                         SEQUENCE LISTING

<110>  Genentech, Inc.
 
<120>  DOSING FOR TREATMENT WITH ANTI-FCRH5/ANTI-CD3 BISPECIFIC 
       ANTIBODIES

<130>  50474-213WO5

<150>  US 63/239,859
<151>  2021-09-01

<150>  US 63/229,019
<151>  2021-08-03

<150>  US 63/116,597
<151>  2020-11-20

<150>  US 63/087,623
<151>  2020-10-05

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1

Arg Phe Gly Val His 
1               5   


<210>  2
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Val Ile Trp Arg Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Val Ser 
1               5                   10                  15      


<210>  3
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  3

His Tyr Tyr Gly Ser Ser Asp Tyr Ala Leu Asp Asn 
1               5                   10          


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Lys Ala Ser Gln Asp Val Arg Asn Leu Val Val 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5

Ser Gly Ser Tyr Arg Tyr Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Gln Gln His Tyr Ser Pro Pro Tyr Thr 
1               5                   


<210>  7
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7

Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Arg Phe 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Arg Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Val 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Asn His Tyr Tyr Gly Ser Ser Asp Tyr Ala Leu Asp Asn Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  8
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Arg Asn Leu 
            20                  25                  30          


Val Val Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ser Pro Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  9
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9

Ser Tyr Tyr Ile His 
1               5   


<210>  10
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Trp Ile Tyr Pro Glu Asn Asp Asn Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11

Asp Gly Tyr Ser Arg Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210>  12
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13

Trp Thr Ser Thr Arg Lys Ser 
1               5           


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Lys Gln Ser Phe Ile Leu Arg Thr 
1               5               


<210>  15
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Glu Asn Asp Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ser Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  16
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Thr Ser Thr Arg Lys Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Phe Ile Leu Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  17
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 
            20                  25                  30  


<210>  18
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly 
1               5                   10                  


<210>  19
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  19

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ser Asn 
            20                  25                  30          


<210>  20
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  21
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  22
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22

Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  23
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  23

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  25
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  25

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr 
            20                  25                  30  


<210>  26
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  27
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  27

Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr Leu Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  28
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  29
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  29

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys 
            20              


<210>  30
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  30

Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  31
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  31

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  32
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  32

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  33
<211>  5620
<212>  DNA
<213>  Homo sapiens

<400>  33
gcagtttcag aacccagcca gcctctctct tgctgcctag cctcctgccg gcctcatctt       60

cgcccagcca accccgcctg gagccctatg gccaactgcg agttcagccc ggtgtccggg      120

gacaaaccct gctgccggct ctctaggaga gcccaactct gtcttggcgt cagtatcctg      180

gtcctgatcc tcgtcgtggt gctcgcggtg gtcgtcccga ggtggcgcca gcagtggagc      240

ggtccgggca ccaccaagcg ctttcccgag accgtcctgg cgcgatgcgt caagtacact      300

gaaattcatc ctgagatgag acatgtagac tgccaaagtg tatgggatgc tttcaagggt      360

gcatttattt caaaacatcc ttgcaacatt actgaagaag actatcagcc actaatgaag      420

ttgggaactc agaccgtacc ttgcaacaag attcttcttt ggagcagaat aaaagatctg      480

gcccatcagt tcacacaggt ccagcgggac atgttcaccc tggaggacac gctgctaggc      540

taccttgctg atgacctcac atggtgtggt gaattcaaca cttccaaaat aaactatcaa      600

tcttgcccag actggagaaa ggactgcagc aacaaccctg tttcagtatt ctggaaaacg      660

gtttcccgca ggtttgcaga agctgcctgt gatgtggtcc atgtgatgct caatggatcc      720

cgcagtaaaa tctttgacaa aaacagcact tttgggagtg tggaagtcca taatttgcaa      780

ccagagaagg ttcagacact agaggcctgg gtgatacatg gtggaagaga agattccaga      840

gacttatgcc aggatcccac cataaaagag ctggaatcga ttataagcaa aaggaatatt      900

caattttcct gcaagaatat ctacagacct gacaagtttc ttcagtgtgt gaaaaatcct      960

gaggattcat cttgcacatc tgagatctga gccagtcgct gtggttgttt tagctccttg     1020

actccttgtg gtttatgtca tcatacatga ctcagcatac ctgctggtgc agagctgaag     1080

attttggagg gtcctccaca ataaggtcaa tgccagagac ggaagccttt ttccccaaag     1140

tcttaaaata acttatatca tcagcatacc tttattgtga tctatcaata gtcaagaaaa     1200

attattgtat aagattagaa tgaaaattgt atgttaagtt acttcacttt aattctcatg     1260

tgatcctttt atgttattta tatattggta acatcctttc tattgaaaaa tcaccacacc     1320

aaacctctct tattagaaca ggcaagtgaa gaaaagtgaa tgctcaagtt tttcagaaag     1380

cattacattt ccaaatgaat gaccttgttg catgatgtat ttttgtaccc ttcctacaga     1440

tagtcaaacc ataaacttca tggtcatggg tcatgttggt gaaaattatt ctgtaggata     1500

taagctaccc acgtacttgg tgctttaccc caacccttcc aacagtgctg tgaggttggt     1560

attatttcat tttttagatg agaaaatggg agctcagaga ggttatatat ttaagttggt     1620

gcaaaagtaa ttgcaagttt tgccaccgaa aggaatggca aaaccacaat tatttttgaa     1680

ccaacctaat aatttaccgt aagtcctaca tttagtatca agctagagac tgaatttgaa     1740

ctcaactctg tccaactcca aaattcatgt gctttttcct tctaggcctt tcataccaaa     1800

ctaatagtag tttatattct cttccaacaa atgcatattg gattaaattg actagaatgg     1860

aatctggaat atagttcttc tggatggctc caaaacacat gtttttcttc ccccgtcttc     1920

ctcctcctct tcatgctcag tgttttatat atgtagtata cagttaaaat atacttgttg     1980

ctggtactgg cagcttatat tttctctctt ttttcatgga ttaaccttgc ttgagggctt     2040

taacaattgt attacttttt caaagaacta agctttagct tcattgattt ttttctattt     2100

aattgggttt tgctcttctc tttagcattg gaaacataga aatgctttct gatttctttg     2160

ggtagattta cgtattcagc ttcttgagat ggaagtttag atcactgatc cttcagcttg     2220

ttttcttttt tgtatacata gattttagga cgatatattt tcccttgagt tctgctttag     2280

ctgcagctct tatgttttga tatgcctctc tttattatcc ttcagttaaa aatatctttc     2340

aattcattgt tatataaaaa tatgtgccta gtttttaaca tctggagatt ttctagtttt     2400

gaaaaaaaca taagccaggc atggtggctc acacctgtat ccccagcact ttgggaggcc     2460

gagacgggag gatcgcctga gctcaggagt ttttacacca gcctgggaat aacagtgaga     2520

cattatctcc aaaaaaatta cctgggtatg gtgttgtgca cctgtagtcc cagctactct     2580

ggagactgag gtgggaggat tgtttgagct tgggaggttg aggctgcagg gagctgtgat     2640

cacaccactg cactctggcc tgagtgacag attgagaccc tgtctcaata aaagcaaaaa     2700

taaagaaaat aaaccatatg tgttgaacaa aggattaata aattaatttg agactccttc     2760

agggaatgac cacaatttat tgaaaatagc ctaaatgttg gagtcaggca tttctggatt     2820

catattttga catcatgctg tcatcttgaa caaaatgcct aacctttctg aacttcaact     2880

tccttgccac tcaaataagg attacaaaac ttaaaatgtg gtaagtacta aagacgacag     2940

caaaaattga gtccagcaca gagcttccta aataagcaag cactcaacag agttggttcc     3000

tttcttcctc ccctgcttga caatccagtt tcccacagga gcctttgtag ctgtagccac     3060

catggtcagt ccagggattc ttcactagcc ccttctcccc tggcagacat ccttgtggga     3120

gtttagtctt ggctcgacat gaggatgggg gtttgggacc agttctgagt gagaatcaga     3180

cttgccccaa gttgccatta gctccccctg cagaatgtct tcagaatcgg ggcccggtca     3240

gtctcctggg tgacctgctg ttttcctctt aagatccttt ccactttggt tgctgctttc     3300

gggactcatc gagtccttgc tcaacaggat accccttgaa gtggctgcct gggccacatc     3360

cccttccaaa caagaaatca aaatattaga aatcaatttt tgaaatttcc cctaggaaga     3420

ctcatttgag tgttcaagtt cagagccagt ggagacctta ggggagggtg gtcacaagga     3480

ttttgcacag tgctttagag ggtcccaggg agccacagag gtggtgaggg gctgggtgct     3540

cttttctccg tgcatgacct tgtgtgtcta tcttcattac cacaatgcct catctctacc     3600

tcctttcccc ctgtagttcc aacgtgggta tctttgccat ctctggcccg aaggactttc     3660

tgacctacat gtataaatac cccctcacaa tatatattac ttttcctata agtgacttct     3720

ctactggatt actggttgct catacacctc atattttact cgtaaatcta ctactccctg     3780

tctgcctact ccattctcat ttgctgtaga aaattctctt accatcccaa ctttcaccca     3840

ccatcatgct tacccaaagg ctgtgggaat gacctgggcc ctaatgcccc ttttctaaat     3900

tcctaaggct caccattttc ctattgtaat ggttcttgac cttataatgt ttgaggcacc     3960

ttttcaaata tagtcctttg atttcagact gaatacttga aaggacacac acacacatac     4020

gtaagtgcat atgactgcat acacccacac acacacacgt gcctgtatac agtcatatga     4080

tacatacaca aacacacgca cacaagcctg catacatcat atgccaacag tggggatatg     4140

ttctgagaaa tgcatcatta gatgattttg tcattgtgtg aacatcatag agtgtactta     4200

cactaaccta gatggtctaa cctactacac acccaggcta catggtatca cctattcctc     4260

ctaggctaca agcctgtaca gcgtgtgtct gtactaaatg ctgtgggcaa ttttaacctg     4320

atggtaaatg tttgtgtatc taaacatatc taaacataga aaaggtacag taaacatgca     4380

gtattataat cttatgagac cgtcatcata tatgtggtcc actgtttggg ccatcattgg     4440

ctgaaaagtg gttatgcgac acatgactgt atatatactt tcctgttaca acaacagtgt     4500

ctctcaatcc acagtaattg cagcatccag taggtcttac tttagccctg agtcaccatt     4560

tgtgtcaacg tgtttagtgc catgtccacg tctctcatgt aactggcaga gctatcaaat     4620

attttggcaa aacacattgt ttctttggct ttgccttggt aactttctgt gccttttgta     4680

gctcttgttt ggaagaagct caacccatgt ctgcacactg tgatacaagg gggacagcat     4740

cgacatcgac ttacttcttg gtgccttatt cctccttaga acaattccta aatctgtaac     4800

ttaagtttct caggaagatt ccatactgca cagaaaactg cttttgtggg tttttaaaag     4860

gcaagttgtt atatgtgctg gatagttttt aagtatgaca taaaaattgt ataaagtaaa     4920

atattaaaat acacctagaa tactgtataa ctttaagtca ttttatcaac acattgctaa     4980

tccagatatt ttcccgcagt ttttctttga ataacagagc aattaattta cttttactat     5040

gaagagtcat cattttagta tgtattttaa gcaatccacc aagaactcag taggcagctg     5100

agaggtgctg cccagagaag tggtgattag cttggcctta gctcacccac acaaagcaca     5160

acaggctttg aactattccc taacggggca tttattcttt tttttttttt tttttgggag     5220

acggagtctc gctgtcgccc aggctagagt gcagtggcgc gatctcggct cactgcaggc     5280

tccaccccct ggggttcacg ccattctcct gcctcagcct cccaagtagc tgggactgca     5340

ggcgcccgcc atctcgcccg gctaattttt tgtattttta gtagagacgg ggtttcaccg     5400

tgttagccag gatagggcat ttattcttga acttgattca gagaggcaca cattaccatt     5460

ctctaatcag aatgcaagta gcgcaaggcg gtggaaacta tggaattcgg aggcaggtga     5520

tgcattgggc gagtttatta acatctgtga ctctctagtt tgaaatttat ttgtaacaga     5580

caaaaatgaa ttaaacaaac aataaaagta taataaagaa                           5620


<210>  34
<211>  300
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ala Asn Cys Glu Phe Ser Pro Val Ser Gly Asp Lys Pro Cys Cys 
1               5                   10                  15      


Arg Leu Ser Arg Arg Ala Gln Leu Cys Leu Gly Val Ser Ile Leu Val 
            20                  25                  30          


Leu Ile Leu Val Val Val Leu Ala Val Val Val Pro Arg Trp Arg Gln 
        35                  40                  45              


Gln Trp Ser Gly Pro Gly Thr Thr Lys Arg Phe Pro Glu Thr Val Leu 
    50                  55                  60                  


Ala Arg Cys Val Lys Tyr Thr Glu Ile His Pro Glu Met Arg His Val 
65                  70                  75                  80  


Asp Cys Gln Ser Val Trp Asp Ala Phe Lys Gly Ala Phe Ile Ser Lys 
                85                  90                  95      


His Pro Cys Asn Ile Thr Glu Glu Asp Tyr Gln Pro Leu Met Lys Leu 
            100                 105                 110         


Gly Thr Gln Thr Val Pro Cys Asn Lys Ile Leu Leu Trp Ser Arg Ile 
        115                 120                 125             


Lys Asp Leu Ala His Gln Phe Thr Gln Val Gln Arg Asp Met Phe Thr 
    130                 135                 140                 


Leu Glu Asp Thr Leu Leu Gly Tyr Leu Ala Asp Asp Leu Thr Trp Cys 
145                 150                 155                 160 


Gly Glu Phe Asn Thr Ser Lys Ile Asn Tyr Gln Ser Cys Pro Asp Trp 
                165                 170                 175     


Arg Lys Asp Cys Ser Asn Asn Pro Val Ser Val Phe Trp Lys Thr Val 
            180                 185                 190         


Ser Arg Arg Phe Ala Glu Ala Ala Cys Asp Val Val His Val Met Leu 
        195                 200                 205             


Asn Gly Ser Arg Ser Lys Ile Phe Asp Lys Asn Ser Thr Phe Gly Ser 
    210                 215                 220                 


Val Glu Val His Asn Leu Gln Pro Glu Lys Val Gln Thr Leu Glu Ala 
225                 230                 235                 240 


Trp Val Ile His Gly Gly Arg Glu Asp Ser Arg Asp Leu Cys Gln Asp 
                245                 250                 255     


Pro Thr Ile Lys Glu Leu Glu Ser Ile Ile Ser Lys Arg Asn Ile Gln 
            260                 265                 270         


Phe Ser Cys Lys Asn Ile Tyr Arg Pro Asp Lys Phe Leu Gln Cys Val 
        275                 280                 285             


Lys Asn Pro Glu Asp Ser Ser Cys Thr Ser Glu Ile 
    290                 295                 300 


<210>  35
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  35

Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Arg Phe 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Arg Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Val 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Asn His Tyr Tyr Gly Ser Ser Asp Tyr Ala Leu Asp Asn Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  36
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  36

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Arg Asn Leu 
            20                  25                  30          


Val Val Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ser Pro Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  37
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  37

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Glu Asn Asp Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ser Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser 
        355                 360                 365             


Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  38
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  38

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Thr Ser Thr Arg Lys Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Phe Ile Leu Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


