                         SEQUENCE LISTING

<110>  UCB Biopharma SRL
       Element Genomics Inc
       UCB Biosciences Inc
 
<120>  Nucleic acid constructs, viral vectors and viral particles

<130>  PF0300-WO

<150>  US 63/089,817
<151>  2020-10-09

<160>  35    

<170>  PatentIn version 3.5

<210>  1
<211>  582
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAG promoter

<400>  1
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catgcgtcga ggtgagcccc acgttctgct tcactctccc catctccccc ccctccccac      360

ccccaatttt gtatttattt attttttaat tattttatgc agcgatgggg gcgggggggg      420

ggggggcgcg cgccaggcgg ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga      480

ggtgcggcgg cagccaatca gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg      540

cggcggcggc ggccctataa aaagcgaagc gcgcggcggg cg                         582


<210>  2
<211>  1011
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric intron

<400>  2
ggagtcgctg cgttgccttc gccccgtgcc ccgctccgcg ccgcctcgcg ccgcccgccc       60

cggctctgac tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctccctcc      120

gggctgtaat tagcgcttgg tttaatgacg gctcgtttct tttctgtggc tgcgtgaaag      180

ccttaaaggg ctccgggagg gcctttgtgc gggggggagc ggctcggggg gtgcgtgcgt      240

gtgtgtgtgc gtggggagcg ccgcgtgcgg cccgcgctgc ccggcggctg tgagcgctgc      300

gggcgcggcg cggggctttg tgcgctccgc gtgtgcgcga ggggagcgcg ggccgggggc      360

ggtgccccgc ggtgcggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg      420

tgggggggtg agcagggggt gtgggcgcgg cggtcgggct gtaacccccc cctggcaccc      480

ccctccccga gttgctgagc acggcccggc ttcgggtgcg gggctccgtg cggggcgtgg      540

cgcggggctc gccgtgccgg gcggggggtg gcggcaggtg ggggtgccgg gcggggcggg      600

gccgcctcgg gccggggagg gctcggggga ggggcgcggc ggccccggag cgccggcggc      660

tgtcgaggcg cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag      720

ggacttcctt tgtcccaaat ctggcggagc cgaaatctgg gaggcgccgc cgcaccccct      780

ctagcgggcg cgggcgaagc ggtgcggcgc cggcaggaag gaaatgggcg gggagggcct      840

tcgtgcgtcg ccgcgccgcc gtccccttct ccatctccag cctcggggct gccgcagggg      900

gacggctgcc ttcggggggg acggggcagg gcggggttcg gcttctggcg tgtgaccggc      960

ggctttagag cctctgctaa ccatgttcat gccttcttct ttttcctaca g              1011


<210>  3
<211>  1210
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  UCB promoter

<400>  3
ggcctccgcg ccgggttttg gcgcctcccg cgggcgcccc cctcgtcacg gcgagcgctg       60

ccacgtcaga cgaagggcgc aggagcgtcc tgatccttcc gcccggacgc tcaggacagc      120

ggcccgctgc tcataagact cggccttaga accccagtat cagcagaagg acattttagg      180

acgggacttg ggtgactcta gggcactggt tttctttcca gagagcggaa caggcgagga      240

aaagtagtcc cttctcggcg attctgcgga gggatctccg tggggcggtg aacgccgatg      300

attatataag gacgcgccgg gtgtggcaca gctagttccg tcgcagccgg gatttgggtc      360

gcggttcttg tttgtggatc gctgtgatcg tcacttggtg agtagcgggc tgctgggctg      420

gccggggctt tcgtggccgc cgggccgctc ggtgggacgg aagcgtgtgg agagaccgcc      480

aagggctgta gtctgggtcc gcgagcaagg ttgccctgaa ctgggggttg gggggagcgc      540

agcaaaatgg cggctgttcc cgagtcttga atggaagacg cttgtgaggc gggctgtgag      600

gtcgttgaaa caaggtgggg ggcatggtgg gcggcaagaa cccaaggtct tgagcccttc      660

gctaatgcgg gaaagctctt attcgggtga gatgggctgg gcaccatctg gggaccctga      720

cgtgaagttt gtcactgact ggagaactcg gtttgtcgtc tgttgcgggg gcggcagtta      780

tggcggtgcc gttgggcagt gcacccgtac ctttgggagc gcgcgccctc gtcgtgtcgt      840

gacgtcaccc gttctgttgg cttataatgc agggtggggc cacctgccgg taggtgtgcg      900

gtaggctttt ctccgtcgca ggacgcaggg ttcgggccta gggtaggctc tcctgaatcg      960

acaggcgccg gacctctggt gaggggaggg ataagtgagg cgtcagtttc tttggtcggt     1020

tttatgtacc tatcttctta agtagctgaa gctccggttt tgaactatgc gctcggggtt     1080

ggcgagtgtg ttttgtgaag ttttttaggc accttttgaa atgtaatcat ttgggtcaat     1140

atgtaatttt cagtgttaga cttgtaaatt gtccgctaaa ttctggccgt ttttggcttt     1200

tttgttagac                                                            1210


<210>  4
<211>  390
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PGK promoter

<400>  4
accggtaggc gccaaccggc tccgttcttt ggtggcccct tcgcgccacc ttctactcct       60

cccctagtca ggaagttccc ccccgccccg cagctcgcgt cgtgcaggac gtgacaaatg      120

gaagtagcac gtctcactag tctcgtgcag atggacagca ccgctgagca atggaagcgg      180

gtaggccttt ggggcagcgg ccaatagcag ctttgctcct tcgctttctg ggctcagagg      240

ctgggaaggg gtgggtccgg gggcgggctc aggggcgggc tcaggggcgg ggcgggcgcc      300

cgaaggtcct ccggaggccc ggcattctgc acgcttcaaa agcgcacgtc tgccgcgctg      360

ttctcctctt cctcatctcc gggcctttcg                                       390


<210>  5
<211>  1179
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EF1a promoter plus intron

<400>  5
ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga gaagttgggg       60

ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt      120

gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta tataagtgca      180

ctagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca ggtaagtgcc      240

gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt gccttgaatt      300

acttccacct ggctgcagta cgtgattctt gatcccgagc ttcgggttgg aagtgggtgg      360

gagagttcgt ggccttgcgc ttaaggagcc ccttcgcctc gtgcttgagt tgtggcctgg      420

cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc ttcgcgcctg tctcgctgct      480

ttcgataagt ctctagccat ttaaaatttt tgatgacctg ctgcgacgct ttttttctgg      540

caagatagtc ttgtaaatgc gggccaagat cagcacactg gtatttcggt ttttggggcc      600

gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt cggcgaggcg gggcctgcga      660

gcgcggccac cgagaatcgg acgggggtag tctcaagctg cccggcctgc tctggtgcct      720

ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa ggctggcccg gtcggcacca      780

gttgcgtgag cggaaagatg gccgcttccc ggccctgctg cagggagcac aaaatggagg      840

acgcggcgct cgggagagcg ggcgggtgag tcacccacac aaaggaaaag ggcctttccg      900

tcctcagccg tcgcttcatg tgactccacg gagtaccggg cgccgtccag gcacctcgat      960

tagttctcca gcttttggag tacgtcgtct ttaggttggg gggaggggtt ttatgcgatg     1020

gagtttcccc acactgagtg ggtggagact gaagttaggc cagcttggca cttgatgtaa     1080

ttctccttgg aatttgccct ttttgagttt ggatcttggt tcattctcaa gcctcagaca     1140

gtggttcaaa gtttttttct tccatttcag gtgtcgtga                            1179


<210>  6
<211>  939
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EF1a intron

<400>  6
gtaagtgccg tgtgtggttc ccgcgggcct ggcctcttta cgggttatgg cccttgcgtg       60

ccttgaatta cttccacctg gctgcagtac gtgattcttg atcccgagct tcgggttgga      120

agtgggtggg agagttcgtg gccttgcgct taaggagccc cttcgcctcg tgcttgagtt      180

gtggcctggc ctgggcgctg gggccgccgc gtgcgaatct ggtggcacct tcgcgcctgt      240

ctcgctgctt tcgataagtc tctagccatt taaaattttt gatgacctgc tgcgacgctt      300

tttttctggc aagatagtct tgtaaatgcg ggccaagatc agcacactgg tatttcggtt      360

tttggggccg cgggcggcga cggggcccgt gcgtcccagc gcacatgttc ggcgaggcgg      420

ggcctgcgag cgcggccacc gagaatcgga cgggggtagt ctcaagctgc ccggcctgct      480

ctggtgcctg gcctcgcgcc gccgtgtatc gccccgccct gggcggcaag gctggcccgg      540

tcggcaccag ttgcgtgagc ggaaagatgg ccgcttcccg gccctgctgc agggagcaca      600

aaatggagga cgcggcgctc gggagagcgg gcgggtgagt cacccacaca aaggaaaagg      660

gcctttccgt cctcagccgt cgcttcatgt gactccacgg agtaccgggc gccgtccagg      720

cacctcgatt agttctccag cttttggagt acgtcgtctt taggttgggg ggaggggttt      780

tatgcgatgg agtttcccca cactgagtgg gtggagactg aagttaggcc agcttggcac      840

ttgatgtaat tctccttgga atttgccctt tttgagtttg gatcttggtt cattctcaag      900

cctcagacag tggttcaaag tttttttctt ccatttcag                             939


<210>  7
<211>  229
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MECP2 promoter

<400>  7
agctgaatgg ggtccgcctc ttttccctgc ctaaacagac aggaactcct gccaattgag       60

ggcgtcaccg ctaaggctcc gccccagcct gggctccaca accaatgaag ggtaatctcg      120

acaaagagca aggggtgggg cgcgggcgcg caggtgcagc agcacacagg ctggtcggga      180

gggcggggcg cgacgtctgc cgtgcggggt cccggcatcg gttgcgcgc                  229


<210>  8
<211>  1317
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hNSE promoter

<400>  8
atgcagctgg acctaggaga gaagcaggag aggaagatcc agcacaaaaa atccgaagct       60

aaaaacagga cacagagatg ggggaagaaa agagggcaga gtgaggcaaa aagagactga      120

agagatgagg gtggccgcca ggcactttag ataggggaga ggctttattt acctctgttt      180

gttttttttt tttttttttt tttttttttt ttgcgaggta gtcttgctta gtctccaggc      240

tggagtgcag tggcacaatc tcagctcact gcaacttcca cctcctgggt tcaagcaatt      300

ctcctgcctc agcctcccga gtagctggga ctacaggcgc atgcaaccgc gcctggctaa      360

tttttgtatt tttagtagaa acggggtttc accacgttag ccaggatggt ctggatctcc      420

tgacctcgtg atctgcccgc ctccgccttc caaagtgctg ggattacagg ggtgagccac      480

agcgcctggt ccctatttac ttctgtcttc tacctccagg agatcaaaga cgctggcctt      540

cagacctgat cagactccca ggggcagcca ccacatgtat gacagagaac agaggatgcc      600

tgtttttgcc ccaaagctgg aaattcatca caacctgagg cccaggatct gctctgtgcc      660

ggtcctctgg gcagtgtggg gtgcagaatg gggtgcctag gcctgagcgt tgcctggagc      720

ctaggccggg ggccgccctc gggcaggcgt gggtgagagc caagaccgcg tgggccgcgg      780

ggtgctggta ggagtggttg gagagacttg cgaaggcggc tggggtgttc ggatttccaa      840

taaagaaaca gagtgatgct cctgtgtctg accgggtttg tgagacattg aggctgtctt      900

gggcttcact ggcagtgtgg gccttcgtac ccgggctaca ggggtgcggc tctgcctgtt      960

actgtcgagt gggtcgggcc gtgggtatga gcgcttgtgt gcgctggggc caggtcgtgg     1020

gtgcccccac ccttccccca tcctcctccc ttccccactc caccctcgtc ggtcccccac     1080

ccgcgctcgt acgtgcgcct ccgccggcag ctcctgactc atcgggggct ccgggtcaca     1140

tgcgcccgcg cggccctata ggcgcctcct ccgcccgccg cccgggagcc gcagccgccg     1200

ccgccactgc cactcccgct ctctcagcgc cgccgtcgcc accgccaccg ccaccgccac     1260

taccaccgag atctgcgatc taagtaagct tggcattccg gtactgttgg taaagcc        1317


<210>  9
<211>  448
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hSyn promoter

<400>  9
agtgcaagtg ggttttagga ccaggatgag gcggggtggg ggtgcctacc tgacgaccga       60

ccccgaccca ctggacaagc acccaacccc cattccccaa attgcgcatc ccctatcaga      120

gagggggagg ggaaacagga tgcggcgagg cgcgtgcgca ctgccagctt cagcaccgcg      180

gacagtgcct tcgcccccgc ctggcggcgc gcgccaccgc cgcctcagca ctgaaggcgc      240

gctgacgtca ctcgccggtc ccccgcaaac tccccttccc ggccaccttg gtcgcgtccg      300

cgccgccgcc ggcccagccg gaccgcacca cgcgaggcgc gagatagggg ggcacgggcg      360

cgaccatctg cgctgcggcg ccggcgactc agcgctgcct cagtctgcgg tgggcagcgg      420

aggagtcgtg tcgtgcctga gagcgcag                                         448


<210>  10
<211>  1289
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CamKII promoter

<400>  10
cattatggcc ttaggtcact tcatctccat ggggttcttc ttctgatttt ctagaaaatg       60

agatgggggt gcagagagct tcctcagtga cctgcccagg gtcacatcag aaatgtcaga      120

gctagaactt gaactcagat tactaatctt aaattccatg ccttgggggc atgcaagtac      180

gatatacaga aggagtgaac tcattagggc agatgaccaa tgagtttagg aaagaagagt      240

ccagggcagg gtacatctac accacccgcc cagccctggg tgagtccagc cacgttcacc      300

tcattatagt tgcctctctc cagtcctacc ttgacgggaa gcacaagcag aaactgggac      360

aggagcccca ggagaccaaa tcttcatggt ccctctggga ggatgggtgg ggagagctgt      420

ggcagaggcc tcaggagggg ccctgctgct cagtggtgac agataggggt gagaaagcag      480

acagagtcat tccgtcagca ttctgggtct gtttggtact tcttctcacg ctaaggtggc      540

ggtgtgatat gcacaatggc taaaaagcag ggagagctgg aaagaaacaa ggacagagac      600

agaggccaag tcaaccagac caattcccag aggaagcaaa gaaaccatta cagagactac      660

aagggggaag ggaaggagag atgaattagc ttcccctgta aaccttagaa cccagctgtt      720

gccagggcaa cggggcaata cctgtctctt cagaggagat gaagttgcca gggtaactac      780

atcctgtctt tctcaaggac catcccagaa tgtggcaccc actagccgtt accatagcaa      840

ctgcctcttt gccccactta atcccatccc gtctgttaaa agggccctat agttggaggt      900

gggggaggta ggaagagcga tgatcacttg tggactaagt ttgttcgcat ccccttctcc      960

aaccccctca gtacatcacc ctgggggaac agggtccact tgctcctggg cccacacagt     1020

cctgcagtat tgtgtatata aggccagggc aaagaggagc aggttttaaa gtgaaaggca     1080

ggcaggtgtt ggggaggcag ttaccggggc aacgggaaca gggcgtttcg gaggtggttg     1140

ccatggggac ctggatgctg acgaaggctc gcgaggctgt gagcagccac agtgccctgc     1200

tcagaagccc caagctcgtc agtcaagccg gttctccgtt tgcactcagg agcacgggca     1260

ggcgagtggc ccctagttct gggggcagc                                       1289


<210>  11
<211>  541
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hDLX promoter

<400>  11
ttcagaatgt tatgcactca cagtggtttg gcatgcatct ggtgaatttt ttttaacgaa       60

aaattagtgt tggtttcgat gtatggtagc attctcccta acgtaatttg aataattcag      120

caaagcccca ctaccagctg tacttctgca gcctcttcca ttcttttcag cattataatt      180

ttggttaatt ttcaatttta ggtcctacgt ctctgcaatt tgtgtatgaa taacagaata      240

atttccctct tttgtttcgc ctttcctgtt cctgaatcta aataaagatg gctttttagt      300

attaaaagtg gaagaaaatt acaggtaatt atctttgacg gtaaaaacgc tgtaatcagc      360

gggctacatg aaaaattact ctaattatgg ctgcatttaa gagaatggaa aaaaaccttc      420

ttgtggataa aaaccttaaa ttgtccccaa tgtctgcttc aaattggatg gcactgcagc      480

tggaggcttt gttcagaatt gatcctgggg agctacgaac ccaaagtttc acagtaggaa      540

g                                                                      541


<210>  12
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pB Globin

<400>  12
ctgggcataa aagtcagggc agagccatct attgcttaca tttgcttct                   49


<210>  13
<211>  133
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hDLX intron

<400>  13
gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga       60

cagagaagac tcttgcgttt ctgataggca cctattggtc ttactgacat ccactttgcc      120

tttctctcca cag                                                         133


<210>  14
<211>  1296
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Endogenous hSLC6A1 promoter

<400>  14
agaatccctc aaacctcaag aactgagaga agggtgtctg gggctcctgc caccatccct       60

gtttcccttt taagtaatct gtttccccat ctgtccatcc atacacacag ccacttgtgt      120

ctccatgacc aaccgctggc agtggaaggg tgtccttccc acccccactc ttacacacac      180

tcccagctgg tacccagagc ctggtcaccc caggccaggc ctgtgtttcc aggtgtaacg      240

ggcagcagac gctgccctag gactagagca gggagggggc acgggcccac cccaacccac      300

agcgacccac agagggcgaa aagaggacga ccgcagagag aaacggaaag gacaggccaa      360

cggaagcagt actgcaaggc tggaaggaga aaagccagga ggggagtgct tgctgtgaaa      420

gacagggaga cagagaccaa gacggacagg cagacaggct ggtgacccag gatgaggccg      480

gaaagagcca tcaaaggaag gagaaggaag gagagagatt ggagcgggac ggcggggcag      540

gcgagggaag gagggggtgg ggagagggag ggaggaagag aggggagaaa gagggaggaa      600

gagaggggag aaggagggag aagagagcgg gagaatgcga gaggaaagaa gggagagggg      660

aggcgtagaa ggggagagga ggtgaaggga aaaggagaga gcctgctggc ggcgaagctg      720

caagaggcag ctgcggaggg agcgcgcggc gggcctgggg gagcgctggg cgggggcggg      780

cggtgcgggc agggctatac ccgagctggg cgggctccgg gcgccgcggg ccctgccctc      840

cccctccatc cctccggact cgctcccccc tcctctccct tccccgcgac cctccgcccg      900

ccctcggaag accgagacag cggagaggtt gcgggtgagc tgcgctgagc ccaggagccg      960

aggagtcggg agcgcagtag cgctgagccc gagcccgagc ggccccgcgt cccgagcgca     1020

tcggagcggc cgagccgccc ggatgcagcg cctgtcccgg gcagcgcagc cccggccgca     1080

ggatctcacc cagggtggca gaaggaggcc ttctggagct gacccacccc cgacgaccat     1140

cagggtgagg caactccaag gtcctactct ctttctgtgc ctgttaccca ccccgtcctc     1200

ctagggtgcc cttgagccgc aaaactgctg tccacgtgga ccgggggtga catcgcacgt     1260

ccatctgcca ggacccctgc gtccaaattc cgagac                               1296


<210>  15
<211>  1800
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human SLC6A1

<400>  15
atggcgacca acggcagcaa ggtggccgac gggcagatct ccaccgaggt cagcgaggcc       60

cctgtggcca atgacaagcc caaaaccttg gtggtcaagg tgcagaagaa ggcggcagac      120

ctccccgacc gggacacgtg gaagggccgc ttcgacttcc tcatgtcctg tgtgggctat      180

gccatcggcc tgggcaacgt ctggaggttc ccctatctct gcgggaaaaa tggtggggga      240

gccttcctga tcccctattt cctgacactc atctttgcgg gggtcccact cttcctgctg      300

gagtgctccc tgggccagta cacctccatc ggggggctag gggtatggaa gctggctcct      360

atgttcaagg gcgtgggcct tgcggctgct gtgctatcat tctggctgaa catctactac      420

atcgtcatca tctcctgggc catttactac ctgtacaact ccttcaccac gacactgccg      480

tggaaacagt gcgacaaccc ctggaacaca gaccgctgct tctccaacta cagcatggtc      540

aacactacca acatgaccag cgctgtggtg gagttctggg agcgcaacat gcatcagatg      600

acggacgggc tggataagcc aggtcagatc cgctggccac tggccatcac gctggccatc      660

gcctggatcc ttgtgtattt ctgtatctgg aagggtgttg gctggactgg aaaggtggtc      720

tacttttcag ccacataccc ctacatcatg ctgatcatcc tgttcttccg tggagtgacg      780

ctgcccgggg ccaaggaggg catcctcttc tacatcacac ccaacttccg caagctgtct      840

gactccgagg tgtggctgga tgcggcaacc cagatcttct tctcatacgg gctgggcctg      900

gggtccctga tcgctctcgg gagctacaac tctttccaca acaatgtcta cagggactcc      960

atcatcgtct gctgcatcaa ttcgtgcacc agcatgttcg caggattcgt catcttctcc     1020

atcgtgggct tcatggccca tgtcaccaag aggtccattg ctgatgtggc ggcctcaggc     1080

cccgggctgg cgttcctggc atacccagag gcggtgaccc agctgcctat ctccccactc     1140

tgggccatcc tcttcttctc catgctgttg atgctgggca ttgacagcca gttctgcact     1200

gtggagggct tcatcacagc cctggtggat gagtacccca ggctcctccg caaccgcaga     1260

gagctcttca ttgctgctgt ctgcatcatc tcctacctga tcggtctctc taacatcact     1320

caggggggta tttatgtctt caaactcttt gactactact ctgccagtgg catgagcctg     1380

ctgttcctcg tgttctttga atgtgtctct atttcctggt tttacggtgt caaccgattc     1440

tatgacaata tccaagagat ggttggatcc aggccctgca tctggtggaa actctgctgg     1500

tctttcttca caccaatcat tgtggcgggc gtgttcattt tcagtgctgt gcagatgacg     1560

ccactcacca tgggaaacta tgttttcccc aagtggggcc agggtgtggg ctggctgatg     1620

gctctgtctt ccatggtcct catccccggg tacatggcct acatgttcct caccttaaag     1680

ggctccctga agcagcgcat ccaagtcatg gtccagccca gcgaagacat cgttcgccca     1740

gagaatggtc ctgagcagcc ccaggcgggc agctccacca gcaaggaggc ctacatctag     1800


<210>  16
<211>  1800
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse SLC6A1

<400>  16
atggcgactg acaacagcaa ggtggctgat gggcagatct ctactgaggt cagcgaggcc       60

cctgtggcca gcgacaagcc caaaaccctg gtagtcaagg tgcagaagaa ggccggggac      120

ctccctgacc gggacacatg gaagggacgc ttcgacttcc tcatgtcctg cgtgggctat      180

gccatcggcc tgggcaatgt gtggaggttc ccttacctct gtgggaaaaa cggtggcggg      240

gccttcctaa tcccatattt cctgacgctc atctttgcgg gtgttcctct cttccttttg      300

gagtgctccc taggccagta cacctccatt gggggcctgg gcgtatggaa gctggcgccc      360

atgttcaagg gtgtgggcct cgcggcagct gtgctgtcct tctggctgaa catctactac      420

atcgtcatca tctcctgggc catctactac ctgtacaact ccttcaccac gaccctgcca      480

tggaaacagt gtgacaaccc gtggaacact gaccgctgct tctccaacta cagcctggtc      540

aataccacca acatgaccag cgccgtggtg gagttctggg agcgcaacat gcaccagatg      600

acagatggac tggacaagcc aggacagatc cgctggcctc tggccatcac actggccatt      660

gcctgggtgc tcgtgtattt ctgcatctgg aagggtgttg gttggactgg aaaggtggtc      720

tacttctcag ccacgtaccc ctacatcatg cttatcatcc tgttcttccg tggagtgacg      780

cttcccgggg ccaaggaggg gatcctcttc tacatcacac ccaacttccg aaagctgtct      840

gattctgagg tgtggcttga cgccgccacc cagatcttct tctcctacgg gctgggcctg      900

gggtccctga ttgctctggg aagctacaac tctttccaca acaatgtgta cagggactcc      960

atcatcgttt gctgcatcaa ctcctgcacc agcatgtttg ccggattcgt catcttctcc     1020

atcgtgggct tcatggctca tgtcaccaag aggtccatag ctgatgtggc agcctcaggc     1080

ccggggctgg cattcttggc gtaccctgag gctgtgacac agctacccat ctctcccctc     1140

tgggctatcc tcttcttctc catgctgctg atgctgggca ttgacagcca gttctgtacc     1200

gtggagggct tcatcactgc cctggtggac gagtacccca gacttctccg caatcgccgt     1260

gaactcttca ttgctgccgt gtgcatcgtg tcctacctga ttggcctgtc taacatcacc     1320

cagggtggca tttatgtctt caaactgttt gattattact ctgccagcgg catgagcttg     1380

ctgttcctgg ttttcttcga gtgtgtctcc atttcctggt tttatggtgt caaccggttc     1440

tatgacaaca tccaggagat ggttggctcc aggccctgca tctggtggaa gctgtgctgg     1500

tcctttttca cacccatcat tgtggcgggc gtgtttctct tcagtgctgt gcagatgaca     1560

ccactcacca tgggaagcta tgttttcccc aagtggggcc agggcgtggg ctggctcatg     1620

gctctgtcct ccatggtgct catccccggg tacatggctt acatgttcct caccctgaag     1680

ggctccctga agcagcgtct ccaggtcatg attcagccca gtgaagatat tgtgcgccct     1740

gagaatggcc ctgagcagcc gcaggctggc agctcagcca gcaaggaggc ctacatctag     1800


<210>  17
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SV40 poly A

<400>  17
gatccagaca tgataagata cattgatgag tttggacaaa ccacaactag aatgcagtga       60

aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac cattataagc      120

tgcaataaac aagtt                                                       135


<210>  18
<211>  599
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human GAT-1 isoform a

<400>  18

Met Ala Thr Asn Gly Ser Lys Val Ala Asp Gly Gln Ile Ser Thr Glu 
1               5                   10                  15      


Val Ser Glu Ala Pro Val Ala Asn Asp Lys Pro Lys Thr Leu Val Val 
            20                  25                  30          


Lys Val Gln Lys Lys Ala Ala Asp Leu Pro Asp Arg Asp Thr Trp Lys 
        35                  40                  45              


Gly Arg Phe Asp Phe Leu Met Ser Cys Val Gly Tyr Ala Ile Gly Leu 
    50                  55                  60                  


Gly Asn Val Trp Arg Phe Pro Tyr Leu Cys Gly Lys Asn Gly Gly Gly 
65                  70                  75                  80  


Ala Phe Leu Ile Pro Tyr Phe Leu Thr Leu Ile Phe Ala Gly Val Pro 
                85                  90                  95      


Leu Phe Leu Leu Glu Cys Ser Leu Gly Gln Tyr Thr Ser Ile Gly Gly 
            100                 105                 110         


Leu Gly Val Trp Lys Leu Ala Pro Met Phe Lys Gly Val Gly Leu Ala 
        115                 120                 125             


Ala Ala Val Leu Ser Phe Trp Leu Asn Ile Tyr Tyr Ile Val Ile Ile 
    130                 135                 140                 


Ser Trp Ala Ile Tyr Tyr Leu Tyr Asn Ser Phe Thr Thr Thr Leu Pro 
145                 150                 155                 160 


Trp Lys Gln Cys Asp Asn Pro Trp Asn Thr Asp Arg Cys Phe Ser Asn 
                165                 170                 175     


Tyr Ser Met Val Asn Thr Thr Asn Met Thr Ser Ala Val Val Glu Phe 
            180                 185                 190         


Trp Glu Arg Asn Met His Gln Met Thr Asp Gly Leu Asp Lys Pro Gly 
        195                 200                 205             


Gln Ile Arg Trp Pro Leu Ala Ile Thr Leu Ala Ile Ala Trp Ile Leu 
    210                 215                 220                 


Val Tyr Phe Cys Ile Trp Lys Gly Val Gly Trp Thr Gly Lys Val Val 
225                 230                 235                 240 


Tyr Phe Ser Ala Thr Tyr Pro Tyr Ile Met Leu Ile Ile Leu Phe Phe 
                245                 250                 255     


Arg Gly Val Thr Leu Pro Gly Ala Lys Glu Gly Ile Leu Phe Tyr Ile 
            260                 265                 270         


Thr Pro Asn Phe Arg Lys Leu Ser Asp Ser Glu Val Trp Leu Asp Ala 
        275                 280                 285             


Ala Thr Gln Ile Phe Phe Ser Tyr Gly Leu Gly Leu Gly Ser Leu Ile 
    290                 295                 300                 


Ala Leu Gly Ser Tyr Asn Ser Phe His Asn Asn Val Tyr Arg Asp Ser 
305                 310                 315                 320 


Ile Ile Val Cys Cys Ile Asn Ser Cys Thr Ser Met Phe Ala Gly Phe 
                325                 330                 335     


Val Ile Phe Ser Ile Val Gly Phe Met Ala His Val Thr Lys Arg Ser 
            340                 345                 350         


Ile Ala Asp Val Ala Ala Ser Gly Pro Gly Leu Ala Phe Leu Ala Tyr 
        355                 360                 365             


Pro Glu Ala Val Thr Gln Leu Pro Ile Ser Pro Leu Trp Ala Ile Leu 
    370                 375                 380                 


Phe Phe Ser Met Leu Leu Met Leu Gly Ile Asp Ser Gln Phe Cys Thr 
385                 390                 395                 400 


Val Glu Gly Phe Ile Thr Ala Leu Val Asp Glu Tyr Pro Arg Leu Leu 
                405                 410                 415     


Arg Asn Arg Arg Glu Leu Phe Ile Ala Ala Val Cys Ile Ile Ser Tyr 
            420                 425                 430         


Leu Ile Gly Leu Ser Asn Ile Thr Gln Gly Gly Ile Tyr Val Phe Lys 
        435                 440                 445             


Leu Phe Asp Tyr Tyr Ser Ala Ser Gly Met Ser Leu Leu Phe Leu Val 
    450                 455                 460                 


Phe Phe Glu Cys Val Ser Ile Ser Trp Phe Tyr Gly Val Asn Arg Phe 
465                 470                 475                 480 


Tyr Asp Asn Ile Gln Glu Met Val Gly Ser Arg Pro Cys Ile Trp Trp 
                485                 490                 495     


Lys Leu Cys Trp Ser Phe Phe Thr Pro Ile Ile Val Ala Gly Val Phe 
            500                 505                 510         


Ile Phe Ser Ala Val Gln Met Thr Pro Leu Thr Met Gly Asn Tyr Val 
        515                 520                 525             


Phe Pro Lys Trp Gly Gln Gly Val Gly Trp Leu Met Ala Leu Ser Ser 
    530                 535                 540                 


Met Val Leu Ile Pro Gly Tyr Met Ala Tyr Met Phe Leu Thr Leu Lys 
545                 550                 555                 560 


Gly Ser Leu Lys Gln Arg Ile Gln Val Met Val Gln Pro Ser Glu Asp 
                565                 570                 575     


Ile Val Arg Pro Glu Asn Gly Pro Glu Gln Pro Gln Ala Gly Ser Ser 
            580                 585                 590         


Thr Ser Lys Glu Ala Tyr Ile 
        595                 


<210>  19
<211>  421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human GAT-1 isoform b

<400>  19

Met Val Asn Thr Thr Asn Met Thr Ser Ala Val Val Glu Phe Trp Glu 
1               5                   10                  15      


Arg Asn Met His Gln Met Thr Asp Gly Leu Asp Lys Pro Gly Gln Ile 
            20                  25                  30          


Arg Trp Pro Leu Ala Ile Thr Leu Ala Ile Ala Trp Ile Leu Val Tyr 
        35                  40                  45              


Phe Cys Ile Trp Lys Gly Val Gly Trp Thr Gly Lys Val Val Tyr Phe 
    50                  55                  60                  


Ser Ala Thr Tyr Pro Tyr Ile Met Leu Ile Ile Leu Phe Phe Arg Gly 
65                  70                  75                  80  


Val Thr Leu Pro Gly Ala Lys Glu Gly Ile Leu Phe Tyr Ile Thr Pro 
                85                  90                  95      


Asn Phe Arg Lys Leu Ser Asp Ser Glu Val Trp Leu Asp Ala Ala Thr 
            100                 105                 110         


Gln Ile Phe Phe Ser Tyr Gly Leu Gly Leu Gly Ser Leu Ile Ala Leu 
        115                 120                 125             


Gly Ser Tyr Asn Ser Phe His Asn Asn Val Tyr Arg Asp Ser Ile Ile 
    130                 135                 140                 


Val Cys Cys Ile Asn Ser Cys Thr Ser Met Phe Ala Gly Phe Val Ile 
145                 150                 155                 160 


Phe Ser Ile Val Gly Phe Met Ala His Val Thr Lys Arg Ser Ile Ala 
                165                 170                 175     


Asp Val Ala Ala Ser Gly Pro Gly Leu Ala Phe Leu Ala Tyr Pro Glu 
            180                 185                 190         


Ala Val Thr Gln Leu Pro Ile Ser Pro Leu Trp Ala Ile Leu Phe Phe 
        195                 200                 205             


Ser Met Leu Leu Met Leu Gly Ile Asp Ser Gln Phe Cys Thr Val Glu 
    210                 215                 220                 


Gly Phe Ile Thr Ala Leu Val Asp Glu Tyr Pro Arg Leu Leu Arg Asn 
225                 230                 235                 240 


Arg Arg Glu Leu Phe Ile Ala Ala Val Cys Ile Ile Ser Tyr Leu Ile 
                245                 250                 255     


Gly Leu Ser Asn Ile Thr Gln Gly Gly Ile Tyr Val Phe Lys Leu Phe 
            260                 265                 270         


Asp Tyr Tyr Ser Ala Ser Gly Met Ser Leu Leu Phe Leu Val Phe Phe 
        275                 280                 285             


Glu Cys Val Ser Ile Ser Trp Phe Tyr Gly Val Asn Arg Phe Tyr Asp 
    290                 295                 300                 


Asn Ile Gln Glu Met Val Gly Ser Arg Pro Cys Ile Trp Trp Lys Leu 
305                 310                 315                 320 


Cys Trp Ser Phe Phe Thr Pro Ile Ile Val Ala Gly Val Phe Ile Phe 
                325                 330                 335     


Ser Ala Val Gln Met Thr Pro Leu Thr Met Gly Asn Tyr Val Phe Pro 
            340                 345                 350         


Lys Trp Gly Gln Gly Val Gly Trp Leu Met Ala Leu Ser Ser Met Val 
        355                 360                 365             


Leu Ile Pro Gly Tyr Met Ala Tyr Met Phe Leu Thr Leu Lys Gly Ser 
    370                 375                 380                 


Leu Lys Gln Arg Ile Gln Val Met Val Gln Pro Ser Glu Asp Ile Val 
385                 390                 395                 400 


Arg Pro Glu Asn Gly Pro Glu Gln Pro Gln Ala Gly Ser Ser Thr Ser 
                405                 410                 415     


Lys Glu Ala Tyr Ile 
            420     


<210>  20
<211>  421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human GAT-1 isoform c

<400>  20

Met Val Asn Thr Thr Asn Met Thr Ser Ala Val Val Glu Phe Trp Glu 
1               5                   10                  15      


Arg Asn Met His Gln Met Thr Asp Gly Leu Asp Lys Pro Gly Gln Ile 
            20                  25                  30          


Arg Trp Pro Leu Ala Ile Thr Leu Ala Ile Ala Trp Ile Leu Val Tyr 
        35                  40                  45              


Phe Cys Ile Trp Lys Gly Val Gly Trp Thr Gly Lys Val Val Tyr Phe 
    50                  55                  60                  


Ser Ala Thr Tyr Pro Tyr Ile Met Leu Ile Ile Leu Phe Phe Arg Gly 
65                  70                  75                  80  


Val Thr Leu Pro Gly Ala Lys Glu Gly Ile Leu Phe Tyr Ile Thr Pro 
                85                  90                  95      


Asn Phe Arg Lys Leu Ser Asp Ser Glu Val Trp Leu Asp Ala Ala Thr 
            100                 105                 110         


Gln Ile Phe Phe Ser Tyr Gly Leu Gly Leu Gly Ser Leu Ile Ala Leu 
        115                 120                 125             


Gly Ser Tyr Asn Ser Phe His Asn Asn Val Tyr Arg Asp Ser Ile Ile 
    130                 135                 140                 


Val Cys Cys Ile Asn Ser Cys Thr Ser Met Phe Ala Gly Phe Val Ile 
145                 150                 155                 160 


Phe Ser Ile Val Gly Phe Met Ala His Val Thr Lys Arg Ser Ile Ala 
                165                 170                 175     


Asp Val Ala Ala Ser Gly Pro Gly Leu Ala Phe Leu Ala Tyr Pro Glu 
            180                 185                 190         


Ala Val Thr Gln Leu Pro Ile Ser Pro Leu Trp Ala Ile Leu Phe Phe 
        195                 200                 205             


Ser Met Leu Leu Met Leu Gly Ile Asp Ser Gln Phe Cys Thr Val Glu 
    210                 215                 220                 


Gly Phe Ile Thr Ala Leu Val Asp Glu Tyr Pro Arg Leu Leu Arg Asn 
225                 230                 235                 240 


Arg Arg Glu Leu Phe Ile Ala Ala Val Cys Ile Ile Ser Tyr Leu Ile 
                245                 250                 255     


Gly Leu Ser Asn Ile Thr Gln Gly Gly Ile Tyr Val Phe Lys Leu Phe 
            260                 265                 270         


Asp Tyr Tyr Ser Ala Ser Gly Met Ser Leu Leu Phe Leu Val Phe Phe 
        275                 280                 285             


Glu Cys Val Ser Ile Ser Trp Phe Tyr Gly Val Asn Arg Phe Tyr Asp 
    290                 295                 300                 


Asn Ile Gln Glu Met Val Gly Ser Arg Pro Cys Ile Trp Trp Lys Leu 
305                 310                 315                 320 


Cys Trp Ser Phe Phe Thr Pro Ile Ile Val Ala Gly Val Phe Ile Phe 
                325                 330                 335     


Ser Ala Val Gln Met Thr Pro Leu Thr Met Gly Asn Tyr Val Phe Pro 
            340                 345                 350         


Lys Trp Gly Gln Gly Val Gly Trp Leu Met Ala Leu Ser Ser Met Val 
        355                 360                 365             


Leu Ile Pro Gly Tyr Met Ala Tyr Met Phe Leu Thr Leu Lys Gly Ser 
    370                 375                 380                 


Leu Lys Gln Arg Ile Gln Val Met Val Gln Pro Ser Glu Asp Ile Val 
385                 390                 395                 400 


Arg Pro Glu Asn Gly Pro Glu Gln Pro Gln Ala Gly Ser Ser Thr Ser 
                405                 410                 415     


Lys Glu Ala Tyr Ile 
            420     


<210>  21
<211>  6922
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV9 hu14

<400>  21
agaaaaactc atcgagcatc aaatgaaatt gcaatttatt catatcagga ttatcaatac       60

catatttttg aaaaagccgt ttctgtaatg aaggagaaaa ctcaccgagg cagttccata      120

ggatggcaag atcctggtat cggtctgcga ttccgactcg tccaacatca atacaaccta      180

ttaatttccc ctcgtcaaaa ataaggttat caagtgagaa atcaccatga gtgacgactg      240

aatccggtga gaatggcaaa agtttatgca tttctttcca gacttgttca acaggccagc      300

cattacgctc gtcatcaaaa tcactcgcat caaccaaacc gttattcatt cgtgattgcg      360

cctgagcgag gcgaaatacg cgatcgctgt taaaaggaca attacaaaca ggaatcgagt      420

gcaaccggcg caggaacact gccagcgcat caacaatatt ttcacctgaa tcaggatatt      480

cttctaatac ctggaacgct gtttttccgg ggatcgcagt ggtgagtaac catgcatcat      540

caggagtacg gataaaatgc ttgatggtcg gaagtggcat aaattccgtc agccagttta      600

gtctgaccat ctcatctgta acatcattgg caacgctacc tttgccatgt ttcagaaaca      660

actctggcgc atcgggcttc ccatacaagc gatagattgt cgcacctgat tgcccgacat      720

tatcgcgagc ccatttatac ccatataaat cagcatccat gttggaattt aatcgcggcc      780

tcgacgtttc ccgttgaata tggctcatat tcttcctttt tcaatattat tgaagcattt      840

atcagggtta ttgtctcatg agcggataca tatttgaatg tatttagaaa aataaacaaa      900

taggggtcag tgttacaacc aattaaccaa ttctgaacat tatcgcgagc ccatttatac      960

ctgaatatgg ctcataacac cccttgtttg cctggcggca gtagcgcggt ggtcccacct     1020

gaccccatgc cgaactcaga agtgaaacgc cgtagcgccg atggtagtgt ggggactccc     1080

catgcgagag tagggaactg ccaggcatca aataaaacga aaggctcagt cgaaagactg     1140

ggcctttcgc ccgggctaat tagggggtgt cgcccttcgc tgaagtcctg tattagaggt     1200

cacgtgagtg ttttgcgaca ttttgcgaca ccatgtggtc acgctgggta tttaagcccg     1260

agtgagcacg cagggtctcc attttgaagc gggaggtttg aacgcgcagc cgccatgccg     1320

gggttttacg agattgtgat taaggtcccc agcgaccttg acgagcatct gcccggcatt     1380

tctgacagct ttgtgaactg ggtggccgag aaggaatggg agttgccgcc agattctgac     1440

atggatctga atctgattga gcaggcaccc ctgaccgtgg ccgagaagct gcagcgcgac     1500

tttctgacgg aatggcgccg tgtgagtaag gccccggagg cccttttctt tgtgcaattt     1560

gagaagggag agagctactt ccacatgcac gtgctcgtgg aaaccaccgg ggtgaaatcc     1620

atggttttgg gacgtttcct gagtcagatt cgcgaaaaac tgattcagag aatttaccgc     1680

gggatcgagc cgactttgcc aaactggttc gcggtcacaa agaccagaaa tggcgccgga     1740

ggcgggaaca aggtggtgga tgagtgctac atccccaatt acttgctccc caaaacccag     1800

cctgagctcc agtgggcgtg gactaatatg gaacagtatt taagcgcctg tttgaatctc     1860

acggagcgta aacggttggt ggcgcagcat ctgacgcacg tgtcgcagac gcaggagcag     1920

aacaaagaga atcagaatcc caattctgat gcgccggtga tcagatcaaa aacttcagcc     1980

aggtacatgg agctggtcgg gtggctcgtg gacaagggga ttacctcgga gaagcagtgg     2040

atccaggagg accaggcctc atacatctcc ttcaatgcgg cctccaactc gcggtcccaa     2100

atcaaggctg ccttggacaa tgcgggaaag attatgagcc tgactaaaac cgcccccgac     2160

tacctggtgg gccagcagcc cgtggaggac atttccagca atcggattta taaaattttg     2220

gaactaaacg ggtacgatcc ccaatatgcg gcttccgtct ttctgggatg ggccacgaaa     2280

aagttcggca agaggaacac catctggctg tttgggcctg caactaccgg gaagaccaac     2340

atcgcggagg ccatagccca cactgtgccc ttctacgggt gcgtaaactg gaccaatgag     2400

aactttccct tcaacgactg tgtcgacaag atggtgatct ggtgggagga ggggaagatg     2460

accgccaagg tcgtggagtc ggccaaagcc attctcggag gaagcaaggt gcgcgtggac     2520

cagaaatgca agtcctcggc ccagatagac ccgactcccg tgatcgtcac ctccaacacc     2580

aacatgtgcg ccgtgattga cgggaactca acgaccttcg aacaccagca gccgttgcaa     2640

gaccggatgt tcaaatttga actcacccgc cgtctggatc atgactttgg gaaggtcacc     2700

aagcaggaag tcaaagactt tttccggtgg gcaaaggatc acgtggttga ggtggagcat     2760

gaattctacg tcaaaaaggg tggagccaag aaaagacccg cccccagtga cgcagatata     2820

agtgagccca aacgggtgcg cgagtcagtt gcgcagccat cgacgtcaga cgcggaagct     2880

tcgatcaact acgcaggaca ggtaccaaaa caaatgttct cgtcacgtgg gcatgaatct     2940

gatgctgttt ccctgcagac aatgcgagag actgaatcag aattcaaata tctgcttcac     3000

tcacggtgtc aaagactgtt tagagtgctt tcccgtgtca gaatctcaac ccgtttctgt     3060

cgtcaaaaag gcgtatcaga aactgtgcta cattcatcac atcatgggaa aggtgccaga     3120

cgcttgcact gcttgcgacc tggtcaatgt ggacttggat gactgtgttt ctgaacaata     3180

aatgacttaa accaggtatg gctgccgatg gttatcttcc agattggctc gaggacaacc     3240

ttagtgaagg aattcgcgag tggtgggctt tgaaacctgg agcccctcaa cccaaggcaa     3300

atcaacaaca tcaagacaac gctcgaggtc ttgtgcttcc gggttacaaa taccttggac     3360

ccggcaacgg actcgacaag ggggagccgg tcaacgcagc agacgcggcg gccctcgagc     3420

acgacaaggc ctacgaccag cagctcaagg ccggagacaa cccgtacctc aagtacaacc     3480

acgccgacgc cgagttccag gagcggctca aagaagatac gtcttttggg ggcaacctcg     3540

ggcgagcagt cttccaggcc aaaaagaggc ttcttgaacc tcttggtctg gttgaggaag     3600

cggctaagac ggctcctgga aagaagaggc ctgtagagca gtctcctcag gaaccggact     3660

cctccgcggg tattggcaaa tcgggtgcac agcccgctaa aaagagactc aatttcggtc     3720

agactggcga cacagagtca gtcccagacc ctcaaccaat cggagaacct cccgcagccc     3780

cctcaggtgt gggatctctt acaatggctt caggtggtgg cgcaccagtg gcagacaata     3840

acgaaggtgc cgatggagtg ggtagttcct cgggaaattg gcattgcgat tcccaatggc     3900

tgggggacag agtcatcacc accagcaccc gaacctgggc cctgcccacc tacaacaatc     3960

acctctacaa gcaaatctcc aacagcacat ctggaggatc ttcaaatgac aacgcctact     4020

tcggctacag caccccctgg gggtattttg acttcaacag attccactgc cacttctcac     4080

cacgtgactg gcagcgactc atcaacaaca actggggatt ccggcctaag cgactcaact     4140

tcaagctctt caacattcag gtcaaagagg ttacggacaa caatggagtc aagaccatcg     4200

ccaataacct taccagcacg gtccaggtct tcacggactc agactatcag ctcccgtacg     4260

tgctcgggtc ggctcacgag ggctgcctcc cgccgttccc agcggacgtt ttcatgattc     4320

ctcagtacgg gtatctgacg cttaatgatg gaagccaggc cgtgggtcgt tcgtcctttt     4380

actgcctgga atatttcccg tcgcaaatgc taagaacggg taacaacttc cagttcagct     4440

acgagtttga gaacgtacct ttccatagca gctacgctca cagccaaagc ctggaccgac     4500

taatgaatcc actcatcgac caatacttgt actatctctc aaagactatt aacggttctg     4560

gacagaatca acaaacgcta aaattcagtg tggccggacc cagcaacatg gctgtccagg     4620

gaagaaacta catacctgga cccagctacc gacaacaacg tgtctcaacc actgtgactc     4680

aaaacaacaa cagcgaattt gcttggcctg gagcttcttc ttgggctctc aatggacgta     4740

atagcttgat gaatcctgga cctgctatgg ccagccacaa agaaggagag gaccgtttct     4800

ttcctttgtc tggatcttta atttttggca aacaaggaac tggaagagac aacgtggatg     4860

cggacaaagt catgataacc aacgaagaag aaattaaaac tactaacccg gtagcaacgg     4920

agtcctatgg acaagtggcc acaaaccacc agagtgccca agcacaggcg cagaccggct     4980

gggttcaaaa ccaaggaata cttccgggta tggtttggca ggacagagat gtgtacctgc     5040

aaggacccat ttgggccaaa attcctcaca cggacggcaa ctttcaccct tctccgctga     5100

tgggagggtt tggaatgaag cacccgcctc ctcagatcct catcaaaaac acacctgtac     5160

ctgcggatcc tccaacggcc ttcaacaagg acaagctgaa ctctttcatc acccagtatt     5220

ctactggcca agtcagcgtg gagatcgagt gggagctgca gaaggaaaac agcaagcgct     5280

ggaacccgga gatccagtac acttccaact attacaagtc taataatgtt gaatttgctg     5340

ttaatactga aggtgtatat agtgaacccc gccccattgg caccagatac ctgactcgta     5400

atctgtaatt gcttgttaat caataaaccg tttaattcgt ttcagttgaa ctttggtctc     5460

tgcgcgtcaa aagggcgaca caaaatttat tctaaatgca taataaatac tgataacatc     5520

ttatagtttg tattatattt tgtattatcg ttgacatgta taattttgat atcaaaaact     5580

gattttccct ttattatttt cgagatttat tttcttaatt ctctttaaca aactagaaat     5640

attgtatata caaaaaatca taaataatag atgaatagtt taattatagg tgttcatcaa     5700

tcgaaaaagc aacgtatctt atttaaagtg cgttgctttt ttctcattta taaggttaaa     5760

taattctcat atatcaagca aagtgacagg cgcccttaaa tattctgaca aatgctcttt     5820

ccctaaactc cccccataaa aaaacccgcc gaagcgggtt tttacgttat ttgcggatta     5880

acgattactc gttatcagaa ccgcccaggg ggcccgagct taagactggc cgtcgtttta     5940

caacacagaa agagtttgta gaaacgcaaa aaggccatcc gtcaggggcc ttctgcttag     6000

tttgatgcct ggcagttccc tactctcgcc ttccgcttcc tcgctcactg actcgctgcg     6060

ctcggtcgtt cggctgcggc gagcggtatc agctcactca aaggcggtaa tacggttatc     6120

cacagaatca ggggataacg caggaaagaa catgtgagca aaaggccagc aaaaggccag     6180

gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg ctccgccccc ctgacgagca     6240

tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg acaggactat aaagatacca     6300

ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg     6360

atacctgtcc gcctttctcc cttcgggaag cgtggcgctt tctcatagct cacgctgtag     6420

gtatctcagt tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt     6480

tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc cggtaagaca     6540

cgacttatcg ccactggcag cagccactgg taacaggatt agcagagcga ggtatgtagg     6600

cggtgctaca gagttcttga agtggtgggc taactacggc tacactagaa gaacagtatt     6660

tggtatctgc gctctgctga agccagttac cttcggaaaa agagttggta gctcttgatc     6720

cggcaaacaa accaccgctg gtagcggtgg tttttttgtt tgcaagcagc agattacgcg     6780

cagaaaaaaa ggatctcaag aagatccttt gatcttttct acggggtctg acgctcagtg     6840

gaacgacgcg cgcgtaactc acgttaaggg attttggtca tgagcttgcg ccgtcccgtc     6900

aagtcagcgt aatgctctgc tt                                              6922


<210>  22
<211>  128
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' ITR

<400>  22
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgc                                                               128


<210>  23
<211>  128
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' ITR

<400>  23
gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg cgacctttgg       60

tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaact ccatcactag      120

gggttcct                                                               128


<210>  24
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV true type

<400>  24

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ser Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Ser Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Met Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Asp Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  25
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV9

<400>  25

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  26
<211>  4417
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human SLC6A1 transcript variant 2 (isoform a)

<400>  26
gccctcggaa gaccgagaca gcggagaggt tgcgggtgag ctgcgctgag cccaggagcc       60

gaggagtcgg gagcgcagta gcgctgagcc cgagcccgag cggccccgcg tcccgagcgc      120

atcggagcgg ccgagccgcc cggatgcagc gcctgtcccg ggcagcgcag ccccggccgc      180

aggatctcac ccagggtggc agaaggaggc cttctggagc tgacccaccc ccgacgacca      240

tcagggtgcc cttgagccgc aaaactgctg tccacgtgga ccgggggtga catcgcacgt      300

ccatctgcca ggacccctgc gtccaaattc cgagacatgg cgaccaacgg cagcaaggtg      360

gccgacgggc agatctccac cgaggtcagc gaggcccctg tggccaatga caagcccaaa      420

accttggtgg tcaaggtgca gaagaaggcg gcagacctcc ccgaccggga cacgtggaag      480

ggccgcttcg acttcctcat gtcctgtgtg ggctatgcca tcggcctggg caacgtctgg      540

aggttcccct atctctgcgg gaaaaatggt gggggagcct tcctgatccc ctatttcctg      600

acactcatct ttgcgggggt cccactcttc ctgctggagt gctccctggg ccagtacacc      660

tccatcgggg ggctaggggt atggaagctg gctcctatgt tcaagggcgt gggccttgcg      720

gctgctgtgc tatcattctg gctgaacatc tactacatcg tcatcatctc ctgggccatt      780

tactacctgt acaactcctt caccacgaca ctgccgtgga aacagtgcga caacccctgg      840

aacacagacc gctgcttctc caactacagc atggtcaaca ctaccaacat gaccagcgct      900

gtggtggagt tctgggagcg caacatgcat cagatgacgg acgggctgga taagccaggt      960

cagatccgct ggccactggc catcacgctg gccatcgcct ggatccttgt gtatttctgt     1020

atctggaagg gtgttggctg gactggaaag gtggtctact tttcagccac atacccctac     1080

atcatgctga tcatcctgtt cttccgtgga gtgacgctgc ccggggccaa ggagggcatc     1140

ctcttctaca tcacacccaa cttccgcaag ctgtctgact ccgaggtgtg gctggatgcg     1200

gcaacccaga tcttcttctc atacgggctg ggcctggggt ccctgatcgc tctcgggagc     1260

tacaactctt tccacaacaa tgtctacagg gactccatca tcgtctgctg catcaattcg     1320

tgcaccagca tgttcgcagg attcgtcatc ttctccatcg tgggcttcat ggcccatgtc     1380

accaagaggt ccattgctga tgtggcggcc tcaggccccg ggctggcgtt cctggcatac     1440

ccagaggcgg tgacccagct gcctatctcc ccactctggg ccatcctctt cttctccatg     1500

ctgttgatgc tgggcattga cagccagttc tgcactgtgg agggcttcat cacagccctg     1560

gtggatgagt accccaggct cctccgcaac cgcagagagc tcttcattgc tgctgtctgc     1620

atcatctcct acctgatcgg tctctctaac atcactcagg ggggtattta tgtcttcaaa     1680

ctctttgact actactctgc cagtggcatg agcctgctgt tcctcgtgtt ctttgaatgt     1740

gtctctattt cctggtttta cggtgtcaac cgattctatg acaatatcca agagatggtt     1800

ggatccaggc cctgcatctg gtggaaactc tgctggtctt tcttcacacc aatcattgtg     1860

gcgggcgtgt tcattttcag tgctgtgcag atgacgccac tcaccatggg aaactatgtt     1920

ttccccaagt ggggccaggg tgtgggctgg ctgatggctc tgtcttccat ggtcctcatc     1980

cccgggtaca tggcctacat gttcctcacc ttaaagggct ccctgaagca gcgcatccaa     2040

gtcatggtcc agcccagcga agacatcgtt cgcccagaga atggtcctga gcagccccag     2100

gcgggcagct ccaccagcaa ggaggcctac atctagggtg ggggccactc accgacccga     2160

cactctcacc ccccgacctg gctgagtgcg accaccactt gatgtctgag gataccttcc     2220

atctcaacct acctcgagtg gcgagtccag acaccatcac cacgcagaga ggggaggtgg     2280

gaggacagtt agacccctgg gtgggccctg ccgtgggcaa ggatacccgg tggcttctgg     2340

cacctggcgg gctggtgacc tttttaatcc aggccccatc agcatcccac gatcggcctt     2400

ggtaaccgcc gcggtagatc atttttatcc cgccagggag tgtgatgcag gaagaccaca     2460

tgcgctcctg gcttttaaac ctgttcctga ctgttctctt actgccgaaa cccttgactg     2520

ttatctcgga ctttgcagga gttcctttcc ctccgaacgc tgctccatgc acaggaaaag     2580

ggcattttgt acaatgggga cttcccggga acgcttgctc ttaagtacca gaagccggcg     2640

gagctctggc tttcgtgttt ttggttttct ccttcccaag gcagctggat tgaaaaaaca     2700

aaacaaaaca aaaaaaccca ggggcgtcag tcgatattcc cagggccgct tctcctgcag     2760

tctgtggagc gtccttgtcc ccgccgccgg aatgaatgag cattctgcag cccgatgtcc     2820

ctgtcccctc ctcgccgggc cattctgatt ggacctggcc cagtgcaatc tgtccagaca     2880

agccctgctt gctggaaaac tgccacaagc acaattgatc tctttttatc gccattccag     2940

gggcctcagg tcctactggg gaaacttcct ataccggagc tccagtttct cttaagctgc     3000

ccaatttcac agagtacaaa atagttgtag gggaaatcaa ggtgaaggat ctgtccgaca     3060

gtcaagacgg atccacagta atctttcggt ctccttaaac taccaccctc gctgccaccc     3120

accccaagct gctgccgcct caccttcctt gaaatttctc agcgggagtc tcctcactgc     3180

cactaaaatc cacccagccc actaactgag gagctagtgt taatccagag aaccccccgc     3240

aatgtgcttc cgagattcag actgcttcat tgggaagtat gatttgttcc tttctggaat     3300

tgggctccgt ggtggcggcg gcacttcaag caaagacagt ttcttgcaag ctccagtagc     3360

tccgcgtgtc tcatttgcca ggaagatggg ttcccacgta gcaaatcgta cattgtgccc     3420

tgtagctcct tagctagtta gctcacaagc cgtgttttat gactaatcct taataactat     3480

ggtaaataac tgtgactgtg gggtttttaa tctcttgtca ttctcatcca aaagtgacca     3540

gcataccagt tcttgcaata agatattacc ctcagaatat taagcacatt attgtagaga     3600

aaaaaaaata tgtgtacaca tatgaacgca caacatgcac attcatcctc acatgtggca     3660

cgtaaggtct catttgatat tgtgtaggaa atctgaagcc ttttcctgag gtcatctgta     3720

aaatagtctc attgccaagg catccccagt gccagctggt gaatccatga tcaaaatgca     3780

tacgtattgt taaatgataa ggtttagaat gacaggaacc catcactgtg tctcatggtc     3840

ccacttcccc atctgtgtgt gaattccttt agactaaggg caggaagact tccagctttc     3900

tctttgttct tcaatgtgaa actgagacca agtctctcta agacaaatgc agtgtattta     3960

atgtttgtaa gcaattctaa gtgagatgtt tggcaagaaa tcccctaact gatttccatc     4020

caaacctacc ttatagagca caatattaag tgttgtacaa ttactgtgag aactgtgaat     4080

atgtgtaact tttttttagt atttgcccgg ggggaaaaag atattgtatt atcatatatg     4140

cttttttgca ataaggattt attctcagaa caccaagtaa atctatctct atataaaaaa     4200

tatatgtaat atatacatat tcaaagtata tacagagcct gttttaaaaa atacagtatt     4260

atttagtaaa attatctgtt ctatggacca aatgtaaaat atttataaat gaagatgcat     4320

tttaaatgtc tataaatggt gtcataacta gagcacgggc gttatgtaag tttctaagaa     4380

tttagaggat aaataataaa ggttctatga tatacaa                              4417


<210>  27
<211>  4227
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human SLC6A1 transcript variant 3 (isoform b)

<400>  27
gccctcggaa gaccgagaca gcggagaggt tgcgggtgag ctgcgctgag cccaggagcc       60

gaggagtcgg gagcgcagta gcgctgagcc cgagcccgag cggccccgcg tcccgagcgc      120

atcggagcgg ccgagccgcc cggatgcagc gcctgtcccg ggcagcgcag ccccggccgc      180

aggatctcac ccagggtggc agaaggaggc cttctggagc tgacccaccc ccgacgacca      240

tcagggtgcc cttgagccgc aaaactgctg tccacgtgga ccgggggtga catcgcacgt      300

ccatctgcca ggacccctgc gtccaaattc cgagacatgg cgaccaacgg cagcaaggtg      360

gccgacgggc agatctccac cgaggagcct tcctgatccc ctatttcctg acactcatct      420

ttgcgggggt cccactcttc ctgctggagt gctccctggg ccagtacacc tccatcgggg      480

ggctaggggt atggaagctg gctcctatgt tcaagggcgt gggccttgcg gctgctgtgc      540

tatcattctg gctgaacatc tactacatcg tcatcatctc ctgggccatt tactacctgt      600

acaactcctt caccacgaca ctgccgtgga aacagtgcga caacccctgg aacacagacc      660

gctgcttctc caactacagc atggtcaaca ctaccaacat gaccagcgct gtggtggagt      720

tctgggagcg caacatgcat cagatgacgg acgggctgga taagccaggt cagatccgct      780

ggccactggc catcacgctg gccatcgcct ggatccttgt gtatttctgt atctggaagg      840

gtgttggctg gactggaaag gtggtctact tttcagccac atacccctac atcatgctga      900

tcatcctgtt cttccgtgga gtgacgctgc ccggggccaa ggagggcatc ctcttctaca      960

tcacacccaa cttccgcaag ctgtctgact ccgaggtgtg gctggatgcg gcaacccaga     1020

tcttcttctc atacgggctg ggcctggggt ccctgatcgc tctcgggagc tacaactctt     1080

tccacaacaa tgtctacagg gactccatca tcgtctgctg catcaattcg tgcaccagca     1140

tgttcgcagg attcgtcatc ttctccatcg tgggcttcat ggcccatgtc accaagaggt     1200

ccattgctga tgtggcggcc tcaggccccg ggctggcgtt cctggcatac ccagaggcgg     1260

tgacccagct gcctatctcc ccactctggg ccatcctctt cttctccatg ctgttgatgc     1320

tgggcattga cagccagttc tgcactgtgg agggcttcat cacagccctg gtggatgagt     1380

accccaggct cctccgcaac cgcagagagc tcttcattgc tgctgtctgc atcatctcct     1440

acctgatcgg tctctctaac atcactcagg ggggtattta tgtcttcaaa ctctttgact     1500

actactctgc cagtggcatg agcctgctgt tcctcgtgtt ctttgaatgt gtctctattt     1560

cctggtttta cggtgtcaac cgattctatg acaatatcca agagatggtt ggatccaggc     1620

cctgcatctg gtggaaactc tgctggtctt tcttcacacc aatcattgtg gcgggcgtgt     1680

tcattttcag tgctgtgcag atgacgccac tcaccatggg aaactatgtt ttccccaagt     1740

ggggccaggg tgtgggctgg ctgatggctc tgtcttccat ggtcctcatc cccgggtaca     1800

tggcctacat gttcctcacc ttaaagggct ccctgaagca gcgcatccaa gtcatggtcc     1860

agcccagcga agacatcgtt cgcccagaga atggtcctga gcagccccag gcgggcagct     1920

ccaccagcaa ggaggcctac atctagggtg ggggccactc accgacccga cactctcacc     1980

ccccgacctg gctgagtgcg accaccactt gatgtctgag gataccttcc atctcaacct     2040

acctcgagtg gcgagtccag acaccatcac cacgcagaga ggggaggtgg gaggacagtt     2100

agacccctgg gtgggccctg ccgtgggcaa ggatacccgg tggcttctgg cacctggcgg     2160

gctggtgacc tttttaatcc aggccccatc agcatcccac gatcggcctt ggtaaccgcc     2220

gcggtagatc atttttatcc cgccagggag tgtgatgcag gaagaccaca tgcgctcctg     2280

gcttttaaac ctgttcctga ctgttctctt actgccgaaa cccttgactg ttatctcgga     2340

ctttgcagga gttcctttcc ctccgaacgc tgctccatgc acaggaaaag ggcattttgt     2400

acaatgggga cttcccggga acgcttgctc ttaagtacca gaagccggcg gagctctggc     2460

tttcgtgttt ttggttttct ccttcccaag gcagctggat tgaaaaaaca aaacaaaaca     2520

aaaaaaccca ggggcgtcag tcgatattcc cagggccgct tctcctgcag tctgtggagc     2580

gtccttgtcc ccgccgccgg aatgaatgag cattctgcag cccgatgtcc ctgtcccctc     2640

ctcgccgggc cattctgatt ggacctggcc cagtgcaatc tgtccagaca agccctgctt     2700

gctggaaaac tgccacaagc acaattgatc tctttttatc gccattccag gggcctcagg     2760

tcctactggg gaaacttcct ataccggagc tccagtttct cttaagctgc ccaatttcac     2820

agagtacaaa atagttgtag gggaaatcaa ggtgaaggat ctgtccgaca gtcaagacgg     2880

atccacagta atctttcggt ctccttaaac taccaccctc gctgccaccc accccaagct     2940

gctgccgcct caccttcctt gaaatttctc agcgggagtc tcctcactgc cactaaaatc     3000

cacccagccc actaactgag gagctagtgt taatccagag aaccccccgc aatgtgcttc     3060

cgagattcag actgcttcat tgggaagtat gatttgttcc tttctggaat tgggctccgt     3120

ggtggcggcg gcacttcaag caaagacagt ttcttgcaag ctccagtagc tccgcgtgtc     3180

tcatttgcca ggaagatggg ttcccacgta gcaaatcgta cattgtgccc tgtagctcct     3240

tagctagtta gctcacaagc cgtgttttat gactaatcct taataactat ggtaaataac     3300

tgtgactgtg gggtttttaa tctcttgtca ttctcatcca aaagtgacca gcataccagt     3360

tcttgcaata agatattacc ctcagaatat taagcacatt attgtagaga aaaaaaaata     3420

tgtgtacaca tatgaacgca caacatgcac attcatcctc acatgtggca cgtaaggtct     3480

catttgatat tgtgtaggaa atctgaagcc ttttcctgag gtcatctgta aaatagtctc     3540

attgccaagg catccccagt gccagctggt gaatccatga tcaaaatgca tacgtattgt     3600

taaatgataa ggtttagaat gacaggaacc catcactgtg tctcatggtc ccacttcccc     3660

atctgtgtgt gaattccttt agactaaggg caggaagact tccagctttc tctttgttct     3720

tcaatgtgaa actgagacca agtctctcta agacaaatgc agtgtattta atgtttgtaa     3780

gcaattctaa gtgagatgtt tggcaagaaa tcccctaact gatttccatc caaacctacc     3840

ttatagagca caatattaag tgttgtacaa ttactgtgag aactgtgaat atgtgtaact     3900

tttttttagt atttgcccgg ggggaaaaag atattgtatt atcatatatg cttttttgca     3960

ataaggattt attctcagaa caccaagtaa atctatctct atataaaaaa tatatgtaat     4020

atatacatat tcaaagtata tacagagcct gttttaaaaa atacagtatt atttagtaaa     4080

attatctgtt ctatggacca aatgtaaaat atttataaat gaagatgcat tttaaatgtc     4140

tataaatggt gtcataacta gagcacgggc gttatgtaag tttctaagaa tttagaggat     4200

aaataataaa ggttctatga tatacaa                                         4227


<210>  28
<211>  4156
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human SLC6A1 transcript variant 4 (isoform c)

<400>  28
gccctcggaa gaccgagaca gcggagaggt tgcgggtgag ctgcgctgag cccaggagcc       60

gaggagtcgg gagcgcagta gcgctgagcc cgagcccgag cggccccgcg tcccgagcgc      120

atcggagcgg ccgagccgcc cggatgcagc gcctgtcccg ggcagcgcag ccccggccgc      180

aggatctcac ccagggtggc agaaggaggc cttctggagc tgacccaccc ccgacgacca      240

tcagggtgag gcaactccaa ggtcctactc tctttctgtg cctgttaccc accccgtcct      300

cctagggtgc ccttgagccg caaaactgct gtccacgtgg accgggggtg acatcgcacg      360

tccatctgcc aggacccctg cgtccaaatt ccgagacatg gcgaccaacg gcagcaaggt      420

ggccgacggg cagatctcca ccgaggcgtg ggccttgcgg ctgctgtgct atcattctgg      480

ctgaacatct actacatcgt catcatctcc tgggccattt actacctgta caactccttc      540

accacgacac tgccgtggaa acagtgcgac aacccctgga acacagaccg ctgcttctcc      600

aactacagca tggtcaacac taccaacatg accagcgctg tggtggagtt ctgggagcgc      660

aacatgcatc agatgacgga cgggctggat aagccaggtc agatccgctg gccactggcc      720

atcacgctgg ccatcgcctg gatccttgtg tatttctgta tctggaaggg tgttggctgg      780

actggaaagg tggtctactt ttcagccaca tacccctaca tcatgctgat catcctgttc      840

ttccgtggag tgacgctgcc cggggccaag gagggcatcc tcttctacat cacacccaac      900

ttccgcaagc tgtctgactc cgaggtgtgg ctggatgcgg caacccagat cttcttctca      960

tacgggctgg gcctggggtc cctgatcgct ctcgggagct acaactcttt ccacaacaat     1020

gtctacaggg actccatcat cgtctgctgc atcaattcgt gcaccagcat gttcgcagga     1080

ttcgtcatct tctccatcgt gggcttcatg gcccatgtca ccaagaggtc cattgctgat     1140

gtggcggcct caggccccgg gctggcgttc ctggcatacc cagaggcggt gacccagctg     1200

cctatctccc cactctgggc catcctcttc ttctccatgc tgttgatgct gggcattgac     1260

agccagttct gcactgtgga gggcttcatc acagccctgg tggatgagta ccccaggctc     1320

ctccgcaacc gcagagagct cttcattgct gctgtctgca tcatctccta cctgatcggt     1380

ctctctaaca tcactcaggg gggtatttat gtcttcaaac tctttgacta ctactctgcc     1440

agtggcatga gcctgctgtt cctcgtgttc tttgaatgtg tctctatttc ctggttttac     1500

ggtgtcaacc gattctatga caatatccaa gagatggttg gatccaggcc ctgcatctgg     1560

tggaaactct gctggtcttt cttcacacca atcattgtgg cgggcgtgtt cattttcagt     1620

gctgtgcaga tgacgccact caccatggga aactatgttt tccccaagtg gggccagggt     1680

gtgggctggc tgatggctct gtcttccatg gtcctcatcc ccgggtacat ggcctacatg     1740

ttcctcacct taaagggctc cctgaagcag cgcatccaag tcatggtcca gcccagcgaa     1800

gacatcgttc gcccagagaa tggtcctgag cagccccagg cgggcagctc caccagcaag     1860

gaggcctaca tctagggtgg gggccactca ccgacccgac actctcaccc cccgacctgg     1920

ctgagtgcga ccaccacttg atgtctgagg ataccttcca tctcaaccta cctcgagtgg     1980

cgagtccaga caccatcacc acgcagagag gggaggtggg aggacagtta gacccctggg     2040

tgggccctgc cgtgggcaag gatacccggt ggcttctggc acctggcggg ctggtgacct     2100

ttttaatcca ggccccatca gcatcccacg atcggccttg gtaaccgccg cggtagatca     2160

tttttatccc gccagggagt gtgatgcagg aagaccacat gcgctcctgg cttttaaacc     2220

tgttcctgac tgttctctta ctgccgaaac ccttgactgt tatctcggac tttgcaggag     2280

ttcctttccc tccgaacgct gctccatgca caggaaaagg gcattttgta caatggggac     2340

ttcccgggaa cgcttgctct taagtaccag aagccggcgg agctctggct ttcgtgtttt     2400

tggttttctc cttcccaagg cagctggatt gaaaaaacaa aacaaaacaa aaaaacccag     2460

gggcgtcagt cgatattccc agggccgctt ctcctgcagt ctgtggagcg tccttgtccc     2520

cgccgccgga atgaatgagc attctgcagc ccgatgtccc tgtcccctcc tcgccgggcc     2580

attctgattg gacctggccc agtgcaatct gtccagacaa gccctgcttg ctggaaaact     2640

gccacaagca caattgatct ctttttatcg ccattccagg ggcctcaggt cctactgggg     2700

aaacttccta taccggagct ccagtttctc ttaagctgcc caatttcaca gagtacaaaa     2760

tagttgtagg ggaaatcaag gtgaaggatc tgtccgacag tcaagacgga tccacagtaa     2820

tctttcggtc tccttaaact accaccctcg ctgccaccca ccccaagctg ctgccgcctc     2880

accttccttg aaatttctca gcgggagtct cctcactgcc actaaaatcc acccagccca     2940

ctaactgagg agctagtgtt aatccagaga accccccgca atgtgcttcc gagattcaga     3000

ctgcttcatt gggaagtatg atttgttcct ttctggaatt gggctccgtg gtggcggcgg     3060

cacttcaagc aaagacagtt tcttgcaagc tccagtagct ccgcgtgtct catttgccag     3120

gaagatgggt tcccacgtag caaatcgtac attgtgccct gtagctcctt agctagttag     3180

ctcacaagcc gtgttttatg actaatcctt aataactatg gtaaataact gtgactgtgg     3240

ggtttttaat ctcttgtcat tctcatccaa aagtgaccag cataccagtt cttgcaataa     3300

gatattaccc tcagaatatt aagcacatta ttgtagagaa aaaaaaatat gtgtacacat     3360

atgaacgcac aacatgcaca ttcatcctca catgtggcac gtaaggtctc atttgatatt     3420

gtgtaggaaa tctgaagcct tttcctgagg tcatctgtaa aatagtctca ttgccaaggc     3480

atccccagtg ccagctggtg aatccatgat caaaatgcat acgtattgtt aaatgataag     3540

gtttagaatg acaggaaccc atcactgtgt ctcatggtcc cacttcccca tctgtgtgtg     3600

aattccttta gactaagggc aggaagactt ccagctttct ctttgttctt caatgtgaaa     3660

ctgagaccaa gtctctctaa gacaaatgca gtgtatttaa tgtttgtaag caattctaag     3720

tgagatgttt ggcaagaaat cccctaactg atttccatcc aaacctacct tatagagcac     3780

aatattaagt gttgtacaat tactgtgaga actgtgaata tgtgtaactt ttttttagta     3840

tttgcccggg gggaaaaaga tattgtatta tcatatatgc ttttttgcaa taaggattta     3900

ttctcagaac accaagtaaa tctatctcta tataaaaaat atatgtaata tatacatatt     3960

caaagtatat acagagcctg ttttaaaaaa tacagtatta tttagtaaaa ttatctgttc     4020

tatggaccaa atgtaaaata tttataaatg aagatgcatt ttaaatgtct ataaatggtg     4080

tcataactag agcacgggcg ttatgtaagt ttctaagaat ttagaggata aataataaag     4140

gttctatgat atacaa                                                     4156


<210>  29
<211>  4095
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human SLC6A1 transcript variant 5 (isoform c)

<400>  29
gccctcggaa gaccgagaca gcggagaggt tgcgggtgag ctgcgctgag cccaggagcc       60

gaggagtcgg gagcgcagta gcgctgagcc cgagcccgag cggccccgcg tcccgagcgc      120

atcggagcgg ccgagccgcc cggatgcagc gcctgtcccg ggcagcgcag ccccggccgc      180

aggatctcac ccagggtggc agaaggaggc cttctggagc tgacccaccc ccgacgacca      240

tcagggtgcc cttgagccgc aaaactgctg tccacgtgga ccgggggtga catcgcacgt      300

ccatctgcca ggacccctgc gtccaaattc cgagacatgg cgaccaacgg cagcaaggtg      360

gccgacgggc agatctccac cgaggcgtgg gccttgcggc tgctgtgcta tcattctggc      420

tgaacatcta ctacatcgtc atcatctcct gggccattta ctacctgtac aactccttca      480

ccacgacact gccgtggaaa cagtgcgaca acccctggaa cacagaccgc tgcttctcca      540

actacagcat ggtcaacact accaacatga ccagcgctgt ggtggagttc tgggagcgca      600

acatgcatca gatgacggac gggctggata agccaggtca gatccgctgg ccactggcca      660

tcacgctggc catcgcctgg atccttgtgt atttctgtat ctggaagggt gttggctgga      720

ctggaaaggt ggtctacttt tcagccacat acccctacat catgctgatc atcctgttct      780

tccgtggagt gacgctgccc ggggccaagg agggcatcct cttctacatc acacccaact      840

tccgcaagct gtctgactcc gaggtgtggc tggatgcggc aacccagatc ttcttctcat      900

acgggctggg cctggggtcc ctgatcgctc tcgggagcta caactctttc cacaacaatg      960

tctacaggga ctccatcatc gtctgctgca tcaattcgtg caccagcatg ttcgcaggat     1020

tcgtcatctt ctccatcgtg ggcttcatgg cccatgtcac caagaggtcc attgctgatg     1080

tggcggcctc aggccccggg ctggcgttcc tggcataccc agaggcggtg acccagctgc     1140

ctatctcccc actctgggcc atcctcttct tctccatgct gttgatgctg ggcattgaca     1200

gccagttctg cactgtggag ggcttcatca cagccctggt ggatgagtac cccaggctcc     1260

tccgcaaccg cagagagctc ttcattgctg ctgtctgcat catctcctac ctgatcggtc     1320

tctctaacat cactcagggg ggtatttatg tcttcaaact ctttgactac tactctgcca     1380

gtggcatgag cctgctgttc ctcgtgttct ttgaatgtgt ctctatttcc tggttttacg     1440

gtgtcaaccg attctatgac aatatccaag agatggttgg atccaggccc tgcatctggt     1500

ggaaactctg ctggtctttc ttcacaccaa tcattgtggc gggcgtgttc attttcagtg     1560

ctgtgcagat gacgccactc accatgggaa actatgtttt ccccaagtgg ggccagggtg     1620

tgggctggct gatggctctg tcttccatgg tcctcatccc cgggtacatg gcctacatgt     1680

tcctcacctt aaagggctcc ctgaagcagc gcatccaagt catggtccag cccagcgaag     1740

acatcgttcg cccagagaat ggtcctgagc agccccaggc gggcagctcc accagcaagg     1800

aggcctacat ctagggtggg ggccactcac cgacccgaca ctctcacccc ccgacctggc     1860

tgagtgcgac caccacttga tgtctgagga taccttccat ctcaacctac ctcgagtggc     1920

gagtccagac accatcacca cgcagagagg ggaggtggga ggacagttag acccctgggt     1980

gggccctgcc gtgggcaagg atacccggtg gcttctggca cctggcgggc tggtgacctt     2040

tttaatccag gccccatcag catcccacga tcggccttgg taaccgccgc ggtagatcat     2100

ttttatcccg ccagggagtg tgatgcagga agaccacatg cgctcctggc ttttaaacct     2160

gttcctgact gttctcttac tgccgaaacc cttgactgtt atctcggact ttgcaggagt     2220

tcctttccct ccgaacgctg ctccatgcac aggaaaaggg cattttgtac aatggggact     2280

tcccgggaac gcttgctctt aagtaccaga agccggcgga gctctggctt tcgtgttttt     2340

ggttttctcc ttcccaaggc agctggattg aaaaaacaaa acaaaacaaa aaaacccagg     2400

ggcgtcagtc gatattccca gggccgcttc tcctgcagtc tgtggagcgt ccttgtcccc     2460

gccgccggaa tgaatgagca ttctgcagcc cgatgtccct gtcccctcct cgccgggcca     2520

ttctgattgg acctggccca gtgcaatctg tccagacaag ccctgcttgc tggaaaactg     2580

ccacaagcac aattgatctc tttttatcgc cattccaggg gcctcaggtc ctactgggga     2640

aacttcctat accggagctc cagtttctct taagctgccc aatttcacag agtacaaaat     2700

agttgtaggg gaaatcaagg tgaaggatct gtccgacagt caagacggat ccacagtaat     2760

ctttcggtct ccttaaacta ccaccctcgc tgccacccac cccaagctgc tgccgcctca     2820

ccttccttga aatttctcag cgggagtctc ctcactgcca ctaaaatcca cccagcccac     2880

taactgagga gctagtgtta atccagagaa ccccccgcaa tgtgcttccg agattcagac     2940

tgcttcattg ggaagtatga tttgttcctt tctggaattg ggctccgtgg tggcggcggc     3000

acttcaagca aagacagttt cttgcaagct ccagtagctc cgcgtgtctc atttgccagg     3060

aagatgggtt cccacgtagc aaatcgtaca ttgtgccctg tagctcctta gctagttagc     3120

tcacaagccg tgttttatga ctaatcctta ataactatgg taaataactg tgactgtggg     3180

gtttttaatc tcttgtcatt ctcatccaaa agtgaccagc ataccagttc ttgcaataag     3240

atattaccct cagaatatta agcacattat tgtagagaaa aaaaaatatg tgtacacata     3300

tgaacgcaca acatgcacat tcatcctcac atgtggcacg taaggtctca tttgatattg     3360

tgtaggaaat ctgaagcctt ttcctgaggt catctgtaaa atagtctcat tgccaaggca     3420

tccccagtgc cagctggtga atccatgatc aaaatgcata cgtattgtta aatgataagg     3480

tttagaatga caggaaccca tcactgtgtc tcatggtccc acttccccat ctgtgtgtga     3540

attcctttag actaagggca ggaagacttc cagctttctc tttgttcttc aatgtgaaac     3600

tgagaccaag tctctctaag acaaatgcag tgtatttaat gtttgtaagc aattctaagt     3660

gagatgtttg gcaagaaatc ccctaactga tttccatcca aacctacctt atagagcaca     3720

atattaagtg ttgtacaatt actgtgagaa ctgtgaatat gtgtaacttt tttttagtat     3780

ttgcccgggg ggaaaaagat attgtattat catatatgct tttttgcaat aaggatttat     3840

tctcagaaca ccaagtaaat ctatctctat ataaaaaata tatgtaatat atacatattc     3900

aaagtatata cagagcctgt tttaaaaaat acagtattat ttagtaaaat tatctgttct     3960

atggaccaaa tgtaaaatat ttataaatga agatgcattt taaatgtcta taaatggtgt     4020

cataactaga gcacgggcgt tatgtaagtt tctaagaatt tagaggataa ataataaagg     4080

ttctatgata tacaa                                                      4095


<210>  30
<211>  6946
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV true type DNA sequence

<400>  30
tttcaatatt attgaagcat ttatcagggt tattgtctca tgagcggata catatttgaa       60

tgtatttaga aaaataaaca aataggggtc agtgttacaa ccaattaacc aattctgaac      120

attatcgcga gcccatttat acctgaatat ggctcataac accccttgtt tgcctggcgg      180

cagtagcgcg gtggtcccac ctgaccccat gccgaactca gaagtgaaac gccgtagcgc      240

cgatggtagt gtggggactc cccatgcgag agtagggaac tgccaggcat caaataaaac      300

gaaaggctca gtcgaaagac tgggcctttc gcccgggcta attagggggt gtcgcccttc      360

gctgaagtcc tgtattagag gtcacgtgag tgttttgcga cattttgcga caccatgtgg      420

tcacgctggg tatttaagcc cgagtgagca cgcagggtct ccattttgaa gcgggaggtt      480

tgaacgcgca gccgccatgc cggggtttta cgagattgtg attaaggtcc ccagcgacct      540

tgacgagcat ctgcccggca tttctgacag ctttgtgaac tgggtggccg agaaggaatg      600

ggagttgccg ccagattctg acatggatct gaatctgatt gagcaggcac ccctgaccgt      660

ggccgagaag ctgcagcgcg actttctgac ggaatggcgc cgtgtgagta aggccccgga      720

ggcccttttc tttgtgcaat ttgagaaggg agagagctac ttccacatgc acgtgctcgt      780

ggaaaccacc ggggtgaaat ccatggtttt gggacgtttc ctgagtcaga ttcgcgaaaa      840

actgattcag agaatttacc gcgggatcga gccgactttg ccaaactggt tcgcggtcac      900

aaagaccaga aatggcgccg gaggcgggaa caaggtggtg gatgagtgct acatccccaa      960

ttacttgctc cccaaaaccc agcctgagct ccagtgggcg tggactaata tggaacagta     1020

tttaagcgcc tgtttgaatc tcacggagcg taaacggttg gtggcgcagc atctgacgca     1080

cgtgtcgcag acgcaggagc agaacaaaga gaatcagaat cccaattctg atgcgccggt     1140

gatcagatca aaaacttcag ccaggtacat ggagctggtc gggtggctcg tggacaaggg     1200

gattacctcg gagaagcagt ggatccagga ggaccaggcc tcatacatct ccttcaatgc     1260

ggcctccaac tcgcggtccc aaatcaaggc tgccttggac aatgcgggaa agattatgag     1320

cctgactaaa accgcccccg actacctggt gggccagcag cccgtggagg acatttccag     1380

caatcggatt tataaaattt tggaactaaa cgggtacgat ccccaatatg cggcttccgt     1440

ctttctggga tgggccacga aaaagttcgg caagaggaac accatctggc tgtttgggcc     1500

tgcaactacc gggaagacca acatcgcgga ggccatagcc cacactgtgc ccttctacgg     1560

gtgcgtaaac tggaccaatg agaactttcc cttcaacgac tgtgtcgaca agatggtgat     1620

ctggtgggag gaggggaaga tgaccgccaa ggtcgtggag tcggccaaag ccattctcgg     1680

aggaagcaag gtgcgcgtgg accagaaatg caagtcctcg gcccagatag acccgactcc     1740

cgtgatcgtc acctccaaca ccaacatgtg cgccgtgatt gacgggaact caacgacctt     1800

cgaacaccag cagccgttgc aagaccggat gttcaaattt gaactcaccc gccgtctgga     1860

tcatgacttt gggaaggtca ccaagcagga agtcaaagac tttttccggt gggcaaagga     1920

tcacgtggtt gaggtggagc atgaattcta cgtcaaaaag ggtggagcca agaaaagacc     1980

cgcccccagt gacgcagata taagtgagcc caaacgggtg cgcgagtcag ttgcgcagcc     2040

atcgacgtca gacgcggaag cttcgatcaa ctacgcagac aggtaccaaa acaaatgttc     2100

tcgtcacgtg ggcatgaatc tgatgctgtt tccctgcaga caatgcgaga gaatgaatca     2160

gaattcaaat atctgcttca ctcacggaca gaaagactgt ttagagtgct ttcccgtgtc     2220

agaatctcaa cccgtttctg tcgtcaaaaa ggcgtatcag aaactgtgct acattcatca     2280

tatcatggga aaggtgccag acgcttgcac tgcctgcgat ctggtcaatg tggatttgga     2340

tgactgcatc tttgaacaat aaatgattta aatcaggtat ggctgccgat ggttatcttc     2400

cagattggct cgaggacact ctctctgaag gaataagaca gtggtggaag ctcaaacctg     2460

gcccaccacc accaaagccc gcagagcggc ataaggacga cagcaggggt cttgtgcttc     2520

ctgggtacaa gtacctcgga cccttcaacg gactcgacaa gggagagccg gtcaacgagg     2580

cagacgccgc ggccctcgag cacgacaaag cctacgaccg gcagctcgac agcggagaca     2640

acccgtacct caagtacaac cacgccgacg cggagtttca ggagcgcctt aaagaagata     2700

cgtcttttgg gggcaacctc ggacgagcag tcttccaggc gaaaaagagg atccttgaac     2760

ctctgggcct ggttgaggaa cctgttaaga cggctccggg aaaaaagagg ccggtagagc     2820

actctcctgc cgagccagac tcctcctcgg gaaccggaaa gagcggccag cagcctgcaa     2880

gaaaaagatt gaattttggt cagactggag acgcagactc agtacctgac ccccagcctc     2940

tcggacagcc accagcagcc ccctctggtc tgggaactaa tacgatggct agcggcagtg     3000

gcgcaccaat ggcagacaat aacgagggcg ccgacggagt gggtaattcc tcgggaaatt     3060

ggcattgcga ttccacatgg atgggcgaca gagtcatcac caccagcacc cgaacctggg     3120

ccctgcccac ctacaacaac cacctctaca aacaaatttc cagccaatca ggagcctcga     3180

acgacaatca ctactttggc tacagcaccc cttgggggta ttttgacttc aacagattcc     3240

actgccactt ttcaccacgt gactggcaaa gactcatcaa caacaactgg ggattccgac     3300

ccaagagact cagcttcaag ctctttaaca ttcaagtcaa agaggtcacg cagaatgacg     3360

gtacgacgac gattgccaat aaccttacca gcacggttca ggtgtttact gactcggagt     3420

accagctccc gtacgtcctc ggctcggcgc atcaaggatg cctcccgccg ttcccagcag     3480

acgtcttcat ggtgccacag tatggatacc tcaccctgaa caacgggagt caggcagtag     3540

gacgctcttc attttactgc ctggagtact ttccttctca gatgctgcgt accggaaaca     3600

actttacctt cagctacact tttgaggacg ttcctttcca cagcagctac gctcacagcc     3660

agagtctgga ccgtctcatg aatcctctca tcgaccagta cctgtattac ttgagcagaa     3720

caaacactcc aagtggaacc accacgatgt caaggcttca gttttctcag gccggagcga     3780

gtgacattcg ggaccagtct aggaactggc ttcctggacc ctgttaccgc cagcagcgag     3840

tatcaaagac agccgcggat aacaacaaca gtgactactc gtggactgga gctaccaagt     3900

accacctcaa tggcagagac tctctggtga atccgggccc ggccatggca agccacaagg     3960

acgatgaaga aaagtacttt cctcagagcg gggttctcat ctttgggaag caagactcag     4020

gcaaaacaaa tgtggacatt gaaaaggtca tgattacaga cgaagaggaa atcaggacaa     4080

ccaatcccgt ggctacggag cagtatggtt ctgtatctac caacctccag agcggcaaca     4140

cccaagcagc taccagcgat gtcaacacac aaggcgttct tccaggcatg gtctggcagg     4200

acagagatgt gtaccttcag gggcccatct gggcaaagat tccacacacg gacggacatt     4260

ttcacccctc tcccctcatg ggtggattcg gacttaaaca ccctcctcca cagattctca     4320

tcaagaacac cccggtacct gcgaatcctt cgaccacctt cagtgcggca aagtttgctt     4380

ccttcatcac acagtactcc acgggacagg tcagcgtgga gatcgagtgg gagctgcaga     4440

aggaaaacag caaacgctgg aatcccgaaa ttcagtacac ttccaactac aacaagtctg     4500

ttaatgtgga ctttactgtg gacactaatg gcgtgtattc agagcctcgc cccattggca     4560

ccagatacct gactcgtaat ctgtaattgc ttgttaatca ataaaccgtt taattcgttt     4620

cagttgaact ttggtctctg cgcgtcaaaa gggcgacaca aaatttattc taaatgcata     4680

ataaatactg ataacatctt atagtttgta ttatattttg tattatcgtt gacatgtata     4740

atttttctag agcggccgca gatctcagct ggatatcaaa aactgatttt ccctttatta     4800

ttttcgagat ttattttctt aattctcttt aacaaactag aaatattgta tatacaaaaa     4860

atcataaata atagatgaat agtttaatta taggtgttca tcaatcgaaa aagcaacgta     4920

tcttatttaa agtgcgttgc ttttttctca tttataaggt taaataattc tcatatatca     4980

agcaaagtga caggcgccct taaatattct gacaaatgct ctttccctaa actcccccca     5040

taaaaaaacc cgccgaagcg ggtttttacg ttatttgcgg attaacgatt actcgttatc     5100

agaaccgccc agggggcccg agcttaagac tggccgtcgt tttacaacac agaaagagtt     5160

tgtagaaacg caaaaaggcc atccgtcagg ggccttctgc ttagtttgat gcctggcagt     5220

tccctactct cgccttccgc ttcctcgctc actgactcgc tgcgctcggt cgttcggctg     5280

cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt tatccacaga atcaggggat     5340

aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc     5400

gcgttgctgg cgtttttcca taggctccgc ccccctgacg agcatcacaa aaatcgacgc     5460

tcaagtcaga ggtggcgaaa cccgacagga ctataaagat accaggcgtt tccccctgga     5520

agctccctcg tgcgctctcc tgttccgacc ctgccgctta ccggatacct gtccgccttt     5580

ctcccttcgg gaagcgtggc gctttctcat agctcacgct gtaggtatct cagttcggtg     5640

taggtcgttc gctccaagct gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc     5700

gccttatccg gtaactatcg tcttgagtcc aacccggtaa gacacgactt atcgccactg     5760

gcagcagcca ctggtaacag gattagcaga gcgaggtatg taggcggtgc tacagagttc     5820

ttgaagtggt gggctaacta cggctacact agaagaacag tatttggtat ctgcgctctg     5880

ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa acaaaccacc     5940

gctggtagcg gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct     6000

caagaagatc ctttgatctt ttctacgggg tctgacgctc agtggaacga cgcgcgcgta     6060

actcacgtta agggattttg gtcatgagct tgcgccgtcc cgtcaagtca gcgtaatgct     6120

ctgcttttag aaaaactcat cgagcatcaa atgaaactgc aatttattca tatcaggatt     6180

atcaatacca tatttttgaa aaagccgttt ctgtaatgaa ggagaaaact caccgaggca     6240

gttccatagg atggcaagat cctggtatcg gtctgcgatt ccgactcgtc caacatcaat     6300

acaacctatt aatttcccct cgtcaaaaat aaggttatca agtgagaaat caccatgagt     6360

gacgactgaa tccggtgaga atggcaaaag tttatgcatt tctttccaga cttgttcaac     6420

aggccagcca ttacgctcgt catcaaaatc actcgcatca accaaaccgt tattcattcg     6480

tgattgcgcc tgagcgaggc gaaatacgcg atcgctgtta aaaggacaat tacaaacagg     6540

aatcgagtgc aaccggcgca ggaacactgc cagcgcatca acaatatttt cacctgaatc     6600

aggatattct tctaatacct ggaacgctgt ttttccgggg atcgcagtgg tgagtaacca     6660

tgcatcatca ggagtacgga taaaatgctt gatggtcgga agtggcataa attccgtcag     6720

ccagtttagt ctgaccatct catctgtaac atcattggca acgctacctt tgccatgttt     6780

cagaaacaac tctggcgcat cgggcttccc atacaagcga tagattgtcg cacctgattg     6840

cccgacatta tcgcgagccc atttataccc atataaatca gcatccatgt tggaatttaa     6900

tcgcggcctc gacgtttccc gttgaatatg gctcatattc ttcctt                    6946


<210>  31
<211>  1800
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse SLC6A1

<400>  31
atggcgactg acaacagcaa ggtggctgat gggcagatct ctactgaggt cagcgaggcc       60

cctgtggcca gcgacaagcc caaaaccctg gtagtcaagg tgcagaagaa ggccggggac      120

ctccctgacc gggacacatg gaagggacgc ttcgacttcc tcatgtcctg cgtgggctat      180

gccatcggcc tgggcaatgt gtggaggttc ccttacctct gtgggaaaaa cggtggcggg      240

gccttcctaa tcccatattt cctgacgctc atctttgcgg gtgttcctct cttccttttg      300

gagtgctccc taggccagta cacctccatt gggggcctgg gcgtatggaa gctggcgccc      360

atgttcaagg gtgtgggcct cgcggcagct gtgctgtcct tctggctgaa catctactac      420

atcgtcatca tctcctgggc catctactac ctgtacaact ccttcaccac gaccctgcca      480

tggaaacagt gtgacaaccc gtggaacact gaccgctgct tctccaacta cagcctggtc      540

aataccacca acatgaccag cgccgtggtg gagttctggg agcgcaacat gcaccagatg      600

acagatggac tggacaagcc aggacagatc cgctggcctc tggccatcac actggccatt      660

gcctgggtgc tcgtgtattt ctgcatctgg aagggtgttg gttggactgg aaaggtggtc      720

tacttctcag ccacgtaccc ctacatcatg cttatcatcc tgttcttccg tggagtgacg      780

cttcccgggg ccaaggaggg gatcctcttc tacatcacac ccaacttccg aaagctgtct      840

gattctgagg tgtggcttga cgccgccacc cagatcttct tctcctacgg gctgggcctg      900

gggtccctga ttgctctggg aagctacaac tctttccaca acaatgtgta cagggactcc      960

atcatcgttt gctgcatcaa ctcctgcacc agcatgtttg ccggattcgt catcttctcc     1020

atcgtgggct tcatggctca tgtcaccaag aggtccatag ctgatgtggc agcctcaggc     1080

ccggggctgg cattcttggc gtaccctgag gctgtgacac agctacccat ctctcccctc     1140

tgggctatcc tcttcttctc catgctgctg atgctgggca ttgacagcca gttctgtacc     1200

gtggagggct tcatcactgc cctggtggac gagtacccca gacttctccg caatcgccgt     1260

gaactcttca ttgctgccgt gtgcatcgtg tcctacctga ttggcctgtc taacatcacc     1320

cagggtggca tttatgtctt caaactgttt gattattact ctgccagcgg catgagcttg     1380

ctgttcctgg ttttcttcga gtgtgtctcc atttcctggt tttatggtgt caaccggttc     1440

tatgacaaca tccaggagat ggttggctcc aggccctgca tctggtggaa gctgtgctgg     1500

tcctttttca cacccatcat tgtggcgggc gtgtttctct tcagtgctgt gcagatgaca     1560

ccactcacca tgggaagcta tgttttcccc aagtggggcc agggcgtggg ctggctcatg     1620

gctctgtcct ccatggtgct catccccggg tacatggctt acatgttcct caccctgaag     1680

ggctccctga agcagcgtct ccaggtcatg attcagccca gtgaagatat tgtgcgccct     1740

gagaatggcc ctgagcagcc gcaggctggc agctcagcca gcaaggaggc ctacatctag     1800


<210>  32
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Myc tag

<400>  32
gagcagaaac tcatctcaga agaggatctg                                        30


<210>  33
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HA tag

<400>  33
tacccttacg atgtaccgga ttacgca                                           27


<210>  34
<211>  2000
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MECP2 intron

<400>  34
gcgctccctc ctctcggaga gagggctgtg gtaaaacccg tccggaaatt ggccgccgct       60

gccgccaccg ccgccgccgc cgccgcgccg agcggaggag gaggaggagg cgaggaggag      120

agactgtgag tgggaccgcc aaggccgcgg gcggggaccc ttgctggggg gcgggtaggg      180

gcgggacgtg gcgcgggagg ggcccgcggg gtcgggcgac acggctggcg gttggcgtcc      240

ctcctctcta ccctccccct ccctctgccg ccggtggtgg ctttctccac tcgtctcccg      300

caatcgcgag cgacggttct cagcgcgatc tccctggagc caccttcgat tgacgccctc      360

ccgctgcccg ccccatctgt gcgcatccta ggccccagct gtgcaagcgc ccttgtcgtc      420

tgggcttcgc cagttggggc tgcgcgcgct cctgcccttc ttggggcttt gggcctcggc      480

actgtcgcgc gcccgcggtc ccggcctctc cctggatcgc gctgtcccct tctccctcgc      540

gcgcccccac tcccgttact tgctcccccc tcacacacac agactggcgc gcgtgcgcag      600

tccatctccc gttgggagag tgcgccacaa gggctcctga gctcttaccc ccatctctgg      660

gttttgctcc ctcctcctcc tctcccattc cgtgactttt tgcccccact gcaagcgagt      720

cggtccatca gctccattcc ccacttggca ggaacaagtt gagggttatt gtccacccac      780

aaaaaggact agacattttg ttcctaggtc ccacaactca tcataaagag ttggttgtag      840

ttctcatcag gaaccgtggg caagggactg tgcgttcctc agcactcgaa gctcttccgt      900

gagaccttgc ccgcagggtg ctctggttct ttggggttgc tgtgctgtgg cttcggaatt      960

tgagcgtctt cccaccctcc ctcccctccc ttcgccagcg ttctgtctac aagaaagaat     1020

aggcaggtgt ccttggatat cgtagttgct aatcgcctat acactgttct attacacctt     1080

tctgctaagg atagggtttt tggttttggt tttggttttg ttccccaccc tccagtttgg     1140

tttagttttg gttttggcat ttagggtttt ttggggggga gtaatatctt gtggtaaaga     1200

cccatctgac ccaagatacc ttttttctca tactggaacc ctaggcagca gttgctattt     1260

ccctgagtta gcaatagttt tacagtattt tgaggccttt tgtccataat tctcacggaa     1320

tccctcaggg atcagattag ctgctgttgg gatcaggaaa ttgggttaca ccgctgaaat     1380

ctcttgctgg ggcccttgtt ttgaattgga aagtcaggag gctggaacga aggctcacaa     1440

gttaacagtg ccagctgctc ttccagaagc cctggattca gtcccaccaa tccatcgcgg     1500

gtcacaacca tctgtaactt cagtcccaag gggtccgaag ccctcttctg gctttgccct     1560

attattttat ttatcttatc tgtttttgtc ttgtcatctg gcaagcccag ggggccattg     1620

ggtgcaactt ataaactgac ttctgtatct taagaagcca accatacagt gcttacattc     1680

cagaaaaaaa atctgccact ttaacagcac tagaactagg gtttagagaa gtatcataaa     1740

ggtcaaatat ctttgaccaa tatcaccagc aacctaaagc tgttaagaaa tctttgggcc     1800

ccagcttgac ccaaggatac agtatcctag ggaagttacc aaaatcagag atagtatgca     1860

gcagccaggg gtctcatgtg tggcactcaa gctcacctat actcactact gtgcagacag     1920

ctgtgttctc tgtaatactt acatatttgt ttaatacttc agggaggaaa agtcagaaga     1980

ccaggatctc cagggcctca                                                 2000


<210>  35
<211>  231
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EF1a promoter

<400>  35
ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga gaagttgggg       60

ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt      120

gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta tataagtgca      180

ctagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca g               231


