                               SEQUENCE LISTING

<110> ALEXION PHARMACEUTICALS, INC.
 
<120> METHODS OF TREATING DERMATOMYOSITIS

<130> 0643WO

<140> PCT/US2021/053540
<141> 2021-10-05

<150> 63/087,577
<151> 2020-10-05

<160> 12    

<170> PatentIn version 3.5

<210> 1
<211> 264
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Pro Val Ser Asn Tyr 
            20                  25                  30          


Ala Ala Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Gln Lys Thr Ala Thr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Phe Arg Val Val Ala Pro Lys Thr Gln Tyr Asp Tyr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ala 
        115                 120                 125             


Gly Gly Gly Gly Ala Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
    130                 135                 140                 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
145                 150                 155                 160 


Ala Ala Ser Gly Arg Ala His Ser Asp Tyr Ala Met Ala Trp Phe Arg 
                165                 170                 175     


Gln Ala Pro Gly Gln Glu Arg Glu Phe Val Ala Gly Ile Gly Trp Ser 
            180                 185                 190         


Gly Gly Asp Thr Leu Tyr Ala Asp Ser Val Arg Gly Arg Phe Thr Asn 
        195                 200                 205             


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
    210                 215                 220                 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Arg Gln Gly Gln 
225                 230                 235                 240 


Tyr Ile Tyr Ser Ser Met Arg Ser Asp Ser Tyr Asp Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Leu Val Thr Val Ser Ser 
            260                 


<210> 2
<211> 792
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 2
gaggtgcagc tggttgaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgctg cttctggcag acccgtgtct aattacgccg ctgcctggtt tagacaggcc      120

cctggcaaag agagagagtt cgtcagcgcc atcaactggc agaaaaccgc cacatacgcc      180

gacagcgtga agggcagatt caccatcagc cgggacaacg ccaagaacag cctgtacctg      240

cagatgaact ccctgagagc cgaggacacc gccgtgtatt attgtgccgc cgtgtttaga      300

gtggtggccc ctaagacaca gtacgactac gattactggg gccagggcac cctggttaca      360

gtttctagtg gcggaggcgg agctggtggt ggcggagcag gaggcggagg atctgaagtt      420

caacttgtcg agagtggcgg cggactggtt caaccaggcg gaagtcttag actgagctgt      480

gctgctagcg gcagagccca ctctgattac gctatggcat ggttcaggca ggccccagga      540

caagaaaggg aatttgtggc cggaatcggt tggagcggcg gagatacact gtacgccgat      600

tctgtgcgcg gcaggttcac caactccaga gacaacagca agaacacgct ctatctccag      660

atgaatagcc tgcgggccga agatacagcc gtgtactact gtgctgcccg gcagggccag      720

tacatctaca gcagcatgag aagcgacagc tatgactatt ggggacaggg aaccctcgtg      780

accgtgtcct ct                                                          792


<210> 3
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Pro Val Ser Asn Tyr 
            20                  25                  30          


Ala Ala Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Gln Lys Thr Ala Thr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Phe Arg Val Val Ala Pro Lys Thr Gln Tyr Asp Tyr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210> 4
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Gly Arg Pro Val Ser Asn Tyr Ala 
1               5               


<210> 5
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Ile Asn Trp Gln Lys Thr Ala Thr 
1               5               


<210> 6
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Ala Ala Val Phe Arg Val Val Ala Pro Lys Thr Gln Tyr Asp Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210> 7
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala His Ser Asp Tyr 
            20                  25                  30          


Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Gln Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ser Gly Gly Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Asn Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Gln Gly Gln Tyr Ile Tyr Ser Ser Met Arg Ser Asp Ser 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 8
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Gly Arg Ala His Ser Asp Tyr Ala Met Ala 
1               5                   10  


<210> 9
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Gly Ile Gly Trp Ser Gly Gly Asp Thr Leu Tyr Ala Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210> 10
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Ala Ala Arg Gln Gly Gln Tyr Ile Tyr Ser Ser Met Arg Ser Asp Ser 
1               5                   10                  15      


Tyr Asp Tyr 
            


<210> 11
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 12
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 12
His His His His His His 
1               5       


