                         SEQUENCE LISTING

<110>  Takeda Vaccines, Inc.
 
<120>  METHODS FOR DETERMINING COMPLEMENT-FIXING ANTIBODIES

<130>  T08507WO

<150>  EP20201091
<151>  2020-10-09

<150>  US 63/212,194
<151>  2021-06-18

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  3392
<212>  PRT
<213>  Dengue virus serotype 1

<400>  1

Met Asn Asn Gln Arg Lys Lys Thr Gly Arg Pro Ser Phe Asn Met Leu 
1               5                   10                  15      


Lys Arg Ala Arg Asn Arg Val Ser Thr Gly Ser Gln Leu Ala Lys Arg 
            20                  25                  30          


Phe Ser Lys Gly Leu Leu Ser Gly Gln Gly Pro Met Lys Leu Val Met 
        35                  40                  45              


Ala Phe Ile Ala Phe Leu Arg Phe Leu Ala Ile Pro Pro Thr Ala Gly 
    50                  55                  60                  


Ile Leu Ala Arg Trp Ser Ser Phe Lys Lys Asn Gly Ala Ile Lys Val 
65                  70                  75                  80  


Leu Arg Gly Phe Lys Lys Glu Ile Ser Ser Met Leu Asn Ile Met Asn 
                85                  90                  95      


Arg Arg Lys Lys Ser Val Thr Met Leu Leu Met Leu Leu Pro Thr Ala 
            100                 105                 110         


Leu Ala Phe His Leu Thr Thr Arg Gly Gly Glu Pro His Met Ile Val 
        115                 120                 125             


Ser Lys Gln Glu Arg Gly Lys Ser Leu Leu Phe Lys Thr Ser Ala Gly 
    130                 135                 140                 


Ile Asn Met Cys Thr Leu Ile Ala Met Asp Leu Gly Glu Leu Cys Glu 
145                 150                 155                 160 


Asp Thr Met Thr Tyr Lys Cys Pro Arg Ile Thr Glu Ala Glu Pro Asp 
                165                 170                 175     


Asp Val Asp Cys Trp Cys Asn Ala Thr Asp Thr Trp Val Thr Tyr Gly 
            180                 185                 190         


Thr Cys Ser Gln Thr Gly Glu His Arg Arg Asp Lys Arg Ser Val Ala 
        195                 200                 205             


Leu Ala Pro His Val Gly Leu Gly Leu Glu Thr Arg Thr Glu Thr Trp 
    210                 215                 220                 


Met Ser Ser Glu Gly Ala Trp Lys Gln Ile Gln Lys Val Glu Thr Trp 
225                 230                 235                 240 


Ala Leu Arg His Pro Gly Phe Thr Val Thr Ala Leu Phe Leu Ala His 
                245                 250                 255     


Ala Ile Gly Thr Ser Ile Thr Gln Lys Gly Ile Ile Phe Ile Leu Leu 
            260                 265                 270         


Met Leu Val Thr Pro Ser Met Ala Met Arg Cys Val Gly Ile Gly Asn 
        275                 280                 285             


Arg Asp Phe Val Glu Gly Leu Ser Gly Ala Thr Trp Val Asp Val Val 
    290                 295                 300                 


Leu Glu His Gly Ser Cys Val Thr Thr Met Ala Lys Asp Lys Pro Thr 
305                 310                 315                 320 


Leu Asp Ile Glu Leu Leu Lys Thr Glu Val Thr Asn Pro Ala Val Leu 
                325                 330                 335     


Arg Lys Leu Cys Ile Glu Ala Lys Ile Ser Asn Thr Thr Thr Asp Ser 
            340                 345                 350         


Arg Cys Pro Thr Gln Gly Glu Ala Thr Leu Val Glu Glu Gln Asp Ser 
        355                 360                 365             


Asn Phe Val Cys Arg Arg Thr Phe Val Asp Arg Gly Trp Gly Asn Gly 
    370                 375                 380                 


Cys Gly Leu Phe Gly Lys Gly Ser Leu Leu Thr Cys Ala Lys Phe Lys 
385                 390                 395                 400 


Cys Val Thr Lys Leu Glu Gly Lys Ile Val Gln Tyr Glu Asn Leu Lys 
                405                 410                 415     


Tyr Ser Val Ile Val Thr Val His Thr Gly Asp Gln His Gln Val Gly 
            420                 425                 430         


Asn Glu Thr Thr Glu His Gly Thr Ile Ala Thr Ile Thr Pro Gln Ala 
        435                 440                 445             


Pro Thr Ser Glu Ile Gln Leu Thr Asp Tyr Gly Ala Leu Thr Leu Asp 
    450                 455                 460                 


Cys Ser Pro Arg Thr Gly Leu Asp Phe Asn Glu Met Val Leu Leu Thr 
465                 470                 475                 480 


Met Lys Glu Lys Ser Trp Leu Val His Lys Gln Trp Phe Leu Asp Leu 
                485                 490                 495     


Pro Leu Pro Trp Thr Ser Gly Ala Ser Thr Ser Gln Glu Thr Trp Asn 
            500                 505                 510         


Arg Gln Asp Leu Leu Val Thr Phe Lys Thr Ala His Ala Lys Lys Gln 
        515                 520                 525             


Glu Val Val Val Leu Gly Ser Gln Glu Gly Ala Met His Thr Ala Leu 
    530                 535                 540                 


Thr Gly Ala Thr Glu Ile Gln Thr Ser Gly Thr Thr Thr Ile Phe Ala 
545                 550                 555                 560 


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Thr Leu Lys Gly 
                565                 570                 575     


Met Ser Tyr Val Met Cys Thr Gly Ser Phe Lys Leu Glu Lys Glu Val 
            580                 585                 590         


Ala Glu Thr Gln His Gly Thr Val Leu Val Gln Val Lys Tyr Glu Gly 
        595                 600                 605             


Thr Asp Ala Pro Cys Lys Ile Pro Phe Ser Ala Gln Asp Glu Lys Gly 
    610                 615                 620                 


Val Thr Gln Asn Gly Arg Leu Ile Thr Ala Asn Pro Ile Val Thr Asp 
625                 630                 635                 640 


Lys Glu Lys Pro Val Asn Ile Glu Thr Glu Pro Pro Phe Gly Glu Ser 
                645                 650                 655     


Tyr Ile Val Val Gly Ala Gly Glu Lys Ala Leu Lys Leu Ser Trp Phe 
            660                 665                 670         


Lys Lys Gly Ser Ser Ile Gly Lys Met Phe Glu Ala Thr Ala Arg Gly 
        675                 680                 685             


Ala Arg Arg Met Ala Ile Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser 
    690                 695                 700                 


Ile Gly Gly Val Phe Thr Ser Val Gly Lys Leu Val His Gln Val Phe 
705                 710                 715                 720 


Gly Ala Ala Tyr Gly Val Leu Phe Ser Gly Val Ser Trp Thr Met Lys 
                725                 730                 735     


Ile Gly Ile Gly Ile Leu Leu Thr Trp Leu Gly Leu Asn Ser Arg Ser 
            740                 745                 750         


Thr Ser Leu Ser Met Thr Cys Ile Ala Val Gly Met Val Thr Leu Tyr 
        755                 760                 765             


Leu Gly Val Met Val Gln Ala Asp Ser Gly Cys Val Ile Asn Trp Lys 
    770                 775                 780                 


Gly Arg Glu Leu Lys Cys Gly Ser Gly Ile Phe Val Thr Asn Glu Val 
785                 790                 795                 800 


His Thr Trp Thr Glu Gln Tyr Lys Phe Gln Ala Asp Ser Pro Lys Arg 
                805                 810                 815     


Leu Ser Ala Ala Ile Gly Lys Ala Trp Glu Glu Gly Val Cys Gly Ile 
            820                 825                 830         


Arg Ser Ala Thr Arg Leu Glu Asn Ile Met Trp Lys Gln Ile Ser Asn 
        835                 840                 845             


Glu Leu Asn His Ile Leu Leu Glu Asn Asp Met Lys Phe Thr Val Val 
    850                 855                 860                 


Val Gly Asp Ala Asn Gly Ile Leu Ala Gln Gly Lys Lys Met Ile Arg 
865                 870                 875                 880 


Pro Gln Pro Met Glu His Arg Tyr Ser Trp Lys Ser Trp Gly Lys Ala 
                885                 890                 895     


Lys Ile Ile Gly Ala Asp Ile Gln Asn Ser Thr Phe Ile Ile Asp Gly 
            900                 905                 910         


Pro Asp Thr Pro Glu Cys Pro Asp Asp Gln Arg Ala Trp Asn Ile Trp 
        915                 920                 925             


Glu Val Glu Asp Tyr Gly Phe Gly Ile Phe Thr Thr Asn Ile Trp Leu 
    930                 935                 940                 


Lys Leu Arg Asp Ser Tyr Thr Gln Met Cys Asp His Arg Leu Met Ser 
945                 950                 955                 960 


Ala Ala Ile Lys Asp Ser Lys Ala Val His Ala Asp Met Gly Tyr Trp 
                965                 970                 975     


Ile Glu Ser Glu Lys Asn Glu Thr Trp Lys Leu Ala Arg Ala Ser Phe 
            980                 985                 990         


Ile Glu Val Lys Thr Cys Ile Trp  Pro Lys Ser His Thr  Leu Trp Ser 
        995                 1000                 1005             


Asn Gly  Val Leu Glu Ser Glu  Met Ile Ile Pro Lys  Ile Tyr Gly 
    1010                 1015                 1020             


Gly Pro  Ile Ser Gln His Asn  Tyr Arg Pro Gly Tyr  Phe Thr Gln 
    1025                 1030                 1035             


Thr Ala  Gly Pro Trp His Leu  Gly Lys Leu Glu Leu  Asp Phe Asp 
    1040                 1045                 1050             


Leu Cys  Glu Gly Thr Thr Val  Val Val Asp Glu His  Cys Gly Asn 
    1055                 1060                 1065             


Arg Gly  Pro Ser Leu Arg Thr  Thr Thr Val Thr Gly  Lys Ile Ile 
    1070                 1075                 1080             


His Glu  Trp Cys Cys Arg Ser  Cys Thr Leu Pro Pro  Leu Arg Phe 
    1085                 1090                 1095             


Arg Gly  Glu Asp Gly Cys Trp  Tyr Gly Met Glu Ile  Arg Pro Val 
    1100                 1105                 1110             


Lys Glu  Lys Glu Glu Asn Leu  Val Arg Ser Met Val  Ser Ala Gly 
    1115                 1120                 1125             


Ser Gly  Glu Val Asp Ser Phe  Ser Leu Gly Ile Leu  Cys Val Ser 
    1130                 1135                 1140             


Ile Met  Ile Glu Glu Val Met  Arg Ser Arg Trp Ser  Arg Lys Met 
    1145                 1150                 1155             


Leu Met  Thr Gly Thr Leu Ala  Val Phe Leu Leu Leu  Ile Met Gly 
    1160                 1165                 1170             


Gln Leu  Thr Trp Asn Asp Leu  Ile Arg Leu Cys Ile  Met Val Gly 
    1175                 1180                 1185             


Ala Asn  Ala Ser Asp Arg Met  Gly Met Gly Thr Thr  Tyr Leu Ala 
    1190                 1195                 1200             


Leu Met  Ala Thr Phe Lys Met  Arg Pro Met Phe Ala  Val Gly Leu 
    1205                 1210                 1215             


Leu Phe  Arg Arg Leu Thr Ser  Arg Glu Val Leu Leu  Leu Thr Ile 
    1220                 1225                 1230             


Gly Leu  Ser Leu Val Ala Ser  Val Glu Leu Pro Asn  Ser Leu Glu 
    1235                 1240                 1245             


Glu Leu  Gly Asp Gly Leu Ala  Met Gly Ile Met Met  Leu Lys Leu 
    1250                 1255                 1260             


Leu Thr  Glu Phe Gln Pro His  Gln Leu Trp Thr Thr  Leu Leu Ser 
    1265                 1270                 1275             


Leu Thr  Phe Ile Lys Thr Thr  Leu Ser Leu Asp Tyr  Ala Trp Arg 
    1280                 1285                 1290             


Thr Met  Ala Met Val Leu Ser  Ile Val Ser Leu Phe  Pro Leu Cys 
    1295                 1300                 1305             


Leu Ser  Thr Thr Ser Gln Lys  Thr Thr Trp Leu Pro  Val Leu Leu 
    1310                 1315                 1320             


Gly Ser  Phe Gly Cys Lys Pro  Leu Thr Met Phe Leu  Ile Thr Glu 
    1325                 1330                 1335             


Asn Lys  Ile Trp Gly Arg Lys  Ser Trp Pro Leu Asn  Glu Gly Ile 
    1340                 1345                 1350             


Met Ala  Ile Gly Ile Val Ser  Ile Leu Leu Ser Ser  Leu Leu Lys 
    1355                 1360                 1365             


Asn Asp  Val Pro Leu Ala Gly  Pro Leu Ile Ala Gly  Gly Met Leu 
    1370                 1375                 1380             


Ile Ala  Cys Tyr Val Ile Ser  Gly Ser Ser Ala Asp  Leu Ser Leu 
    1385                 1390                 1395             


Glu Lys  Ala Ala Glu Val Ser  Trp Glu Glu Glu Ala  Glu His Ser 
    1400                 1405                 1410             


Gly Thr  Ser His Asn Ile Leu  Val Glu Val Gln Asp  Asp Gly Thr 
    1415                 1420                 1425             


Met Lys  Ile Lys Asp Glu Glu  Arg Asp Asp Thr Leu  Thr Ile Leu 
    1430                 1435                 1440             


Leu Lys  Ala Thr Leu Leu Ala  Val Ser Gly Val Tyr  Pro Met Ser 
    1445                 1450                 1455             


Ile Pro  Ala Thr Leu Phe Val  Trp Tyr Phe Trp Gln  Lys Lys Lys 
    1460                 1465                 1470             


Gln Arg  Ser Gly Val Leu Trp  Asp Thr Pro Ser Pro  Pro Glu Val 
    1475                 1480                 1485             


Glu Arg  Ala Val Leu Asp Asp  Gly Ile Tyr Arg Ile  Leu Gln Arg 
    1490                 1495                 1500             


Gly Leu  Leu Gly Arg Ser Gln  Val Gly Val Gly Val  Phe Gln Asp 
    1505                 1510                 1515             


Gly Val  Phe His Thr Met Trp  His Val Thr Arg Gly  Ala Val Leu 
    1520                 1525                 1530             


Met Tyr  Gln Gly Lys Arg Leu  Glu Pro Ser Trp Ala  Ser Val Lys 
    1535                 1540                 1545             


Lys Asp  Leu Ile Ser Tyr Gly  Gly Gly Trp Arg Phe  Gln Gly Ser 
    1550                 1555                 1560             


Trp Asn  Thr Gly Glu Glu Val  Gln Val Ile Ala Val  Glu Pro Gly 
    1565                 1570                 1575             


Lys Asn  Pro Lys Asn Val Gln  Thr Thr Pro Gly Thr  Phe Lys Thr 
    1580                 1585                 1590             


Pro Glu  Gly Glu Val Gly Ala  Ile Ala Leu Asp Phe  Lys Pro Gly 
    1595                 1600                 1605             


Thr Ser  Gly Ser Pro Ile Val  Asn Arg Glu Gly Lys  Ile Val Gly 
    1610                 1615                 1620             


Leu Tyr  Gly Asn Gly Val Val  Thr Thr Ser Gly Thr  Tyr Val Ser 
    1625                 1630                 1635             


Ala Ile  Ala Gln Ala Lys Thr  Ser Gln Glu Gly Pro  Leu Pro Glu 
    1640                 1645                 1650             


Ile Glu  Glu Glu Val Phe Lys  Lys Arg Asn Leu Thr  Ile Met Asp 
    1655                 1660                 1665             


Leu His  Pro Gly Ser Gly Lys  Thr Arg Arg Tyr Leu  Pro Ala Ile 
    1670                 1675                 1680             


Val Arg  Glu Ala Ile Lys Arg  Lys Leu Arg Thr Leu  Ile Leu Ala 
    1685                 1690                 1695             


Pro Thr  Arg Val Val Ala Ser  Glu Met Ala Glu Ala  Leu Lys Gly 
    1700                 1705                 1710             


Met Pro  Ile Arg Tyr Gln Thr  Thr Ala Val Lys Ser  Glu His Thr 
    1715                 1720                 1725             


Gly Arg  Glu Ile Val Asp Leu  Met Cys His Ala Thr  Phe Thr Met 
    1730                 1735                 1740             


Arg Leu  Leu Ser Pro Val Arg  Val Pro Asn Tyr Asn  Met Ile Ile 
    1745                 1750                 1755             


Met Asp  Glu Ala His Phe Thr  Asp Pro Ala Ser Ile  Ala Ala Arg 
    1760                 1765                 1770             


Gly Tyr  Ile Ser Thr Arg Val  Gly Met Gly Glu Ala  Ala Ala Ile 
    1775                 1780                 1785             


Phe Met  Thr Ala Thr Pro Pro  Gly Ser Val Glu Ala  Phe Pro Gln 
    1790                 1795                 1800             


Ser Asn  Ala Val Ile Gln Asp  Glu Glu Arg Asp Ile  Pro Glu Arg 
    1805                 1810                 1815             


Ser Trp  Asn Ser Gly Tyr Asp  Trp Ile Thr Asp Phe  Pro Gly Lys 
    1820                 1825                 1830             


Thr Val  Trp Phe Val Pro Ser  Ile Lys Ser Gly Asn  Asp Ile Ala 
    1835                 1840                 1845             


Asn Cys  Leu Arg Lys Asn Gly  Lys Arg Val Ile Gln  Leu Ser Arg 
    1850                 1855                 1860             


Lys Thr  Phe Asp Thr Glu Tyr  Gln Lys Thr Arg Asn  Asn Asp Trp 
    1865                 1870                 1875             


Asp Tyr  Val Val Thr Thr Asp  Ile Ser Glu Met Gly  Ala Asn Phe 
    1880                 1885                 1890             


Arg Ala  Asp Arg Val Ile Asp  Pro Arg Arg Cys Leu  Lys Pro Val 
    1895                 1900                 1905             


Ile Leu  Lys Asp Gly Pro Glu  Arg Val Ile Leu Ala  Gly Pro Met 
    1910                 1915                 1920             


Pro Val  Thr Val Ala Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly 
    1925                 1930                 1935             


Arg Asn  Gln Asn Lys Glu Gly  Asp Gln Tyr Val Tyr  Met Gly Gln 
    1940                 1945                 1950             


Pro Leu  Asn Asn Asp Glu Asp  His Ala His Trp Thr  Glu Ala Lys 
    1955                 1960                 1965             


Met Leu  Leu Asp Asn Ile Asn  Thr Pro Glu Gly Ile  Ile Pro Ala 
    1970                 1975                 1980             


Leu Phe  Glu Pro Glu Arg Glu  Lys Ser Ala Ala Ile  Asp Gly Glu 
    1985                 1990                 1995             


Tyr Arg  Leu Arg Gly Glu Ala  Arg Lys Thr Phe Val  Glu Leu Met 
    2000                 2005                 2010             


Arg Arg  Gly Asp Leu Pro Val  Trp Leu Ser Tyr Lys  Val Ala Ser 
    2015                 2020                 2025             


Glu Gly  Phe Gln Tyr Ser Asp  Arg Arg Trp Cys Phe  Asp Gly Glu 
    2030                 2035                 2040             


Arg Asn  Asn Gln Val Leu Glu  Glu Asn Met Asp Val  Glu Ile Trp 
    2045                 2050                 2055             


Thr Lys  Glu Gly Glu Arg Lys  Lys Leu Arg Pro Arg  Trp Leu Asp 
    2060                 2065                 2070             


Ala Arg  Thr Tyr Ser Asp Pro  Leu Ala Leu Arg Glu  Phe Lys Glu 
    2075                 2080                 2085             


Phe Ala  Ala Gly Arg Arg Ser  Val Ser Gly Asp Leu  Ile Leu Glu 
    2090                 2095                 2100             


Ile Gly  Lys Leu Pro Gln His  Leu Thr Leu Arg Ala  Gln Asn Ala 
    2105                 2110                 2115             


Leu Asp  Asn Leu Val Met Leu  His Asn Ser Glu Gln  Gly Gly Lys 
    2120                 2125                 2130             


Ala Tyr  Arg His Ala Met Glu  Glu Leu Pro Asp Thr  Ile Glu Thr 
    2135                 2140                 2145             


Leu Met  Leu Leu Ala Leu Ile  Ala Val Leu Thr Gly  Gly Val Thr 
    2150                 2155                 2160             


Leu Phe  Phe Leu Ser Gly Lys  Gly Leu Gly Lys Thr  Ser Ile Gly 
    2165                 2170                 2175             


Leu Leu  Cys Val Met Ala Ser  Ser Ala Leu Leu Trp  Met Ala Asn 
    2180                 2185                 2190             


Val Glu  Pro His Trp Ile Ala  Ala Ser Ile Ile Leu  Glu Phe Phe 
    2195                 2200                 2205             


Leu Met  Val Leu Leu Ile Pro  Glu Pro Asp Arg Gln  Arg Thr Pro 
    2210                 2215                 2220             


Gln Asp  Asn Gln Leu Ala Tyr  Val Val Ile Gly Leu  Leu Phe Met 
    2225                 2230                 2235             


Ile Leu  Thr Val Ala Ala Asn  Glu Met Gly Leu Leu  Glu Thr Thr 
    2240                 2245                 2250             


Lys Lys  Asp Leu Gly Ile Gly  Tyr Val Ala Ala Glu  Asn Gln His 
    2255                 2260                 2265             


His Ala  Thr Met Leu Asp Val  Asp Leu Arg Pro Ala  Ser Ala Trp 
    2270                 2275                 2280             


Thr Leu  Tyr Ala Val Ala Thr  Thr Val Ile Thr Pro  Met Met Arg 
    2285                 2290                 2295             


His Thr  Ile Glu Asn Thr Thr  Ala Asn Ile Ser Leu  Thr Ala Ile 
    2300                 2305                 2310             


Ala Asn  Gln Ala Ala Ile Leu  Met Gly Leu Asp Lys  Gly Trp Pro 
    2315                 2320                 2325             


Ile Ser  Lys Met Asp Ile Gly  Val Pro Leu Leu Ala  Leu Gly Cys 
    2330                 2335                 2340             


Tyr Ser  Gln Val Asn Pro Leu  Thr Leu Thr Ala Ala  Val Leu Met 
    2345                 2350                 2355             


Leu Val  Ala His Tyr Ala Ile  Ile Gly Pro Gly Leu  Gln Ala Lys 
    2360                 2365                 2370             


Ala Thr  Arg Glu Ala Gln Lys  Arg Thr Ala Ala Gly  Ile Met Lys 
    2375                 2380                 2385             


Asn Pro  Thr Val Asp Gly Ile  Val Ala Ile Asp Leu  Asp Pro Val 
    2390                 2395                 2400             


Val Tyr  Asp Ala Lys Phe Glu  Lys Gln Leu Gly Gln  Ile Met Leu 
    2405                 2410                 2415             


Leu Ile  Leu Cys Thr Ser Gln  Ile Leu Leu Met Arg  Thr Thr Trp 
    2420                 2425                 2430             


Ala Leu  Cys Glu Ser Ile Thr  Leu Ala Thr Gly Pro  Leu Thr Thr 
    2435                 2440                 2445             


Leu Trp  Glu Gly Ser Pro Gly  Lys Phe Trp Asn Thr  Thr Ile Ala 
    2450                 2455                 2460             


Val Ser  Met Ala Asn Ile Phe  Arg Gly Ser Tyr Leu  Ala Gly Ala 
    2465                 2470                 2475             


Gly Leu  Ala Phe Ser Leu Met  Lys Ser Leu Gly Gly  Gly Arg Arg 
    2480                 2485                 2490             


Gly Thr  Gly Ala Gln Gly Glu  Thr Leu Gly Glu Lys  Trp Lys Arg 
    2495                 2500                 2505             


Gln Leu  Asn Gln Leu Ser Lys  Ser Glu Phe Asn Thr  Tyr Lys Arg 
    2510                 2515                 2520             


Ser Gly  Ile Met Glu Val Asp  Arg Ser Glu Ala Lys  Glu Gly Leu 
    2525                 2530                 2535             


Lys Arg  Gly Glu Thr Thr Lys  His Ala Val Ser Arg  Gly Thr Ala 
    2540                 2545                 2550             


Lys Leu  Arg Trp Phe Val Glu  Arg Asn Leu Val Lys  Pro Glu Gly 
    2555                 2560                 2565             


Lys Val  Ile Asp Leu Gly Cys  Gly Arg Gly Gly Trp  Ser Tyr Tyr 
    2570                 2575                 2580             


Cys Ala  Gly Leu Lys Lys Val  Thr Glu Val Lys Gly  Tyr Thr Lys 
    2585                 2590                 2595             


Gly Gly  Pro Gly His Glu Glu  Pro Ile Pro Met Ala  Thr Tyr Gly 
    2600                 2605                 2610             


Trp Asn  Leu Val Lys Leu Tyr  Ser Gly Lys Asp Val  Phe Phe Thr 
    2615                 2620                 2625             


Pro Pro  Glu Lys Cys Asp Thr  Leu Leu Cys Asp Ile  Gly Glu Ser 
    2630                 2635                 2640             


Ser Pro  Asn Pro Thr Ile Glu  Glu Gly Arg Thr Leu  Arg Val Leu 
    2645                 2650                 2655             


Lys Met  Val Glu Pro Trp Leu  Arg Gly Asn Gln Phe  Cys Ile Lys 
    2660                 2665                 2670             


Ile Leu  Asn Pro Tyr Met Pro  Ser Val Val Glu Thr  Leu Glu Gln 
    2675                 2680                 2685             


Met Gln  Arg Lys His Gly Gly  Met Leu Val Arg Asn  Pro Leu Ser 
    2690                 2695                 2700             


Arg Asn  Ser Thr His Glu Met  Tyr Trp Val Ser Cys  Gly Thr Gly 
    2705                 2710                 2715             


Asn Ile  Val Ser Ala Val Asn  Met Thr Ser Arg Met  Leu Leu Asn 
    2720                 2725                 2730             


Arg Phe  Thr Met Thr His Arg  Lys Pro Thr Tyr Glu  Arg Asp Val 
    2735                 2740                 2745             


Asp Leu  Gly Ala Gly Thr Arg  His Val Ala Val Glu  Pro Glu Val 
    2750                 2755                 2760             


Ala Asn  Leu Asp Ile Ile Gly  Gln Arg Ile Glu Asn  Ile Lys Asn 
    2765                 2770                 2775             


Glu His  Lys Ser Thr Trp Tyr  Tyr Asp Glu Asp Asn  Pro Tyr Lys 
    2780                 2785                 2790             


Thr Trp  Ala Tyr His Gly Ser  Tyr Glu Val Lys Pro  Ser Gly Ser 
    2795                 2800                 2805             


Ala Ser  Ser Met Val Asn Gly  Val Val Arg Leu Leu  Thr Lys Pro 
    2810                 2815                 2820             


Trp Asp  Val Ile Pro Met Val  Thr Gln Ile Ala Met  Thr Asp Thr 
    2825                 2830                 2835             


Thr Pro  Phe Gly Gln Gln Arg  Val Phe Lys Glu Lys  Val Asp Thr 
    2840                 2845                 2850             


Arg Thr  Pro Arg Ala Lys Arg  Gly Thr Ala Gln Ile  Met Glu Val 
    2855                 2860                 2865             


Thr Ala  Lys Trp Leu Trp Gly  Phe Leu Ser Arg Asn  Lys Lys Pro 
    2870                 2875                 2880             


Arg Ile  Cys Thr Arg Glu Glu  Phe Thr Arg Lys Val  Arg Ser Asn 
    2885                 2890                 2895             


Ala Ala  Ile Gly Ala Val Phe  Val Asp Glu Asn Gln  Trp Asn Ser 
    2900                 2905                 2910             


Ala Lys  Glu Ala Val Glu Asp  Glu Arg Phe Trp Asp  Leu Val His 
    2915                 2920                 2925             


Arg Glu  Arg Glu Leu His Lys  Gln Gly Lys Cys Ala  Thr Cys Val 
    2930                 2935                 2940             


Tyr Asn  Met Met Gly Lys Arg  Glu Lys Lys Leu Gly  Glu Phe Gly 
    2945                 2950                 2955             


Lys Ala  Lys Gly Ser Arg Ala  Ile Trp Tyr Met Trp  Leu Gly Ala 
    2960                 2965                 2970             


Arg Phe  Leu Glu Phe Glu Ala  Leu Gly Phe Met Asn  Glu Asp His 
    2975                 2980                 2985             


Trp Phe  Ser Arg Glu Asn Ser  Phe Ser Gly Val Glu  Gly Glu Gly 
    2990                 2995                 3000             


Leu His  Lys Leu Gly Tyr Ile  Leu Arg Asp Ile Ser  Lys Ile Pro 
    3005                 3010                 3015             


Gly Gly  Asn Met Tyr Ala Asp  Asp Thr Ala Gly Trp  Asp Thr Arg 
    3020                 3025                 3030             


Ile Thr  Glu Asp Asp Leu Gln  Asn Glu Ala Lys Ile  Thr Asp Ile 
    3035                 3040                 3045             


Met Glu  Pro Glu His Ala Leu  Leu Ala Thr Ser Ile  Phe Lys Leu 
    3050                 3055                 3060             


Thr Tyr  Gln Asn Lys Val Val  Arg Val Gln Arg Pro  Ala Lys Asn 
    3065                 3070                 3075             


Gly Thr  Val Met Asp Val Ile  Ser Arg Arg Asp Gln  Arg Gly Ser 
    3080                 3085                 3090             


Gly Gln  Val Gly Thr Tyr Gly  Leu Asn Thr Phe Thr  Asn Met Glu 
    3095                 3100                 3105             


Val Gln  Leu Ile Arg Gln Met  Glu Ser Glu Gly Ile  Phe Leu Pro 
    3110                 3115                 3120             


Ser Glu  Leu Glu Thr Pro Asn  Leu Ala Glu Arg Val  Leu Asn Trp 
    3125                 3130                 3135             


Leu Glu  Lys His Gly Thr Glu  Arg Leu Lys Arg Met  Ala Ile Ser 
    3140                 3145                 3150             


Gly Asp  Asp Cys Val Val Lys  Pro Val Asp Asp Arg  Phe Ala Thr 
    3155                 3160                 3165             


Ala Leu  Ile Ala Leu Asn Asp  Met Gly Lys Val Arg  Lys Asp Ile 
    3170                 3175                 3180             


Pro Gln  Trp Glu Pro Ser Lys  Gly Trp Asn Asp Trp  Gln Gln Val 
    3185                 3190                 3195             


Pro Phe  Cys Ser His His Phe  His Gln Leu Ile Met  Lys Asp Gly 
    3200                 3205                 3210             


Arg Glu  Ile Val Val Pro Cys  Arg Asn Gln Asp Glu  Leu Val Gly 
    3215                 3220                 3225             


Arg Ala  Arg Val Ser Gln Gly  Ala Gly Trp Ser Leu  Arg Glu Thr 
    3230                 3235                 3240             


Ala Cys  Leu Gly Lys Ser Tyr  Ala Gln Met Trp Gln  Leu Met Tyr 
    3245                 3250                 3255             


Phe His  Arg Arg Asp Leu Arg  Leu Ala Ala Asn Ala  Ile Cys Ser 
    3260                 3265                 3270             


Ala Val  Pro Val Asp Trp Val  Pro Thr Ser Arg Thr  Thr Trp Ser 
    3275                 3280                 3285             


Ile His  Ala His His Gln Trp  Met Thr Thr Glu Asp  Met Leu Ser 
    3290                 3295                 3300             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Pro Trp  Met Glu Asp 
    3305                 3310                 3315             


Lys Thr  His Val Ser Ser Trp  Glu Glu Val Pro Tyr  Leu Gly Lys 
    3320                 3325                 3330             


Arg Glu  Asp Gln Trp Cys Gly  Ser Leu Ile Gly Leu  Thr Ala Arg 
    3335                 3340                 3345             


Ala Thr  Trp Ala Thr Asn Ile  Gln Val Ala Ile Asn  Gln Val Arg 
    3350                 3355                 3360             


Arg Leu  Ile Gly Asn Glu Asn  Tyr Leu Asp Tyr Met  Thr Ser Met 
    3365                 3370                 3375             


Lys Arg  Phe Lys Asn Glu Ser  Asp Pro Glu Gly Ala  Leu Trp 
    3380                 3385                 3390         


<210>  2
<211>  3391
<212>  PRT
<213>  Dengue virus serotype 2

<400>  2

Met Asn Asn Gln Arg Lys Lys Ala Lys Asn Thr Pro Phe Asn Met Leu 
1               5                   10                  15      


Lys Arg Glu Arg Asn Arg Val Ser Thr Val Gln Gln Leu Thr Lys Arg 
            20                  25                  30          


Phe Ser Leu Gly Met Leu Gln Gly Arg Gly Pro Leu Lys Leu Phe Met 
        35                  40                  45              


Ala Leu Val Ala Phe Leu Arg Phe Leu Thr Ile Pro Pro Thr Ala Gly 
    50                  55                  60                  


Ile Leu Lys Arg Trp Gly Thr Ile Lys Lys Ser Lys Ala Ile Asn Val 
65                  70                  75                  80  


Leu Arg Gly Phe Arg Lys Glu Ile Gly Arg Met Leu Asn Ile Leu Asn 
                85                  90                  95      


Arg Arg Arg Arg Ser Ala Gly Met Ile Ile Met Leu Ile Pro Thr Val 
            100                 105                 110         


Met Ala Phe His Leu Thr Thr Arg Asn Gly Glu Pro His Met Ile Val 
        115                 120                 125             


Ser Arg Gln Glu Lys Gly Lys Ser Leu Leu Phe Lys Thr Glu Asp Gly 
    130                 135                 140                 


Val Asn Met Cys Thr Leu Met Ala Met Asp Leu Gly Glu Leu Cys Glu 
145                 150                 155                 160 


Asp Thr Ile Thr Tyr Lys Cys Pro Leu Leu Arg Gln Asn Glu Pro Glu 
                165                 170                 175     


Asp Ile Asp Cys Trp Cys Asn Ser Thr Ser Thr Trp Val Thr Tyr Gly 
            180                 185                 190         


Thr Cys Thr Thr Met Gly Glu His Arg Arg Glu Lys Arg Ser Val Ala 
        195                 200                 205             


Leu Val Pro His Val Gly Met Gly Leu Glu Thr Arg Thr Glu Thr Trp 
    210                 215                 220                 


Met Ser Ser Glu Gly Ala Trp Lys His Val Gln Arg Ile Glu Thr Trp 
225                 230                 235                 240 


Ile Leu Arg His Pro Gly Phe Thr Met Met Ala Ala Ile Leu Ala Tyr 
                245                 250                 255     


Thr Ile Gly Thr Thr His Phe Gln Arg Ala Leu Ile Phe Ile Leu Leu 
            260                 265                 270         


Thr Ala Val Thr Pro Ser Met Thr Met Arg Cys Ile Gly Met Ser Asn 
        275                 280                 285             


Arg Asp Phe Val Glu Gly Val Ser Gly Gly Ser Trp Val Asp Ile Val 
    290                 295                 300                 


Leu Glu His Gly Ser Cys Val Thr Thr Met Ala Lys Asn Lys Pro Thr 
305                 310                 315                 320 


Leu Asp Phe Glu Leu Ile Lys Thr Glu Ala Lys Gln Pro Ala Thr Leu 
                325                 330                 335     


Arg Lys Tyr Cys Ile Glu Ala Lys Leu Thr Asn Thr Thr Thr Glu Ser 
            340                 345                 350         


Arg Cys Pro Thr Gln Gly Glu Pro Ser Leu Asn Glu Glu Gln Asp Lys 
        355                 360                 365             


Arg Phe Val Cys Lys His Ser Met Val Asp Arg Gly Trp Gly Asn Gly 
    370                 375                 380                 


Cys Gly Leu Phe Gly Lys Gly Gly Ile Val Thr Cys Ala Met Phe Arg 
385                 390                 395                 400 


Cys Lys Lys Asn Met Glu Gly Lys Val Val Gln Pro Glu Asn Leu Glu 
                405                 410                 415     


Tyr Thr Ile Val Ile Thr Pro His Ser Gly Glu Glu His Ala Val Gly 
            420                 425                 430         


Asn Asp Thr Gly Lys His Gly Lys Glu Ile Lys Ile Thr Pro Gln Ser 
        435                 440                 445             


Ser Ile Thr Glu Ala Glu Leu Thr Gly Tyr Gly Thr Val Thr Met Glu 
    450                 455                 460                 


Cys Ser Pro Arg Thr Gly Leu Asp Phe Asn Glu Met Val Leu Leu Gln 
465                 470                 475                 480 


Met Glu Asn Lys Ala Trp Leu Val His Arg Gln Trp Phe Leu Asp Leu 
                485                 490                 495     


Pro Leu Pro Trp Leu Pro Gly Ala Asp Thr Gln Gly Ser Asn Trp Ile 
            500                 505                 510         


Gln Lys Glu Thr Leu Val Thr Phe Lys Asn Pro His Ala Lys Lys Gln 
        515                 520                 525             


Asp Val Val Val Leu Gly Ser Gln Glu Gly Ala Met His Thr Ala Leu 
    530                 535                 540                 


Thr Gly Ala Thr Glu Ile Gln Met Ser Ser Gly Asn Leu Leu Phe Thr 
545                 550                 555                 560 


Gly His Leu Lys Cys Arg Leu Arg Met Asp Lys Leu Gln Leu Lys Gly 
                565                 570                 575     


Met Ser Tyr Ser Met Cys Thr Gly Lys Phe Lys Val Val Lys Glu Ile 
            580                 585                 590         


Ala Glu Thr Gln His Gly Thr Ile Val Ile Arg Val Gln Tyr Glu Gly 
        595                 600                 605             


Asp Gly Ser Pro Cys Lys Ile Pro Phe Glu Ile Met Asp Leu Glu Lys 
    610                 615                 620                 


Arg His Val Leu Gly Arg Leu Ile Thr Val Asn Pro Ile Val Thr Glu 
625                 630                 635                 640 


Lys Asp Ser Pro Val Asn Ile Glu Ala Glu Pro Pro Phe Gly Asp Ser 
                645                 650                 655     


Tyr Ile Ile Ile Gly Val Glu Pro Gly Gln Leu Lys Leu Asn Trp Phe 
            660                 665                 670         


Lys Lys Gly Ser Ser Ile Gly Gln Met Phe Glu Thr Thr Met Arg Gly 
        675                 680                 685             


Ala Lys Arg Met Ala Ile Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser 
    690                 695                 700                 


Leu Gly Gly Val Phe Thr Ser Ile Gly Lys Ala Leu His Gln Val Phe 
705                 710                 715                 720 


Gly Ala Ile Tyr Gly Ala Ala Phe Ser Gly Val Ser Trp Thr Met Lys 
                725                 730                 735     


Ile Leu Ile Gly Val Ile Ile Thr Trp Ile Gly Met Asn Ser Arg Ser 
            740                 745                 750         


Thr Ser Leu Ser Val Thr Leu Val Leu Val Gly Ile Val Thr Leu Tyr 
        755                 760                 765             


Leu Gly Val Met Val Gln Ala Asp Ser Gly Cys Val Val Ser Trp Lys 
    770                 775                 780                 


Asn Lys Glu Leu Lys Cys Gly Ser Gly Ile Phe Ile Thr Asp Asn Val 
785                 790                 795                 800 


His Thr Trp Thr Glu Gln Tyr Lys Phe Gln Pro Glu Ser Pro Ser Lys 
                805                 810                 815     


Leu Ala Ser Ala Ile Gln Lys Ala His Glu Glu Gly Ile Cys Gly Ile 
            820                 825                 830         


Arg Ser Val Thr Arg Leu Glu Asn Leu Met Trp Lys Gln Ile Thr Pro 
        835                 840                 845             


Glu Leu Asn His Ile Leu Ser Glu Asn Glu Val Lys Leu Thr Ile Met 
    850                 855                 860                 


Thr Gly Asp Ile Lys Gly Ile Met Gln Ala Gly Lys Arg Ser Leu Arg 
865                 870                 875                 880 


Pro Gln Pro Thr Glu Leu Lys Tyr Ser Trp Lys Thr Trp Gly Lys Ala 
                885                 890                 895     


Lys Met Leu Ser Thr Glu Ser His Asn Gln Thr Phe Leu Ile Asp Gly 
            900                 905                 910         


Pro Glu Thr Ala Glu Cys Pro Asn Thr Asn Arg Ala Trp Asn Ser Leu 
        915                 920                 925             


Glu Val Glu Asp Tyr Gly Phe Gly Val Phe Thr Thr Asn Ile Trp Leu 
    930                 935                 940                 


Lys Leu Lys Glu Lys Gln Asp Val Phe Cys Asp Ser Lys Leu Met Ser 
945                 950                 955                 960 


Ala Ala Ile Lys Asp Asn Arg Ala Val His Ala Asp Met Gly Tyr Trp 
                965                 970                 975     


Ile Glu Ser Ala Leu Asn Asp Thr Trp Lys Ile Glu Lys Ala Ser Phe 
            980                 985                 990         


Ile Glu Val Lys Asn Cys His Trp  Pro Lys Ser His Thr  Leu Trp Ser 
        995                 1000                 1005             


Asn Gly  Val Leu Glu Ser Glu  Met Ile Ile Pro Lys  Asn Leu Ala 
    1010                 1015                 1020             


Gly Pro  Val Ser Gln His Asn  Tyr Arg Pro Gly Tyr  His Thr Gln 
    1025                 1030                 1035             


Ile Thr  Gly Pro Trp His Leu  Gly Lys Leu Glu Met  Asp Phe Asp 
    1040                 1045                 1050             


Phe Cys  Asp Gly Thr Thr Val  Val Val Thr Glu Asp  Cys Gly Asn 
    1055                 1060                 1065             


Arg Gly  Pro Ser Leu Arg Thr  Thr Thr Ala Ser Gly  Lys Leu Ile 
    1070                 1075                 1080             


Thr Glu  Trp Cys Cys Arg Ser  Cys Thr Leu Pro Pro  Leu Arg Tyr 
    1085                 1090                 1095             


Arg Gly  Glu Asp Gly Cys Trp  Tyr Gly Met Glu Ile  Arg Pro Leu 
    1100                 1105                 1110             


Lys Glu  Lys Glu Glu Asn Leu  Val Asn Ser Leu Val  Thr Ala Gly 
    1115                 1120                 1125             


His Gly  Gln Val Asp Asn Phe  Ser Leu Gly Val Leu  Gly Met Ala 
    1130                 1135                 1140             


Leu Phe  Leu Glu Glu Met Leu  Arg Thr Arg Val Gly  Thr Lys His 
    1145                 1150                 1155             


Ala Ile  Leu Leu Val Ala Val  Ser Phe Val Thr Leu  Ile Thr Gly 
    1160                 1165                 1170             


Asn Met  Ser Phe Arg Asp Leu  Gly Arg Val Met Val  Met Val Gly 
    1175                 1180                 1185             


Ala Thr  Met Thr Asp Asp Ile  Gly Met Gly Val Thr  Tyr Leu Ala 
    1190                 1195                 1200             


Leu Leu  Ala Ala Phe Lys Val  Arg Pro Thr Phe Ala  Ala Gly Leu 
    1205                 1210                 1215             


Leu Leu  Arg Lys Leu Thr Ser  Lys Glu Leu Met Met  Thr Thr Ile 
    1220                 1225                 1230             


Gly Ile  Val Leu Leu Ser Gln  Ser Thr Ile Pro Glu  Thr Ile Leu 
    1235                 1240                 1245             


Glu Leu  Thr Asp Ala Leu Ala  Leu Gly Met Met Val  Leu Lys Met 
    1250                 1255                 1260             


Val Arg  Asn Met Glu Lys Tyr  Gln Leu Ala Val Thr  Ile Met Ala 
    1265                 1270                 1275             


Ile Leu  Cys Val Pro Asn Ala  Val Ile Leu Gln Asn  Ala Trp Lys 
    1280                 1285                 1290             


Val Ser  Cys Thr Ile Leu Ala  Val Val Ser Val Ser  Pro Leu Leu 
    1295                 1300                 1305             


Leu Thr  Ser Ser Gln Gln Lys  Thr Asp Trp Ile Pro  Leu Ala Leu 
    1310                 1315                 1320             


Thr Ile  Lys Gly Leu Asn Pro  Thr Ala Ile Phe Leu  Thr Thr Leu 
    1325                 1330                 1335             


Ser Arg  Thr Ser Lys Lys Arg  Ser Trp Pro Leu Asn  Glu Ala Ile 
    1340                 1345                 1350             


Met Ala  Val Gly Met Val Ser  Ile Leu Ala Ser Ser  Leu Leu Lys 
    1355                 1360                 1365             


Asn Asp  Ile Pro Met Thr Gly  Pro Leu Val Ala Gly  Gly Leu Leu 
    1370                 1375                 1380             


Thr Val  Cys Tyr Val Leu Thr  Gly Arg Ser Ala Asp  Leu Glu Leu 
    1385                 1390                 1395             


Glu Arg  Ala Ala Asp Val Lys  Trp Glu Asp Gln Ala  Glu Ile Ser 
    1400                 1405                 1410             


Gly Ser  Ser Pro Ile Leu Ser  Ile Thr Ile Ser Glu  Asp Gly Ser 
    1415                 1420                 1425             


Met Ser  Ile Lys Asn Glu Glu  Glu Glu Gln Thr Leu  Thr Ile Leu 
    1430                 1435                 1440             


Ile Arg  Thr Gly Leu Leu Val  Ile Ser Gly Leu Phe  Pro Val Ser 
    1445                 1450                 1455             


Ile Pro  Ile Thr Ala Ala Ala  Trp Tyr Leu Trp Glu  Val Lys Lys 
    1460                 1465                 1470             


Gln Arg  Ala Gly Val Leu Trp  Asp Val Pro Ser Pro  Pro Pro Met 
    1475                 1480                 1485             


Gly Lys  Ala Glu Leu Glu Asp  Gly Ala Tyr Arg Ile  Lys Gln Lys 
    1490                 1495                 1500             


Gly Ile  Leu Gly Tyr Ser Gln  Ile Gly Ala Gly Val  Tyr Lys Glu 
    1505                 1510                 1515             


Gly Thr  Phe His Thr Met Trp  His Val Thr Arg Gly  Ala Val Leu 
    1520                 1525                 1530             


Met His  Lys Gly Lys Arg Ile  Glu Pro Ser Trp Ala  Asp Val Lys 
    1535                 1540                 1545             


Lys Asp  Leu Ile Ser Tyr Gly  Gly Gly Trp Lys Leu  Glu Gly Glu 
    1550                 1555                 1560             


Trp Lys  Glu Gly Glu Glu Val  Gln Val Leu Ala Leu  Glu Pro Gly 
    1565                 1570                 1575             


Lys Asn  Pro Arg Ala Val Gln  Thr Lys Pro Gly Leu  Phe Lys Thr 
    1580                 1585                 1590             


Asn Ala  Gly Thr Ile Gly Ala  Val Ser Leu Asp Phe  Ser Pro Gly 
    1595                 1600                 1605             


Thr Ser  Gly Ser Pro Ile Ile  Asp Lys Lys Gly Lys  Val Val Gly 
    1610                 1615                 1620             


Leu Tyr  Gly Asn Gly Val Val  Thr Arg Ser Gly Ala  Tyr Val Ser 
    1625                 1630                 1635             


Ala Ile  Ala Gln Thr Glu Lys  Ser Ile Glu Asp Asn  Pro Glu Ile 
    1640                 1645                 1650             


Glu Asp  Asp Ile Phe Arg Lys  Arg Arg Leu Thr Ile  Met Asp Leu 
    1655                 1660                 1665             


His Pro  Gly Ala Gly Lys Thr  Lys Arg Tyr Leu Pro  Ala Ile Val 
    1670                 1675                 1680             


Arg Glu  Ala Ile Lys Arg Gly  Leu Arg Thr Leu Ile  Leu Ala Pro 
    1685                 1690                 1695             


Thr Arg  Val Val Ala Ala Glu  Met Glu Glu Ala Leu  Arg Gly Leu 
    1700                 1705                 1710             


Pro Ile  Arg Tyr Gln Thr Pro  Ala Ile Arg Ala Glu  His Thr Gly 
    1715                 1720                 1725             


Arg Glu  Ile Val Asp Leu Met  Cys His Ala Thr Phe  Thr Met Arg 
    1730                 1735                 1740             


Leu Leu  Ser Pro Val Arg Val  Pro Asn Tyr Asn Leu  Ile Ile Met 
    1745                 1750                 1755             


Asp Glu  Ala His Phe Thr Asp  Pro Ala Ser Ile Ala  Ala Arg Gly 
    1760                 1765                 1770             


Tyr Ile  Ser Thr Arg Val Glu  Met Gly Glu Ala Ala  Gly Ile Phe 
    1775                 1780                 1785             


Met Thr  Ala Thr Pro Pro Gly  Ser Arg Asp Pro Phe  Pro Gln Ser 
    1790                 1795                 1800             


Asn Ala  Pro Ile Ile Asp Glu  Glu Arg Glu Ile Pro  Glu Arg Ser 
    1805                 1810                 1815             


Trp Asn  Ser Gly His Glu Trp  Val Thr Asp Phe Lys  Gly Lys Thr 
    1820                 1825                 1830             


Val Trp  Phe Val Pro Ser Ile  Lys Ala Gly Asn Asp  Ile Ala Ala 
    1835                 1840                 1845             


Cys Leu  Arg Lys Asn Gly Lys  Lys Val Ile Gln Leu  Ser Arg Lys 
    1850                 1855                 1860             


Thr Phe  Asp Ser Glu Tyr Val  Lys Thr Arg Thr Asn  Asp Trp Asp 
    1865                 1870                 1875             


Phe Val  Val Thr Thr Asp Ile  Ser Glu Met Gly Ala  Asn Phe Lys 
    1880                 1885                 1890             


Ala Glu  Arg Val Ile Asp Pro  Arg Arg Cys Met Lys  Pro Val Ile 
    1895                 1900                 1905             


Leu Thr  Asp Gly Glu Glu Arg  Val Ile Leu Ala Gly  Pro Met Pro 
    1910                 1915                 1920             


Val Thr  His Ser Ser Ala Ala  Gln Arg Arg Gly Arg  Ile Gly Arg 
    1925                 1930                 1935             


Asn Pro  Lys Asn Glu Asn Asp  Gln Tyr Ile Tyr Met  Gly Glu Pro 
    1940                 1945                 1950             


Leu Glu  Asn Asp Glu Asp Cys  Ala His Trp Lys Glu  Ala Lys Met 
    1955                 1960                 1965             


Leu Leu  Asp Asn Ile Asn Thr  Pro Glu Gly Ile Ile  Pro Ser Met 
    1970                 1975                 1980             


Phe Glu  Pro Glu Arg Glu Lys  Val Asp Ala Ile Asp  Gly Glu Tyr 
    1985                 1990                 1995             


Arg Leu  Arg Gly Glu Ala Arg  Lys Thr Phe Val Asp  Leu Met Arg 
    2000                 2005                 2010             


Arg Gly  Asp Leu Pro Val Trp  Leu Ala Tyr Arg Val  Ala Ala Glu 
    2015                 2020                 2025             


Gly Ile  Asn Tyr Ala Asp Arg  Arg Trp Cys Phe Asp  Gly Val Lys 
    2030                 2035                 2040             


Asn Asn  Gln Ile Leu Glu Glu  Asn Val Glu Val Glu  Ile Trp Thr 
    2045                 2050                 2055             


Lys Glu  Gly Glu Arg Lys Lys  Leu Lys Pro Arg Trp  Leu Asp Ala 
    2060                 2065                 2070             


Arg Ile  Tyr Ser Asp Pro Leu  Ala Leu Lys Glu Phe  Lys Glu Phe 
    2075                 2080                 2085             


Ala Ala  Gly Arg Lys Ser Leu  Thr Leu Asn Leu Ile  Thr Glu Met 
    2090                 2095                 2100             


Gly Arg  Leu Pro Thr Phe Met  Thr Gln Lys Ala Arg  Asp Ala Leu 
    2105                 2110                 2115             


Asp Asn  Leu Ala Val Leu His  Thr Ala Glu Ala Gly  Gly Arg Ala 
    2120                 2125                 2130             


Tyr Asn  His Ala Leu Ser Glu  Leu Pro Glu Thr Leu  Glu Thr Leu 
    2135                 2140                 2145             


Leu Leu  Leu Thr Leu Leu Ala  Thr Val Thr Gly Gly  Ile Phe Leu 
    2150                 2155                 2160             


Phe Leu  Met Ser Gly Arg Gly  Ile Gly Lys Met Thr  Leu Gly Met 
    2165                 2170                 2175             


Cys Cys  Ile Ile Thr Ala Ser  Ile Leu Leu Trp Tyr  Ala Gln Ile 
    2180                 2185                 2190             


Gln Pro  His Trp Ile Ala Ala  Ser Ile Ile Leu Glu  Phe Phe Leu 
    2195                 2200                 2205             


Ile Val  Leu Leu Ile Pro Glu  Pro Glu Lys Gln Arg  Thr Pro Gln 
    2210                 2215                 2220             


Asp Asn  Gln Leu Thr Tyr Val  Val Ile Ala Ile Leu  Thr Val Val 
    2225                 2230                 2235             


Ala Ala  Thr Met Ala Asn Glu  Met Gly Phe Leu Glu  Lys Thr Lys 
    2240                 2245                 2250             


Lys Asp  Leu Gly Leu Gly Ser  Ile Ala Thr Gln Gln  Pro Glu Ser 
    2255                 2260                 2265             


Asn Ile  Leu Asp Ile Asp Leu  Arg Pro Ala Ser Ala  Trp Thr Leu 
    2270                 2275                 2280             


Tyr Ala  Val Ala Thr Thr Phe  Val Thr Pro Met Leu  Arg His Ser 
    2285                 2290                 2295             


Ile Glu  Asn Ser Ser Val Asn  Val Ser Leu Thr Ala  Ile Ala Asn 
    2300                 2305                 2310             


Gln Ala  Thr Val Leu Met Gly  Leu Gly Lys Gly Trp  Pro Leu Ser 
    2315                 2320                 2325             


Lys Met  Asp Ile Gly Val Pro  Leu Leu Ala Ile Gly  Cys Tyr Ser 
    2330                 2335                 2340             


Gln Val  Asn Pro Ile Thr Leu  Thr Ala Ala Leu Phe  Leu Leu Val 
    2345                 2350                 2355             


Ala His  Tyr Ala Ile Ile Gly  Pro Gly Leu Gln Ala  Lys Ala Thr 
    2360                 2365                 2370             


Arg Glu  Ala Gln Lys Arg Ala  Ala Ala Gly Ile Met  Lys Asn Pro 
    2375                 2380                 2385             


Thr Val  Asp Gly Ile Thr Val  Ile Asp Leu Asp Pro  Ile Pro Tyr 
    2390                 2395                 2400             


Asp Pro  Lys Phe Glu Lys Gln  Leu Gly Gln Val Met  Leu Leu Val 
    2405                 2410                 2415             


Leu Cys  Val Thr Gln Val Leu  Met Met Arg Thr Thr  Trp Ala Leu 
    2420                 2425                 2430             


Cys Glu  Ala Leu Thr Leu Ala  Thr Gly Pro Ile Ser  Thr Leu Trp 
    2435                 2440                 2445             


Glu Gly  Asn Pro Gly Arg Phe  Trp Asn Thr Thr Ile  Ala Val Ser 
    2450                 2455                 2460             


Met Ala  Asn Ile Phe Arg Gly  Ser Tyr Leu Ala Gly  Ala Gly Leu 
    2465                 2470                 2475             


Leu Phe  Ser Ile Met Lys Asn  Thr Thr Asn Thr Arg  Arg Gly Thr 
    2480                 2485                 2490             


Gly Asn  Ile Gly Glu Thr Leu  Gly Glu Lys Trp Lys  Ser Arg Leu 
    2495                 2500                 2505             


Asn Ala  Leu Gly Lys Ser Glu  Phe Gln Ile Tyr Lys  Lys Ser Gly 
    2510                 2515                 2520             


Ile Gln  Glu Val Asp Arg Thr  Leu Ala Lys Glu Gly  Ile Lys Arg 
    2525                 2530                 2535             


Gly Glu  Thr Asp His His Ala  Val Ser Arg Gly Ser  Ala Lys Leu 
    2540                 2545                 2550             


Arg Trp  Phe Val Glu Arg Asn  Met Val Thr Pro Glu  Gly Lys Val 
    2555                 2560                 2565             


Val Asp  Leu Gly Cys Gly Arg  Gly Gly Trp Ser Tyr  Tyr Cys Gly 
    2570                 2575                 2580             


Gly Leu  Lys Asn Val Arg Glu  Val Lys Gly Leu Thr  Lys Gly Gly 
    2585                 2590                 2595             


Pro Gly  His Glu Glu Pro Ile  Pro Met Ser Thr Tyr  Gly Trp Asn 
    2600                 2605                 2610             


Leu Val  Arg Leu Gln Ser Gly  Val Asp Val Phe Phe  Ile Pro Pro 
    2615                 2620                 2625             


Glu Lys  Cys Asp Thr Leu Leu  Cys Asp Ile Gly Glu  Ser Ser Pro 
    2630                 2635                 2640             


Asn Pro  Thr Val Glu Ala Gly  Arg Thr Leu Arg Val  Leu Asn Leu 
    2645                 2650                 2655             


Val Glu  Asn Trp Leu Asn Asn  Asn Thr Gln Phe Cys  Ile Lys Val 
    2660                 2665                 2670             


Leu Asn  Pro Tyr Met Pro Ser  Val Ile Glu Lys Met  Glu Ala Leu 
    2675                 2680                 2685             


Gln Arg  Lys Tyr Gly Gly Ala  Leu Val Arg Asn Pro  Leu Ser Arg 
    2690                 2695                 2700             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Asn Ala  Ser Gly Asn 
    2705                 2710                 2715             


Ile Val  Ser Ser Val Asn Met  Ile Ser Arg Met Leu  Ile Asn Arg 
    2720                 2725                 2730             


Phe Thr  Met Arg Tyr Lys Lys  Ala Thr Tyr Glu Pro  Asp Val Asp 
    2735                 2740                 2745             


Leu Gly  Ser Gly Thr Arg Asn  Ile Gly Ile Glu Ser  Glu Ile Pro 
    2750                 2755                 2760             


Asn Leu  Asp Ile Ile Gly Lys  Arg Ile Glu Lys Ile  Lys Gln Glu 
    2765                 2770                 2775             


His Glu  Thr Ser Trp His Tyr  Asp Gln Asp His Pro  Tyr Lys Thr 
    2780                 2785                 2790             


Trp Ala  Tyr His Gly Ser Tyr  Glu Thr Lys Gln Thr  Gly Ser Ala 
    2795                 2800                 2805             


Ser Ser  Met Val Asn Gly Val  Val Arg Leu Leu Thr  Lys Pro Trp 
    2810                 2815                 2820             


Asp Val  Val Pro Met Val Thr  Gln Met Ala Met Thr  Asp Thr Thr 
    2825                 2830                 2835             


Pro Phe  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2840                 2845                 2850             


Thr Gln  Glu Pro Lys Glu Gly  Thr Lys Lys Leu Met  Lys Ile Thr 
    2855                 2860                 2865             


Ala Glu  Trp Leu Trp Lys Glu  Leu Gly Lys Lys Lys  Thr Pro Arg 
    2870                 2875                 2880             


Met Cys  Thr Arg Glu Glu Phe  Thr Arg Lys Val Arg  Ser Asn Ala 
    2885                 2890                 2895             


Ala Leu  Gly Ala Ile Phe Thr  Asp Glu Asn Lys Trp  Lys Ser Ala 
    2900                 2905                 2910             


Arg Glu  Ala Val Glu Asp Ser  Arg Phe Trp Glu Leu  Val Asp Lys 
    2915                 2920                 2925             


Glu Arg  Asn Leu His Leu Glu  Gly Lys Cys Glu Thr  Cys Val Tyr 
    2930                 2935                 2940             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Leu Gly Glu  Phe Gly Lys 
    2945                 2950                 2955             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2960                 2965                 2970             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    2975                 2980                 2985             


Phe Ser  Arg Glu Asn Ser Leu  Ser Gly Val Glu Gly  Glu Gly Leu 
    2990                 2995                 3000             


His Lys  Leu Gly Tyr Ile Leu  Arg Asp Val Ser Lys  Lys Glu Gly 
    3005                 3010                 3015             


Gly Ala  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3020                 3025                 3030             


Thr Leu  Glu Asp Leu Lys Asn  Glu Glu Met Val Thr  Asn His Met 
    3035                 3040                 3045             


Glu Gly  Glu His Lys Lys Leu  Ala Glu Ala Ile Phe  Lys Leu Thr 
    3050                 3055                 3060             


Tyr Gln  Asn Lys Val Val Arg  Val Gln Arg Pro Thr  Pro Arg Gly 
    3065                 3070                 3075             


Thr Val  Met Asp Ile Ile Ser  Arg Arg Asp Gln Arg  Gly Ser Gly 
    3080                 3085                 3090             


Gln Val  Gly Thr Tyr Gly Leu  Asn Thr Phe Thr Asn  Met Glu Ala 
    3095                 3100                 3105             


Gln Leu  Ile Arg Gln Met Glu  Gly Glu Gly Val Phe  Lys Ser Ile 
    3110                 3115                 3120             


Gln His  Leu Thr Ile Thr Glu  Glu Ile Ala Val Gln  Asn Trp Leu 
    3125                 3130                 3135             


Ala Arg  Val Gly Arg Glu Arg  Leu Ser Arg Met Ala  Ile Ser Gly 
    3140                 3145                 3150             


Asp Asp  Cys Val Val Lys Pro  Leu Asp Asp Arg Phe  Ala Ser Ala 
    3155                 3160                 3165             


Leu Thr  Ala Leu Asn Asp Met  Gly Lys Ile Arg Lys  Asp Ile Gln 
    3170                 3175                 3180             


Gln Trp  Glu Pro Ser Arg Gly  Trp Asn Asp Trp Thr  Gln Val Pro 
    3185                 3190                 3195             


Phe Cys  Ser His His Phe His  Glu Leu Ile Met Lys  Asp Gly Arg 
    3200                 3205                 3210             


Val Leu  Val Val Pro Cys Arg  Asn Gln Asp Glu Leu  Ile Gly Arg 
    3215                 3220                 3225             


Ala Arg  Ile Ser Gln Gly Ala  Gly Trp Ser Leu Arg  Glu Thr Ala 
    3230                 3235                 3240             


Cys Leu  Gly Lys Ser Tyr Ala  Gln Met Trp Ser Leu  Met Tyr Phe 
    3245                 3250                 3255             


His Arg  Arg Asp Leu Arg Leu  Ala Ala Asn Ala Ile  Cys Ser Ala 
    3260                 3265                 3270             


Val Pro  Ser His Trp Val Pro  Thr Ser Arg Thr Thr  Trp Ser Ile 
    3275                 3280                 3285             


His Ala  Lys His Glu Trp Met  Thr Thr Glu Asp Met  Leu Thr Val 
    3290                 3295                 3300             


Trp Asn  Arg Val Trp Ile Gln  Glu Asn Pro Trp Met  Glu Asp Lys 
    3305                 3310                 3315             


Thr Pro  Val Glu Ser Trp Glu  Glu Ile Pro Tyr Leu  Gly Lys Arg 
    3320                 3325                 3330             


Glu Asp  Gln Trp Cys Gly Ser  Leu Ile Gly Leu Thr  Ser Arg Ala 
    3335                 3340                 3345             


Thr Trp  Ala Lys Asn Ile Gln  Ala Ala Ile Asn Gln  Val Arg Ser 
    3350                 3355                 3360             


Leu Ile  Gly Asn Glu Glu Tyr  Thr Asp Tyr Met Pro  Ser Met Lys 
    3365                 3370                 3375             


Arg Phe  Arg Arg Glu Glu Glu  Glu Ala Gly Val Leu  Trp 
    3380                 3385                 3390     


<210>  3
<211>  3390
<212>  PRT
<213>  Dengue virus serotype 3

<400>  3

Met Asn Asn Gln Arg Lys Lys Thr Gly Lys Pro Ser Ile Asn Met Leu 
1               5                   10                  15      


Lys Arg Val Arg Asn Arg Val Ser Thr Gly Ser Gln Leu Ala Lys Arg 
            20                  25                  30          


Phe Ser Lys Gly Leu Leu Asn Gly Gln Gly Pro Met Lys Leu Val Met 
        35                  40                  45              


Ala Phe Ile Ala Phe Leu Arg Phe Leu Ala Ile Pro Pro Thr Ala Gly 
    50                  55                  60                  


Val Leu Ala Arg Trp Gly Thr Phe Lys Lys Ser Gly Ala Ile Lys Val 
65                  70                  75                  80  


Leu Lys Gly Phe Lys Lys Glu Ile Ser Asn Met Leu Ser Ile Ile Asn 
                85                  90                  95      


Gln Arg Lys Lys Thr Ser Leu Cys Leu Met Met Ile Leu Pro Ala Ala 
            100                 105                 110         


Leu Ala Phe His Leu Thr Ser Arg Asp Gly Glu Pro Arg Met Ile Val 
        115                 120                 125             


Gly Lys Asn Glu Arg Gly Lys Ser Leu Leu Phe Lys Thr Ala Ser Gly 
    130                 135                 140                 


Ile Asn Met Cys Thr Leu Ile Ala Met Asp Leu Gly Glu Met Cys Asp 
145                 150                 155                 160 


Asp Thr Val Thr Tyr Lys Cys Pro His Ile Thr Glu Val Glu Pro Glu 
                165                 170                 175     


Asp Ile Asp Cys Trp Cys Asn Leu Thr Ser Thr Trp Val Thr Tyr Gly 
            180                 185                 190         


Thr Cys Asn Gln Ala Gly Glu His Arg Arg Asp Lys Arg Ser Val Ala 
        195                 200                 205             


Leu Ala Pro His Val Gly Met Gly Leu Asp Thr Arg Thr Gln Thr Trp 
    210                 215                 220                 


Met Ser Ala Glu Gly Ala Trp Arg Gln Val Glu Lys Val Glu Thr Trp 
225                 230                 235                 240 


Ala Leu Arg His Pro Gly Phe Thr Ile Leu Ala Leu Phe Leu Ala His 
                245                 250                 255     


Tyr Ile Gly Thr Ser Leu Thr Gln Lys Val Val Ile Phe Ile Leu Leu 
            260                 265                 270         


Met Leu Val Thr Pro Ser Met Thr Met Arg Cys Val Gly Val Gly Asn 
        275                 280                 285             


Arg Asp Phe Val Glu Gly Leu Ser Gly Ala Thr Trp Val Asp Val Val 
    290                 295                 300                 


Leu Glu His Gly Gly Cys Val Thr Thr Met Ala Lys Asn Lys Pro Thr 
305                 310                 315                 320 


Leu Asp Ile Glu Leu Gln Lys Thr Glu Ala Thr Gln Leu Ala Thr Leu 
                325                 330                 335     


Arg Lys Leu Cys Ile Glu Gly Lys Ile Thr Asn Ile Thr Thr Asp Ser 
            340                 345                 350         


Arg Cys Pro Thr Gln Gly Glu Ala Val Leu Pro Glu Glu Gln Asp Gln 
        355                 360                 365             


Asn Tyr Val Cys Lys His Thr Tyr Val Asp Arg Gly Trp Gly Asn Gly 
    370                 375                 380                 


Cys Gly Leu Phe Gly Lys Gly Ser Leu Val Thr Cys Ala Lys Phe Gln 
385                 390                 395                 400 


Cys Leu Glu Pro Ile Glu Gly Lys Val Val Gln Tyr Glu Asn Leu Lys 
                405                 410                 415     


Tyr Thr Val Ile Ile Thr Val His Thr Gly Asp Gln His Gln Val Gly 
            420                 425                 430         


Asn Glu Thr Gln Gly Val Thr Ala Glu Ile Thr Pro Gln Ala Ser Thr 
        435                 440                 445             


Thr Glu Ala Ile Leu Pro Glu Tyr Gly Thr Leu Gly Leu Glu Cys Ser 
    450                 455                 460                 


Pro Arg Thr Gly Leu Asp Phe Asn Glu Met Ile Leu Leu Thr Met Lys 
465                 470                 475                 480 


Asn Lys Ala Trp Met Val His Arg Gln Trp Phe Phe Asp Leu Pro Leu 
                485                 490                 495     


Pro Trp Ala Ser Gly Ala Thr Thr Glu Thr Pro Thr Trp Asn Arg Lys 
            500                 505                 510         


Glu Leu Leu Val Thr Phe Lys Asn Ala His Ala Lys Lys Gln Glu Val 
        515                 520                 525             


Val Val Leu Gly Ser Gln Glu Gly Ala Met His Thr Ala Leu Thr Gly 
    530                 535                 540                 


Ala Thr Glu Ile Gln Asn Ser Gly Gly Thr Ser Ile Phe Ala Gly His 
545                 550                 555                 560 


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Glu Leu Lys Gly Met Ser 
                565                 570                 575     


Tyr Ala Met Cys Thr Asn Thr Phe Val Leu Lys Lys Glu Val Ser Glu 
            580                 585                 590         


Thr Gln His Gly Thr Ile Leu Ile Lys Val Glu Tyr Lys Gly Glu Asp 
        595                 600                 605             


Ala Pro Cys Lys Ile Pro Phe Ser Thr Glu Asp Gly Gln Gly Lys Ala 
    610                 615                 620                 


His Asn Gly Arg Leu Ile Thr Ala Asn Pro Val Val Thr Lys Lys Glu 
625                 630                 635                 640 


Glu Pro Val Asn Ile Glu Ala Glu Pro Pro Phe Gly Glu Ser Asn Ile 
                645                 650                 655     


Val Ile Gly Ile Gly Asp Asn Ala Leu Lys Ile Asn Trp Tyr Lys Lys 
            660                 665                 670         


Gly Ser Ser Ile Gly Lys Met Phe Glu Ala Thr Glu Arg Gly Ala Arg 
        675                 680                 685             


Arg Met Ala Ile Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Val Gly 
    690                 695                 700                 


Gly Val Leu Asn Ser Leu Gly Lys Met Val His Gln Ile Phe Gly Ser 
705                 710                 715                 720 


Ala Tyr Thr Ala Leu Phe Ser Gly Val Ser Trp Val Met Lys Ile Gly 
                725                 730                 735     


Ile Gly Val Leu Leu Thr Trp Ile Gly Leu Asn Ser Lys Asn Thr Ser 
            740                 745                 750         


Met Ser Phe Ser Cys Ile Ala Ile Gly Ile Ile Thr Leu Tyr Leu Gly 
        755                 760                 765             


Ala Val Val Gln Ala Asp Met Gly Cys Val Ile Asn Trp Lys Gly Lys 
    770                 775                 780                 


Glu Leu Lys Cys Gly Ser Gly Ile Phe Val Thr Asn Glu Val His Thr 
785                 790                 795                 800 


Trp Thr Glu Gln Tyr Lys Phe Gln Ala Asp Ser Pro Lys Arg Leu Ala 
                805                 810                 815     


Thr Ala Ile Ala Gly Ala Trp Glu Asn Gly Val Cys Gly Ile Arg Ser 
            820                 825                 830         


Thr Thr Arg Met Glu Asn Leu Leu Trp Lys Gln Ile Ala Asn Glu Leu 
        835                 840                 845             


Asn Tyr Ile Leu Trp Glu Asn Asn Ile Lys Leu Thr Val Val Val Gly 
    850                 855                 860                 


Asp Thr Leu Gly Val Leu Glu Gln Gly Lys Arg Thr Leu Thr Pro Gln 
865                 870                 875                 880 


Pro Met Glu Leu Lys Tyr Ser Trp Lys Thr Trp Gly Lys Ala Lys Ile 
                885                 890                 895     


Val Thr Ala Glu Thr Gln Asn Ser Ser Phe Ile Ile Asp Gly Pro Asn 
            900                 905                 910         


Thr Pro Glu Cys Pro Ser Ala Ser Arg Ala Trp Asn Val Trp Glu Val 
        915                 920                 925             


Glu Asp Tyr Gly Phe Gly Val Phe Thr Thr Asn Ile Trp Leu Lys Leu 
    930                 935                 940                 


Arg Glu Val Tyr Thr Gln Leu Cys Asp His Arg Leu Met Ser Ala Ala 
945                 950                 955                 960 


Val Lys Asp Glu Arg Ala Val His Ala Asp Met Gly Tyr Trp Ile Glu 
                965                 970                 975     


Ser Gln Lys Asn Gly Ser Trp Lys Leu Glu Lys Ala Ser Leu Ile Glu 
            980                 985                 990         


Val Lys Thr Cys Thr Trp Pro Lys  Ser His Thr Leu Trp  Thr Asn Gly 
        995                 1000                 1005             


Val Leu  Glu Ser Asp Met Ile  Ile Pro Lys Ser Leu  Ala Gly Pro 
    1010                 1015                 1020             


Ile Ser  Gln His Asn Tyr Arg  Pro Gly Tyr His Thr  Gln Thr Ala 
    1025                 1030                 1035             


Gly Pro  Trp His Leu Gly Lys  Leu Glu Leu Asp Phe  Asn Tyr Cys 
    1040                 1045                 1050             


Glu Gly  Thr Thr Val Val Ile  Thr Glu Ser Cys Gly  Thr Arg Gly 
    1055                 1060                 1065             


Pro Ser  Leu Arg Thr Thr Thr  Val Ser Gly Lys Leu  Ile His Glu 
    1070                 1075                 1080             


Trp Cys  Cys Arg Ser Cys Thr  Leu Pro Pro Leu Arg  Tyr Met Gly 
    1085                 1090                 1095             


Glu Asp  Gly Cys Trp Tyr Gly  Met Glu Ile Arg Pro  Ile Ser Glu 
    1100                 1105                 1110             


Lys Glu  Glu Asn Met Val Lys  Ser Leu Val Ser Ala  Gly Ser Gly 
    1115                 1120                 1125             


Lys Val  Asp Asn Phe Thr Met  Gly Val Leu Cys Leu  Ala Ile Leu 
    1130                 1135                 1140             


Phe Glu  Glu Val Leu Arg Gly  Lys Phe Gly Lys Lys  His Met Ile 
    1145                 1150                 1155             


Ala Gly  Val Phe Phe Thr Phe  Val Leu Leu Leu Ser  Gly Gln Ile 
    1160                 1165                 1170             


Thr Trp  Arg Asp Met Ala His  Thr Leu Ile Met Ile  Gly Ser Asn 
    1175                 1180                 1185             


Ala Ser  Asp Arg Met Gly Met  Gly Val Thr Tyr Leu  Ala Leu Ile 
    1190                 1195                 1200             


Ala Thr  Phe Lys Ile Gln Pro  Phe Leu Ala Leu Gly  Phe Phe Leu 
    1205                 1210                 1215             


Arg Lys  Leu Thr Ser Arg Glu  Asn Leu Leu Leu Gly  Val Gly Leu 
    1220                 1225                 1230             


Ala Met  Ala Thr Thr Leu Gln  Leu Pro Glu Asp Ile  Glu Gln Met 
    1235                 1240                 1245             


Ala Asn  Gly Val Ala Leu Gly  Leu Met Ala Leu Lys  Leu Ile Thr 
    1250                 1255                 1260             


Gln Phe  Glu Thr Tyr Gln Leu  Trp Thr Ala Leu Val  Ser Leu Thr 
    1265                 1270                 1275             


Cys Ser  Asn Thr Ile Phe Thr  Leu Thr Val Ala Trp  Arg Thr Ala 
    1280                 1285                 1290             


Thr Leu  Ile Leu Ala Gly Val  Ser Leu Leu Pro Val  Cys Gln Ser 
    1295                 1300                 1305             


Ser Ser  Met Arg Lys Thr Asp  Trp Leu Pro Met Thr  Val Ala Ala 
    1310                 1315                 1320             


Met Gly  Val Pro Pro Leu Pro  Leu Phe Ile Phe Ser  Leu Lys Asp 
    1325                 1330                 1335             


Thr Leu  Lys Arg Arg Ser Trp  Pro Leu Asn Glu Gly  Val Met Ala 
    1340                 1345                 1350             


Val Gly  Leu Val Ser Ile Leu  Ala Ser Ser Leu Leu  Arg Asn Asp 
    1355                 1360                 1365             


Val Pro  Met Ala Gly Pro Leu  Val Ala Gly Gly Leu  Leu Ile Ala 
    1370                 1375                 1380             


Cys Tyr  Val Ile Thr Gly Thr  Ser Ala Asp Leu Thr  Val Glu Lys 
    1385                 1390                 1395             


Ala Pro  Asp Val Thr Trp Glu  Glu Glu Ala Glu Gln  Thr Gly Val 
    1400                 1405                 1410             


Ser His  Asn Leu Met Ile Thr  Val Asp Asp Asp Gly  Thr Met Arg 
    1415                 1420                 1425             


Ile Lys  Asp Asp Glu Thr Glu  Asn Ile Leu Thr Val  Leu Leu Lys 
    1430                 1435                 1440             


Thr Ala  Leu Leu Ile Val Ser  Gly Ile Phe Pro Tyr  Ser Ile Pro 
    1445                 1450                 1455             


Ala Thr  Leu Leu Val Trp His  Thr Trp Gln Lys Gln  Thr Gln Arg 
    1460                 1465                 1470             


Ser Gly  Val Leu Trp Asp Val  Pro Ser Pro Pro Glu  Thr Gln Lys 
    1475                 1480                 1485             


Ala Glu  Leu Glu Glu Gly Val  Tyr Arg Ile Lys Gln  Gln Gly Ile 
    1490                 1495                 1500             


Phe Gly  Lys Thr Gln Val Gly  Val Gly Val Gln Lys  Glu Gly Val 
    1505                 1510                 1515             


Phe His  Thr Met Trp His Val  Thr Arg Gly Ala Val  Leu Thr His 
    1520                 1525                 1530             


Asn Gly  Lys Arg Leu Glu Pro  Asn Trp Ala Ser Val  Lys Lys Asp 
    1535                 1540                 1545             


Leu Ile  Ser Tyr Gly Gly Gly  Trp Arg Leu Ser Ala  Gln Trp Gln 
    1550                 1555                 1560             


Lys Gly  Glu Glu Val Gln Val  Ile Ala Val Glu Pro  Gly Lys Asn 
    1565                 1570                 1575             


Pro Lys  Asn Phe Gln Thr Thr  Pro Gly Thr Phe Gln  Thr Thr Thr 
    1580                 1585                 1590             


Gly Glu  Ile Gly Ala Ile Ala  Leu Asp Phe Lys Pro  Gly Thr Ser 
    1595                 1600                 1605             


Gly Ser  Pro Ile Ile Asn Arg  Glu Gly Lys Val Val  Gly Leu Tyr 
    1610                 1615                 1620             


Gly Asn  Gly Val Val Thr Lys  Asn Gly Gly Tyr Val  Ser Gly Ile 
    1625                 1630                 1635             


Ala Gln  Thr Asn Ala Glu Pro  Asp Gly Pro Thr Pro  Glu Leu Glu 
    1640                 1645                 1650             


Glu Glu  Met Phe Lys Lys Arg  Asn Leu Thr Ile Met  Asp Leu His 
    1655                 1660                 1665             


Pro Gly  Ser Gly Lys Thr Arg  Lys Tyr Leu Pro Ala  Ile Val Arg 
    1670                 1675                 1680             


Glu Ala  Ile Lys Arg Arg Leu  Arg Thr Leu Ile Leu  Ala Pro Thr 
    1685                 1690                 1695             


Arg Val  Val Ala Ala Glu Met  Glu Glu Ala Leu Lys  Gly Leu Pro 
    1700                 1705                 1710             


Ile Arg  Tyr Gln Thr Thr Ala  Thr Lys Ser Glu His  Thr Gly Arg 
    1715                 1720                 1725             


Glu Ile  Val Asp Leu Met Cys  His Ala Thr Phe Thr  Met Arg Leu 
    1730                 1735                 1740             


Leu Ser  Pro Val Arg Val Pro  Asn Tyr Asn Leu Ile  Ile Met Asp 
    1745                 1750                 1755             


Glu Ala  His Phe Thr Asp Pro  Ala Ser Ile Ala Ala  Arg Gly Tyr 
    1760                 1765                 1770             


Ile Ser  Thr Arg Val Gly Met  Gly Glu Ala Ala Ala  Ile Phe Met 
    1775                 1780                 1785             


Thr Ala  Thr Pro Pro Gly Thr  Ala Asp Ala Phe Pro  Gln Ser Asn 
    1790                 1795                 1800             


Ala Pro  Ile Gln Asp Glu Glu  Arg Asp Ile Pro Glu  Arg Ser Trp 
    1805                 1810                 1815             


Asn Ser  Gly Asn Glu Trp Ile  Thr Asp Phe Ala Gly  Lys Thr Val 
    1820                 1825                 1830             


Trp Phe  Val Pro Ser Ile Lys  Ala Gly Asn Asp Ile  Ala Asn Cys 
    1835                 1840                 1845             


Leu Arg  Lys Asn Gly Lys Lys  Val Ile Gln Leu Ser  Arg Lys Thr 
    1850                 1855                 1860             


Phe Asp  Thr Glu Tyr Gln Lys  Thr Lys Leu Asn Asp  Trp Asp Phe 
    1865                 1870                 1875             


Val Val  Thr Thr Asp Ile Ser  Glu Met Gly Ala Asn  Phe Lys Ala 
    1880                 1885                 1890             


Asp Arg  Val Ile Asp Pro Arg  Arg Cys Leu Lys Pro  Val Ile Leu 
    1895                 1900                 1905             


Thr Asp  Gly Pro Glu Arg Val  Ile Leu Ala Gly Pro  Met Pro Val 
    1910                 1915                 1920             


Thr Ala  Ala Ser Ala Ala Gln  Arg Arg Gly Arg Val  Gly Arg Asn 
    1925                 1930                 1935             


Pro Gln  Lys Glu Asn Asp Gln  Tyr Ile Phe Thr Gly  Gln Pro Leu 
    1940                 1945                 1950             


Asn Asn  Asp Glu Asp His Ala  His Trp Thr Glu Ala  Lys Met Leu 
    1955                 1960                 1965             


Leu Asp  Asn Ile Asn Thr Pro  Glu Gly Ile Ile Pro  Ala Leu Phe 
    1970                 1975                 1980             


Glu Pro  Glu Arg Glu Lys Ser  Ala Ala Ile Asp Gly  Glu Tyr Arg 
    1985                 1990                 1995             


Leu Lys  Gly Glu Ser Arg Lys  Thr Phe Val Glu Leu  Met Arg Arg 
    2000                 2005                 2010             


Gly Asp  Leu Pro Val Trp Leu  Ala His Lys Val Ala  Ser Glu Gly 
    2015                 2020                 2025             


Ile Lys  Tyr Thr Asp Arg Lys  Trp Cys Phe Asp Gly  Gln Arg Asn 
    2030                 2035                 2040             


Asn Gln  Ile Leu Glu Glu Asn  Met Asp Val Glu Ile  Trp Thr Lys 
    2045                 2050                 2055             


Glu Gly  Glu Lys Lys Lys Leu  Arg Pro Arg Trp Leu  Asp Ala Arg 
    2060                 2065                 2070             


Thr Tyr  Ser Asp Pro Leu Ala  Leu Lys Glu Phe Lys  Asp Phe Ala 
    2075                 2080                 2085             


Ala Gly  Arg Lys Ser Ile Ala  Leu Asp Leu Val Thr  Glu Ile Gly 
    2090                 2095                 2100             


Arg Val  Pro Ser His Leu Ala  His Arg Thr Arg Asn  Ala Leu Asp 
    2105                 2110                 2115             


Asn Leu  Val Met Leu His Thr  Ser Glu Asp Gly Gly  Arg Ala Tyr 
    2120                 2125                 2130             


Arg His  Ala Val Glu Glu Leu  Pro Glu Thr Met Glu  Thr Leu Leu 
    2135                 2140                 2145             


Leu Leu  Gly Leu Met Ile Leu  Leu Thr Gly Gly Ala  Met Leu Phe 
    2150                 2155                 2160             


Leu Ile  Ser Gly Lys Gly Ile  Gly Lys Thr Ser Ile  Gly Leu Ile 
    2165                 2170                 2175             


Cys Val  Ile Ala Ser Ser Gly  Met Leu Trp Met Ala  Glu Val Pro 
    2180                 2185                 2190             


Leu Gln  Trp Ile Ala Ser Ala  Ile Val Leu Glu Phe  Phe Met Met 
    2195                 2200                 2205             


Val Leu  Leu Ile Pro Glu Pro  Glu Lys Gln Arg Thr  Pro Gln Asp 
    2210                 2215                 2220             


Asn Gln  Leu Ala Tyr Val Val  Ile Gly Ile Leu Thr  Leu Ala Ala 
    2225                 2230                 2235             


Thr Ile  Ala Ala Asn Glu Met  Gly Leu Leu Glu Thr  Thr Lys Arg 
    2240                 2245                 2250             


Asp Leu  Gly Met Ser Lys Glu  Pro Gly Val Val Ser  Pro Thr Ser 
    2255                 2260                 2265             


Tyr Leu  Asp Val Asp Leu His  Pro Ala Ser Ala Trp  Thr Leu Tyr 
    2270                 2275                 2280             


Ala Val  Ala Thr Thr Val Ile  Thr Pro Met Leu Arg  His Thr Ile 
    2285                 2290                 2295             


Glu Asn  Ser Thr Ala Asn Val  Ser Leu Ala Ala Ile  Ala Asn Gln 
    2300                 2305                 2310             


Ala Val  Val Leu Met Gly Leu  Asp Lys Gly Trp Pro  Ile Ser Lys 
    2315                 2320                 2325             


Met Asp  Leu Gly Val Pro Leu  Leu Ala Leu Gly Cys  Tyr Ser Gln 
    2330                 2335                 2340             


Val Asn  Pro Leu Thr Leu Thr  Ala Ala Val Leu Leu  Leu Ile Thr 
    2345                 2350                 2355             


His Tyr  Ala Ile Ile Gly Pro  Gly Leu Gln Ala Lys  Ala Thr Arg 
    2360                 2365                 2370             


Glu Ala  Gln Lys Arg Thr Ala  Ala Gly Ile Met Lys  Asn Pro Thr 
    2375                 2380                 2385             


Val Asp  Gly Ile Met Thr Ile  Asp Leu Asp Ser Val  Ile Phe Asp 
    2390                 2395                 2400             


Ser Lys  Phe Glu Lys Gln Leu  Gly Gln Val Met Leu  Leu Val Leu 
    2405                 2410                 2415             


Cys Ala  Val Gln Leu Leu Leu  Met Arg Thr Ser Trp  Ala Leu Cys 
    2420                 2425                 2430             


Glu Ala  Leu Thr Leu Ala Thr  Gly Pro Ile Thr Thr  Leu Trp Glu 
    2435                 2440                 2445             


Gly Ser  Pro Gly Lys Phe Trp  Asn Thr Thr Ile Ala  Val Ser Met 
    2450                 2455                 2460             


Ala Asn  Ile Phe Arg Gly Ser  Tyr Leu Ala Gly Ala  Gly Leu Ala 
    2465                 2470                 2475             


Phe Ser  Ile Met Lys Ser Val  Gly Thr Gly Lys Arg  Gly Thr Gly 
    2480                 2485                 2490             


Ser Gln  Gly Glu Thr Leu Gly  Glu Lys Trp Lys Lys  Lys Leu Asn 
    2495                 2500                 2505             


Gln Leu  Ser Arg Lys Glu Phe  Asp Leu Tyr Lys Lys  Ser Gly Ile 
    2510                 2515                 2520             


Thr Glu  Val Asp Arg Thr Glu  Ala Lys Glu Gly Leu  Lys Arg Gly 
    2525                 2530                 2535             


Glu Thr  Thr His His Ala Val  Ser Arg Gly Ser Ala  Lys Leu Gln 
    2540                 2545                 2550             


Trp Phe  Val Glu Arg Asn Met  Val Val Pro Glu Gly  Arg Val Ile 
    2555                 2560                 2565             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Ser Tyr Tyr  Cys Ala Gly 
    2570                 2575                 2580             


Leu Lys  Lys Val Thr Glu Val  Arg Gly Tyr Thr Lys  Gly Gly Pro 
    2585                 2590                 2595             


Gly His  Glu Glu Pro Val Pro  Met Ser Thr Tyr Gly  Trp Asn Ile 
    2600                 2605                 2610             


Val Lys  Leu Met Ser Gly Lys  Asp Val Phe Tyr Leu  Pro Pro Glu 
    2615                 2620                 2625             


Lys Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Pro Ser 
    2630                 2635                 2640             


Pro Thr  Val Glu Glu Ser Arg  Thr Ile Arg Val Leu  Lys Met Val 
    2645                 2650                 2655             


Glu Pro  Trp Leu Lys Asn Asn  Gln Phe Cys Ile Lys  Val Leu Asn 
    2660                 2665                 2670             


Pro Tyr  Met Pro Thr Val Ile  Glu His Leu Glu Arg  Leu Gln Arg 
    2675                 2680                 2685             


Lys His  Gly Gly Met Leu Val  Arg Asn Pro Leu Ser  Arg Asn Ser 
    2690                 2695                 2700             


Thr His  Glu Met Tyr Trp Ile  Ser Asn Gly Thr Gly  Asn Ile Val 
    2705                 2710                 2715             


Ser Ser  Val Asn Met Val Ser  Arg Leu Leu Leu Asn  Arg Phe Thr 
    2720                 2725                 2730             


Met Thr  His Arg Arg Pro Thr  Ile Glu Lys Asp Val  Asp Leu Gly 
    2735                 2740                 2745             


Ala Gly  Thr Arg His Val Asn  Ala Glu Pro Glu Thr  Pro Asn Met 
    2750                 2755                 2760             


Asp Val  Ile Gly Glu Arg Ile  Lys Arg Ile Lys Glu  Glu His Asn 
    2765                 2770                 2775             


Ser Thr  Trp His Tyr Asp Asp  Glu Asn Pro Tyr Lys  Thr Trp Ala 
    2780                 2785                 2790             


Tyr His  Gly Ser Tyr Glu Val  Lys Ala Thr Gly Ser  Ala Ser Ser 
    2795                 2800                 2805             


Met Ile  Asn Gly Val Val Lys  Leu Leu Thr Lys Pro  Trp Asp Val 
    2810                 2815                 2820             


Val Pro  Met Val Thr Gln Met  Ala Met Thr Asp Thr  Thr Pro Phe 
    2825                 2830                 2835             


Gly Gln  Gln Arg Val Phe Lys  Glu Lys Val Asp Thr  Arg Thr Pro 
    2840                 2845                 2850             


Arg Pro  Met Pro Gly Thr Arg  Lys Ala Met Glu Ile  Thr Ala Glu 
    2855                 2860                 2865             


Trp Leu  Trp Arg Thr Leu Gly  Arg Asn Lys Arg Pro  Arg Leu Cys 
    2870                 2875                 2880             


Thr Arg  Glu Glu Phe Thr Lys  Lys Val Arg Thr Asn  Ala Ala Met 
    2885                 2890                 2895             


Gly Ala  Val Phe Thr Glu Glu  Asn Gln Trp Asp Ser  Ala Lys Ala 
    2900                 2905                 2910             


Ala Val  Glu Asp Glu Glu Phe  Trp Lys Leu Val Asp  Arg Glu Arg 
    2915                 2920                 2925             


Glu Leu  His Lys Leu Gly Lys  Cys Gly Ser Cys Val  Tyr Asn Met 
    2930                 2935                 2940             


Met Gly  Lys Arg Glu Lys Lys  Leu Gly Glu Phe Gly  Lys Ala Lys 
    2945                 2950                 2955             


Gly Ser  Arg Ala Ile Trp Tyr  Met Trp Leu Gly Ala  Arg Tyr Leu 
    2960                 2965                 2970             


Glu Phe  Glu Ala Leu Gly Phe  Leu Asn Glu Asp His  Trp Phe Ser 
    2975                 2980                 2985             


Arg Glu  Asn Ser Tyr Ser Gly  Val Glu Gly Glu Gly  Leu His Lys 
    2990                 2995                 3000             


Leu Gly  Tyr Ile Leu Arg Asp  Ile Ser Lys Ile Pro  Gly Gly Ala 
    3005                 3010                 3015             


Met Tyr  Ala Asp Asp Thr Ala  Gly Trp Asp Thr Arg  Ile Thr Glu 
    3020                 3025                 3030             


Asp Asp  Leu His Asn Glu Glu  Lys Ile Ile Gln Gln  Met Asp Pro 
    3035                 3040                 3045             


Glu His  Arg Gln Leu Ala Asn  Ala Ile Phe Lys Leu  Thr Tyr Gln 
    3050                 3055                 3060             


Asn Lys  Val Val Lys Val Gln  Arg Pro Thr Pro Thr  Gly Thr Val 
    3065                 3070                 3075             


Met Asp  Ile Ile Ser Arg Lys  Asp Gln Arg Gly Ser  Gly Gln Leu 
    3080                 3085                 3090             


Gly Thr  Tyr Gly Leu Asn Thr  Phe Thr Asn Met Glu  Ala Gln Leu 
    3095                 3100                 3105             


Val Arg  Gln Met Glu Gly Glu  Gly Val Leu Thr Lys  Ala Asp Leu 
    3110                 3115                 3120             


Glu Asn  Pro His Leu Leu Glu  Lys Lys Ile Thr Gln  Trp Leu Glu 
    3125                 3130                 3135             


Thr Lys  Gly Val Glu Arg Leu  Lys Arg Met Ala Ile  Ser Gly Asp 
    3140                 3145                 3150             


Asp Cys  Val Val Lys Pro Ile  Asp Asp Arg Phe Ala  Asn Ala Leu 
    3155                 3160                 3165             


Leu Ala  Leu Asn Asp Met Gly  Lys Val Arg Lys Asp  Ile Pro Gln 
    3170                 3175                 3180             


Trp Gln  Pro Ser Lys Gly Trp  His Asp Trp Gln Gln  Val Pro Phe 
    3185                 3190                 3195             


Cys Ser  His His Phe His Glu  Leu Ile Met Lys Asp  Gly Arg Lys 
    3200                 3205                 3210             


Leu Val  Val Pro Cys Arg Pro  Gln Asp Glu Leu Ile  Gly Arg Ala 
    3215                 3220                 3225             


Arg Ile  Ser Gln Gly Ala Gly  Trp Ser Leu Arg Glu  Thr Ala Cys 
    3230                 3235                 3240             


Leu Gly  Lys Ala Tyr Ala Gln  Met Trp Ser Leu Met  Tyr Phe His 
    3245                 3250                 3255             


Arg Arg  Asp Leu Arg Leu Ala  Ser Asn Ala Ile Cys  Ser Ala Val 
    3260                 3265                 3270             


Pro Val  His Trp Val Pro Thr  Ser Arg Thr Thr Trp  Ser Ile His 
    3275                 3280                 3285             


Ala His  His Gln Trp Met Thr  Thr Glu Asp Met Leu  Thr Val Trp 
    3290                 3295                 3300             


Asn Arg  Val Trp Ile Glu Glu  Asn Pro Trp Met Glu  Asp Lys Thr 
    3305                 3310                 3315             


Pro Val  Thr Thr Trp Glu Asn  Val Pro Tyr Leu Gly  Lys Arg Glu 
    3320                 3325                 3330             


Asp Gln  Trp Cys Gly Ser Leu  Ile Gly Leu Thr Ser  Arg Ala Thr 
    3335                 3340                 3345             


Trp Ala  Gln Asn Ile Pro Thr  Ala Ile Gln Gln Val  Arg Ser Leu 
    3350                 3355                 3360             


Ile Gly  Asn Glu Glu Phe Leu  Asp Tyr Met Pro Ser  Met Lys Arg 
    3365                 3370                 3375             


Phe Arg  Lys Glu Glu Glu Ser  Glu Gly Ala Ile Trp  
    3380                 3385                 3390 


<210>  4
<211>  3387
<212>  PRT
<213>  Dengue virus serotype 4

<400>  4

Met Asn Gln Arg Lys Lys Val Val Arg Pro Pro Phe Asn Met Leu Lys 
1               5                   10                  15      


Arg Glu Arg Asn Arg Val Ser Thr Pro Gln Gly Leu Val Lys Arg Phe 
            20                  25                  30          


Ser Thr Gly Leu Phe Ser Gly Lys Gly Pro Leu Arg Met Val Leu Ala 
        35                  40                  45              


Phe Ile Thr Phe Leu Arg Val Leu Ser Ile Pro Pro Thr Ala Gly Ile 
    50                  55                  60                  


Leu Lys Arg Trp Gly Gln Leu Lys Lys Asn Lys Ala Ile Lys Ile Leu 
65                  70                  75                  80  


Ile Gly Phe Arg Lys Glu Ile Gly Arg Met Leu Asn Ile Leu Asn Gly 
                85                  90                  95      


Arg Lys Arg Ser Thr Ile Thr Leu Leu Cys Leu Ile Pro Thr Val Met 
            100                 105                 110         


Ala Phe Ser Leu Ser Thr Arg Asp Gly Glu Pro Leu Met Ile Val Ala 
        115                 120                 125             


Lys His Glu Arg Gly Arg Pro Leu Leu Phe Lys Thr Thr Glu Gly Ile 
    130                 135                 140                 


Asn Lys Cys Thr Leu Ile Ala Met Asp Leu Gly Glu Met Cys Glu Asp 
145                 150                 155                 160 


Thr Val Thr Tyr Lys Cys Pro Leu Leu Val Asn Thr Glu Pro Glu Asp 
                165                 170                 175     


Ile Asp Cys Trp Cys Asn Leu Thr Ser Thr Trp Val Met Tyr Gly Thr 
            180                 185                 190         


Cys Thr Gln Ser Gly Glu Arg Arg Arg Glu Lys Arg Ser Val Ala Leu 
        195                 200                 205             


Thr Pro His Ser Gly Met Gly Leu Glu Thr Arg Ala Glu Thr Trp Met 
    210                 215                 220                 


Ser Ser Glu Gly Ala Trp Lys His Ala Gln Arg Val Glu Ser Trp Ile 
225                 230                 235                 240 


Leu Arg Asn Pro Gly Phe Ala Leu Leu Ala Gly Phe Met Ala Tyr Met 
                245                 250                 255     


Ile Gly Gln Thr Gly Ile Gln Arg Thr Val Phe Phe Val Leu Met Met 
            260                 265                 270         


Leu Val Ala Pro Ser Tyr Gly Met Arg Cys Val Gly Val Gly Asn Arg 
        275                 280                 285             


Asp Phe Val Glu Gly Val Ser Gly Gly Ala Trp Val Asp Leu Val Leu 
    290                 295                 300                 


Glu His Gly Gly Cys Val Thr Thr Met Ala Gln Gly Lys Pro Thr Leu 
305                 310                 315                 320 


Asp Phe Glu Leu Thr Lys Thr Thr Ala Lys Glu Val Ala Leu Leu Arg 
                325                 330                 335     


Thr Tyr Cys Ile Glu Ala Ser Ile Ser Asn Ile Thr Thr Ala Thr Arg 
            340                 345                 350         


Cys Pro Thr Gln Gly Glu Pro Tyr Leu Lys Glu Glu Gln Asp Gln Gln 
        355                 360                 365             


Tyr Ile Cys Arg Arg Asp Val Val Asp Arg Gly Trp Gly Asn Gly Cys 
    370                 375                 380                 


Gly Leu Phe Gly Lys Gly Gly Val Val Thr Cys Ala Lys Phe Ser Cys 
385                 390                 395                 400 


Ser Gly Lys Ile Thr Gly Asn Leu Val Gln Ile Glu Asn Leu Glu Tyr 
                405                 410                 415     


Thr Val Val Val Thr Val His Asn Gly Asp Thr His Ala Val Gly Asn 
            420                 425                 430         


Asp Thr Ser Asn His Gly Val Thr Ala Met Ile Thr Pro Arg Ser Pro 
        435                 440                 445             


Ser Val Glu Val Lys Leu Pro Asp Tyr Gly Glu Leu Thr Leu Asp Cys 
    450                 455                 460                 


Glu Pro Arg Ser Gly Ile Asp Phe Asn Glu Met Ile Leu Met Lys Met 
465                 470                 475                 480 


Lys Lys Lys Thr Trp Leu Val His Lys Gln Trp Phe Leu Asp Leu Pro 
                485                 490                 495     


Leu Pro Trp Thr Ala Gly Ala Asp Thr Ser Glu Val His Trp Asn Tyr 
            500                 505                 510         


Lys Glu Arg Met Val Thr Phe Lys Val Pro His Ala Lys Arg Gln Asp 
        515                 520                 525             


Val Thr Val Leu Gly Ser Gln Glu Gly Ala Met His Ser Ala Leu Ala 
    530                 535                 540                 


Gly Ala Thr Glu Val Asp Ser Gly Asp Gly Asn His Met Phe Ala Gly 
545                 550                 555                 560 


His Leu Lys Cys Lys Val Arg Met Glu Lys Leu Arg Ile Lys Gly Met 
                565                 570                 575     


Ser Tyr Thr Met Cys Ser Gly Lys Phe Ser Ile Asp Lys Glu Met Ala 
            580                 585                 590         


Glu Thr Gln His Gly Thr Thr Val Val Lys Val Lys Tyr Glu Gly Ala 
        595                 600                 605             


Gly Ala Pro Cys Lys Val Pro Ile Glu Ile Arg Asp Val Asn Lys Glu 
    610                 615                 620                 


Lys Val Val Gly Arg Ile Ile Ser Ser Thr Pro Leu Ala Glu Asn Thr 
625                 630                 635                 640 


Asn Ser Val Thr Asn Ile Glu Leu Glu Pro Pro Phe Gly Asp Ser Tyr 
                645                 650                 655     


Ile Val Ile Gly Val Gly Asn Ser Ala Leu Thr Leu His Trp Phe Arg 
            660                 665                 670         


Lys Gly Ser Ser Ile Gly Lys Met Phe Glu Ser Thr Tyr Arg Gly Ala 
        675                 680                 685             


Lys Arg Met Ala Ile Leu Gly Glu Thr Ala Trp Asp Phe Gly Ser Val 
    690                 695                 700                 


Gly Gly Leu Phe Thr Ser Leu Gly Lys Ala Val His Gln Val Phe Gly 
705                 710                 715                 720 


Ser Val Tyr Thr Thr Met Phe Gly Gly Val Ser Trp Met Ile Arg Ile 
                725                 730                 735     


Leu Ile Gly Phe Leu Val Leu Trp Ile Gly Thr Asn Ser Arg Asn Thr 
            740                 745                 750         


Ser Met Ala Met Thr Cys Ile Ala Val Gly Gly Ile Thr Leu Phe Leu 
        755                 760                 765             


Gly Phe Thr Val Gln Ala Asp Met Gly Cys Val Ala Ser Trp Ser Gly 
    770                 775                 780                 


Lys Glu Leu Lys Cys Gly Ser Gly Ile Phe Val Val Asp Asn Val His 
785                 790                 795                 800 


Thr Trp Thr Glu Gln Tyr Lys Phe Gln Pro Glu Ser Pro Ala Arg Leu 
                805                 810                 815     


Ala Ser Ala Ile Leu Asn Ala His Lys Asp Gly Val Cys Gly Ile Arg 
            820                 825                 830         


Ser Thr Thr Arg Leu Glu Asn Val Met Trp Lys Gln Ile Thr Asn Glu 
        835                 840                 845             


Leu Asn Tyr Val Leu Trp Glu Gly Gly His Asp Leu Thr Val Val Ala 
    850                 855                 860                 


Gly Asp Val Lys Gly Val Leu Thr Lys Gly Lys Arg Ala Leu Thr Pro 
865                 870                 875                 880 


Pro Val Ser Asp Leu Lys Tyr Ser Trp Lys Thr Trp Gly Lys Ala Lys 
                885                 890                 895     


Ile Phe Thr Pro Glu Ala Arg Asn Ser Thr Phe Leu Ile Asp Gly Pro 
            900                 905                 910         


Asp Thr Ser Glu Cys Pro Asn Glu Arg Arg Ala Trp Asn Ser Leu Glu 
        915                 920                 925             


Val Glu Asp Tyr Gly Phe Gly Met Phe Thr Thr Asn Ile Trp Met Lys 
    930                 935                 940                 


Phe Arg Glu Gly Ser Ser Glu Val Cys Asp His Arg Leu Met Ser Ala 
945                 950                 955                 960 


Ala Ile Lys Asp Gln Lys Ala Val His Ala Asp Met Gly Tyr Trp Ile 
                965                 970                 975     


Glu Ser Ser Lys Asn Gln Thr Trp Gln Ile Glu Lys Ala Ser Leu Ile 
            980                 985                 990         


Glu Val Lys Thr Cys Leu Trp Pro  Lys Thr His Thr Leu  Trp Ser Asn 
        995                 1000                 1005             


Gly Val  Leu Glu Ser Gln Met  Leu Ile Pro Lys Ser  Tyr Ala Gly 
    1010                 1015                 1020             


Pro Phe  Ser Gln His Asn Tyr  Arg Gln Gly Tyr Ala  Thr Gln Thr 
    1025                 1030                 1035             


Val Gly  Pro Trp His Leu Gly  Lys Leu Glu Ile Asp  Phe Gly Glu 
    1040                 1045                 1050             


Cys Pro  Gly Thr Thr Val Thr  Ile Gln Glu Asp Cys  Asp His Arg 
    1055                 1060                 1065             


Gly Pro  Ser Leu Arg Thr Thr  Thr Ala Ser Gly Lys  Leu Val Thr 
    1070                 1075                 1080             


Gln Trp  Cys Cys Arg Ser Cys  Thr Met Pro Pro Leu  Arg Phe Leu 
    1085                 1090                 1095             


Gly Glu  Asp Gly Cys Trp Tyr  Gly Met Glu Ile Arg  Pro Leu Ser 
    1100                 1105                 1110             


Glu Lys  Glu Glu Asn Met Val  Lys Ser Gln Val Thr  Ala Gly Gln 
    1115                 1120                 1125             


Gly Thr  Ser Glu Thr Phe Ser  Met Gly Leu Leu Cys  Leu Thr Leu 
    1130                 1135                 1140             


Phe Val  Glu Glu Cys Leu Arg  Arg Arg Val Thr Arg  Lys His Met 
    1145                 1150                 1155             


Ile Leu  Val Val Val Ile Thr  Leu Cys Ala Ile Ile  Leu Gly Gly 
    1160                 1165                 1170             


Leu Thr  Trp Met Asp Leu Leu  Arg Ala Leu Ile Met  Leu Gly Asp 
    1175                 1180                 1185             


Thr Met  Ser Gly Arg Ile Gly  Gly Gln Ile His Leu  Ala Ile Met 
    1190                 1195                 1200             


Ala Val  Phe Lys Met Ser Pro  Gly Tyr Val Leu Gly  Val Phe Leu 
    1205                 1210                 1215             


Arg Lys  Leu Thr Ser Arg Glu  Thr Ala Leu Met Val  Ile Gly Met 
    1220                 1225                 1230             


Ala Met  Thr Thr Val Leu Ser  Ile Pro His Asp Leu  Met Glu Leu 
    1235                 1240                 1245             


Ile Asp  Gly Ile Ser Leu Gly  Leu Ile Leu Leu Lys  Ile Val Thr 
    1250                 1255                 1260             


Gln Phe  Asp Asn Thr Gln Val  Gly Thr Leu Ala Leu  Ser Leu Thr 
    1265                 1270                 1275             


Phe Ile  Arg Ser Thr Met Pro  Leu Val Met Ala Trp  Arg Thr Ile 
    1280                 1285                 1290             


Met Ala  Val Leu Phe Val Val  Thr Leu Ile Pro Leu  Cys Arg Thr 
    1295                 1300                 1305             


Ser Cys  Leu Gln Lys Gln Ser  His Trp Val Glu Ile  Thr Ala Leu 
    1310                 1315                 1320             


Ile Leu  Gly Ala Gln Ala Leu  Pro Val Tyr Leu Met  Thr Leu Met 
    1325                 1330                 1335             


Lys Gly  Ala Ser Arg Arg Ser  Trp Pro Leu Asn Glu  Gly Ile Met 
    1340                 1345                 1350             


Ala Val  Gly Leu Val Ser Leu  Leu Gly Ser Ala Leu  Leu Lys Asn 
    1355                 1360                 1365             


Asp Val  Pro Leu Ala Gly Pro  Met Val Ala Gly Gly  Leu Leu Leu 
    1370                 1375                 1380             


Ala Ala  Tyr Val Met Ser Gly  Ser Ser Ala Asp Leu  Ser Leu Glu 
    1385                 1390                 1395             


Lys Ala  Ala Asn Val Gln Trp  Asp Glu Met Ala Asp  Ile Thr Gly 
    1400                 1405                 1410             


Ser Ser  Pro Ile Val Glu Val  Lys Gln Asp Glu Asp  Gly Ser Phe 
    1415                 1420                 1425             


Ser Ile  Arg Asp Val Glu Glu  Thr Asn Met Ile Thr  Leu Leu Val 
    1430                 1435                 1440             


Lys Leu  Ala Leu Ile Thr Val  Ser Gly Leu Tyr Pro  Leu Ala Ile 
    1445                 1450                 1455             


Pro Val  Thr Met Thr Leu Trp  Tyr Met Trp Gln Val  Lys Thr Gln 
    1460                 1465                 1470             


Arg Ser  Gly Ala Leu Trp Asp  Val Pro Ser Pro Ala  Ala Thr Lys 
    1475                 1480                 1485             


Lys Ala  Ala Leu Ser Glu Gly  Val Tyr Arg Ile Met  Gln Arg Gly 
    1490                 1495                 1500             


Leu Phe  Gly Lys Thr Gln Val  Gly Val Gly Ile His  Met Glu Gly 
    1505                 1510                 1515             


Val Phe  His Thr Met Trp His  Val Thr Arg Gly Ser  Val Ile Cys 
    1520                 1525                 1530             


His Glu  Thr Gly Arg Leu Glu  Pro Ser Trp Ala Asp  Val Arg Asn 
    1535                 1540                 1545             


Asp Met  Ile Ser Tyr Gly Gly  Gly Trp Arg Leu Gly  Asp Lys Trp 
    1550                 1555                 1560             


Asp Lys  Glu Glu Asp Val Gln  Val Leu Ala Ile Glu  Pro Gly Lys 
    1565                 1570                 1575             


Asn Pro  Lys His Val Gln Thr  Lys Pro Gly Leu Phe  Lys Thr Leu 
    1580                 1585                 1590             


Thr Gly  Glu Ile Gly Ala Val  Thr Leu Asp Phe Lys  Pro Gly Thr 
    1595                 1600                 1605             


Ser Gly  Ser Pro Ile Ile Asn  Arg Lys Gly Lys Val  Ile Gly Leu 
    1610                 1615                 1620             


Tyr Gly  Asn Gly Val Val Thr  Lys Ser Gly Asp Tyr  Val Ser Ala 
    1625                 1630                 1635             


Ile Thr  Gln Ala Glu Arg Ile  Gly Glu Pro Asp Tyr  Glu Val Asp 
    1640                 1645                 1650             


Glu Asp  Ile Phe Arg Lys Lys  Arg Leu Thr Ile Met  Asp Leu His 
    1655                 1660                 1665             


Pro Gly  Ala Gly Lys Thr Lys  Arg Ile Leu Pro Ser  Ile Val Arg 
    1670                 1675                 1680             


Glu Ala  Leu Lys Arg Arg Leu  Arg Thr Leu Ile Leu  Ala Pro Thr 
    1685                 1690                 1695             


Arg Val  Val Ala Ala Glu Met  Glu Glu Ala Leu Arg  Gly Leu Pro 
    1700                 1705                 1710             


Ile Arg  Tyr Gln Thr Pro Ala  Val Lys Ser Glu His  Thr Gly Arg 
    1715                 1720                 1725             


Glu Ile  Val Asp Leu Met Cys  His Ala Thr Phe Thr  Thr Arg Leu 
    1730                 1735                 1740             


Leu Ser  Ser Thr Arg Val Pro  Asn Tyr Asn Leu Ile  Val Met Asp 
    1745                 1750                 1755             


Glu Ala  His Phe Thr Asp Pro  Ser Ser Val Ala Ala  Arg Gly Tyr 
    1760                 1765                 1770             


Ile Ser  Thr Arg Val Glu Met  Gly Glu Ala Ala Ala  Ile Phe Met 
    1775                 1780                 1785             


Thr Ala  Thr Pro Pro Gly Ala  Thr Asp Pro Phe Pro  Gln Ser Asn 
    1790                 1795                 1800             


Ser Pro  Ile Glu Asp Ile Glu  Arg Glu Ile Pro Glu  Arg Ser Trp 
    1805                 1810                 1815             


Asn Thr  Gly Phe Asp Trp Ile  Thr Asp Tyr Gln Gly  Lys Thr Val 
    1820                 1825                 1830             


Trp Phe  Val Pro Ser Ile Lys  Ala Gly Asn Asp Ile  Ala Asn Cys 
    1835                 1840                 1845             


Leu Arg  Lys Ser Gly Lys Lys  Val Ile Gln Leu Ser  Arg Lys Thr 
    1850                 1855                 1860             


Phe Asp  Thr Glu Tyr Pro Lys  Thr Lys Leu Thr Asp  Trp Asp Phe 
    1865                 1870                 1875             


Val Val  Thr Thr Asp Ile Ser  Glu Met Gly Ala Asn  Phe Arg Ala 
    1880                 1885                 1890             


Gly Arg  Val Ile Asp Pro Arg  Arg Cys Leu Lys Pro  Val Ile Leu 
    1895                 1900                 1905             


Pro Asp  Gly Pro Glu Arg Val  Ile Leu Ala Gly Pro  Ile Pro Val 
    1910                 1915                 1920             


Thr Pro  Ala Ser Ala Ala Gln  Arg Arg Gly Arg Ile  Gly Arg Asn 
    1925                 1930                 1935             


Pro Ala  Gln Glu Asp Asp Gln  Tyr Val Phe Ser Gly  Asp Pro Leu 
    1940                 1945                 1950             


Lys Asn  Asp Glu Asp His Ala  His Trp Thr Glu Ala  Lys Met Leu 
    1955                 1960                 1965             


Leu Asp  Asn Ile Tyr Thr Pro  Glu Gly Ile Ile Pro  Thr Leu Phe 
    1970                 1975                 1980             


Gly Pro  Glu Arg Glu Lys Thr  Gln Ala Ile Asp Gly  Glu Phe Arg 
    1985                 1990                 1995             


Leu Arg  Gly Glu Gln Arg Lys  Thr Phe Val Glu Leu  Met Arg Arg 
    2000                 2005                 2010             


Gly Asp  Leu Pro Val Trp Leu  Ser Tyr Lys Val Ala  Ser Ala Gly 
    2015                 2020                 2025             


Ile Ser  Tyr Glu Asp Arg Glu  Trp Cys Phe Thr Gly  Glu Arg Asn 
    2030                 2035                 2040             


Asn Gln  Ile Leu Glu Glu Asn  Met Glu Val Glu Ile  Trp Thr Arg 
    2045                 2050                 2055             


Glu Gly  Glu Lys Lys Lys Leu  Arg Pro Arg Trp Leu  Asp Ala Arg 
    2060                 2065                 2070             


Val Tyr  Ala Asp Pro Met Ala  Leu Lys Asp Phe Lys  Glu Phe Ala 
    2075                 2080                 2085             


Ser Gly  Arg Lys Ser Ile Thr  Leu Asp Ile Leu Thr  Glu Ile Ala 
    2090                 2095                 2100             


Ser Leu  Pro Thr Tyr Leu Ser  Ser Arg Ala Lys Leu  Ala Leu Asp 
    2105                 2110                 2115             


Asn Ile  Val Met Leu His Thr  Thr Glu Arg Gly Gly  Arg Ala Tyr 
    2120                 2125                 2130             


Gln His  Ala Leu Asn Glu Leu  Pro Glu Ser Leu Glu  Thr Leu Met 
    2135                 2140                 2145             


Leu Val  Ala Leu Leu Gly Ala  Met Thr Ala Gly Ile  Phe Leu Phe 
    2150                 2155                 2160             


Phe Met  Gln Gly Lys Gly Ile  Gly Lys Leu Ser Met  Gly Leu Ile 
    2165                 2170                 2175             


Thr Ile  Ala Val Ala Ser Gly  Leu Leu Trp Val Ala  Glu Ile Gln 
    2180                 2185                 2190             


Pro Gln  Trp Ile Ala Ala Ser  Ile Ile Leu Glu Phe  Phe Leu Met 
    2195                 2200                 2205             


Val Leu  Leu Ile Pro Glu Pro  Glu Lys Gln Arg Thr  Pro Gln Asp 
    2210                 2215                 2220             


Asn Gln  Leu Ile Tyr Val Ile  Leu Thr Ile Leu Thr  Ile Ile Gly 
    2225                 2230                 2235             


Leu Ile  Ala Ala Asn Glu Met  Gly Leu Ile Glu Lys  Thr Lys Thr 
    2240                 2245                 2250             


Asp Phe  Gly Phe Tyr Gln Val  Lys Thr Glu Thr Thr  Ile Leu Asp 
    2255                 2260                 2265             


Val Asp  Leu Arg Pro Ala Ser  Ala Trp Thr Leu Tyr  Ala Val Ala 
    2270                 2275                 2280             


Thr Thr  Ile Leu Thr Pro Met  Leu Arg His Thr Ile  Glu Asn Thr 
    2285                 2290                 2295             


Ser Ala  Asn Leu Ser Leu Ala  Ala Ile Ala Asn Gln  Ala Ala Val 
    2300                 2305                 2310             


Leu Met  Gly Leu Gly Lys Gly  Trp Pro Leu His Arg  Met Asp Leu 
    2315                 2320                 2325             


Gly Val  Pro Leu Leu Ala Met  Gly Cys Tyr Ser Gln  Val Asn Pro 
    2330                 2335                 2340             


Thr Thr  Leu Thr Ala Ser Leu  Val Met Leu Leu Val  His Tyr Ala 
    2345                 2350                 2355             


Ile Ile  Gly Pro Gly Leu Gln  Ala Lys Ala Thr Arg  Glu Ala Gln 
    2360                 2365                 2370             


Lys Arg  Thr Ala Ala Gly Ile  Met Lys Asn Pro Thr  Val Asp Gly 
    2375                 2380                 2385             


Ile Thr  Val Ile Asp Leu Glu  Pro Ile Ser Tyr Asp  Pro Lys Phe 
    2390                 2395                 2400             


Glu Lys  Gln Leu Gly Gln Val  Met Leu Leu Val Leu  Cys Ala Gly 
    2405                 2410                 2415             


Gln Leu  Leu Leu Met Arg Thr  Thr Trp Ala Phe Cys  Glu Val Leu 
    2420                 2425                 2430             


Thr Leu  Ala Thr Gly Pro Ile  Leu Thr Leu Trp Glu  Gly Asn Pro 
    2435                 2440                 2445             


Gly Arg  Phe Trp Asn Thr Thr  Ile Ala Val Ser Thr  Ala Asn Ile 
    2450                 2455                 2460             


Phe Arg  Gly Ser Tyr Leu Ala  Gly Ala Gly Leu Ala  Phe Ser Leu 
    2465                 2470                 2475             


Ile Lys  Asn Ala Gln Thr Pro  Arg Arg Gly Thr Gly  Thr Thr Gly 
    2480                 2485                 2490             


Glu Thr  Leu Gly Glu Lys Trp  Lys Arg Gln Leu Asn  Ser Leu Asp 
    2495                 2500                 2505             


Arg Lys  Glu Phe Glu Glu Tyr  Lys Arg Ser Gly Ile  Leu Glu Val 
    2510                 2515                 2520             


Asp Arg  Thr Glu Ala Lys Ser  Ala Leu Lys Asp Gly  Ser Lys Ile 
    2525                 2530                 2535             


Lys His  Ala Val Ser Arg Gly  Ser Ser Lys Ile Arg  Trp Ile Val 
    2540                 2545                 2550             


Glu Arg  Gly Met Val Lys Pro  Lys Gly Lys Val Val  Asp Leu Gly 
    2555                 2560                 2565             


Cys Gly  Arg Gly Gly Trp Ser  Tyr Tyr Met Ala Thr  Leu Lys Asn 
    2570                 2575                 2580             


Val Thr  Glu Val Lys Gly Tyr  Thr Lys Gly Gly Pro  Gly His Glu 
    2585                 2590                 2595             


Glu Pro  Ile Pro Met Ala Thr  Tyr Gly Trp Asn Leu  Val Lys Leu 
    2600                 2605                 2610             


His Ser  Gly Val Asp Val Phe  Tyr Lys Pro Thr Glu  Gln Val Asp 
    2615                 2620                 2625             


Thr Leu  Leu Cys Asp Ile Gly  Glu Ser Ser Ser Asn  Pro Thr Ile 
    2630                 2635                 2640             


Glu Glu  Gly Arg Thr Leu Arg  Val Leu Lys Met Val  Glu Pro Trp 
    2645                 2650                 2655             


Leu Ser  Ser Lys Pro Glu Phe  Cys Ile Lys Val Leu  Asn Pro Tyr 
    2660                 2665                 2670             


Met Pro  Thr Val Ile Glu Glu  Leu Glu Lys Leu Gln  Arg Lys His 
    2675                 2680                 2685             


Gly Gly  Asn Leu Val Arg Cys  Pro Leu Ser Arg Asn  Ser Thr His 
    2690                 2695                 2700             


Glu Met  Tyr Trp Val Ser Gly  Ala Ser Gly Asn Ile  Val Ser Ser 
    2705                 2710                 2715             


Val Asn  Thr Thr Ser Lys Met  Leu Leu Asn Arg Phe  Thr Thr Arg 
    2720                 2725                 2730             


His Arg  Lys Pro Thr Tyr Glu  Lys Asp Val Asp Leu  Gly Ala Gly 
    2735                 2740                 2745             


Thr Arg  Ser Val Ser Thr Glu  Thr Glu Lys Pro Asp  Met Thr Ile 
    2750                 2755                 2760             


Ile Gly  Arg Arg Leu Gln Arg  Leu Gln Glu Glu His  Lys Glu Thr 
    2765                 2770                 2775             


Trp His  Tyr Asp Gln Glu Asn  Pro Tyr Arg Thr Trp  Ala Tyr His 
    2780                 2785                 2790             


Gly Ser  Tyr Glu Ala Pro Ser  Thr Gly Ser Ala Ser  Ser Met Val 
    2795                 2800                 2805             


Asn Gly  Val Val Lys Leu Leu  Thr Lys Pro Trp Asp  Val Ile Pro 
    2810                 2815                 2820             


Met Val  Thr Gln Leu Ala Met  Thr Asp Thr Thr Pro  Phe Gly Gln 
    2825                 2830                 2835             


Gln Arg  Val Phe Lys Glu Lys  Val Asp Thr Arg Thr  Pro Gln Pro 
    2840                 2845                 2850             


Lys Pro  Gly Thr Arg Met Val  Met Thr Thr Thr Ala  Asn Trp Leu 
    2855                 2860                 2865             


Trp Ala  Leu Leu Gly Lys Lys  Lys Asn Pro Arg Leu  Cys Thr Arg 
    2870                 2875                 2880             


Glu Glu  Phe Ile Ser Lys Val  Arg Ser Asn Ala Ala  Ile Gly Ala 
    2885                 2890                 2895             


Val Phe  Gln Glu Glu Gln Gly  Trp Thr Ser Ala Ser  Glu Ala Val 
    2900                 2905                 2910             


Asn Asp  Ser Arg Phe Trp Glu  Leu Val Asp Lys Glu  Arg Ala Leu 
    2915                 2920                 2925             


His Gln  Glu Gly Lys Cys Glu  Ser Cys Val Tyr Asn  Met Met Gly 
    2930                 2935                 2940             


Lys Arg  Glu Lys Lys Leu Gly  Glu Phe Gly Arg Ala  Lys Gly Ser 
    2945                 2950                 2955             


Arg Ala  Ile Trp Tyr Met Trp  Leu Gly Ala Arg Phe  Leu Glu Phe 
    2960                 2965                 2970             


Glu Ala  Leu Gly Phe Leu Asn  Glu Asp His Trp Phe  Gly Arg Glu 
    2975                 2980                 2985             


Asn Ser  Trp Ser Gly Val Glu  Gly Glu Gly Leu His  Arg Leu Gly 
    2990                 2995                 3000             


Tyr Ile  Leu Glu Glu Ile Asp  Lys Lys Asp Gly Asp  Leu Met Tyr 
    3005                 3010                 3015             


Ala Asp  Asp Thr Ala Gly Trp  Asp Thr Arg Ile Thr  Glu Asp Asp 
    3020                 3025                 3030             


Leu Gln  Asn Glu Glu Leu Ile  Thr Glu Gln Met Ala  Pro His His 
    3035                 3040                 3045             


Lys Ile  Leu Ala Lys Ala Ile  Phe Lys Leu Thr Tyr  Gln Asn Lys 
    3050                 3055                 3060             


Val Val  Lys Val Leu Arg Pro  Thr Pro Arg Gly Ala  Val Met Asp 
    3065                 3070                 3075             


Ile Ile  Ser Arg Lys Asp Gln  Arg Gly Ser Gly Gln  Val Gly Thr 
    3080                 3085                 3090             


Tyr Gly  Leu Asn Thr Phe Thr  Asn Met Glu Val Gln  Leu Ile Arg 
    3095                 3100                 3105             


Gln Met  Glu Ala Glu Gly Val  Ile Thr Gln Asp Asp  Met Gln Asn 
    3110                 3115                 3120             


Pro Lys  Gly Leu Lys Glu Arg  Val Glu Lys Trp Leu  Lys Glu Cys 
    3125                 3130                 3135             


Gly Val  Asp Arg Leu Lys Arg  Met Ala Ile Ser Gly  Asp Asp Cys 
    3140                 3145                 3150             


Val Val  Lys Pro Leu Asp Glu  Arg Phe Gly Thr Ser  Leu Leu Phe 
    3155                 3160                 3165             


Leu Asn  Asp Met Gly Lys Val  Arg Lys Asp Ile Pro  Gln Trp Glu 
    3170                 3175                 3180             


Pro Ser  Lys Gly Trp Lys Asn  Trp Gln Glu Val Pro  Phe Cys Ser 
    3185                 3190                 3195             


His His  Phe His Lys Ile Phe  Met Lys Asp Gly Arg  Ser Leu Val 
    3200                 3205                 3210             


Val Pro  Cys Arg Asn Gln Asp  Glu Leu Ile Gly Arg  Ala Arg Ile 
    3215                 3220                 3225             


Ser Gln  Gly Ala Gly Trp Ser  Leu Arg Glu Thr Ala  Cys Leu Gly 
    3230                 3235                 3240             


Lys Ala  Tyr Ala Gln Met Trp  Ser Leu Met Tyr Phe  His Arg Arg 
    3245                 3250                 3255             


Asp Leu  Arg Leu Ala Ser Met  Ala Ile Cys Ser Ala  Val Pro Thr 
    3260                 3265                 3270             


Glu Trp  Phe Pro Thr Ser Arg  Thr Thr Trp Ser Ile  His Ala His 
    3275                 3280                 3285             


His Gln  Trp Met Thr Thr Glu  Asp Met Leu Lys Val  Trp Asn Arg 
    3290                 3295                 3300             


Val Trp  Ile Glu Asp Asn Pro  Asn Met Thr Asp Lys  Thr Pro Val 
    3305                 3310                 3315             


His Ser  Trp Glu Asp Ile Pro  Tyr Leu Gly Lys Arg  Glu Asp Leu 
    3320                 3325                 3330             


Trp Cys  Gly Ser Leu Ile Gly  Leu Ser Ser Arg Ala  Thr Trp Ala 
    3335                 3340                 3345             


Lys Asn  Ile His Thr Ala Ile  Thr Gln Val Arg Asn  Leu Ile Gly 
    3350                 3355                 3360             


Lys Glu  Glu Tyr Val Asp Tyr  Met Pro Val Met Lys  Arg Tyr Ser 
    3365                 3370                 3375             


Ala Pro  Ser Glu Ser Glu Gly  Val Leu 
    3380                 3385         


<210>  5
<211>  10690
<212>  DNA
<213>  Dengue virus serotype 1

<400>  5
acaagaacag tttcgaatcg gaagcttgct taacgtagtt ctaacagttt tttattagag       60

agcagatctc tgatgaacaa ccaacggaaa aagacgggtc gaccgtcttt caatatgctg      120

aaacgcgcga gaaaccgcgt gtcaactggt tcacagttgg cgaagagatt ctcaaaagga      180

ttgctttcgg gccaaggacc catgaaattg gtgatggctt ttatagcatt tctaagattt      240

ctagccatac ccccaacagc aggaattttg gctagatgga gctcattcaa gaagaatgga      300

gcgatcaaag tgttacgggg tttcaaaaaa gagatctcaa gcatgttgaa tattatgaac      360

aggaggaaaa aatctgtgac catgctcctc atgctgctgc ccacagccct ggcgttccat      420

ttgactacac gagggggaga gccacacatg atagttagta agcaggaaag aggaaagtca      480

ctgttgttta agacctctgc aggcatcaat atgtgcactc tcattgcgat ggatctggga      540

gagttatgcg aggacacaat gacctacaaa tgcccccgga tcactgaggc ggaaccagat      600

gacgttgact gctggtgcaa tgccacagac acatgggtga cctatgggac atgttctcaa      660

accggcgaac accgacgaga caaacgttcc gtggcactgg ccccacacgt gggacttggt      720

ctagaaacaa gaaccgaaac atggatgtcc tctgaaggtg cctggaaaca aatacaaaaa      780

gtggagactt gggctttgag acacccagga ttcacggtga cagccctttt tttagcacat      840

gccataggaa catccattac tcagaaaggg atcattttca ttttgctgat gctagtaaca      900

ccatcaatgg ccatgcgatg tgtgggaata ggcaacaggg acttcgttga aggactgtca      960

ggagcaacgt gggtggacgt agtattggag catggaagct gcgtcaccac catggcaaaa     1020

gataaaccaa cattggacat tgaactcttg aagacggagg tcacaaaccc tgccgtcttg     1080

cgcaaactgt gcattgaagc taaaatatca aacaccacca ccgattcaag gtgtccaaca     1140

caaggagagg ccacactggt ggaagaacaa gactcgaact ttgtgtgtcg acgaacgttt     1200

gtggacagag gctggggtaa tggctgcgga ctatttggaa aaggaagcct actgacgtgt     1260

gctaagttca agtgtgtgac aaaactagaa gggaagatag ttcaatatga aaacttaaaa     1320

tattcagtga tagtcactgt ccacactggg gaccagcacc aggtgggaaa cgagactaca     1380

gaacatggaa caattgcaac tataacacct caagctccta cgtcggaaat acagctgact     1440

gactacggag ccctcacatt ggactgctca cctagaacag ggctggactt taatgagatg     1500

gttctattga caatgaaaga aaaatcatgg cttgtccaca aacaatggtt tctagactta     1560

ccactgcctt ggacttcagg agcttcaaca tctcaagaga cttggaacag acaagatttg     1620

ctggtcacat tcaagacagc tcatgcaaag aaacaggaag tagtcgtact gggatcacag     1680

gaaggagcaa tgcacactgc gttgactggg gcgacagaaa tccagacgtc aggaacgaca     1740

acgatctttg caggacacct gaaatgcaga ctaaaaatgg ataaactgac tttaaaaggg     1800

atgtcatatg taatgtgcac aggctcattt aagctagaga aggaagtggc tgagacccag     1860

catggaactg ttctagtgca ggttaaatac gaaggaacag atgcaccatg caagatccct     1920

ttttcggccc aagatgagaa aggagtgacc cagaatggga gattgataac agccaacccc     1980

atagtcactg acaaagaaaa accagtcaac attgagacag aaccaccttt tggtgagagc     2040

tacatcgtgg taggggcagg tgaaaaagct ttgaaactga gctggttcaa gaaagggagc     2100

agcataggga aaatgttcga agcaactgcc cgaggagcac gaaggatggc tatcctggga     2160

gacaccgcat gggactttgg ctctatagga ggagtgttca catcagtggg aaaattggta     2220

caccaggttt ttggagccgc atatggggtt ctgttcagcg gtgtttcttg gaccatgaaa     2280

ataggaatag ggattctgct gacatggttg ggattaaatt caaggagcac gtcactttcg     2340

atgacgtgca ttgcggttgg catggtcaca ctgtacctag gagtcatggt tcaagcggac     2400

tcgggatgtg taatcaactg gaagggcaga gaactcaaat gtggaagtgg tatttttgtc     2460

actaatgaag tccacacttg gacagagcaa tacaaattcc aggctgactc cccaaaaaga     2520

ctgtcagcag ccattgggaa ggcatgggaa gagggcgtgt gtggaattcg atcagccacg     2580

cgtcttgaga acatcatgtg gaagcaaata tcaaatgaat tgaaccacat tctacttgaa     2640

aatgacatga aattcacagt ggttgtagga gatgctaatg gaattttggc ccaagggaaa     2700

aaaatgatta ggccacaacc catggaacat agatactcat ggaaaagctg gggaaaagcc     2760

aaaatcatag gagcagacat acagaatagc accttcatca tcgacggccc agatactcca     2820

gaatgccccg atgaccaaag agcgtggaac atttgggaag ttgaagacta tgggtttgga     2880

attttcacga caaacatatg gctgaaattg cgcgactcct acacccaaat gtgtgaccac     2940

cggctaatgt ccgctgccat caaagacagc aaggcagtcc atgctgacat ggggtactgg     3000

atagaaagtg aaaagaacga gacctggaag ctagcgagag cctccttcat agaagtcaag     3060

acatgtatct ggccaaaatc ccacactcta tggagtaatg gagttttgga aagtgaaatg     3120

ataatcccaa agatatatgg aggaccaata tctcagcaca actacagacc agggtatttc     3180

acacaaacag cagggccatg gcacctaggc aagttggaat tggatttcga cttgtgtgaa     3240

ggtaccacag ttgttgtgga tgaacattgt ggaaatcgag gcccatctct cagaactaca     3300

acagtcacag gaaagataat ccatgaatgg tgttgcagat cctgcacgtt acccccctta     3360

cgcttcagag gagaagacgg atgttggtat ggcatggaaa tcagaccagt taaggagaag     3420

gaggaaaacc tagttaggtc aatggtctct gcagggtcag gagaagtgga cagtttttca     3480

ctagggatac tatgcgtatc aataatgatt gaagaagtga tgagatccag atggagtaga     3540

aagatgctga tgactggaac attggctgtt ttcctccttc ttataatggg acaactgaca     3600

tggaatgacc tgattaggtt atgcatcatg gttggagcta atgcttcaga caggatgggg     3660

atgggaacaa cgtacctggc cttgatggct actttcaaaa tgagaccaat gttcgctgtt     3720

gggctactat ttcgcagact aacatccaga gaagttcttc ttctcacgat tggattaagc     3780

ctggtggcat ccgtggagtt accaaattct ttggaggagc taggggatgg acttgcaatg     3840

ggtatcatga tgttaaaatt attgactgaa tttcagccac accagttatg gaccacctta     3900

ctgtctttga catttatcaa aacaactctt tcattggatt atgcatggag gacaatggct     3960

atggtgctgt caatcgtatc tctctttcct ttatgtctgt ctacgacctc ccaaaaaaca     4020

acatggcttc cggtgctgtt aggatctttt ggatgcaaac cattaaccat gtttcttata     4080

acagaaaaca aaatctgggg aaggaaaagt tggcccctca atgaaggaat tatggctatt     4140

ggaatagtca gcattctact aagttcactc cttaaaaatg atgtgccgtt ggccggccca     4200

ctaatagctg gaggcatgct aatagcatgt tatgtcatat ccggaagctc agccgattta     4260

tcattggaga aagcggctga ggtatcctgg gaagaagaag cagaacactc tggtacctca     4320

cacaacatat tagtagaggt ccaagatgat ggaactatga aaataaaaga tgaagagagg     4380

gatgacacac tcaccatact cctcaaagca actctgctgg cagtctcagg agtgtaccca     4440

atgtcaatac cagcaactct tttcgtgtgg tatttttggc agaaaaagaa acagagatca     4500

ggagtgttat gggacacacc cagccctccg gaagtggaaa gagcagttct tgatgatggc     4560

atctatagaa tcctgcaaag aggactgttg ggcaggtccc aagtgggagt gggagttttc     4620

caggacggcg tgttccacac aatgtggcac gtcaccaggg gagctgtcct tatgtaccaa     4680

gggaagaggt tggaaccaag ctgggccagt gtcaaaaagg acttgatctc atatggagga     4740

ggttggagat ttcaaggatc atggaacacg ggagaagagg tgcaggtgat agccgttgaa     4800

ccaggaaaaa atcctaaaaa tgtacagaca acgccgggta ccttcaagac tcccgaaggc     4860

gaagttggag ccatagctct agattttaaa cccggcacat ctggatctcc catcgtgaac     4920

agagagggaa aaatagtagg tctttatgga aatggagtgg tgacaacaag tggaacctac     4980

gtcagtgcca ttgcccaagc taaaacatca caagaagggc ctctaccaga gattgaggag     5040

gaggtgttta agaaaaggaa cttaacaata atggacctgc atccaggatc gggaaaaaca     5100

agaagatatc ttccagccat agtccgtgag gccataaaaa ggaaactgcg cacgttaatc     5160

ttggctccca caagagttgt cgcctctgaa atggcagagg cgctcaaggg aatgccaata     5220

agatatcaga caacagcagt gaagagtgaa cacacaggaa gggagatagt agacctcatg     5280

tgccacgcca cttttaccat gcgtctctta tctccagtga gagttcccaa ttacaacatg     5340

attatcatgg atgaagcaca ttttaccgat ccagccagca tagcggccag agggtacatc     5400

tcaactcgag tgggtatggg tgaagcagct gcgatcttta tgacagccac tcccccagga     5460

tcggtggagg cctttccaca aagtaatgca gttatccaag atgaggaaag agacattcct     5520

gagagatcat ggaactcagg ctacgactgg atcactgatt ttccaggtaa aacagtctgg     5580

tttgttccaa gcattaagtc aggaaatgac attgctaact gtttaagaaa gaacggaaaa     5640

cgggtgatcc aattgagcag aaaaaccttt gacactgagt accagaaaac aagaaacaat     5700

gactgggact atgttgtcac aacagacatt tccgaaatgg gggcaaattt ccgggccgac     5760

agggtaatag acccaaggcg gtgcttgaaa ccagtgatac taaaagatgg tccagagcgt     5820

gtcattctag ccggaccgat gccagtgact gtggccagtg ctgcccagag aagaggaaga     5880

attggaagga accaaaacaa ggaaggtgat cagtacgttt atatgggaca gcctttaaat     5940

aatgatgagg atcacgctca ttggacagaa gcaaaaatgc tccttgacaa tataaacact     6000

ccagaaggga tcattccagc cctctttgag ccagagagag aaaagagtgc agcaatagat     6060

ggagagtaca gactgcgggg agaagcaagg aaaacgttcg tggagctcat gagaagagga     6120

gatctaccag tttggctatc ctacaaagtt gcctcagaag gtttccagta ctccgacaga     6180

aggtggtgct ttgacgggga aaggaacaac caggtgttgg aggagaacat ggacgtggag     6240

atctggacaa aggaaggaga aaggaagaaa ttgcgacccc gctggttgga tgccagaaca     6300

tactctgatc cactggccct tcgtgagttc aaagagtttg cagcaggaag aagaagtgtc     6360

tcaggtgacc taatattgga aatagggaaa cttccacaac atttgacgct aagagcccag     6420

aatgctctgg ataacttggt catgttgcac aattccgaac aaggaggaaa agcctataga     6480

catgctatgg aggaactacc agacaccata gaaacattga tgctcctagc tttgatagct     6540

gtgctgactg gtggagtgac gctgttcttc ctatcaggaa aaggtctagg gaaaacatcc     6600

attggcctgc tctgtgtgat ggcctcaagc gcactgttat ggatggccaa tgtggagcca     6660

cattggatag cggcctccat catactagag ttctttctga tggtgctgct cattccagag     6720

ccagacagac agcgcactcc acaggacaac cagctagcat acgtggtgat aggtttgtta     6780

ttcatgatac tgacagtggc agccaatgag atgggattat tggaaaccac aaagaaagac     6840

ctggggattg gctatgtagc cgccgaaaac caacaccatg ccacgatgct ggacgtagac     6900

ctacgcccag cttcagcctg gaccctctat gcagtagcca caacagttat cactcccatg     6960

atgagacaca caattgaaaa cacaacagca aacatttccc tgacagccat tgcaaaccag     7020

gcagctatat tgatgggact tgacaaggga tggccaatat cgaagatgga cataggagtt     7080

ccacttctcg ccttagggtg ctattcccag gtgaacccat tgacactgac agcggcggtg     7140

ttgatgttag tggctcatta tgccataatt ggaccaggac tgcaagcaaa ggccactaga     7200

gaagctcaaa aaaggacagc ggccggaata atgaaaaatc caaccgtaga cgggattgtt     7260

gcaatagact tggatcctgt ggtttatgat gcaaaatttg aaaaacagtt aggccaaata     7320

atgttactga tactttgtac atcacagatt ctcttgatgc ggaccacatg ggccctgtgt     7380

gaatccatca cactggctac tggacccttg accactctct gggagggatc tccaggaaaa     7440

ttctggaata ccacgatagc agtgtccatg gcaaacatct tcaggggaag ttatctagca     7500

ggagcaggtc tggccttctc gttaatgaaa tctttgggag gaggcaggag aggtacgggg     7560

gctcaaggag aaacactggg agagaaatgg aaaagacagt taaaccaact gagcaagtca     7620

gaattcaaca cctacaaaag gagtgggatt atggaggtgg acagatccga agccaaagag     7680

ggattaaaaa gaggagaaac aaccaaacat gcagtgtcga gaggaacagc caaactgagg     7740

tggtttgtgg agaggaacct cgtgaaacca gaagggaaag tcatagacct cggttgtgga     7800

agaggtggct ggtcatatta ttgtgctggg ctgaagaaag tcactgaagt caagggatac     7860

acaaaaggag gacctggaca tgaggaacct atcccaatgg cgacctatgg atggaaccta     7920

gtaaagctat actctggaaa agatgtattt tttacaccac ctgagaaatg tgataccctt     7980

ctgtgtgata taggagagtc ctctccgaat ccaactatag aagaaggaag aacgttacgt     8040

gttctaaaga tggtagaacc atggctcaga ggaaaccaat tctgcataaa aattctaaat     8100

ccttacatgc caagtgtggt agaaactctg gagcaaatgc aaagaaaaca tggagggatg     8160

ctagtgcgaa acccactctc aagaaattcc acccatgaaa tgtactgggt ttcatgtgga     8220

acaggaaaca ttgtgtcggc agtgaacatg acatccagaa tgttactgaa tcgattcaca     8280

atgactcaca ggaaaccaac atatgaaaga gacgtggact taggcgctgg aacaagacat     8340

gtggcagtgg aaccagaggt agccaaccta gatattattg gccagaggat agagaatata     8400

aaaaatgaac acaagtcaac atggtattat gatgaagaca atccatacaa aacatgggcc     8460

tatcatggat catatgaggt caaaccatca ggatcagcct catctatggt gaatggcgtg     8520

gtgagattgc tcacaaaacc atgggatgtc atccccatgg tcacacaaat agccatgacc     8580

gataccacac ccttcggaca acagagagtg tttaaagaga aagtagatac gcgcacgccg     8640

agagcaaaac gaggcacagc acaaattatg gaggtgacag ccaagtggct atggggtttc     8700

ctttccagaa acaaaaaacc cagaatctgc acaagagagg agttcacaag aaaggttagg     8760

tcaaacgcag caataggagc agtgttcgtt gatgaaaacc aatggaactc agcaaaagaa     8820

gcagtggaag acgaaaggtt ttgggatctc gtgcacagag agagggaact tcataaacag     8880

ggaaaatgtg ccacgtgtgt ctacaacatg atggggaaga gagagaaaaa attgggagag     8940

tttggaaagg caaaaggaag tcgtgcaata tggtacatgt ggctgggagc acgctttcta     9000

gagttcgaag cccttggttt catgaatgaa gatcactggt tcagtagaga gaattcattc     9060

agtggagtgg aaggagaagg actgcacaaa cttggataca tactcagaga catatcaaag     9120

atcccggggg gaaacatgta tgcagatgac acagccggat gggacacaag aataacagag     9180

gatgatcttc agaatgaggc caaaatcact gacatcatgg agcctgaaca cgctctatta     9240

gctacgtcaa tttttaagct gacctaccaa aacaaggtgg taagggtgca aagaccagca     9300

aaaaatggaa ccgtgatgga tgttatatcc agacgagacc agagaggaag tgggcaggtc     9360

ggaacctatg gcttaaatac tttcaccaat atggaggtcc aactaataag acaaatggag     9420

tctgaaggaa tctttttacc cagcgaattg gaaaccccca atctagctga gagagttctt     9480

aactggttgg aaaaacatgg cactgaaagg ctgaaaagaa tggcaattag cggagatgat     9540

tgtgtggtga aaccagttga tgacaggttt gcaacagcct taatagctct gaatgacatg     9600

ggaaaagtaa gaaaagacat accgcagtgg gaaccttcaa aaggatggaa tgactggcag     9660

caagtgcctt tctgttcaca ccatttccac cagctgatca tgaaggatgg gagggaaata     9720

gtggtgccat gccgcaacca agatgaactt gtgggcaggg ctagagtatc acaaggcgcc     9780

ggatggagcc tgagagaaac tgcttgccta ggcaagtcat atgcacaaat gtggcagctg     9840

atgtacttcc acaggagaga cctaagacta gcggctaatg ctatctgttc agctgtccca     9900

gttgactggg ttccaaccag ccgcacaacc tggtcaatcc atgctcacca tcaatggatg     9960

acaacagaag atatgttatc agtgtggaat agggtttgga tagaggaaaa cccatggatg    10020

gaggataaaa ctcatgtgtc cagctgggaa gaagtcccat acttagggaa aagggaagat    10080

caatggtgtg gatccctgat aggcttgaca gcgagggcca cttgggccac taacatacaa    10140

gtggccataa accaagtgag aaggctcatc ggaaatgaga attatctaga ttacatgaca    10200

tcaatgaaga gattcaagaa tgagagtgat cccgaagggg cactctggta agtcaacaca    10260

ctcatgaaat aaaggaaaat ggaagatcaa ataaagtaag aagtcaggcc agattaagcc    10320

atagtacgga aaaagctatg ctgcctgtga gccccgtcca aggacgtaaa atgaagtcag    10380

gccgaaagcc acggcttgag caagccgtgc tgcctgtggc tccatcgtgg ggatgtaaaa    10440

acccgggagg ctgcaaccca tggaagctgt acgcatgggg tagcagacta gtggttagag    10500

gagacccctc ccaagacaca acgcagcagc ggggcccaac accaggggaa gctgtaccct    10560

ggtggtaagg actagaggtt agaggagacc ccccgcacaa caacaaacag catattgacg    10620

ctgggagaga ccagagatcc tgctgtctct acagcatcat tccaggcaca gaacgccaga    10680

aaatggaatg                                                           10690


<210>  6
<211>  10723
<212>  DNA
<213>  Dengue virus serotype 2

<400>  6
agttgttagt ctacgtggac cgacaaagac agattctttg agggagctaa gctcaacgta       60

gttctaacag ttttttaatt agagagcaga tctctgatga ataaccaacg gaaaaaggcg      120

aaaaacacgc ctttcaatat gctgaaacgc gagagaaacc gcgtgtcgac tgtgcaacag      180

ctgacaaaga gattctcact tggaatgctg cagggacgag gaccattaaa actgttcatg      240

gccctggtgg cgttccttcg tttcctaaca atcccaccaa cagcagggat attgaagaga      300

tggggaacaa ttaaaaaatc aaaagctatt aatgttttga gagggttcag gaaagagatt      360

ggaaggatgc tgaacatctt gaataggaga cgcagatctg caggcatgat cattatgctg      420

attccaacag tgatggcgtt ccatttaacc acacgtaacg gagaaccaca catgatcgtc      480

agcagacaag agaaagggaa aagtcttctg tttaaaacag aggatggcgt gaacatgtgt      540

accctcatgg ccatggacct tggtgaattg tgtgaagaca caatcacgta caagtgtccc      600

cttctcaggc agaatgagcc agaagacata gactgttggt gcaactctac gtccacgtgg      660

gtaacttatg ggacgtgtac caccatggga gaacatagaa gagaaaaaag atcagtggca      720

ctcgttccac atgtgggaat gggactggag acacgaactg aaacatggat gtcatcagaa      780

ggggcctgga aacatgtcca gagaattgaa acttggatct tgagacatcc aggcttcacc      840

atgatggcag caatcctggc atacaccata ggaacgacac atttccaaag agccctgatt      900

ttcatcttac tgacagctgt cactccttca atgacaatgc gttgcatagg aatgtcaaat      960

agagactttg tggaaggggt ttcaggagga agctgggttg acatagtctt agaacatgga     1020

agctgtgtga cgacgatggc aaaaaacaaa ccaacattgg attttgaact gataaaaaca     1080

gaagccaaac agcctgccac cctaaggaag tactgtatag aggcaaagct aaccaacaca     1140

acaacagaat ctcgctgccc aacacaaggg gaacccagcc taaatgaaga gcaggacaaa     1200

aggttcgtct gcaaacactc catggtagac agaggatggg gaaatggatg tggactattt     1260

ggaaagggag gcattgtgac ctgtgctatg ttcagatgca aaaagaacat ggaaggaaaa     1320

gttgtgcaac cagaaaactt ggaatacacc attgtgataa cacctcactc aggggaagag     1380

catgcagtcg gaaatgacac aggaaaacat ggcaaggaaa tcaaaataac accacagagt     1440

tccatcacag aagcagaatt gacaggttat ggcactgtca caatggagtg ctctccaaga     1500

acgggcctcg acttcaatga gatggtgttg ctgcagatgg aaaataaagc ttggctggtg     1560

cacaggcaat ggttcctaga cctgccgtta ccatggttgc ccggagcgga cacacaaggg     1620

tcaaattgga tacagaaaga gacattggtc actttcaaaa atccccatgc gaagaaacag     1680

gatgttgttg ttttaggatc ccaagaaggg gccatgcaca cagcacttac aggggccaca     1740

gaaatccaaa tgtcatcagg aaacttactc ttcacaggac atctcaagtg caggctgaga     1800

atggacaagc tacagctcaa aggaatgtca tactctatgt gcacaggaaa gtttaaagtt     1860

gtgaaggaaa tagcagaaac acaacatgga acaatagtta tcagagtgca atatgaaggg     1920

gacggctctc catgcaagat cccttttgag ataatggatt tggaaaaaag acatgtctta     1980

ggtcgcctga ttacagtcaa cccaattgtg acagaaaaag atagcccagt caacatagaa     2040

gcagaacctc cattcggaga cagctacatc atcataggag tagagccggg acaactgaag     2100

ctcaactggt ttaagaaagg aagttctatc ggccaaatgt ttgagacaac aatgaggggg     2160

gcgaagagaa tggccatttt aggtgacaca gcctgggatt ttggatcctt gggaggagtg     2220

tttacatcta taggaaaggc tctccaccaa gtctttggag caatctatgg agctgccttc     2280

agtggggttt catggactat gaaaatcctc ataggagtca ttatcacatg gataggaatg     2340

aattcacgca gcacctcact gtctgtgaca ctagtattgg tgggaattgt gacactgtat     2400

ttgggagtca tggtgcaggc cgatagtggt tgcgttgtga gctggaaaaa caaagaactg     2460

aaatgtggca gtgggatttt catcacagac aacgtgcaca catggacaga acaatacaag     2520

ttccaaccag aatccccttc aaaactagct tcagctatcc agaaagccca tgaagagggc     2580

atttgtggaa tccgctcagt aacaagactg gagaatctga tgtggaaaca aataacacca     2640

gaattgaatc acattctatc agaaaatgag gtgaagttaa ctattatgac aggagacatc     2700

aaaggaatca tgcaggcagg aaaacgatct ctgcggcctc agcccactga gctgaagtat     2760

tcatggaaaa catggggcaa agcaaaaatg ctctctacag agtctcataa ccagaccttt     2820

ctcattgatg gccccgaaac agcagaatgc cccaacacaa atagagcttg gaattcgttg     2880

gaagttgaag actatggctt tggagtattc accaccaata tatggctaaa attgaaagaa     2940

aaacaggatg tattctgcga ctcaaaactc atgtcagcgg ccataaaaga caacagagcc     3000

gtccatgccg atatgggtta ttggatagaa agtgcactca atgacacatg gaagatagag     3060

aaagcctctt tcattgaagt taaaaactgc cactggccaa aatcacacac cctctggagc     3120

aatggagtgc tagaaagtga gatgataatt ccaaagaatc tcgctggacc agtgtctcaa     3180

cacaactata gaccaggcta ccatacacaa ataacaggac catggcatct aggtaagctt     3240

gagatggact ttgatttctg tgatggaaca acagtggtag tgactgagga ctgcggaaat     3300

agaggaccct ctttgagaac aaccactgcc tctggaaaac tcataacaga atggtgctgc     3360

cgatcttgca cattaccacc gctaagatac agaggtgagg atgggtgctg gtacgggatg     3420

gaaatcagac cattgaagga gaaagaagag aatttggtca actccttggt cacagctgga     3480

catgggcagg tcgacaactt ttcactagga gtcttgggaa tggcattgtt cctggaggaa     3540

atgcttagga cccgagtagg aacgaaacat gcaatactac tagttgcagt ttcttttgtg     3600

acattgatca cagggaacat gtcctttaga gacctgggaa gagtgatggt tatggtaggc     3660

gccactatga cggatgacat aggtatgggc gtgacttatc ttgccctact agcagccttc     3720

aaagtcagac caacttttgc agctggacta ctcttgagaa agctgacctc caaggaattg     3780

atgatgacta ctataggaat tgtactcctc tcccagagca ccataccaga gaccattctt     3840

gagttgactg atgcgttagc cttaggcatg atggtcctca aaatggtgag aaatatggaa     3900

aagtatcaat tggcagtgac tatcatggct atcttgtgcg tcccaaacgc agtgatatta     3960

caaaacgcat ggaaagtgag ttgcacaata ttggcagtgg tgtccgtttc cccactgctc     4020

ttaacatcct cacagcaaaa aacagattgg ataccattag cattgacgat caaaggtctc     4080

aatccaacag ctatttttct aacaaccctc tcaagaacca gcaagaaaag gagctggcca     4140

ttaaatgagg ctatcatggc agtcgggatg gtgagcattt tagccagttc tctcctaaaa     4200

aatgatattc ccatgacagg accattagtg gctggagggc tcctcactgt gtgctacgtg     4260

ctcactggac gatcggccga tttggaactg gagagagcag ccgatgtcaa atgggaagac     4320

caggcagaga tatcaggaag cagtccaatc ctgtcaataa caatatcaga agatggtagc     4380

atgtcgataa aaaatgaaga ggaagaacaa acactgacca tactcattag aacaggattg     4440

ctggtgatct caggactttt tcctgtatca ataccaatca cggcagcagc atggtacctg     4500

tgggaagtga agaaacaacg ggccggagta ttgtgggatg ttccttcacc cccacccatg     4560

ggaaaggctg aactggaaga tggagcctat agaattaagc aaaaagggat tcttggatat     4620

tcccagatcg gagccggagt ttacaaagaa ggaacattcc atacaatgtg gcatgtcaca     4680

cgtggcgctg ttctaatgca taaaggaaag aggattgaac catcatgggc ggacgtcaag     4740

aaagacctaa tatcatatgg aggaggctgg aagttagaag gagaatggaa ggaaggagaa     4800

gaagtccagg tattggcact ggagcctgga aaaaatccaa gagccgtcca aacgaaacct     4860

ggtcttttca aaaccaacgc cggaacaata ggtgctgtat ctctggactt ttctcctgga     4920

acgtcaggat ctccaattat cgacaaaaaa ggaaaagttg tgggtcttta tggtaatggt     4980

gttgttacaa ggagtggagc atatgtgagt gctatagccc agactgaaaa aagcattgaa     5040

gacaacccag agatcgaaga tgacattttc cgaaagagaa gactgaccat catggacctc     5100

cacccaggag cgggaaagac gaagagatac cttccggcca tagtcagaga agctataaaa     5160

cggggtttga gaacattaat cttggccccc actagagttg tggcagctga aatggaggaa     5220

gcccttagag gacttccaat aagataccag accccagcca tcagagctga gcacaccggg     5280

cgggagattg tggacctaat gtgtcatgcc acatttacca tgaggctgct atcaccagtt     5340

agagtgccaa actacaacct gattatcatg gacgaagccc atttcacaga cccagcaagt     5400

atagcagcta gaggatacat ctcaactcga gtggagatgg gtgaggcagc tgggattttt     5460

atgacagcca ctcccccggg aagcagagac ccatttcctc agagcaatgc accaatcata     5520

gatgaagaaa gagaaatccc tgaacgttcg tggaattccg gacatgaatg ggtcacggat     5580

tttaaaggga agactgtttg gttcgttcca agtataaaag caggaaatga tatagcagct     5640

tgcctgagga aaaatggaaa gaaagtgata caactcagta ggaagacctt tgattctgag     5700

tatgtcaaga ctagaaccaa tgattgggac ttcgtggtta caactgacat ttcagaaatg     5760

ggtgccaatt tcaaggctga gagggttata gaccccagac gctgcatgaa accagtcata     5820

ctaacagatg gtgaagagcg ggtgattctg gcaggaccta tgccagtgac ccactctagt     5880

gcagcacaaa gaagagggag aataggaaga aatccaaaaa atgagaatga ccagtacata     5940

tacatggggg aacctctgga aaatgatgaa gactgtgcac actggaaaga agctaaaatg     6000

ctcctagata acatcaacac gccagaagga atcattccta gcatgttcga accagagcgt     6060

gaaaaggtgg atgccattga tggcgaatac cgcttgagag gagaagcaag gaaaaccttt     6120

gtagacttaa tgagaagagg agacctacca gtctggttgg cctacagagt ggcagctgaa     6180

ggcatcaact acgcagacag aaggtggtgt tttgatggag tcaagaacaa ccaaatccta     6240

gaagaaaacg tggaagttga aatctggaca aaagaagggg aaaggaagaa attgaaaccc     6300

agatggttgg atgctaggat ctattctgac ccactggcgc taaaagaatt taaggaattt     6360

gcagccggaa gaaagtctct gaccctgaac ctaatcacag aaatgggtag gctcccaacc     6420

ttcatgactc agaaggcaag agacgcactg gacaacttag cagtgctgca cacggctgag     6480

gcaggtggaa gggcgtacaa ccatgctctc agtgaactgc cggagaccct ggagacattg     6540

cttttactga cacttctggc tacagtcacg ggagggatct ttttattctt gatgagcgga     6600

aggggcatag ggaagatgac cctgggaatg tgctgcataa tcacggctag catcctccta     6660

tggtacgcac aaatacagcc acactggata gcagcttcaa taatactgga gttttttctc     6720

atagttttgc ttattccaga acctgaaaaa cagagaacac cccaagacaa ccaactgacc     6780

tacgttgtca tagccatcct cacagtggtg gccgcaacca tggcaaacga gatgggtttc     6840

ctagaaaaaa cgaagaaaga tctcggattg ggaagcattg caacccagca acccgagagc     6900

aacatcctgg acatagatct acgtcctgca tcagcatgga cgctgtatgc cgtggccaca     6960

acatttgtta caccaatgtt gagacatagc attgaaaatt cctcagtgaa tgtgtcccta     7020

acagctatag ccaaccaagc cacagtgtta atgggtctcg ggaaaggatg gccattgtca     7080

aagatggaca tcggagttcc ccttctcgcc attggatgct actcacaagt caaccccata     7140

actctcacag cagctctttt cttattggta gcacattatg ccatcatagg gccaggactc     7200

caagcaaaag caaccagaga agctcagaaa agagcagcgg cgggcatcat gaaaaaccca     7260

actgtcgatg gaataacagt gattgaccta gatccaatac cttatgatcc aaagtttgaa     7320

aagcagttgg gacaagtaat gctcctagtc ctctgcgtga ctcaagtatt gatgatgagg     7380

actacatggg ctctgtgtga ggctttaacc ttagctaccg ggcccatctc cacattgtgg     7440

gaaggaaatc cagggaggtt ttggaacact accattgcgg tgtcaatggc taacattttt     7500

agagggagtt acttggccgg agctggactt ctcttttcta ttatgaagaa cacaaccaac     7560

acaagaaggg gaactggcaa cataggagag acgcttggag agaaatggaa aagccgattg     7620

aacgcattgg gaaaaagtga attccagatc tacaagaaaa gtggaatcca ggaagtggat     7680

agaaccttag caaaagaagg cattaaaaga ggagaaacgg accatcacgc tgtgtcgcga     7740

ggctcagcaa aactgagatg gttcgttgag agaaacatgg tcacaccaga agggaaagta     7800

gtggacctcg gttgtggcag aggaggctgg tcatactatt gtggaggact aaagaatgta     7860

agagaagtca aaggcctaac aaaaggagga ccaggacacg aagaacccat ccccatgtca     7920

acatatgggt ggaatctagt gcgtcttcaa agtggagttg acgttttctt catcccgcca     7980

gaaaagtgtg acacattatt gtgtgacata ggggagtcat caccaaatcc cacagtggaa     8040

gcaggacgaa cactcagagt ccttaactta gtagaaaatt ggttgaacaa caacactcaa     8100

ttttgcataa aggttctcaa cccatatatg ccctcagtca tagaaaaaat ggaagcacta     8160

caaaggaaat atggaggagc cttagtgagg aatccactct cacgaaactc cacacatgag     8220

atgtactggg tatccaatgc ttccgggaac atagtgtcat cagtgaacat gatttcaagg     8280

atgttgatca acagatttac aatgagatac aagaaagcca cttacgagcc ggatgttgac     8340

ctcggaagcg gaacccgtaa catcgggatt gaaagtgaga taccaaacct agatataatt     8400

gggaaaagaa tagaaaaaat aaagcaagag catgaaacat catggcacta tgaccaagac     8460

cacccataca aaacgtgggc ataccatggt agctatgaaa caaaacagac tggatcagca     8520

tcatccatgg tcaacggagt ggtcaggctg ctgacaaaac cttgggacgt cgtccccatg     8580

gtgacacaga tggcaatgac agacacgact ccatttggac aacagcgcgt ttttaaagag     8640

aaagtggaca cgagaaccca agaaccgaaa gaaggcacga agaaactaat gaaaataaca     8700

gcagagtggc tttggaaaga attagggaag aaaaagacac ccaggatgtg caccagagaa     8760

gaattcacaa gaaaggtgag aagcaatgca gccttggggg ccatattcac tgatgagaac     8820

aagtggaagt cggcacgtga ggctgttgaa gatagtaggt tttgggagct ggttgacaag     8880

gaaaggaatc tccatcttga aggaaagtgt gaaacatgtg tgtacaacat gatgggaaaa     8940

agagagaaga agctagggga attcggcaag gcaaaaggca gcagagccat atggtacatg     9000

tggcttggag cacgcttctt agagtttgaa gccctaggat tcttaaatga agatcactgg     9060

ttctccagag agaactccct gagtggagtg gaaggagaag ggctgcacaa gctaggttac     9120

attctaagag acgtgagcaa gaaagaggga ggagcaatgt atgccgatga caccgcagga     9180

tgggatacaa gaatcacact agaagaccta aaaaatgaag aaatggtaac aaaccacatg     9240

gaaggagaac acaagaaact agccgaggcc attttcaaac taacgtacca aaacaaggtg     9300

gtgcgtgtgc aaagaccaac accaagaggc acagtaatgg acatcatatc gagaagagac     9360

caaagaggta gtggacaagt tggcacctat ggactcaata ctttcaccaa tatggaagcc     9420

caactaatca gacagatgga gggagaagga gtctttaaaa gcattcagca cctaacaatc     9480

acagaagaaa tcgctgtgca aaactggtta gcaagagtgg ggcgcgaaag gttatcaaga     9540

atggccatca gtggagatga ttgtgttgtg aaacctttag atgacaggtt cgcaagcgct     9600

ttaacagctc taaatgacat gggaaagatt aggaaagaca tacaacaatg ggaaccttca     9660

agaggatgga atgattggac acaagtgccc ttctgttcac accatttcca tgagttaatc     9720

atgaaagacg gtcgcgtact cgttgttcca tgtagaaacc aagatgaact gattggcaga     9780

gcccgaatct cccaaggagc agggtggtct ttgcgggaga cggcctgttt ggggaagtct     9840

tacgcccaaa tgtggagctt gatgtacttc cacagacgcg acctcaggct ggcggcaaat     9900

gctatttgct cggcagtacc atcacattgg gttccaacaa gtcgaacaac ctggtccata     9960

catgctaaac atgaatggat gacaacggaa gacatgctga cagtctggaa cagggtgtgg    10020

attcaagaaa acccatggat ggaagacaaa actccagtgg aatcatggga ggaaatccca    10080

tacttgggga aaagagaaga ccaatggtgc ggctcattga ttgggttaac aagcagggcc    10140

acctgggcaa agaacatcca agcagcaata aatcaagtta gatcccttat aggcaatgaa    10200

gaatacacag attacatgcc atccatgaaa agattcagaa gagaagagga agaagcagga    10260

gttctgtggt agaaagcaaa actaacatga aacaaggcta gaagtcaggt cggattaagc    10320

catagtacgg aaaaaactat gctacctgtg agccccgtcc aaggacgtta aaagaagtca    10380

ggccatcata aatgccatag cttgagtaaa ctatgcagcc tgtagctcca cctgagaagg    10440

tgtaaaaaat ccgggaggcc acaaaccatg gaagctgtac gcatggcgta gtggactagc    10500

ggttagagga gacccctccc ttacaaatcg cagcaacaat gggggcccaa ggcgagatga    10560

agctgtagtc tcgctggaag gactagaggt tagaggagac ccccccgaaa caaaaaacag    10620

catattgacg ctgggaaaga ccagagatcc tgctgtctcc tcagcatcat tccaggcaca    10680

gaacgccaga aaatggaatg gtgctgttga atcaacaggt tct                      10723


<210>  7
<211>  10707
<212>  DNA
<213>  Dengue virus serotype 3

<400>  7
agttgttagt ctacgtggac cgacaagaac agtttcgact cggaagcttg cttaacgtag       60

tgctgacagt tttttattag agagcagatc tctgatgaac aaccaacgga agaagacggg      120

aaaaccgtct atcaatatgc tgaaacgcgt gagaaaccgt gtgtcaactg gatcacagtt      180

ggcgaagaga ttctcaaaag gactgctgaa cggccaggga ccaatgaaat tggttatggc      240

gttcatagct ttcctcagat ttctagccat tccaccaaca gcaggagtct tggctagatg      300

gggaaccttc aagaagtcgg gggccattaa ggtcctgaaa ggcttcaaga aggagatctc      360

aaacatgctg agcataatca accaacggaa aaagacatcg ctctgtctca tgatgatatt      420

gccagcagca cttgctttcc acttgacttc acgagatgga gagccgcgca tgattgtggg      480

gaagaatgaa agaggtaaat ccctactttt taagacagcc tctggaatca acatgtgcac      540

actcatagcc atggatttgg gagagatgtg tgatgacacg gtcacttaca aatgccccca      600

cattaccgaa gtggaacctg aagacattga ctgctggtgc aaccttacat caacatgggt      660

gacttatgga acgtgcaatc aagctggaga gcatagacgc gacaagagat cagtggcgtt      720

agctccccat gtcggcatgg gactggacac acgcacccaa acctggatgt cggctgaagg      780

agcttggaga caagtcgaga aggtagagac atgggccctt aggcacccag ggttcaccat      840

actagcccta tttctcgccc attacatagg cacttccctg acccagaagg tggttatttt      900

catattatta atgctggtca ccccatccat gacaatgaga tgtgtgggag taggaaacag      960

agattttgtg gaagggctat caggagctac gtgggttgac gtggtgctcg agcacggggg     1020

gtgtgtgact accatggcta agaacaagcc cacgctggat atagagcttc agaagaccga     1080

ggccacccaa ctggcgaccc taaggaagct atgcattgag gggaaaatta ccaacataac     1140

aactgactca agatgtccta cccaagggga agcggttttg cctgaggagc aggaccagaa     1200

ctacgtgtgt aagcatacat acgtagacag aggttggggg aacggttgtg gtttgtttgg     1260

caaaggaagc ttggtaacat gtgcgaaatt tcaatgcctg gaaccaatag agggaaaagt     1320

ggtgcaatat gagaacctca aatacaccgt catcattaca gtgcacacag gagaccaaca     1380

ccaggtggga aatgaaacgc aaggagtcac ggctgagata acacctcagg catcaaccac     1440

tgaagccatc ttgcctgaat atggaaccct tgggctagaa tgctcaccac ggacaggttt     1500

ggatttcaat gaaatgatct tactaacaat gaagaacaaa gcatggatgg tacatagaca     1560

atggttcttt gacctacctc taccatgggc atcaggagct acaacagaaa caccaacctg     1620

gaacaggaag gagcttcttg tgacattcaa aaacgcacat gcgaaaaaac aagaagtagt     1680

tgtccttgga tcgcaagagg gagcaatgca taccgcactg acaggagcta cagaaatcca     1740

aaactcagga ggcacaagca ttttcgcggg gcacttaaaa tgtagactta agatggacaa     1800

attggaactc aaggggatga gctatgcaat gtgcacgaat acctttgtgt tgaagaaaga     1860

agtctcagaa acgcagcacg ggacaatact cattaaggtt gagtacaaag gggaagatgc     1920

accttgcaag attccctttt ccacagagga tggacaaggg aaagctcata atggcagact     1980

gatcacagcc aaccctgtgg tgactaagaa ggaggagcct gtcaatattg aggctgaacc     2040

tccttttggg gaaagcaata tagtaattgg aattggagac aacgccttga aaatcaactg     2100

gtacaagaag gggagctcga ttgggaagat gttcgaggcc actgaaaggg gtgcaaggcg     2160

catggccatc ttgggagaca cagcttggga ctttggatca gtgggtggtg ttctgaactc     2220

attaggcaaa atggtgcacc aaatatttgg aagtgcttat acagccctgt tcagtggagt     2280

ctcttgggtg atgaaaattg gaataggtgt cctcttgact tggatagggt tgaattcaaa     2340

aaacacatcc atgtcatttt catgcattgc gataggaatc attacactct atctgggagc     2400

tgtggtacaa gctgacatgg ggtgtgtcat aaactggaag ggcaaagaac tcaaatgtgg     2460

aagcggaatt ttcgtcacca atgaggtcca tacctggaca gagcaataca aattccaagc     2520

agactcccca aaaagattgg caacagccat tgcaggcgcc tgggagaatg gagtgtgtgg     2580

aattaggtca acaaccagaa tggagaatct cttgtggaag caaatagcca atgaactgaa     2640

ctacatatta tgggaaaaca atatcaaatt aacggtagtt gtgggcgata cacttggggt     2700

cttagagcaa gggaaaagaa cactaacacc acaacccatg gagctaaaat actcatggaa     2760

aacgtgggga aaggcaaaaa tagtgacagc tgaaacacaa aattcctctt tcataataga     2820

cgggccaaac acaccggagt gtccaagtgc ctcaagagca tggaatgtgt gggaggtgga     2880

agattacggg ttcggagtct tcacaaccaa catatggctg aaactccgag aggtctacac     2940

ccaactatgt gaccataggc taatgtcggc agctgtcaag gatgagaggg ccgtgcatgc     3000

cgacatgggc tactggatag aaagccaaaa gaatggaagt tggaagctag aaaaagcatc     3060

cctcatagag gtaaaaacct gcacatggcc aaaatcacac actctctgga ctaatggtgt     3120

gctagagagt gacatgatca tcccaaagag tctagctggt cctatctcac aacacaacta     3180

caggcccggg taccacaccc aaacggcagg accctggcac ttaggaaaat tggagctgga     3240

cttcaactac tgtgaaggaa caacagttgt catcacagaa agctgtggga caagaggccc     3300

atcattgaga acaacaacag tgtcagggaa gttgatacac gaatggtgtt gccgctcgtg     3360

cacacttccc cccctgcgat acatgggaga agacggctgc tggtatggca tggaaatcag     3420

acccatcagt gagaaagaag agaacatggt aaagtcttta gtctcagcgg gaagtggaaa     3480

ggtggacaac ttcacaatgg gtgtcttgtg tttggcaatc ctctttgaag aggtgttgag     3540

aggaaaattt gggaagaaac acatgattgc aggggttttc tttacgtttg tgctccttct     3600

ctcagggcaa ataacatgga gagacatggc gcacacacta ataatgatcg ggtccaacgc     3660

ctctgacagg atgggaatgg gcgtcaccta cctagctcta attgcaacat ttaaaatcca     3720

gccattcttg gctttgggat ttttcctaag aaagctgaca tctagagaaa atttattgtt     3780

aggagttggg ttggccatgg caacaacgtt acaactgcca gaggacattg aacaaatggc     3840

aaatggagtc gctctggggc tcatggctct taaactgata acacaatttg aaacatacca     3900

attgtggacg gcattagtct ccttaacgtg ttcaaacaca atttttacgt tgactgttgc     3960

ctggagaaca gccactctga ttttggccgg agtttcgctt ttaccagtgt gccagtcttc     4020

aagcatgagg aaaacagatt ggctcccaat gacagtggca gctatgggag ttccacccct     4080

tccacttttt atttttagct tgaaagacac actcaaaagg agaagctggc cactgaatga     4140

aggggtgatg gctgttgggc ttgtgagcat tctggccagt tctctcctta gaaatgatgt     4200

gcccatggct ggaccattag tggccggggg cttgctgata gcgtgctacg tcataactgg     4260

cacgtcagcg gacctcactg tagaaaaagc cccagatgta acatgggagg aagaggctga     4320

gcagacagga gtgtcccaca acttaatgat cacagttgat gatgatggaa caatgagaat     4380

aaaagatgat gagactgaga acatcctaac agtgctttta aaaacagcat tactaatagt     4440

atcaggcatt tttccatact ccatacccgc aacattgttg gtctggcaca cttggcaaaa     4500

acaaacccaa agatccggcg ttttatggga cgtacccagc cccccagaga cacagaaagc     4560

agaactggaa gaaggggttt ataggatcaa acagcaagga atttttggga aaacccaagt     4620

aggggttgga gtacagaaag aaggagtctt ccacaccatg tggcacgtca caagaggggc     4680

agtgttgaca cataatggga aaagactgga accaaactgg gctagtgtga aaaaagatct     4740

gatttcatat ggaggaggat ggagactgag cgcacaatgg caaaaggggg aggaggtgca     4800

ggttattgcc gtagagccag ggaagaaccc aaagaacttt caaaccacgc caggcacttt     4860

ccagactact acaggggaaa taggagcaat tgcactggat ttcaagcctg gaacttcagg     4920

atctcctatc ataaatagag agggaaaggt agtgggactg tatggcaatg gagtggttac     4980

aaagaatggt ggctatgtca gcggaatagc gcaaacaaat gcagaaccag atggaccgac     5040

accagagttg gaagaagaga tgttcaaaaa gcgaaacctg accataatgg atcttcatcc     5100

tgggtcagga aagacacgga aataccttcc agctattgtc agagaggcaa tcaagagacg     5160

tttaagaacc ttaattttgg caccgacaag ggtggttgca gctgagatgg aagaagcatt     5220

gaaagggctc ccaataaggt accaaacaac agcaacaaaa tctgaacaca caggaagaga     5280

gattgttgat ctaatgtgcc acgcaacgtt cacaatgcgt ttgctgtcac cagttagggt     5340

tccaaattac aacttgataa taatggatga ggcccatttc acagacccag ccagtatagc     5400

ggctagaggg tacatatcaa ctcgtgttgg aatgggagag gcagccgcaa tcttcatgac     5460

agcaacaccc cctggaacag ctgatgcctt tcctcagagc aacgctccaa ttcaagatga     5520

agaaagggac ataccagaac gctcatggaa ttcaggcaat gaatggatta ccgacttcgc     5580

tgggaaaacg gtgtggtttg tccctagcat taaagccgga aatgacatag caaactgctt     5640

gcgaaaaaac gggaaaaaag tcattcaact tagtaggaag acttttgaca cagaatatca     5700

gaagactaaa ctgaatgatt gggactttgt ggtgacaact gacatttcag aaatgggggc     5760

caatttcaaa gcagatagag tgatcgaccc aagaagatgt ctcaaaccag tgatcttgac     5820

agatggacca gagcgggtga tcctggccgg accaatgcca gtcaccgcgg cgagtgctgc     5880

gcaaaggaga gggagagttg gcaggaaccc acaaaaagag aatgaccagt acatattcac     5940

gggccagcct ctcaacaatg atgaagacca tgctcactgg acagaagcaa aaatgctgct     6000

ggacaacatc aacacaccag aagggattat accagctctc tttgaaccag aaagggagaa     6060

gtcagccgcc atagacggtg agtatcgcct gaagggtgag tccaggaaga ctttcgtgga     6120

actcatgagg aggggtgacc ttccagtttg gttagcccat aaagtagcat cagaaggaat     6180

caaatacaca gatagaaaat ggtgctttga tgggcaacgc aataatcaaa ttttagagga     6240

gaacatggat gtggaaattt ggacaaagga aggagaaaag aaaaaattga gacctaggtg     6300

gcttgatgcc cgcacttatt cagatccatt ggcactcaag gaattcaagg actttgcggc     6360

tggcagaaag tcaatcgccc ttgatcttgt gacagaaata ggaagagtgc cttcacatct     6420

agcccacaga acaagaaacg ctctggacaa tctggtgatg ctgcatacgt cagaagatgg     6480

cggtagggct tacaggcatg cggtggagga actaccagaa acaatggaaa cactcctact     6540

cttgggacta atgatcttgt tgacaggtgg agcaatgctt ttcttgatat caggtaaagg     6600

gattggaaag acttcaatag gactcatttg tgtaatcgct tccagcggca tgttgtggat     6660

ggccgaagtt ccactccaat ggatcgcgtc ggctatagtc ctggagtttt ttatgatggt     6720

gttgctcata ccagaaccag aaaagcagag aaccccccaa gacaaccaac tcgcatatgt     6780

cgtgataggc atacttacat tggctgcaac aatagcagcc aatgaaatgg gactgctgga     6840

aaccacaaag agagacttag gaatgtctaa ggagccaggt gttgtttctc caaccagcta     6900

tttggatgtg gacttgcacc cagcatcagc ctggacattg tacgccgtgg ccactacagt     6960

aataacacca atgttaagac ataccataga gaattctaca gcaaatgtgt ccctggcagc     7020

tatagccaac caggcagtgg tcctgatggg tttggacaaa ggatggccaa tatcaaaaat     7080

ggacttaggc gtgccactac tggcactggg ttgctattca caagtgaacc cactgactct     7140

aactgcggca gtacttttgc taatcacaca ttatgctatc ataggtccag gattgcaagc     7200

aaaagccacc cgtgaagctc agaaaaggac agctgctgga ataatgaaga atccaacagt     7260

ggatgggata atgacaatag acctagattc tgtaatattt gattcaaaat ttgaaaaaca     7320

actgggacag gttatgctcc tggttttgtg cgcagtccaa ctcttgctaa tgagaacatc     7380

atgggccttg tgtgaagctt taactctagc tacaggacca ataacaacac tctgggaagg     7440

atcacctggt aagttctgga acaccacgat agctgtttcc atggcgaaca tttttagagg     7500

gagctattta gcaggagctg ggcttgcttt ttctattatg aaatcagttg gaacaggaaa     7560

aagaggaaca ggctcacaag gtgaaacttt aggagaaaaa tggaaaaaga aattaaatca     7620

attatcccgg aaagagtttg acctttacaa gaaatctgga atcactgaag tggatagaac     7680

agaagccaaa gaagggttga aaagaggaga gacaacacat catgccgtgt cccgaggtag     7740

cgcaaaactt caatggtttg tggaaagaaa catggtcgtt cccgaaggaa gagtcataga     7800

cttgggctgt ggaagaggag gctggtcata ttactgtgca ggactgaaaa aagtcacaga     7860

agtgcgagga tacacaaaag gcggtccagg acacgaagaa ccagtaccta tgtctacata     7920

tggatggaac atagttaagt taatgagcgg aaaggatgtg ttctatctcc cacctgaaaa     7980

gtgtgatacc ctgttgtgtg acattggaga atcttcacca agcccaacag tggaagagag     8040

cagaactata agagttttga agatggttga accatggcta aaaaacaacc agttttgcat     8100

taaagttttg aacccttaca tgccaactgt gattgagcac ctagaaagac tacaaaggaa     8160

acatggagga atgcttgtga gaaatccact ttcacgaaac tccacgcacg aaatgtactg     8220

gatatctaat ggcacaggta acattgtctc ttcagtcaac atggtgtcta gattgctact     8280

gaacaggttc acgatgacac acaggagacc caccatagag aaagatgtgg atttaggagc     8340

aggaactcga catgttaatg cggaaccaga aacacccaac atggatgtca ttggggaaag     8400

aataaaaagg atcaaggagg agcataattc aacatggcac tatgatgacg aaaaccccta     8460

caaaacgtgg gcttaccatg gatcctatga agtcaaagcc acaggctcag cctcctccat     8520

gataaatgga gtcgtgaaac tcctcaccaa accatgggat gtggtgccca tggtgacaca     8580

gatggcaatg acagacacaa ctccatttgg ccagcagaga gtctttaaag agaaagtgga     8640

caccaggacg cccaggccca tgccagggac aagaaaggct atggagatca cagcggagtg     8700

gctctggaga accctgggaa ggaacaaaag acccagatta tgcacaaggg aagagtttac     8760

aaaaaaggtc agaactaacg cagccatggg cgccgttttc acagaggaga accaatggga     8820

cagtgcgaaa gctgctgttg aggatgaaga attttggaaa cttgtggaca gagaacgtga     8880

actccacaaa ttgggcaaat gtggaagctg cgtttataac atgatgggca agagagagaa     8940

aaaacttgga gagtttggca aagcaaaagg cagtagagct atatggtaca tgtggttggg     9000

agccaggtac cttgagttcg aagcccttgg attcttaaat gaagaccact ggttctcgcg     9060

tgaaaactct tacagtggag tagaaggaga aggactgcac aagctaggct acatattaag     9120

ggacatttcc aagatacccg gaggagccat gtatgctgat gacacagctg gttgggacac     9180

aagaataaca gaagatgacc tgcacaatga ggaaaagatc atacagcaaa tggaccctga     9240

acacaggcag ttagcgaacg ctatattcaa gctcacatac caaaacaaag tggtcaaagt     9300

tcaacgaccg actccaacgg gcacggtaat ggatattata tctaggaaag accaaagggg     9360

cagtggacaa ctgggaactt atggcctgaa tacattcacc aacatggaag cccagttagt     9420

cagacaaatg gaaggagaag gtgtgctgac aaaggcagac ctcgagaacc ctcatctgct     9480

agagaagaaa atcacacaat ggttggaaac caaaggagtg gagaggttaa aaagaatggc     9540

cattagcggg gatgattgcg tggtgaaacc aatcgatgac aggttcgcta atgccctgct     9600

tgctttgaac gatatgggaa aggttcggaa agacatacct caatggcagc catcaaaggg     9660

atggcatgat tggcaacagg ttcctttctg ctcccaccac tttcatgaat tgatcatgaa     9720

agatggaaga aagttggtgg ttccctgcag accccaggac gaactaatag gaagagcaag     9780

aatctctcaa ggagcgggat ggagccttag agaaactgca tgtctgggga aagcctacgc     9840

ccaaatgtgg agtctcatgt attttcacag aagagatctc agattagcat ccaacgccat     9900

atgttcagca gtaccagtcc actgggttcc cacaagtaga acgacatggt ctattcatgc     9960

tcaccatcag tggatgacta cagaagacat gcttactgtt tggaacaggg tgtggataga    10020

ggaaaatcca tggatggaag acaaaactcc agttacaact tgggaaaatg ttccatatct    10080

aggaaagaga gaagaccaat ggtgtggatc acttattggt ctcacttcca gagcaacctg    10140

ggcccagaac atacccacag caattcaaca ggtgagaagc cttataggca atgaagagtt    10200

cctggactac atgccttcaa tgaagagatt caggaaggaa gaggagtcgg agggagccat    10260

ttggtaaacg taggaagtgg aaaagaggct aactgtcagg ccaccttaag ccacagtacg    10320

gaagaagctg tgctgcctgt gagccccgtc caaggacgtt aaaagaagaa gtcaggcccc    10380

aaagccacgg tttgagcaaa ccgtgctgcc tgtagctccg tcgtggggac gtaaaacctg    10440

ggaggctgca aactgtggaa gctgtacgca cggtgtagca gactagcggt tagaggagac    10500

ccctcccatg acacaacgca gcagcggggc ccgagcactg agggaagctg tacctccttg    10560

caaaggacta gaggttagag gagacccccc gcaaataaaa acagcatatt gacgctggga    10620

gagaccagag atcctgctgt ctcctcagca tcattccagg cacagaacgc cagaaaatgg    10680

aatggtgctg ttgaatcaac aggttct                                        10707


<210>  8
<211>  10649
<212>  DNA
<213>  Dengue virus serotype 4

<400>  8
agttgttagt ctgtgtggac cgacaaggac agttccaaat cggaagcttg cttaacacag       60

ttctaacagt ttgtttgaat agagagcaga tctctggaaa aatgaaccaa cgaaaaaagg      120

tggttagacc acctttcaat atgctgaaac gcgagagaaa ccgcgtatca acccctcaag      180

ggttggtgaa gagattctca accggacttt tttctgggaa aggaccctta cggatggtgc      240

tagcattcat cacgtttttg cgagtccttt ccatcccacc aacagcaggg attctgaaga      300

gatggggaca gttgaagaaa aataaggcca tcaagatact gattggattc aggaaggaga      360

taggccgcat gctgaacatc ttgaacggga gaaaaaggtc aacgataaca ttgctgtgct      420

tgattcccac cgtaatggcg ttttccctca gcacaagaga tggcgaaccc ctcatgatag      480

tggcaaaaca tgaaaggggg agacctctct tgtttaagac aacagagggg atcaacaaat      540

gcactctcat tgccatggac ttgggtgaaa tgtgtgagga cactgtcacg tataaatgcc      600

ccctactggt caataccgaa cctgaagaca ttgattgctg gtgcaacctc acgtctacct      660

gggtcatgta tgggacatgc acccagagcg gagaacggag acgagagaag cgctcagtag      720

ctttaacacc acattcagga atgggattgg aaacaagagc tgagacatgg atgtcatcgg      780

aaggggcttg gaagcatgct cagagagtag agagctggat actcagaaac ccaggattcg      840

cgctcttggc aggatttatg gcttatatga ttgggcaaac aggaatccag cgaactgtct      900

tctttgtcct aatgatgctg gtcgccccat cctacggaat gcgatgcgta ggagtaggaa      960

acagagactt tgtggaagga gtctcaggtg gagcatgggt cgacctggtg ctagaacatg     1020

gaggatgcgt cacaaccatg gcccagggaa aaccaacctt ggattttgaa ctgactaaga     1080

caacagccaa ggaagtggct ctgttaagaa cctattgcat tgaagcctca atatcaaaca     1140

taactacggc aacaagatgt ccaacgcaag gagagcctta tctgaaagag gaacaggacc     1200

aacagtacat ttgccggaga gatgtggtag acagagggtg gggcaatggc tgtggcttgt     1260

ttggaaaagg aggagttgtg acatgtgcga agttttcatg ttcggggaag ataacaggca     1320

atttggtcca aattgagaac cttgaataca cagtggttgt aacagtccac aatggagaca     1380

cccatgcagt aggaaatgac acatccaatc atggagttac agccatgata actcccaggt     1440

caccatcggt ggaagtcaaa ttgccggact atggagaact aacactcgat tgtgaaccca     1500

ggtctggaat tgactttaat gagatgattc tgatgaaaat gaaaaagaaa acatggctcg     1560

tgcataagca atggtttttg gatctgcctc ttccatggac agcaggagca gacacatcag     1620

aggttcactg gaattacaaa gagagaatgg tgacatttaa ggttcctcat gccaagagac     1680

aggatgtgac agtgctggga tctcaggaag gagccatgca ttctgccctc gctggagcca     1740

cagaagtgga ctccggtgat ggaaatcaca tgtttgcagg acatcttaag tgcaaagtcc     1800

gtatggagaa attgagaatc aagggaatgt catacacgat gtgttcagga aagttttcaa     1860

ttgacaaaga gatggcagaa acacagcatg ggacaacagt ggtgaaagtc aagtatgaag     1920

gtgctggagc tccgtgtaaa gtccccatag agataagaga tgtaaacaag gaaaaagtgg     1980

ttgggcgtat catctcatcc acccctttgg ctgagaatac caacagtgta accaacatag     2040

aattagaacc cccctttggg gacagctaca tagtgatagg tgttggaaac agcgcattaa     2100

cactccattg gttcaggaaa gggagttcca ttggcaagat gtttgagtcc acatacagag     2160

gtgcaaaacg aatggccatt ctaggtgaaa cagcttggga ttttggttcc gttggtggac     2220

tgttcacatc attgggaaag gctgtgcacc aggtttttgg aagtgtgtat acaaccatgt     2280

ttggaggagt ctcatggatg attagaatcc taattgggtt cttagtgttg tggattggca     2340

cgaactcgag gaacacttca atggctatga cgtgcatagc tgttggagga atcactctgt     2400

ttctgggctt cacagttcaa gcagacatgg gttgtgtggc gtcatggagt gggaaagaat     2460

tgaagtgtgg aagcggaatt tttgtggttg acaacgtgca cacttggaca gaacagtaca     2520

aatttcaacc agagtcccca gcgagactag cgtctgcaat attaaatgcc cacaaagatg     2580

gggtctgtgg aattagatca accacgaggc tggaaaatgt catgtggaag caaataacca     2640

acgagctaaa ctatgttctc tgggaaggag gacatgacct cactgtagtg gctggggatg     2700

tgaagggggt gttgaccaaa ggcaagagag cactcacacc cccagtgagt gatctgaaat     2760

attcatggaa gacatgggga aaagcaaaaa tcttcacccc agaagcaaga aatagcacat     2820

ttttaataga cggaccagac acctctgaat gccccaatga acgaagagca tggaactctc     2880

ttgaggtgga agactatgga tttggcatgt tcacgaccaa catatggatg aaattccgag     2940

aaggaagttc agaagtgtgt gaccacaggt taatgtcagc tgcaattaaa gatcagaaag     3000

ctgtgcatgc tgacatgggt tattggatag agagctcaaa aaaccagacc tggcagatag     3060

agaaagcatc tcttattgaa gtgaaaacat gtctgtggcc caagacccac acactgtgga     3120

gcaatggagt gctggaaagc cagatgctca ttccaaaatc atatgcgggc cctttttcac     3180

agcacaatta ccgccagggc tatgccacgc aaaccgtggg cccatggcac ttaggcaaat     3240

tagagataga ctttggagaa tgccccggaa caacagtcac aattcaggag gattgtgacc     3300

atagaggccc atctttgagg accaccactg catctggaaa actagtcacg caatggtgct     3360

gccgctcctg cacgatgcct cccttaaggt tcttgggaga agatgggtgc tggtatggga     3420

tggagattag gcccttgagt gaaaaagaag agaacatggt caaatcacag gtgacggccg     3480

gacagggcac atcagaaact ttttctatgg gtctgttgtg cctgaccttg tttgtggaag     3540

aatgcttgag gagaagagtc actaggaaac acatgatatt agttgtggtg atcactcttt     3600

gtgctatcat cctgggaggc ctcacatgga tggacttact acgagccctc atcatgttgg     3660

gggacactat gtctggtaga ataggaggac agatccacct agccatcatg gcagtgttca     3720

agatgtcacc aggatacgtg ctgggtgtgt ttttaaggaa actcacttca agagagacag     3780

cactaatggt aataggaatg gccatgacaa cggtgctttc aattccacat gaccttatgg     3840

aactcattga tggaatatca ctgggactaa ttttgctaaa aatagtaaca cagtttgaca     3900

acacccaagt gggaacctta gctctttcct tgactttcat aagatcaaca atgccattgg     3960

tcatggcttg gaggaccatt atggctgtgt tgtttgtggt cacactcatt cctttgtgca     4020

ggacaagctg tcttcaaaaa cagtctcatt gggtagaaat aacagcactc atcctaggag     4080

cccaagctct gccagtgtac ctaatgactc ttatgaaagg agcctcaaga agatcttggc     4140

ctcttaacga gggcataatg gctgtgggtt tggttagtct cttaggaagc gctcttttaa     4200

agaatgatgt ccctttagct ggcccaatgg tggcaggagg cttacttctg gcggcttacg     4260

tgatgagtgg tagctcagca gatctgtcac tagagaaggc cgccaacgtg cagtgggatg     4320

aaatggcaga cataacaggc tcaagcccaa tcgtagaagt gaagcaggat gaagatggct     4380

ctttctccat acgggacgtc gaggaaacca atatgataac ccttttggtg aaactggcac     4440

tgataacagt gtcaggtctc taccccttgg caattccagt cacaatgacc ttatggtaca     4500

tgtggcaagt gaaaacacaa agatcaggag ccctgtggga cgtcccctca cccgctgcca     4560

ctaaaaaagc cgcactgtct gaaggagtgt acaggatcat gcaaagaggg ttattcggga     4620

aaactcaggt tggagtaggg atacacatgg aaggtgtatt tcacacaatg tggcatgtaa     4680

caagaggatc agtgatctgc cacgagactg ggagattgga gccatcttgg gctgacgtca     4740

ggaatgacat gatatcatac ggtgggggat ggaggcttgg agacaaatgg gacaaagaag     4800

aagacgttca ggtcctcgcc atagaaccag gaaaaaatcc taaacatgtc caaacgaaac     4860

ctggcctttt caagacccta actggagaaa ttggagcagt aacattagat ttcaaacccg     4920

gaacgtctgg ttctcccatc atcaacagga aaggaaaagt catcggactc tatggaaatg     4980

gagtagttac caaatcaggt gattacgtca gtgccataac gcaagccgaa agaattggag     5040

agccagatta tgaagtggat gaggacattt ttcgaaagaa aagattaact ataatggact     5100

tacaccccgg agctggaaag acaaaaagaa ttcttccatc aatagtgaga gaagccttaa     5160

aaaggaggct acgaactttg attttagctc ccacgagagt ggtggcggcc gagatggaag     5220

aggccctacg tggactgcca atccgttatc agaccccagc tgtgaaatca gaacacacag     5280

gaagagagat tgtagacctc atgtgtcatg caaccttcac aacaagactt ttgtcatcaa     5340

ccagggttcc aaattacaac cttatagtga tggatgaagc acatttcacc gatccttcta     5400

gtgtcgcggc tagaggatac atctcgacca gggtggaaat gggagaggca gcagccatct     5460

tcatgaccgc aacccctccc ggagcgacag atccctttcc ccagagcaac agcccaatag     5520

aagacatcga gagggaaatt ccggaaaggt catggaacac agggttcgac tggataacag     5580

actaccaagg gaaaactgtg tggtttgttc ccagcataaa agctggaaat gacattgcaa     5640

attgtttgag aaagtcggga aagaaagtta tccagttgag taggaaaacc tttgatacag     5700

agtatccaaa aacgaaactc acggactggg actttgtggt cactacagac atatctgaaa     5760

tgggggccaa ttttagagcc gggagagtga tagaccctag aagatgcctc aagccagtta     5820

tcctaccaga tgggccagag agagtcattt tagcaggtcc tattccagtg actccagcaa     5880

gcgctgctca gagaagaggg cgaataggaa ggaacccagc acaagaagac gaccaatacg     5940

ttttctccgg agacccacta aaaaatgatg aagatcatgc ccactggaca gaagcaaaga     6000

tgctgcttga caatatctac accccagaag ggatcattcc aacattgttt ggtccggaaa     6060

gggaaaaaac ccaagccatt gatggagagt ttcgcctcag aggggaacaa aggaagactt     6120

ttgtggaatt aatgaggaga ggagaccttc cggtgtggct gagctataag gtagcttctg     6180

ctggcatttc ttacgaagat cgggaatggt gcttcacagg ggaaagaaat aaccaaattt     6240

tagaagaaaa catggaggtt gaaatttgga ctagagaggg agaaaagaaa aagctaaggc     6300

caagatggtt agatgcacgt gtatacgctg accccatggc tttgaaggat ttcaaggagt     6360

ttgccagtgg aaggaagagt ataactctcg acatcctaac agagattgcc agtttgccaa     6420

cttacctttc ctctagggcc aagctcgccc ttgataacat agtcatgctc cacacaacag     6480

aaagaggagg gagggcctat caacacgccc tgaacgaact tccggagtca ctggaaacac     6540

tcatgcttgt agctttacta ggtgctatga cagcaggcat cttcctgttt ttcatgcaag     6600

ggaaaggaat agggaaattg tcaatgggtt tgataaccat tgcggtggct agtggcttgc     6660

tctgggtagc agaaattcaa ccccagtgga tagcggcctc aatcatacta gagttttttc     6720

tcatggtact gttgataccg gaaccagaaa aacaaaggac cccacaagac aatcaattga     6780

tctacgtcat attgaccatt ctcaccatca ttggtctaat agcagccaac gagatggggc     6840

tgattgaaaa aacaaaaacg gattttgggt tttaccaggt aaaaacagaa accaccatcc     6900

tcgatgtgga cttgagacca gcttcagcat ggacgctcta tgcagtagcc accacaattc     6960

tgactcccat gctgagacac accatagaaa acacgtcggc caacctatct ctagcagcca     7020

ttgccaacca ggcagccgtc ctaatggggc ttggaaaagg atggccgctc cacagaatgg     7080

acctcggtgt gccgctgtta gcaatgggat gctattctca agtgaaccca acaaccttga     7140

cagcatcctt agtcatgctt ttagtccatt atgcaataat aggcccagga ttgcaggcaa     7200

aagccacaag agaggcccag aaaaggacag ctgctgggat catgaaaaat cccacagtgg     7260

acgggataac agtaatagat ctagaaccaa tatcctatga cccaaaattt gaaaagcaat     7320

tagggcaggt catgctacta gtcttgtgtg ctggacaact actcttgatg agaacaacat     7380

gggctttctg tgaagtcttg actttggcca caggaccaat cttgaccttg tgggagggca     7440

acccgggaag gttttggaac acgaccatag ccgtatccac cgccaacatt ttcaggggaa     7500

gttacttggc gggagctgga ctggcttttt cactcataaa gaatgcacaa acccctagga     7560

ggggaactgg gaccacagga gagacactgg gagagaagtg gaagagacag ctaaactcat     7620

tagacagaaa agagtttgaa gagtataaaa gaagtggaat actagaagtg gacaggactg     7680

aagccaagtc tgccctgaaa gatgggtcta aaatcaagca tgcagtatca agagggtcca     7740

gtaagatcag atggattgtt gagagaggga tggtaaagcc aaaagggaaa gttgtagatc     7800

ttggctgtgg gagaggagga tggtcttatt acatggcgac actcaagaac gtgactgaag     7860

tgaaagggta tacaaaagga ggtccaggac atgaagaacc gattcccatg gctacttatg     7920

gttggaattt ggtcaaactc cattcagggg ttgacgtgtt ctacaaaccc acagagcaag     7980

tggacaccct gctctgtgat attggggagt catcttctaa tccaacaata gaggaaggaa     8040

gaacattaag agttttgaag atggtggagc catggctctc ttcaaaacct gaattctgca     8100

tcaaagtcct taacccctac atgccaacag tcatagaaga gctggagaaa ctgcagagaa     8160

aacatggtgg gaaccttgtc agatgcccgc tgtccaggaa ctccacccat gagatgtatt     8220

gggtgtcagg agcgtcggga aacattgtga gctctgtgaa cacaacatca aagatgttgt     8280

tgaacaggtt cacaacaagg cataggaaac ccacttatga gaaggacgta gatcttgggg     8340

caggaacgag aagtgtctcc actgaaacag aaaaaccaga catgacaatc attgggagaa     8400

ggcttcagcg attgcaagaa gagcacaaag aaacctggca ttatgatcag gaaaacccat     8460

acagaacctg ggcgtatcat ggaagctatg aagctccttc gacaggctct gcatcctcca     8520

tggtgaacgg ggtggtaaaa ctgctaacaa aaccctggga tgtgattcca atggtgactc     8580

agttagccat gacagataca accccttttg ggcaacaaag agtgttcaaa gagaaggtgg     8640

ataccagaac accacaacca aaacccggta cacgaatggt tatgaccacg acagccaatt     8700

ggctgtgggc cctccttgga aagaagaaaa atcccagact gtgcacaagg gaagagttca     8760

tctcaaaagt tagatcaaac gcagccatag gcgcagtctt tcaggaagaa cagggatgga     8820

catcagccag tgaagctgtg aatgacagcc ggttttggga actggttgac aaagaaaggg     8880

ccctacacca ggaagggaaa tgtgaatcgt gtgtctataa catgatggga aaacgtgaga     8940

aaaagttagg agagtttggc agagccaagg gaagccgagc aatctggtac atgtggctgg     9000

gagcgcggtt tctggaattt gaagccctgg gttttttgaa tgaagatcac tggtttggca     9060

gagaaaattc atggagtgga gtggaagggg aaggtctgca cagattggga tatatcctgg     9120

aggagataga caagaaggat ggagacctaa tgtatgctga tgacacagca ggctgggaca     9180

caagaatcac tgaggatgac cttcaaaatg aggaactgat cacggaacag atggctcccc     9240

accacaagat cctagccaaa gccattttca aactaaccta tcaaaacaaa gtggtgaaag     9300

tcctcagacc cacaccgcgg ggagcggtga tggatatcat atccaggaaa gaccaaagag     9360

gtagtggaca agttggaaca tatggtttga acacattcac caacatggaa gttcaactca     9420

tccgccaaat ggaagctgaa ggagtcatca cacaagatga catgcagaac ccaaaagggt     9480

tgaaagaaag agttgagaaa tggctgaaag agtgtggtgt cgacaggtta aagaggatgg     9540

caatcagtgg agacgattgc gtggtgaagc ccctagatga gaggtttggc acttccctcc     9600

tcttcttgaa cgacatggga aaggtgagga aagacattcc gcagtgggaa ccatctaagg     9660

gatggaaaaa ctggcaagag gttccttttt gctcccacca ctttcacaag atctttatga     9720

aggatggccg ctcactagtt gttccatgta gaaaccagga tgaactgata gggagagcca     9780

gaatctcgca gggagctgga tggagcttaa gagaaacagc ctgcctgggc aaagcttacg     9840

cccagatgtg gtcgcttatg tacttccaca gaagggatct gcgtttagcc tccatggcca     9900

tatgctcagc agttccaacg gaatggtttc caacaagcag aacaacatgg tcaatccacg     9960

ctcatcacca gtggatgacc actgaagata tgctcaaagt gtggaacaga gtgtggatag    10020

aagacaaccc taatatgact gacaagactc cagtccattc gtgggaagat ataccttacc    10080

tagggaaaag agaggatttg tggtgtggat ccctgattgg actttcttcc agagccacct    10140

gggcgaagaa cattcatacg gccataaccc aggtcaggaa cctgatcgga aaagaggaat    10200

acgtggatta catgccagta atgaaaagat acagtgctcc ttcagagagt gaaggagttc    10260

tgtaattacc aacaacaaac accaaaggct attgaagtca ggccacttgt gccacggttt    10320

gagcaaaccg tgctgcctgt agctccgcca ataatgggag gcgtaataat ccccagggag    10380

gccatgcgcc acggaagctg tacgcgtggc atattggact agcggttaga ggagacccct    10440

cccatcactg ataaaacgca gcaaaagggg gcccgaagcc aggaggaagc tgtactcctg    10500

gtggaaggac tagaggttag aggagacccc cccaacacaa aaacagcata ttgacgctgg    10560

gaaagaccag agatcctgct gtctctgcaa catcaatcca ggcacagagc gccgcaagat    10620

ggattggtgt tgttgatcca acaggttct                                      10649


<210>  9
<211>  3423
<212>  PRT
<213>  Zika virus

<400>  9

Met Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Ser Pro Phe Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Lys Lys Arg Arg Gly Ala Asp Thr Ser Val Gly Ile 
            100                 105                 110         


Val Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Val Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Asn Asp Ala Gly Glu Ala 
    130                 135                 140                 


Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys Tyr Ile Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Thr Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His 
        435                 440                 445             


Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro 
    450                 455                 460                 


Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 
465                 470                 475                 480 


Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     


Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro 
            500                 505                 510         


Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 
        515                 520                 525             


Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 
    530                 535                 540                 


Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala 
545                 550                 555                 560 


Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser 
                565                 570                 575     


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         


Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro 
        595                 600                 605             


Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly 
    610                 615                 620                 


Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln 
625                 630                 635                 640 


Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 
                645                 650                 655     


Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 
            660                 665                 670         


Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His 
        675                 680                 685             


His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr 
    690                 695                 700                 


Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 


Phe Gly Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His 
                725                 730                 735     


Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         


Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn 
        755                 760                 765             


Ala Lys Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val 
    770                 775                 780                 


Leu Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val 
785                 790                 795                 800 


Asp Phe Ser Lys Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Val Tyr 
                805                 810                 815     


Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser 
            820                 825                 830         


Pro Arg Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Glu Asp Gly Ile 
        835                 840                 845             


Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Arg Ser 
    850                 855                 860                 


Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu 
865                 870                 875                 880 


Thr Val Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln 
                885                 890                 895     


Arg Leu Pro Val Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp 
            900                 905                 910         


Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val 
        915                 920                 925             


Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Lys His Arg Ala Trp 
    930                 935                 940                 


Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser 
945                 950                 955                 960 


Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala 
                965                 970                 975     


Val Ile Gly Thr Ala Val Lys Gly Lys Glu Ala Val His Ser Asp Leu 
            980                 985                 990         


Gly Tyr Trp Ile Glu Ser Glu Lys  Asn Asp Thr Trp Arg  Leu Lys Arg 
        995                 1000                 1005             


Ala His  Leu Ile Glu Met Lys  Thr Cys Glu Trp Pro  Lys Ser His 
    1010                 1015                 1020             


Thr Leu  Trp Thr Asp Gly Ile  Glu Glu Ser Asp Leu  Ile Ile Pro 
    1025                 1030                 1035             


Lys Ser  Leu Ala Gly Pro Leu  Ser His His Asn Thr  Arg Glu Gly 
    1040                 1045                 1050             


Tyr Arg  Thr Gln Met Lys Gly  Pro Trp His Ser Glu  Glu Leu Glu 
    1055                 1060                 1065             


Ile Arg  Phe Glu Glu Cys Pro  Gly Thr Lys Val His  Val Glu Glu 
    1070                 1075                 1080             


Thr Cys  Gly Thr Arg Gly Pro  Ser Leu Arg Ser Thr  Thr Ala Ser 
    1085                 1090                 1095             


Gly Arg  Val Ile Glu Glu Trp  Cys Cys Arg Glu Cys  Thr Met Pro 
    1100                 1105                 1110             


Pro Leu  Ser Phe Arg Ala Lys  Asp Gly Cys Trp Tyr  Gly Met Glu 
    1115                 1120                 1125             


Ile Arg  Pro Arg Lys Glu Pro  Glu Ser Asn Leu Val  Arg Ser Met 
    1130                 1135                 1140             


Val Thr  Ala Gly Ser Thr Asp  His Met Asp His Phe  Ser Leu Gly 
    1145                 1150                 1155             


Val Leu  Val Ile Leu Leu Met  Val Gln Glu Gly Leu  Lys Lys Arg 
    1160                 1165                 1170             


Met Thr  Thr Lys Ile Ile Ile  Ser Thr Ser Met Ala  Val Leu Val 
    1175                 1180                 1185             


Ala Met  Ile Leu Gly Gly Phe  Ser Met Ser Asp Leu  Ala Lys Leu 
    1190                 1195                 1200             


Ala Ile  Leu Met Gly Ala Thr  Phe Ala Glu Met Asn  Thr Gly Gly 
    1205                 1210                 1215             


Asp Val  Ala His Leu Ala Leu  Ile Ala Ala Phe Lys  Val Arg Pro 
    1220                 1225                 1230             


Ala Leu  Leu Val Ser Phe Ile  Phe Arg Ala Asn Trp  Thr Pro Arg 
    1235                 1240                 1245             


Glu Ser  Met Leu Leu Ala Leu  Ala Ser Cys Leu Leu  Gln Thr Ala 
    1250                 1255                 1260             


Ile Ser  Ala Leu Glu Gly Asp  Leu Met Val Leu Ile  Asn Gly Phe 
    1265                 1270                 1275             


Ala Leu  Ala Trp Leu Ala Ile  Arg Ala Met Val Val  Pro Arg Thr 
    1280                 1285                 1290             


Asp Asn  Ile Thr Leu Ala Ile  Leu Ala Ala Leu Thr  Pro Leu Ala 
    1295                 1300                 1305             


Arg Gly  Thr Leu Leu Val Ala  Trp Arg Ala Gly Leu  Ala Thr Cys 
    1310                 1315                 1320             


Gly Gly  Phe Met Leu Leu Ser  Leu Lys Gly Lys Gly  Ser Val Lys 
    1325                 1330                 1335             


Lys Asn  Leu Pro Phe Val Met  Ala Leu Gly Leu Thr  Ala Val Arg 
    1340                 1345                 1350             


Leu Val  Asp Pro Ile Asn Val  Val Gly Leu Leu Leu  Leu Thr Arg 
    1355                 1360                 1365             


Ser Gly  Lys Arg Ser Trp Pro  Pro Ser Glu Val Leu  Thr Ala Val 
    1370                 1375                 1380             


Gly Leu  Ile Cys Ala Leu Ala  Gly Gly Phe Ala Lys  Ala Asp Ile 
    1385                 1390                 1395             


Glu Met  Ala Gly Pro Met Ala  Ala Val Gly Leu Leu  Ile Val Ser 
    1400                 1405                 1410             


Tyr Val  Val Ser Gly Lys Ser  Val Asp Met Tyr Ile  Glu Arg Ala 
    1415                 1420                 1425             


Gly Asp  Ile Thr Trp Glu Lys  Asp Ala Glu Val Thr  Gly Asn Ser 
    1430                 1435                 1440             


Pro Arg  Leu Asp Val Ala Leu  Asp Glu Ser Gly Asp  Phe Ser Leu 
    1445                 1450                 1455             


Val Glu  Asp Asp Gly Pro Pro  Met Arg Glu Ile Ile  Leu Lys Val 
    1460                 1465                 1470             


Val Leu  Met Thr Ile Cys Gly  Met Asn Pro Ile Ala  Ile Pro Phe 
    1475                 1480                 1485             


Ala Ala  Gly Ala Trp Tyr Val  Tyr Val Lys Thr Gly  Lys Arg Ser 
    1490                 1495                 1500             


Gly Ala  Leu Trp Asp Val Pro  Ala Pro Lys Glu Val  Lys Lys Gly 
    1505                 1510                 1515             


Glu Thr  Thr Asp Gly Val Tyr  Arg Val Met Thr Arg  Arg Leu Leu 
    1520                 1525                 1530             


Gly Ser  Thr Gln Val Gly Val  Gly Val Met Gln Glu  Gly Val Phe 
    1535                 1540                 1545             


His Thr  Met Trp His Val Thr  Lys Gly Ser Ala Leu  Arg Ser Gly 
    1550                 1555                 1560             


Glu Gly  Arg Leu Asp Pro Tyr  Trp Gly Asp Val Lys  Gln Asp Leu 
    1565                 1570                 1575             


Val Ser  Tyr Cys Gly Pro Trp  Lys Leu Asp Ala Ala  Trp Asp Gly 
    1580                 1585                 1590             


His Ser  Glu Val Gln Leu Leu  Ala Val Pro Pro Gly  Glu Arg Ala 
    1595                 1600                 1605             


Arg Asn  Ile Gln Thr Leu Pro  Gly Ile Phe Lys Thr  Lys Asp Gly 
    1610                 1615                 1620             


Asp Ile  Gly Ala Val Ala Leu  Asp Tyr Pro Ala Gly  Thr Ser Gly 
    1625                 1630                 1635             


Ser Pro  Ile Leu Asp Lys Cys  Gly Arg Val Ile Gly  Leu Tyr Gly 
    1640                 1645                 1650             


Asn Gly  Val Val Ile Lys Asn  Gly Ser Tyr Val Ser  Ala Ile Thr 
    1655                 1660                 1665             


Gln Gly  Arg Arg Glu Glu Glu  Thr Pro Val Glu Cys  Phe Glu Pro 
    1670                 1675                 1680             


Ser Met  Leu Lys Lys Lys Gln  Leu Thr Val Leu Asp  Leu His Pro 
    1685                 1690                 1695             


Gly Ala  Gly Lys Thr Arg Arg  Val Leu Pro Glu Ile  Val Arg Glu 
    1700                 1705                 1710             


Ala Ile  Lys Thr Arg Leu Arg  Thr Val Ile Leu Ala  Pro Thr Arg 
    1715                 1720                 1725             


Val Val  Ala Ala Glu Met Glu  Glu Ala Leu Arg Gly  Leu Pro Val 
    1730                 1735                 1740             


Arg Tyr  Met Thr Thr Ala Val  Asn Val Thr His Ser  Gly Thr Glu 
    1745                 1750                 1755             


Ile Val  Asp Leu Met Cys His  Ala Thr Phe Thr Ser  Arg Leu Leu 
    1760                 1765                 1770             


Gln Pro  Ile Arg Val Pro Asn  Tyr Asn Leu Tyr Ile  Met Asp Glu 
    1775                 1780                 1785             


Ala His  Phe Thr Asp Pro Ser  Ser Ile Ala Ala Arg  Gly Tyr Ile 
    1790                 1795                 1800             


Ser Thr  Arg Val Glu Met Gly  Glu Ala Ala Ala Ile  Phe Met Thr 
    1805                 1810                 1815             


Ala Thr  Pro Pro Gly Thr Arg  Asp Ala Phe Pro Asp  Ser Asn Ser 
    1820                 1825                 1830             


Pro Ile  Met Asp Thr Glu Val  Glu Val Pro Glu Arg  Ala Trp Ser 
    1835                 1840                 1845             


Ser Gly  Phe Asp Trp Val Thr  Asp His Ser Gly Lys  Thr Val Trp 
    1850                 1855                 1860             


Phe Val  Pro Ser Val Arg Asn  Gly Asn Glu Ile Ala  Ala Cys Leu 
    1865                 1870                 1875             


Thr Lys  Ala Gly Lys Arg Val  Ile Gln Leu Ser Arg  Lys Thr Phe 
    1880                 1885                 1890             


Glu Thr  Glu Phe Gln Lys Thr  Lys His Gln Glu Trp  Asp Phe Val 
    1895                 1900                 1905             


Val Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Asp 
    1910                 1915                 1920             


Arg Val  Ile Asp Ser Arg Arg  Cys Leu Lys Pro Val  Ile Leu Asp 
    1925                 1930                 1935             


Gly Glu  Arg Val Ile Leu Ala  Gly Pro Met Pro Val  Thr His Ala 
    1940                 1945                 1950             


Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly Arg Asn  Pro Asn Lys 
    1955                 1960                 1965             


Pro Gly  Asp Glu Tyr Leu Tyr  Gly Gly Gly Cys Ala  Glu Thr Asp 
    1970                 1975                 1980             


Glu Asp  His Ala His Trp Leu  Glu Ala Arg Met Leu  Leu Asp Asn 
    1985                 1990                 1995             


Ile Tyr  Leu Gln Asp Gly Leu  Ile Ala Ser Leu Tyr  Arg Pro Glu 
    2000                 2005                 2010             


Ala Asp  Lys Val Ala Ala Ile  Glu Gly Glu Phe Lys  Leu Arg Thr 
    2015                 2020                 2025             


Glu Gln  Arg Lys Thr Phe Val  Glu Leu Met Lys Arg  Gly Asp Leu 
    2030                 2035                 2040             


Pro Val  Trp Leu Ala Tyr Gln  Val Ala Ser Ala Gly  Ile Thr Tyr 
    2045                 2050                 2055             


Thr Asp  Arg Arg Trp Cys Phe  Asp Gly Thr Thr Asn  Asn Thr Ile 
    2060                 2065                 2070             


Met Glu  Asp Ser Val Pro Ala  Glu Val Trp Thr Arg  His Gly Glu 
    2075                 2080                 2085             


Lys Arg  Val Leu Lys Pro Arg  Trp Met Asp Ala Arg  Val Cys Ser 
    2090                 2095                 2100             


Asp His  Ala Ala Leu Lys Ser  Phe Lys Glu Phe Ala  Ala Gly Lys 
    2105                 2110                 2115             


Arg Gly  Ala Ala Phe Gly Val  Met Glu Ala Leu Gly  Thr Leu Pro 
    2120                 2125                 2130             


Gly His  Met Thr Glu Arg Phe  Gln Glu Ala Ile Asp  Asn Leu Ala 
    2135                 2140                 2145             


Val Leu  Met Arg Ala Glu Thr  Gly Ser Arg Pro Tyr  Lys Ala Ala 
    2150                 2155                 2160             


Ala Ala  Gln Leu Pro Glu Thr  Leu Glu Thr Ile Met  Leu Leu Gly 
    2165                 2170                 2175             


Leu Leu  Gly Thr Val Ser Leu  Gly Ile Phe Phe Val  Leu Met Arg 
    2180                 2185                 2190             


Asn Lys  Gly Ile Gly Lys Met  Gly Phe Gly Met Val  Thr Leu Gly 
    2195                 2200                 2205             


Ala Ser  Ala Trp Leu Met Trp  Leu Ser Glu Ile Glu  Pro Ala Arg 
    2210                 2215                 2220             


Ile Ala  Cys Val Leu Ile Val  Val Phe Leu Leu Leu  Val Val Leu 
    2225                 2230                 2235             


Ile Pro  Glu Pro Glu Lys Gln  Arg Ser Pro Gln Asp  Asn Gln Met 
    2240                 2245                 2250             


Ala Ile  Ile Ile Met Val Ala  Val Gly Leu Leu Gly  Leu Ile Thr 
    2255                 2260                 2265             


Ala Asn  Glu Leu Gly Trp Leu  Glu Arg Thr Lys Ser  Asp Leu Ser 
    2270                 2275                 2280             


His Leu  Met Gly Arg Arg Glu  Glu Gly Ala Thr Ile  Gly Phe Ser 
    2285                 2290                 2295             


Met Asp  Ile Asp Leu Arg Pro  Ala Ser Ala Trp Ala  Ile Tyr Ala 
    2300                 2305                 2310             


Ala Leu  Thr Thr Phe Ile Thr  Pro Ala Val Gln His  Ala Val Thr 
    2315                 2320                 2325             


Thr Ser  Tyr Asn Asn Tyr Ser  Leu Met Ala Met Ala  Thr Gln Ala 
    2330                 2335                 2340             


Gly Val  Leu Phe Gly Met Gly  Lys Gly Met Pro Phe  Tyr Ala Trp 
    2345                 2350                 2355             


Asp Phe  Gly Val Pro Leu Leu  Met Ile Gly Cys Tyr  Ser Gln Leu 
    2360                 2365                 2370             


Thr Pro  Leu Thr Leu Ile Val  Ala Ile Ile Leu Leu  Val Ala His 
    2375                 2380                 2385             


Tyr Met  Tyr Leu Ile Pro Gly  Leu Gln Ala Ala Ala  Ala Arg Ala 
    2390                 2395                 2400             


Ala Gln  Lys Arg Thr Ala Ala  Gly Ile Met Lys Asn  Pro Val Val 
    2405                 2410                 2415             


Asp Gly  Ile Val Val Thr Asp  Ile Asp Thr Met Thr  Ile Asp Pro 
    2420                 2425                 2430             


Gln Val  Glu Lys Lys Met Gly  Gln Val Leu Leu Ile  Ala Val Ala 
    2435                 2440                 2445             


Val Ser  Ser Ala Ile Leu Ser  Arg Thr Ala Trp Gly  Trp Gly Glu 
    2450                 2455                 2460             


Ala Gly  Ala Leu Ile Thr Ala  Ala Thr Ser Thr Leu  Trp Glu Gly 
    2465                 2470                 2475             


Ser Pro  Asn Lys Tyr Trp Asn  Ser Ser Thr Ala Thr  Ser Leu Cys 
    2480                 2485                 2490             


Asn Ile  Phe Arg Gly Ser Tyr  Leu Ala Gly Ala Ser  Leu Ile Tyr 
    2495                 2500                 2505             


Thr Val  Thr Arg Asn Ala Gly  Leu Val Lys Arg Arg  Gly Gly Gly 
    2510                 2515                 2520             


Thr Gly  Glu Thr Leu Gly Glu  Lys Trp Lys Ala Arg  Leu Asn Gln 
    2525                 2530                 2535             


Met Ser  Ala Leu Glu Phe Tyr  Ser Tyr Lys Lys Ser  Gly Ile Thr 
    2540                 2545                 2550             


Glu Val  Cys Arg Glu Glu Ala  Arg Arg Ala Leu Lys  Asp Gly Val 
    2555                 2560                 2565             


Ala Thr  Gly Gly His Ala Val  Ser Arg Gly Ser Ala  Lys Leu Arg 
    2570                 2575                 2580             


Trp Leu  Val Glu Arg Gly Tyr  Leu Gln Pro Tyr Gly  Lys Val Ile 
    2585                 2590                 2595             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Ser Tyr Tyr  Ala Ala Thr 
    2600                 2605                 2610             


Ile Arg  Lys Val Gln Glu Val  Lys Gly Tyr Thr Lys  Gly Gly Pro 
    2615                 2620                 2625             


Gly His  Glu Glu Pro Val Leu  Val Gln Ser Tyr Gly  Trp Asn Ile 
    2630                 2635                 2640             


Val Arg  Leu Lys Ser Gly Val  Asp Val Phe His Met  Ala Ala Glu 
    2645                 2650                 2655             


Pro Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Ser Ser 
    2660                 2665                 2670             


Pro Glu  Val Glu Glu Ala Arg  Thr Leu Arg Val Leu  Ser Met Val 
    2675                 2680                 2685             


Gly Asp  Trp Leu Glu Lys Arg  Pro Gly Ala Phe Cys  Ile Lys Val 
    2690                 2695                 2700             


Leu Cys  Pro Tyr Thr Ser Thr  Met Met Glu Thr Leu  Glu Arg Leu 
    2705                 2710                 2715             


Gln Arg  Arg Tyr Gly Gly Gly  Leu Val Arg Val Pro  Leu Ser Arg 
    2720                 2725                 2730             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Gly Ala  Lys Ser Asn 
    2735                 2740                 2745             


Thr Ile  Lys Ser Val Ser Thr  Thr Ser Gln Leu Leu  Leu Gly Arg 
    2750                 2755                 2760             


Met Asp  Gly Pro Arg Arg Pro  Val Lys Tyr Glu Glu  Asp Val Asn 
    2765                 2770                 2775             


Leu Gly  Ser Gly Thr Arg Ala  Val Val Ser Cys Ala  Glu Ala Pro 
    2780                 2785                 2790             


Asn Met  Lys Ile Ile Gly Asn  Arg Ile Glu Arg Ile  Arg Ser Glu 
    2795                 2800                 2805             


His Ala  Glu Thr Trp Phe Phe  Asp Glu Asn His Pro  Tyr Arg Thr 
    2810                 2815                 2820             


Trp Ala  Tyr His Gly Ser Tyr  Glu Ala Pro Thr Gln  Gly Ser Ala 
    2825                 2830                 2835             


Ser Ser  Leu Ile Asn Gly Val  Val Arg Leu Leu Ser  Lys Pro Trp 
    2840                 2845                 2850             


Asp Val  Val Thr Gly Val Thr  Gly Ile Ala Met Thr  Asp Thr Thr 
    2855                 2860                 2865             


Pro Tyr  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2870                 2875                 2880             


Val Pro  Asp Pro Gln Glu Gly  Thr Arg Gln Val Met  Ser Met Val 
    2885                 2890                 2895             


Ser Ser  Trp Leu Trp Lys Glu  Leu Gly Lys His Lys  Arg Pro Arg 
    2900                 2905                 2910             


Val Cys  Thr Lys Glu Glu Phe  Ile Asn Lys Val Arg  Ser Asn Ala 
    2915                 2920                 2925             


Ala Leu  Gly Ala Ile Phe Glu  Glu Glu Lys Glu Trp  Lys Thr Ala 
    2930                 2935                 2940             


Val Glu  Ala Val Asn Asp Pro  Arg Phe Trp Ala Leu  Val Asp Lys 
    2945                 2950                 2955             


Glu Arg  Glu His His Leu Arg  Gly Glu Cys Gln Ser  Cys Val Tyr 
    2960                 2965                 2970             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Gln Gly Glu  Phe Gly Lys 
    2975                 2980                 2985             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2990                 2995                 3000             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    3005                 3010                 3015             


Met Gly  Arg Glu Asn Ser Gly  Gly Gly Val Glu Gly  Leu Gly Leu 
    3020                 3025                 3030             


Gln Arg  Leu Gly Tyr Val Leu  Glu Glu Met Ser Arg  Ile Pro Gly 
    3035                 3040                 3045             


Gly Arg  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3050                 3055                 3060             


Ser Arg  Phe Asp Leu Glu Asn  Glu Ala Leu Ile Thr  Asn Gln Met 
    3065                 3070                 3075             


Glu Lys  Gly His Arg Ala Leu  Ala Leu Ala Ile Ile  Lys Tyr Thr 
    3080                 3085                 3090             


Tyr Gln  Asn Lys Val Val Lys  Val Leu Arg Pro Ala  Glu Lys Gly 
    3095                 3100                 3105             


Lys Thr  Val Met Asp Ile Ile  Ser Arg Gln Asp Gln  Arg Gly Ser 
    3110                 3115                 3120             


Gly Gln  Val Val Thr Tyr Ala  Leu Asn Thr Phe Thr  Asn Leu Val 
    3125                 3130                 3135             


Val Gln  Leu Ile Arg Asn Met  Glu Ala Glu Glu Val  Leu Glu Met 
    3140                 3145                 3150             


Gln Asp  Leu Trp Leu Leu Arg  Arg Ser Glu Lys Val  Thr Asn Trp 
    3155                 3160                 3165             


Leu Gln  Ser Asn Gly Trp Asp  Arg Leu Lys Arg Met  Ala Val Ser 
    3170                 3175                 3180             


Gly Asp  Asp Cys Val Val Lys  Pro Ile Asp Asp Arg  Phe Ala His 
    3185                 3190                 3195             


Ala Leu  Arg Phe Leu Asn Asp  Met Gly Lys Val Arg  Lys Asp Thr 
    3200                 3205                 3210             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Asp Asn Trp  Glu Glu Val 
    3215                 3220                 3225             


Pro Phe  Cys Ser His His Phe  Asn Lys Leu His Leu  Lys Asp Gly 
    3230                 3235                 3240             


Arg Ser  Ile Val Val Pro Cys  Arg His Gln Asp Glu  Leu Ile Gly 
    3245                 3250                 3255             


Arg Ala  Arg Val Ser Pro Gly  Ala Gly Trp Ser Ile  Arg Glu Thr 
    3260                 3265                 3270             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Gln  Leu Leu Tyr 
    3275                 3280                 3285             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3290                 3295                 3300             


Ser Val  Pro Val Asp Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3305                 3310                 3315             


Ile His  Gly Lys Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Val 
    3320                 3325                 3330             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Asp His  Met Glu Asp 
    3335                 3340                 3345             


Lys Thr  Pro Val Thr Lys Trp  Thr Asp Ile Pro Tyr  Leu Gly Lys 
    3350                 3355                 3360             


Arg Glu  Asp Leu Trp Cys Gly  Ser Leu Ile Gly His  Arg Pro Arg 
    3365                 3370                 3375             


Thr Thr  Trp Ala Glu Asn Ile  Lys Asn Thr Val Asn  Met Val Arg 
    3380                 3385                 3390             


Arg Ile  Ile Gly Asp Glu Glu  Lys Tyr Met Asp Tyr  Leu Ser Thr 
    3395                 3400                 3405             


Gln Val  Arg Tyr Leu Gly Glu  Glu Gly Ser Thr Pro  Gly Val Leu 
    3410                 3415                 3420             


<210>  10
<211>  10374
<212>  DNA
<213>  Zika virus

<400>  10
acaggtttta ttttggattt ggaaacgaga gtttctggtc atgaaaaacc caaaaaagaa       60

atccggagga ttccggattg tcaatatgct aaaacgcgga gtagcccgtg tgagcccctt      120

tgggggcttg aagaggctgc cagccggact tctgctgggt catgggccca tcaggatggt      180

cttggcgatt ctagcctttt tgagattcac ggcaatcaag ccatcactgg gtctcatcaa      240

tagatggggt tcagtgggga aaaaagaggc tatggaaata ataaagaagt tcaagaaaga      300

tctggctgcc atgctgagaa taatcaatgc taggaaggag aagaagagac gaggcgcaga      360

tactagtgtc ggaattgttg gcctcctgct gaccacagct atggcagcgg aggtcactag      420

acgtgggagt gcatactata tgtacttgga cagaaacgat gctggggagg ccatatcttt      480

tccaaccaca ttggggatga ataagtgtta tatacagatc atggatcttg gacacacgtg      540

tgatgccacc atgagctatg aatgccctat gctggatgag ggggtggaac cagatgacgt      600

cgattgttgg tgcaacacga cgtcaacttg ggttgtgtac ggaacctgcc atcacaaaaa      660

aggtgaagca cggagatcta gaagagctgt gacgctcccc tcccattcca ctaggaagct      720

gcaaacgcgg tcgcaaacct ggttggaatc aagagaatac acaaagcact tgattagagt      780

cgaaaattgg atattcagga accctggctt cgcgttagca gcagctgcca tcgcttggct      840

tttgggaagc tcaacgagcc aaaaagtcat atacttggtc atgatactgc tgattgcccc      900

ggcatacagc atcaggtgca taggagtcag caatagggac tttgtggaag gtatgtcagg      960

tgggacttgg gttgatgttg tcttggaaca tggaggttgt gtcactgtaa tggcacagga     1020

caaaccgact gtcgacatag agctggttac aacaacagtc agcaacatgg cggaggtaag     1080

atcctactgc tatgaggcat caatatcaga catggcttcg gacagccgct gcccaacaca     1140

aggtgaagcc taccttgaca agcaatcaga cactcaatat gtctgcaaaa gaacgttagt     1200

ggacagaggc tggggaaatg gatgtggact ttttggcaaa gggagcctgg tgacatgcgc     1260

taagtttgca tgctccaaga aaatgaccgg gaagagcatc cagccagaga atctggagta     1320

ccggataatg ctgtcagttc atggctccca gcacagtggg atgatcgtta atgacacagg     1380

acatgaaact gatgagaata gagcgaaagt tgagataacg cccaattcac caagagccga     1440

agccaccctg ggggggtttg gaagcctagg acttgattgt gaaccgagga caggccttga     1500

cttttcagat ttgtattact tgactatgaa taacaagcac tggctggttc acaaggagtg     1560

gttccacgac attccattac cttggcacgc tggggcagac accggaactc cacactggaa     1620

caacaaagaa gcactggtag agttcaagga cgcacatgcc aaaaggcaaa ctgtcgtggt     1680

tctagggagt caagaaggag cagttcacac ggcccttgct ggagctctgg aggctgagat     1740

ggatggtgca aagggaaggc tgtcctctgg ccacttgaaa tgtcgcctga aaatggataa     1800

acttagattg aagggcgtgt catactcctt gtgtactgca gcgttcacat tcaccaagat     1860

cccggctgaa acactgcacg ggacagtcac agtggaggta cagtacgcag ggacagatgg     1920

accttgcaag gttccagctc agatggcggt ggacatgcaa actctgaccc cagttgggag     1980

gttgataacc gctaaccccg taatcactga aagcactgag aactctaaga tgatgctgga     2040

acttgatcca ccatttgggg actcttacat tgtcatagga gtcggggaga agaagatcac     2100

ccaccactgg cacaggagtg gcagcaccat tggaaaagca tttgaagcca ctgtgagagg     2160

tgccaagaga atggcagtct tgggagacac agcctgggac tttggatcag ttggaggcgc     2220

tctcaactca ttgggcaagg gcatccatca aatctttgga gcagctttca aatcattgtt     2280

tggaggaatg tcctggttct cacaaattct cattggaacg ttgctgatgt ggttgggtct     2340

gaacgcaaag aatggatcta tttcccttat gtgcttggcc ttagggggag tgttgatctt     2400

cttatccaca gccgtctctg ctgatgtggg gtgctcggtg gacttctcaa agaaggagac     2460

gagatgcggt acaggggtgt tcgtctataa cgacgttgaa gcctggaggg acaggtacaa     2520

gtaccatcct gactcccccc gtagattggc agcagcagtc aagcaagcct gggaagatgg     2580

tatctgcggg atctcctctg tttcaagaat ggaaaacatc atgtggagat cagtagaagg     2640

ggagctcaac gcaatcctgg aagagaatgg agttcaactg acggtcgttg tgggatctgt     2700

aaaaaacccc atgtggagag gtccacagag attgcccgtg cctgtgaacg agctgcccca     2760

cggctggaag gcttggggga aatcgtactt cgtcagagca gcaaagacaa ataacagctt     2820

tgtcgtggat ggtgacacac tgaaggaatg cccactcaaa catagagcat ggaacagctt     2880

tcttgtggag gatcatgggt tcggggtatt tcacactagt gtctggctca aggttagaga     2940

agattattca ttagagtgtg atccagccgt tattggaaca gctgttaagg gaaaggaggc     3000

tgtacacagt gatctaggct actggattga gagtgagaag aatgacacat ggaggctgaa     3060

gagggcccat ctgatcgaga tgaaaacatg tgaatggcca aagtcccaca cattgtggac     3120

agatggaata gaagagagtg atctgatcat acccaagtct ttagctgggc cactcagcca     3180

tcacaatacc agagagggct acaggaccca aatgaaaggg ccatggcaca gtgaagagct     3240

tgaaattcgg tttgaggaat gcccaggcac taaggtccac gtggaggaaa catgtggaac     3300

gagaggacca tctctgagat caaccactgc aagcggaagg gtgatcgagg aatggtgctg     3360

cagggagtgc acaatgcccc cactgtcgtt ccgggctaaa gatggctgtt ggtatggaat     3420

ggagataagg cccaggaaag aaccagaaag caacttagta aggtcaatgg tgactgcagg     3480

atcaactgat cacatggacc acttctccct tggagtgctt gtgattctgc tcatggtgca     3540

ggaagggttg aagaagagaa tgaccacaaa gatcatcata agcacatcaa tggcagtgct     3600

ggtagctatg atcctgggag gattttcaat gagtgacctg gctaagcttg caattttgat     3660

gggtgccacc ttcgcggaaa tgaacactgg aggagatgta gctcatctgg cgctgatagc     3720

ggcattcaaa gtcagaccag cgttgctggt atctttcatc ttcagagcta attggacacc     3780

ccgtgaaagc atgctgctgg ccttggcctc gtgtcttttg caaactgcga tctccgcctt     3840

ggaaggcgac ctgatggttc tcatcaatgg ttttgctttg gcctggttgg caatacgagc     3900

gatggttgtt ccacgcactg ataacatcac cttggcaatc ctggctgctc tgacaccact     3960

ggcccggggc acactgcttg tggcgtggag agcaggcctt gctacttgcg gggggtttat     4020

gctcctctct ctgaagggaa aaggcagtgt gaagaagaac ttaccatttg tcatggccct     4080

gggactaacc gctgtgaggc tggtcgaccc catcaacgtg gtgggactgc tgttgctcac     4140

aaggagtggg aagcggagct ggccccctag cgaagtactc acagctgttg gcctgatatg     4200

cgcattggct ggagggttcg ccaaggcaga tatagagatg gctgggccca tggccgcggt     4260

cggtctgcta attgtcagtt acgtggtctc aggaaagagt gtggacatgt acattgaaag     4320

agcaggtgac atcacatggg aaaaagatgc ggaagtcact ggaaacagtc cccggctcga     4380

tgtggcgcta gatgagagtg gtgatttctc cctggtggag gatgacggtc cccccatgag     4440

agagatcata ctcaaggtgg tcctgatgac catctgtggc atgaacccaa tagccatacc     4500

ctttgcagct ggagcgtggt acgtatacgt gaagactgga aaaaggagtg gtgctctatg     4560

ggatgtgcct gctcccaagg aagtaaaaaa gggggagacc acagatggag tgtacagagt     4620

aatgactcgt agactgctag gttcaacaca agttggagtg ggagttatgc aagagggggt     4680

ctttcacact atgtggcacg tcacaaaagg atccgcgctg agaagcggtg aagggagact     4740

tgatccatac tggggagatg tcaagcagga tctggtgtca tactgtggtc catggaagct     4800

agatgccgcc tgggacgggc acagcgaggt gcagctcttg gccgtgcccc ccggagagag     4860

agcgaggaac atccagactc tgcccggaat atttaagaca aaggatgggg acattggagc     4920

ggttgcgctg gattacccag caggaacttc aggatctcct atcctagaca agtgtgggag     4980

agtgatagga ctttatggca atggggtcgt gatcaaaaat gggagttatg ttagtgccat     5040

cacccaaggg aggagggagg aagagactcc tgttgagtgc ttcgagcctt cgatgctgaa     5100

gaagaagcag ctaactgtct tagacttgca tcctggagct gggaaaacca ggagagttct     5160

tcctgaaata gtccgtgaag ccataaaaac aagactccgt actgtgatct tagctccaac     5220

cagggttgtc gctgctgaaa tggaggaggc ccttagaggg cttccagtgc gttatatgac     5280

aacagcagtc aatgtcaccc actctggaac agaaatcgtc gacttaatgt gccatgccac     5340

cttcacttcg cgtctactac agccaatcag agtccccaac tataatctgt atattatgga     5400

tgaggcccac ttcacagatc cctcaagtat agcagcaaga ggatacattt caacaagggt     5460

tgagatgggc gaggcggccg ccatcttcat gaccgccacg ccaccaggaa cccgtgacgc     5520

atttccggac tccaactcac caattatgga caccgaagtg gaagtcccag agagagcctg     5580

gagctcaggc tttgattggg tgacggatca ttctggaaaa acagtttggt ttgttccaag     5640

cgtgaggaac ggcaatgaga tcgcagcttg tctgacaaag gctggaaaac gggtcataca     5700

gctcagcaga aagacttttg agacagagtt ccagaaaaca aaacatcaag agtgggactt     5760

tgtcgtgaca actgacattt cagagatggg cgccaacttt aaagctgacc gtgtcataga     5820

ttccaggaga tgcctaaagc cggtcatact tgatggcgag agagtcattc tggctggacc     5880

catgcctgtc acacatgcca gcgctgccca gaggaggggg cgcataggca ggaatcccaa     5940

caaacctgga gatgagtatc tgtatggagg tgggtgcgca gagactgacg aagaccatgc     6000

acactggctt gaagcaagaa tgctccttga caatatttac ctccaagatg gcctcatagc     6060

ctcgctctat cgacctgagg ccgacaaagt agcagccatt gagggagagt tcaagcttag     6120

gacggagcaa aggaagacct ttgtggaact catgaaaaga ggagatcttc ctgtttggct     6180

ggcctatcag gttgcatctg ccggaataac ctacacagat agaagatggt gctttgatgg     6240

cacgaccaac aacaccataa tggaagacag tgtgccggca gaagtgtgga ccagacacgg     6300

agagaaaaga gtgctcaaac cgaggtggat ggacgccaga gtttgttcag atcatgcggc     6360

cctgaagtca ttcaaggagt ttgccgctgg gaaaagagga gcggcttttg gagtgatgga     6420

agccctggga acactgccag gacacatgac agagagattc caggaagcca ttgacaacct     6480

cgctgtgctc atgcgggcag agactggaag caggccttac aaagccgcgg cggcccaatt     6540

gccggagacc ctagagacca ttatgctttt ggggttgctg ggaacagtct cgctgggaat     6600

cttcttcgtc ttgatgagga acaagggcat agggaagatg ggctttggaa tggtgactct     6660

tggggccagc gcatggctca tgtggctctc ggaaattgag ccagccagaa ttgcatgtgt     6720

cctcattgtt gtgttcctat tgctggtggt gctcatacct gagccagaaa agcaaagatc     6780

tccccaggac aaccaaatgg caatcatcat catggtagca gtaggtcttc tgggcttgat     6840

taccgccaat gaactcggat ggttggagag aacaaagagt gacctaagcc atctaatggg     6900

aaggagagag gagggggcaa ccataggatt ctcaatggac attgacctgc ggccagcctc     6960

agcttgggcc atctatgctg ccttgacaac tttcattacc ccagccgtcc aacatgcagt     7020

gaccacctca tacaacaact actccttaat ggcgatggcc acgcaagctg gagtgttgtt     7080

tggtatgggc aaagggatgc cattctacgc atgggacttt ggagtcccgc tgctaatgat     7140

aggttgctac tcacaattaa cacccctgac cctaatagtg gccatcattt tgctcgtggc     7200

gcactacatg tacttgatcc cagggctgca ggcagcagct gcgcgtgctg cccagaagag     7260

aacggcagct ggcatcatga agaaccctgt tgtggatgga atagtggtga ctgacattga     7320

cacaatgaca attgaccccc aagtggagaa aaagatggga caggtgctac tcatagcagt     7380

agccgtctcc agcgccatac tgtcgcggac cgcctggggg tggggggagg ctggggccct     7440

gatcacagcc gcaacttcca ctttgtggga aggctctccg aacaagtact ggaactcctc     7500

tacagccact tcactgtgta acatttttag gggaagttac ttggctggag cttctctaat     7560

ctacacagta acaagaaacg ctggcttggt caagagacgt gggggtggaa caggagagac     7620

cctgggagag aaatggaagg cccgcttgaa ccagatgtcg gccctggagt tctactccta     7680

caaaaagtca ggcatcaccg aggtgtgcag agaagaggcc cgccgcgccc tcaaggacgg     7740

tgtggcaacg ggaggccatg ctgtgtcccg aggaagtgca aagctgagat ggttggtgga     7800

gcggggatac ctgcagccct atggaaaggt cattgatctt ggatgtggca gagggggctg     7860

gagttactac gccgccacca tccgcaaagt tcaagaagtg aaaggataca caaaaggagg     7920

ccctggtcat gaagaacccg tgttggtgca aagctatggg tggaacatag tccgtcttaa     7980

gagtggggtg gacgtctttc atatggcggc tgagccgtgt gacacgttgc tgtgtgacat     8040

aggtgagtca tcatctagtc ctgaagtgga agaagcacgg acgctcagag tcctctccat     8100

ggtgggggat tggcttgaaa aaagaccagg agccttttgt ataaaagtgt tgtgcccata     8160

caccagcact atgatggaaa ccctggagcg actgcagcgt aggtatgggg gaggactggt     8220

cagagtgcca ctctcccgca actctacaca tgagatgtac tgggtctctg gagcgaaaag     8280

caacaccata aaaagtgtgt ccaccacgag ccagctcctc ttggggcgca tggacgggcc     8340

taggaggcca gtgaaatatg aggaggatgt gaatctcggc tctggcacgc gggctgtggt     8400

aagctgcgct gaagctccca acatgaagat cattggtaac cgcattgaaa ggatccgcag     8460

tgagcacgcg gaaacgtggt tctttgacga gaaccaccca tataggacat gggcttacca     8520

tggaagctat gaggccccca cacaagggtc agcgtcctct ctaataaacg gggttgtcag     8580

gctcctgtca aaaccctggg atgtggtgac tggagtcaca ggaatagcca tgaccgacac     8640

cacaccgtat ggtcagcaaa gagttttcaa ggaaaaagtg gacactaggg tgccagaccc     8700

ccaagaaggc actcgtcagg ttatgagcat ggtctcttcc tggttgtgga aagagctagg     8760

caaacacaaa cggccacgag tctgtaccaa agaagagttc atcaacaagg ttcgtagcaa     8820

tgcagcatta ggggcaatat ttgaagagga aaaagagtgg aagactgcag tggaagctgt     8880

gaacgatcca aggttctggg ctctagtgga caaggaaaga gagcaccacc tgagaggaga     8940

gtgccagagt tgtgtgtaca acatgatggg aaaaagagaa aagaaacaag gggaatttgg     9000

aaaggccaag ggcagccgcg ccatctggta tatgtggcta ggggctagat ttctagagtt     9060

cgaagccctt ggattcttga acgaggatca ctggatgggg agagagaact caggaggtgg     9120

tgttgaaggg ctgggattac aaagactcgg atatgtccta gaagagatga gtcgtatacc     9180

aggaggaagg atgtatgcag atgacactgc tggctgggac acccgcatta gcaggtttga     9240

tctggagaat gaagctctaa tcaccaacca aatggagaaa gggcacaggg ccttggcatt     9300

ggccataatc aagtacacat accaaaacaa agtggtaaag gtccttagac cagctgaaaa     9360

agggaaaaca gttatggaca ttatttcgag acaagaccaa agggggagcg gacaagttgt     9420

cacttacgct cttaacacat ttaccaacct agtggtgcaa ctcattcgga atatggaggc     9480

tgaggaagtt ctagagatgc aagacttgtg gctgctgcgg aggtcagaga aagtgactaa     9540

ctggttgcag agcaacggat gggataggct caaacgaatg gcagtcagtg gagatgattg     9600

cgttgtgaag ccaattgatg ataggtttgc acatgccctc aggttcttga atgatatggg     9660

aaaagttagg aaggacacac aagagtggaa accctcaact ggatgggaca actgggaaga     9720

agttccgttt tgctcccacc acttcaacaa gctccatctc aaggacggga ggtccattgt     9780

ggttccctgc cgccaccaag atgaactgat tggccgggcc cgcgtctctc caggggcggg     9840

atggagcatc cgggagactg cttgcctagc aaaatcatat gcgcaaatgt ggcagctcct     9900

ttatttccac agaagggacc tccgactgat ggccaatgcc atttgttcat ctgtgccagt     9960

tgactgggtt ccaactggga gaactacctg gtcaatccat ggaaagggag aatggatgac    10020

cactgaagac atgcttgtgg tgtggaacag agtgtggatt gaggagaacg accacatgga    10080

agacaagacc ccagttacga aatggacaga cattccctat ttgggaaaaa gggaagactt    10140

gtggtgtgga tctctcatag ggcacagacc gcgcaccacc tgggctgaga acattaaaaa    10200

cacagtcaac atggtgcgca ggatcatagg tgatgaagaa aagtacatgg actacctatc    10260

cacccaagtt cgctacttgg gtgaagaagg gtctacacct ggagtgctgt aagcaccaat    10320

cttaatgttg tcaggcctgc tagtcagcca cagcttgggg aaagctgtgc agcc          10374


<210>  11
<211>  3392
<212>  PRT
<213>  Dengue virus serotype 1

<400>  11

Met Asn Asn Gln Arg Lys Lys Thr Gly Arg Pro Ser Phe Asn Met Leu 
1               5                   10                  15      


Lys Arg Ala Arg Asn Arg Val Ser Thr Val Ser Gln Leu Ala Lys Arg 
            20                  25                  30          


Phe Ser Lys Gly Leu Leu Ser Gly Gln Gly Pro Met Lys Leu Val Met 
        35                  40                  45              


Ala Phe Ile Ala Phe Leu Arg Phe Leu Ala Ile Pro Pro Thr Ala Gly 
    50                  55                  60                  


Ile Leu Ala Arg Trp Gly Ser Phe Lys Lys Asn Gly Ala Ile Lys Val 
65                  70                  75                  80  


Leu Arg Gly Phe Lys Lys Glu Ile Ser Asn Met Leu Asn Ile Met Asn 
                85                  90                  95      


Arg Arg Lys Arg Ser Val Thr Met Leu Leu Met Leu Leu Pro Thr Ala 
            100                 105                 110         


Leu Ala Phe His Leu Thr Thr Arg Gly Gly Glu Pro His Met Ile Val 
        115                 120                 125             


Ser Lys Gln Glu Arg Gly Lys Ser Leu Leu Phe Lys Thr Ser Ala Gly 
    130                 135                 140                 


Val Asn Met Cys Thr Leu Ile Ala Met Asp Leu Gly Glu Leu Cys Glu 
145                 150                 155                 160 


Asp Thr Met Thr Tyr Lys Cys Pro Arg Ile Thr Glu Thr Glu Pro Asp 
                165                 170                 175     


Asp Val Asp Cys Trp Cys Asn Ala Thr Glu Thr Trp Val Thr Tyr Gly 
            180                 185                 190         


Thr Cys Ser Gln Thr Gly Glu His Arg Arg Asp Lys Arg Ser Val Ala 
        195                 200                 205             


Leu Ala Pro His Val Gly Leu Gly Leu Glu Thr Arg Thr Glu Thr Trp 
    210                 215                 220                 


Met Ser Ser Glu Gly Ala Trp Lys Gln Ile Gln Lys Val Glu Thr Trp 
225                 230                 235                 240 


Val Leu Arg His Pro Gly Phe Thr Val Ile Ala Leu Phe Leu Ala His 
                245                 250                 255     


Ala Ile Gly Thr Ser Ile Thr Gln Lys Gly Ile Ile Phe Ile Leu Leu 
            260                 265                 270         


Met Leu Val Thr Pro Ser Met Ala Met Arg Cys Val Gly Ile Gly Asn 
        275                 280                 285             


Arg Asp Phe Val Glu Gly Leu Ser Gly Ala Thr Trp Val Asp Val Val 
    290                 295                 300                 


Leu Glu His Gly Ser Cys Val Thr Thr Met Ala Lys Asp Lys Pro Thr 
305                 310                 315                 320 


Leu Asp Ile Glu Leu Leu Lys Thr Glu Val Thr Asn Pro Ala Val Leu 
                325                 330                 335     


Arg Lys Leu Cys Ile Glu Ala Lys Ile Ser Asn Thr Thr Thr Asp Ser 
            340                 345                 350         


Arg Cys Pro Thr Gln Gly Glu Ala Thr Leu Val Glu Glu Gln Asp Thr 
        355                 360                 365             


Asn Phe Val Cys Arg Arg Thr Phe Val Asp Arg Gly Trp Gly Asn Gly 
    370                 375                 380                 


Cys Gly Leu Phe Gly Lys Gly Ser Leu Ile Thr Cys Ala Lys Phe Lys 
385                 390                 395                 400 


Cys Val Thr Lys Leu Glu Gly Lys Ile Val Gln Tyr Glu Asn Leu Lys 
                405                 410                 415     


Tyr Ser Val Ile Val Thr Val His Thr Gly Asp Gln His Gln Val Gly 
            420                 425                 430         


Asn Glu Thr Thr Glu His Gly Thr Thr Ala Thr Ile Thr Pro Gln Ala 
        435                 440                 445             


Pro Thr Ser Glu Ile Gln Leu Thr Asp Tyr Gly Ala Leu Thr Leu Asp 
    450                 455                 460                 


Cys Ser Pro Arg Thr Gly Leu Asp Phe Asn Glu Met Val Leu Leu Thr 
465                 470                 475                 480 


Met Glu Lys Lys Ser Trp Leu Val His Lys Gln Trp Phe Leu Asp Leu 
                485                 490                 495     


Pro Leu Pro Trp Thr Ser Gly Ala Ser Thr Ser Gln Glu Thr Trp Asn 
            500                 505                 510         


Arg Gln Asp Leu Leu Val Thr Phe Lys Thr Ala His Ala Lys Lys Gln 
        515                 520                 525             


Glu Val Val Val Leu Gly Ser Gln Glu Gly Ala Met His Thr Ala Leu 
    530                 535                 540                 


Thr Gly Ala Thr Glu Ile Gln Thr Ser Gly Thr Thr Thr Ile Phe Ala 
545                 550                 555                 560 


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Thr Leu Lys Gly 
                565                 570                 575     


Met Ser Tyr Val Met Cys Thr Gly Ser Phe Lys Leu Glu Lys Glu Val 
            580                 585                 590         


Ala Glu Thr Gln His Gly Thr Val Leu Val Gln Val Lys Tyr Glu Gly 
        595                 600                 605             


Thr Asp Ala Pro Cys Lys Ile Pro Phe Ser Ser Gln Asp Glu Lys Gly 
    610                 615                 620                 


Val Thr Gln Asn Gly Arg Leu Ile Thr Ala Asn Pro Ile Val Thr Asp 
625                 630                 635                 640 


Lys Glu Lys Pro Val Asn Ile Glu Ala Glu Pro Pro Phe Gly Glu Ser 
                645                 650                 655     


Tyr Ile Val Val Gly Ala Gly Glu Lys Ala Leu Lys Leu Ser Trp Phe 
            660                 665                 670         


Lys Lys Gly Ser Ser Ile Gly Lys Met Phe Glu Ala Thr Ala Arg Gly 
        675                 680                 685             


Ala Arg Arg Met Ala Ile Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser 
    690                 695                 700                 


Ile Gly Gly Val Phe Thr Ser Val Gly Lys Leu Ile His Gln Ile Phe 
705                 710                 715                 720 


Gly Thr Ala Tyr Gly Val Leu Phe Ser Gly Val Ser Trp Thr Met Lys 
                725                 730                 735     


Ile Gly Ile Gly Ile Leu Leu Thr Trp Leu Gly Leu Asn Ser Arg Ser 
            740                 745                 750         


Thr Ser Leu Ser Met Thr Cys Ile Ala Val Gly Met Val Thr Leu Tyr 
        755                 760                 765             


Leu Gly Val Met Val Gln Ala Asp Ser Gly Cys Val Ile Asn Trp Lys 
    770                 775                 780                 


Gly Arg Glu Leu Lys Cys Gly Ser Gly Ile Phe Val Thr Asn Glu Val 
785                 790                 795                 800 


His Thr Trp Thr Glu Gln Tyr Lys Phe Gln Ala Asp Ser Pro Lys Arg 
                805                 810                 815     


Leu Ser Ala Ala Ile Gly Lys Ala Trp Glu Glu Gly Val Cys Gly Ile 
            820                 825                 830         


Arg Ser Ala Thr Arg Leu Glu Asn Ile Met Trp Lys Gln Ile Ser Asn 
        835                 840                 845             


Glu Leu Asn His Ile Leu Leu Glu Asn Asp Met Lys Phe Thr Val Val 
    850                 855                 860                 


Val Gly Asp Val Ser Gly Ile Leu Ala Gln Gly Lys Lys Met Ile Arg 
865                 870                 875                 880 


Pro Gln Pro Met Glu His Lys Tyr Ser Trp Lys Ser Trp Gly Lys Ala 
                885                 890                 895     


Lys Ile Ile Gly Ala Asp Val Gln Asn Thr Thr Phe Ile Ile Asp Gly 
            900                 905                 910         


Pro Asn Thr Pro Glu Cys Pro Asp Asn Gln Arg Ala Trp Asn Ile Trp 
        915                 920                 925             


Glu Val Glu Asp Tyr Gly Phe Gly Ile Phe Thr Thr Asn Ile Trp Leu 
    930                 935                 940                 


Lys Leu Arg Asp Ser Tyr Thr Gln Val Cys Asp His Arg Leu Met Ser 
945                 950                 955                 960 


Ala Ala Ile Lys Asp Ser Lys Ala Val His Ala Asp Met Gly Tyr Trp 
                965                 970                 975     


Ile Glu Ser Glu Lys Asn Glu Thr Trp Lys Leu Ala Arg Ala Ser Phe 
            980                 985                 990         


Ile Glu Val Lys Thr Cys Ile Trp  Pro Lys Ser His Thr  Leu Trp Ser 
        995                 1000                 1005             


Asn Gly  Val Leu Glu Ser Glu  Met Ile Ile Pro Lys  Ile Tyr Gly 
    1010                 1015                 1020             


Gly Pro  Ile Ser Gln His Asn  Tyr Arg Pro Gly Tyr  Phe Thr Gln 
    1025                 1030                 1035             


Thr Ala  Gly Pro Trp His Leu  Gly Lys Leu Glu Leu  Asp Phe Asp 
    1040                 1045                 1050             


Leu Cys  Glu Gly Thr Thr Val  Val Val Asp Glu His  Cys Gly Asn 
    1055                 1060                 1065             


Arg Gly  Pro Ser Leu Arg Thr  Thr Thr Val Thr Gly  Lys Thr Ile 
    1070                 1075                 1080             


His Glu  Trp Cys Cys Arg Ser  Cys Thr Leu Pro Pro  Leu Arg Phe 
    1085                 1090                 1095             


Lys Gly  Glu Asp Gly Cys Trp  Tyr Gly Met Glu Ile  Arg Pro Val 
    1100                 1105                 1110             


Lys Glu  Lys Glu Glu Asn Leu  Val Lys Ser Met Val  Ser Ala Gly 
    1115                 1120                 1125             


Ser Gly  Glu Val Asp Ser Phe  Ser Leu Gly Leu Leu  Cys Ile Ser 
    1130                 1135                 1140             


Ile Met  Ile Glu Glu Val Met  Arg Ser Arg Trp Ser  Arg Lys Met 
    1145                 1150                 1155             


Leu Met  Thr Gly Thr Leu Ala  Val Phe Leu Leu Leu  Thr Met Gly 
    1160                 1165                 1170             


Gln Leu  Thr Trp Asn Asp Leu  Ile Arg Leu Cys Ile  Met Val Gly 
    1175                 1180                 1185             


Ala Asn  Ala Ser Asp Lys Met  Gly Met Gly Thr Thr  Tyr Leu Ala 
    1190                 1195                 1200             


Leu Met  Ala Thr Phe Arg Met  Arg Pro Met Phe Ala  Val Gly Leu 
    1205                 1210                 1215             


Leu Phe  Arg Arg Leu Thr Ser  Arg Glu Val Leu Leu  Leu Thr Val 
    1220                 1225                 1230             


Gly Leu  Ser Leu Val Ala Ser  Val Glu Leu Pro Asn  Ser Leu Glu 
    1235                 1240                 1245             


Glu Leu  Gly Asp Gly Leu Ala  Met Gly Ile Met Met  Leu Lys Leu 
    1250                 1255                 1260             


Leu Thr  Asp Phe Gln Ser His  Gln Leu Trp Ala Thr  Leu Leu Ser 
    1265                 1270                 1275             


Leu Thr  Phe Val Lys Thr Thr  Phe Ser Leu His Tyr  Ala Trp Lys 
    1280                 1285                 1290             


Thr Met  Ala Met Ile Leu Ser  Ile Val Ser Leu Phe  Pro Leu Cys 
    1295                 1300                 1305             


Leu Ser  Thr Thr Ser Gln Lys  Thr Thr Trp Leu Pro  Val Leu Leu 
    1310                 1315                 1320             


Gly Ser  Leu Gly Cys Lys Pro  Leu Thr Met Phe Leu  Ile Thr Glu 
    1325                 1330                 1335             


Asn Lys  Ile Trp Gly Arg Lys  Ser Trp Pro Leu Asn  Glu Gly Ile 
    1340                 1345                 1350             


Met Ala  Val Gly Ile Val Ser  Ile Leu Leu Ser Ser  Leu Leu Lys 
    1355                 1360                 1365             


Asn Asp  Val Pro Leu Ala Gly  Pro Leu Ile Ala Gly  Gly Met Leu 
    1370                 1375                 1380             


Ile Ala  Cys Tyr Val Ile Ser  Gly Ser Ser Ala Asp  Leu Ser Leu 
    1385                 1390                 1395             


Glu Lys  Ala Ala Glu Val Ser  Trp Glu Glu Glu Ala  Glu His Ser 
    1400                 1405                 1410             


Gly Ala  Ser His Asn Ile Leu  Val Glu Val Gln Asp  Asp Gly Thr 
    1415                 1420                 1425             


Met Lys  Ile Lys Asp Glu Glu  Arg Asp Asp Thr Leu  Thr Ile Leu 
    1430                 1435                 1440             


Leu Lys  Ala Thr Leu Leu Ala  Ile Ser Gly Val Tyr  Pro Met Ser 
    1445                 1450                 1455             


Ile Pro  Ala Thr Leu Phe Val  Trp Tyr Phe Trp Gln  Lys Lys Lys 
    1460                 1465                 1470             


Gln Arg  Ser Gly Val Leu Trp  Asp Thr Pro Ser Pro  Pro Glu Val 
    1475                 1480                 1485             


Glu Arg  Ala Val Leu Asp Asp  Gly Ile Tyr Arg Ile  Leu Gln Arg 
    1490                 1495                 1500             


Gly Leu  Leu Gly Arg Ser Gln  Val Gly Val Gly Val  Phe Gln Glu 
    1505                 1510                 1515             


Gly Val  Phe His Thr Met Trp  His Val Thr Arg Gly  Ala Val Leu 
    1520                 1525                 1530             


Met Tyr  Gln Gly Lys Arg Leu  Glu Pro Ser Trp Ala  Ser Val Lys 
    1535                 1540                 1545             


Lys Asp  Leu Ile Ser Tyr Gly  Gly Gly Trp Arg Phe  Gln Gly Ser 
    1550                 1555                 1560             


Trp Asn  Ala Gly Glu Glu Val  Gln Val Ile Ala Val  Glu Pro Gly 
    1565                 1570                 1575             


Lys Asn  Pro Lys Asn Val Gln  Thr Ala Pro Gly Thr  Phe Lys Thr 
    1580                 1585                 1590             


Pro Glu  Gly Glu Val Gly Ala  Ile Ala Leu Asp Phe  Lys Pro Gly 
    1595                 1600                 1605             


Thr Ser  Gly Ser Pro Ile Val  Asn Arg Glu Gly Lys  Ile Val Gly 
    1610                 1615                 1620             


Leu Tyr  Gly Asn Gly Val Val  Thr Thr Ser Gly Thr  Tyr Val Ser 
    1625                 1630                 1635             


Ala Ile  Ala Gln Ala Lys Ala  Ser Gln Glu Gly Pro  Leu Pro Glu 
    1640                 1645                 1650             


Ile Glu  Asp Glu Val Phe Arg  Lys Arg Asn Leu Thr  Ile Met Asp 
    1655                 1660                 1665             


Leu His  Pro Gly Ser Gly Lys  Thr Arg Arg Tyr Leu  Pro Ala Ile 
    1670                 1675                 1680             


Val Arg  Glu Ala Ile Lys Arg  Lys Leu Arg Thr Leu  Val Leu Ala 
    1685                 1690                 1695             


Pro Thr  Arg Val Val Ala Ser  Glu Met Ala Glu Ala  Leu Lys Gly 
    1700                 1705                 1710             


Met Pro  Ile Arg Tyr Gln Thr  Thr Ala Val Lys Ser  Glu His Thr 
    1715                 1720                 1725             


Gly Lys  Glu Ile Val Asp Leu  Met Cys His Ala Thr  Phe Thr Met 
    1730                 1735                 1740             


Arg Leu  Leu Ser Pro Val Arg  Val Pro Asn Tyr Asn  Met Ile Ile 
    1745                 1750                 1755             


Met Asp  Glu Ala His Phe Thr  Asp Pro Ala Ser Ile  Ala Ala Arg 
    1760                 1765                 1770             


Gly Tyr  Ile Ser Thr Arg Val  Gly Met Gly Glu Ala  Ala Ala Ile 
    1775                 1780                 1785             


Phe Met  Thr Ala Thr Pro Pro  Gly Ser Val Glu Ala  Phe Pro Gln 
    1790                 1795                 1800             


Ser Asn  Ala Val Ile Gln Asp  Glu Glu Arg Asp Ile  Pro Glu Arg 
    1805                 1810                 1815             


Ser Trp  Asn Ser Gly Tyr Asp  Trp Ile Thr Asp Phe  Pro Gly Lys 
    1820                 1825                 1830             


Thr Val  Trp Phe Val Pro Ser  Ile Lys Ser Gly Asn  Asp Ile Ala 
    1835                 1840                 1845             


Asn Cys  Leu Arg Lys Asn Gly  Lys Arg Val Val Gln  Leu Ser Arg 
    1850                 1855                 1860             


Lys Thr  Phe Asp Thr Glu Tyr  Gln Lys Thr Lys Asn  Asn Asp Trp 
    1865                 1870                 1875             


Asp Tyr  Val Val Thr Thr Asp  Ile Ser Glu Met Gly  Ala Asn Phe 
    1880                 1885                 1890             


Arg Ala  Asp Arg Val Ile Asp  Pro Arg Arg Cys Leu  Lys Pro Val 
    1895                 1900                 1905             


Ile Leu  Lys Asp Gly Pro Glu  Arg Val Ile Leu Ala  Gly Pro Met 
    1910                 1915                 1920             


Pro Val  Thr Val Ala Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly 
    1925                 1930                 1935             


Arg Asn  Gln Asn Lys Glu Gly  Asp Gln Tyr Ile Tyr  Met Gly Gln 
    1940                 1945                 1950             


Pro Leu  Lys Asn Asp Glu Asp  His Ala His Trp Thr  Glu Ala Lys 
    1955                 1960                 1965             


Met Leu  Leu Asp Asn Ile Asn  Thr Pro Glu Gly Ile  Ile Pro Ala 
    1970                 1975                 1980             


Leu Phe  Glu Pro Glu Arg Glu  Lys Ser Ala Ala Ile  Asp Gly Glu 
    1985                 1990                 1995             


Tyr Arg  Leu Arg Gly Glu Ala  Arg Lys Thr Phe Val  Glu Leu Met 
    2000                 2005                 2010             


Arg Arg  Gly Asp Leu Pro Val  Trp Leu Ser Tyr Lys  Val Ala Ser 
    2015                 2020                 2025             


Glu Gly  Phe Gln Tyr Ser Asp  Arg Arg Trp Cys Phe  Asp Gly Glu 
    2030                 2035                 2040             


Arg Asn  Asn Gln Val Leu Glu  Glu Asn Met Asp Val  Glu Ile Trp 
    2045                 2050                 2055             


Thr Lys  Glu Gly Glu Arg Lys  Lys Leu Arg Pro Arg  Trp Leu Asp 
    2060                 2065                 2070             


Ala Arg  Thr Tyr Ser Asp Pro  Leu Ala Leu Arg Glu  Phe Lys Glu 
    2075                 2080                 2085             


Phe Ala  Ala Gly Arg Arg Ser  Val Ser Gly Asp Leu  Ile Leu Glu 
    2090                 2095                 2100             


Ile Gly  Lys Leu Pro Gln His  Leu Thr Gln Arg Ala  Gln Asn Ala 
    2105                 2110                 2115             


Leu Asp  Asn Leu Val Met Leu  His Asn Ser Glu Gln  Gly Gly Lys 
    2120                 2125                 2130             


Ala Tyr  Arg His Ala Met Glu  Glu Leu Pro Asp Thr  Ile Glu Thr 
    2135                 2140                 2145             


Leu Met  Leu Leu Ala Leu Ile  Ala Val Leu Thr Gly  Gly Val Thr 
    2150                 2155                 2160             


Leu Phe  Phe Leu Ser Gly Arg  Gly Leu Gly Lys Thr  Ser Ile Gly 
    2165                 2170                 2175             


Leu Leu  Cys Val Ile Ala Ser  Ser Ala Leu Leu Trp  Met Ala Ser 
    2180                 2185                 2190             


Val Glu  Pro His Trp Ile Ala  Ala Ser Ile Ile Leu  Glu Phe Phe 
    2195                 2200                 2205             


Leu Met  Val Leu Leu Ile Pro  Glu Pro Asp Arg Gln  Arg Thr Pro 
    2210                 2215                 2220             


Gln Asp  Asn Gln Leu Ala Tyr  Val Val Ile Gly Leu  Leu Phe Met 
    2225                 2230                 2235             


Ile Leu  Thr Val Ala Ala Asn  Glu Met Gly Leu Leu  Glu Thr Thr 
    2240                 2245                 2250             


Lys Lys  Asp Leu Gly Ile Gly  His Ala Ala Ala Glu  Asn His His 
    2255                 2260                 2265             


His Ala  Ala Met Leu Asp Val  Asp Leu His Pro Ala  Ser Ala Trp 
    2270                 2275                 2280             


Thr Leu  Tyr Ala Val Ala Thr  Thr Ile Ile Thr Pro  Met Met Arg 
    2285                 2290                 2295             


His Thr  Ile Glu Asn Thr Thr  Ala Asn Ile Ser Leu  Thr Ala Ile 
    2300                 2305                 2310             


Ala Asn  Gln Ala Ala Ile Leu  Met Gly Leu Asp Lys  Gly Trp Pro 
    2315                 2320                 2325             


Ile Ser  Lys Met Asp Ile Gly  Val Pro Leu Leu Ala  Leu Gly Cys 
    2330                 2335                 2340             


Tyr Ser  Gln Val Asn Pro Leu  Thr Leu Thr Ala Ala  Val Leu Met 
    2345                 2350                 2355             


Leu Ala  Ala His Tyr Ala Ile  Ile Gly Pro Gly Leu  Gln Ala Lys 
    2360                 2365                 2370             


Ala Thr  Arg Glu Ala Gln Lys  Arg Thr Ala Ala Gly  Ile Met Lys 
    2375                 2380                 2385             


Asn Pro  Thr Val Asp Gly Ile  Val Ala Ile Asp Leu  Asp Pro Val 
    2390                 2395                 2400             


Val Tyr  Asp Ala Lys Phe Glu  Lys Gln Leu Gly Gln  Ile Met Leu 
    2405                 2410                 2415             


Leu Ile  Leu Cys Thr Ser Gln  Ile Leu Leu Met Arg  Thr Thr Trp 
    2420                 2425                 2430             


Ala Leu  Cys Glu Ser Ile Thr  Leu Ala Thr Gly Pro  Leu Thr Thr 
    2435                 2440                 2445             


Leu Trp  Glu Gly Ser Pro Gly  Lys Phe Trp Asn Thr  Thr Ile Ala 
    2450                 2455                 2460             


Val Ser  Met Ala Asn Ile Phe  Arg Gly Ser Tyr Leu  Ala Gly Ala 
    2465                 2470                 2475             


Gly Leu  Ala Phe Ser Leu Met  Lys Ser Leu Gly Gly  Gly Arg Arg 
    2480                 2485                 2490             


Gly Thr  Gly Ala Gln Gly Glu  Thr Leu Gly Glu Lys  Trp Lys Arg 
    2495                 2500                 2505             


Gln Leu  Asn Gln Leu Ser Lys  Ser Glu Phe Asn Thr  Tyr Lys Arg 
    2510                 2515                 2520             


Ser Gly  Ile Ile Glu Val Asp  Arg Ser Glu Ala Lys  Glu Gly Leu 
    2525                 2530                 2535             


Lys Arg  Gly Glu Thr Thr Lys  His Ala Val Ser Arg  Gly Thr Ala 
    2540                 2545                 2550             


Lys Leu  Arg Trp Phe Val Glu  Arg Asn Leu Val Lys  Pro Glu Gly 
    2555                 2560                 2565             


Lys Val  Ile Asp Leu Gly Cys  Gly Arg Gly Gly Trp  Ser Tyr Tyr 
    2570                 2575                 2580             


Cys Ala  Gly Leu Lys Lys Val  Thr Glu Val Lys Gly  Tyr Thr Lys 
    2585                 2590                 2595             


Gly Gly  Pro Gly His Glu Glu  Pro Ile Pro Met Ala  Thr Tyr Gly 
    2600                 2605                 2610             


Trp Asn  Leu Val Lys Leu Tyr  Ser Gly Lys Asp Val  Phe Phe Thr 
    2615                 2620                 2625             


Pro Pro  Glu Lys Cys Asp Thr  Leu Leu Cys Asp Ile  Gly Glu Ser 
    2630                 2635                 2640             


Ser Pro  Asn Pro Thr Ile Glu  Glu Gly Arg Thr Leu  Arg Val Leu 
    2645                 2650                 2655             


Lys Met  Val Glu Pro Trp Leu  Arg Gly Asn Gln Phe  Cys Ile Lys 
    2660                 2665                 2670             


Ile Leu  Asn Pro Tyr Met Pro  Ser Val Val Glu Thr  Leu Glu Gln 
    2675                 2680                 2685             


Met Gln  Arg Lys His Gly Gly  Met Leu Val Arg Asn  Pro Leu Ser 
    2690                 2695                 2700             


Arg Asn  Ser Thr His Glu Met  Tyr Trp Val Ser Cys  Gly Thr Gly 
    2705                 2710                 2715             


Asn Ile  Val Ser Ala Val Asn  Met Thr Ser Arg Met  Leu Leu Asn 
    2720                 2725                 2730             


Arg Phe  Thr Met Ala His Arg  Lys Pro Thr Tyr Glu  Arg Asp Val 
    2735                 2740                 2745             


Asp Leu  Gly Ala Gly Thr Arg  His Val Ala Val Glu  Pro Glu Val 
    2750                 2755                 2760             


Ala Asn  Leu Asp Ile Ile Gly  Gln Arg Ile Glu Asn  Ile Lys Asn 
    2765                 2770                 2775             


Glu His  Lys Ser Thr Trp His  Tyr Asp Glu Asp Asn  Pro Tyr Lys 
    2780                 2785                 2790             


Thr Trp  Ala Tyr His Gly Ser  Tyr Glu Val Lys Pro  Ser Gly Ser 
    2795                 2800                 2805             


Ala Ser  Ser Met Val Asn Gly  Val Val Arg Leu Leu  Thr Lys Pro 
    2810                 2815                 2820             


Trp Asp  Val Ile Pro Met Val  Thr Gln Ile Ala Met  Thr Asp Thr 
    2825                 2830                 2835             


Thr Pro  Phe Gly Gln Gln Arg  Val Phe Lys Glu Lys  Val Asp Thr 
    2840                 2845                 2850             


Arg Thr  Pro Lys Ala Lys Arg  Gly Thr Ala Gln Ile  Met Glu Val 
    2855                 2860                 2865             


Thr Ala  Arg Trp Leu Trp Gly  Phe Leu Ser Arg Asn  Lys Lys Pro 
    2870                 2875                 2880             


Arg Ile  Cys Thr Arg Glu Glu  Phe Thr Arg Lys Val  Arg Ser Asn 
    2885                 2890                 2895             


Ala Ala  Ile Gly Ala Val Phe  Val Asp Glu Asn Gln  Trp Asn Ser 
    2900                 2905                 2910             


Ala Lys  Glu Ala Val Glu Asp  Glu Arg Phe Trp Asp  Leu Val His 
    2915                 2920                 2925             


Arg Glu  Arg Glu Leu His Lys  Gln Gly Lys Cys Ala  Thr Cys Val 
    2930                 2935                 2940             


Tyr Asn  Met Met Gly Lys Arg  Glu Lys Lys Leu Gly  Glu Phe Gly 
    2945                 2950                 2955             


Lys Ala  Lys Gly Ser Arg Ala  Ile Trp Tyr Met Trp  Leu Gly Ala 
    2960                 2965                 2970             


Arg Phe  Leu Glu Phe Glu Ala  Leu Gly Phe Met Asn  Glu Asp His 
    2975                 2980                 2985             


Trp Phe  Ser Arg Glu Asn Ser  Leu Ser Gly Val Glu  Gly Glu Gly 
    2990                 2995                 3000             


Leu His  Lys Leu Gly Tyr Ile  Leu Arg Asp Ile Ser  Lys Ile Pro 
    3005                 3010                 3015             


Gly Gly  Asn Met Tyr Ala Asp  Asp Thr Ala Gly Trp  Asp Thr Arg 
    3020                 3025                 3030             


Ile Thr  Glu Asp Asp Leu Gln  Asn Glu Ala Lys Ile  Thr Asp Ile 
    3035                 3040                 3045             


Met Glu  Pro Glu His Ala Leu  Leu Ala Thr Ser Ile  Phe Lys Leu 
    3050                 3055                 3060             


Thr Tyr  Gln Asn Lys Val Val  Arg Val Gln Arg Pro  Ala Lys Asn 
    3065                 3070                 3075             


Gly Thr  Val Met Asp Val Ile  Ser Arg Arg Asp Gln  Arg Gly Ser 
    3080                 3085                 3090             


Gly Gln  Val Gly Thr Tyr Gly  Leu Asn Thr Phe Thr  Asn Met Glu 
    3095                 3100                 3105             


Ala Gln  Leu Ile Arg Gln Met  Glu Ser Glu Gly Ile  Phe Ser Pro 
    3110                 3115                 3120             


Ser Glu  Leu Glu Thr Pro Asn  Leu Ala Glu Arg Val  Leu Asp Trp 
    3125                 3130                 3135             


Leu Lys  Lys His Gly Thr Glu  Arg Leu Lys Arg Met  Ala Ile Ser 
    3140                 3145                 3150             


Gly Asp  Asp Cys Val Val Lys  Pro Ile Asp Asp Arg  Phe Ala Thr 
    3155                 3160                 3165             


Ala Leu  Thr Ala Leu Asn Asp  Met Gly Lys Val Arg  Lys Asp Ile 
    3170                 3175                 3180             


Pro Gln  Trp Glu Pro Ser Lys  Gly Trp Asn Asp Trp  Gln Gln Val 
    3185                 3190                 3195             


Pro Phe  Cys Ser His His Phe  His Gln Leu Ile Met  Lys Asp Gly 
    3200                 3205                 3210             


Arg Glu  Ile Val Val Pro Cys  Arg Asn Gln Asp Glu  Leu Val Gly 
    3215                 3220                 3225             


Arg Ala  Arg Val Ser Gln Gly  Ala Gly Trp Ser Leu  Arg Glu Thr 
    3230                 3235                 3240             


Ala Cys  Leu Gly Lys Ser Tyr  Ala Gln Met Trp Gln  Leu Met Tyr 
    3245                 3250                 3255             


Phe His  Arg Arg Asp Leu Arg  Leu Ala Ala Asn Ala  Ile Cys Ser 
    3260                 3265                 3270             


Ala Val  Pro Val Asp Trp Val  Pro Thr Ser Arg Thr  Thr Trp Ser 
    3275                 3280                 3285             


Ile His  Ala His His Gln Trp  Met Thr Thr Glu Asp  Met Leu Ser 
    3290                 3295                 3300             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Pro Trp  Met Glu Asp 
    3305                 3310                 3315             


Lys Thr  His Val Ser Ser Trp  Glu Asp Val Pro Tyr  Leu Gly Lys 
    3320                 3325                 3330             


Arg Glu  Asp Gln Trp Cys Gly  Ser Leu Ile Gly Leu  Thr Ala Arg 
    3335                 3340                 3345             


Ala Thr  Trp Ala Thr Asn Ile  Gln Val Ala Ile Asn  Gln Val Arg 
    3350                 3355                 3360             


Arg Leu  Ile Gly Asn Glu Asn  Tyr Leu Asp Phe Met  Thr Ser Met 
    3365                 3370                 3375             


Lys Arg  Phe Lys Asn Glu Ser  Asp Pro Glu Gly Ala  Leu Trp 
    3380                 3385                 3390         


<210>  12
<211>  10735
<212>  DNA
<213>  Dengue virus serotype 1

<400>  12
agttgttagt ctacgtggac cgacaagaac agtttcgaat cggaagcttg cttaacgtag       60

ttctaacagt tttttattag agagcagatc tctgatgaac aaccaacgga aaaagacggg      120

tcgaccgtct ttcaatatgc tgaaacgcgc gagaaaccgc gtgtcaactg tttcacagtt      180

ggcgaagaga ttctcaaaag gattgctttc aggccaagga cccatgaaat tggtgatggc      240

ttttatagca ttcctaagat ttctagccat acctccaaca gcaggaattt tggctagatg      300

gggctcattc aagaagaatg gagcgatcaa agtgttacgg ggtttcaaga aagaaatctc      360

aaacatgttg aacataatga acaggaggaa aagatctgtg accatgctcc tcatgctgct      420

gcccacagcc ctggcgttcc atctgaccac ccgaggggga gagccgcaca tgatagttag      480

caagcaggaa agaggaaaat cacttttgtt taagacctct gcaggtgtca acatgtgcac      540

ccttattgca atggatttgg gagagttatg tgaggacaca atgacctaca aatgcccccg      600

gatcactgag acggaaccag atgacgttga ctgttggtgc aatgccacgg agacatgggt      660

gacctatgga acatgttctc aaactggtga acaccgacga gacaaacgtt ccgtcgcact      720

ggcaccacac gtagggcttg gtctagaaac aagaaccgaa acgtggatgt cctctgaagg      780

cgcttggaaa caaatacaaa aagtggagac ctgggttctg agacacccag gattcacggt      840

gatagccctt tttctagcac atgccatagg aacatccatc acccagaaag ggatcatttt      900

tattttgctg atgctggtaa ctccatccat ggccatgcgg tgcgtgggaa taggcaacag      960

agacttcgtg gaaggactgt caggagctac gtgggtggat gtggtactgg agcatggaag     1020

ttgcgtcact accatggcaa aagacaaacc aacactggac attgaactct tgaagacgga     1080

ggtcacaaac cctgccgtcc tgcgcaaact gtgcattgaa gctaaaatat caaacaccac     1140

caccgattcg agatgtccaa cacaaggaga agccacgctg gtggaagaac aggacacgaa     1200

ctttgtgtgt cgacgaacgt tcgtggacag aggctggggc aatggttgtg ggctattcgg     1260

aaaaggtagc ttaataacgt gtgctaagtt taagtgtgtg acaaaactgg aaggaaagat     1320

agtccaatat gaaaacttaa aatattcagt gatagtcacc gtacacactg gagaccagca     1380

ccaagttgga aatgagacca cagaacatgg aacaactgca accataacac ctcaagctcc     1440

cacgtcggaa atacagctga cagactacgg agctctaaca ttggattgtt cacctagaac     1500

agggctagac tttaatgaga tggtgttgtt gacaatggaa aaaaaatcat ggctcgtcca     1560

caaacaatgg tttctagact taccactgcc ttggacctcg ggggcttcaa catcccaaga     1620

gacttggaat agacaagact tgctggtcac atttaagaca gctcatgcaa aaaagcagga     1680

agtagtcgta ctaggatcac aagaaggagc aatgcacact gcgttgactg gagcgacaga     1740

aatccaaacg tctggaacga caacaatttt tgcaggacac ctgaaatgca gactaaaaat     1800

ggataaactg actttaaaag ggatgtcata tgtaatgtgc acagggtcat tcaagttaga     1860

gaaggaagtg gctgagaccc agcatggaac tgttctagtg caggttaaat acgaaggaac     1920

agatgcacca tgcaagatcc ccttctcgtc ccaagatgag aagggagtaa cccagaatgg     1980

gagattgata acagccaacc ccatagtcac tgacaaagaa aaaccagtca acattgaagc     2040

ggagccacct tttggtgaga gctacattgt ggtaggagca ggtgaaaaag ctttgaaact     2100

aagctggttc aagaagggaa gcagtatagg gaaaatgttt gaagcaactg cccgtggagc     2160

acgaaggatg gccatcctgg gagatactgc atgggacttc ggttctatag gaggggtgtt     2220

cacgtctgtg ggaaaactga tacaccagat ttttgggact gcgtatggag ttttgttcag     2280

cggtgtttct tggaccatga agataggaat agggattctg ctgacatggc taggattaaa     2340

ctcaaggagc acgtcccttt caatgacgtg tatcgcagtt ggcatggtca cactgtacct     2400

aggagtcatg gttcaggcgg actcgggatg tgtaatcaac tggaaaggca gagaactcaa     2460

atgtggaagc ggcatttttg tcaccaatga agtccacacc tggacagagc aatataaatt     2520

ccaggccgac tcccctaaga gactatcagc ggccattggg aaggcatggg aggagggtgt     2580

gtgtggaatt cgatcagcca ctcgtctcga gaacatcatg tggaagcaaa tatcaaatga     2640

attaaaccac atcttacttg aaaatgacat gaaatttaca gtggtcgtag gagacgttag     2700

tggaatcttg gcccaaggaa agaaaatgat taggccacaa cccatggaac acaaatactc     2760

gtggaaaagc tggggaaaag ccaaaatcat aggagcagat gtacagaata ccaccttcat     2820

catcgacggc ccaaacaccc cagaatgccc tgataaccaa agagcatgga acatttggga     2880

agttgaagac tatggatttg gaattttcac gacaaacata tggttgaaat tgcgtgactc     2940

ctacactcaa gtgtgtgacc accggctaat gtcagctgcc atcaaggata gcaaagcagt     3000

ccatgctgac atggggtact ggatagaaag tgaaaagaac gagacttgga agttggcaag     3060

agcctccttc atagaagtta agacatgcat ctggccaaaa tcccacactc tatggagcaa     3120

tggagtcctg gaaagtgaga tgataatccc aaagatatat ggaggaccaa tatctcagca     3180

caactacaga ccaggatatt tcacacaaac agcagggccg tggcacttgg gcaagttaga     3240

actagatttt gatttatgtg aaggtaccac tgttgttgtg gatgaacatt gtggaaatcg     3300

aggaccatct cttagaacca caacagtcac aggaaagaca atccatgaat ggtgctgtag     3360

atcttgcacg ttaccccccc tacgtttcaa aggagaagac gggtgctggt acggcatgga     3420

aatcagacca gtcaaggaga aggaagagaa cctagttaag tcaatggtct ctgcagggtc     3480

aggagaagtg gacagttttt cactaggact gctatgcata tcaataatga tcgaagaggt     3540

aatgagatcc agatggagca gaaaaatgct gatgactgga acattggctg tgttcctcct     3600

tctcacaatg ggacaattga catggaatga tctgatcagg ctatgtatca tggttggagc     3660

caacgcttca gacaagatgg ggatgggaac aacgtaccta gctttgatgg ccactttcag     3720

aatgagacca atgttcgcag tcgggctact gtttcgcaga ttaacatcta gagaagttct     3780

tcttcttaca gttggattga gtctggtggc atctgtagaa ctaccaaatt ccttagagga     3840

gctaggggat ggacttgcaa tgggcatcat gatgttgaaa ttactgactg attttcagtc     3900

acatcagcta tgggctacct tgctgtcttt aacatttgtc aaaacaactt tttcattgca     3960

ctatgcatgg aagacaatgg ctatgatact gtcaattgta tctctcttcc ctttatgcct     4020

gtccacgact tctcaaaaaa caacatggct tccggtgttg ctgggatctc ttggatgcaa     4080

accactaacc atgtttctta taacagaaaa caaaatctgg ggaaggaaaa gctggcctct     4140

caatgaagga attatggctg ttggaatagt tagcattctt ctaagttcac ttctcaagaa     4200

tgatgtgcca ctagctggcc cactaatagc tggaggcatg ctaatagcat gttatgtcat     4260

atctggaagc tcggccgatt tatcactgga gaaagcggct gaggtctcct gggaagaaga     4320

agcagaacac tctggtgcct cacacaacat actagtggag gtccaagatg atggaaccat     4380

gaagataaag gatgaagaga gagatgacac actcaccatt ctcctcaaag caactctgct     4440

agcaatctca ggggtatacc caatgtcaat accggcgacc ctctttgtgt ggtatttttg     4500

gcagaaaaag aaacagagat caggagtgct atgggacaca cccagccctc cagaagtgga     4560

aagagcagtc cttgatgatg gcatttatag aattctccaa agaggattgt tgggcaggtc     4620

tcaagtagga gtaggagttt ttcaagaagg cgtgttccac acaatgtggc acgtcaccag     4680

gggagctgtc ctcatgtacc aagggaagag actggaacca agttgggcca gtgtcaaaaa     4740

agacttgatc tcatatggag gaggttggag gtttcaagga tcctggaacg cgggagaaga     4800

agtgcaggtg attgctgttg aaccggggaa gaaccccaaa aatgtacaga cagcgccggg     4860

taccttcaag acccctgaag gcgaagttgg agccatagct ctagacttta aacccggcac     4920

atctggatct cctatcgtga acagagaggg aaaaatagta ggtctttatg gaaatggagt     4980

ggtgacaaca agtggtacct acgtcagtgc catagctcaa gctaaagcat cacaagaagg     5040

gcctctacca gagattgagg acgaggtgtt taggaaaaga aacttaacaa taatggacct     5100

acatccagga tcgggaaaaa caagaagata ccttccagcc atagtccgtg aggccataaa     5160

aagaaagctg cgcacgctag tcttagctcc cacaagagtt gtcgcttctg aaatggcaga     5220

ggcgctcaag ggaatgccaa taaggtatca gacaacagca gtgaagagtg aacacacggg     5280

aaaggagata gttgacctta tgtgtcacgc cactttcact atgcgtctcc tgtctcctgt     5340

gagagttccc aattataata tgattatcat ggatgaagca catttcaccg atccagccag     5400

catagcagcc agagggtata tctcaacccg agtgggtatg ggtgaagcag ctgcgatttt     5460

catgacagcc actccccccg gatcggtgga ggcctttcca cagagcaatg cagttatcca     5520

agatgaggaa agagacattc ctgaaagatc atggaactca ggctatgact ggatcactga     5580

tttcccaggt aaaacagtct ggtttgttcc aagcatcaaa tcaggaaatg acattgccaa     5640

ctgtttaaga aagaatggga aacgggtggt ccaattgagc agaaaaactt ttgacactga     5700

gtaccagaaa acaaaaaata acgactggga ctatgttgtc acaacagaca tatccgaaat     5760

gggagcaaac ttccgagccg acagggtaat agacccgagg cggtgcctga aaccggtaat     5820

actaaaagat ggcccagagc gtgtcattct agccggaccg atgccagtga ctgtggctag     5880

cgccgcccag aggagaggaa gaattggaag gaaccaaaat aaggaaggcg atcagtatat     5940

ttacatggga cagcctctaa aaaatgatga ggaccacgcc cattggacag aagcaaaaat     6000

gctccttgac aacataaaca caccagaagg gattatccca gccctctttg agccggagag     6060

agaaaagagt gcagcaatag acggggaata cagactacgg ggtgaagcga ggaaaacgtt     6120

cgtggagctc atgagaagag gagatctacc tgtctggcta tcctacaaag ttgcctcaga     6180

aggcttccag tactccgaca gaaggtggtg ctttgatggg gaaaggaaca accaggtgtt     6240

ggaggagaac atggacgtgg agatctggac aaaagaagga gaaagaaaga aactacgacc     6300

ccgctggctg gatgccagaa catactctga cccactggct ctgcgcgaat tcaaagagtt     6360

cgcagcagga agaagaagcg tctcaggtga cctaatatta gaaataggga aacttccaca     6420

acatttaacg caaagggccc agaacgcctt ggacaatctg gttatgttgc acaactctga     6480

acaaggagga aaagcctata gacacgccat ggaagaacta ccagacacca tagaaacgtt     6540

aatgctccta gctttgatag ctgtgctgac tggtggagtg acgttgttct tcctatcagg     6600

aaggggtcta ggaaaaacat ccattggcct actctgcgtg attgcctcaa gtgcactgtt     6660

atggatggcc agtgtggaac cccattggat agcggcctct atcatactgg agttctttct     6720

gatggtgttg cttattccag agccggacag acagcgcact ccacaagaca accagctagc     6780

atacgtggtg ataggtctgt tattcatgat attgacagtg gcagccaatg agatgggatt     6840

actggaaacc acaaagaagg acctggggat tggtcatgca gctgctgaaa accaccatca     6900

tgctgcaatg ctggacgtag acctacatcc agcttcagcc tggactctct atgcagtggc     6960

cacaacaatt atcactccca tgatgagaca cacaattgaa aacacaacgg caaatatttc     7020

cctgacagct attgcaaacc aggcagctat attgatggga cttgacaagg gatggccaat     7080

atcaaagatg gacataggag ttccacttct cgccttgggg tgctattctc aggtgaaccc     7140

gctgacgctg acagcggcgg tattgatgct agcggctcat tatgccataa ttggacccgg     7200

actgcaagca aaagctacta gagaagctca aaaaaggaca gcagccggaa taatgaaaaa     7260

cccaactgtc gacgggatcg ttgcaataga tttggaccct gtggtttacg atgcaaaatt     7320

tgaaaaacag ctaggccaaa taatgttgtt gatactttgc acatcacaga tcctcctgat     7380

gcggaccaca tgggccttgt gtgaatccat cacactagcc actggacctc tgactacgct     7440

ttgggaggga tctccaggaa aattctggaa caccacgata gcggtgtcca tggcaaacat     7500

ttttagggga agttatctag caggagcagg tctggccttt tcattaatga aatctctagg     7560

aggaggtagg agaggcacgg gagcccaagg ggaaacactg ggagaaaaat ggaaaagaca     7620

gctaaaccaa ttgagcaagt cagaattcaa cacttacaaa aggagtggga ttatagaggt     7680

ggatagatct gaagccaaag aggggttaaa aagaggagaa acgactaaac acgcagtgtc     7740

gagaggaacg gccaaactga ggtggtttgt ggagaggaac cttgtgaaac cagaagggaa     7800

agtcatagac ctcggttgtg gaagaggtgg ctggtcatat tattgcgctg ggctgaagaa     7860

agtcacagaa gtgaaaggat acacgaaagg aggacctgga catgaggaac caatcccaat     7920

ggcaacctat ggatggaacc tagtaaagct atactccggg aaagatgtat tctttacacc     7980

acctgagaaa tgtgacaccc tcttgtgtga tattggtgag tcctctccga acccaactat     8040

agaagaagga agaacgttac gtgttctaaa gatggtggaa ccatggctca gaggaaacca     8100

attttgcata aaaattctaa atccctatat gccgagtgtg gtagaaactt tggagcaaat     8160

gcaaagaaaa catggaggaa tgctagtgcg aaatccactc tcaagaaact ccactcatga     8220

aatgtactgg gtttcatgtg gaacaggaaa cattgtgtca gcagtaaaca tgacatctag     8280

aatgctgcta aatcgattca caatggctca caggaagcca acatatgaaa gagacgtgga     8340

cttaggcgct ggaacaagac atgtggcagt agaaccagag gtggccaacc tagatatcat     8400

tggccagagg atagagaata taaaaaatga acacaaatca acatggcatt atgatgagga     8460

caatccatac aaaacatggg cctatcatgg atcatatgag gtcaagccat caggatcagc     8520

ctcatccatg gtcaatggtg tggtgagact gctaaccaaa ccatgggatg tcattcccat     8580

ggtcacacaa atagccatga ctgacaccac accctttgga caacagaggg tgtttaaaga     8640

gaaagttgac acgcgtacac caaaagcgaa acgaggcaca gcacaaatta tggaggtgac     8700

agccaggtgg ttatggggtt ttctctctag aaacaaaaaa cccagaatct gcacaagaga     8760

ggagttcaca agaaaagtca ggtcaaacgc agctattgga gcagtgttcg ttgatgaaaa     8820

tcaatggaac tcagcaaaag aggcagtgga agatgaacgg ttctgggacc ttgtgcacag     8880

agagagggag cttcataaac aaggaaaatg tgccacgtgt gtctacaaca tgatgggaaa     8940

gagagagaaa aaattaggag agttcggaaa ggcaaaagga agtcgcgcaa tatggtacat     9000

gtggttggga gcgcgctttt tagagtttga agcccttggt ttcatgaatg aagatcactg     9060

gttcagcaga gagaattcac tcagtggagt ggaaggagaa ggactccaca aacttggata     9120

catactcaga gacatatcaa agattccagg gggaaatatg tatgcagatg acacagccgg     9180

atgggacaca agaataacag aggatgatct tcagaatgag gccaaaatca ctgacatcat     9240

ggaacctgaa catgccctat tggccacgtc aatctttaag ctaacctacc aaaacaaggt     9300

agtaagggtg cagagaccag cgaaaaatgg aaccgtgatg gatgtcatat ccagacgtga     9360

ccagagagga agtggacagg ttggaaccta tggcttaaac accttcacca acatggaggc     9420

ccaactaata agacaaatgg agtctgaggg aatcttttca cccagcgaat tggaaacccc     9480

aaatctagcc gaaagagtcc tcgactggtt gaaaaaacat ggcaccgaga ggctgaaaag     9540

aatggcaatc agtggagatg actgtgtggt gaaaccaatt gatgacagat ttgcaacagc     9600

cttaacagct ttgaatgaca tgggaaaggt aagaaaagac ataccgcaat gggaaccttc     9660

aaaaggatgg aatgattggc aacaagtgcc tttctgttca caccatttcc accagctgat     9720

tatgaaggat gggagggaga tagtggtgcc atgccgcaac caagatgaac ttgtaggtag     9780

ggccagagta tcacaaggcg ccggatggag cttgagagaa actgcatgcc taggcaagtc     9840

atatgcacaa atgtggcagc tgatgtactt ccacaggaga gacttgagat tagcggctaa     9900

tgctatctgt tcagccgttc cagttgattg ggtcccaacc agccgtacca cctggtcgat     9960

ccatgcccac catcaatgga tgacaacaga agacatgttg tcagtgtgga atagggtttg    10020

gatagaggaa aacccatgga tggaggacaa gactcatgtg tccagttggg aagacgttcc    10080

atacctagga aaaagggaag atcaatggtg tggatcccta ataggcttaa cagcacgagc    10140

cacctgggcc accaacatac aagtggccat aaaccaagtg agaaggctca ttgggaatga    10200

gaattatcta gacttcatga catcaatgaa gagattcaaa aacgagagtg atcccgaagg    10260

ggcactctgg taagccaact cattcacaaa ataaaggaaa ataaaaaatc aaacaaggca    10320

agaagtcagg ccggattaag ccatagcacg gtaagagcta tgctgcctgt gagccccgtc    10380

caaggacgta aaatgaagtc aggccgaaag ccacggttcg agcaagccgt gctgcctgta    10440

gctccatcgt ggggatgtaa aaacccggga ggctgcaaac catggaagct gtacgcatgg    10500

ggtagcagac tagtggttag aggagacccc tcccaagaca caacgcagca gcggggccca    10560

agccaggagg aagctgtact cctggtggaa ggactagagg ttagaggaga ccccccgcac    10620

aacaacaaac agcatattga cgctgggaga gaccagagat cctgctgtct ctacagcatc    10680

attccaggca cagaacgcca gaaaatggaa tggtgctgtt gaatcaacag gttct         10735


<210>  13
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DENV1 NS1

<400>  13

Asp Ser Gly Cys Val Ile Asn Trp Lys Gly Arg Glu Leu Lys Cys Gly 
1               5                   10                  15      


Ser Gly Ile Phe Val Thr Asn Glu Val His Thr Trp Thr Glu Gln Tyr 
            20                  25                  30          


Lys Phe Gln Ala Asp Ser Pro Lys Arg Leu Ser Ala Ala Ile Gly Lys 
        35                  40                  45              


Ala Trp Glu Glu Gly Val Cys Gly Ile Arg Ser Ala Thr Arg Leu Glu 
    50                  55                  60                  


Asn Ile Met Trp Lys Gln Ile Ser Asn Glu Leu Asn His Ile Leu Leu 
65                  70                  75                  80  


Glu Asn Asp Met Lys Phe Thr Val Val Val Gly Asp Val Ser Gly Ile 
                85                  90                  95      


Leu Ala Gln Gly Lys Lys Met Ile Arg Pro Gln Pro Met Glu His Lys 
            100                 105                 110         


Tyr Ser Trp Lys Ser Trp Gly Lys Ala Lys Ile Ile Gly Ala Asp Val 
        115                 120                 125             


Gln Asn Thr Thr Phe Ile Ile Asp Gly Pro Asn Thr Pro Glu Cys Pro 
    130                 135                 140                 


Asp Asn Gln Arg Ala Trp Asn Ile Trp Glu Val Glu Asp Tyr Gly Phe 
145                 150                 155                 160 


Gly Ile Phe Thr Thr Asn Ile Trp Leu Lys Leu Arg Asp Ser Tyr Thr 
                165                 170                 175     


Gln Val Cys Asp His Arg Leu Met Ser Ala Ala Ile Lys Asp Ser Lys 
            180                 185                 190         


Ala Val His Ala Asp Met Gly Tyr Trp Ile Glu Ser Glu Lys Asn Glu 
        195                 200                 205             


Thr Trp Lys Leu Ala Arg Ala Ser Phe Ile Glu Val Lys Thr Cys Ile 
    210                 215                 220                 


Trp Pro Lys Ser His Thr Leu Trp Ser Asn Gly Val Leu Glu Ser Glu 
225                 230                 235                 240 


Met Ile Ile Pro Lys Ile Tyr Gly Gly Pro Ile Ser Gln His Asn Tyr 
                245                 250                 255     


Arg Pro Gly Tyr Phe Thr Gln Thr Ala Gly Pro Trp His Leu Gly Lys 
            260                 265                 270         


Leu Glu Leu Asp Phe Asp Leu Cys Glu Gly Thr Thr Val Val Val Asp 
        275                 280                 285             


Glu His Cys Gly Asn Arg Gly Pro Ser Leu Arg Thr Thr Thr Val Thr 
    290                 295                 300                 


Gly Lys Thr Ile His Glu Trp Cys Cys Arg Ser Cys Thr Leu Pro Pro 
305                 310                 315                 320 


Leu Arg Phe Lys Gly Glu Asp Gly Cys Trp Tyr Gly Met Glu Ile Arg 
                325                 330                 335     


Pro Val Lys Glu Lys Glu Glu Asn Leu Val Lys Ser Met Val Ser Ala 
            340                 345                 350         


His His His His His His 
        355             


<210>  14
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DENV2 NS1

<400>  14

Asp Ser Gly Cys Val Val Ser Trp Lys Asn Lys Glu Leu Lys Cys Gly 
1               5                   10                  15      


Ser Gly Ile Phe Ile Thr Asp Asn Val His Thr Trp Thr Glu Gln Tyr 
            20                  25                  30          


Lys Phe Gln Pro Glu Ser Pro Ser Lys Leu Ala Ser Ala Ile Gln Lys 
        35                  40                  45              


Ala His Glu Glu Gly Ile Cys Gly Ile Arg Ser Val Thr Arg Leu Glu 
    50                  55                  60                  


Asn Leu Met Trp Lys Gln Ile Thr Pro Glu Leu Asn His Ile Leu Ser 
65                  70                  75                  80  


Glu Asn Glu Val Lys Leu Thr Ile Met Thr Gly Asp Ile Lys Gly Ile 
                85                  90                  95      


Met Gln Ala Gly Lys Arg Ser Leu Arg Pro Gln Pro Thr Glu Leu Lys 
            100                 105                 110         


Tyr Ser Trp Lys Thr Trp Gly Lys Ala Lys Met Leu Ser Thr Glu Ser 
        115                 120                 125             


His Asn Gln Thr Phe Leu Ile Asp Gly Pro Glu Thr Ala Glu Cys Pro 
    130                 135                 140                 


Asn Thr Asn Arg Ala Trp Asn Ser Leu Glu Val Glu Asp Tyr Gly Phe 
145                 150                 155                 160 


Gly Val Phe Thr Thr Asn Ile Trp Leu Lys Leu Lys Glu Lys Gln Asp 
                165                 170                 175     


Val Phe Cys Asp Ser Lys Leu Met Ser Ala Ala Ile Lys Asp Asn Arg 
            180                 185                 190         


Ala Val His Ala Asp Met Gly Tyr Trp Ile Glu Ser Ala Leu Asn Asp 
        195                 200                 205             


Thr Trp Lys Ile Glu Lys Ala Ser Phe Ile Glu Val Lys Asn Cys His 
    210                 215                 220                 


Trp Pro Lys Ser His Thr Leu Trp Ser Asn Gly Val Leu Glu Ser Glu 
225                 230                 235                 240 


Met Ile Ile Pro Lys Asn Leu Ala Gly Pro Val Ser Gln His Asn Tyr 
                245                 250                 255     


Arg Pro Gly Tyr His Thr Gln Ile Thr Gly Pro Trp His Leu Gly Lys 
            260                 265                 270         


Leu Glu Met Asp Phe Asp Phe Cys Asp Gly Thr Thr Val Val Val Thr 
        275                 280                 285             


Glu Asp Cys Gly Asn Arg Gly Pro Ser Leu Arg Thr Thr Thr Ala Ser 
    290                 295                 300                 


Gly Lys Leu Ile Thr Glu Trp Cys Cys Arg Ser Cys Thr Leu Pro Pro 
305                 310                 315                 320 


Leu Arg Tyr Arg Gly Glu Asp Gly Cys Trp Tyr Gly Met Glu Ile Arg 
                325                 330                 335     


Pro Leu Lys Glu Lys Glu Glu Asn Leu Val Asn Ser Leu Val Thr Ala 
            340                 345                 350         


His His His His His His 
        355             


<210>  15
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DENV3 NS1

<400>  15

Asp Met Gly Cys Val Ile Asn Trp Lys Gly Lys Glu Leu Lys Cys Gly 
1               5                   10                  15      


Ser Gly Ile Phe Val Thr Asn Glu Val His Thr Trp Thr Glu Gln Tyr 
            20                  25                  30          


Lys Phe Gln Ala Asp Ser Pro Lys Arg Leu Ala Thr Ala Ile Ala Gly 
        35                  40                  45              


Ala Trp Glu Asn Gly Val Cys Gly Ile Arg Ser Thr Thr Arg Met Glu 
    50                  55                  60                  


Asn Leu Leu Trp Lys Gln Ile Ala Asn Glu Leu Asn Tyr Ile Leu Trp 
65                  70                  75                  80  


Glu Asn Asn Ile Lys Leu Thr Val Val Val Gly Asp Thr Leu Gly Val 
                85                  90                  95      


Leu Glu Gln Gly Lys Arg Thr Leu Thr Pro Gln Pro Met Glu Leu Lys 
            100                 105                 110         


Tyr Ser Trp Lys Thr Trp Gly Lys Ala Lys Ile Val Thr Ala Glu Thr 
        115                 120                 125             


Gln Asn Ser Ser Phe Ile Ile Asp Gly Pro Asn Thr Pro Glu Cys Pro 
    130                 135                 140                 


Ser Ala Ser Arg Ala Trp Asn Val Trp Glu Val Glu Asp Tyr Gly Phe 
145                 150                 155                 160 


Gly Val Phe Thr Thr Asn Ile Trp Leu Lys Leu Arg Glu Val Tyr Thr 
                165                 170                 175     


Gln Leu Cys Asp His Arg Leu Met Ser Ala Ala Val Lys Asp Glu Arg 
            180                 185                 190         


Ala Val His Ala Asp Met Gly Tyr Trp Ile Glu Ser Gln Lys Asn Gly 
        195                 200                 205             


Ser Trp Lys Leu Glu Lys Ala Ser Leu Ile Glu Val Lys Thr Cys Thr 
    210                 215                 220                 


Trp Pro Lys Ser His Thr Leu Trp Thr Asn Gly Val Leu Glu Ser Asp 
225                 230                 235                 240 


Met Ile Ile Pro Lys Ser Leu Ala Gly Pro Ile Ser Gln His Asn Tyr 
                245                 250                 255     


Arg Pro Gly Tyr His Thr Gln Thr Ala Gly Pro Trp His Leu Gly Lys 
            260                 265                 270         


Leu Glu Leu Asp Phe Asn Tyr Cys Glu Gly Thr Thr Val Val Ile Thr 
        275                 280                 285             


Glu Ser Cys Gly Thr Arg Gly Pro Ser Leu Arg Thr Thr Thr Val Ser 
    290                 295                 300                 


Gly Lys Leu Ile His Glu Trp Cys Cys Arg Ser Cys Thr Leu Pro Pro 
305                 310                 315                 320 


Leu Arg Tyr Met Gly Glu Asp Gly Cys Trp Tyr Gly Met Glu Ile Arg 
                325                 330                 335     


Pro Ile Ser Glu Lys Glu Glu Asn Met Val Lys Ser Leu Val Ser Ala 
            340                 345                 350         


His His His His His His 
        355             


<210>  16
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DENV4 NS1

<400>  16

Asp Met Gly Cys Val Ala Ser Trp Ser Gly Lys Glu Leu Lys Cys Gly 
1               5                   10                  15      


Ser Gly Ile Phe Val Val Asp Asn Val His Thr Trp Thr Glu Gln Tyr 
            20                  25                  30          


Lys Phe Gln Pro Glu Ser Pro Ala Arg Leu Ala Ser Ala Ile Leu Asn 
        35                  40                  45              


Ala His Lys Asp Gly Val Cys Gly Ile Arg Ser Thr Thr Arg Leu Glu 
    50                  55                  60                  


Asn Val Met Trp Lys Gln Ile Thr Asn Glu Leu Asn Tyr Val Leu Trp 
65                  70                  75                  80  


Glu Gly Gly His Asp Leu Thr Val Val Ala Gly Asp Val Lys Gly Val 
                85                  90                  95      


Leu Thr Lys Gly Lys Arg Ala Leu Thr Pro Pro Val Ser Asp Leu Lys 
            100                 105                 110         


Tyr Ser Trp Lys Thr Trp Gly Lys Ala Lys Ile Phe Thr Pro Glu Ala 
        115                 120                 125             


Arg Asn Ser Thr Phe Leu Ile Asp Gly Pro Asp Thr Ser Glu Cys Pro 
    130                 135                 140                 


Asn Glu Arg Arg Ala Trp Asn Ser Leu Glu Val Glu Asp Tyr Gly Phe 
145                 150                 155                 160 


Gly Met Phe Thr Thr Asn Ile Trp Met Lys Phe Arg Glu Gly Ser Ser 
                165                 170                 175     


Glu Val Cys Asp His Arg Leu Met Ser Ala Ala Ile Lys Asp Gln Lys 
            180                 185                 190         


Ala Val His Ala Asp Met Gly Tyr Trp Ile Glu Ser Ser Lys Asn Gln 
        195                 200                 205             


Thr Trp Gln Ile Glu Lys Ala Ser Leu Ile Glu Val Lys Thr Cys Leu 
    210                 215                 220                 


Trp Pro Lys Thr His Thr Leu Trp Ser Asn Gly Val Leu Glu Ser Gln 
225                 230                 235                 240 


Met Leu Ile Pro Lys Ser Tyr Ala Gly Pro Phe Ser Gln His Asn Tyr 
                245                 250                 255     


Arg Gln Gly Tyr Ala Thr Gln Thr Val Gly Pro Trp His Leu Gly Lys 
            260                 265                 270         


Leu Glu Ile Asp Phe Gly Glu Cys Pro Gly Thr Thr Val Thr Ile Gln 
        275                 280                 285             


Glu Asp Cys Asp His Arg Gly Pro Ser Leu Arg Thr Thr Thr Ala Ser 
    290                 295                 300                 


Gly Lys Leu Val Thr Gln Trp Cys Cys Arg Ser Cys Thr Met Pro Pro 
305                 310                 315                 320 


Leu Arg Phe Leu Gly Glu Asp Gly Cys Trp Tyr Gly Met Glu Ile Arg 
                325                 330                 335     


Pro Leu Ser Glu Lys Glu Glu Asn Met Val Lys Ser Gln Val Thr Ala 
            340                 345                 350         


His His His His His His His His His His 
        355                 360         


