                         SEQUENCE LISTING

<110>  The Broad Institute, Inc.
       Massachusetts Institute of Technology
 
<120>  Helitron-Mediated Genetic Modification

<130>  BROD-5285WP

<150>  US 63/089,909
<151>  2020-10-09

<150>  US 63/133,993
<151>  2021-01-05

<160>  173   

<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  2
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Gly Gly Gly Ser 
1               


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Gly Gly Gly Gly Ser 
1               5   


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   


<210>  5
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  6
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  7
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  8
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210>  9
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser 
        35  


<210>  10
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40  


<210>  11
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40                  45  


<210>  12
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser 
    50  


<210>  13
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser 
    50                  55  


<210>  14
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    50                  55                  60  


<210>  15
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Leu Glu Pro Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser 
1               5                   10                  15      


Phe Ser Gln Ser Gly Ala Leu Thr Arg His Gln Arg Thr His Thr Arg 
            20                  25                  30          


<210>  16
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Ser Pro Lys Lys Arg Lys 
1               5                   10                  15      


Val Glu Ala Ser 
            20  


<210>  17
<211>  401
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17

Met Ser Thr Asp Ala Thr Leu Ile Arg Thr Thr Pro Ser His Ala Glu 
1               5                   10                  15      


Ala Asp Ala Thr Asp Thr Leu Val Ala Thr Pro Leu Met Pro Pro Arg 
            20                  25                  30          


Arg Val Ile Ser Pro Trp Pro Gly Pro Gly Glu Gly Gln Ser Leu Met 
        35                  40                  45              


Arg Ile Pro Val Val Asp Ile Arg Gly Met Ala Leu Met Pro Cys Thr 
    50                  55                  60                  


Pro Ala Lys Ala Arg His Leu Leu Lys Ser Gly Asn Ala Arg Pro Lys 
65                  70                  75                  80  


Arg Asn Lys Leu Gly Leu Phe Tyr Val Gln Leu Ser Tyr Glu Gln Glu 
                85                  90                  95      


Pro Asp Asn Gln Ser Leu Val Ala Gly Val Asp Pro Gly Ser Lys Phe 
            100                 105                 110         


Glu Gly Leu Ser Val Val Gly Thr Lys Asp Thr Val Leu Asn Leu Met 
        115                 120                 125             


Val Glu Ala Pro Asp His Val Lys Gly Ala Val Gln Thr Arg Arg Thr 
    130                 135                 140                 


Met Arg Arg Ala Arg Arg Gln Arg Lys Trp Arg Arg Pro Lys Arg Phe 
145                 150                 155                 160 


His Asn Arg Leu Asn Arg Met Gln Arg Ile Pro Pro Ser Thr Arg Ser 
                165                 170                 175     


Arg Trp Glu Ala Lys Ala Arg Ile Val Ala His Leu Arg Thr Ile Leu 
            180                 185                 190         


Pro Phe Thr Asp Val Val Val Glu Asp Val Gln Ala Val Thr Arg Lys 
        195                 200                 205             


Gly Lys Gly Gly Thr Trp Asn Gly Ser Phe Ser Pro Val Gln Val Gly 
    210                 215                 220                 


Lys Glu His Leu Tyr Arg Leu Leu Arg Ala Met Gly Leu Thr Leu His 
225                 230                 235                 240 


Leu Arg Glu Gly Trp Gln Thr Lys Glu Leu Arg Glu Gln His Gly Leu 
                245                 250                 255     


Lys Lys Thr Lys Ser Lys Ser Lys Gln Ser Phe Glu Ser His Ala Val 
            260                 265                 270         


Asp Ser Trp Val Leu Ala Ala Ser Ile Ser Gly Ala Glu His Pro Thr 
        275                 280                 285             


Cys Thr Arg Leu Trp Tyr Met Val Pro Ala Ile Leu His Arg Arg Gln 
    290                 295                 300                 


Leu His Arg Leu Gln Ala Ser Lys Gly Gly Val Arg Lys Pro Tyr Gly 
305                 310                 315                 320 


Gly Thr Arg Ser Leu Gly Val Lys Arg Gly Thr Leu Val Glu His Lys 
                325                 330                 335     


Lys Tyr Gly Arg Cys Thr Val Gly Gly Val Asp Arg Lys Arg Asn Thr 
            340                 345                 350         


Ile Ser Leu His Glu Tyr Arg Thr Asn Thr Arg Leu Thr Gln Ala Ala 
        355                 360                 365             


Lys Val Glu Thr Cys Arg Val Leu Thr Trp Leu Ser Trp Arg Ser Trp 
    370                 375                 380                 


Leu Leu Arg Gly Lys Arg Thr Ser Ser Lys Gly Lys Gly Ser His Ser 
385                 390                 395                 400 


Ser 
    


<210>  18
<211>  432
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Met Gln Pro Ala Lys Gln Gln Asn Trp Val Phe Gln Ile Asn Gly Asp 
1               5                   10                  15      


Lys Gln Pro Leu Asp Met Ile Asn Pro Gly Arg Cys Arg Glu Leu Gln 
            20                  25                  30          


Asn Arg Gly Lys Leu Ala Ser Phe Arg Arg Phe Pro Tyr Val Val Ile 
        35                  40                  45              


Gln Gln Gln Thr Ile Glu Asn Pro Gln Thr Lys Glu Tyr Ile Leu Lys 
    50                  55                  60                  


Ile Asp Pro Gly Ser Gln Trp Thr Gly Phe Ala Ile Gln Cys Gly Asn 
65                  70                  75                  80  


Asp Ile Leu Phe Arg Ala Glu Leu Asn His Arg Gly Glu Ala Ile Lys 
                85                  90                  95      


Phe Asp Leu Val Lys Arg Ala Trp Phe Arg Arg Gly Arg Arg Ser Arg 
            100                 105                 110         


Asn Leu Arg Tyr Arg Lys Lys Arg Leu Asn Arg Ala Lys Pro Glu Gly 
        115                 120                 125             


Trp Leu Ala Pro Ser Ile Arg His Arg Val Leu Thr Val Glu Thr Trp 
    130                 135                 140                 


Ile Lys Arg Phe Met Arg Tyr Cys Pro Ile Ala Trp Ile Glu Ile Glu 
145                 150                 155                 160 


Gln Val Arg Phe Asp Thr Gln Lys Leu Ala Asn Pro Glu Ile Asp Gly 
                165                 170                 175     


Val Glu Tyr Gln Gln Gly Glu Leu Gln Gly Tyr Glu Val Arg Glu Tyr 
            180                 185                 190         


Leu Leu Gln Lys Trp Gly Arg Lys Cys Ala Tyr Cys Gly Thr Glu Asn 
        195                 200                 205             


Val Pro Leu Glu Val Glu His Ile Gln Ser Lys Ser Lys Gly Gly Ser 
    210                 215                 220                 


Ser Arg Ile Gly Asn Leu Thr Leu Ala Cys His Val Cys Asn Val Lys 
225                 230                 235                 240 


Lys Gly Asn Leu Asp Val Arg Asp Phe Leu Ala Lys Ser Pro Asp Ile 
                245                 250                 255     


Leu Asn Gln Val Leu Glu Asn Ser Thr Lys Pro Leu Lys Asp Ala Ala 
            260                 265                 270         


Ala Val Asn Ser Thr Arg Tyr Ala Ile Val Lys Met Ala Lys Ser Ile 
        275                 280                 285             


Cys Glu Asn Val Lys Cys Ser Ser Gly Ala Arg Thr Lys Met Asn Arg 
    290                 295                 300                 


Val Arg Gln Gly Leu Glu Lys Thr His Ser Leu Asp Ala Ala Cys Val 
305                 310                 315                 320 


Gly Glu Ser Gly Ala Ser Ile Arg Val Leu Thr Asp Arg Pro Leu Leu 
                325                 330                 335     


Ile Thr Cys Lys Gly His Gly Ser Arg Gln Ser Ile Arg Val Asn Ala 
            340                 345                 350         


Ser Gly Phe Pro Ala Val Lys Asn Ala Lys Thr Val Phe Thr His Ile 
        355                 360                 365             


Ala Ala Gly Asp Val Val Arg Phe Thr Ile Gly Lys Asp Arg Lys Lys 
    370                 375                 380                 


Ala Gln Ala Gly Thr Tyr Thr Ala Arg Val Lys Thr Pro Thr Pro Lys 
385                 390                 395                 400 


Gly Phe Glu Val Leu Ile Asp Gly Ala Arg Ile Ser Leu Ser Thr Met 
                405                 410                 415     


Ser Asn Val Val Phe Val His Arg Ser Asp Gly Tyr Gly Tyr Glu Leu 
            420                 425                 430         


<210>  19
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19

Met Ala Val Phe Val Ile Asp Lys His Lys Arg Pro Leu Met Pro Cys 
1               5                   10                  15      


Ser Glu Lys Arg Ala Arg Leu Leu Leu Glu Arg Gly Arg Ala Val Val 
            20                  25                  30          


His Arg Gln Val Pro Phe Val Ile Arg Leu Lys Asp Arg Thr Val Gln 
        35                  40                  45              


His Ser Ala Val Gln Pro Leu Arg Val Ala Leu Asp Pro Gly Ser Arg 
    50                  55                  60                  


Ala Thr Gly Met Ala Leu Val Arg Glu Lys Asn Thr Val Asp Thr Gly 
65                  70                  75                  80  


Thr Gly Glu Val Tyr Arg Glu Arg Ile Ala Leu Asn Leu Phe Glu Leu 
                85                  90                  95      


Val His Arg Gly His Arg Ile Arg Glu Gln Leu Asp Gln Arg Arg Asn 
            100                 105                 110         


Phe Arg Arg Arg Arg Arg Gly Ala Asn Leu Arg Tyr Arg Ala Pro Arg 
        115                 120                 125             


Phe Asp Asn Arg Arg Arg Pro Pro Gly Trp Leu Ala Pro Ser Leu Gln 
    130                 135                 140                 


His Arg Val Asp Thr Thr Met Ala Trp Val Arg Arg Leu Cys Arg Trp 
145                 150                 155                 160 


Ala Pro Ala Ser Ala Ile Gly Ile Glu Thr Val Arg Phe Asp Thr Gln 
                165                 170                 175     


Arg Leu Gln Asn Pro Glu Ile Ser Gly Val Glu Tyr Gln Gln Gly Ala 
            180                 185                 190         


Leu Ala Gly Cys Glu Val Arg Glu Tyr Leu Leu Glu Lys Trp Gly Arg 
        195                 200                 205             


Lys Cys Ala Tyr Cys Gly Ala Glu Asn Val Pro Leu Glu Ile Glu His 
    210                 215                 220                 


Ile Val Pro Lys Ser Arg Gly Gly Ser Asp Arg Val Ser Asn Leu Ala 
225                 230                 235                 240 


Leu Ala Cys Arg Ala Cys Asn Gln Ala Lys Gly Asn Arg Asp Val Arg 
                245                 250                 255     


Ala Phe Leu Ala Asp Gln Pro Glu Arg Leu Ala Arg Ile Leu Ala Gln 
            260                 265                 270         


Ala Lys Ala Pro Leu Lys Asp Ala Ala Ala Val Asn Ala Thr Arg Trp 
        275                 280                 285             


Ala Leu Tyr Arg Ala Leu Val Asp Thr Gly Leu Pro Val Glu Ala Gly 
    290                 295                 300                 


Thr Gly Gly Arg Thr Lys Trp Asn Arg Thr Arg Leu Gly Leu Pro Lys 
305                 310                 315                 320 


Thr His Ala Leu Asp Ala Leu Cys Val Gly Gln Val Asp Gln Val Arg 
                325                 330                 335     


His Trp Arg Val Pro Val Leu Gly Ile Arg Cys Ala Gly Arg Gly Ser 
            340                 345                 350         


Tyr Arg Arg Thr Arg Leu Thr Arg His Gly Phe Pro Arg Gly Tyr Leu 
        355                 360                 365             


Thr Arg Asn Lys Ser Ala Phe Gly Phe Gln Thr Gly Asp Leu Ile Arg 
    370                 375                 380                 


Ala Val Val Thr Lys Gly Lys Lys Ala Gly Thr Tyr Leu Gly Arg Ile 
385                 390                 395                 400 


Ala Ile Arg Ala Ser Gly Ser Phe Asn Ile Gln Thr Pro Met Gly Val 
                405                 410                 415     


Val Gln Gly Ile His His Arg Phe Cys Thr Leu Leu Gln Arg Ala Asp 
            420                 425                 430         


Gly Tyr Gly Tyr Phe Val Gln Pro Lys Pro Thr Glu Ala Ala Leu Ser 
        435                 440                 445             


Ser Pro Arg Leu Lys Ala Gly Val Ser Ser Ala Gly Asn 
    450                 455                 460     


<210>  20
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20

Met Thr Thr Asn Val Val Phe Val Ile Asp Thr Asn Gln Lys Pro Leu 
1               5                   10                  15      


Gln Pro Cys Ser Ala Ala Val Ala Arg Lys Leu Leu Leu Arg Gly Lys 
            20                  25                  30          


Ala Ala Met Phe Arg Arg Tyr Pro Ala Val Ile Ile Leu Lys Lys Glu 
        35                  40                  45              


Val Asp Ser Val Gly Lys Pro Lys Ile Glu Leu Arg Ile Asp Pro Gly 
    50                  55                  60                  


Ser Lys Tyr Thr Gly Phe Ala Leu Val Asp Ser Lys Asp Asn Ala Asp 
65                  70                  75                  80  


Phe Ile Ile Trp Gly Thr Glu Leu Glu His Arg Gly Ala Ala Ile Cys 
                85                  90                  95      


Lys Glu Leu Thr Lys Arg Ser Ala Ile Arg Arg Ser Arg Arg Asn Arg 
            100                 105                 110         


Lys Thr Arg Tyr Arg Lys Lys Arg Phe Glu Arg Arg Lys Pro Glu Gly 
        115                 120                 125             


Trp Leu Ala Pro Ser Leu Gln His Arg Val Asp Thr Thr Leu Thr Trp 
    130                 135                 140                 


Val Lys Arg Ile Cys Lys Phe Val Pro Ile Met Ser Ile Ser Val Glu 
145                 150                 155                 160 


Gln Val Lys Phe Asp Leu Gln Lys Leu Glu Asn Ser Asp Ile Gln Gly 
                165                 170                 175     


Ile Glu Tyr Gln Gln Gly Thr Leu Ala Gly Tyr Thr Leu Arg Glu Ala 
            180                 185                 190         


Leu Leu Glu His Trp Gly Arg Lys Cys Ala Tyr Cys Asp Val Glu Asn 
        195                 200                 205             


Val Phe Leu Glu Ile Glu His Ile Tyr Pro Lys Ser Lys Gly Gly Ser 
    210                 215                 220                 


Asp Lys Phe Ser Asn Leu Thr Leu Ala Cys His Lys Cys Asn Ile Asn 
225                 230                 235                 240 


Lys Gly Asn Lys Ser Ile Asp Glu Phe Leu Leu Ser Asp His Lys Arg 
                245                 250                 255     


Leu Glu Gln Ile Lys Leu His Gln Lys Lys Thr Leu Lys Asp Ala Ala 
            260                 265                 270         


Ala Val Asn Ala Thr Arg Lys Lys Leu Val Thr Thr Leu Gln Glu Lys 
        275                 280                 285             


Thr Phe Leu Asn Val Leu Val Ser Asp Gly Ala Ser Thr Lys Met Thr 
    290                 295                 300                 


Arg Leu Ser Ser Ser Leu Ala Lys Arg His Trp Ile Asp Ala Gly Cys 
305                 310                 315                 320 


Val Asn Thr Thr Leu Ile Val Ile Leu Lys Thr Leu Gln Pro Leu Gln 
                325                 330                 335     


Val Lys Cys Asn Gly His Gly Asn Lys Gln Phe Val Thr Met Asp Ala 
            340                 345                 350         


Tyr Gly Phe Pro Arg Lys Ser Tyr Glu Pro Lys Lys Val Arg Lys Asp 
        355                 360                 365             


Trp Lys Ala Gly Asp Ile Ile Arg Val Thr Lys Lys Asp Gly Thr Met 
    370                 375                 380                 


Leu Met Gly Arg Val Lys Lys Ala Ala Lys Lys Leu Val Tyr Ile Pro 
385                 390                 395                 400 


Phe Gly Gly Lys Glu Ala Ser Phe Ser Ser Glu Asn Ala Lys Ala Ile 
                405                 410                 415     


His Arg Ser Asp Gly Tyr Arg Tyr Ser Phe Ala Ala Ile Asp Ser Glu 
            420                 425                 430         


Leu Leu Gln Lys Met Ala Thr 
        435                 


<210>  21
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21

Met Pro Asn Lys Tyr Ala Phe Val Leu Asp Ser Lys Gly Lys Leu Leu 
1               5                   10                  15      


Asp Pro Thr Lys Ser Lys Lys Ala Trp Tyr Leu Ile Arg Lys Gly Lys 
            20                  25                  30          


Ala Ser Leu Val Glu Glu Tyr Pro Leu Ile Ile Lys Leu Lys Arg Glu 
        35                  40                  45              


Val Pro Lys Asp Gln Val Asn Ser Asp Lys Leu Ile Leu Gly Ile Asp 
    50                  55                  60                  


Asp Gly Thr Lys Lys Val Gly Phe Ala Leu Val Gln Lys Cys Gln Thr 
65                  70                  75                  80  


Lys Asn Lys Val Leu Phe Lys Ala Val Met Glu Gln Arg Gln Asp Val 
                85                  90                  95      


Ser Lys Lys Met Glu Glu Arg Arg Gly Tyr Arg Arg Tyr Arg Arg Ser 
            100                 105                 110         


His Lys Arg Tyr Arg Pro Ala Arg Phe Asp Asn Arg Ser Ser Ser Lys 
        115                 120                 125             


Arg Lys Gly Arg Ile Pro Pro Ser Ile Leu Gln Lys Lys Gln Ala Ile 
    130                 135                 140                 


Leu Arg Val Val Asn Lys Leu Lys Lys Tyr Ile Arg Ile Asp Lys Ile 
145                 150                 155                 160 


Val Leu Glu Asp Val Ser Ile Asp Ile Arg Lys Leu Thr Glu Gly Arg 
                165                 170                 175     


Glu Leu Tyr Asn Trp Glu Tyr Gln Glu Ser Asn Arg Leu Asp Glu Asn 
            180                 185                 190         


Leu Arg Lys Ala Thr Leu Tyr Arg Asp Asp Cys Thr Cys Gln Leu Cys 
        195                 200                 205             


Gly Thr Thr Glu Thr Met Leu His Ala His His Ile Met Pro Arg Arg 
    210                 215                 220                 


Asp Gly Gly Ala Asp Ser Ile Tyr Asn Leu Ile Thr Leu Cys Lys Ala 
225                 230                 235                 240 


Cys His Lys Asp Lys Val Asp Asn Asn Glu Tyr Gln Tyr Lys Asp Gln 
                245                 250                 255     


Phe Leu Ala Ile Ile Asp Ser Lys Glu Leu Ser Asp Leu Lys Ser Ala 
            260                 265                 270         


Ser His Val Met Gln Gly Lys Thr Trp Leu Arg Asp Lys Leu Ser Lys 
        275                 280                 285             


Ile Ala Gln Leu Glu Ile Thr Ser Gly Gly Asn Thr Ala Asn Lys Arg 
    290                 295                 300                 


Ile Asp Tyr Glu Ile Glu Lys Ser His Ser Asn Asp Ala Ile Cys Thr 
305                 310                 315                 320 


Thr Gly Leu Leu Pro Val Asp Asn Ile Asp Asp Ile Lys Glu Tyr Tyr 
                325                 330                 335     


Ile Lys Pro Leu Arg Lys Lys Ser Lys Ala Lys Ile Lys Glu Leu Lys 
            340                 345                 350         


Cys Phe Arg Gln Arg Asp Leu Val Lys Tyr Thr Lys Arg Asn Gly Glu 
        355                 360                 365             


Thr Tyr Thr Gly Tyr Ile Thr Ser Leu Arg Ile Lys Asn Asn Lys Tyr 
    370                 375                 380                 


Asn Ser Lys Val Cys Asn Phe Ser Thr Leu Lys Gly Lys Ile Phe Arg 
385                 390                 395                 400 


Gly Tyr Gly Phe Arg Asn Leu Thr Leu Leu Asn Arg Pro Lys Gly Leu 
                405                 410                 415     


Met Ile Val 
            


<210>  22
<211>  1409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22

Met Leu Phe Asn Lys Cys Ile Ile Ile Ser Ile Asn Leu Asp Phe Ser 
1               5                   10                  15      


Asn Lys Glu Lys Cys Met Thr Lys Pro Tyr Ser Ile Gly Leu Asp Ile 
            20                  25                  30          


Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Asn Tyr Lys Val 
        35                  40                  45              


Pro Ser Lys Lys Met Lys Val Leu Gly Asn Thr Ser Lys Lys Tyr Ile 
    50                  55                  60                  


Lys Lys Asn Leu Leu Gly Val Leu Leu Phe Asp Ser Gly Ile Thr Ala 
65                  70                  75                  80  


Glu Gly Arg Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg 
                85                  90                  95      


Arg Asn Arg Ile Leu Tyr Leu Gln Glu Ile Phe Ser Thr Glu Met Ala 
            100                 105                 110         


Thr Leu Asp Asp Ala Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val 
        115                 120                 125             


Pro Asp Asp Lys Arg Asp Ser Lys Tyr Pro Ile Phe Gly Asn Leu Val 
    130                 135                 140                 


Glu Glu Lys Val Tyr His Asp Glu Phe Pro Thr Ile Tyr His Leu Arg 
145                 150                 155                 160 


Lys Tyr Leu Ala Asp Ser Thr Lys Lys Ala Asp Leu Arg Leu Val Tyr 
                165                 170                 175     


Leu Ala Leu Ala His Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu 
            180                 185                 190         


Gly Glu Phe Asn Ser Lys Asn Asn Asp Ile Gln Lys Asn Phe Gln Asp 
        195                 200                 205             


Phe Leu Asp Thr Tyr Asn Ala Ile Phe Glu Ser Asp Leu Ser Leu Glu 
    210                 215                 220                 


Asn Ser Lys Gln Leu Glu Glu Ile Val Lys Asp Lys Ile Ser Lys Leu 
225                 230                 235                 240 


Glu Lys Lys Asp Arg Ile Leu Lys Leu Phe Pro Gly Glu Lys Asn Ser 
                245                 250                 255     


Gly Ile Phe Ser Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp 
            260                 265                 270         


Phe Arg Lys Cys Phe Asn Leu Asp Glu Lys Ala Ser Leu His Phe Ser 
        275                 280                 285             


Lys Glu Ser Tyr Asp Glu Asp Leu Glu Thr Leu Leu Gly Tyr Ile Gly 
    290                 295                 300                 


Asp Asp Tyr Ser Asp Val Phe Leu Lys Ala Lys Lys Leu Tyr Asp Ala 
305                 310                 315                 320 


Ile Leu Leu Ser Gly Phe Leu Thr Val Thr Asp Asn Glu Thr Glu Ala 
                325                 330                 335     


Pro Leu Ser Ser Ala Met Ile Lys Arg Tyr Asn Glu His Lys Glu Asp 
            340                 345                 350         


Leu Ala Leu Leu Lys Glu Tyr Ile Arg Asn Ile Ser Leu Lys Thr Tyr 
        355                 360                 365             


Asn Glu Val Phe Lys Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Ile 
    370                 375                 380                 


Asp Gly Lys Thr Asn Gln Glu Asp Phe Tyr Val Tyr Leu Lys Asn Leu 
385                 390                 395                 400 


Leu Ala Glu Phe Glu Gly Ala Asp Tyr Phe Leu Glu Lys Ile Asp Arg 
                405                 410                 415     


Glu Asp Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro 
            420                 425                 430         


Tyr Gln Ile His Leu Gln Glu Met Arg Ala Ile Leu Asp Lys Gln Ala 
        435                 440                 445             


Lys Phe Tyr Pro Phe Leu Ala Lys Asn Lys Glu Arg Ile Glu Lys Ile 
    450                 455                 460                 


Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn 
465                 470                 475                 480 


Ser Asp Phe Ala Trp Ser Ile Arg Lys Arg Asn Glu Lys Ile Thr Pro 
                485                 490                 495     


Trp Asn Phe Glu Asp Val Ile Asp Lys Glu Ser Ser Ala Glu Ala Phe 
            500                 505                 510         


Ile Asn Arg Met Thr Ser Phe Asp Leu Tyr Leu Pro Glu Glu Lys Val 
        515                 520                 525             


Leu Pro Lys His Ser Leu Leu Tyr Glu Thr Phe Asn Val Tyr Asn Glu 
    530                 535                 540                 


Leu Thr Lys Val Arg Phe Ile Ala Glu Ser Met Arg Asp Tyr Gln Phe 
545                 550                 555                 560 


Leu Asp Ser Lys Gln Lys Lys Asp Ile Val Arg Leu Tyr Phe Lys Asp 
                565                 570                 575     


Lys Arg Lys Val Thr Asp Lys Asp Ile Ile Glu Tyr Leu His Ala Ile 
            580                 585                 590         


Tyr Gly Tyr Asp Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn 
        595                 600                 605             


Ser Ser Leu Ser Thr Tyr His Asp Leu Leu Asn Ile Ile Asn Asp Lys 
    610                 615                 620                 


Glu Phe Leu Asp Asp Ser Ser Asn Glu Ala Ile Ile Glu Glu Ile Ile 
625                 630                 635                 640 


His Thr Leu Thr Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu 
                645                 650                 655     


Ser Lys Phe Glu Asn Ile Phe Asp Lys Ser Val Leu Lys Lys Leu Ser 
            660                 665                 670         


Arg Arg His Tyr Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn 
        675                 680                 685             


Gly Ile Arg Asp Glu Lys Ser Gly Asn Thr Ile Leu Asp Tyr Leu Ile 
    690                 695                 700                 


Asp Asp Gly Ile Ser Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
705                 710                 715                 720 


Ala Leu Ser Phe Lys Lys Lys Ile Gln Lys Ala Gln Ile Ile Gly Asp 
                725                 730                 735     


Glu Asp Lys Gly Asn Ile Lys Glu Val Val Lys Ser Leu Pro Gly Ser 
            740                 745                 750         


Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser Ile Lys Ile Val Asp Glu 
        755                 760                 765             


Leu Val Lys Val Met Gly Gly Arg Lys Pro Glu Ser Ile Val Val Glu 
    770                 775                 780                 


Met Ala Arg Glu Asn Gln Tyr Thr Asn Gln Gly Lys Ser Asn Ser Gln 
785                 790                 795                 800 


Gln Arg Leu Lys Arg Leu Glu Lys Ser Leu Lys Glu Leu Gly Ser Lys 
                805                 810                 815     


Ile Leu Lys Glu Asn Ile Pro Ala Lys Leu Ser Lys Ile Asp Asn Asn 
            820                 825                 830         


Ala Leu Gln Asn Asp Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Lys 
        835                 840                 845             


Asp Met Tyr Thr Gly Asp Asp Leu Asp Ile Asp Arg Leu Ser Asn Tyr 
    850                 855                 860                 


Asp Ile Asp His Ile Ile Pro Gln Ala Phe Leu Lys Asp Asn Ser Ile 
865                 870                 875                 880 


Asp Asn Lys Val Leu Val Ser Ser Ala Ser Asn Arg Gly Lys Ser Asp 
                885                 890                 895     


Asp Phe Pro Ser Leu Glu Val Val Lys Lys Arg Lys Thr Phe Trp Tyr 
            900                 905                 910         


Gln Leu Leu Lys Ser Lys Leu Ile Ser Gln Arg Lys Phe Asp Asn Leu 
        915                 920                 925             


Thr Lys Ala Glu Arg Gly Gly Leu Leu Pro Glu Asp Lys Ala Gly Phe 
    930                 935                 940                 


Ile Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala 
945                 950                 955                 960 


Arg Leu Leu Asp Glu Lys Phe Asn Asn Lys Lys Asp Glu Asn Asn Arg 
                965                 970                 975     


Ala Val Arg Thr Val Lys Ile Ile Thr Leu Lys Ser Thr Leu Val Ser 
            980                 985                 990         


Gln Phe Arg Lys Asp Phe Glu Leu  Tyr Lys Val Arg Glu  Ile Asn Asp 
        995                 1000                 1005             


Phe His  His Ala His Asp Ala  Tyr Leu Asn Ala Val  Ile Ala Ser 
    1010                 1015                 1020             


Ala Leu  Leu Lys Lys Tyr Pro  Lys Leu Glu Pro Glu  Phe Val Tyr 
    1025                 1030                 1035             


Gly Asp  Tyr Pro Lys Tyr Asn  Ser Phe Arg Glu Arg  Lys Ser Ala 
    1040                 1045                 1050             


Thr Glu  Lys Val Tyr Phe Tyr  Ser Asn Ile Met Asn  Ile Phe Lys 
    1055                 1060                 1065             


Lys Ser  Ile Ser Leu Ala Asp  Gly Arg Val Ile Glu  Arg Pro Leu 
    1070                 1075                 1080             


Ile Glu  Val Asn Glu Glu Thr  Gly Glu Ser Val Trp  Asn Lys Glu 
    1085                 1090                 1095             


Ser Asp  Leu Ala Thr Val Arg  Arg Val Leu Ser Tyr  Pro Gln Val 
    1100                 1105                 1110             


Asn Val  Val Lys Lys Val Glu  Glu Gln Asn His Gly  Leu Asp Arg 
    1115                 1120                 1125             


Gly Lys  Pro Lys Gly Leu Phe  Asn Ala Asn Leu Ser  Ser Lys Pro 
    1130                 1135                 1140             


Lys Pro  Asn Ser Asn Glu Asn  Leu Val Gly Ala Lys  Glu Tyr Leu 
    1145                 1150                 1155             


Asp Pro  Lys Lys Tyr Gly Gly  Tyr Ala Gly Ile Ser  Asn Ser Phe 
    1160                 1165                 1170             


Ala Val  Leu Val Lys Gly Thr  Ile Glu Lys Gly Ala  Lys Lys Lys 
    1175                 1180                 1185             


Ile Thr  Asn Val Leu Glu Phe  Gln Gly Ile Ser Ile  Leu Asp Arg 
    1190                 1195                 1200             


Ile Asn  Tyr Arg Lys Asp Lys  Leu Asn Phe Leu Leu  Glu Lys Gly 
    1205                 1210                 1215             


Tyr Lys  Asp Ile Glu Leu Ile  Ile Glu Leu Pro Lys  Tyr Ser Leu 
    1220                 1225                 1230             


Phe Glu  Leu Ser Asp Gly Ser  Arg Arg Met Leu Ala  Ser Ile Leu 
    1235                 1240                 1245             


Ser Thr  Asn Asn Lys Arg Gly  Glu Ile His Lys Gly  Asn Gln Ile 
    1250                 1255                 1260             


Phe Leu  Ser Gln Lys Phe Val  Lys Leu Leu Tyr His  Ala Lys Arg 
    1265                 1270                 1275             


Ile Ser  Asn Thr Ile Asn Glu  Asn His Arg Lys Tyr  Val Glu Asn 
    1280                 1285                 1290             


His Lys  Lys Glu Phe Glu Glu  Leu Phe Tyr Tyr Ile  Leu Glu Phe 
    1295                 1300                 1305             


Asn Glu  Asn Tyr Val Gly Ala  Lys Lys Asn Gly Lys  Leu Leu Asn 
    1310                 1315                 1320             


Ser Ala  Phe Gln Ser Trp Gln  Asn His Ser Ile Asp  Glu Leu Cys 
    1325                 1330                 1335             


Ser Ser  Phe Ile Gly Pro Thr  Gly Ser Glu Arg Lys  Gly Leu Phe 
    1340                 1345                 1350             


Glu Leu  Thr Ser Arg Gly Ser  Ala Ala Asp Phe Glu  Phe Leu Gly 
    1355                 1360                 1365             


Val Lys  Ile Pro Arg Tyr Arg  Asp Tyr Thr Pro Ser  Ser Leu Leu 
    1370                 1375                 1380             


Lys Asp  Ala Thr Leu Ile His  Gln Ser Val Thr Gly  Leu Tyr Glu 
    1385                 1390                 1395             


Thr Arg  Ile Asp Leu Ala Lys  Leu Gly Glu Gly 
    1400                 1405                 


<210>  23
<211>  1053
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Met Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
    50                  55                  60                  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
65                  70                  75                  80  


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
        115                 120                 125             


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
    130                 135                 140                 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
145                 150                 155                 160 


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
                165                 170                 175     


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
            180                 185                 190         


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
        195                 200                 205             


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
    210                 215                 220                 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
225                 230                 235                 240 


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
                245                 250                 255     


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
            260                 265                 270         


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
        275                 280                 285             


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
    290                 295                 300                 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
305                 310                 315                 320 


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
                325                 330                 335     


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
            340                 345                 350         


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
        355                 360                 365             


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
    370                 375                 380                 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
385                 390                 395                 400 


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
                405                 410                 415     


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
            420                 425                 430         


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
        435                 440                 445             


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
    450                 455                 460                 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
465                 470                 475                 480 


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
                485                 490                 495     


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
            500                 505                 510         


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
        515                 520                 525             


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
    530                 535                 540                 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
545                 550                 555                 560 


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
                565                 570                 575     


Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
            580                 585                 590         


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
        595                 600                 605             


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
    610                 615                 620                 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
625                 630                 635                 640 


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
                645                 650                 655     


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
            660                 665                 670         


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
        675                 680                 685             


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
    690                 695                 700                 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
705                 710                 715                 720 


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
                725                 730                 735     


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
            740                 745                 750         


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
        755                 760                 765             


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
785                 790                 795                 800 


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
                805                 810                 815     


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
            820                 825                 830         


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
        835                 840                 845             


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
    850                 855                 860                 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
865                 870                 875                 880 


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
                885                 890                 895     


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
            900                 905                 910         


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
        915                 920                 925             


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
    930                 935                 940                 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
945                 950                 955                 960 


Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly 
                965                 970                 975     


Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg Ile 
            980                 985                 990         


Glu Val Asn Met Ile Asp Ile Thr  Tyr Arg Glu Tyr Leu  Glu Asn Met 
        995                 1000                 1005             


Asn Asp  Lys Arg Pro Pro Arg  Ile Ile Lys Thr Ile  Ala Ser Lys 
    1010                 1015                 1020             


Thr Gln  Ser Ile Lys Lys Tyr  Ser Thr Asp Ile Leu  Gly Asn Leu 
    1025                 1030                 1035             


Tyr Glu  Val Lys Ser Lys Lys  His Pro Gln Ile Ile  Lys Lys Gly 
    1040                 1045                 1050             


<210>  24
<211>  1365
<212>  PRT
<213>  Streptococcus pyogenes

<400>  24

Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val Gly Trp Ala 
1               5                   10                  15      


Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu 
            20                  25                  30          


Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu 
        35                  40                  45              


Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr 
    50                  55                  60                  


Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln 
65                  70                  75                  80  


Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His 
                85                  90                  95      


Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg 
            100                 105                 110         


His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys 
        115                 120                 125             


Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp 
    130                 135                 140                 


Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys 
145                 150                 155                 160 


Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser 
                165                 170                 175     


Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu 
            180                 185                 190         


Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile 
        195                 200                 205             


Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala 
    210                 215                 220                 


Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala 
225                 230                 235                 240 


Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala 
                245                 250                 255     


Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu 
            260                 265                 270         


Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu 
        275                 280                 285             


Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg 
    290                 295                 300                 


Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys 
305                 310                 315                 320 


Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val 
                325                 330                 335     


Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser 
            340                 345                 350         


Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu 
        355                 360                 365             


Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu 
    370                 375                 380                 


Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg 
385                 390                 395                 400 


Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu 
                405                 410                 415     


His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp 
            420                 425                 430         


Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr 
        435                 440                 445             


Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg 
    450                 455                 460                 


Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp 
465                 470                 475                 480 


Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp 
                485                 490                 495     


Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr 
            500                 505                 510         


Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr 
        515                 520                 525             


Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala 
    530                 535                 540                 


Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln 
545                 550                 555                 560 


Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu 
                565                 570                 575     


Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His 
            580                 585                 590         


Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu 
        595                 600                 605             


Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu 
    610                 615                 620                 


Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe 
625                 630                 635                 640 


Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp 
                645                 650                 655     


Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser 
            660                 665                 670         


Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg 
        675                 680                 685             


Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp 
    690                 695                 700                 


Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu His 
705                 710                 715                 720 


Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln 
                725                 730                 735     


Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg His Lys 
            740                 745                 750         


Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln 
        755                 760                 765             


Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu Glu Gly 
    770                 775                 780                 


Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val Glu Asn 
785                 790                 795                 800 


Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly 
                805                 810                 815     


Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp 
            820                 825                 830         


Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys Asp Asp Ser 
        835                 840                 845             


Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser 
    850                 855                 860                 


Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp 
865                 870                 875                 880 


Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn 
                885                 890                 895     


Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly 
            900                 905                 910         


Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val 
        915                 920                 925             


Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp 
    930                 935                 940                 


Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val 
945                 950                 955                 960 


Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu Ile Asn 
                965                 970                 975     


Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val Gly Thr 
            980                 985                 990         


Ala Leu Ile Lys Lys Tyr Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly 
        995                 1000                 1005             


Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu 
    1010                 1015                 1020             


Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn 
    1025                 1030                 1035             


Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu 
    1040                 1045                 1050             


Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu 
    1055                 1060                 1065             


Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val 
    1070                 1075                 1080             


Leu Ser  Met Pro Gln Val Asn  Ile Val Lys Lys Thr  Glu Val Gln 
    1085                 1090                 1095             


Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser 
    1100                 1105                 1110             


Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr 
    1115                 1120                 1125             


Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr Ser Val  Leu Val Val 
    1130                 1135                 1140             


Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys 
    1145                 1150                 1155             


Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys 
    1160                 1165                 1170             


Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys 
    1175                 1180                 1185             


Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu 
    1190                 1195                 1200             


Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln 
    1205                 1210                 1215             


Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu 
    1220                 1225                 1230             


Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp 
    1235                 1240                 1245             


Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln His Lys  His Tyr Leu 
    1250                 1255                 1260             


Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile 
    1265                 1270                 1275             


Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys 
    1280                 1285                 1290             


His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His 
    1295                 1300                 1305             


Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr 
    1310                 1315                 1320             


Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu 
    1325                 1330                 1335             


Val Leu  Asp Ala Thr Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr 
    1340                 1345                 1350             


Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly Gly Asp  
    1355                 1360                 1365 


<210>  25
<211>  7
<212>  PRT
<213>  Simian virus 40

<400>  25

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  26
<211>  10
<212>  PRT
<213>  Simian virus 40

<400>  26

Pro Lys Lys Lys Arg Lys Val Glu Ala Ser 
1               5                   10  


<210>  27
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210>  28
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  28

Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   


<210>  29
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  29

Arg Gln Arg Arg Asn Glu Leu Lys Arg Ser Pro 
1               5                   10      


<210>  30
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  30

Asn Gln Ser Ser Asn Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly 
1               5                   10                  15      


Arg Ser Ser Gly Pro Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro 
            20                  25                  30          


Arg Asn Gln Gly Gly Tyr 
        35              


<210>  31
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  31

Arg Met Arg Ile Glx Phe Lys Asn Lys Gly Lys Asp Thr Ala Glu Leu 
1               5                   10                  15      


Arg Arg Arg Arg Val Glu Val Ser Val Glu Leu Arg Lys Ala Lys Lys 
            20                  25                  30          


Asp Glu Gln Ile Leu Lys Arg Arg Asn Val 
        35                  40          


<210>  32
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  32

Val Ser Arg Lys Arg Pro Arg Pro 
1               5               


<210>  33
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  33

Pro Pro Lys Lys Ala Arg Glu Asp 
1               5               


<210>  34
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  34

Pro Gln Pro Lys Lys Lys Pro Leu 
1               5               


<210>  35
<211>  12
<212>  PRT
<213>  Mus sp.

<400>  35

Ser Ala Leu Ile Lys Lys Lys Lys Lys Met Ala Pro 
1               5                   10          


<210>  36
<211>  5
<212>  PRT
<213>  Influenza virus

<400>  36

Asp Arg Leu Arg Arg 
1               5   


<210>  37
<211>  7
<212>  PRT
<213>  Influenza virus

<400>  37

Pro Lys Gln Lys Lys Arg Lys 
1               5           


<210>  38
<211>  10
<212>  PRT
<213>  Hepatitis D virus

<400>  38

Arg Lys Leu Lys Lys Lys Ile Lys Lys Leu 
1               5                   10  


<210>  39
<211>  10
<212>  PRT
<213>  Mus sp.

<400>  39

Arg Glu Lys Lys Lys Phe Leu Lys Arg Arg 
1               5                   10  


<210>  40
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  40

Lys Arg Lys Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys 
1               5                   10                  15      


Lys Ser Lys Lys 
            20  


<210>  41
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  41

Arg Lys Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys 
1               5                   10                  15      


Lys 
    


<210>  42
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42

Met Asp Pro Ile Arg Ser Arg Thr Pro Ser Pro Ala Arg Glu Leu Leu 
1               5                   10                  15      


Ser Gly Pro Gln Pro Asp Gly Val Gln Pro Thr Ala Asp Arg Gly Val 
            20                  25                  30          


Ser Pro Pro Ala Gly Gly Pro Leu Asp Gly Leu Pro Ala Arg Arg Thr 
        35                  40                  45              


Met Ser Arg Thr Arg Leu Pro Ser Pro Pro Ala Pro Ser Pro Ala Phe 
    50                  55                  60                  


Ser Ala Asp Ser Phe Ser Asp Leu Leu Arg Gln Phe Asp Pro Ser Leu 
65                  70                  75                  80  


Phe Asn Thr Ser Leu Phe Asp Ser Leu Pro Pro Phe Gly Ala His His 
                85                  90                  95      


Thr Glu Ala Ala Thr Gly Glu Trp Asp Glu Val Gln Ser Gly Leu Arg 
            100                 105                 110         


Ala Ala Asp Ala Pro Pro Pro Thr Met Arg Val Ala Val Thr Ala Ala 
        115                 120                 125             


Arg Pro Pro Arg Ala Lys Pro Ala Pro Arg Arg Arg Ala Ala Gln Pro 
    130                 135                 140                 


Ser Asp Ala Ser Pro Ala Ala Gln Val Asp Leu Arg Thr Leu Gly Tyr 
145                 150                 155                 160 


Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys Val Arg Ser Thr Val 
                165                 170                 175     


Ala Gln His His Glu Ala Leu Val Gly His Gly Phe Thr His Ala His 
            180                 185                 190         


Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu Gly Thr Val Ala Val 
        195                 200                 205             


Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu Ala Thr His Glu Ala 
    210                 215                 220                 


Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala Arg Ala Leu Glu Ala 
225                 230                 235                 240 


Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro Pro Leu Gln Leu Asp 
                245                 250                 255     


Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly Gly Val Thr Ala Val 
            260                 265                 270         


Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr Gly Ala Pro Leu Asn 
        275                 280                 285             


<210>  43
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43

Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro Asp Pro 
1               5                   10                  15      


Ala Leu Ala Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala Cys Leu 
            20                  25                  30          


Gly Gly Arg Pro Ala Leu Asp Ala Val Lys Lys Gly Leu Pro His Ala 
        35                  40                  45              


Pro Ala Leu Ile Lys Arg Thr Asn Arg Arg Ile Pro Glu Arg Thr Ser 
    50                  55                  60                  


His Arg Val Ala Asp His Ala Gln Val Val Arg Val Leu Gly Phe Phe 
65                  70                  75                  80  


Gln Cys His Ser His Pro Ala Gln Ala Phe Asp Asp Ala Met Thr Gln 
                85                  90                  95      


Phe Gly Met Ser Arg His Gly Leu Leu Gln Leu Phe Arg Arg Val Gly 
            100                 105                 110         


Val Thr Glu Leu Glu Ala Arg Ser Gly Thr Leu Pro Pro Ala Ser Gln 
        115                 120                 125             


Arg Trp Asp Arg Ile Leu Gln Ala Ser Gly Met Lys Arg Ala Lys Pro 
    130                 135                 140                 


Ser Pro Thr Ser Thr Gln Thr Pro Asp Gln Ala Ser Leu His Ala Phe 
145                 150                 155                 160 


Ala Asp Ser Leu Glu Arg Asp Leu Asp Ala Pro Ser Pro Met His Glu 
                165                 170                 175     


Gly Asp Gln Thr Arg Ala 
            180         


<210>  44
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44

Glu Asn Leu Tyr Phe Gln Gly 
1               5           


<210>  45
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45

Glu Gly Phe Arg 
1               


<210>  46
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46

Ala Pro Arg Pro Gly 
1               5   


<210>  47
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  PEPTIDE
<222>  (5)..(5)
<223>  PEG-modified

<400>  47

Ala Pro Arg Pro Gly 
1               5   


<210>  48
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48
gccaaattgg acgaccctcg                                                   20


<210>  49
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49
cgaggagacc cccgtttcgg                                                   20


<210>  50
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50
cccgccgccg ccgtggctcg                                                   20


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51
tgagctctac gagatccaca                                                   20


<210>  52
<211>  2904
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  52

Met Ser Lys Glu Gln Leu Leu Ile Gln Arg Ser Ser Ala Ala Glu Arg 
1               5                   10                  15      


Cys Arg Arg Tyr Arg Gln Lys Met Ser Ala Glu Gln Arg Ala Ser Asp 
            20                  25                  30          


Leu Glu Arg Arg Arg Arg Leu Gln Gln Asn Val Ser Glu Glu Gln Leu 
        35                  40                  45              


Leu Glu Lys Arg Arg Ser Glu Ala Glu Lys Gln Arg Arg His Arg Gln 
    50                  55                  60                  


Lys Met Ser Lys Asp Gln Arg Ala Phe Glu Val Glu Arg Arg Arg Trp 
65                  70                  75                  80  


Arg Arg Gln Asn Met Ser Arg Glu Gln Ser Ser Thr Ser Thr Thr Asn 
                85                  90                  95      


Thr Gly Arg Asn Cys Leu Leu Ser Lys Asn Gly Val His Glu Asp Ala 
            100                 105                 110         


Ile Leu Glu His Ser Cys Gly Gly Met Thr Val Arg Cys Glu Phe Cys 
        115                 120                 125             


Leu Ser Leu Asn Phe Ser Asp Glu Lys Pro Ser Asp Gly Lys Phe Thr 
    130                 135                 140                 


Arg Cys Cys Ser Lys Gly Lys Val Cys Pro Asn Asp Ile His Phe Pro 
145                 150                 155                 160 


Asp Tyr Pro Ala Tyr Leu Lys Arg Leu Met Thr Asn Glu Asp Ser Asp 
                165                 170                 175     


Ser Lys Asn Phe Met Glu Asn Ile Arg Ser Ile Asn Ser Ser Phe Ala 
            180                 185                 190         


Phe Ala Ser Met Gly Ala Asn Ile Ala Ser Pro Ser Gly Tyr Gly Pro 
        195                 200                 205             


Tyr Cys Phe Arg Ile His Gly Gln Val Tyr His Arg Thr Gly Thr Leu 
    210                 215                 220                 


His Pro Ser Asp Gly Val Ser Arg Lys Phe Ala Gln Leu Tyr Ile Leu 
225                 230                 235                 240 


Asp Thr Ala Glu Ala Thr Ser Lys Arg Leu Ala Met Pro Glu Asn Gln 
                245                 250                 255     


Gly Cys Ser Glu Arg Leu Met Ile Asn Ile Asn Asn Leu Met His Glu 
            260                 265                 270         


Ile Asn Glu Leu Thr Lys Ser Tyr Lys Met Leu His Glu Val Glu Lys 
        275                 280                 285             


Glu Ala Gln Ser Glu Ala Ala Ala Lys Gly Ile Ala Pro Thr Glu Val 
    290                 295                 300                 


Thr Met Ala Ile Lys Tyr Asp Arg Asn Ser Asp Pro Gly Arg Tyr Asn 
305                 310                 315                 320 


Ser Pro Arg Val Thr Glu Val Ala Val Ile Phe Arg Asn Glu Asp Gly 
                325                 330                 335     


Glu Pro Pro Phe Glu Arg Asp Leu Leu Ile His Cys Lys Pro Asp Pro 
            340                 345                 350         


Asn Asn Pro Asn Ala Thr Lys Met Lys Gln Ile Ser Ile Leu Phe Pro 
        355                 360                 365             


Thr Leu Asp Ala Met Thr Tyr Pro Ile Leu Phe Pro His Gly Glu Lys 
    370                 375                 380                 


Gly Trp Gly Thr Asp Ile Ala Leu Arg Leu Arg Asp Asn Ser Val Ile 
385                 390                 395                 400 


Asp Asn Asn Thr Arg Gln Asn Val Arg Thr Arg Val Thr Gln Met Gln 
                405                 410                 415     


Tyr Tyr Gly Phe His Leu Ser Val Arg Asp Thr Phe Asn Pro Ile Leu 
            420                 425                 430         


Asn Ala Gly Lys Leu Thr Gln Gln Phe Ile Val Asp Ser Tyr Ser Lys 
        435                 440                 445             


Met Glu Ala Asn Arg Ile Asn Phe Ile Lys Ala Asn Gln Ser Lys Leu 
    450                 455                 460                 


Arg Val Glu Lys Tyr Ser Gly Leu Met Asp Tyr Leu Lys Ser Arg Ser 
465                 470                 475                 480 


Glu Asn Asp Asn Val Pro Ile Gly Lys Met Ile Ile Leu Pro Ser Ser 
                485                 490                 495     


Phe Glu Gly Ser Pro Arg Asn Met Gln Gln Arg Tyr Gln Asp Ala Met 
            500                 505                 510         


Ala Ile Val Thr Lys Tyr Gly Lys Pro Asp Leu Phe Ile Thr Met Thr 
        515                 520                 525             


Cys Asn Pro Lys Trp Ala Asp Ile Thr Asn Asn Leu Gln Arg Trp Gln 
    530                 535                 540                 


Lys Val Glu Asn Arg Pro Asp Leu Val Ala Arg Val Phe Asn Ile Lys 
545                 550                 555                 560 


Leu Asn Ala Leu Leu Asn Asp Ile Cys Lys Phe His Leu Phe Gly Lys 
                565                 570                 575     


Val Ile Ala Lys Ile His Val Ile Glu Phe Gln Lys Arg Gly Leu Pro 
            580                 585                 590         


His Ala His Ile Leu Leu Ile Leu Asp Ser Glu Ser Lys Leu Arg Ser 
        595                 600                 605             


Glu Asp Asp Ile Asp Arg Ile Val Lys Ala Glu Ile Pro Asp Glu Asp 
    610                 615                 620                 


Gln Cys Pro Arg Leu Phe Gln Ile Val Lys Ser Asn Met Val His Gly 
625                 630                 635                 640 


Pro Cys Gly Ile Gln Asn Pro Asn Ser Pro Cys Met Glu Asn Gly Lys 
                645                 650                 655     


Cys Ser Lys Gly Tyr Pro Lys Glu Phe Gln Asn Ala Thr Ile Gly Asn 
            660                 665                 670         


Ile Asp Gly Tyr Pro Lys Tyr Lys Arg Arg Ser Gly Ser Thr Met Ser 
        675                 680                 685             


Ile Gly Asn Lys Val Val Asp Asn Thr Trp Ile Val Pro Tyr Asn Pro 
    690                 695                 700                 


Tyr Leu Cys Leu Lys Tyr Asn Cys His Ile Asn Val Glu Val Cys Ala 
705                 710                 715                 720 


Ser Ile Lys Ser Val Lys Tyr Leu Phe Lys Tyr Ile Tyr Lys Gly His 
                725                 730                 735     


Asp Cys Ala Asn Ile Gln Ile Ser Glu Lys Asn Ile Ile Asn His Asp 
            740                 745                 750         


Glu Val Gln Asp Phe Ile Asp Ser Arg Tyr Val Ser Ala Pro Glu Ala 
        755                 760                 765             


Val Trp Arg Leu Phe Ala Met Arg Met His Asp Gln Ser His Ala Ile 
    770                 775                 780                 


Thr Arg Leu Ala Ile His Leu Pro Asn Asp Gln Asn Leu Tyr Phe His 
785                 790                 795                 800 


Thr Asp Asp Phe Ala Glu Val Leu Asp Arg Ala Lys Arg His Asn Ser 
                805                 810                 815     


Thr Leu Met Ala Trp Phe Leu Leu Asn Arg Glu Asp Ser Asp Ala Arg 
            820                 825                 830         


Asn Tyr Tyr Tyr Trp Glu Ile Pro Gln His Tyr Val Phe Asn Asn Ser 
        835                 840                 845             


Leu Trp Thr Lys Arg Arg Lys Gly Gly Asn Lys Val Leu Gly Arg Leu 
    850                 855                 860                 


Phe Thr Val Ser Phe Arg Glu Pro Glu Arg Tyr Tyr Leu Arg Leu Leu 
865                 870                 875                 880 


Leu Leu His Val Lys Gly Ala Ile Ser Phe Glu Asp Leu Arg Thr Val 
                885                 890                 895     


Gly Gly Val Thr Tyr Asp Thr Phe His Glu Ala Ala Lys His Arg Gly 
            900                 905                 910         


Leu Leu Leu Asp Asp Thr Ile Trp Lys Asp Thr Ile Asp Asp Ala Ile 
        915                 920                 925             


Ile Leu Asn Met Pro Lys Gln Leu Arg Gln Leu Phe Ala Tyr Ile Cys 
    930                 935                 940                 


Val Phe Gly Cys Pro Ser Ala Ala Asp Lys Leu Trp Asp Glu Asn Lys 
945                 950                 955                 960 


Ser His Phe Ile Glu Asp Phe Cys Trp Lys Leu His Arg Arg Glu Gly 
                965                 970                 975     


Ala Cys Val Asn Cys Glu Met His Ala Leu Asn Glu Ile Gln Glu Val 
            980                 985                 990         


Phe Thr Leu His Gly Met Lys Cys  Ser His Phe Lys Leu  Pro Asp Tyr 
        995                 1000                 1005             


Pro Leu  Leu Met Asn Ala Asn  Thr Cys Asp Gln Leu  Tyr Glu Gln 
    1010                 1015                 1020             


Gln Gln  Ala Glu Val Leu Ile  Asn Ser Leu Asn Asp  Glu Gln Leu 
    1025                 1030                 1035             


Ala Ala  Phe Gln Thr Ile Thr  Ser Ala Ile Glu Asp  Gln Thr Val 
    1040                 1045                 1050             


His Pro  Lys Cys Phe Phe Leu  Asp Gly Pro Gly Gly  Ser Gly Lys 
    1055                 1060                 1065             


Thr Tyr  Leu Tyr Lys Val Leu  Thr His Tyr Ile Arg  Gly Arg Gly 
    1070                 1075                 1080             


Gly Thr  Val Leu Pro Thr Ala  Ser Thr Gly Ile Ala  Ala Asn Leu 
    1085                 1090                 1095             


Leu Leu  Gly Gly Arg Thr Phe  His Ser Gln Tyr Lys  Leu Pro Ile 
    1100                 1105                 1110             


Pro Leu  Asn Glu Thr Ser Ile  Ser Arg Leu Asp Ile  Lys Ser Glu 
    1115                 1120                 1125             


Val Ala  Lys Thr Ile Lys Lys  Ala Gln Leu Leu Ile  Ile Asp Glu 
    1130                 1135                 1140             


Cys Thr  Met Ala Ser Ser His  Ala Ile Asn Ala Ile  Asp Arg Leu 
    1145                 1150                 1155             


Leu Arg  Glu Ile Met Asn Leu  Asn Val Ala Phe Gly  Gly Lys Val 
    1160                 1165                 1170             


Leu Leu  Leu Gly Gly Asp Phe  Arg Gln Cys Leu Ser  Ile Val Pro 
    1175                 1180                 1185             


His Ala  Met Arg Ser Ala Ile  Val Gln Thr Ser Leu  Lys Tyr Cys 
    1190                 1195                 1200             


Asn Val  Trp Gly Cys Phe Arg  Lys Leu Ser Leu Lys  Thr Asn Met 
    1205                 1210                 1215             


Arg Ser  Glu Asp Ser Ala Tyr  Ser Glu Trp Leu Val  Lys Leu Gly 
    1220                 1225                 1230             


Asp Gly  Lys Leu Asp Ser Ser  Phe His Leu Gly Met  Asp Ile Ile 
    1235                 1240                 1245             


Glu Ile  Pro His Glu Met Ile  Cys Asn Gly Ser Ile  Ile Glu Ala 
    1250                 1255                 1260             


Thr Phe  Gly Asn Ser Ile Ser  Ile Asp Asn Ile Lys  Asn Ile Ser 
    1265                 1270                 1275             


Lys Arg  Ala Ile Leu Cys Pro  Lys Asn Glu His Val  Gln Lys Leu 
    1280                 1285                 1290             


Asn Glu  Glu Ile Leu Asp Ile  Leu Asp Gly Asp Phe  His Thr Tyr 
    1295                 1300                 1305             


Leu Ser  Asp Asp Ser Ile Asp  Ser Thr Asp Asp Ala  Glu Lys Glu 
    1310                 1315                 1320             


Asn Phe  Pro Ile Glu Phe Leu  Asn Ser Ile Thr Pro  Ser Gly Met 
    1325                 1330                 1335             


Pro Cys  His Lys Leu Lys Leu  Lys Val Gly Ala Ile  Ile Met Leu 
    1340                 1345                 1350             


Leu Arg  Asn Leu Asn Ser Lys  Trp Gly Leu Cys Asn  Gly Thr Arg 
    1355                 1360                 1365             


Phe Ile  Ile Lys Arg Leu Arg  Pro Asn Ile Ile Glu  Ala Glu Val 
    1370                 1375                 1380             


Leu Thr  Gly Ser Ala Glu Gly  Glu Val Val Leu Ile  Pro Arg Ile 
    1385                 1390                 1395             


Asp Leu  Ser Pro Ser Asp Thr  Gly Leu Pro Phe Lys  Leu Ile Arg 
    1400                 1405                 1410             


Arg Gln  Phe Pro Val Met Pro  Ala Phe Ala Met Thr  Ile Asn Lys 
    1415                 1420                 1425             


Ser Gln  Gly Gln Thr Leu Asp  Arg Val Gly Ile Phe  Leu Pro Glu 
    1430                 1435                 1440             


Pro Val  Phe Ala His Gly Gln  Leu Tyr Val Ala Phe  Ser Arg Val 
    1445                 1450                 1455             


Arg Arg  Ala Cys Asp Val Lys  Val Lys Val Val Asn  Thr Ser Ser 
    1460                 1465                 1470             


Gln Gly  Lys Leu Val Lys His  Ser Glu Ser Val Phe  Thr Leu Asn 
    1475                 1480                 1485             


Val Val  Tyr Arg Glu Ile Leu  Glu Ser Gly Ser Glu  Thr Pro Gly 
    1490                 1495                 1500             


Thr Ser  Glu Ser Ala Thr Pro  Glu Ser Gly Ser Pro  Lys Lys Lys 
    1505                 1510                 1515             


Arg Lys  Val Asp Lys Lys Tyr  Ser Ile Gly Leu Ala  Ile Gly Thr 
    1520                 1525                 1530             


Asn Ser  Val Gly Trp Ala Val  Ile Thr Asp Glu Tyr  Lys Val Pro 
    1535                 1540                 1545             


Ser Lys  Lys Phe Lys Val Leu  Gly Asn Thr Asp Arg  His Ser Ile 
    1550                 1555                 1560             


Lys Lys  Asn Leu Ile Gly Ala  Leu Leu Phe Asp Ser  Gly Glu Thr 
    1565                 1570                 1575             


Ala Glu  Ala Thr Arg Leu Lys  Arg Thr Ala Arg Arg  Arg Tyr Thr 
    1580                 1585                 1590             


Arg Arg  Lys Asn Arg Ile Cys  Tyr Leu Gln Glu Ile  Phe Ser Asn 
    1595                 1600                 1605             


Glu Met  Ala Lys Val Asp Asp  Ser Phe Phe His Arg  Leu Glu Glu 
    1610                 1615                 1620             


Ser Phe  Leu Val Glu Glu Asp  Lys Lys His Glu Arg  His Pro Ile 
    1625                 1630                 1635             


Phe Gly  Asn Ile Val Asp Glu  Val Ala Tyr His Glu  Lys Tyr Pro 
    1640                 1645                 1650             


Thr Ile  Tyr His Leu Arg Lys  Lys Leu Val Asp Ser  Thr Asp Lys 
    1655                 1660                 1665             


Ala Asp  Leu Arg Leu Ile Tyr  Leu Ala Leu Ala His  Met Ile Lys 
    1670                 1675                 1680             


Phe Arg  Gly His Phe Leu Ile  Glu Gly Asp Leu Asn  Pro Asp Asn 
    1685                 1690                 1695             


Ser Asp  Val Asp Lys Leu Phe  Ile Gln Leu Val Gln  Thr Tyr Asn 
    1700                 1705                 1710             


Gln Leu  Phe Glu Glu Asn Pro  Ile Asn Ala Ser Gly  Val Asp Ala 
    1715                 1720                 1725             


Lys Ala  Ile Leu Ser Ala Arg  Leu Ser Lys Ser Arg  Arg Leu Glu 
    1730                 1735                 1740             


Asn Leu  Ile Ala Gln Leu Pro  Gly Glu Lys Lys Asn  Gly Leu Phe 
    1745                 1750                 1755             


Gly Asn  Leu Ile Ala Leu Ser  Leu Gly Leu Thr Pro  Asn Phe Lys 
    1760                 1765                 1770             


Ser Asn  Phe Asp Leu Ala Glu  Asp Ala Lys Leu Gln  Leu Ser Lys 
    1775                 1780                 1785             


Asp Thr  Tyr Asp Asp Asp Leu  Asp Asn Leu Leu Ala  Gln Ile Gly 
    1790                 1795                 1800             


Asp Gln  Tyr Ala Asp Leu Phe  Leu Ala Ala Lys Asn  Leu Ser Asp 
    1805                 1810                 1815             


Ala Ile  Leu Leu Ser Asp Ile  Leu Arg Val Asn Thr  Glu Ile Thr 
    1820                 1825                 1830             


Lys Ala  Pro Leu Ser Ala Ser  Met Ile Lys Arg Tyr  Asp Glu His 
    1835                 1840                 1845             


His Gln  Asp Leu Thr Leu Leu  Lys Ala Leu Val Arg  Gln Gln Leu 
    1850                 1855                 1860             


Pro Glu  Lys Tyr Lys Glu Ile  Phe Phe Asp Gln Ser  Lys Asn Gly 
    1865                 1870                 1875             


Tyr Ala  Gly Tyr Ile Asp Gly  Gly Ala Ser Gln Glu  Glu Phe Tyr 
    1880                 1885                 1890             


Lys Phe  Ile Lys Pro Ile Leu  Glu Lys Met Asp Gly  Thr Glu Glu 
    1895                 1900                 1905             


Leu Leu  Val Lys Leu Asn Arg  Glu Asp Leu Leu Arg  Lys Gln Arg 
    1910                 1915                 1920             


Thr Phe  Asp Asn Gly Ser Ile  Pro His Gln Ile His  Leu Gly Glu 
    1925                 1930                 1935             


Leu His  Ala Ile Leu Arg Arg  Gln Glu Asp Phe Tyr  Pro Phe Leu 
    1940                 1945                 1950             


Lys Asp  Asn Arg Glu Lys Ile  Glu Lys Ile Leu Thr  Phe Arg Ile 
    1955                 1960                 1965             


Pro Tyr  Tyr Val Gly Pro Leu  Ala Arg Gly Asn Ser  Arg Phe Ala 
    1970                 1975                 1980             


Trp Met  Thr Arg Lys Ser Glu  Glu Thr Ile Thr Pro  Trp Asn Phe 
    1985                 1990                 1995             


Glu Glu  Val Val Asp Lys Gly  Ala Ser Ala Gln Ser  Phe Ile Glu 
    2000                 2005                 2010             


Arg Met  Thr Asn Phe Asp Lys  Asn Leu Pro Asn Glu  Lys Val Leu 
    2015                 2020                 2025             


Pro Lys  His Ser Leu Leu Tyr  Glu Tyr Phe Thr Val  Tyr Asn Glu 
    2030                 2035                 2040             


Leu Thr  Lys Val Lys Tyr Val  Thr Glu Gly Met Arg  Lys Pro Ala 
    2045                 2050                 2055             


Phe Leu  Ser Gly Glu Gln Lys  Lys Ala Ile Val Asp  Leu Leu Phe 
    2060                 2065                 2070             


Lys Thr  Asn Arg Lys Val Thr  Val Lys Gln Leu Lys  Glu Asp Tyr 
    2075                 2080                 2085             


Phe Lys  Lys Ile Glu Cys Phe  Asp Ser Val Glu Ile  Ser Gly Val 
    2090                 2095                 2100             


Glu Asp  Arg Phe Asn Ala Ser  Leu Gly Thr Tyr His  Asp Leu Leu 
    2105                 2110                 2115             


Lys Ile  Ile Lys Asp Lys Asp  Phe Leu Asp Asn Glu  Glu Asn Glu 
    2120                 2125                 2130             


Asp Ile  Leu Glu Asp Ile Val  Leu Thr Leu Thr Leu  Phe Glu Asp 
    2135                 2140                 2145             


Arg Glu  Met Ile Glu Glu Arg  Leu Lys Thr Tyr Ala  His Leu Phe 
    2150                 2155                 2160             


Asp Asp  Lys Val Met Lys Gln  Leu Lys Arg Arg Arg  Tyr Thr Gly 
    2165                 2170                 2175             


Trp Gly  Arg Leu Ser Arg Lys  Leu Ile Asn Gly Ile  Arg Asp Lys 
    2180                 2185                 2190             


Gln Ser  Gly Lys Thr Ile Leu  Asp Phe Leu Lys Ser  Asp Gly Phe 
    2195                 2200                 2205             


Ala Asn  Arg Asn Phe Met Gln  Leu Ile His Asp Asp  Ser Leu Thr 
    2210                 2215                 2220             


Phe Lys  Glu Asp Ile Gln Lys  Ala Gln Val Ser Gly  Gln Gly Asp 
    2225                 2230                 2235             


Ser Leu  His Glu His Ile Ala  Asn Leu Ala Gly Ser  Pro Ala Ile 
    2240                 2245                 2250             


Lys Lys  Gly Ile Leu Gln Thr  Val Lys Val Val Asp  Glu Leu Val 
    2255                 2260                 2265             


Lys Val  Met Gly Arg His Lys  Pro Glu Asn Ile Val  Ile Glu Met 
    2270                 2275                 2280             


Ala Arg  Glu Asn Gln Thr Thr  Gln Lys Gly Gln Lys  Asn Ser Arg 
    2285                 2290                 2295             


Glu Arg  Met Lys Arg Ile Glu  Glu Gly Ile Lys Glu  Leu Gly Ser 
    2300                 2305                 2310             


Gln Ile  Leu Lys Glu His Pro  Val Glu Asn Thr Gln  Leu Gln Asn 
    2315                 2320                 2325             


Glu Lys  Leu Tyr Leu Tyr Tyr  Leu Gln Asn Gly Arg  Asp Met Tyr 
    2330                 2335                 2340             


Val Asp  Gln Glu Leu Asp Ile  Asn Arg Leu Ser Asp  Tyr Asp Val 
    2345                 2350                 2355             


Asp His  Ile Val Pro Gln Ser  Phe Leu Lys Asp Asp  Ser Ile Asp 
    2360                 2365                 2370             


Asn Lys  Val Leu Thr Arg Ser  Asp Lys Asn Arg Gly  Lys Ser Asp 
    2375                 2380                 2385             


Asn Val  Pro Ser Glu Glu Val  Val Lys Lys Met Lys  Asn Tyr Trp 
    2390                 2395                 2400             


Arg Gln  Leu Leu Asn Ala Lys  Leu Ile Thr Gln Arg  Lys Phe Asp 
    2405                 2410                 2415             


Asn Leu  Thr Lys Ala Glu Arg  Gly Gly Leu Ser Glu  Leu Asp Lys 
    2420                 2425                 2430             


Ala Gly  Phe Ile Lys Arg Gln  Leu Val Glu Thr Arg  Gln Ile Thr 
    2435                 2440                 2445             


Lys His  Val Ala Gln Ile Leu  Asp Ser Arg Met Asn  Thr Lys Tyr 
    2450                 2455                 2460             


Asp Glu  Asn Asp Lys Leu Ile  Arg Glu Val Lys Val  Ile Thr Leu 
    2465                 2470                 2475             


Lys Ser  Lys Leu Val Ser Asp  Phe Arg Lys Asp Phe  Gln Phe Tyr 
    2480                 2485                 2490             


Lys Val  Arg Glu Ile Asn Asn  Tyr His His Ala His  Asp Ala Tyr 
    2495                 2500                 2505             


Leu Asn  Ala Val Val Gly Thr  Ala Leu Ile Lys Lys  Tyr Pro Lys 
    2510                 2515                 2520             


Leu Glu  Ser Glu Phe Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val 
    2525                 2530                 2535             


Arg Lys  Met Ile Ala Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr 
    2540                 2545                 2550             


Ala Lys  Tyr Phe Phe Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr 
    2555                 2560                 2565             


Glu Ile  Thr Leu Ala Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile 
    2570                 2575                 2580             


Glu Thr  Asn Gly Glu Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg 
    2585                 2590                 2595             


Asp Phe  Ala Thr Val Arg Lys  Val Leu Ser Met Pro  Gln Val Asn 
    2600                 2605                 2610             


Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu 
    2615                 2620                 2625             


Ser Ile  Leu Pro Lys Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys 
    2630                 2635                 2640             


Lys Asp  Trp Asp Pro Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr 
    2645                 2650                 2655             


Val Ala  Tyr Ser Val Leu Val  Val Ala Lys Val Glu  Lys Gly Lys 
    2660                 2665                 2670             


Ser Lys  Lys Leu Lys Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile 
    2675                 2680                 2685             


Met Glu  Arg Ser Ser Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu 
    2690                 2695                 2700             


Ala Lys  Gly Tyr Lys Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu 
    2705                 2710                 2715             


Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met 
    2720                 2725                 2730             


Leu Ala  Ser Ala Gly Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu 
    2735                 2740                 2745             


Pro Ser  Lys Tyr Val Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu 
    2750                 2755                 2760             


Lys Leu  Lys Gly Ser Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe 
    2765                 2770                 2775             


Val Glu  Gln His Lys His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile 
    2780                 2785                 2790             


Ser Glu  Phe Ser Lys Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp 
    2795                 2800                 2805             


Lys Val  Leu Ser Ala Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg 
    2810                 2815                 2820             


Glu Gln  Ala Glu Asn Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu 
    2825                 2830                 2835             


Gly Ala  Pro Ala Ala Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg 
    2840                 2845                 2850             


Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile 
    2855                 2860                 2865             


His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser 
    2870                 2875                 2880             


Gln Leu  Gly Gly Asp Lys Arg  Pro Ala Ala Thr Lys  Lys Ala Gly 
    2885                 2890                 2895             


Gln Ala  Lys Lys Lys Lys 
    2900                 


<210>  53
<211>  2904
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  53

Met Gly Ser Pro Lys Lys Lys Arg Lys Val Asp Lys Lys Tyr Ser Ile 
1               5                   10                  15      


Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp 
            20                  25                  30          


Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp 
        35                  40                  45              


Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser 
    50                  55                  60                  


Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg 
65                  70                  75                  80  


Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser 
                85                  90                  95      


Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu 
            100                 105                 110         


Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe 
        115                 120                 125             


Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile 
    130                 135                 140                 


Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu 
145                 150                 155                 160 


Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His 
                165                 170                 175     


Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys 
            180                 185                 190         


Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn 
        195                 200                 205             


Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg 
    210                 215                 220                 


Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly 
225                 230                 235                 240 


Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly 
                245                 250                 255     


Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys 
            260                 265                 270         


Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu 
        275                 280                 285             


Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn 
    290                 295                 300                 


Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu 
305                 310                 315                 320 


Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu 
                325                 330                 335     


His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu 
            340                 345                 350         


Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr 
        355                 360                 365             


Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe 
    370                 375                 380                 


Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val 
385                 390                 395                 400 


Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn 
                405                 410                 415     


Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu 
            420                 425                 430         


Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys 
        435                 440                 445             


Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu 
    450                 455                 460                 


Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu 
465                 470                 475                 480 


Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser 
                485                 490                 495     


Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro 
            500                 505                 510         


Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr 
        515                 520                 525             


Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg 
    530                 535                 540                 


Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu 
545                 550                 555                 560 


Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp 
                565                 570                 575     


Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val 
            580                 585                 590         


Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys 
        595                 600                 605             


Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile 
    610                 615                 620                 


Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met 
625                 630                 635                 640 


Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val 
                645                 650                 655     


Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser 
            660                 665                 670         


Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile 
        675                 680                 685             


Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln 
    690                 695                 700                 


Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala 
705                 710                 715                 720 


Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu 
                725                 730                 735     


Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val 
            740                 745                 750         


Val Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile 
        755                 760                 765             


Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys 
    770                 775                 780                 


Asn Ser Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu 
785                 790                 795                 800 


Gly Ser Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln 
                805                 810                 815     


Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr 
            820                 825                 830         


Val Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp 
        835                 840                 845             


His Ile Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys 
    850                 855                 860                 


Val Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro 
865                 870                 875                 880 


Ser Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu 
                885                 890                 895     


Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala 
            900                 905                 910         


Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg 
        915                 920                 925             


Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu 
    930                 935                 940                 


Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg 
945                 950                 955                 960 


Glu Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser Asp Phe Arg 
                965                 970                 975     


Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu Ile Asn Asn Tyr His His 
            980                 985                 990         


Ala His Asp Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
        995                 1000                 1005             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1010                 1015                 1020             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile 
    1025                 1030                 1035             


Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn 
    1040                 1045                 1050             


Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys 
    1055                 1060                 1065             


Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp 
    1070                 1075                 1080             


Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg Lys Val  Leu Ser Met 
    1085                 1090                 1095             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly 
    1100                 1105                 1110             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu 
    1115                 1120                 1125             


Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe 
    1130                 1135                 1140             


Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu Val Val  Ala Lys Val 
    1145                 1150                 1155             


Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu 
    1160                 1165                 1170             


Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile 
    1175                 1180                 1185             


Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu 
    1190                 1195                 1200             


Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly 
    1205                 1210                 1215             


Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn 
    1220                 1225                 1230             


Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala 
    1235                 1240                 1245             


Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln 
    1250                 1255                 1260             


Lys Gln  Leu Phe Val Glu Gln  His Lys His Tyr Leu  Asp Glu Ile 
    1265                 1270                 1275             


Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp 
    1280                 1285                 1290             


Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp 
    1295                 1300                 1305             


Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr 
    1310                 1315                 1320             


Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr 
    1325                 1330                 1335             


Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp 
    1340                 1345                 1350             


Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1355                 1360                 1365             


Ile Asp  Leu Ser Gln Leu Gly  Gly Asp Lys Arg Pro  Ala Ala Thr 
    1370                 1375                 1380             


Lys Lys  Ala Gly Gln Ala Lys  Lys Lys Lys Ser Gly  Ser Glu Thr 
    1385                 1390                 1395             


Pro Gly  Thr Ser Glu Ser Ala  Thr Pro Glu Ser Ser  Lys Glu Gln 
    1400                 1405                 1410             


Leu Leu  Ile Gln Arg Ser Ser  Ala Ala Glu Arg Cys  Arg Arg Tyr 
    1415                 1420                 1425             


Arg Gln  Lys Met Ser Ala Glu  Gln Arg Ala Ser Asp  Leu Glu Arg 
    1430                 1435                 1440             


Arg Arg  Arg Leu Gln Gln Asn  Val Ser Glu Glu Gln  Leu Leu Glu 
    1445                 1450                 1455             


Lys Arg  Arg Ser Glu Ala Glu  Lys Gln Arg Arg His  Arg Gln Lys 
    1460                 1465                 1470             


Met Ser  Lys Asp Gln Arg Ala  Phe Glu Val Glu Arg  Arg Arg Trp 
    1475                 1480                 1485             


Arg Arg  Gln Asn Met Ser Arg  Glu Gln Ser Ser Thr  Ser Thr Thr 
    1490                 1495                 1500             


Asn Thr  Gly Arg Asn Cys Leu  Leu Ser Lys Asn Gly  Val His Glu 
    1505                 1510                 1515             


Asp Ala  Ile Leu Glu His Ser  Cys Gly Gly Met Thr  Val Arg Cys 
    1520                 1525                 1530             


Glu Phe  Cys Leu Ser Leu Asn  Phe Ser Asp Glu Lys  Pro Ser Asp 
    1535                 1540                 1545             


Gly Lys  Phe Thr Arg Cys Cys  Ser Lys Gly Lys Val  Cys Pro Asn 
    1550                 1555                 1560             


Asp Ile  His Phe Pro Asp Tyr  Pro Ala Tyr Leu Lys  Arg Leu Met 
    1565                 1570                 1575             


Thr Asn  Glu Asp Ser Asp Ser  Lys Asn Phe Met Glu  Asn Ile Arg 
    1580                 1585                 1590             


Ser Ile  Asn Ser Ser Phe Ala  Phe Ala Ser Met Gly  Ala Asn Ile 
    1595                 1600                 1605             


Ala Ser  Pro Ser Gly Tyr Gly  Pro Tyr Cys Phe Arg  Ile His Gly 
    1610                 1615                 1620             


Gln Val  Tyr His Arg Thr Gly  Thr Leu His Pro Ser  Asp Gly Val 
    1625                 1630                 1635             


Ser Arg  Lys Phe Ala Gln Leu  Tyr Ile Leu Asp Thr  Ala Glu Ala 
    1640                 1645                 1650             


Thr Ser  Lys Arg Leu Ala Met  Pro Glu Asn Gln Gly  Cys Ser Glu 
    1655                 1660                 1665             


Arg Leu  Met Ile Asn Ile Asn  Asn Leu Met His Glu  Ile Asn Glu 
    1670                 1675                 1680             


Leu Thr  Lys Ser Tyr Lys Met  Leu His Glu Val Glu  Lys Glu Ala 
    1685                 1690                 1695             


Gln Ser  Glu Ala Ala Ala Lys  Gly Ile Ala Pro Thr  Glu Val Thr 
    1700                 1705                 1710             


Met Ala  Ile Lys Tyr Asp Arg  Asn Ser Asp Pro Gly  Arg Tyr Asn 
    1715                 1720                 1725             


Ser Pro  Arg Val Thr Glu Val  Ala Val Ile Phe Arg  Asn Glu Asp 
    1730                 1735                 1740             


Gly Glu  Pro Pro Phe Glu Arg  Asp Leu Leu Ile His  Cys Lys Pro 
    1745                 1750                 1755             


Asp Pro  Asn Asn Pro Asn Ala  Thr Lys Met Lys Gln  Ile Ser Ile 
    1760                 1765                 1770             


Leu Phe  Pro Thr Leu Asp Ala  Met Thr Tyr Pro Ile  Leu Phe Pro 
    1775                 1780                 1785             


His Gly  Glu Lys Gly Trp Gly  Thr Asp Ile Ala Leu  Arg Leu Arg 
    1790                 1795                 1800             


Asp Asn  Ser Val Ile Asp Asn  Asn Thr Arg Gln Asn  Val Arg Thr 
    1805                 1810                 1815             


Arg Val  Thr Gln Met Gln Tyr  Tyr Gly Phe His Leu  Ser Val Arg 
    1820                 1825                 1830             


Asp Thr  Phe Asn Pro Ile Leu  Asn Ala Gly Lys Leu  Thr Gln Gln 
    1835                 1840                 1845             


Phe Ile  Val Asp Ser Tyr Ser  Lys Met Glu Ala Asn  Arg Ile Asn 
    1850                 1855                 1860             


Phe Ile  Lys Ala Asn Gln Ser  Lys Leu Arg Val Glu  Lys Tyr Ser 
    1865                 1870                 1875             


Gly Leu  Met Asp Tyr Leu Lys  Ser Arg Ser Glu Asn  Asp Asn Val 
    1880                 1885                 1890             


Pro Ile  Gly Lys Met Ile Ile  Leu Pro Ser Ser Phe  Glu Gly Ser 
    1895                 1900                 1905             


Pro Arg  Asn Met Gln Gln Arg  Tyr Gln Asp Ala Met  Ala Ile Val 
    1910                 1915                 1920             


Thr Lys  Tyr Gly Lys Pro Asp  Leu Phe Ile Thr Met  Thr Cys Asn 
    1925                 1930                 1935             


Pro Lys  Trp Ala Asp Ile Thr  Asn Asn Leu Gln Arg  Trp Gln Lys 
    1940                 1945                 1950             


Val Glu  Asn Arg Pro Asp Leu  Val Ala Arg Val Phe  Asn Ile Lys 
    1955                 1960                 1965             


Leu Asn  Ala Leu Leu Asn Asp  Ile Cys Lys Phe His  Leu Phe Gly 
    1970                 1975                 1980             


Lys Val  Ile Ala Lys Ile His  Val Ile Glu Phe Gln  Lys Arg Gly 
    1985                 1990                 1995             


Leu Pro  His Ala His Ile Leu  Leu Ile Leu Asp Ser  Glu Ser Lys 
    2000                 2005                 2010             


Leu Arg  Ser Glu Asp Asp Ile  Asp Arg Ile Val Lys  Ala Glu Ile 
    2015                 2020                 2025             


Pro Asp  Glu Asp Gln Cys Pro  Arg Leu Phe Gln Ile  Val Lys Ser 
    2030                 2035                 2040             


Asn Met  Val His Gly Pro Cys  Gly Ile Gln Asn Pro  Asn Ser Pro 
    2045                 2050                 2055             


Cys Met  Glu Asn Gly Lys Cys  Ser Lys Gly Tyr Pro  Lys Glu Phe 
    2060                 2065                 2070             


Gln Asn  Ala Thr Ile Gly Asn  Ile Asp Gly Tyr Pro  Lys Tyr Lys 
    2075                 2080                 2085             


Arg Arg  Ser Gly Ser Thr Met  Ser Ile Gly Asn Lys  Val Val Asp 
    2090                 2095                 2100             


Asn Thr  Trp Ile Val Pro Tyr  Asn Pro Tyr Leu Cys  Leu Lys Tyr 
    2105                 2110                 2115             


Asn Cys  His Ile Asn Val Glu  Val Cys Ala Ser Ile  Lys Ser Val 
    2120                 2125                 2130             


Lys Tyr  Leu Phe Lys Tyr Ile  Tyr Lys Gly His Asp  Cys Ala Asn 
    2135                 2140                 2145             


Ile Gln  Ile Ser Glu Lys Asn  Ile Ile Asn His Asp  Glu Val Gln 
    2150                 2155                 2160             


Asp Phe  Ile Asp Ser Arg Tyr  Val Ser Ala Pro Glu  Ala Val Trp 
    2165                 2170                 2175             


Arg Leu  Phe Ala Met Arg Met  His Asp Gln Ser His  Ala Ile Thr 
    2180                 2185                 2190             


Arg Leu  Ala Ile His Leu Pro  Asn Asp Gln Asn Leu  Tyr Phe His 
    2195                 2200                 2205             


Thr Asp  Asp Phe Ala Glu Val  Leu Asp Arg Ala Lys  Arg His Asn 
    2210                 2215                 2220             


Ser Thr  Leu Met Ala Trp Phe  Leu Leu Asn Arg Glu  Asp Ser Asp 
    2225                 2230                 2235             


Ala Arg  Asn Tyr Tyr Tyr Trp  Glu Ile Pro Gln His  Tyr Val Phe 
    2240                 2245                 2250             


Asn Asn  Ser Leu Trp Thr Lys  Arg Arg Lys Gly Gly  Asn Lys Val 
    2255                 2260                 2265             


Leu Gly  Arg Leu Phe Thr Val  Ser Phe Arg Glu Pro  Glu Arg Tyr 
    2270                 2275                 2280             


Tyr Leu  Arg Leu Leu Leu Leu  His Val Lys Gly Ala  Ile Ser Phe 
    2285                 2290                 2295             


Glu Asp  Leu Arg Thr Val Gly  Gly Val Thr Tyr Asp  Thr Phe His 
    2300                 2305                 2310             


Glu Ala  Ala Lys His Arg Gly  Leu Leu Leu Asp Asp  Thr Ile Trp 
    2315                 2320                 2325             


Lys Asp  Thr Ile Asp Asp Ala  Ile Ile Leu Asn Met  Pro Lys Gln 
    2330                 2335                 2340             


Leu Arg  Gln Leu Phe Ala Tyr  Ile Cys Val Phe Gly  Cys Pro Ser 
    2345                 2350                 2355             


Ala Ala  Asp Lys Leu Trp Asp  Glu Asn Lys Ser His  Phe Ile Glu 
    2360                 2365                 2370             


Asp Phe  Cys Trp Lys Leu His  Arg Arg Glu Gly Ala  Cys Val Asn 
    2375                 2380                 2385             


Cys Glu  Met His Ala Leu Asn  Glu Ile Gln Glu Val  Phe Thr Leu 
    2390                 2395                 2400             


His Gly  Met Lys Cys Ser His  Phe Lys Leu Pro Asp  Tyr Pro Leu 
    2405                 2410                 2415             


Leu Met  Asn Ala Asn Thr Cys  Asp Gln Leu Tyr Glu  Gln Gln Gln 
    2420                 2425                 2430             


Ala Glu  Val Leu Ile Asn Ser  Leu Asn Asp Glu Gln  Leu Ala Ala 
    2435                 2440                 2445             


Phe Gln  Thr Ile Thr Ser Ala  Ile Glu Asp Gln Thr  Val His Pro 
    2450                 2455                 2460             


Lys Cys  Phe Phe Leu Asp Gly  Pro Gly Gly Ser Gly  Lys Thr Tyr 
    2465                 2470                 2475             


Leu Tyr  Lys Val Leu Thr His  Tyr Ile Arg Gly Arg  Gly Gly Thr 
    2480                 2485                 2490             


Val Leu  Pro Thr Ala Ser Thr  Gly Ile Ala Ala Asn  Leu Leu Leu 
    2495                 2500                 2505             


Gly Gly  Arg Thr Phe His Ser  Gln Tyr Lys Leu Pro  Ile Pro Leu 
    2510                 2515                 2520             


Asn Glu  Thr Ser Ile Ser Arg  Leu Asp Ile Lys Ser  Glu Val Ala 
    2525                 2530                 2535             


Lys Thr  Ile Lys Lys Ala Gln  Leu Leu Ile Ile Asp  Glu Cys Thr 
    2540                 2545                 2550             


Met Ala  Ser Ser His Ala Ile  Asn Ala Ile Asp Arg  Leu Leu Arg 
    2555                 2560                 2565             


Glu Ile  Met Asn Leu Asn Val  Ala Phe Gly Gly Lys  Val Leu Leu 
    2570                 2575                 2580             


Leu Gly  Gly Asp Phe Arg Gln  Cys Leu Ser Ile Val  Pro His Ala 
    2585                 2590                 2595             


Met Arg  Ser Ala Ile Val Gln  Thr Ser Leu Lys Tyr  Cys Asn Val 
    2600                 2605                 2610             


Trp Gly  Cys Phe Arg Lys Leu  Ser Leu Lys Thr Asn  Met Arg Ser 
    2615                 2620                 2625             


Glu Asp  Ser Ala Tyr Ser Glu  Trp Leu Val Lys Leu  Gly Asp Gly 
    2630                 2635                 2640             


Lys Leu  Asp Ser Ser Phe His  Leu Gly Met Asp Ile  Ile Glu Ile 
    2645                 2650                 2655             


Pro His  Glu Met Ile Cys Asn  Gly Ser Ile Ile Glu  Ala Thr Phe 
    2660                 2665                 2670             


Gly Asn  Ser Ile Ser Ile Asp  Asn Ile Lys Asn Ile  Ser Lys Arg 
    2675                 2680                 2685             


Ala Ile  Leu Cys Pro Lys Asn  Glu His Val Gln Lys  Leu Asn Glu 
    2690                 2695                 2700             


Glu Ile  Leu Asp Ile Leu Asp  Gly Asp Phe His Thr  Tyr Leu Ser 
    2705                 2710                 2715             


Asp Asp  Ser Ile Asp Ser Thr  Asp Asp Ala Glu Lys  Glu Asn Phe 
    2720                 2725                 2730             


Pro Ile  Glu Phe Leu Asn Ser  Ile Thr Pro Ser Gly  Met Pro Cys 
    2735                 2740                 2745             


His Lys  Leu Lys Leu Lys Val  Gly Ala Ile Ile Met  Leu Leu Arg 
    2750                 2755                 2760             


Asn Leu  Asn Ser Lys Trp Gly  Leu Cys Asn Gly Thr  Arg Phe Ile 
    2765                 2770                 2775             


Ile Lys  Arg Leu Arg Pro Asn  Ile Ile Glu Ala Glu  Val Leu Thr 
    2780                 2785                 2790             


Gly Ser  Ala Glu Gly Glu Val  Val Leu Ile Pro Arg  Ile Asp Leu 
    2795                 2800                 2805             


Ser Pro  Ser Asp Thr Gly Leu  Pro Phe Lys Leu Ile  Arg Arg Gln 
    2810                 2815                 2820             


Phe Pro  Val Met Pro Ala Phe  Ala Met Thr Ile Asn  Lys Ser Gln 
    2825                 2830                 2835             


Gly Gln  Thr Leu Asp Arg Val  Gly Ile Phe Leu Pro  Glu Pro Val 
    2840                 2845                 2850             


Phe Ala  His Gly Gln Leu Tyr  Val Ala Phe Ser Arg  Val Arg Arg 
    2855                 2860                 2865             


Ala Cys  Asp Val Lys Val Lys  Val Val Asn Thr Ser  Ser Gln Gly 
    2870                 2875                 2880             


Lys Leu  Val Lys His Ser Glu  Ser Val Phe Thr Leu  Asn Val Val 
    2885                 2890                 2895             


Tyr Arg  Glu Ile Leu Glu 
    2900                 


<210>  54
<211>  150
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  54
tcctatataa taaaagagaa acatgcaaat tgaccatccc tccgctacgc tcaagccacg       60

cccaccagcc aatcagaagt gactatgcaa attaacccaa caaagatggc agttaaattt      120

gcatacgcag gtgtcaagcg ccccaggagg                                       150


<210>  55
<211>  150
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  55
aaatttatgt attattttca tatacatttt actcatttcc tttcatctct cacacttcta       60

ttatagagaa agggcaaata gcaatattaa aatatttcct ctaattaatt ccctttcaat      120

gtgcacgaat ttcgtgcacc gggccactag                                       150


<210>  56
<211>  162
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  56
caattcccct gtagaaataa ttttgtttaa ctttaataag gagatatacc atgatatata       60

tatagcgtag ctagggatcc gaattcgagc tcggcgcgct cctatataat aaaagagaaa      120

catgcaaatt gaccatccct ccgctacgct caagccacgc cc                         162


<210>  57
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  57
tttaataagg agatatacca tgatatatat atatgcgtag ctagggatcc gaatt            55


<210>  58
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  58
gaccatccct                                                              10


<210>  59
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  59
tttaataagg agatatacca tgatatatat atatgcgtag ctag                        44


<210>  60
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  60
tataataaaa gagaaacatg caaattgacc atccct                                 36


<210>  61
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  61
tttaataagg agatatacca tgatatatat atatgcgtag ctagggatcc gaattcgagc       60

tcggcg                                                                  66


<210>  62
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  62
ttgaccatcc ct                                                           12


<210>  63
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  63
tttaataagg agatatacca tgatatatat atatgcgtag ctagggatcc gaattcgag        59


<210>  64
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  64
tttaataagg agatatacca tgatatatat atatgcgtag ctagggatcc gaattcgagc       60

tcg                                                                     63


<210>  65
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  65
taataaaaga gaaacatgca aattgaccat ccct                                   34


<210>  66
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  66
ttaataagga gatataccat gatatatata tatgcgtagc tagggatccg aa               52


<210>  67
<211>  68
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  67
tttaataagg agatatacca tgatatatat atatgcgtag ctagggatcc gaattcgagc       60

tcggcgcg                                                                68


<210>  68
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  68
tgcaaattga ccatccct                                                     18


<210>  69
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  69
tttaataagg agatatacca tgatatatat atatgcgtag ctagggatcc gaattcgagc       60

t                                                                       61


<210>  70
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  70
tcctatataa taaaagagaa acatgcaaat tgaccatccc t                           41


<210>  71
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  71
taaaagagaa acatgcaaat tgaccatccc t                                      31


<210>  72
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  72
tttaataagg agatatacca tgatatatat atatgcgtag ctagggatcc gaattcgagc       60

tcgg                                                                    64


<210>  73
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  73
tttaataagg agatatacca tgatatatat atatgcgtag ctagggatcc g                51


<210>  74
<211>  68
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  74
tttaataagg agatatacca tgatatatat atatgcgtag ctagggatcc gaattcgagc       60

tcggcgcg                                                                68


<210>  75
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  75
tttaataagg agatatacca tgatatatat atatgcgtag ctagggatcc gaattcgagc       60

tcggcgcgtc ctatataata aaagagaaac atgcaaattg accatccct                  109


<210>  76
<211>  150
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  76
caatgtgcac gaatttcgtg caccgggcca ctagtgaatt cactggccgt caattcccct       60

gtagaaataa ttttgtttaa ctttaataag gagatatacc atgatatata tatatgcgta      120

gctagggatc cgaattcgag ctcggcgcgc                                       150


<210>  77
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  77
ggccactagt                                                              10


<210>  78
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  78
ggccactagt ga                                                           12


<210>  79
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  79
ggccactagt gaattcactg g                                                 21


<210>  80
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  80
ggccactagt gaatt                                                        15


<210>  81
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  81
ggccactagt g                                                            11


<210>  82
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  82
ggccactagt gaattcact                                                    19


<210>  83
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  83
ggccactagt cct                                                          13


<210>  84
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  84
atataccatg atatatcgat taaatacgat cgggatccga attcgagctc ggcgcgcctg       60


<210>  85
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  85
ttcgagctcg tt                                                           12


<210>  86
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  86
tatgcgtagc tagggatccg aatt                                              24


<210>  87
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  87
atataccatg atatatcgat taaatacgat cgggatccga attcgagctc ggcgcgcctg       60


<210>  88
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  88
atataccatg gctactatat atgacgtcaa tgggatccga attcgagctc ggcgcgcctg       60


<210>  89
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  89
atataccatg gtaacgaagt acggcgtagc agggatccga attcgagctc ggcgcgcctg       60


<210>  90
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  90
atataccatg atatatcgat taaatacgat cgggatccga attcgagctc ggcgcgcctg       60


<210>  91
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  91
atataccatg atatatcgat taaatacgat cgggatccga attcgagctc ggcgcgcctg       60


<210>  92
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  92
tttaataagg agatatacca tgatatatat atatgcgtag ctagggatcc gaattcgagc       60

tcggcgcgcc tgcaggtcga caag                                              84


<210>  93
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  93
tttaataagg agatatacca tgatatatcg attaaatacg atcgggatcc gaattcgagc       60

tcggcgcgcc tgcaggtcga caag                                              84


<210>  94
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  94
tttaataagg agatatacca tggctactat atatgacgtc aatgggatcc gaattcgagc       60

tcggcgcgcc tgcaggtcga caag                                              84


<210>  95
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  95
tttaataagg agatatacca tgatatatat atatgcgtag ctagggatcc gaattcgagc       60

tcggcgcgcc tgcaggtcga caag                                              84


<210>  96
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  96
tttaataagg agatatacca tgatatatcg attaaatacg atcgggatcc gaattcgagc       60

tcggcgcgcc tgcaggtcga caag                                              84


<210>  97
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  97
tttaataagg agatatacca tgatatatat atatgcgtag ctagggatcc gaattcgagc       60

tcggcgcgcc tgcaggtcga caag                                              84


<210>  98
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  98
tttaataagg agatatacca tgatatatcg attaaatacg atcgggatcc gaattcgagc       60

tcggcgcgcc tgcaggtcga caag                                              84


<210>  99
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  99
tttaataagg agatatacca tgatatatat atatgcgtag ctagggatcc gaattcgagc       60

tcggcgcgcc tgcaggtcga caag                                              84


<210>  100
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  100
tttaataagg agatatacca tgatatatcg attaaatacg atcgggatcc gaattcgagc       60

tcggcgcgcc tgcaggtcga caag                                              84


<210>  101
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  101
ttaataagga gatataccat gatatatcga tta                                    33


<210>  102
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  102
atccctccgc tacgctcaag ccacgc                                            26


<210>  103
<211>  164
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  103
ttaataagga gatataccat gatatatcga ttaaatacga tcgggatccg aattcgagct       60

cggcgcgcct gcagtgcacg aatttcgtgc accgggccac tagtcctata taataaaaga      120

gaaacatgca aattgaccat ccctccgcta cgctcaagcc acgc                       164


<210>  104
<211>  79
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  104
ttaataagga gatataccat gatatatcga ttaaatacga tcgggatccg aattcgagct       60

cggcgcgcct gcaggtcga                                                    79


<210>  105
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  105
ttaataagga gatataccat gatatatcga ttaaatacga tcgggatccg                  50


<210>  106
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  106
ttaataagga gatataccat                                                   20


<210>  107
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  107
ttaataagga gatataccat gatatatcga ttaaatacga tcgggatccg aattcgagct       60

cggcgcgcc                                                               69


<210>  108
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  108
ttaataagga gatataccat gatata                                            26


<210>  109
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  109
ttaataagga gatataccat gatatatcga ttaaatacga tcgggatccg aattcgagct       60

c                                                                       61


<210>  110
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  110
ttaataagga gatataccat gatatatcga tta                                    33


<210>  111
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  111
ttaataagga gatataccat ga                                                22


<210>  112
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  112
ttaataagga gatataccat gatatatcga ttaaata                                37


<210>  113
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  113
ttaataagga gatataccat gatatatcga t                                      31


<210>  114
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  114
ttaataagga gatataccat gatatatcga ttaaatacga tcgggatccg aattcgagct       60

cg                                                                      62


<210>  115
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  115
ttaataagga gatataccat gatatatcga ttaaatacga tc                          42


<210>  116
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  116
ttaataagga gatataccat gata                                              24


<210>  117
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  117
ttaataagga gatatacca                                                    19


<210>  118
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  118
ttaataagga gatataccat gatatatcga ttaaatac                               38


<210>  119
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  119
ttaataagga gatataccat gatatatcga tt                                     32


<210>  120
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  120
ttaataagga gatataccat gatatatcga                                        30


<210>  121
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  121
ttaataagga gatataccat gatatatcga ttaa                                   34


<210>  122
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  122
ttaataagga gatataccat gatata                                            26


<210>  123
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  123
ttaataagga gatataccat gatatatcga ttaaat                                 36


<210>  124
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  124
ttaataagga gatataccat gatatatcga tta                                    33


<210>  125
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  125
ttaataagga gatataccat gatatatcga ttaaa                                  35


<210>  126
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  126
ttaataagga gatataccat gatatatcga ttaaata                                37


<210>  127
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  127
ttaataagga gatataccat gatatatcga ttaaatacga tcggg                       45


<210>  128
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  128
ttaataagga gatataccat gatatatcga ttaaatacg                              39


<210>  129
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  129
ttaataagga gatataccat gata                                              24


<210>  130
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  130
ttaataagga                                                              10


<210>  131
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  131
ttaataagga gatatac                                                      17


<210>  132
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  132
ttaataagga gat                                                          13


<210>  133
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  133
ttaataagga g                                                            11


<210>  134
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  134
ttaataagga gatataccat gatatatcga ttaaatacga tcgggatccg aa               52


<210>  135
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  135
ttaataagga gatataccat gatatatcga ttaaatacga tcg                         43


<210>  136
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  136
ttaataagga gatataccat gat                                               23


<210>  137
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  137
ttaataagga gatataccat gatatatcga ttaaatacga tcgggatcc                   49


<210>  138
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  138
ttaataagga gatataccat gatatatcga ttaaatacga tcgg                        44


<210>  139
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  139
ttaataagga gatataccat gatat                                             25


<210>  140
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  140
ttaataagga gatataccat gatatatcga ttaaatacga                             40


<210>  141
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  141
ttaataagga gatataccat                                                   20


<210>  142
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  142
ttaataagga gatataccat gatatatcga ttaaatac                               38


<210>  143
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  143
ttaataagga gatataccat g                                                 21


<210>  144
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  144
ttaataagga gatataccat ga                                                22


<210>  145
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  145
ttaataagga gatatacca                                                    19


<210>  146
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  146
ttaataagga gatataccat gatatatcga t                                      31


<210>  147
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  147
ttaataagga ga                                                           12


<210>  148
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  148
ttaataagga gata                                                         14


<210>  149
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  149
ttaataagga gatataccat gatatatcg                                         29


<210>  150
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  150
ttaataagga gatataccat gatatatcga ttaaat                                 36


<210>  151
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  151
ttaataagga gatataccat gatatatcga tt                                     32


<210>  152
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  152
ttaataagga gatataccat gatatatcga tta                                    33


<210>  153
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  153
ttaataagga gatataccat gatatatcga                                        30


<210>  154
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  154
ttaataagga gatataccat gatatatcga ttaa                                   34


<210>  155
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  155
ttaataagga gatataccat gatata                                            26


<210>  156
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  156
ttaataagga gatataccat gatatatcga ttaaa                                  35


<210>  157
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  157
tcaagccacg c                                                            11


<210>  158
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  158
tccgctacgc tcaagccacg c                                                 21


<210>  159
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  159
tccctccgct acgctcaagc cacgc                                             25


<210>  160
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  160
tcctatataa taaaagagaa acatgcaaat tgaccatccc tccgctacgc tcaagccacg       60

c                                                                       61


<210>  161
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  161
tttatatgtt gtaatatttc ttcaaataaa tctctcctat aaaccaccct gggtgggtat       60

tcgtgatttg cacgggactt ctggctgagg tcagacagga                            100


<210>  162
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  162
agagtaggct ggtagatgga gttgggtttg gtgctcaatg aaaggagata aggtccttga       60

attgcagtat ctagcctctt ctaagacagg ttacgtgatg                            100


<210>  163
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  163
atataccatg atatatcgat taaatacgat cgggatccga attcgagctc ggcgcgcctg       60


<210>  164
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  164
atataccatg gctactatat atgacgtcaa tgggatccga attcgagctc ggcgcgcctg       60


<210>  165
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  165
atataccatg gtaacgaagt acggcgtagc agggatccga attcgagctc ggcgcgcctg       60


<210>  166
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  166
acagcaaaag aaactaccat cagagtgaac aggcaaccta caacatggga gaaaattttc       60


<210>  167
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  167
accaaacacc gcatattctc actcataggt gggaattgaa caatgagatc acatggacac       60


<210>  168
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  168
tcttaatcca gtctatcatt gttggacatt tgggttggtt ccaagtcttt gctattgtga       60


<210>  169
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  169
tttatatgtt gtaatatttc ttcaaataaa tctctcctat aaaccaccct gggtgggtat       60

tcgtgatttg cacgggactt ctggctgagg tcagacagga                            100


<210>  170
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  170
tttatatgtt gtaatatttc ttcaaataaa tctctcctat aaaccaccct gggtgggtat       60

tcgtgatttg cacgggactt ctggctgagg tcagacagga                            100


<210>  171
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  171
tttatatgtt gtaatatttc ttcaaataaa tctctcctat aaaccaccct gggtgggtat       60

tcgtgatttg cacgggactt ctggctgagg tcagacagga                            100


<210>  172
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  172
caaggggatt ctcccctcat ttccaagccc atagcctgca catctcacct aggccggccg       60

tggaggatgg cagaggctct gggcacaggc tgctggactc                            100


<210>  173
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  173
agagtaggct ggtagatgga gttgggtttg gtgctcaatg aaaggagata aggtccttga       60

attgcagtat ctagcctctt ctaagacagg ttacgtgatg                            100


