcta ccaaggtttg tcaacagcga ccaaggatac ctatgacgca 1080
cttcatatgc aagcactgcc ccccagg                                     1107

<210> 159
<211> 384
<212> DNA
<213> Artificial Sequence

<220> 
<223> A7 binder

<400> 159
gaggtgcagc tggttgaatc tggcggagga ctggttcagc ctggcggatc tctgagactg 60
tcttgtgccg ccagcggctt caccttcagc aactacggca tgagctgggt ccgacaggcc 120
cctggaaaag gccttgagtg gatcggctac atctaccaca ccggcaacac ctactacaac 180
cccagcctga agtccagagt gaccatcagc cgggacaaca gcaagaacac cctgtacctg 240
cagatgaaca gcctgagagc cgaggacacc gccatctact actgtgccag agaaggcgtg 300
atgggcggct accacacaga ccccaattac tactactatg gcatggacgt gtggggccag 360
ggcaccacag tgacagtttc ttct                                        384

<210> 160
<211> 376
<212> PRT
<213> Artificial Sequence

<220> 
<223> RJ144 CAR (A7/CD8 TM/4-1BB/CD3zeta)

<400> 160
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly
            20                  25                  30          
Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly
        35                  40                  45              
Phe Thr Phe Ser Asn Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly
    50                  55                  60                  
Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr His Thr Gly Asn Thr Tyr
65                  70                  75                  80  
Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Arg Asp Asn Ser
                85                  90                  95      
Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr
            100                 105                 110         
Ala Ile Tyr Tyr Cys Ala Arg Glu Gly Val Met Gly Gly Tyr His Thr
        115                 120                 125             
Asp Pro Asn Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr
    130                 135                 140                 
Thr Val Thr Val Ser Ser Ala Ala Ala Thr Thr Thr Pro Ala Pro Arg
145                 150                 155                 160 
Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg
                165                 170                 175     
Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly
            180                 185                 190         
Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr
        195                 200                 205             
Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg
    210                 215                 220                 
Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro
225                 230                 235                 240 
Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu
                245                 250                 255     
Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala
            260                 265                 270         
Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu
        275                 280                 285             
Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly
    290                 295                 300                 
Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu
305                 310                 315                 320 
Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser
                325                 330                 335     
Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly
            340                 345                 350         
Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu
        355                 360                 365             
His Met Gln Ala Leu Pro Pro Arg
    370                 375

<210> 161
<211> 1128
<212> DNA
<213> Artificial Sequence

<220> 
<223> RJ144 CAR (A7/CD8 TM/4-1BB/CD3zeta)

<400> 161
atgcttctgc tcgtgacaag cctgctgctg tgcgagctgc cccaccctgc ctttctgctg 60
atccctgagg tgcagctggt tgaatctggc ggaggactgg ttcagcctgg cggatctctg 120
agactgtctt gtgccgccag cggcttcacc ttcagcaact acggcatgag ctgggtccga 180
caggcccctg gaaaaggcct tgagtggatc ggctacatct accacaccgg caacacctac 240
tacaacccca gcctgaagtc cagagtgacc atcagccggg acaacagcaa gaacaccctg 300
tacctgcaga tgaacagcct gagagccgag gacaccgcca tctactactg tgccagagaa 360
ggcgtgatgg gcggctacca cacagacccc aattactact actatggcat ggacgtgtgg 420
ggccagggca ccacagtgac agtttcttct gcggccgcaa ccactactcc ggcacctagg 480
ccccccactc cggcaccgac cattgcatca caaccactga gtcttagacc tgaagcctgt 540
cgacccgcag ctgggggggc agtccacaca cggggattgg atttcgcctg cgatatatac 600
atttgggcgc cactggcagg cacctgcggg gtcctgctct tgtcccttgt catcaccctg 660
tactgtaaga gaggaagaaa gaagttgttg tatattttca aacagccatt catgaggccg 720
gtccagacca ctcaggagga ggatggatgc agttgccgct ttccggaaga ggaagagggt 780
gggtgtgaac tccgagttaa attttctcgc agtgctgatg ccccagcgta taaacagggt 840
cagaaccaac tgtataatga actcaatttg gggaggcgag aggagtatga tgtattggac 900
aagcggcggg ggcgggatcc tgaaatgggc ggtaagccaa ggcgcaagaa tccacaggag 960
ggtttgtata atgagttgca gaaggataaa atggcggaag cgtattcaga aatcggaatg 1020
aagggagagc gccgcagagg gaaagggcat gatggcctct accaaggttt gtcaacagcg 1080
accaaggata cctatgacgc acttcatatg caagcactgc cccccagg              1128

<210> 162
<211> 372
<212> DNA
<213> Artificial Sequence

<220> 
<223> D92 binder

<400> 162
gaggtgcagc tggttgaatc tggcggagga ctggttcagc ctggcggatc tctgagactg 60
agctgtgtgg ccagcggctt cacctttagc agctacggca tgcactgggt ccgacaggca 120
cctggcaaag gcctggaatg gatcggctac agctactaca gcggcagcac ctactacaac 180
cccagcctga agtccctggt caccatcagc agagacaaca gcaagaacac cctgtacctg 240
cagatgaaca gcctgagagc cgaggacacc gccacctact attgtgccag agatggcagc 300
agctggtaca gcttccccta ctactatggc atggacgtgt ggggccaggg caccacagtg 360
acagtttctt ct                                                     372

<210> 163
<211> 372
<212> PRT
<213> Artificial Sequence

<220> 
<223> RJ145 CAR (D92/CD8 TM/4-1BB/CD3zeta)

<400> 163
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly
            20                  25                  30          
Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly
        35                  40                  45              
Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly
    50                  55                  60                  
Lys Gly Leu Glu Trp Ile Gly Tyr Ser Tyr Tyr Ser Gly Ser Thr Tyr
65                  70                  75                  80  
Tyr Asn Pro Ser Leu Lys Ser Leu Val Thr Ile Ser Arg Asp Asn Ser
                85                  90                  95      
Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr
            100                 105                 110         
Ala Thr Tyr Tyr Cys Ala Arg Asp Gly Ser Ser Trp Tyr Ser Phe Pro
        115                 120                 125             
Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val
    130                 135                 140                 
Ser Ser Ala Ala Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro
145                 150                 155                 160 
Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys
                165                 170                 175     
Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala
            180                 185                 190         
Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu
        195                 200                 205             
Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys
    210                 215                 220                 
Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr
225                 230                 235                 240 
Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly
                245                 250                 255     
Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala
            260                 265                 270         
Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg
        275                 280                 285             
Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu
    290                 295                 300                 
Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn
305                 310                 315                 320 
Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met
                325                 330                 335     
Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly
            340                 345                 350         
Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala
        355                 360                 365             
Leu Pro Pro Arg
    370

<210> 164
<211> 1116
<212> DNA
<213> Artificial Sequence

<220> 
<223> RJ145 CAR (D92/CD8 TM/4-1BB/CD3zeta)

<400> 164
atgcttctgc tcgtgacaag cctgctgctg tgcgagctgc cccaccctgc ctttctgctg 60
atccctgagg tgcagctggt tgaatctggc ggaggactgg ttcagcctgg cggatctctg 120
agactgagct gtgtggccag cggcttcacc tttagcagct acggcatgca ctgggtccga 180
caggcacctg gcaaaggcct ggaatggatc ggctacagct actacagcgg cagcacctac 240
tacaacccca gcctgaagtc cctggtcacc atcagcagag acaacagcaa gaacaccctg 300
tacctgcaga tgaacagcct gagagccgag gacaccgcca cctactattg tgccagagat 360
ggcagcagct ggtacagctt cccctactac tatggcatgg acgtgtgggg ccagggcacc 420
acagtgacag tttcttctgc ggccgcaacc actactccgg cacctaggcc ccccactccg 480
gcaccgacca ttgcatcaca accactgagt cttagacctg aagcctgtcg acccgcagct 540
gggggggcag tccacacacg gggattggat ttcgcctgcg atatatacat ttgggcgcca 600
ctggcaggca cctgcggggt cctgctcttg tcccttgtca tcaccctgta ctgtaagaga 660
ggaagaaaga agttgttgta tattttcaaa cagccattca tgaggccggt ccagaccact 720
caggaggagg atggatgcag ttgccgcttt ccggaagagg aagagggtgg gtgtgaactc 780
cgagttaaat tttctcgcag tgctgatgcc ccagcgtata aacagggtca gaaccaactg 840
tataatgaac tcaatttggg gaggcgagag gagtatgatg tattggacaa gcggcggggg 900
cgggatcctg aaatgggcgg taagccaagg cgcaagaatc cacaggaggg tttgtataat 960
gagttgcaga aggataaaat ggcggaagcg tattcagaaa tcggaatgaa gggagagcgc 1020
cgcagaggga aagggcatga tggcctctac caaggtttgt caacagcgac caaggatacc 1080
tatgacgcac ttcatatgca agcactgccc cccagg                           1116

<210> 165
<211> 339
<212> DNA
<213> Artificial Sequence

<220> 
<223> D8 binder

<400> 165
gaggtgcagc tggttgaatc tggcggagga ctggttcagc ctggcggatc tctgagactg 60
tcttgtgccg ccagcggctt caccttcagc aactacggca tgagctgggt ccgacaggcc 120
cctggaaaag ccctggaatg gatcggcgag atcaaccaca gcggcagcac caactacaac 180
cccagcctga agtccagagt gaccatcagc cgggacaaca gcaagaacac cctgtacctg 240
cagatgaaca gcctgagagc cgaggacacc gccatctact actgtagagg cggctgggtc 300
ggatattggg gccagggaac actggtcacc gtgtctagt                        339

<210> 166
<211> 361
<212> PRT
<213> Artificial Sequence

<220> 
<223> RJ146 CAR (D8/CD8 TM/4-1BB/CD3zeta)

<400> 166
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly
            20                  25                  30          
Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly
        35                  40                  45              
Phe Thr Phe Ser Asn Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly
    50                  55                  60                  
Lys Ala Leu Glu Trp Ile Gly Glu Ile Asn His Ser Gly Ser Thr Asn
65                  70                  75                  80  
Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Arg Asp Asn Ser
                85                  90                  95      
Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr
            100                 105                 110         
Ala Ile Tyr Tyr Cys Arg Gly Gly Trp Val Gly Tyr Trp Gly Gln Gly
        115                 120                 125             
Thr Leu Val Thr Val Ser Ser Ala Ala Ala Thr Thr Thr Pro Ala Pro
    130                 135                 140                 
Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu
145                 150                 155                 160 
Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg
                165                 170                 175     
Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly
            180                 185                 190         
Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys
        195                 200                 205             
Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg
    210                 215                 220                 
Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro
225                 230                 235                 240 
Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser
                245                 250                 255     
Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu
            260                 265                 270         
Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg
        275                 280                 285             
Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln
    290                 295                 300                 
Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr
305                 310                 315                 320 
Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp
                325                 330                 335     
Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala
            340                 345                 350         
Leu His Met Gln Ala Leu Pro Pro Arg
        355                 360

<210> 167
<211> 1083
<212> DNA
<213> Artificial Sequence

<220> 
<223> RJ146 CAR (D8/CD8 TM/4-1BB/CD3zeta)

<400> 167
atgcttctgc tcgtgacaag cctgctgctg tgcgagctgc cccaccctgc ctttctgctg 60
atccctgagg tgcagctggt tgaatctggc ggaggactgg ttcagcctgg cggatctctg 120
agactgtctt gtgccgccag cggcttcacc ttcagcaact acggcatgag ctgggtccga 180
caggcccctg gaaaagccct ggaatggatc ggcgagatca accacagcgg cagcaccaac 240
tacaacccca gcctgaagtc cagagtgacc atcagccggg acaacagcaa gaacaccctg 300
tacctgcaga tgaacagcct gagagccgag gacaccgcca tctactactg tagaggcggc 360
tgggtcggat attggggcca gggaacactg gtcaccgtgt ctagtgcggc cgcaaccact 420
actccggcac ctaggccccc cactccggca ccgaccattg catcacaacc actgagtctt 480
agacctgaag cctgtcgacc cgcagctggg ggggcagtcc acacacgggg attggatttc 540
gcctgcgata tatacatttg ggcgccactg gcaggcacct gcggggtcct gctcttgtcc 600
cttgtcatca ccctgtactg taagagagga agaaagaagt tgttgtatat tttcaaacag 660
ccattcatga ggccggtcca gaccactcag gaggaggatg gatgcagttg ccgctttccg 720
gaagaggaag agggtgggtg tgaactccga gttaaatttt ctcgcagtgc tgatgcccca 780
gcgtataaac agggtcagaa ccaactgtat aatgaactca atttggggag gcgagaggag 840
tatgatgtat tggacaagcg gcgggggcgg gatcctgaaa tgggcggtaa gccaaggcgc 900
aagaatccac aggagggttt gtataatgag ttgcagaagg ataaaatggc ggaagcgtat 960
tcagaaatcg gaatgaaggg agagcgccgc agagggaaag ggcatgatgg cctctaccaa 1020
ggtttgtcaa cagcgaccaa ggatacctat gacgcacttc atatgcaagc actgcccccc 1080
agg                                                               1083

<210> 168
<211> 384
<212> DNA
<213> artifiical sequence

<220> 
<223> F11 binder

<400> 168
gaggtgcagc tggttgaatc tggcggagga ctggttcagc ctggcggatc tctgagactg 60
tcttgtgccg ccagcggctt caccttcagc aactacggca tgagctgggt ccgacaggct 120
cctggacaag gcttggagtg ggtgtcctac atcagcaatg gcggcggaac catgtactac 180
gccgacagcg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac 240
ctgcagatga acagcctgag agccgaggac accgccacct actactgtac aagagcccct 300
tactgctctg gcggcgactg ctaccctatg agcacacacg agctggattc ttggggccag 360
ggcacactgg tcacagtgtc atct                                        384

<210> 169
<211> 376
<212> PRT
<213> Artificial Sequence

<220> 
<223> RJ147 CAR (F11/CD8 TM/4-1BB/CD3zeta)

<400> 169
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly
            20                  25                  30          
Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly
        35                  40                  45              
Phe Thr Phe Ser Asn Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly
    50                  55                  60                  
Gln Gly Leu Glu Trp Val Ser Tyr Ile Ser Asn Gly Gly Gly Thr Met
65                  70                  75                  80  
Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
                85                  90                  95      
Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
            100                 105                 110         
Thr Ala Thr Tyr Tyr Cys Thr Arg Ala Pro Tyr Cys Ser Gly Gly Asp
        115                 120                 125             
Cys Tyr Pro Met Ser Thr His Glu Leu Asp Ser Trp Gly Gln Gly Thr
    130                 135                 140                 
Leu Val Thr Val Ser Ser Ala Ala Ala Thr Thr Thr Pro Ala Pro Arg
145                 150                 155                 160 
Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg
                165                 170                 175     
Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly
            180                 185                 190         
Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr
        195                 200                 205             
Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg
    210                 215                 220                 
Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro
225                 230                 235                 240 
Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu
                245                 250                 255     
Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala
            260                 265                 270         
Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu
        275                 280                 285             
Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly
    290                 295                 300                 
Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu
305                 310                 315                 320 
Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser
                325                 330                 335     
Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly
            340                 345                 350         
Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu
        355                 360                 365             
His Met Gln Ala Leu Pro Pro Arg
    370                 375

<210> 170
<211> 1128
<212> DNA
<213> Artificial Sequence

<220> 
<223> RJ147 CAR (F11/CD8 TM/4-1BB/CD3zeta)

<400> 170
atgcttctgc tcgtgacaag cctgctgctg tgcgagctgc cccaccctgc ctttctgctg 60
atccctgagg tgcagctggt tgaatctggc ggaggactgg ttcagcctgg cggatctctg 120
agactgtctt gtgccgccag cggcttcacc ttcagcaact acggcatgag ctgggtccga 180
caggctcctg gacaaggctt ggagtgggtg tcctacatca gcaatggcgg cggaaccatg 240
tactacgccg acagcgtgaa gggcagattc accatcagcc gggacaacag caagaacacc 300
ctgtacctgc agatgaacag cctgagagcc gaggacaccg ccacctacta ctgtacaaga 360
gccccttact gctctggcgg cgactgctac cctatgagca cacacgagct ggattcttgg 420
ggccagggca cactggtcac agtgtcatct gcggccgcaa ccactactcc ggcacctagg 480
ccccccactc cggcaccgac cattgcatca caaccactga gtcttagacc tgaagcctgt 540
cgacccgcag ctgggggggc agtccacaca cggggattgg atttcgcctg cgatatatac 600
atttgggcgc cactggcagg cacctgcggg gtcctgctct tgtcccttgt catcaccctg 660
tactgtaaga gaggaagaaa gaagttgttg tatattttca aacagccatt catgaggccg 720
gtccagacca ctcaggagga ggatggatgc agttgccgct ttccggaaga ggaagagggt 780
gggtgtgaac tccgagttaa attttctcgc agtgctgatg ccccagcgta taaacagggt 840
cagaaccaac tgtataatga actcaatttg gggaggcgag aggagtatga tgtattggac 900
aagcggcggg ggcgggatcc tgaaatgggc ggtaagccaa ggcgcaagaa tccacaggag 960
ggtttgtata atgagttgca gaaggataaa atggcggaag cgtattcaga aatcggaatg 1020
aagggagagc gccgcagagg gaaagggcat gatggcctct accaaggttt gtcaacagcg 1080
accaaggata cctatgacgc acttcatatg caagcactgc cccccagg              1128

<210> 171
<211> 348
<212> DNA
<213> Artificial Sequence

<220> 
<223> C52 binder

<400> 171
gaggtgcagc tggttgaatc tggcggagga ctggttcagc ctggcggatc tctgagactg 60
tcttgtgccg ccagcggctt taccctgagc agctactgga tgagctgggt ccgacaggcc 120
cctggcaaag gactggaatg gatcggcgtg atctactaca gcggcgccac ctactacaac 180
cccagcctga agtctctggt caccatcagc cgggacaaca gcaagaacac cctgtacctg 240
cagatgaaca gcctgagagc cgaggacacc gccgtgtact attgtgctag aggcgccctg 300
gactacttcg acctttgggg acaaggcgcc ctcgtgacag tctcttct              348

<210> 172
<211> 364
<212> PRT
<213> Artificial Sequence

<220> 
<223> RJ148 CAR (C52/CD8 TM/4-1BB/CD3zeta)

<400> 172
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly
            20                  25                  30          
Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly
        35                  40                  45              
Phe Thr Leu Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly
    50                  55                  60                  
Lys Gly Leu Glu Trp Ile Gly Val Ile Tyr Tyr Ser Gly Ala Thr Tyr
65                  70                  75                  80  
Tyr Asn Pro Ser Leu Lys Ser Leu Val Thr Ile Ser Arg Asp Asn Ser
                85                  90                  95      
Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr
            100                 105                 110         
Ala Val Tyr Tyr Cys Ala Arg Gly Ala Leu Asp Tyr Phe Asp Leu Trp
        115                 120                 125             
Gly Gln Gly Ala Leu Val Thr Val Ser Ser Ala Ala Ala Thr Thr Thr
    130                 135                 140                 
Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro
145                 150                 155                 160 
Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val
                165                 170                 175     
His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro
            180                 185                 190         
Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu
        195                 200                 205             
Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro
    210                 215                 220                 
Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys
225                 230                 235                 240 
Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe
                245                 250                 255     
Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu
            260                 265                 270         
Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp
        275                 280                 285             
Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys
    290                 295                 300                 
Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala
305                 310                 315                 320 
Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys
                325                 330                 335     
Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr
            340                 345                 350         
Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
        355                 360

<210> 173
<211> 1092
<212> DNA
<213> Artificial Sequence

<220> 
<223> RJ148 CAR (C52/CD8 TM/4-1BB/CD3zeta)

<400> 173
atgcttctgc tcgtgacaag cctgctgctg tgcgagctgc cccaccctgc ctttctgctg 60
atccctgagg tgcagctggt tgaatctggc ggaggactgg ttcagcctgg cggatctctg 120
agactgtctt gtgccgccag cggctttacc ctgagcagct actggatgag ctgggtccga 180
caggcccctg gcaaaggact ggaatggatc ggcgtgatct actacagcgg cgccacctac 240
tacaacccca gcctgaagtc tctggtcacc atcagccggg acaacagcaa gaacaccctg 300
tacctgcaga tgaacagcct gagagccgag gacaccgccg tgtactattg tgctagaggc 360
gccctggact acttcgacct ttggggacaa ggcgccctcg tgacagtctc ttctgcggcc 420
gcaaccacta ctccggcacc taggcccccc actccggcac cgaccattgc atcacaacca 480
ctgagtctta gacctgaagc ctgtcgaccc gcagctgggg gggcagtcca cacacgggga 540
ttggatttcg cctgcgatat atacatttgg gcgccactgg caggcacctg cggggtcctg 600
ctcttgtccc ttgtcatcac cctgtactgt aagagaggaa gaaagaagtt gttgtatatt 660
ttcaaacagc cattcatgag gccggtccag accactcagg aggaggatgg atgcagttgc 720
cgctttccgg aagaggaaga gggtgggtgt gaactccgag ttaaattttc tcgcagtgct 780
gatgccccag cgtataaaca gggtcagaac caactgtata atgaactcaa tttggggagg 840
cgagaggagt atgatgtatt ggacaagcgg cgggggcggg atcctgaaat gggcggtaag 900
ccaaggcgca agaatccaca ggagggtttg tataatgagt tgcagaagga taaaatggcg 960
gaagcgtatt cagaaatcgg aatgaaggga gagcgccgca gagggaaagg gcatgatggc 1020
ctctaccaag gtttgtcaac agcgaccaag gatacctatg acgcacttca tatgcaagca 1080
ctgcccccca gg                                                     1092

<210> 174
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> H4 L chain

<400> 174
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln Ile Thr His Trp Pro His
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg
            100                 105

<210> 175
<211> 324
<212> DNA
<213> Artificial Sequence

<220> 
<223> H4 L chain

<400> 175
gacatccaga tgacacagag ccctagcagc ctgtctgcca gcgtgggaga cagagtgacc 60
atcacctgta gagccagcca gagcatcagc agctacctga actggtatca gcagaagccc 120
ggcaaggccc ctaaactgct gatctatgcc gccagctctc tgcagtctgg cgtgccatct 180
agattttccg gcagcggctc tggcaccgac ttcaccctga ccatatctag cctgcagcct 240
gaggacgtgg gcgtgtacta ctgcctgcag atcacacact ggccccacac atttggccag 300
ggcaccaagc tggaaatcaa gaga                                        324

<210> 176
<211> 131
<212> PRT
<213> Artificial Sequence

<220> 
<223> H4 H chain

<400> 176
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
            20                  25                  30          
Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Ala Pro Asp Leu Leu Ala Val Pro Thr Val Ile Phe Ser
            100                 105                 110         
Gly Tyr His Tyr Gly Ala Asp Val Trp Gly Gln Gly Ala Thr Val Thr
        115                 120                 125             
Val Ser Ser
    130

<210> 177
<211> 393
<212> DNA
<213> Artificial Sequence

<220> 
<223> H4 H chain

<400> 177
caagttcagc tggttgaatc tggcggcgga ctggttaagc ctggcggttc tctgagactg 60
agctgtgccg cctccggctt caccttcagc gactactaca tgagctggat cagacaggcc 120
cctggcaaag gcctggaatg ggtgtcctac atcagctcca gcggcagcac catctactac 180
gccgatagcg tgaagggcag attcaccatc agccgggaca acgccaagaa cagcctgtac 240
ctgcagatga actccctgag agccgaggac accgccatgt actattgcgc cagagatgcc 300
cctgacctgc tggctgtgcc taccgtgatc tttagcggct accactacgg cgctgacgtt 360
tggggacaag gcgccacagt gacagtgtct agt                              393

<210> 178
<211> 762
<212> DNA
<213> Artificial Sequence

<220> 
<223> H4LH binder

<400> 178
gacatccaga tgacacagag ccctagcagc ctgtctgcca gcgtgggaga cagagtgacc 60
atcacctgta gagccagcca gagcatcagc agctacctga actggtatca gcagaagccc 120
ggcaaggccc ctaaactgct gatctatgcc gccagctctc tgcagtctgg cgtgccatct 180
agattttccg gcagcggctc tggcaccgac ttcaccctga ccatatctag cctgcagcct 240
gaggacgtgg gcgtgtacta ctgcctgcag atcacacact ggccccacac atttggccag 300
ggcaccaagc tggaaatcaa gagaggtggc ggaggatctg gcggaggtgg aagcggcgga 360
ggcggatctc aagttcagct ggttgaatct ggcggcggac tggttaagcc tggcggttct 420
ctgagactga gctgtgccgc ctccggcttc accttcagcg actactacat gagctggatc 480
agacaggccc ctggcaaagg cctggaatgg gtgtcctaca tcagctccag cggcagcacc 540
atctactacg ccgatagcgt gaagggcaga ttcaccatca gccgggacaa cgccaagaac 600
agcctgtacc tgcagatgaa ctccctgaga gccgaggaca ccgccatgta ctattgcgcc 660
agagatgccc ctgacctgct ggctgtgcct accgtgatct ttagcggcta ccactacggc 720
gctgacgttt ggggacaagg cgccacagtg acagtgtcta gt                    762

<210> 179
<211> 762
<212> DNA
<213> Artificial Sequence

<220> 
<223> H4HL binder

<400> 179
caagttcagc tggttgaatc tggcggcgga ctggttaagc ctggcggttc tctgagactg 60
agctgtgccg cctccggctt caccttcagc gactactaca tgagctggat cagacaggcc 120
cctggcaaag gcctggaatg ggtgtcctac atcagctcca gcggcagcac catctactac 180
gccgatagcg tgaagggcag attcaccatc agccgggaca acgccaagaa cagcctgtac 240
ctgcagatga actccctgag agccgaggac accgccatgt actattgcgc cagagatgcc 300
cctgacctgc tggctgtgcc taccgtgatc tttagcggct accactacgg cgctgacgtt 360
tggggacaag gcgccacagt gacagtgtct agtggtggcg gaggatctgg cggaggtgga 420
agcggcggag gcggatctga catccagatg acacagagcc ctagcagcct gtctgccagc 480
gtgggagaca gagtgaccat cacctgtaga gccagccaga gcatcagcag ctacctgaac 540
tggtatcagc agaagcccgg caaggcccct aaactgctga tctatgccgc cagctctctg 600
cagtctggcg tgccatctag attttccggc agcggctctg gcaccgactt caccctgacc 660
atatctagcc tgcagcctga ggacgtgggc gtgtactact gcctgcagat cacacactgg 720
ccccacacat ttggccaggg caccaagctg gaaatcaaga ga                    762

<210> 180
<211> 502
<212> PRT
<213> Artificial Sequence

<220> 
<223> RJ149LH CAR (H4LH/CD8 TM/4-1BB/CD3zeta)

<400> 180
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser
            20                  25                  30          
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
        35                  40                  45              
Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys
    50                  55                  60                  
Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val
65                  70                  75                  80  
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
                85                  90                  95      
Ile Ser Ser Leu Gln Pro Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln
            100                 105                 110         
Ile Thr His Trp Pro His Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile
        115                 120                 125             
Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
    130                 135                 140                 
Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly
145                 150                 155                 160 
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp
                165                 170                 175     
Tyr Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
            180                 185                 190         
Val Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser
        195                 200                 205             
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu
    210                 215                 220                 
Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr
225                 230                 235                 240 
Cys Ala Arg Asp Ala Pro Asp Leu Leu Ala Val Pro Thr Val Ile Phe
                245                 250                 255     
Ser Gly Tyr His Tyr Gly Ala Asp Val Trp Gly Gln Gly Ala Thr Val
            260                 265                 270         
Thr Val Ser Ser Ala Ala Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro
        275                 280                 285             
Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu
    290                 295                 300                 
Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp
305                 310                 315                 320 
Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly
                325                 330                 335     
Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg
            340                 345                 350         
Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln
        355                 360                 365             
Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu
    370                 375                 380                 
Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala
385                 390                 395                 400 
Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu
                405                 410                 415     
Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp
            420                 425                 430         
Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu
        435                 440                 445             
Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile
    450                 455                 460                 
Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr
465                 470                 475                 480 
Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met
                485                 490                 495     
Gln Ala Leu Pro Pro Arg
            500

<210> 181
<211> 1506
<212> DNA
<213> Artificial Sequence

<220> 
<223> RJ149LH CAR (H4LH/CD8 TM/4-1BB/CD3zeta)

<400> 181
atgcttctgc tcgtgacaag cctgctgctg tgcgagctgc cccaccctgc ctttctgctg 60
atccctgaca tccagatgac acagagccct agcagcctgt ctgccagcgt gggagacaga 120
gtgaccatca cctgtagagc cagccagagc atcagcagct acctgaactg gtatcagcag 180
aagcccggca aggcccctaa actgctgatc tatgccgcca gctctctgca gtctggcgtg 240
ccatctagat tttccggcag cggctctggc accgacttca ccctgaccat atctagcctg 300
cagcctgagg acgtgggcgt gtactactgc ctgcagatca cacactggcc ccacacattt 360
ggccagggca ccaagctgga aatcaagaga ggtggcggag gatctggcgg aggtggaagc 420
ggcggaggcg gatctcaagt tcagctggtt gaatctggcg gcggactggt taagcctggc 480
ggttctctga gactgagctg tgccgcctcc ggcttcacct tcagcgacta ctacatgagc 540
tggatcagac aggcccctgg caaaggcctg gaatgggtgt cctacatcag ctccagcggc 600
agcaccatct actacgccga tagcgtgaag ggcagattca ccatcagccg ggacaacgcc 660
aagaacagcc tgtacctgca gatgaactcc ctgagagccg aggacaccgc catgtactat 720
tgcgccagag atgcccctga cctgctggct gtgcctaccg tgatctttag cggctaccac 780
tacggcgctg acgtttgggg acaaggcgcc acagtgacag tgtctagtgc ggccgcaacc 840
actactccgg cacctaggcc ccccactccg gcaccgacca ttgcatcaca accactgagt 900
cttagacctg aagcctgtcg acccgcagct gggggggcag tccacacacg gggattggat 960
ttcgcctgcg atatatacat ttgggcgcca ctggcaggca cctgcggggt cctgctcttg 1020
tcccttgtca tcaccctgta ctgtaagaga ggaagaaaga agttgttgta tattttcaaa 1080
cagccattca tgaggccggt ccagaccact caggaggagg atggatgcag ttgccgcttt 1140
ccggaagagg aagagggtgg gtgtgaactc cgagttaaat tttctcgcag tgctgatgcc 1200
ccagcgtata aacagggtca gaaccaactg tataatgaac tcaatttggg gaggcgagag 1260
gagtatgatg tattggacaa gcggcggggg cgggatcctg aaatgggcgg taagccaagg 1320
cgcaagaatc cacaggaggg tttgtataat gagttgcaga aggataaaat ggcggaagcg 1380
tattcagaaa tcggaatgaa gggagagcgc cgcagaggga aagggcatga tggcctctac 1440
caaggtttgt caacagcgac caaggatacc tatgacgcac ttcatatgca agcactgccc 1500
cccagg                                                            1506

<210> 182
<211> 502
<212> PRT
<213> Artificial Sequence

<220> 
<223> RJ149HL CAR (H4HL/CD8 TM/4-1BB/CD3zeta)

<400> 182
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly
            20                  25                  30          
Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly
        35                  40                  45              
Phe Thr Phe Ser Asp Tyr Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly
    50                  55                  60                  
Lys Gly Leu Glu Trp Val Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile
65                  70                  75                  80  
Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
                85                  90                  95      
Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
            100                 105                 110         
Thr Ala Met Tyr Tyr Cys Ala Arg Asp Ala Pro Asp Leu Leu Ala Val
        115                 120                 125             
Pro Thr Val Ile Phe Ser Gly Tyr His Tyr Gly Ala Asp Val Trp Gly
    130                 135                 140                 
Gln Gly Ala Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
145                 150                 155                 160 
Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro
                165                 170                 175     
Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg
            180                 185                 190         
Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro
        195                 200                 205             
Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser
    210                 215                 220                 
Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
225                 230                 235                 240 
Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Gly Val Tyr Tyr Cys
                245                 250                 255     
Leu Gln Ile Thr His Trp Pro His Thr Phe Gly Gln Gly Thr Lys Leu
            260                 265                 270         
Glu Ile Lys Arg Ala Ala Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro
        275                 280                 285             
Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu
    290                 295                 300                 
Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp
305                 310                 315                 320 
Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly
                325                 330                 335     
Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg
            340                 345                 350         
Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln
        355                 360                 365             
Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu
    370                 375                 380                 
Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala
385                 390                 395                 400 
Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu
                405                 410                 415     
Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp
            420                 425                 430         
Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu
        435                 440                 445             
Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile
    450                 455                 460                 
Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr
465                 470                 475                 480 
Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met
                485                 490                 495     
Gln Ala Leu Pro Pro Arg
            500

<210> 183
<211> 1506
<212> DNA
<213> Artificial Sequence

<220> 
<223> RJ149HL CAR (H4HL/CD8 TM/4-1BB/CD3zeta)

<400> 183
atgcttctgc tcgtgacaag cctgctgctg tgcgagctgc cccaccctgc ctttctgctg 60
atccctcaag ttcagctggt tgaatctggc ggcggactgg ttaagcctgg cggttctctg 120
agactgagct gtgccgcctc cggcttcacc ttcagcgact actacatgag ctggatcaga 180
caggcccctg gcaaaggcct ggaatgggtg tcctacatca gctccagcgg cagcaccatc 240
tactacgccg atagcgtgaa gggcagattc accatcagcc gggacaacgc caagaacagc 300
ctgtacctgc agatgaactc cctgagagcc gaggacaccg ccatgtacta ttgcgccaga 360
gatgcccctg acctgctggc tgtgcctacc gtgatcttta gcggctacca ctacggcgct 420
gacgtttggg gacaaggcgc cacagtgaca gtgtctagtg gtggcggagg atctggcgga 480
ggtggaagcg gcggaggcgg atctgacatc cagatgacac agagccctag cagcctgtct 540
gccagcgtgg gagacagagt gaccatcacc tgtagagcca gccagagcat cagcagctac 600
ctgaactggt atcagcagaa gcccggcaag gcccctaaac tgctgatcta tgccgccagc 660
tctctgcagt ctggcgtgcc atctagattt tccggcagcg gctctggcac cgacttcacc 720
ctgaccatat ctagcctgca gcctgaggac gtgggcgtgt actactgcct gcagatcaca 780
cactggcccc acacatttgg ccagggcacc aagctggaaa tcaagagagc ggccgcaacc 840
actactccgg cacctaggcc ccccactccg gcaccgacca ttgcatcaca accactgagt 900
cttagacctg aagcctgtcg acccgcagct gggggggcag tccacacacg gggattggat 960
ttcgcctgcg atatatacat ttgggcgcca ctggcaggca cctgcggggt cctgctcttg 1020
tcccttgtca tcaccctgta ctgtaagaga ggaagaaaga agttgttgta tattttcaaa 1080
cagccattca tgaggccggt ccagaccact caggaggagg atggatgcag ttgccgcttt 1140
ccggaagagg aagagggtgg gtgtgaactc cgagttaaat tttctcgcag tgctgatgcc 1200
ccagcgtata aacagggtca gaaccaactg tataatgaac tcaatttggg gaggcgagag 1260
gagtatgatg tattggacaa gcggcggggg cgggatcctg aaatgggcgg taagccaagg 1320
cgcaagaatc cacaggaggg tttgtataat gagttgcaga aggataaaat ggcggaagcg 1380
tattcagaaa tcggaatgaa gggagagcgc cgcagaggga aagggcatga tggcctctac 1440
caaggtttgt caacagcgac caaggatacc tatgacgcac ttcatatgca agcactgccc 1500
cccagg                                                            1506

<210> 184
<211> 104
<212> PRT
<213> Artificial Sequence

<220> 
<223> G6 L chain

<400> 184
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Tyr Gly Thr Phe Gly Gln
                85                  90                  95      
Gly Thr Lys Leu Glu Ile Lys Arg
            100

<210> 185
<211> 312
<212> DNA
<213> Artificial Sequence

<220> 
<223> G6 L chain

<400> 185
gacatccaga tgacacagag ccctagcagc ctgtctgcca gcgtgggaga cagagtgacc 60
atcacctgta gagccagcca gagcatcagc agctacctga actggtatca gcagaagccc 120
ggcaaggccc ctaaactgct gatctatgcc gccagctctc tgcagtctgg cgtgccatct 180
agattttccg gcagcggctc tggcaccgac ttcaccctga ccatatctag cctgcagcct 240
gaggatgccg ccacctacta ctgtcagcac tacggcacat ttggccaggg caccaagctg 300
gaaatcaaga ga                                                     312

<210> 186
<211> 127
<212> PRT
<213> Artificial Sequence

<220> 
<223> G6 H chain

<400> 186
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
            20                  25                  30          
Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg His Lys Thr Ser Leu Asn Asp Tyr Asp Phe Trp Ser Gly Tyr
            100                 105                 110         
Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125

<210> 187
<211> 381
<212> DNA
<213> Artificial Sequence

<220> 
<223> G6 H chain

<400> 187
caagttcagc tggttgaatc tggcggcgga ctggttaagc ctggcggttc tctgagactg 60
agctgtgccg cctccggctt caccttcagc gactactaca tgagctggat cagacaggcc 120
cctggcaaag gcctggaatg ggtgtcctac atcagctcca gcggcagcac catctactac 180
gccgatagcg tgaagggcag attcaccatc agccgggaca acgccaagaa cagcctgtac 240
ctgcagatga actccctgag agccgaggac accgccgtgt actattgcgc cagacacaag 300
accagcctga acgactacga cttttggagc ggctacctgc tggactattg gggccaggga 360
acactggtca ccgtgtctag t                                           381

<210> 188
<211> 738
<212> DNA
<213> Artificial Sequence

<220> 
<223> G6LH binder

<400> 188
gacatccaga tgacacagag ccctagcagc ctgtctgcca gcgtgggaga cagagtgacc 60
atcacctgta gagccagcca gagcatcagc agctacctga actggtatca gcagaagccc 120
ggcaaggccc ctaaactgct gatctatgcc gccagctctc tgcagtctgg cgtgccatct 180
agattttccg gcagcggctc tggcaccgac ttcaccctga ccatatctag cctgcagcct 240
gaggatgccg ccacctacta ctgtcagcac tacggcacat ttggccaggg caccaagctg 300
gaaatcaaga gaggtggcgg aggatctggc ggaggtggaa gcggcggagg cggatctcaa 360
gttcagctgg ttgaatctgg cggcggactg gttaagcctg gcggttctct gagactgagc 420
tgtgccgcct ccggcttcac cttcagcgac tactacatga gctggatcag acaggcccct 480
ggcaaaggcc tggaatgggt gtcctacatc agctccagcg gcagcaccat ctactacgcc 540
gatagcgtga agggcagatt caccatcagc cgggacaacg ccaagaacag cctgtacctg 600
cagatgaact ccctgagagc cgaggacacc gccgtgtact attgcgccag acacaagacc 660
agcctgaacg actacgactt ttggagcggc tacctgctgg actattgggg ccagggaaca 720
ctggtcaccg tgtctagt                                               738

<210> 189
<211> 738
<212> DNA
<213> Artificial Sequence

<220> 
<223> G6HL binder

<400> 189
caagttcagc tggttgaatc tggcggcgga ctggttaagc ctggcggttc tctgagactg 60
agctgtgccg cctccggctt caccttcagc gactactaca tgagctggat cagacaggcc 120
cctggcaaag gcctggaatg ggtgtcctac atcagctcca gcggcagcac catctactac 180
gccgatagcg tgaagggcag attcaccatc agccgggaca acgccaagaa cagcctgtac 240
ctgcagatga actccctgag agccgaggac accgccgtgt actattgcgc cagacacaag 300
accagcctga acgactacga cttttggagc ggctacctgc tggactattg gggccaggga 360
acactggtca ccgtgtctag tggtggcgga ggatctggcg gaggtggaag cggcggaggc 420
ggatctgaca tccagatgac acagagccct agcagcctgt ctgccagcgt gggagacaga 480
gtgaccatca cctgtagagc cagccagagc atcagcagct acctgaactg gtatcagcag 540
aagcccggca aggcccctaa actgctgatc tatgccgcca gctctctgca gtctggcgtg 600
ccatctagat tttccggcag cggctctggc accgacttca ccctgaccat atctagcctg 660
cagcctgagg atgccgccac ctactactgt cagcactacg gcacatttgg ccagggcacc 720
aagctggaaa tcaagaga                                               738

<210> 190
<211> 494
<212> PRT
<213> Artificial Sequence

<220> 
<223> RJ150LH CAR (G6LH/CD8 TM/4-1BB/CD3zeta)

<400> 190
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser
            20                  25                  30          
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
        35                  40                  45              
Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys
    50                  55                  60                  
Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val
65                  70                  75                  80  
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
                85                  90                  95      
Ile Ser Ser Leu Gln Pro Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His
            100                 105                 110         
Tyr Gly Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln
    130                 135                 140                 
Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg
145                 150                 155                 160 
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr Tyr Met Ser
                165                 170                 175     
Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Tyr Ile
            180                 185                 190         
Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg
        195                 200                 205             
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met
    210                 215                 220                 
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg His
225                 230                 235                 240 
Lys Thr Ser Leu Asn Asp Tyr Asp Phe Trp Ser Gly Tyr Leu Leu Asp
                245                 250                 255     
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Thr
            260                 265                 270         
Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser
        275                 280                 285             
Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly
    290                 295                 300                 
Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp
305                 310                 315                 320 
Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile
                325                 330                 335     
Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys
            340                 345                 350         
Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys
        355                 360                 365             
Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val
    370                 375                 380                 
Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn
385                 390                 395                 400 
Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val
                405                 410                 415     
Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg
            420                 425                 430         
Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys
        435                 440                 445             
Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg
    450                 455                 460                 
Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys
465                 470                 475                 480 
Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
                485                 490

<210> 191
<211> 1482
<212> DNA
<213> Artificial Sequence

<220> 
<223> RJ150LH CAR (G6LH/CD8 TM/4-1BB/CD3zeta)

<400> 191
atgcttctgc tcgtgacaag cctgctgctg tgcgagctgc cccaccctgc ctttctgctg 60
atccctgaca tccagatgac acagagccct agcagcctgt ctgccagcgt gggagacaga 120
gtgaccatca cctgtagagc cagccagagc atcagcagct acctgaactg gtatcagcag 180
aagcccggca aggcccctaa actgctgatc tatgccgcca gctctctgca gtctggcgtg 240
ccatctagat tttccggcag cggctctggc accgacttca ccctgaccat atctagcctg 300
cagcctgagg atgccgccac ctactactgt cagcactacg gcacatttgg ccagggcacc 360
aagctggaaa tcaagagagg tggcggagga tctggcggag gtggaagcgg cggaggcgga 420
tctcaagttc agctggttga atctggcggc ggactggtta agcctggcgg ttctctgaga 480
ctgagctgtg ccgcctccgg cttcaccttc agcgactact acatgagctg gatcagacag 540
gcccctggca aaggcctgga atgggtgtcc tacatcagct ccagcggcag caccatctac 600
tacgccgata gcgtgaaggg cagattcacc atcagccggg acaacgccaa gaacagcctg 660
tacctgcaga tgaactccct gagagccgag gacaccgccg tgtactattg cgccagacac 720
aagaccagcc tgaacgacta cgacttttgg agcggctacc tgctggacta ttggggccag 780
ggaacactgg tcaccgtgtc tagtgcggcc gcaaccacta ctccggcacc taggcccccc 840
actccggcac cgaccattgc atcacaacca ctgagtctta gacctgaagc ctgtcgaccc 900
gcagctgggg gggcagtcca cacacgggga ttggatttcg cctgcgatat atacatttgg 960
gcgccactgg caggcacctg cggggtcctg ctcttgtccc ttgtcatcac cctgtactgt 1020
aagagaggaa gaaagaagtt gttgtatatt ttcaaacagc cattcatgag gccggtccag 1080
accactcagg aggaggatgg atgcagttgc cgctttccgg aagaggaaga gggtgggtgt 1140
gaactccgag ttaaattttc tcgcagtgct gatgccccag cgtataaaca gggtcagaac 1200
caactgtata atgaactcaa tttggggagg cgagaggagt atgatgtatt ggacaagcgg 1260
cgggggcggg atcctgaaat gggcggtaag ccaaggcgca agaatccaca ggagggtttg 1320
tataatgagt tgcagaagga taaaatggcg gaagcgtatt cagaaatcgg aatgaaggga 1380
gagcgccgca gagggaaagg gcatgatggc ctctaccaag gtttgtcaac agcgaccaag 1440
gatacctatg acgcacttca tatgcaagca ctgcccccca gg                    1482

<210> 192
<211> 494
<212> PRT
<213> Artificial Sequence

<220> 
<223> RJ150HL CAR (G6HL/CD8 TM/4-1BB/CD3zeta)

<400> 192
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly
            20                  25                  30          
Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly
        35                  40                  45              
Phe Thr Phe Ser Asp Tyr Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly
    50                  55                  60                  
Lys Gly Leu Glu Trp Val Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile
65                  70                  75                  80  
Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
                85                  90                  95      
Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
            100                 105                 110         
Thr Ala Val Tyr Tyr Cys Ala Arg His Lys Thr Ser Leu Asn Asp Tyr
        115                 120                 125             
Asp Phe Trp Ser Gly Tyr Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu
    130                 135                 140                 
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
145                 150                 155                 160 
Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser
                165                 170                 175     
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser
            180                 185                 190         
Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro
        195                 200                 205             
Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser
    210                 215                 220                 
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
225                 230                 235                 240 
Ser Leu Gln Pro Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Tyr Gly
                245                 250                 255     
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Thr
            260                 265                 270         
Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser
        275                 280                 285             
Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly
    290                 295                 300                 
Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp
305                 310                 315                 320 
Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile
                325                 330                 335     
Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys
            340                 345                 350         
Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys
        355                 360                 365             
Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val
    370                 375                 380                 
Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn
385                 390                 395                 400 
Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val
                405                 410                 415     
Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg
            420                 425                 430         
Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys
        435                 440                 445             
Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg
    450                 455                 460                 
Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys
465                 470                 475                 480 
Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
                485                 490

<210> 193
<211> 1482
<212> DNA
<213> Artificial Sequence

<220> 
<223> RJ150HL CAR (G6HL/CD8 TM/4-1BB/CD3zeta)

<400> 193
atgcttctgc tcgtgacaag cctgctgctg tgcgagctgc cccaccctgc ctttctgctg 60
atccctcaag ttcagctggt tgaatctggc ggcggactgg ttaagcctgg cggttctctg 120
agactgagct gtgccgcctc cggcttcacc ttcagcgact actacatgag ctggatcaga 180
caggcccctg gcaaaggcct ggaatgggtg tcctacatca gctccagcgg cagcaccatc 240
tactacgccg atagcgtgaa gggcagattc accatcagcc gggacaacgc caagaacagc 300
ctgtacctgc agatgaactc cctgagagcc gaggacaccg ccgtgtacta ttgcgccaga 360
cacaagacca gcctgaacga ctacgacttt tggagcggct acctgctgga ctattggggc 420
cagggaacac tggtcaccgt gtctagtggt ggcggaggat ctggcggagg tggaagcggc 480
ggaggcggat ctgacatcca gatgacacag agccctagca gcctgtctgc cagcgtggga 540
gacagagtga ccatcacctg tagagccagc cagagcatca gcagctacct gaactggtat 600
cagcagaagc ccggcaaggc ccctaaactg ctgatctatg ccgccagctc tctgcagtct 660
ggcgtgccat ctagattttc cggcagcggc tctggcaccg acttcaccct gaccatatct 720
agcctgcagc ctgaggatgc cgccacctac tactgtcagc actacggcac atttggccag 780
ggcaccaagc tggaaatcaa gagagcggcc gcaaccacta ctccggcacc taggcccccc 840
actccggcac cgaccattgc atcacaacca ctgagtctta gacctgaagc ctgtcgaccc 900
gcagctgggg gggcagtcca cacacgggga ttggatttcg cctgcgatat atacatttgg 960
gcgccactgg caggcacctg cggggtcctg ctcttgtccc ttgtcatcac cctgtactgt 1020
aagagaggaa gaaagaagtt gttgtatatt ttcaaacagc cattcatgag gccggtccag 1080
accactcagg aggaggatgg atgcagttgc cgctttccgg aagaggaaga gggtgggtgt 1140
gaactccgag ttaaattttc tcgcagtgct gatgccccag cgtataaaca gggtcagaac 1200
caactgtata atgaactcaa tttggggagg cgagaggagt atgatgtatt ggacaagcgg 1260
cgggggcggg atcctgaaat gggcggtaag ccaaggcgca agaatccaca ggagggtttg 1320
tataatgagt tgcagaagga taaaatggcg gaagcgtatt cagaaatcgg aatgaaggga 1380
gagcgccgca gagggaaagg gcatgatggc ctctaccaag gtttgtcaac agcgaccaag 1440
gatacctatg acgcacttca tatgcaagca ctgcccccca gg                    1482

<210> 194
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> C9 L chain

<400> 194
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg
            100                 105

<210> 195
<211> 324
<212> DNA
<213> Artificial Sequence

<220> 
<223> C9 L chain

<400> 195
gacatccaga tgacacagag ccctagcagc ctgtctgcca gcgtgggaga cagagtgacc 60
atcacctgta gagccagcca gagcatcagc agctacctga actggtatca gcagaagccc 120
ggcaaggccc ctaaactgct gatctatgcc gccagctctc tgcagtctgg cgtgccatct 180
agattttccg gcagcggctc tggcaccgac ttcaccctga ccatatctag cctgcagcct 240
gaggacttcg ccgtgtacta ctgccagcag agaagcaact ggcctcctac ctttggccag 300
ggcaccaagc tggaaatcaa gaga                                        324

<210> 196
<211> 125
<212> PRT
<213> Artificial Sequence

<220> 
<223> C9 H chain

<400> 196
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
            20                  25                  30          
Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Lys Tyr Tyr Cys
                85                  90                  95      
Ala Thr Ala Val Phe Ser Leu Gly Pro Glu Gly Tyr Tyr Tyr Tyr Met
            100                 105                 110         
Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser
        115                 120                 125

<210> 197
<211> 375
<212> DNA
<213> Artificial Sequence

<220> 
<223> C9 H chain

<400> 197
caagttcagc tggttgaatc tggcggcgga ctggttaagc ctggcggttc tctgagactg 60
agctgtgccg cctccggctt caccttcagc gactactaca tgagctggat cagacaggcc 120
cctggcaaag gcctggaatg ggtgtcctac atcagctcca gcggcagcac catctactac 180
gccgatagcg tgaagggcag attcaccatc agccgggaca acgccaagaa cagcctgtac 240
ctgcagatga actccctgag agccgaggat accgccaagt actactgtgc caccgccgtg 300
ttttctctgg gccctgaggg ctactactac tatatggacg tgtggggcaa gggcaccacc 360
gtgacagttt cttct                                                  375

<210> 198
<211> 744
<212> DNA
<213> Artificial Sequence

<220> 
<223> C9LH binder

<400> 198
gacatccaga tgacacagag ccctagcagc ctgtctgcca gcgtgggaga cagagtgacc 60
atcacctgta gagccagcca gagcatcagc agctacctga actggtatca gcagaagccc 120
ggcaaggccc ctaaactgct gatctatgcc gccagctctc tgcagtctgg cgtgccatct 180
agattttccg gcagcggctc tggcaccgac ttcaccctga ccatatctag cctgcagcct 240
gaggacttcg ccgtgtacta ctgccagcag agaagcaact ggcctcctac ctttggccag 300
ggcaccaagc tggaaatcaa gagaggtggc ggaggatctg gcggaggtgg aagcggcgga 360
ggcggatctc aagttcagct ggttgaatct ggcggcggac tggttaagcc tggcggttct 420
ctgagactga gctgtgccgc ctccggcttc accttcagcg actactacat gagctggatc 480
agacaggccc ctggcaaagg cctggaatgg gtgtcctaca tcagctccag cggcagcacc 540
atctactacg ccgatagcgt gaagggcaga ttcaccatca gccgggacaa cgccaagaac 600
agcctgtacc tgcagatgaa ctccctgaga gccgaggata ccgccaagta ctactgtgcc 660
accgccgtgt tttctctggg ccctgagggc tactactact atatggacgt gtggggcaag 720
ggcaccaccg tgacagtttc ttct                                        744

<210> 199
<211> 744
<212> PRT
<213> Artificial Sequence

<220> 
<223> C9HL binder

<400> 199
Cys Ala Ala Gly Thr Thr Cys Ala Gly Cys Thr Gly Gly Thr Thr Gly
 1               5                  10                  15      
Ala Ala Thr Cys Thr Gly Gly Cys Gly Gly Cys Gly Gly Ala Cys Thr
            20                  25                  30          
Gly Gly Thr Thr Ala Ala Gly Cys Cys Thr Gly Gly Cys Gly Gly Thr
        35                  40                  45              
Thr Cys Thr Cys Thr Gly Ala Gly Ala Cys Thr Gly Ala Gly Cys Thr
    50                  55                  60                  
Gly Thr Gly Cys Cys Gly Cys Cys Thr Cys Cys Gly Gly Cys Thr Thr
65                  70                  75                  80  
Cys Ala Cys Cys Thr Thr Cys Ala Gly Cys Gly Ala Cys Thr Ala Cys
                85                  90                  95      
Thr Ala Cys Ala Thr Gly Ala Gly Cys Thr Gly Gly Ala Thr Cys Ala
            100                 105                 110         
Gly Ala Cys Ala Gly Gly Cys Cys Cys Cys Thr Gly Gly Cys Ala Ala
        115                 120                 125             
Ala Gly Gly Cys Cys Thr Gly Gly Ala Ala Thr Gly Gly Gly Thr Gly
    130                 135                 140                 
Thr Cys Cys Thr Ala Cys Ala Thr Cys Ala Gly Cys Thr Cys Cys Ala
145                 150                 155                 160 
Gly Cys Gly Gly Cys Ala Gly Cys Ala Cys Cys Ala Thr Cys Thr Ala
                165                 170                 175     
Cys Thr Ala Cys Gly Cys Cys Gly Ala Thr Ala Gly Cys Gly Thr Gly
            180                 185                 190         
Ala Ala Gly Gly Gly Cys Ala Gly Ala Thr Thr Cys Ala Cys Cys Ala
        195                 200                 205             
Thr Cys Ala Gly Cys Cys Gly Gly Gly Ala Cys Ala Ala Cys Gly Cys
    210                 215                 220                 
Cys Ala Ala Gly Ala Ala Cys Ala Gly Cys Cys Thr Gly Thr Ala Cys
225                 230                 235                 240 
Cys Thr Gly Cys Ala Gly Ala Thr Gly Ala Ala Cys Thr Cys Cys Cys
                245                 250                 255     
Thr Gly Ala Gly Ala Gly Cys Cys Gly Ala Gly Gly Ala Thr Ala Cys
            260                 265                 270         
Cys Gly Cys Cys Ala Ala Gly Thr Ala Cys Thr Ala Cys Thr Gly Thr
        275                 280                 285             
Gly Cys Cys Ala Cys Cys Gly Cys Cys Gly Thr Gly Thr Thr Thr Thr
    290                 295                 300                 
Cys Thr Cys Thr Gly Gly Gly Cys Cys Cys Thr Gly Ala Gly Gly Gly
305                 310                 315                 320 
Cys Thr Ala Cys Thr Ala Cys Thr Ala Cys Thr Ala Thr Ala Thr Gly
                325                 330                 335     
Gly Ala Cys Gly Thr Gly Thr Gly Gly Gly Gly Cys Ala Ala Gly Gly
            340                 345                 350         
Gly Cys Ala Cys Cys Ala Cys Cys Gly Thr Gly Ala Cys Ala Gly Thr
        355                 360                 365             
Thr Thr Cys Thr Thr Cys Thr Gly Gly Thr Gly Gly Cys Gly Gly Ala
    370                 375                 380                 
Gly Gly Ala Thr Cys Thr Gly Gly Cys Gly Gly Ala Gly Gly Thr Gly
385                 390                 395                 400 
Gly Ala Ala Gly Cys Gly Gly Cys Gly Gly Ala Gly Gly Cys Gly Gly
                405                 410                 415     
Ala Thr Cys Thr Gly Ala Cys Ala Thr Cys Cys Ala Gly Ala Thr Gly
            420                 425                 430         
Ala Cys Ala Cys Ala Gly Ala Gly Cys Cys Cys Thr Ala Gly Cys Ala
        435                 440                 445             
Gly Cys Cys Thr Gly Thr Cys Thr Gly Cys Cys Ala Gly Cys Gly Thr
    450                 455                 460                 
Gly Gly Gly Ala Gly Ala Cys Ala Gly Ala Gly Thr Gly Ala Cys Cys
465                 470                 475                 480 
Ala Thr Cys Ala Cys Cys Thr Gly Thr Ala Gly Ala Gly Cys Cys Ala
                485                 490                 495     
Gly Cys Cys Ala Gly Ala Gly Cys Ala Thr Cys Ala Gly Cys Ala Gly
            500                 505                 510         
Cys Thr Ala Cys Cys Thr Gly Ala Ala Cys Thr Gly Gly Thr Ala Thr
        515                 520                 525             
Cys Ala Gly Cys Ala Gly Ala Ala Gly Cys Cys Cys Gly Gly Cys Ala
    530                 535                 540                 
Ala Gly Gly Cys Cys Cys Cys Thr Ala Ala Ala Cys Thr Gly Cys Thr
545                 550                 555                 560 
Gly Ala Thr Cys Thr Ala Thr Gly Cys Cys Gly Cys Cys Ala Gly Cys
                565                 570                 575     
Thr Cys Thr Cys Thr Gly Cys Ala Gly Thr Cys Thr Gly Gly Cys Gly
            580                 585                 590         
Thr Gly Cys Cys Ala Thr Cys Thr Ala Gly Ala Thr Thr Thr Thr Cys
        595                 600                 605             
Cys Gly Gly Cys Ala Gly Cys Gly Gly Cys Thr Cys Thr Gly Gly Cys
    610                 615                 620                 
Ala Cys Cys Gly Ala Cys Thr Thr Cys Ala Cys Cys Cys Thr Gly Ala
625                 630                 635                 640 
Cys Cys Ala Thr Ala Thr Cys Thr Ala Gly Cys Cys Thr Gly Cys Ala
                645                 650                 655     
Gly Cys Cys Thr Gly Ala Gly Gly Ala Cys Thr Thr Cys Gly Cys Cys
            660                 665                 670         
Gly Thr Gly Thr Ala Cys Thr Ala Cys Thr Gly Cys Cys Ala Gly Cys
        675                 680                 685             
Ala Gly Ala Gly Ala Ala Gly Cys Ala Ala Cys Thr Gly Gly Cys Cys
    690                 695                 700                 
Thr Cys Cys Thr Ala Cys Cys Thr Thr Thr Gly Gly Cys Cys Ala Gly
705                 710                 715                 720 
Gly Gly Cys Ala Cys Cys Ala Ala Gly Cys Thr Gly Gly Ala Ala Ala
                725                 730                 735     
Thr Cys Ala Ala Gly Ala Gly Ala
            740

<210> 200
<211> 496
<212> PRT
<213> Artificial Sequence

<220> 
<223> RJ151LH CAR (C9LH/CD8 TM/4-1BB/CD3zeta)

<400> 200
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser
            20                  25                  30          
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
        35                  40                  45              
Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys
    50                  55                  60                  
Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val
65                  70                  75                  80  
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
                85                  90                  95      
Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln
            100                 105                 110         
Arg Ser Asn Trp Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile
        115                 120                 125             
Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
    130                 135                 140                 
Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly
145                 150                 155                 160 
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp
                165                 170                 175     
Tyr Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
            180                 185                 190         
Val Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser
        195                 200                 205             
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu
    210                 215                 220                 
Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Lys Tyr Tyr
225                 230                 235                 240 
Cys Ala Thr Ala Val Phe Ser Leu Gly Pro Glu Gly Tyr Tyr Tyr Tyr
                245                 250                 255     
Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Ala Ala
            260                 265                 270         
Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile
        275                 280                 285             
Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala
    290                 295                 300                 
Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr
305                 310                 315                 320 
Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu
                325                 330                 335     
Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile
            340                 345                 350         
Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp
        355                 360                 365             
Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu
    370                 375                 380                 
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly
385                 390                 395                 400 
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr
                405                 410                 415     
Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys
            420                 425                 430         
Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys
        435                 440                 445             
Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg
    450                 455                 460                 
Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala
465                 470                 475                 480 
Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
                485                 490                 495

<210> 201
<211> 1489
<212> DNA
<213> Artificial Sequence

<220> 
<223> RJ151LH CAR (C9LH/CD8 TM/4-1BB/CD3zeta)

<400> 201
atgcttctgc tcgtgacaag cctgctgctg tgcgagctgc cccaccctgc ctttctgctg 60
atccctgaca tccagatgac acagagccct agcagcctgt ctgccagcgt gggagacaga 120
gtgaccatca cctgtagagc cagccagagc atcagcagct acctgaactg gtatcagcag 180
aagcccggca aggcccctaa actgctgatc tatgccgcca gctctctgca gtctggcgtg 240
ccatctagat tttccggcag cggctctggc accgacttca ccctgaccat atctagcctg 300
cagcctgagg acttcgccgt gtactactgc cagcagagaa gcaactggcc tcctaccttt 360
ggccagggca ccaagctgga aatcaagaga ggtggcggag gatctggcgg aggtggaagc 420
ggcggaggcg gatctcaagt tcagctggtt gaatctggcg gcggactggt taagcctggc 480
ggttctctga gactgagctg tgccgcctcc ggcttcacct tcagcgacta ctacatgagc 540
tggatcagac aggcccctgg caaaggcctg gaatgggtgt cctacatcag ctccagcggc 600
agcaccatct actacgccga tagcgtgaag ggcagattca ccatcagccg ggacaacgcc 660
aagaacagcc tgtacctgca gatgaactcc ctgagagccg aggataccgc caagtactac 720
tgtgccaccg ccgtgttttc tctgggccct gagggctact actactatat ggacgtgtgg 780
ggcaagggca ccaccgtgac agtttcttct gcggccgcaa ccactactcc ggcacctagg 840
ccccccactc cggcaccgac cattgcatca caaccactga gtcttagacc tgaagcctgt 900
cgacccgcag ctgggggggc agtccacaca cggggattgg atttcgcctg cgatatatac 960
atttgggcgc cactggcagg cacctgcggg gtcctgctct tgtcccttgt catcaccctg 1020
tactgtaaga gaggaagaaa gaagttgttg tatattttca aacagccatt catgaggccg 1080
gtccagacca ctcaggagga ggatggatgc agttgccgct ttccggaaga ggaagagggt 1140
gggtgtgaac tccgagttaa attttctcgc agtgctgatg ccccagcgta taaacagggt 1200
cagaaccaac tgtataatga actcaatttg gggaggcgag aggagtatga tgtattggac 1260
aagcggcggg ggcgggatcc tgaaatgggc ggtaagccaa ggcgcaagaa tccacaggag 1320
ggtttgtata atgagttgca gaaggataaa atggcggaag cgtattcaga aatcggaatg 1380
aagggagagc gccgcagagg gaaagggcat gatggcctct accaaggttt gtcaacagcg 1440
accaaggata cctatgacgc acttcatatg caagcactgc cccccaggt             1489

<210> 202
<211> 496
<212> PRT
<213> Artificial Sequence

<220> 
<223> RJ151HL CAR (C9HL/CD8 TM/4-1BB/CD3zeta)

<400> 202
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly
            20                  25                  30          
Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly
        35                  40                  45              
Phe Thr Phe Ser Asp Tyr Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly
    50                  55                  60                  
Lys Gly Leu Glu Trp Val Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile
65                  70                  75                  80  
Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
                85                  90                  95      
Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
            100                 105                 110         
Thr Ala Lys Tyr Tyr Cys Ala Thr Ala Val Phe Ser Leu Gly Pro Glu
        115                 120                 125             
Gly Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr
    130                 135                 140                 
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
145                 150                 155                 160 
Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser
                165                 170                 175     
Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser
            180                 185                 190         
Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu
        195                 200                 205             
Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe
    210                 215                 220                 
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu
225                 230                 235                 240 
Gln Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp
                245                 250                 255     
Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala
            260                 265                 270         
Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile
        275                 280                 285             
Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala
    290                 295                 300                 
Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr
305                 310                 315                 320 
Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu
                325                 330                 335     
Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile
            340                 345                 350         
Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp
        355                 360                 365             
Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu
    370                 375                 380                 
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly
385                 390                 395                 400 
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr
                405                 410                 415     
Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys
            420                 425                 430         
Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys
        435                 440                 445             
Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg
    450                 455                 460                 
Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala
465                 470                 475                 480 
Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
                485                 490                 495

<210> 203
<211> 1488
<212> DNA
<213> Artificial Sequence

<220> 
<223> RJ151HL CAR (C9HL/CD8 TM/4-1BB/CD3zeta)

<400> 203
atgcttctgc tcgtgacaag cctgctgctg tgcgagctgc cccaccctgc ctttctgctg 60
atccctcaag ttcagctggt tgaatctggc ggcggactgg ttaagcctgg cggttctctg 120
agactgagct gtgccgcctc cggcttcacc ttcagcgact actacatgag ctggatcaga 180
caggcccctg gcaaaggcct ggaatgggtg tcctacatca gctccagcgg cagcaccatc 240
tactacgccg atagcgtgaa gggcagattc accatcagcc gggacaacgc caagaacagc 300
ctgtacctgc agatgaactc cctgagagcc gaggataccg ccaagtacta ctgtgccacc 360
gccgtgtttt ctctgggccc tgagggctac tactactata tggacgtgtg gggcaagggc 420
accaccgtga cagtttcttc tggtggcgga ggatctggcg gaggtggaag cggcggaggc 480
ggatctgaca tccagatgac acagagccct agcagcctgt ctgccagcgt gggagacaga 540
gtgaccatca cctgtagagc cagccagagc atcagcagct acctgaactg gtatcagcag 600
aagcccggca aggcccctaa actgctgatc tatgccgcca gctctctgca gtctggcgtg 660
ccatctagat tttccggcag cggctctggc accgacttca ccctgaccat atctagcctg 720
cagcctgagg acttcgccgt gtactactgc cagcagagaa gcaactggcc tcctaccttt 780
ggccagggca ccaagctgga aatcaagaga gcggccgcaa ccactactcc ggcacctagg 840
ccccccactc cggcaccgac cattgcatca caaccactga gtcttagacc tgaagcctgt 900
cgacccgcag ctgggggggc agtccacaca cggggattgg atttcgcctg cgatatatac 960
atttgggcgc cactggcagg cacctgcggg gtcctgctct tgtcccttgt catcaccctg 1020
tactgtaaga gaggaagaaa gaagttgttg tatattttca aacagccatt catgaggccg 1080
gtccagacca ctcaggagga ggatggatgc agttgccgct ttccggaaga ggaagagggt 1140
gggtgtgaac tccgagttaa attttctcgc agtgctgatg ccccagcgta taaacagggt 1200
cagaaccaac tgtataatga actcaatttg gggaggcgag aggagtatga tgtattggac 1260
aagcggcggg ggcgggatcc tgaaatgggc ggtaagccaa ggcgcaagaa tccacaggag 1320
ggtttgtata atgagttgca gaaggataaa atggcggaag cgtattcaga aatcggaatg 1380
aagggagagc gccgcagagg gaaagggcat gatggcctct accaaggttt gtcaacagcg 1440
accaaggata cctatgacgc acttcatatg caagcactgc cccccagg              1488

<210> 204
<211> 104
<212> PRT
<213> Artificial Sequence

<220> 
<223> D7 L chain

<400> 204
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Ile Ala Ala Tyr Tyr Cys Gln His Tyr Gly Thr Phe Gly Gln
                85                  90                  95      
Gly Thr Lys Leu Glu Ile Lys Arg
            100

<210> 205
<211> 312
<212> DNA
<213> Artificial Sequence

<220> 
<223> D7 L chain

<400> 205
gacatccaga tgacacagag ccctagcagc ctgtctgcca gcgtgggaga cagagtgacc 60
atcacctgta gagccagcca gagcatcagc agctacctga actggtatca gcagaagccc 120
ggcaaggccc ctaaactgct gatctatgcc gccagctctc tgcagtctgg cgtgccatct 180
agattttccg gcagcggctc tggcaccgac ttcaccctga ccatatctag cctgcagcct 240
gaggatatcg ccgcctacta ctgtcagcac tacggcacat ttggccaggg caccaagctg 300
gaaatcaaga ga                                                     312

<210> 206
<211> 128
<212> PRT
<213> Artificial Sequence

<220> 
<223> D7 H chain

<400> 206
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
            20                  25                  30          
Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Gly Tyr Pro Leu Gly Gly Gly Tyr Asp Phe Trp Ser Gly
            100                 105                 110         
Tyr Tyr Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125

<210> 207
<211> 384
<212> DNA
<213> Artificial Sequence

<220> 
<223> D7 H chain

<400> 207
caagttcagc tggttgaatc tggcggcgga ctggttaagc ctggcggttc tctgagactg 60
agctgtgccg cctccggctt caccttcagc gactactaca tgagctggat cagacaggcc 120
cctggcaaag gcctggaatg ggtgtcctac atcagctcca gcggcagcac catctactac 180
gccgatagcg tgaagggcag attcaccatc agccgggaca acgccaagaa cagcctgtac 240
ctgcagatga actccctgag agccgaggac accgccgtgt actactgtgc cagagatggc 300
tatcctcttg gcggaggcta cgacttttgg agcggctact accccgatta ctggggccag 360
ggaacactgg tcacagtgtc tagt                                        384

<210> 208
<211> 741
<212> DNA
<213> Artificial Sequence

<220> 
<223> D7LH binder

<400> 208
gacatccaga tgacacagag ccctagcagc ctgtctgcca gcgtgggaga cagagtgacc 60
atcacctgta gagccagcca gagcatcagc agctacctga actggtatca gcagaagccc 120
ggcaaggccc ctaaactgct gatctatgcc gccagctctc tgcagtctgg cgtgccatct 180
agattttccg gcagcggctc tggcaccgac ttcaccctga ccatatctag cctgcagcct 240
gaggatatcg ccgcctacta ctgtcagcac tacggcacat ttggccaggg caccaagctg 300
gaaatcaaga gaggtggcgg aggatctggc ggaggtggaa gcggcggagg cggatctcaa 360
gttcagctgg ttgaatctgg cggcggactg gttaagcctg gcggttctct gagactgagc 420
tgtgccgcct ccggcttcac cttcagcgac tactacatga gctggatcag acaggcccct 480
ggcaaaggcc tggaatgggt gtcctacatc agctccagcg gcagcaccat ctactacgcc 540
gatagcgtga agggcagatt caccatcagc cgggacaacg ccaagaacag cctgtacctg 600
cagatgaact ccctgagagc cgaggacacc gccgtgtact actgtgccag agatggctat 660
cctcttggcg gaggctacga cttttggagc ggctactacc ccgattactg gggccaggga 720
acactggtca cagtgtctag t                                           741

<210> 209
<211> 741
<212> DNA
<213> Artificial Sequence

<220> 
<223> D7HL binder

<400> 209
caagttcagc tggttgaatc tggcggcgga ctggttaagc ctggcggttc tctgagactg 60
agctgtgccg cctccggctt caccttcagc gactactaca tgagctggat cagacaggcc 120
cctggcaaag gcctggaatg ggtgtcctac atcagctcca gcggcagcac catctactac 180
gccgatagcg tgaagggcag attcaccatc agccgggaca acgccaagaa cagcctgtac 240
ctgcagatga actccctgag agccgaggac accgccgtgt actactgtgc cagagatggc 300
tatcctcttg gcggaggcta cgacttttgg agcggctact accccgatta ctggggccag 360
ggaacactgg tcacagtgtc tagtggtggc ggaggatctg gcggaggtgg aagcggcgga 420
ggcggatctg acatccagat gacacagagc cctagcagcc tgtctgccag cgtgggagac 480
agagtgacca tcacctgtag agccagccag agcatcagca gctacctgaa ctggtatcag 540
cagaagcccg gcaaggcccc taaactgctg atctatgccg ccagctctct gcagtctggc 600
gtgccatcta gattttccgg cagcggctct ggcaccgact tcaccctgac catatctagc 660
ctgcagcctg aggatatcgc cgcctactac tgtcagcact acggcacatt tggccagggc 720
accaagctgg aaatcaagag a                                           741

<210> 210
<211> 495
<212> PRT
<213> Artificial Sequence

<220> 
<223> RJ152LH CAR (D7LH/CD8 TM/4-1BB/CD3zeta)

<400> 210
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser
            20                  25                  30          
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
        35                  40                  45              
Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys
    50                  55                  60                  
Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val
65                  70                  75                  80  
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
                85                  90                  95      
Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Ala Tyr Tyr Cys Gln His
            100                 105                 110         
Tyr Gly Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln
    130                 135                 140                 
Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg
145                 150                 155                 160 
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr Tyr Met Ser
                165                 170                 175     
Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Tyr Ile
            180                 185                 190         
Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg
        195                 200                 205             
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met
    210                 215                 220                 
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp
225                 230                 235                 240 
Gly Tyr Pro Leu Gly Gly Gly Tyr Asp Phe Trp Ser Gly Tyr Tyr Pro
                245                 250                 255     
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala
            260                 265                 270         
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala
        275                 280                 285             
Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly
    290                 295                 300                 
Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile
305                 310                 315                 320 
Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val
                325                 330                 335     
Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe
            340                 345                 350         
Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly
        355                 360                 365             
Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg
    370                 375                 380                 
Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln
385                 390                 395                 400 
Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp
                405                 410                 415     
Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro
            420                 425                 430         
Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp
        435                 440                 445             
Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg
    450                 455                 460                 
Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr
465                 470                 475                 480 
Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
                485                 490                 495

<210> 211
<211> 1485
<212> DNA
<213> Artificial Sequence

<220> 
<223> RJ152LH CAR (D7LH/CD8 TM/4-1BB/CD3zeta)

<400> 211
atgcttctgc tcgtgacaag cctgctgctg tgcgagctgc cccaccctgc ctttctgctg 60
atccctgaca tccagatgac acagagccct agcagcctgt ctgccagcgt gggagacaga 120
gtgaccatca cctgtagagc cagccagagc atcagcagct acctgaactg gtatcagcag 180
aagcccggca aggcccctaa actgctgatc tatgccgcca gctctctgca gtctggcgtg 240
ccatctagat tttccggcag cggctctggc accgacttca ccctgaccat atctagcctg 300
cagcctgagg atatcgccgc ctactactgt cagcactacg gcacatttgg ccagggcacc 360
aagctggaaa tcaagagagg tggcggagga tctggcggag gtggaagcgg cggaggcgga 420
tctcaagttc agctggttga atctggcggc ggactggtta agcctggcgg ttctctgaga 480
ctgagctgtg ccgcctccgg cttcaccttc agcgactact acatgagctg gatcagacag 540
gcccctggca aaggcctgga atgggtgtcc tacatcagct ccagcggcag caccatctac 600
tacgccgata gcgtgaaggg cagattcacc atcagccggg acaacgccaa gaacagcctg 660
tacctgcaga tgaactccct gagagccgag gacaccgccg tgtactactg tgccagagat 720
ggctatcctc ttggcggagg ctacgacttt tggagcggct actaccccga ttactggggc 780
cagggaacac tggtcacagt gtctagtgcg gccgcaacca ctactccggc acctaggccc 840
cccactccgg caccgaccat tgcatcacaa ccactgagtc ttagacctga agcctgtcga 900
cccgcagctg ggggggcagt ccacacacgg ggattggatt tcgcctgcga tatatacatt 960
tgggcgccac tggcaggcac ctgcggggtc ctgctcttgt cccttgtcat caccctgtac 1020
tgtaagagag gaagaaagaa gttgttgtat attttcaaac agccattcat gaggccggtc 1080
cagaccactc aggaggagga tggatgcagt tgccgctttc cggaagagga agagggtggg 1140
tgtgaactcc gagttaaatt ttctcgcagt gctgatgccc cagcgtataa acagggtcag 1200
aaccaactgt ataatgaact caatttgggg aggcgagagg agtatgatgt attggacaag 1260
cggcgggggc gggatcctga aatgggcggt aagccaaggc gcaagaatcc acaggagggt 1320
ttgtataatg agttgcagaa ggataaaatg gcggaagcgt attcagaaat cggaatgaag 1380
ggagagcgcc gcagagggaa agggcatgat ggcctctacc aaggtttgtc aacagcgacc 1440
aaggatacct atgacgcact tcatatgcaa gcactgcccc ccagg                 1485

<210> 212
<211> 495
<212> PRT
<213> Artificial Sequence

<220> 
<223> RJ152HL (D7HL/CD8 TM/4-1BB/CD3zeta)

<400> 212
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly
            20                  25                  30          
Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly
        35                  40                  45              
Phe Thr Phe Ser Asp Tyr Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly
    50                  55                  60                  
Lys Gly Leu Glu Trp Val Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile
65                  70                  75                  80  
Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
                85                  90                  95      
Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
            100                 105                 110         
Thr Ala Val Tyr Tyr Cys Ala Arg Asp Gly Tyr Pro Leu Gly Gly Gly
        115                 120                 125             
Tyr Asp Phe Trp Ser Gly Tyr Tyr Pro Asp Tyr Trp Gly Gln Gly Thr
    130                 135                 140                 
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
145                 150                 155                 160 
Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
                165                 170                 175     
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln
            180                 185                 190         
Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala
        195                 200                 205             
Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro
    210                 215                 220                 
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
225                 230                 235                 240 
Ser Ser Leu Gln Pro Glu Asp Ile Ala Ala Tyr Tyr Cys Gln His Tyr
                245                 250                 255     
Gly Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala
            260                 265                 270         
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala
        275                 280                 285             
Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly
    290                 295                 300                 
Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile
305                 310                 315                 320 
Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val
                325                 330                 335     
Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe
            340                 345                 350         
Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly
        355                 360                 365             
Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg
    370                 375                 380                 
Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln
385                 390                 395                 400 
Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp
                405                 410                 415     
Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro
            420                 425                 430         
Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp
        435                 440                 445             
Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg
    450                 455                 460                 
Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr
465                 470                 475                 480 
Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
                485                 490                 495

<210> 213
<211> 1485
<212> DNA
<213> Artificial Sequence

<220> 
<223> RJ152HL (D7HL/CD8 TM/4-1BB/CD3zeta)

<400> 213
atgcttctgc tcgtgacaag cctgctgctg tgcgagctgc cccaccctgc ctttctgctg 60
atccctcaag ttcagctggt tgaatctggc ggcggactgg ttaagcctgg cggttctctg 120
agactgagct gtgccgcctc cggcttcacc ttcagcgact actacatgag ctggatcaga 180
caggcccctg gcaaaggcct ggaatgggtg tcctacatca gctccagcgg cagcaccatc 240
tactacgccg atagcgtgaa gggcagattc accatcagcc gggacaacgc caagaacagc 300
ctgtacctgc agatgaactc cctgagagcc gaggacaccg ccgtgtacta ctgtgccaga 360
gatggctatc ctcttggcgg aggctacgac ttttggagcg gctactaccc cgattactgg 420
ggccagggaa cactggtcac agtgtctagt ggtggcggag gatctggcgg aggtggaagc 480
ggcggaggcg gatctgacat ccagatgaca cagagcccta gcagcctgtc tgccagcgtg 540
ggagacagag tgaccatcac ctgtagagcc agccagagca tcagcagcta cctgaactgg 600
tatcagcaga agcccggcaa ggcccctaaa ctgctgatct atgccgccag ctctctgcag 660
tctggcgtgc catctagatt ttccggcagc ggctctggca ccgacttcac cctgaccata 720
tctagcctgc agcctgagga tatcgccgcc tactactgtc agcactacgg cacatttggc 780
cagggcacca agctggaaat caagagagcg gccgcaacca ctactccggc acctaggccc 840
cccactccgg caccgaccat tgcatcacaa ccactgagtc ttagacctga agcctgtcga 900
cccgcagctg ggggggcagt ccacacacgg ggattggatt tcgcctgcga tatatacatt 960
tgggcgccac tggcaggcac ctgcggggtc ctgctcttgt cccttgtcat caccctgtac 1020
tgtaagagag gaagaaagaa gttgttgtat attttcaaac agccattcat gaggccggtc 1080
cagaccactc aggaggagga tggatgcagt tgccgctttc cggaagagga agagggtggg 1140
tgtgaactcc gagttaaatt ttctcgcagt gctgatgccc cagcgtataa acagggtcag 1200
aaccaactgt ataatgaact caatttgggg aggcgagagg agtatgatgt attggacaag 1260
cggcgggggc gggatcctga aatgggcggt aagccaaggc gcaagaatcc acaggagggt 1320
ttgtataatg agttgcagaa ggataaaatg gcggaagcgt attcagaaat cggaatgaag 1380
ggagagcgcc gcagagggaa agggcatgat ggcctctacc aaggtttgtc aacagcgacc 1440
aaggatacct atgacgcact tcatatgcaa gcactgcccc ccagg                 1485

<210> 214
<211> 104
<212> PRT
<213> Artificial Sequence

<220> 
<223> B7 L chain

<400> 214
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Gly Thr Phe Gly Gln
                85                  90                  95      
Gly Thr Lys Val Glu Ile Lys Arg
            100

<210> 215
<211> 312
<212> DNA
<213> Artificial Sequence

<220> 
<223> B7 L chain

<400> 215
gacatccaga tgacacagag ccctagcagc ctgtctgcca gcgtgggaga cagagtgacc 60
atcacctgta gagccagcca gagcatcagc agctacctga actggtatca gcagaagccc 120
ggcaaggccc ctaaactgct gatctatgcc gccagctctc tgcagtctgg cgtgccatct 180
agattttccg gcagcggctc tggcaccgac ttcaccctga ccatatctag cctgcagcct 240
gaggacttcg ccgtgtacta ctgtcagcac tacggcacct ttggccaggg caccaaggtg 300
gaaatcaaga ga                                                     312

<210> 216
<211> 127
<212> PRT
<213> Artificial Sequence

<220> 
<223> B7 H chain

<400> 216
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
            20                  25                  30          
Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg His Lys Thr Ser Leu Asn Asp Tyr Asp Phe Trp Ser Gly Tyr
            100                 105                 110         
Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125

<210> 217
<211> 381
<212> DNA
<213> Artificial Sequence

<220> 
<223> B7 H chain

<400> 217
caagttcagc tggttgaatc tggcggcgga ctggttaagc ctggcggttc tctgagactg 60
agctgtgccg cctccggctt caccttcagc gactactaca tgagctggat cagacaggcc 120
cctggcaaag gcctggaatg ggtgtcctac atcagctcca gcggcagcac catctactac 180
gccgatagcg tgaagggcag attcaccatc agccgggaca acgccaagaa cagcctgtac 240
ctgcagatga actccctgag agccgaggac acagccatgt actattgcgc cagacacaag 300
accagcctga acgactacga cttttggagc ggctacctgc tggactattg gggccaggga 360
acactggtca ccgtgtctag t                                           381

<210> 218
<211> 738
<212> DNA
<213> Artificial Sequence

<220> 
<223> B7LH binder

<400> 218
gacatccaga tgacacagag ccctagcagc ctgtctgcca gcgtgggaga cagagtgacc 60
atcacctgta gagccagcca gagcatcagc agctacctga actggtatca gcagaagccc 120
ggcaaggccc ctaaactgct gatctatgcc gccagctctc tgcagtctgg cgtgccatct 180
agattttccg gcagcggctc tggcaccgac ttcaccctga ccatatctag cctgcagcct 240
gaggacttcg ccgtgtacta ctgtcagcac tacggcacct ttggccaggg caccaaggtg 300
gaaatcaaga gaggtggcgg aggatctggc ggaggtggaa gcggcggagg cggatctcaa 360
gttcagctgg ttgaatctgg cggcggactg gttaagcctg gcggttctct gagactgagc 420
tgtgccgcct ccggcttcac cttcagcgac tactacatga gctggatcag acaggcccct 480
ggcaaaggcc tggaatgggt gtcctacatc agctccagcg gcagcaccat ctactacgcc 540
gatagcgtga agggcagatt caccatcagc cgggacaacg ccaagaacag cctgtacctg 600
cagatgaact ccctgagagc cgaggacaca gccatgtact attgcgccag acacaagacc 660
agcctgaacg actacgactt ttggagcggc tacctgctgg actattgggg ccagggaaca 720
ctggtcaccg tgtctagt                                               738

<210> 219
<211> 738
<212> DNA
<213> Artificial Sequence

<220> 
<223> B7HL binder

<400> 219
caagttcagc tggttgaatc tggcggcgga ctggttaagc ctggcggttc tctgagactg 60
agctgtgccg cctccggctt caccttcagc gactactaca tgagctggat cagacaggcc 120
cctggcaaag gcctggaatg ggtgtcctac atcagctcca gcggcagcac catctactac 180
gccgatagcg tgaagggcag attcaccatc agccgggaca acgccaagaa cagcctgtac 240
ctgcagatga actccctgag agccgaggac acagccatgt actattgcgc cagacacaag 300
accagcctga acgactacga cttttggagc ggctacctgc tggactattg gggccaggga 360
acactggtca ccgtgtctag tggtggcgga ggatctggcg gaggtggaag cggcggaggc 420
ggatctgaca tccagatgac acagagccct agcagcctgt ctgccagcgt gggagacaga 480
gtgaccatca cctgtagagc cagccagagc atcagcagct acctgaactg gtatcagcag 540
aagcccggca aggcccctaa actgctgatc tatgccgcca gctctctgca gtctggcgtg 600
ccatctagat tttccggcag cggctctggc accgacttca ccctgaccat atctagcctg 660
cagcctgagg acttcgccgt gtactactgt cagcactacg gcacctttgg ccagggcacc 720
aaggtggaaa tcaagaga                                               738

<210> 220
<211> 494
<212> PRT
<213> Artificial Sequence

<220> 
<223> RJ153LH CAR (B7LH/CD8 TM/4-1BB/CD3zeta)

<400> 220
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser
            20                  25                  30          
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
        35                  40                  45              
Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys
    50                  55                  60                  
Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val
65                  70                  75                  80  
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
                85                  90                  95      
Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His
            100                 105                 110         
Tyr Gly Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln
    130                 135                 140                 
Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg
145                 150                 155                 160 
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr Tyr Met Ser
                165                 170                 175     
Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Tyr Ile
            180                 185                 190         
Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg
        195                 200                 205             
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met
    210                 215                 220                 
Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg His
225                 230                 235                 240 
Lys Thr Ser Leu Asn Asp Tyr Asp Phe Trp Ser Gly Tyr Leu Leu Asp
                245                 250                 255     
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Thr
            260                 265                 270         
Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser
        275                 280                 285             
Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly
    290                 295                 300                 
Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp
305                 310                 315                 320 
Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile
                325                 330                 335     
Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys
            340                 345                 350         
Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys
        355                 360                 365             
Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val
    370                 375                 380                 
Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn
385                 390                 395                 400 
Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val
                405                 410                 415     
Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg
            420                 425                 430         
Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys
        435                 440                 445             
Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg
    450                 455                 460                 
Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys
465                 470                 475                 480 
Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
                485                 490

<210> 221
<211> 1482
<212> DNA
<213> Artificial Sequence

<220> 
<223> RJ153LH CAR (B7LH/CD8 TM/4-1BB/CD3zeta)

<400> 221
atgcttctgc tcgtgacaag cctgctgctg tgcgagctgc cccaccctgc ctttctgctg 60
atccctgaca tccagatgac acagagccct agcagcctgt ctgccagcgt gggagacaga 120
gtgaccatca cctgtagagc cagccagagc atcagcagct acctgaactg gtatcagcag 180
aagcccggca aggcccctaa actgctgatc tatgccgcca gctctctgca gtctggcgtg 240
ccatctagat tttccggcag cggctctggc accgacttca ccctgaccat atctagcctg 300
cagcctgagg acttcgccgt gtactactgt cagcactacg gcacctttgg ccagggcacc 360
aaggtggaaa tcaagagagg tggcggagga tctggcggag gtggaagcgg cggaggcgga 420
tctcaagttc agctggttga atctggcggc ggactggtta agcctggcgg ttctctgaga 480
ctgagctgtg ccgcctccgg cttcaccttc agcgactact acatgagctg gatcagacag 540
gcccctggca aaggcctgga atgggtgtcc tacatcagct ccagcggcag caccatctac 600
tacgccgata gcgtgaaggg cagattcacc atcagccggg acaacgccaa gaacagcctg 660
tacctgcaga tgaactccct gagagccgag gacacagcca tgtactattg cgccagacac 720
aagaccagcc tgaacgacta cgacttttgg agcggctacc tgctggacta ttggggccag 780
ggaacactgg tcaccgtgtc tagtgcggcc gcaaccacta ctccggcacc taggcccccc 840
actccggcac cgaccattgc atcacaacca ctgagtctta gacctgaagc ctgtcgaccc 900
gcagctgggg gggcagtcca cacacgggga ttggatttcg cctgcgatat atacatttgg 960
gcgccactgg caggcacctg cggggtcctg ctcttgtccc ttgtcatcac cctgtactgt 1020
aagagaggaa gaaagaagtt gttgtatatt ttcaaacagc cattcatgag gccggtccag 1080
accactcagg aggaggatgg atgcagttgc cgctttccgg aagaggaaga gggtgggtgt 1140
gaactccgag ttaaattttc tcgcagtgct gatgccccag cgtataaaca gggtcagaac 1200
caactgtata atgaactcaa tttggggagg cgagaggagt atgatgtatt ggacaagcgg 1260
cgggggcggg atcctgaaat gggcggtaag ccaaggcgca agaatccaca ggagggtttg 1320
tataatgagt tgcagaagga taaaatggcg gaagcgtatt cagaaatcgg aatgaaggga 1380
gagcgccgca gagggaaagg gcatgatggc ctctaccaag gtttgtcaac agcgaccaag 1440
gatacctatg acgcacttca tatgcaagca ctgcccccca gg                    1482

<210> 222
<211> 494
<212> PRT
<213> Artificial Sequence

<220> 
<223> RJ153HL CAR (B7HL/CD8 TM/4-1BB/CD3zeta)

<400> 222
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly
            20                  25                  30          
Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly
        35                  40                  45              
Phe Thr Phe Ser Asp Tyr Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly
    50                  55                  60                  
Lys Gly Leu Glu Trp Val Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile
65                  70                  75                  80  
Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
                85                  90                  95      
Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
            100                 105                 110         
Thr Ala Met Tyr Tyr Cys Ala Arg His Lys Thr Ser Leu Asn Asp Tyr
        115                 120                 125             
Asp Phe Trp Ser Gly Tyr Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu
    130                 135                 140                 
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
145                 150                 155                 160 
Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser
                165                 170                 175     
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser
            180                 185                 190         
Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro
        195                 200                 205             
Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser
    210                 215                 220                 
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
225                 230                 235                 240 
Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Gly
                245                 250                 255     
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Ala Ala Ala Thr
            260                 265                 270         
Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser
        275                 280                 285             
Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly
    290                 295                 300                 
Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp
305                 310                 315                 320 
Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile
                325                 330                 335     
Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys
            340                 345                 350         
Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys
        355                 360                 365             
Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val
    370                 375                 380                 
Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn
385                 390                 395                 400 
Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val
                405                 410                 415     
Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg
            420                 425                 430         
Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys
        435                 440                 445             
Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg
    450                 455                 460                 
Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys
465                 470                 475                 480 
Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
                485                 490

<210> 223
<211> 1482
<212> DNA
<213> Artificial Sequence

<220> 
<223> RJ153HL CAR (B7HL/CD8 TM/4-1BB/CD3zeta)

<400> 223
atgcttctgc tcgtgacaag cctgctgctg tgcgagctgc cccaccctgc ctttctgctg 60
atccctcaag ttcagctggt tgaatctggc ggcggactgg ttaagcctgg cggttctctg 120
agactgagct gtgccgcctc cggcttcacc ttcagcgact actacatgag ctggatcaga 180
caggcccctg gcaaaggcct ggaatgggtg tcctacatca gctccagcgg cagcaccatc 240
tactacgccg atagcgtgaa gggcagattc accatcagcc gggacaacgc caagaacagc 300
ctgtacctgc agatgaactc cctgagagcc gaggacacag ccatgtacta ttgcgccaga 360
cacaagacca gcctgaacga ctacgacttt tggagcggct acctgctgga ctattggggc 420
cagggaacac tggtcaccgt gtctagtggt ggcggaggat ctggcggagg tggaagcggc 480
ggaggcggat ctgacatcca gatgacacag agccctagca gcctgtctgc cagcgtggga 540
gacagagtga ccatcacctg tagagccagc cagagcatca gcagctacct gaactggtat 600
cagcagaagc ccggcaaggc ccctaaactg ctgatctatg ccgccagctc tctgcagtct 660
ggcgtgccat ctagattttc cggcagcggc tctggcaccg acttcaccct gaccatatct 720
agcctgcagc ctgaggactt cgccgtgtac tactgtcagc actacggcac ctttggccag 780
ggcaccaagg tggaaatcaa gagagcggcc gcaaccacta ctccggcacc taggcccccc 840
actccggcac cgaccattgc atcacaacca ctgagtctta gacctgaagc ctgtcgaccc 900
gcagctgggg gggcagtcca cacacgggga ttggatttcg cctgcgatat atacatttgg 960
gcgccactgg caggcacctg cggggtcctg ctcttgtccc ttgtcatcac cctgtactgt 1020
aagagaggaa gaaagaagtt gttgtatatt ttcaaacagc cattcatgag gccggtccag 1080
accactcagg aggaggatgg atgcagttgc cgctttccgg aagaggaaga gggtgggtgt 1140
gaactccgag ttaaattttc tcgcagtgct gatgccccag cgtataaaca gggtcagaac 1200
caactgtata atgaactcaa tttggggagg cgagaggagt atgatgtatt ggacaagcgg 1260
cgggggcggg atcctgaaat gggcggtaag ccaaggcgca agaatccaca ggagggtttg 1320
tataatgagt tgcagaagga taaaatggcg gaagcgtatt cagaaatcgg aatgaaggga 1380
gagcgccgca gagggaaagg gcatgatggc ctctaccaag gtttgtcaac agcgaccaag 1440
gatacctatg acgcacttca tatgcaagca ctgcccccca gg                    1482

<210> 224
<211> 104
<212> PRT
<213> Artificial Sequence

<220> 
<223> A6 L chain

<400> 224
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Arg Tyr Gly Thr Phe Gly Gln
                85                  90                  95      
Gly Thr Lys Val Asp Ile Lys Arg
            100

<210> 225
<211> 312
<212> DNA
<213> Artificial Sequence

<220> 
<223> A6 L chain

<400> 225
gacatccaga tgacacagag ccctagcagc ctgtctgcca gcgtgggaga cagagtgacc 60
atcacctgta gagccagcca gagcatcagc agctacctga actggtatca gcagaagccc 120
ggcaaggccc ctaaactgct gatctatgcc gccagctctc tgcagtctgg cgtgccatct 180
agattttccg gcagcggctc tggcaccgac ttcaccctga ccatatctag cctgcagcct 240
gaggatgccg ccacctacta ctgtcagaga tacggcacat tcggccaggg caccaaggtg 300
gacattaaga ga                                                     312

<210> 226
<211> 127
<212> PRT
<213> Artificial Sequence

<220> 
<223> A6 H chain

<400> 226
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
            20                  25                  30          
Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg His Lys Thr Ser Leu Asn Asp Tyr Asp Phe Trp Ser Gly Tyr
            100                 105                 110         
Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125

<210> 227
<211> 381
<212> DNA
<213> Artificial Sequence

<220> 
<223> A6 H chain

<400> 227
caagttcagc tggttgaatc tggcggcgga ctggttaagc ctggcggttc tctgagactg 60
agctgtgccg cctccggctt caccttcagc gactactaca tgagctggat cagacaggcc 120
cctggcaaag gcctggaatg ggtgtcctac atcagctcca gcggcagcac catctactac 180
gccgatagcg tgaagggcag attcaccatc agccgggaca acgccaagaa cagcctgtac 240
ctgcagatga actccctgag agccgaggac accgccgtgt actattgcgc cagacacaag 300
accagcctga acgactacga cttttggagc ggctacctgc tggactattg gggccaggga 360
acactggtca ccgtgtctag t                                           381

<210> 228
<211> 738
<212> DNA
<213> Artificial Sequence

<220> 
<223> A6LH binder

<400> 228
gacatccaga tgacacagag ccctagcagc ctgtctgcca gcgtgggaga cagagtgacc 60
atcacctgta gagccagcca gagcatcagc agctacctga actggtatca gcagaagccc 120
ggcaaggccc ctaaactgct gatctatgcc gccagctctc tgcagtctgg cgtgccatct 180
agattttccg gcagcggctc tggcaccgac ttcaccctga ccatatctag cctgcagcct 240
gaggatgccg ccacctacta ctgtcagaga tacggcacat tcggccaggg caccaaggtg 300
gacattaaga gaggtggcgg aggatctggc ggaggtggaa gcggcggagg cggatctcaa 360
gttcagctgg ttgaatctgg cggcggactg gttaagcctg gcggttctct gagactgagc 420
tgtgccgcct ccggcttcac cttcagcgac tactacatga gctggatcag acaggcccct 480
ggcaaaggcc tggaatgggt gtcctacatc agctccagcg gcagcaccat ctactacgcc 540
gatagcgtga agggcagatt caccatcagc cgggacaacg ccaagaacag cctgtacctg 600
cagatgaact ccctgagagc cgaggacacc gccgtgtact attgcgccag acacaagacc 660
agcctgaacg actacgactt ttggagcggc tacctgctgg actattgggg ccagggaaca 720
ctggtcaccg tgtctagt                                               738

<210> 229
<211> 738
<212> DNA
<213> Artificial Sequence

<220> 
<223> A6HL binder

<400> 229
caagttcagc tggttgaatc tggcggcgga ctggttaagc ctggcggttc tctgagactg 60
agctgtgccg cctccggctt caccttcagc gactactaca tgagctggat cagacaggcc 120
cctggcaaag gcctggaatg ggtgtcctac atcagctcca gcggcagcac catctactac 180
gccgatagcg tgaagggcag attcaccatc agccgggaca acgccaagaa cagcctgtac 240
ctgcagatga actccctgag agccgaggac accgccgtgt actattgcgc cagacacaag 300
accagcctga acgactacga cttttggagc ggctacctgc tggactattg gggccaggga 360
acactggtca ccgtgtctag tggtggcgga ggatctggcg gaggtggaag cggcggaggc 420
ggatctgaca tccagatgac acagagccct agcagcctgt ctgccagcgt gggagacaga 480
gtgaccatca cctgtagagc cagccagagc atcagcagct acctgaactg gtatcagcag 540
aagcccggca aggcccctaa actgctgatc tatgccgcca gctctctgca gtctggcgtg 600
ccatctagat tttccggcag cggctctggc accgacttca ccctgaccat atctagcctg 660
cagcctgagg atgccgccac ctactactgt cagagatacg gcacattcgg ccagggcacc 720
aaggtggaca ttaagaga                                               738

<210> 230
<211> 494
<212> PRT
<213> Artificial Sequence

<220> 
<223> RJ154LH CAR (A6LH/CD8 TM/4-1BB/CD3zeta)

<400> 230
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser
            20                  25                  30          
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
        35                  40                  45              
Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys
    50                  55                  60                  
Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val
65                  70                  75                  80  
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
                85                  90                  95      
Ile Ser Ser Leu Gln Pro Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Arg
            100                 105                 110         
Tyr Gly Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys Arg Gly Gly
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln
    130                 135                 140                 
Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg
145                 150                 155                 160 
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr Tyr Met Ser
                165                 170                 175     
Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Tyr Ile
            180                 185                 190         
Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg
        195                 200                 205             
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met
    210                 215                 220                 
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg His
225                 230                 235                 240 
Lys Thr Ser Leu Asn Asp Tyr Asp Phe Trp Ser Gly Tyr Leu Leu Asp
                245                 250                 255     
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Thr
            260                 265                 270         
Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser
        275                 280                 285             
Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly
    290                 295                 300                 
Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp
305                 310                 315                 320 
Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile
                325                 330                 335     
Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys
            340                 345                 350         
Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys
        355                 360                 365             
Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val
    370                 375                 380                 
Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn
385                 390                 395                 400 
Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val
                405                 410                 415     
Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg
            420                 425                 430         
Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys
        435                 440                 445             
Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg
    450                 455                 460                 
Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys
465                 470                 475                 480 
Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
                485                 490

<210> 231
<211> 1482
<212> DNA
<213> art6ificial sequence

<220> 
<223> RJ154LH CAR (A6LH/CD8 TM/4-1BB/CD3zeta)

<400> 231
atgcttctgc tcgtgacaag cctgctgctg tgcgagctgc cccaccctgc ctttctgctg 60
atccctgaca tccagatgac acagagccct agcagcctgt ctgccagcgt gggagacaga 120
gtgaccatca cctgtagagc cagccagagc atcagcagct acctgaactg gtatcagcag 180
aagcccggca aggcccctaa actgctgatc tatgccgcca gctctctgca gtctggcgtg 240
ccatctagat tttccggcag cggctctggc accgacttca ccctgaccat atctagcctg 300
cagcctgagg atgccgccac ctactactgt cagagatacg gcacattcgg ccagggcacc 360
aaggtggaca ttaagagagg tggcggagga tctggcggag gtggaagcgg cggaggcgga 420
tctcaagttc agctggttga atctggcggc ggactggtta agcctggcgg ttctctgaga 480
ctgagctgtg ccgcctccgg cttcaccttc agcgactact acatgagctg gatcagacag 540
gcccctggca aaggcctgga atgggtgtcc tacatcagct ccagcggcag caccatctac 600
tacgccgata gcgtgaaggg cagattcacc atcagccggg acaacgccaa gaacagcctg 660
tacctgcaga tgaactccct gagagccgag gacaccgccg tgtactattg cgccagacac 720
aagaccagcc tgaacgacta cgacttttgg agcggctacc tgctggacta ttggggccag 780
ggaacactgg tcaccgtgtc tagtgcggcc gcaaccacta ctccggcacc taggcccccc 840
actccggcac cgaccattgc atcacaacca ctgagtctta gacctgaagc ctgtcgaccc 900
gcagctgggg gggcagtcca cacacgggga ttggatttcg cctgcgatat atacatttgg 960
gcgccactgg caggcacctg cggggtcctg ctcttgtccc ttgtcatcac cctgtactgt 1020
aagagaggaa gaaagaagtt gttgtatatt ttcaaacagc cattcatgag gccggtccag 1080
accactcagg aggaggatgg atgcagttgc cgctttccgg aagaggaaga gggtgggtgt 1140
gaactccgag ttaaattttc tcgcagtgct gatgccccag cgtataaaca gggtcagaac 1200
caactgtata atgaactcaa tttggggagg cgagaggagt atgatgtatt ggacaagcgg 1260
cgggggcggg atcctgaaat gggcggtaag ccaaggcgca agaatccaca ggagggtttg 1320
tataatgagt tgcagaagga taaaatggcg gaagcgtatt cagaaatcgg aatgaaggga 1380
gagcgccgca gagggaaagg gcatgatggc ctctaccaag gtttgtcaac agcgaccaag 1440
gatacctatg acgcacttca tatgcaagca ctgcccccca gg                    1482

<210> 232
<211> 494
<212> PRT
<213> Artificial Sequence

<220> 
<223> RJ154HL CAR (A6HL/CD8 TM/4-1BB/CD3zeta)

<400> 232
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly
            20                  25                  30          
Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly
        35                  40                  45              
Phe Thr Phe Ser Asp Tyr Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly
    50                  55                  60                  
Lys Gly Leu Glu Trp Val Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile
65                  70                  75                  80  
Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
                85                  90                  95      
Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
            100                 105                 110         
Thr Ala Val Tyr Tyr Cys Ala Arg His Lys Thr Ser Leu Asn Asp Tyr
        115                 120                 125             
Asp Phe Trp Ser Gly Tyr Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu
    130                 135                 140                 
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
145                 150                 155                 160 
Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser
                165                 170                 175     
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser
            180                 185                 190         
Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro
        195                 200                 205             
Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser
    210                 215                 220                 
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
225                 230                 235                 240 
Ser Leu Gln Pro Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Arg Tyr Gly
                245                 250                 255     
Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys Arg Ala Ala Ala Thr
            260                 265                 270         
Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser
        275                 280                 285             
Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly
    290                 295                 300                 
Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp
305                 310                 315                 320 
Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile
                325                 330                 335     
Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys
            340                 345                 350         
Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys
        355                 360                 365             
Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val
    370                 375                 380                 
Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn
385                 390                 395                 400 
Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val
                405                 410                 415     
Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg
            420                 425                 430         
Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys
        435                 440                 445             
Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg
    450                 455                 460                 
Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys
465                 470                 475                 480 
Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
                485                 490

<210> 233
<211> 1482
<212> DNA
<213> Artificial Sequence

<220> 
<223> RJ154HL CAR (A6HL/CD8 TM/4-1BB/CD3zeta)

<400> 233
atgcttctgc tcgtgacaag cctgctgctg tgcgagctgc cccaccctgc ctttctgctg 60
atccctcaag ttcagctggt tgaatctggc ggcggactgg ttaagcctgg cggttctctg 120
agactgagct gtgccgcctc cggcttcacc ttcagcgact actacatgag ctggatcaga 180
caggcccctg gcaaaggcct ggaatgggtg tcctacatca gctccagcgg cagcaccatc 240
tactacgccg atagcgtgaa gggcagattc accatcagcc gggacaacgc caagaacagc 300
ctgtacctgc agatgaactc cctgagagcc gaggacaccg ccgtgtacta ttgcgccaga 360
cacaagacca gcctgaacga ctacgacttt tggagcggct acctgctgga ctattggggc 420
cagggaacac tggtcaccgt gtctagtggt ggcggaggat ctggcggagg tggaagcggc 480
ggaggcggat ctgacatcca gatgacacag agccctagca gcctgtctgc cagcgtggga 540
gacagagtga ccatcacctg tagagccagc cagagcatca gcagctacct gaactggtat 600
cagcagaagc ccggcaaggc ccctaaactg ctgatctatg ccgccagctc tctgcagtct 660
ggcgtgccat ctagattttc cggcagcggc tctggcaccg acttcaccct gaccatatct 720
agcctgcagc ctgaggatgc cgccacctac tactgtcaga gatacggcac attcggccag 780
ggcaccaagg tggacattaa gagagcggcc gcaaccacta ctccggcacc taggcccccc 840
actccggcac cgaccattgc atcacaacca ctgagtctta gacctgaagc ctgtcgaccc 900
gcagctgggg gggcagtcca cacacgggga ttggatttcg cctgcgatat atacatttgg 960
gcgccactgg caggcacctg cggggtcctg ctcttgtccc ttgtcatcac cctgtactgt 1020
aagagaggaa gaaagaagtt gttgtatatt ttcaaacagc cattcatgag gccggtccag 1080
accactcagg aggaggatgg atgcagttgc cgctttccgg aagaggaaga gggtgggtgt 1140
gaactccgag ttaaattttc tcgcagtgct gatgccccag cgtataaaca gggtcagaac 1200
caactgtata atgaactcaa tttggggagg cgagaggagt atgatgtatt ggacaagcgg 1260
cgggggcggg atcctgaaat gggcggtaag ccaaggcgca agaatccaca ggagggtttg 1320
tataatgagt tgcagaagga taaaatggcg gaagcgtatt cagaaatcgg aatgaaggga 1380
gagcgccgca gagggaaagg gcatgatggc ctctaccaag gtttgtcaac agcgaccaag 1440
gatacctatg acgcacttca tatgcaagca ctgcccccca gg                    1482

<210> 234
<211> 104
<212> PRT
<213> Artificial Sequence

<220> 
<223> C1 L chain

<400> 234
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Tyr Gly Thr Phe Gly Gln
                85                  90                  95      
Gly Thr Lys Val Glu Ile Lys Arg
            100

<210> 235
<211> 312
<212> DNA
<213> Artificial Sequence

<220> 
<223> C1 L chain

<400> 235
gacatccaga tgacacagag ccctagcagc ctgtctgcca gcgtgggaga cagagtgacc 60
atcacctgta gagccagcca gagcatcagc agctacctga actggtatca gcagaagccc 120
ggcaaggccc ctaaactgct gatctatgcc gccagctctc tgcagtctgg cgtgccatct 180
agattttccg gcagcggctc tggcaccgac ttcaccctga ccatatctag cctgcagcct 240
gaggatgccg ccacctacta ctgtcagcac tacggcacat ttggccaggg caccaaggtg 300
gaaatcaaga ga                                                     312

<210> 236
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> C1 H chain

<400> 236
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
            20                  25                  30          
Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg His Ala Pro His Lys His Tyr Asp Phe Trp Ser Gly Tyr Tyr
            100                 105                 110         
Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125

<210> 237
<211> 378
<212> DNA
<213> Artificial Sequence

<220> 
<223> C1 H chain

<400> 237
caagttcagc tggttgaatc tggcggcgga ctggttaagc ctggcggttc tctgagactg 60
agctgtgccg cctccggctt caccttcagc gactactaca tgagctggat cagacaggcc 120
cctggcaaag gcctggaatg ggtgtcctac atcagctcca gcggcagcac catctactac 180
gccgatagcg tgaagggcag attcaccatc agccgggaca acgccaagaa cagcctgtac 240
ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagacacgcc 300
cctcacaagc actacgactt ttggagcggc tactaccccg actattgggg ccagggaaca 360
ctggtcacag tgtcctct                                               378

<210> 238
<211> 735
<212> DNA
<213> Artificial Sequence

<220> 
<223> C1LH binder

<400> 238
gacatccaga tgacacagag ccctagcagc ctgtctgcca gcgtgggaga cagagtgacc 60
atcacctgta gagccagcca gagcatcagc agctacctga actggtatca gcagaagccc 120
ggcaaggccc ctaaactgct gatctatgcc gccagctctc tgcagtctgg cgtgccatct 180
agattttccg gcagcggctc tggcaccgac ttcaccctga ccatatctag cctgcagcct 240
gaggatgccg ccacctacta ctgtcagcac tacggcacat ttggccaggg caccaaggtg 300
gaaatcaaga gaggtggcgg aggatctggc ggaggtggaa gcggcggagg cggatctcaa 360
gttcagctgg ttgaatctgg cggcggactg gttaagcctg gcggttctct gagactgagc 420
tgtgccgcct ccggcttcac cttcagcgac tactacatga gctggatcag acaggcccct 480
ggcaaaggcc tggaatgggt gtcctacatc agctccagcg gcagcaccat ctactacgcc 540
gatagcgtga agggcagatt caccatcagc cgggacaacg ccaagaacag cctgtacctg 600
cagatgaact ccctgagagc cgaggacacc gccgtgtact attgtgccag acacgcccct 660
cacaagcact acgacttttg gagcggctac taccccgact attggggcca gggaacactg 720
gtcacagtgt cctct                                                  735

<210> 239
<211> 735
<212> DNA
<213> Artificial Sequence

<220> 
<223> C1HL binder

<400> 239
caagttcagc tggttgaatc tggcggcgga ctggttaagc ctggcggttc tctgagactg 60
agctgtgccg cctccggctt caccttcagc gactactaca tgagctggat cagacaggcc 120
cctggcaaag gcctggaatg ggtgtcctac atcagctcca gcggcagcac catctactac 180
gccgatagcg tgaagggcag attcaccatc agccgggaca acgccaagaa cagcctgtac 240
ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagacacgcc 300
cctcacaagc actacgactt ttggagcggc tactaccccg actattgggg ccagggaaca 360
ctggtcacag tgtcctctgg tggcggagga tctggcggag gtggaagcgg cggaggcgga 420
tctgacatcc agatgacaca gagccctagc agcctgtctg ccagcgtggg agacagagtg 480
accatcacct gtagagccag ccagagcatc agcagctacc tgaactggta tcagcagaag 540
cccggcaagg cccctaaact gctgatctat gccgccagct ctctgcagtc tggcgtgcca 600
tctagatttt ccggcagcgg ctctggcacc gacttcaccc tgaccatatc tagcctgcag 660
cctgaggatg ccgccaccta ctactgtcag cactacggca catttggcca gggcaccaag 720
gtggaaatca agaga                                                  735

<210> 240
<211> 493
<212> PRT
<213> Artificial Sequence

<220> 
<223> RJ155LH CAR (C1LH/CD8 TM/4-1BB/CD3zeta)

<400> 240
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser
            20                  25                  30          
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
        35                  40                  45              
Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys
    50                  55                  60                  
Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val
65                  70                  75                  80  
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
                85                  90                  95      
Ile Ser Ser Leu Gln Pro Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His
            100                 105                 110         
Tyr Gly Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln
    130                 135                 140                 
Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg
145                 150                 155                 160 
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr Tyr Met Ser
                165                 170                 175     
Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Tyr Ile
            180                 185                 190         
Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg
        195                 200                 205             
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met
    210                 215                 220                 
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg His
225                 230                 235                 240 
Ala Pro His Lys His Tyr Asp Phe Trp Ser Gly Tyr Tyr Pro Asp Tyr
                245                 250                 255     
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Thr Thr
            260                 265                 270         
Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln
        275                 280                 285             
Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala
    290                 295                 300                 
Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala
305                 310                 315                 320 
Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr
                325                 330                 335     
Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln
            340                 345                 350         
Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser
        355                 360                 365             
Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys
    370                 375                 380                 
Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln
385                 390                 395                 400 
Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu
                405                 410                 415     
Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg
            420                 425                 430         
Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met
        435                 440                 445             
Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly
    450                 455                 460                 
Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp
465                 470                 475                 480 
Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
                485                 490

<210> 241
<211> 1479
<212> DNA
<213> Artificial Sequence

<220> 
<223> RJ155LH CAR (C1LH/CD8 TM/4-1BB/CD3zeta)

<400> 241
atgcttctgc tcgtgacaag cctgctgctg tgcgagctgc cccaccctgc ctttctgctg 60
atccctgaca tccagatgac acagagccct agcagcctgt ctgccagcgt gggagacaga 120
gtgaccatca cctgtagagc cagccagagc atcagcagct acctgaactg gtatcagcag 180
aagcccggca aggcccctaa actgctgatc tatgccgcca gctctctgca gtctggcgtg 240
ccatctagat tttccggcag cggctctggc accgacttca ccctgaccat atctagcctg 300
cagcctgagg atgccgccac ctactactgt cagcactacg gcacatttgg ccagggcacc 360
aaggtggaaa tcaagagagg tggcggagga tctggcggag gtggaagcgg cggaggcgga 420
tctcaagttc agctggttga atctggcggc ggactggtta agcctggcgg ttctctgaga 480
ctgagctgtg ccgcctccgg cttcaccttc agcgactact acatgagctg gatcagacag 540
gcccctggca aaggcctgga atgggtgtcc tacatcagct ccagcggcag caccatctac 600
tacgccgata gcgtgaaggg cagattcacc atcagccggg acaacgccaa gaacagcctg 660
tacctgcaga tgaactccct gagagccgag gacaccgccg tgtactattg tgccagacac 720
gcccctcaca agcactacga cttttggagc ggctactacc ccgactattg gggccaggga 780
acactggtca cagtgtcctc tgcggccgca accactactc cggcacctag gccccccact 840
ccggcaccga ccattgcatc acaaccactg agtcttagac ctgaagcctg tcgacccgca 900
gctggggggg cagtccacac acggggattg gatttcgcct gcgatatata catttgggcg 960
ccactggcag gcacctgcgg ggtcctgctc ttgtcccttg tcatcaccct gtactgtaag 1020
agaggaagaa agaagttgtt gtatattttc aaacagccat tcatgaggcc ggtccagacc 1080
actcaggagg aggatggatg cagttgccgc tttccggaag aggaagaggg tgggtgtgaa 1140
ctccgagtta aattttctcg cagtgctgat gccccagcgt ataaacaggg tcagaaccaa 1200
ctgtataatg aactcaattt ggggaggcga gaggagtatg atgtattgga caagcggcgg 1260
gggcgggatc ctgaaatggg cggtaagcca aggcgcaaga atccacagga gggtttgtat 1320
aatgagttgc agaaggataa aatggcggaa gcgtattcag aaatcggaat gaagggagag 1380
cgccgcagag ggaaagggca tgatggcctc taccaaggtt tgtcaacagc gaccaaggat 1440
acctatgacg cacttcatat gcaagcactg ccccccagg                        1479

<210> 242
<211> 493
<212> PRT
<213> Artificial Sequence

<220> 
<223> RJ155HL CAR (C1HL/CD8 TM/4-1BB/CD3zeta)

<400> 242
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly
            20                  25                  30          
Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly
        35                  40                  45              
Phe Thr Phe Ser Asp Tyr Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly
    50                  55                  60                  
Lys Gly Leu Glu Trp Val Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile
65                  70                  75                  80  
Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
                85                  90                  95      
Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
            100                 105                 110         
Thr Ala Val Tyr Tyr Cys Ala Arg His Ala Pro His Lys His Tyr Asp
        115                 120                 125             
Phe Trp Ser Gly Tyr Tyr Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val
    130                 135                 140                 
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
145                 150                 155                 160 
Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala
                165                 170                 175     
Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile
            180                 185                 190         
Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
        195                 200                 205             
Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg
    210                 215                 220                 
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
225                 230                 235                 240 
Leu Gln Pro Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Tyr Gly Thr
                245                 250                 255     
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Ala Ala Ala Thr Thr
            260                 265                 270         
Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln
        275                 280                 285             
Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala
    290                 295                 300                 
Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala
305                 310                 315                 320 
Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr
                325                 330                 335     
Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln
            340                 345                 350         
Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser
        355                 360                 365             
Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys
    370                 375                 380                 
Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln
385                 390                 395                 400 
Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu
                405                 410                 415     
Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg
            420                 425                 430         
Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met
        435                 440                 445             
Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly
    450                 455                 460                 
Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp
465                 470                 475                 480 
Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
                485                 490

<210> 243
<211> 1479
<212> DNA
<213> Artificial Sequence

<220> 
<223> RJ155HL CAR (C1HL/CD8 TM/4-1BB/CD3zeta)

<400> 243
atgcttctgc tcgtgacaag cctgctgctg tgcgagctgc cccaccctgc ctttctgctg 60
atccctcaag ttcagctggt tgaatctggc ggcggactgg ttaagcctgg cggttctctg 120
agactgagct gtgccgcctc cggcttcacc ttcagcgact actacatgag ctggatcaga 180
caggcccctg gcaaaggcct ggaatgggtg tcctacatca gctccagcgg cagcaccatc 240
tactacgccg atagcgtgaa gggcagattc accatcagcc gggacaacgc caagaacagc 300
ctgtacctgc agatgaactc cctgagagcc gaggacaccg ccgtgtacta ttgtgccaga 360
cacgcccctc acaagcacta cgacttttgg agcggctact accccgacta ttggggccag 420
ggaacactgg tcacagtgtc ctctggtggc ggaggatctg gcggaggtgg aagcggcgga 480
ggcggatctg acatccagat gacacagagc cctagcagcc tgtctgccag cgtgggagac 540
agagtgacca tcacctgtag agccagccag agcatcagca gctacctgaa ctggtatcag 600
cagaagcccg gcaaggcccc taaactgctg atctatgccg ccagctctct gcagtctggc 660
gtgccatcta gattttccgg cagcggctct ggcaccgact tcaccctgac catatctagc 720
ctgcagcctg aggatgccgc cacctactac tgtcagcact acggcacatt tggccagggc 780
accaaggtgg aaatcaagag agcggccgca accactactc cggcacctag gccccccact 840
ccggcaccga ccattgcatc acaaccactg agtcttagac ctgaagcctg tcgacccgca 900
gctggggggg cagtccacac acggggattg gatttcgcct gcgatatata catttgggcg 960
ccactggcag gcacctgcgg ggtcctgctc ttgtcccttg tcatcaccct gtactgtaag 1020
agaggaagaa agaagttgtt gtatattttc aaacagccat tcatgaggcc ggtccagacc 1080
actcaggagg aggatggatg cagttgccgc tttccggaag aggaagaggg tgggtgtgaa 1140
ctccgagtta aattttctcg cagtgctgat gccccagcgt ataaacaggg tcagaaccaa 1200
ctgtataatg aactcaattt ggggaggcga gaggagtatg atgtattgga caagcggcgg 1260
gggcgggatc ctgaaatggg cggtaagcca aggcgcaaga atccacagga gggtttgtat 1320
aatgagttgc agaaggataa aatggcggaa gcgtattcag aaatcggaat gaagggagag 1380
cgccgcagag ggaaagggca tgatggcctc taccaaggtt tgtcaacagc gaccaaggat 1440
acctatgacg cacttcatat gcaagcactg ccccccagg                        1479

<210> 244
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary Linker Sequences for scFv's, CARs,
      and/or cell engagers

<400> 244
Gly Gly Gly Gly Ser Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser
 1               5                  10                  15

<210> 245
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary Linker Sequences for scFv's, CARs,
      and/or cell engagers

<400> 245
Gly Gly Gly Gly Ser Gly Gly Ser Gly Ser Ser Gly Gly Gly Ser
 1               5                  10                  15

<210> 246
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary Linker Sequences for scFv's, CARs,
      and/or cell engagers

<400> 246
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
 1               5                  10                  15

<210> 247
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary Linker Sequences for scFv's, CARs,
      and/or cell engagers

<400> 247
Gly Gly Gly Gly Ser Gly Ser Gly Ala Ser Ser Gly Gly Gly Ser
 1               5                  10                  15

<210> 248
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary Linker Sequences for scFv's, CARs,
      and/or cell engagers

<400> 248
Gly Gly Gly Gly Ser Gly Ser Gly Ala Ser Gly Gly Gly Gly Ser
 1               5                  10                  15

<210> 249
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary Linker Sequences for scFv's, CARs,
      and/or cell engagers

<400> 249
Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
 1               5                  10                  15

<210> 250
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary Linker Sequences for scFv's, CARs,
      and/or cell engagers

<400> 250
Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr
 1               5                  10                  15      
Lys Gly

<210> 251
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary Linker Sequences for scFv's, CARs,
      and/or cell engagers

<400> 251
Pro Asn Gly Ala Ser Gln Ser Ser Ser Ala Ser His Thr Gly Ser Ala
 1               5                  10                  15      
Pro Gly Ser

<210> 252
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary Linker Sequences for scFv's, CARs,
      and/or cell engagers

<400> 252
Pro Asn Gly Ala Ser Asn Ser Gly Ser Ala Pro Asp Thr Ser Ser Ala
 1               5                  10                  15      
Pro Gly Ser

<210> 253
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary Linker Sequences for scFv's, CARs,
      and/or cell engagers

<400> 253
Pro Asn Gly Ala Ser His Ser Gly Ser Ala Pro Asn Thr Ser Ser Ala
 1               5                  10                  15      
Pro Gly Ser

<210> 254
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary Linker Sequences for scFv's, CARs,
      and/or cell engagers

<400> 254
Pro Asn Gly Ala Ser Glu Ser Gly Ser Ala Ser Lys Thr Ser Ser Ala
 1               5                  10                  15      
Ser Gly Ser

<210> 255
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary Linker Sequences for scFv's, CARs,
      and/or cell engagers

<400> 255
Pro Asn Gly Ala Ser Asn Ser Gly Ser Ala Pro Lys Thr Gly Ser Ala
 1               5                  10                  15      
Ser Gly Ser

<210> 256
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary Linker Sequences for scFv's, CARs,
      and/or cell engagers

<400> 256
Pro Asn Gly Ala Ser Lys Ser Gly Ser Ala Ser Gln Thr Ser Ser Ala
 1               5                  10                  15      
Pro Gly Ser

<210> 257
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary Linker Sequences for scFv's, CARs,
      and/or cell engagers

<400> 257
Pro Asn Gly Ala Ser His Ser Ser Ser Ala Ser Gln Thr Gly Ser Ala
 1               5                  10                  15      
Pro Gly Ser

<210> 258
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary Linker Sequences for scFv's, CARs,
      and/or cell engagers

<400> 258
Pro Asn Gly Ala Ser Lys Arg Ser Ala Pro Gly Ser
 1               5                  10

<210> 259
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary Linker Sequences for scFv's, CARs,
      and/or cell engagers

<400> 259
Pro Asn Gly Ala Ser His Ser Gly Ser Ala Pro His Thr Ser Ser Ala
 1               5                  10                  15      
Ser Gly Ser

<210> 260
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary Linker Sequences for scFv's, CARs,
      and/or cell engagers

<400> 260
Arg Gly Arg Gly Arg Gly Arg Gly Arg Ser Arg Gly Gly Gly Ser
 1               5                  10                  15

<210> 261
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary Linker Sequences for scFv's, CARs,
      and/or cell engagers

<400> 261
Ser His Gly Gly Ser His Gly Gly Gly Ser Gly Gly Gly Gly Ser
 1               5                  10                  15

<210> 262
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary Linker Sequences for scFv's, CARs,
      and/or cell engagers

<400> 262
Gly Gln Ala Gly Arg
 1               5

<210> 263
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary Linker Sequences for scFv's, CARs,
      and/or cell engagers

<400> 263
Gly Gly Gly Ser Gly Gly Gly Gly
 1               5 

<210> 264
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary Linker Sequences for scFv's, CARs,
      and/or cell engagers

<400> 264
Ser Gly Gly Gly Gly
 1               5

<210> 265
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary Linker Sequences for scFv's, CARs,
      and/or cell engagers

<400> 265
Gly Gly Gly Gly Ser
 1               5

<210> 266
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary Linker Sequences for scFv's, CARs,
      and/or cell engagers

<400> 266
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
 1               5                  10                  15      
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
            20                  25                  30

<210> 267
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary human IgG1-derived hinge

<400> 267
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
 1               5                  10                  15

<210> 268
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary human IgG2-derived hinge

<400> 268
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala
 1               5                  10                  15

<210> 269
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary human IgG4-derived hinge

<400> 269
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro
 1               5                  10

<210> 270
<211> 49
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary human CD8alpha-derived hinges

<400> 270
Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr
 1               5                  10                  15      
Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala
            20                  25                  30          
Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile
        35                  40                  45              
Tyr

<210> 271
<211> 47
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary human CD8alpha-derived hinge

<400> 271
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala
 1               5                  10                  15      
Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly
            20                  25                  30          
Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr
        35                  40                  45

<210> 272
<211> 45
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary human CD8alpha-derived hinge

<400> 272
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala
 1               5                  10                  15      
Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly
            20                  25                  30          
Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp
        35                  40                  45

<210> 273
<211> 39
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary human CD28-derived hinge

<400> 273
Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Arg Ser Asn
 1               5                  10                  15      
Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu
            20                  25                  30          
Phe Pro Gly Pro Ser Lys Pro
        35

<210> 274
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary short hinges

<400> 274
Gly Gly Gly Gly Ser
 1               5

<210> 275
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary short hinge

<400> 275
Ala Ala Ala
 1

<210> 276
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary human CD3zeta transmembrane domain

<400> 276
Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu
 1               5                  10                  15      
Thr Ala Leu Phe Leu
            20

<210> 277
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary human CD4 transmembrane domain

<400> 277
Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile
 1               5                  10                  15      
Gly Leu Gly Ile Phe Phe
            20

<210> 278
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary human CD8alpha transmembrane domain

<400> 278
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu
 1               5                  10                  15      
Ser Leu Val Ile Thr
            20 

<210> 279
<211> 24
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary human CD8alpha transmembrane domain

<400> 279
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu
 1               5                  10                  15      
Ser Leu Val Ile Thr Leu Tyr Cys
            20

<210> 280
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary human CD8alpha transmembrane domain

<400> 280
Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu
 1               5                  10                  15      
Val Ile Thr Leu Tyr Cys
            20

<210> 281
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary human CD8alpha transmembrane domain

<400> 281
Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu
 1               5                  10                  15      
Val Ile Thr

<210> 282
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary human CD28 transmembrane domain

<400> 282
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu
 1               5                  10                  15      
Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val
            20                  25

<210> 283
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary human CD278 transmembrane domain

<400> 283
Phe Trp Leu Pro Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu
 1               5                  10                  15      
Gly Cys Ile Leu Ile
            20

<210> 284
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary human CD3? intracellular signaling
      domain

<400> 284
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly
 1               5                  10                  15      
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr
            20                  25                  30          
Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys
        35                  40                  45              
Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln
    50                  55                  60                  
Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu
65                  70                  75                  80  
Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr
                85                  90                  95      
Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro
            100                 105                 110         
Arg

<210> 285
<211> 42
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary human 4-1BB (CD137) intracellular
      signaling domain

<400> 285
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met
 1               5                  10                  15      
Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe
            20                  25                  30          
Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu
        35                  40

<210> 286
<211> 41
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary human CD28 intracellular signaling
      domain

<400> 286
Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr
 1               5                  10                  15      
Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro
            20                  25                  30          
Pro Arg Asp Phe Ala Ala Tyr Arg Ser
        35                  40

<210> 287
<211> 42
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary human OX40 (CD134) intracellular
      signaling domain

<400> 287
Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His
 1               5                  10                  15      
Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln
            20                  25                  30          
Ala Asp Ala His Ser Thr Leu Ala Lys Ile
        35                  40

<210> 288
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary human CD278 intracellular signaling
      domain

<400> 288
Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn
 1               5                  10                  15      
Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg
            20                  25                  30          
Leu Thr Asp Val Thr Leu
        35

<210> 289
<211> 24
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary human DAP10 intracellular signaling
      domain

<400> 289
Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys Val
 1               5                  10                  15      
Tyr Ile Asn Met Pro Gly Arg Gly
            20

<210> 290
<211> 52
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary human DAP12 intracellular signaling
      domain

<400> 290
Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala
 1               5                  10                  15      
Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu
            20                  25                  30          
Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg
        35                  40                  45              
Pro Tyr Tyr Lys
    50

<210> 291
<211> 48
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary human CD27 intracellular signaling
      domain

<400> 291
Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro
 1               5                  10                  15      
Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr
            20                  25                  30          
Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro
        35                  40                  45

<210> 292
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary anti-human CD3 scFv (clone OKT3) (Heavy
      chain)

<400> 292
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Val
    50                  55                  60                  
Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Phe
65                  70                  75                  80  
Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys
                85                  90                  95      
Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Pro Val Thr Val Ser Ser
        115

<210> 293
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary anti-human CD3 scFv (clone OKT3) (light
      chain)

<400> 293
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
            20                  25                  30          
Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr
        35                  40                  45              
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
    50                  55                  60                  
Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu
65                  70                  75                  80  
Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr Arg
            100                 105

<210> 294
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary anti-human CD3 scFv (clone UCHT1) (heavy
      chain)

<400> 294
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
            20                  25                  30          
Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Met
        35                  40                  45              
Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp
            100                 105                 110         
Gly Gln Gly Thr Thr Leu Thr Val Phe Ser
        115                 120

<210> 295
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary anti-human CD3 scFv (clone UCHT1) (light
      chain)

<400> 295
Met Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu
 1               5                  10                  15      
Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg Asn
            20                  25                  30          
Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu
        35                  40                  45              
Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Lys Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu
65                  70                  75                  80  
Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro
                85                  90                  95      
Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105

<210> 296
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary anti-human CD16a scFv (heavy chain)

<400> 296
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Phe Arg Cys Asp Arg Phe Arg Arg Phe Thr Ile Ser Arg Asp
65                  70                  75                  80  
Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu
                85                  90                  95      
Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Arg Ser Leu Leu Phe Asp
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Arg
        115                 120

<210> 297
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary anti-human CD16a scFv (light chain)

<400> 297
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln
 1               5                  10                  15      
Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala
            20                  25                  30          
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
        35                  40                  45              
Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser
    50                  55                  60                  
Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His
                85                  90                  95      
Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Gly
            100                 105

<210> 298
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary anti-human NKG2A scFv (Heavy chain)
      

<400> 298
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Glu Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg His Gly Asp Tyr Pro Arg Phe Phe Asp Val Trp Gly Gln Gly
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser
        115

<210> 299
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary anti-human NKG2A scFv (light chain)

<400> 299
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Ser Tyr
            20                  25                  30          
Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Leu Thr Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Gly Asn Pro Tyr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105

<210> 300
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary anti-human NKG2D scFv (Heavy chain)
      

<400> 300
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Phe Ile Arg Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Asp Arg Gly Leu Gly Asp Gly Thr Tyr Phe Asp Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Thr Val Thr Val Ser Ser
        115                 120

<210> 301
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary anti-human NKG2D scFv (light chain)

<400> 301
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
 1               5                  10                  15      
Ser Ile Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn
            20                  25                  30          
Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Phe Leu Ala Ile Ser Gly Leu Gln
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
                85                  90                  95      
Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105                 110

<210> 302
<211> 114
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary anti-human NKp30 scFv (heavy chain)

<400> 302
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly His Thr Phe Thr Ser Tyr
            20                  25                  30          
Phe Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Asn Pro Ser Asp Asp Tyr Ala Asn Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Thr Ala Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
            100                 105                 110         
Ser Ser

<210> 303
<211> 114
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary anti-human NKp30 scFv (heavy chain)

<400> 303
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly His Thr Phe Thr Ser Tyr
            20                  25                  30          
Phe Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Asn Pro Ser Asp Asp Tyr Ala Asn Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Thr Ala Ile Phe Asp Tyr Trp Gly Gln Gly Thr Pro Val Thr Val
            100                 105                 110         
Ser Ser

<210> 304
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary anti-human NKp30 scFv (light chain)

<400> 304
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 305
<211> 114
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary anti-human NKp46 scFv (Heavy chain)
      

<400> 305
Glu Ile Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Thr
            20                  25                  30          
Tyr Phe His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Asp Pro Lys Phe
    50                  55                  60                  
His Asp Lys Ala Thr Ile Ile Ala Asp Ile Ser Ser Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Phe Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ala Asn Arg Tyr Gly Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val
            100                 105                 110         
Ser Ser

<210> 306
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary anti-human NKp46 scFv (light chain)
      

<400> 306
Asp Ile Val Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly
 1               5                  10                  15      
Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Tyr Ile
            20                  25                  30          
Asn Gly Asn Thr His Leu Phe Trp Phe Leu Gln Arg Pro Gly Gln Ser
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His
                85                  90                  95      
Leu Glu Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile
            100                 105                 110

<210> 307
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary anti-human NKp46 scFv (Heavy chain)

<400> 307
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Val Ile Asn Trp Gly Lys Gln Arg Ser Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Glu Ile Tyr Pro Gly Ser Gly Thr Asn Tyr Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Ala Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Ile Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                85                  90                  95      
Ala Arg Arg Gly Arg Tyr Gly Leu Tyr Ala Met Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Ser Val Thr Val Ser Ser
        115                 120

<210> 308
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary anti-human NKp46 scFv (light chain)

<400> 308
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Val Ile Asn Trp Gly Lys Gln Arg Ser Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Glu Ile Tyr Pro Gly Ser Gly Thr Asn Tyr Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Ala Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Ile Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                85                  90                  95      
Ala Arg Arg Gly Arg Tyr Gly Leu Tyr Ala Met Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Ser Val Thr Val Ser Ser
        115                 120

<210> 309
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary anti-human CD16a VH domain

<400> 309
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Leu Val Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Ala
                85                  90                  95      
Arg Glu Ser Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
            100                 105                 110         
Ser

<210> 310
<211> 271
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker + gOKT3-7 (anti-CD3 scFv)

<400> 310
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln
 1               5                  10                  15      
Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser
            20                  25                  30          
Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr
        35                  40                  45              
Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly
    50                  55                  60                  
Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Val Lys
65                  70                  75                  80  
Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Phe Leu
                85                  90                  95      
Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala
            100                 105                 110         
Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr
        115                 120                 125             
Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
    130                 135                 140                 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
145                 150                 155                 160 
Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser
                165                 170                 175     
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser
            180                 185                 190         
Val Ser Tyr Met Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys
        195                 200                 205             
Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg
    210                 215                 220                 
Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser
225                 230                 235                 240 
Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser
                245                 250                 255     
Asn Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr Arg
            260                 265                 270

<210> 311
<211> 813
<212> DNA
<213> Artificial Sequence

<220> 
<223> Linker + gOKT3-7 (anti-CD3 scFv)

<400> 311
ggaggtggcg ggtctggtgg aggcggaagc ggtggtggcg gatcccaggt ccaactggtg 60
caaagtggag gcggcgtagt acagcccggt cggtccctgc ggctcagctg taaagcaagt 120
gggtacactt tcaccagata tacaatgcac tgggttagac aggcccccgg caagggtctt 180
gaatggatag gatatatcaa cccatcccgc ggatatacaa actacaatca gaaggtgaag 240
gaccggttca cgattagtag agacaactcc aaaaacactg cgttccttca aatggactca 300
ttgcgacccg aggacactgg agtgtatttc tgtgccaggt attatgacga ccattattgc 360
ctggactact gggggcaagg cacaccggtt acggtatctt ccggaggtgg cgggtctggt 420
ggaggcggaa gcggtggtgg cggatccggg ggaggaggct ctggcggagg cggatcaggg 480
ggtggaggtt ccgacattca aatgacacaa tcccctagtt ctttgtctgc gtccgtgggg 540
gatcgggtaa caatcacttg ctctgcatca agcagtgttt cttatatgaa ctggtatcag 600
cagacacccg gtaaggcccc aaaacgatgg atttatgaca cgagtaaact cgcatccggg 660
gtgccttcac gcttctccgg ttctggttcc ggcacggatt acactttcac catcagtagc 720
ctgcaacctg aggacattgc aacttattac tgtcaacaat ggagcagtaa tccattcacg 780
ttcggccaag ggacaaaact gcagattact agg                              813
