                         SEQUENCE LISTING

<110>  UCL BUSINESS LTD
       UNIVERSITT ZU KLN
 
<120>  Therapeutic treatment

<130>  008123580

<140>  PCT/EP2021/077939
<141>  2021-10-08

<150>  GB 2016058.6
<151>  2020-10-09

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  1

Ile Thr Gln Gln Asp Leu Ala Pro Gln Gln Arg Ala Ala Pro Gln Gln 
1               5                   10                  15      


Lys Arg Ser Ser Pro Ser Glu Gly Leu Cys Pro Pro Gly His His Ile 
            20                  25                  30          


Ser Glu Asp Gly Arg Asp Cys Ile Ser Cys Lys Tyr Gly Gln Asp Tyr 
        35                  40                  45              


Ser Thr His Trp Asn Asp Leu Leu Phe Cys Leu Arg Cys Thr Arg Cys 
    50                  55                  60                  


Asp Ser Gly Glu Val Glu Leu Ser Pro Cys Thr Thr Thr Arg Asn Thr 
65                  70                  75                  80  


Val Cys Gln Cys Glu Glu Gly Thr Phe Arg Glu Glu Asp Ser Pro Glu 
                85                  90                  95      


Met Cys Arg Lys Cys Arg Thr Gly Cys Pro Arg Gly Met Val Lys Val 
            100                 105                 110         


Gly Asp Cys Thr Pro Trp Ser Asp Ile Glu Cys Val His Lys Glu Ser 
        115                 120                 125             


Gly Thr Lys His Ser Gly Glu Val Pro Ala Val Glu Glu Thr Val Thr 
    130                 135                 140                 


Ser Ser Pro Gly Thr Pro Ala Ser Asp Lys Thr His Thr Cys Pro Pro 
145                 150                 155                 160 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                165                 170                 175     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            180                 185                 190         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        195                 200                 205             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    210                 215                 220                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
225                 230                 235                 240 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                245                 250                 255     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            260                 265                 270         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        275                 280                 285             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    290                 295                 300                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
305                 310                 315                 320 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                325                 330                 335     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            340                 345                 350         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        355                 360                 365             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375                 


<210>  2
<211>  434
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  2

Met Glu Gln Arg Gly Gln Asn Ala Pro Ala Ala Ser Gly Ala Arg Lys 
1               5                   10                  15      


Arg His Gly Pro Gly Pro Arg Glu Ala Arg Gly Ala Arg Pro Gly Pro 
            20                  25                  30          


Arg Val Pro Lys Thr Leu Val Leu Val Val Ala Ala Val Leu Leu Leu 
        35                  40                  45              


Val Ser Ala Glu Ser Ala Leu Ile Thr Gln Gln Asp Leu Ala Pro Gln 
    50                  55                  60                  


Gln Arg Ala Ala Pro Gln Gln Lys Arg Ser Ser Pro Ser Glu Gly Leu 
65                  70                  75                  80  


Cys Pro Pro Gly His His Ile Ser Glu Asp Gly Arg Asp Cys Ile Ser 
                85                  90                  95      


Cys Lys Tyr Gly Gln Asp Tyr Ser Thr His Trp Asn Asp Leu Leu Phe 
            100                 105                 110         


Cys Leu Arg Cys Thr Arg Cys Asp Ser Gly Glu Val Glu Leu Ser Pro 
        115                 120                 125             


Cys Thr Thr Thr Arg Asn Thr Val Cys Gln Cys Glu Glu Gly Thr Phe 
    130                 135                 140                 


Arg Glu Glu Asp Ser Pro Glu Met Cys Arg Lys Cys Arg Thr Gly Cys 
145                 150                 155                 160 


Pro Arg Gly Met Val Lys Val Gly Asp Cys Thr Pro Trp Ser Asp Ile 
                165                 170                 175     


Glu Cys Val His Lys Glu Ser Gly Thr Lys His Ser Gly Glu Val Pro 
            180                 185                 190         


Ala Val Glu Glu Thr Val Thr Ser Ser Pro Gly Thr Pro Ala Ser Asp 
        195                 200                 205             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    210                 215                 220                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
225                 230                 235                 240 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                245                 250                 255     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            260                 265                 270         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        275                 280                 285             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    290                 295                 300                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
305                 310                 315                 320 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                325                 330                 335     


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
            340                 345                 350         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        355                 360                 365             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    370                 375                 380                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
385                 390                 395                 400 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                405                 410                 415     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            420                 425                 430         


Gly Lys 
        


<210>  3
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  3

Met Gly Ser Thr Ala Ile Leu Gly Leu Leu Leu Ala Val Leu Gln Gly 
1               5                   10                  15      


Val Cys Ala Ile Thr Gln Gln Asp Leu Ala Pro Gln Gln Arg Ala Ala 
            20                  25                  30          


Pro Gln Gln Lys Arg Ser Ser Pro Ser Glu Gly Leu Cys Pro Pro Gly 
        35                  40                  45              


His His Ile Ser Glu Asp Gly Arg Asp Cys Ile Ser Cys Lys Tyr Gly 
    50                  55                  60                  


Gln Asp Tyr Ser Thr His Trp Asn Asp Leu Leu Phe Cys Leu Arg Cys 
65                  70                  75                  80  


Thr Arg Cys Asp Ser Gly Glu Val Glu Leu Ser Pro Cys Thr Thr Thr 
                85                  90                  95      


Arg Asn Thr Val Cys Gln Cys Glu Glu Gly Thr Phe Arg Glu Glu Asp 
            100                 105                 110         


Ser Pro Glu Met Cys Arg Lys Cys Arg Thr Gly Cys Pro Arg Gly Met 
        115                 120                 125             


Val Lys Val Gly Asp Cys Thr Pro Trp Ser Asp Ile Glu Cys Val His 
    130                 135                 140                 


Lys Glu Ser Gly Thr Lys His Ser Gly Glu Val Pro Ala Val Glu Glu 
145                 150                 155                 160 


Thr Val Thr Ser Ser Pro Gly Thr Pro Ala Ser Asp Lys Thr His Thr 
                165                 170                 175     


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
            180                 185                 190         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        195                 200                 205             


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
    210                 215                 220                 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
225                 230                 235                 240 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
                245                 250                 255     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            260                 265                 270         


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
        275                 280                 285             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    290                 295                 300                 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
305                 310                 315                 320 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                325                 330                 335     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            340                 345                 350         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        355                 360                 365             


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    370                 375                 380                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
385                 390                 395             


<210>  4
<211>  1143
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  4
attactcagc aagatctggc ccctcagcaa agggccgctc cacaacagaa gagaagcagc       60

ccaagcgagg gactctgccc tcccggccac cacattagcg aggacggcag agattgcatc      120

agctgtaagt acggccaaga ttacagcaca cactggaatg atctgctgtt ctgtctgagg      180

tgtacaaggt gcgactccgg cgaagtcgaa ctgagccctt gcactactac taggaacact      240

gtctgccagt gcgaggaggg cacttttagg gaggaggata gcccagagat gtgtaggaag      300

tgtaggactg gctgccctag gggcatggtg aaggtgggcg actgtactcc atggagcgac      360

attgagtgcg tgcataagga gagcggcact aagcacagcg gcgaagtgcc agccgtggaa      420

gagactgtga ctagctcccc cggcacacca gccagcgaca agacacacac ttgtcctcct      480

tgcccagctc cagaactgct cggaggacca agcgtgtttc tgttccctcc aaagccaaag      540

gacacactca tgatctctag gactccagag gtcacttgcg tggtcgtgga tgtcagccac      600

gaagatccag aggtgaagtt taattggtac gtggatggcg tggaggtcca caacgccaag      660

acaaagccta gggaggagca gtacaatagc acttataggg tggtcagcgt gctgacagtg      720

ctgcaccaag attggctcaa cggcaaggag tacaagtgca aggtgagcaa caaggccctc      780

ccagccccta tcgagaagac aatctccaag gccaagggcc aaccaaggga gcctcaagtg      840

tatacactcc ctcctagcag agacgagctc actaagaatc aagtgtctct gacttgtctg      900

gtgaagggct tttacccaag cgacatcgcc gtggagtggg agagcaacgg ccaaccagag      960

aacaactaca agacaactcc tccagtgctg gactccgacg gcagcttctt cctctacagc     1020

aagctgactg tggataagtc cagatggcag caaggcaacg tcttcagctg tagcgtgatg     1080

cacgaggccc tccacaacca ctacacacag aagtctctgt ctctgagccc cggcaaataa     1140

tag                                                                   1143


<210>  5
<211>  1200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  5
atggggtcaa ccgccatcct tggcctcctc ctggctgttc tccaaggagt ctgtgccatt       60

actcagcaag atctggcccc tcagcaaagg gccgctccac aacagaagag aagcagccca      120

agcgagggac tctgccctcc cggccaccac attagcgagg acggcagaga ttgcatcagc      180

tgtaagtacg gccaagatta cagcacacac tggaatgatc tgctgttctg tctgaggtgt      240

acaaggtgcg actccggcga agtcgaactg agcccttgca ctactactag gaacactgtc      300

tgccagtgcg aggagggcac ttttagggag gaggatagcc cagagatgtg taggaagtgt      360

aggactggct gccctagggg catggtgaag gtgggcgact gtactccatg gagcgacatt      420

gagtgcgtgc ataaggagag cggcactaag cacagcggcg aagtgccagc cgtggaagag      480

actgtgacta gctcccccgg cacaccagcc agcgacaaga cacacacttg tcctccttgc      540

ccagctccag aactgctcgg aggaccaagc gtgtttctgt tccctccaaa gccaaaggac      600

acactcatga tctctaggac tccagaggtc acttgcgtgg tcgtggatgt cagccacgaa      660

gatccagagg tgaagtttaa ttggtacgtg gatggcgtgg aggtccacaa cgccaagaca      720

aagcctaggg aggagcagta caatagcact tatagggtgg tcagcgtgct gacagtgctg      780

caccaagatt ggctcaacgg caaggagtac aagtgcaagg tgagcaacaa ggccctccca      840

gcccctatcg agaagacaat ctccaaggcc aagggccaac caagggagcc tcaagtgtat      900

acactccctc ctagcagaga cgagctcact aagaatcaag tgtctctgac ttgtctggtg      960

aagggctttt acccaagcga catcgccgtg gagtgggaga gcaacggcca accagagaac     1020

aactacaaga caactcctcc agtgctggac tccgacggca gcttcttcct ctacagcaag     1080

ctgactgtgg ataagtccag atggcagcaa ggcaacgtct tcagctgtag cgtgatgcac     1140

gaggccctcc acaaccacta cacacagaag tctctgtctc tgagccccgg caaataatag     1200


<210>  6
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  6

Met Glu Gln Arg Gly Gln Asn Ala Pro Ala Ala Ser Gly Ala Arg Lys 
1               5                   10                  15      


Arg His Gly Pro Gly Pro Arg Glu Ala Arg Gly Ala Arg Pro Gly Pro 
            20                  25                  30          


Arg Val Pro Lys Thr Leu Val Leu Val Val Ala Ala Val Leu Leu Leu 
        35                  40                  45              


Val Ser Ala Glu Ser Ala Leu Ile Thr Gln Gln Asp Leu Ala Pro Gln 
    50                  55                  60                  


Gln Arg Ala Ala Pro Gln Gln Lys Arg Ser Ser Pro Ser Glu Gly Leu 
65                  70                  75                  80  


Cys Pro Pro Gly His His Ile Ser Glu Asp Gly Arg Asp Cys Ile Ser 
                85                  90                  95      


Cys Lys Tyr Gly Gln Asp Tyr Ser Thr His Trp Asn Asp Leu Leu Phe 
            100                 105                 110         


Cys Leu Arg Cys Thr Arg Cys Asp Ser Gly Glu Val Glu Leu Ser Pro 
        115                 120                 125             


Cys Thr Thr Thr Arg Asn Thr Val Cys Gln Cys Glu Glu Gly Thr Phe 
    130                 135                 140                 


Arg Glu Glu Asp Ser Pro Glu Met Cys Arg Lys Cys Arg Thr Gly Cys 
145                 150                 155                 160 


Pro Arg Gly Met Val Lys Val Gly Asp Cys Thr Pro Trp Ser Asp Ile 
                165                 170                 175     


Glu Cys Val His Lys Glu Ser Gly Thr Lys His Ser Gly Glu Val Pro 
            180                 185                 190         


Ala Val Glu Glu Thr Val Thr Ser Ser Pro Gly Thr Pro Ala Ser Pro 
        195                 200                 205             


Cys Ser Leu Ser Gly Ile Ile Ile Gly Val Thr Val Ala Ala Val Val 
    210                 215                 220                 


Leu Ile Val Ala Val Phe Val Cys Lys Ser Leu Leu Trp Lys Lys Val 
225                 230                 235                 240 


Leu Pro Tyr Leu Lys Gly Ile Cys Ser Gly Gly Gly Gly Asp Pro Glu 
                245                 250                 255     


Arg Val Asp Arg Ser Ser Gln Arg Pro Gly Ala Glu Asp Asn Val Leu 
            260                 265                 270         


Asn Glu Ile Val Ser Ile Leu Gln Pro Thr Gln Val Pro Glu Gln Glu 
        275                 280                 285             


Met Glu Val Gln Glu Pro Ala Glu Pro Thr Gly Val Asn Met Leu Ser 
    290                 295                 300                 


Pro Gly Glu Ser Glu His Leu Leu Glu Pro Ala Glu Ala Glu Arg Ser 
305                 310                 315                 320 


Gln Arg Arg Arg Leu Leu Val Pro Ala Asn Glu Gly Asp Pro Thr Glu 
                325                 330                 335     


Thr Leu Arg Gln Cys Phe Asp Asp Phe Ala Asp Leu Val Pro Phe Asp 
            340                 345                 350         


Ser Trp Glu Pro Leu Met Arg Lys Leu Gly Leu Met Asp Asn Glu Ile 
        355                 360                 365             


Lys Val Ala Lys Ala Glu Ala Ala Gly His Arg Asp Thr Leu Tyr Thr 
    370                 375                 380                 


Met Leu Ile Lys Trp Val Asn Lys Thr Gly Arg Asp Ala Ser Val His 
385                 390                 395                 400 


Thr Leu Leu Asp Ala Leu Glu Thr Leu Gly Glu Arg Leu Ala Lys Gln 
                405                 410                 415     


Lys Ile Glu Asp His Leu Leu Ser Ser Gly Lys Phe Met Tyr Leu Glu 
            420                 425                 430         


Gly Asn Ala Asp Ser Ala Met Ser 
        435                 440 


<210>  7
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  7

Met Glu Gln Arg Gly Gln Asn Ala Pro Ala Ala Ser Gly Ala Arg Lys 
1               5                   10                  15      


Arg His Gly Pro Gly Pro Arg Glu Ala Arg Gly Ala Arg Pro Gly Pro 
            20                  25                  30          


Arg Val Pro Lys Thr Leu Val Leu Val Val Ala Ala Val Leu Leu Leu 
        35                  40                  45              


Val Ser Ala Glu Ser Ala Leu Ile Thr Gln Gln Asp Leu Ala Pro Gln 
    50                  55                  60                  


Gln Arg Ala Ala Pro Gln Gln Lys Arg Ser Ser Pro Ser Glu Gly Leu 
65                  70                  75                  80  


Cys Pro Pro Gly His His Ile Ser Glu Asp Gly Arg Asp Cys Ile Ser 
                85                  90                  95      


Cys Lys Tyr Gly Gln Asp Tyr Ser Thr His Trp Asn Asp Leu Leu Phe 
            100                 105                 110         


Cys Leu Arg Cys Thr Arg Cys Asp Ser Gly Glu Val Glu Leu Ser Pro 
        115                 120                 125             


Cys Thr Thr Thr Arg Asn Thr Val Cys Gln Cys Glu Glu Gly Thr Phe 
    130                 135                 140                 


Arg Glu Glu Asp Ser Pro Glu Met Cys Arg Lys Cys Arg Thr Gly Cys 
145                 150                 155                 160 


Pro Arg Gly Met Val Lys Val Gly Asp Cys Thr Pro Trp Ser Asp Ile 
                165                 170                 175     


Glu Cys Val His Lys Glu Ser Gly Ile Ile Ile Gly Val Thr Val Ala 
            180                 185                 190         


Ala Val Val Leu Ile Val Ala Val Phe Val Cys Lys Ser Leu Leu Trp 
        195                 200                 205             


Lys Lys Val Leu Pro Tyr Leu Lys Gly Ile Cys Ser Gly Gly Gly Gly 
    210                 215                 220                 


Asp Pro Glu Arg Val Asp Arg Ser Ser Gln Arg Pro Gly Ala Glu Asp 
225                 230                 235                 240 


Asn Val Leu Asn Glu Ile Val Ser Ile Leu Gln Pro Thr Gln Val Pro 
                245                 250                 255     


Glu Gln Glu Met Glu Val Gln Glu Pro Ala Glu Pro Thr Gly Val Asn 
            260                 265                 270         


Met Leu Ser Pro Gly Glu Ser Glu His Leu Leu Glu Pro Ala Glu Ala 
        275                 280                 285             


Glu Arg Ser Gln Arg Arg Arg Leu Leu Val Pro Ala Asn Glu Gly Asp 
    290                 295                 300                 


Pro Thr Glu Thr Leu Arg Gln Cys Phe Asp Asp Phe Ala Asp Leu Val 
305                 310                 315                 320 


Pro Phe Asp Ser Trp Glu Pro Leu Met Arg Lys Leu Gly Leu Met Asp 
                325                 330                 335     


Asn Glu Ile Lys Val Ala Lys Ala Glu Ala Ala Gly His Arg Asp Thr 
            340                 345                 350         


Leu Tyr Thr Met Leu Ile Lys Trp Val Asn Lys Thr Gly Arg Asp Ala 
        355                 360                 365             


Ser Val His Thr Leu Leu Asp Ala Leu Glu Thr Leu Gly Glu Arg Leu 
    370                 375                 380                 


Ala Lys Gln Lys Ile Glu Asp His Leu Leu Ser Ser Gly Lys Phe Met 
385                 390                 395                 400 


Tyr Leu Glu Gly Asn Ala Asp Ser Ala Met Ser 
                405                 410     


<210>  8
<211>  435
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  8

Met Glu Gln Arg Gly Gln Asn Ala Pro Ala Ala Ser Gly Ala Arg Lys 
1               5                   10                  15      


Arg His Gly Pro Gly Pro Arg Glu Ala Arg Gly Ala Arg Pro Gly Pro 
            20                  25                  30          


Arg Val Pro Lys Thr Leu Val Leu Val Val Ala Ala Val Leu Leu Leu 
        35                  40                  45              


Val Ser Ala Glu Ser Ala Leu Ile Thr Gln Gln Asp Leu Ala Pro Gln 
    50                  55                  60                  


Gln Arg Ala Ala Pro Gln Gln Lys Arg Ser Ser Pro Ser Glu Gly Leu 
65                  70                  75                  80  


Cys Pro Pro Gly His His Ile Ser Glu Asp Gly Arg Asp Cys Ile Ser 
                85                  90                  95      


Cys Lys Tyr Gly Gln Asp Tyr Ser Thr His Trp Asn Asp Leu Leu Phe 
            100                 105                 110         


Cys Leu Arg Cys Thr Arg Cys Asp Ser Gly Glu Val Glu Leu Ser Pro 
        115                 120                 125             


Cys Thr Thr Thr Arg Asn Thr Val Cys Gln Cys Glu Glu Gly Thr Phe 
    130                 135                 140                 


Arg Glu Glu Asp Ser Pro Glu Met Cys Arg Lys Cys Arg Thr Gly Cys 
145                 150                 155                 160 


Pro Arg Gly Met Val Lys Val Gly Asp Cys Thr Pro Trp Ser Asp Ile 
                165                 170                 175     


Glu Cys Val His Lys Glu Ser Gly Thr Lys His Ser Gly Glu Val Pro 
            180                 185                 190         


Ala Val Glu Glu Thr Val Thr Ser Ser Pro Gly Thr Pro Ala Ser Cys 
        195                 200                 205             


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
    210                 215                 220                 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
225                 230                 235                 240 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                245                 250                 255     


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            260                 265                 270         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
        275                 280                 285             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    290                 295                 300                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
305                 310                 315                 320 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                325                 330                 335     


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
            340                 345                 350         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        355                 360                 365             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    370                 375                 380                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
385                 390                 395                 400 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                405                 410                 415     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            420                 425                 430         


Pro Gly Lys 
        435 


<210>  9
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  9

Met Gly Ser Thr Ala Ile Leu Gly Leu Leu Leu Ala Val Leu Gln Gly 
1               5                   10                  15      


Val Cys Ala Ile Thr Gln Gln Asp Leu Ala Pro Gln Gln Arg Ala Ala 
            20                  25                  30          


Pro Gln Gln Lys Arg Ser Ser Pro Ser Glu Gly Leu Cys Pro Pro Gly 
        35                  40                  45              


His His Ile Ser Glu Asp Gly Arg Asp Cys Ile Ser Cys Lys Tyr Gly 
    50                  55                  60                  


Gln Asp Tyr Ser Thr His Trp Asn Asp Leu Leu Phe Cys Leu Arg Cys 
65                  70                  75                  80  


Thr Arg Cys Asp Ser Gly Glu Val Glu Leu Ser Pro Cys Thr Thr Thr 
                85                  90                  95      


Arg Asn Thr Val Cys Gln Cys Glu Glu Gly Thr Phe Arg Glu Glu Asp 
            100                 105                 110         


Ser Pro Glu Met Cys Arg Lys Cys Arg Thr Gly Cys Pro Arg Gly Met 
        115                 120                 125             


Val Lys Val Gly Asp Cys Thr Pro Trp Ser Asp Ile Glu Cys Val His 
    130                 135                 140                 


Lys Glu Ser Gly Thr Lys His Ser Gly Glu Val Pro Ala Val Glu Glu 
145                 150                 155                 160 


Thr Val Thr Ser Ser Pro Gly Thr Pro Ala Ser Ser Asp Lys Thr His 
                165                 170                 175     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
            180                 185                 190         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        195                 200                 205             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    210                 215                 220                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
225                 230                 235                 240 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                245                 250                 255     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            260                 265                 270         


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        275                 280                 285             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    290                 295                 300                 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
305                 310                 315                 320 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                325                 330                 335     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            340                 345                 350         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        355                 360                 365             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    370                 375                 380                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
385                 390                 395                 


<210>  10
<211>  1203
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  10
atgggctcca ccgccatcct gggcctgctg ctggccgtgc tgcagggcgt gtgcgccatt       60

actcagcaag atctggcccc tcagcaaagg gccgctccac aacagaagag aagcagccca      120

agcgagggac tctgccctcc cggccaccac attagcgagg acggcagaga ttgcatcagc      180

tgtaagtacg gccaagatta cagcacacac tggaatgatc tgctgttctg tctgaggtgt      240

acaaggtgcg actccggcga agtcgaactg agcccttgca ctactactag gaacactgtc      300

tgccagtgcg aggagggcac ttttagggag gaggatagcc cagagatgtg taggaagtgt      360

aggactggct gccctagggg catggtgaag gtgggcgact gtactccatg gagcgacatt      420

gagtgcgtgc ataaggagag cggcactaag cacagcggcg aagtgccagc cgtggaagag      480

actgtgacta gctcccccgg cacaccagcc agctccgaca agacacacac ttgtcctcct      540

tgcccagctc cagaactgct cggaggacca agcgtgtttc tgttccctcc aaagccaaag      600

gacacactca tgatctctag gactccagag gtcacttgcg tggtcgtgga tgtcagccac      660

gaagatccag aggtgaagtt taattggtac gtggatggcg tggaggtcca caacgccaag      720

acaaagccta gggaggagca gtacaatagc acttataggg tggtcagcgt gctgacagtg      780

ctgcaccaag attggctcaa cggcaaggag tacaagtgca aggtgagcaa caaggccctc      840

ccagccccta tcgagaagac aatctccaag gccaagggcc aaccaaggga gcctcaagtg      900

tatacactcc ctcctagcag agacgagctc actaagaatc aagtgtctct gacttgtctg      960

gtgaagggct tttacccaag cgacatcgcc gtggagtggg agagcaacgg ccaaccagag     1020

aacaactaca agacaactcc tccagtgctg gactccgacg gcagcttctt cctctacagc     1080

aagctgactg tggataagtc cagatggcag caaggcaacg tcttcagctg tagcgtgatg     1140

cacgaggccc tccacaacca ctacacacag aagtctctgt ctctgagccc cggcaaataa     1200

tag                                                                   1203


<210>  11
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  11

Ile Thr Gln Gln Asp Leu Ala Pro Gln Gln Arg Ala Ala Pro Gln Gln 
1               5                   10                  15      


Lys Arg Ser Ser Pro Ser Glu Gly Leu Cys Pro Pro Gly His His Ile 
            20                  25                  30          


Ser Glu Asp Gly Arg Asp Cys Ile Ser Cys Lys Tyr Gly Gln Asp Tyr 
        35                  40                  45              


Ser Thr His Trp Asn Asp Leu Leu Phe Cys Leu Arg Cys Thr Arg Cys 
    50                  55                  60                  


Asp Ser Gly Glu Val Glu Leu Ser Pro Cys Thr Thr Thr Arg Asn Thr 
65                  70                  75                  80  


Val Cys Gln Cys Glu Glu Gly Thr Phe Arg Glu Glu Asp Ser Pro Glu 
                85                  90                  95      


Met Cys Arg Lys Cys Arg Thr Gly Cys Pro Arg Gly Met Val Lys Val 
            100                 105                 110         


Gly Asp Cys Thr Pro Trp Ser Asp Ile Glu Cys Val His Lys Glu Ser 
        115                 120                 125             


Gly Thr Lys His Ser Gly Glu Val Pro Ala Val Glu Glu Thr Val Thr 
    130                 135                 140                 


Ser Ser Pro Gly Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
145                 150                 155                 160 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                165                 170                 175     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            180                 185                 190         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        195                 200                 205             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    210                 215                 220                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
225                 230                 235                 240 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                245                 250                 255     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            260                 265                 270         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        275                 280                 285             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    290                 295                 300                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
305                 310                 315                 320 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                325                 330                 335     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            340                 345                 350         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        355                 360                 365             


Leu Ser Pro Gly Lys 
    370             


<210>  12
<211>  1125
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  12
attactcagc aagatctggc ccctcagcaa agggccgctc cacaacagaa gagaagcagc       60

ccaagcgagg gactctgccc tcccggccac cacattagcg aggacggcag agattgcatc      120

agctgtaagt acggccaaga ttacagcaca cactggaatg atctgctgtt ctgtctgagg      180

tgtacaaggt gcgactccgg cgaagtcgaa ctgagccctt gcactactac taggaacact      240

gtctgccagt gcgaggaggg cacttttagg gaggaggata gcccagagat gtgtaggaag      300

tgtaggactg gctgccctag gggcatggtg aaggtgggcg actgtactcc atggagcgac      360

attgagtgcg tgcataagga gagcggcact aagcacagcg gcgaagtgcc agccgtggaa      420

gagactgtga ctagctcccc cggcacacac acttgtcctc cttgcccagc tccagaactg      480

ctcggaggac caagcgtgtt tctgttccct ccaaagccaa aggacacact catgatctct      540

aggactccag aggtcacttg cgtggtcgtg gatgtcagcc acgaagatcc agaggtgaag      600

tttaattggt acgtggatgg cgtggaggtc cacaacgcca agacaaagcc tagggaggag      660

cagtacaata gcacttatag ggtggtcagc gtgctgacag tgctgcacca agattggctc      720

aacggcaagg agtacaagtg caaggtgagc aacaaggccc tcccagcccc tatcgagaag      780

acaatctcca aggccaaggg ccaaccaagg gagcctcaag tgtatacact ccctcctagc      840

agagacgagc tcactaagaa tcaagtgtct ctgacttgtc tggtgaaggg cttttaccca      900

agcgacatcg ccgtggagtg ggagagcaac ggccaaccag agaacaacta caagacaact      960

cctccagtgc tggactccga cggcagcttc ttcctctaca gcaagctgac tgtggataag     1020

tccagatggc agcaaggcaa cgtcttcagc tgtagcgtga tgcacgaggc cctccacaac     1080

cactacacac agaagtctct gtctctgagc cccggcaaat aatag                     1125


<210>  13
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  13

Val Thr Ser Ser Pro Gly Thr Pro Ala Ser Cys Asp Lys Thr His Thr 
1               5                   10                  15      


Cys Pro Pro Cys Pro Ala Pro 
            20              


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  14

Ile Thr Gln Gln Asp Leu Ala 
1               5           


