                         SEQUENCE LISTING

<110>  University of Georgia Research Foundation, Inc.
 
<120>  COMPOSITIONS AND METHODS OF TREATMENT FOR SARS-COV-2 THROUGH 
       PAPAIN PROTEASE INHIBITION

<130>  222105-2010

<150>  63/086,137
<151>  2020-10-01

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  315
<212>  PRT
<213>  Bat SARS CoV Rf1/2004

<400>  1

Glu Val Lys Thr Ile Lys Val Phe Thr Thr Val Asp Asn Thr Asn Leu 
1               5                   10                  15      


His Thr Gln Leu Val Asp Met Ser Met Thr Tyr Gly Gln His Phe Gly 
            20                  25                  30          


Pro Thr Tyr Leu Asp Gly Ala Asp Val Thr Lys Val Lys Pro His Val 
        35                  40                  45              


Asn His Glu Gly Lys Thr Phe Phe Val Leu Pro Ser Asp Asp Thr Leu 
    50                  55                  60                  


Arg Ser Glu Ala Phe Glu Tyr Tyr His Thr Leu Asp Glu Ser Phe Leu 
65                  70                  75                  80  


Gly Arg Tyr Met Ser Ala Leu Asn His Thr Lys Lys Trp Lys Phe Pro 
                85                  90                  95      


Gln Val Gly Gly Leu Thr Ser Ile Lys Trp Ala Asp Asn Asn Cys Tyr 
            100                 105                 110         


Leu Ser Ser Val Leu Leu Ala Leu Gln Gln Ile Glu Val Lys Phe Asn 
        115                 120                 125             


Ala Pro Ala Leu Gln Glu Ala Tyr Tyr Arg Ala Arg Ala Gly Asp Ala 
    130                 135                 140                 


Ala Asn Phe Cys Ala Leu Ile Leu Ala Tyr Ser Asn Lys Thr Val Gly 
145                 150                 155                 160 


Glu Leu Gly Asp Val Arg Glu Thr Met Thr His Leu Leu Gln His Ala 
                165                 170                 175     


Asn Leu Glu Ser Ala Lys Arg Val Leu Asn Leu Val Cys Lys His Cys 
            180                 185                 190         


Gly Gln Lys Thr Thr Thr Leu Met Gly Val Glu Ala Val Met Tyr Met 
        195                 200                 205             


Gly Thr Leu Ser Tyr Asp Glu Leu Lys Ala Gly Val Ser Ile Pro Cys 
    210                 215                 220                 


Val Cys Gly Arg Asp Ala Thr Gln Tyr Leu Val Gln Gln Glu Ser Ser 
225                 230                 235                 240 


Phe Val Met Met Ser Ala Pro Pro Ala Glu Tyr Lys Leu Gln Gln Gly 
                245                 250                 255     


Thr Phe Leu Cys Ala Asn Glu Tyr Thr Gly Asn Tyr Gln Cys Gly His 
            260                 265                 270         


Tyr Thr His Ile Thr Ala Lys Glu Thr Leu Tyr Arg Ile Asp Gly Ala 
        275                 280                 285             


His Leu Thr Lys Met Ser Glu Tyr Lys Gly Pro Val Thr Asp Val Phe 
    290                 295                 300                 


Tyr Lys Glu Thr Ser Tyr Thr Thr Thr Ile Lys 
305                 310                 315 


<210>  2
<211>  315
<212>  PRT
<213>  SARS CoV-2

<400>  2

Glu Val Arg Thr Ile Lys Val Phe Thr Thr Val Asp Asn Ile Asn Leu 
1               5                   10                  15      


His Thr Gln Val Val Asp Met Ser Met Thr Tyr Gly Gln Gln Phe Gly 
            20                  25                  30          


Pro Thr Tyr Leu Asp Gly Ala Asp Val Thr Lys Ile Lys Pro His Asn 
        35                  40                  45              


Ser His Glu Gly Lys Thr Phe Tyr Val Leu Pro Asn Asp Asp Thr Leu 
    50                  55                  60                  


Arg Val Glu Ala Phe Glu Tyr Tyr His Thr Thr Asp Pro Ser Phe Leu 
65                  70                  75                  80  


Gly Arg Tyr Met Ser Ala Leu Asn His Thr Lys Lys Trp Lys Tyr Pro 
                85                  90                  95      


Gln Val Asn Gly Leu Thr Ser Ile Lys Trp Ala Asp Asn Asn Cys Tyr 
            100                 105                 110         


Leu Ala Thr Ala Leu Leu Thr Leu Gln Gln Ile Glu Leu Lys Phe Asn 
        115                 120                 125             


Pro Pro Ala Leu Gln Asp Ala Tyr Tyr Arg Ala Arg Ala Gly Glu Ala 
    130                 135                 140                 


Ala Asn Phe Cys Ala Leu Ile Leu Ala Tyr Cys Asn Lys Thr Val Gly 
145                 150                 155                 160 


Glu Leu Gly Asp Val Arg Glu Thr Met Ser Tyr Leu Phe Gln His Ala 
                165                 170                 175     


Asn Leu Asp Ser Cys Lys Arg Val Leu Asn Val Val Cys Lys Thr Cys 
            180                 185                 190         


Gly Gln Gln Gln Thr Thr Leu Lys Gly Val Glu Ala Val Met Tyr Met 
        195                 200                 205             


Gly Thr Leu Ser Tyr Glu Gln Phe Lys Lys Gly Val Gln Ile Pro Cys 
    210                 215                 220                 


Thr Cys Gly Lys Gln Ala Thr Lys Tyr Leu Val Gln Gln Glu Ser Pro 
225                 230                 235                 240 


Phe Val Met Met Ser Ala Pro Pro Ala Gln Tyr Glu Leu Lys His Gly 
                245                 250                 255     


Thr Phe Thr Cys Ala Ser Glu Tyr Thr Gly Asn Tyr Gln Cys Gly His 
            260                 265                 270         


Tyr Lys His Ile Thr Ser Lys Glu Thr Leu Tyr Cys Ile Asp Gly Ala 
        275                 280                 285             


Leu Leu Thr Lys Ser Ser Glu Tyr Lys Gly Pro Ile Thr Asp Val Phe 
    290                 295                 300                 


Tyr Lys Glu Asn Ser Tyr Thr Thr Thr Ile Lys 
305                 310                 315 


<210>  3
<211>  315
<212>  PRT
<213>  SARS CoV

<400>  3

Glu Val Lys Thr Ile Lys Val Phe Thr Thr Val Asp Asn Thr Asn Leu 
1               5                   10                  15      


His Thr Gln Leu Val Asp Met Ser Met Thr Tyr Gly Gln Gln Phe Gly 
            20                  25                  30          


Pro Thr Tyr Leu Asp Gly Ala Asp Val Thr Lys Ile Lys Pro His Val 
        35                  40                  45              


Asn His Glu Gly Lys Thr Phe Phe Val Leu Pro Ser Asp Asp Thr Leu 
    50                  55                  60                  


Arg Ser Glu Ala Phe Glu Tyr Tyr His Thr Leu Asp Glu Ser Phe Leu 
65                  70                  75                  80  


Gly Arg Tyr Met Ser Ala Leu Asn His Thr Lys Lys Trp Lys Phe Pro 
                85                  90                  95      


Gln Val Gly Gly Leu Thr Ser Ile Lys Trp Ala Asp Asn Asn Cys Tyr 
            100                 105                 110         


Leu Ser Ser Val Leu Leu Ala Leu Gln Gln Leu Glu Val Lys Phe Asn 
        115                 120                 125             


Ala Pro Ala Leu Gln Glu Ala Tyr Tyr Arg Ala Arg Ala Gly Asp Ala 
    130                 135                 140                 


Ala Asn Phe Cys Ala Leu Ile Leu Ala Tyr Ser Asn Lys Thr Val Gly 
145                 150                 155                 160 


Glu Leu Gly Asp Val Arg Glu Thr Met Thr His Leu Leu Gln His Ala 
                165                 170                 175     


Asn Leu Glu Ser Ala Lys Arg Val Leu Asn Val Val Cys Lys His Cys 
            180                 185                 190         


Gly Gln Lys Thr Thr Thr Leu Thr Gly Val Glu Ala Val Met Tyr Met 
        195                 200                 205             


Gly Thr Leu Ser Tyr Asp Asn Leu Lys Thr Gly Val Ser Ile Pro Cys 
    210                 215                 220                 


Val Cys Gly Arg Asp Ala Thr Gln Tyr Leu Val Gln Gln Glu Ser Ser 
225                 230                 235                 240 


Phe Val Met Met Ser Ala Pro Pro Ala Glu Tyr Lys Leu Gln Gln Gly 
                245                 250                 255     


Thr Phe Leu Cys Ala Asn Glu Tyr Thr Gly Asn Tyr Gln Cys Gly His 
            260                 265                 270         


Tyr Thr His Ile Thr Ala Lys Glu Thr Leu Tyr Arg Ile Asp Gly Ala 
        275                 280                 285             


His Leu Thr Lys Met Ser Glu Tyr Lys Gly Pro Val Thr Asp Val Phe 
    290                 295                 300                 


Tyr Lys Glu Thr Ser Tyr Thr Thr Thr Ile Lys 
305                 310                 315 


<210>  4
<211>  315
<212>  PRT
<213>  Civet SARS CoV SZ16/2003

<400>  4

Glu Val Lys Thr Ile Lys Val Phe Thr Thr Val Asp Asn Thr Asn Leu 
1               5                   10                  15      


His Thr Gln Leu Val Asp Met Ser Met Thr Tyr Gly Gln Gln Phe Gly 
            20                  25                  30          


Pro Thr Tyr Leu Asp Gly Ala Asp Val Thr Lys Ile Lys Pro His Val 
        35                  40                  45              


Asn His Glu Gly Lys Thr Phe Phe Val Leu Pro Ser Asp Asp Thr Leu 
    50                  55                  60                  


Arg Ser Glu Ala Phe Glu Tyr Tyr His Thr Leu Asp Glu Ser Phe Leu 
65                  70                  75                  80  


Gly Arg Tyr Met Ser Ala Leu Asn His Thr Lys Lys Trp Lys Phe Pro 
                85                  90                  95      


Gln Val Gly Gly Leu Thr Ser Ile Lys Trp Ala Asp Asn Asn Cys Tyr 
            100                 105                 110         


Leu Ser Ser Val Leu Leu Ala Leu Gln Gln Ile Glu Val Lys Phe Asn 
        115                 120                 125             


Ala Pro Ala Leu Gln Glu Ala Tyr Tyr Arg Ala Arg Ala Gly Asp Ala 
    130                 135                 140                 


Ala Asn Phe Cys Ala Leu Ile Leu Ala Tyr Ser Asn Lys Thr Val Gly 
145                 150                 155                 160 


Glu Leu Gly Asp Val Arg Glu Thr Met Thr His Leu Leu Gln His Ala 
                165                 170                 175     


Asn Leu Glu Ser Ala Lys Arg Val Leu Asn Val Val Cys Lys His Cys 
            180                 185                 190         


Gly Gln Lys Thr Thr Thr Leu Thr Gly Val Glu Ala Val Met Tyr Met 
        195                 200                 205             


Gly Thr Leu Ser Tyr Asp Asn Leu Lys Thr Gly Val Ser Ile Pro Cys 
    210                 215                 220                 


Val Cys Gly Arg Asp Ala Thr Gln Tyr Leu Val Gln Gln Glu Ser Ser 
225                 230                 235                 240 


Phe Val Met Met Ser Ala Pro Pro Ala Glu Tyr Lys Leu Gln Gln Gly 
                245                 250                 255     


Thr Phe Leu Cys Ala Asn Glu Tyr Thr Gly Asn Tyr Gln Cys Gly His 
            260                 265                 270         


Tyr Thr His Ile Thr Ala Lys Glu Thr Leu Tyr Arg Ile Asp Gly Ala 
        275                 280                 285             


His Leu Thr Lys Met Ser Glu Tyr Lys Gly Pro Val Thr Asp Val Phe 
    290                 295                 300                 


Tyr Lys Glu Thr Ser Tyr Thr Thr Thr Ile Lys 
305                 310                 315 


<210>  5
<211>  315
<212>  PRT
<213>  Bat SARS CoV HKU3.2

<400>  5

Glu Val Lys Thr Ile Lys Val Phe Thr Thr Val Asp Asn Thr Asn Leu 
1               5                   10                  15      


His Thr His Ile Val Asp Met Ser Met Thr Tyr Gly Gln Gln Phe Gly 
            20                  25                  30          


Pro Thr Tyr Leu Asp Gly Ala Asp Val Thr Lys Ile Lys Pro His Val 
        35                  40                  45              


Asn His Glu Gly Lys Thr Phe Phe Val Leu Pro Ser Asp Asp Thr Leu 
    50                  55                  60                  


Arg Ser Glu Ala Phe Glu Tyr Tyr His Thr Ile Asp Glu Ser Phe Leu 
65                  70                  75                  80  


Gly Arg Tyr Met Ser Ala Leu Asn His Thr Lys Lys Trp Lys Phe Pro 
                85                  90                  95      


Gln Val Gly Gly Leu Thr Ser Ile Lys Trp Ala Asp Asn Asn Cys Tyr 
            100                 105                 110         


Leu Ser Ser Val Leu Leu Ala Leu Gln Gln Val Glu Val Lys Phe Asn 
        115                 120                 125             


Ala Pro Ala Leu Gln Glu Ala Tyr Tyr Arg Ala Arg Ala Gly Asp Ala 
    130                 135                 140                 


Ala Asn Phe Cys Ala Leu Ile Leu Ala Tyr Ser Asn Lys Thr Val Gly 
145                 150                 155                 160 


Glu Leu Gly Asp Val Arg Glu Thr Met Thr His Leu Leu Gln His Ala 
                165                 170                 175     


Asn Leu Glu Ser Ala Lys Arg Val Leu Asn Val Val Cys Lys His Cys 
            180                 185                 190         


Gly Gln Lys Thr Thr Thr Leu Lys Gly Val Glu Ala Val Met Tyr Met 
        195                 200                 205             


Gly Thr Leu Ser Tyr Asp Glu Leu Lys Thr Gly Val Ser Ile Pro Cys 
    210                 215                 220                 


Val Cys Gly Arg Asn Ala Thr Gln Tyr Leu Val Gln Gln Glu Ser Ser 
225                 230                 235                 240 


Phe Val Met Met Ser Ala Pro Pro Ala Glu Tyr Lys Leu Gln Gln Gly 
                245                 250                 255     


Ala Phe Leu Cys Ala Asn Glu Tyr Thr Gly Asn Tyr Gln Cys Gly His 
            260                 265                 270         


Tyr Thr His Ile Thr Ala Lys Glu Thr Leu Tyr Arg Val Asp Gly Ala 
        275                 280                 285             


His Leu Thr Lys Met Ser Glu Tyr Lys Gly Pro Val Thr Asp Val Phe 
    290                 295                 300                 


Tyr Lys Glu Thr Ser Tyr Thr Thr Ala Ile Lys 
305                 310                 315 


<210>  6
<211>  315
<212>  PRT
<213>  Bat SARS CoV Rm1/2004

<400>  6

Glu Val Arg Thr Ile Lys Val Phe Thr Thr Val Asp Asn Thr Asn Leu 
1               5                   10                  15      


His Thr Gln Ile Val Asp Met Ser Met Thr Tyr Gly Gln Gln Phe Gly 
            20                  25                  30          


Pro Thr Tyr Leu Asp Gly Ala Asp Val Thr Lys Ile Lys Pro His Ala 
        35                  40                  45              


Lys His Glu Gly Lys Thr Phe Phe Val Leu Pro Ser Asp Asp Thr Leu 
    50                  55                  60                  


Arg Ser Glu Ala Phe Glu Tyr Tyr His Thr Leu Asp Glu Ser Phe Leu 
65                  70                  75                  80  


Gly Arg Tyr Met Ser Ala Leu Asn His Thr Lys Lys Trp Lys Phe Pro 
                85                  90                  95      


Gln Ile Gly Gly Leu Thr Ser Ile Lys Trp Ala Asp Asn Asn Cys Tyr 
            100                 105                 110         


Leu Ser Ser Val Leu Leu Ala Leu Gln Gln Ile Glu Val Lys Phe Asn 
        115                 120                 125             


Ala Pro Ala Leu Gln Glu Ala Tyr Tyr Arg Ala Arg Ala Gly Asp Ala 
    130                 135                 140                 


Ala Asn Phe Cys Ala Leu Ile Leu Ala Tyr Ser Asn Arg Thr Val Gly 
145                 150                 155                 160 


Glu Leu Gly Asp Val Arg Glu Thr Met Thr His Leu Leu Gln His Ala 
                165                 170                 175     


Asn Leu Glu Ser Ala Lys Arg Val Leu Asn Val Val Cys Lys Thr Cys 
            180                 185                 190         


Gly Gln Lys Ser Thr Thr Leu Thr Gly Val Glu Ala Val Met Tyr Met 
        195                 200                 205             


Gly Thr Leu Ser Tyr Glu Glu Leu Lys Thr Gly Val Thr Ile Pro Cys 
    210                 215                 220                 


Ile Cys Gly Arg Asp Ala Thr Gln Tyr Leu Val Gln Gln Glu Ser Ser 
225                 230                 235                 240 


Phe Val Met Met Ser Ala Pro Pro Ser Glu Tyr Thr Leu Gln Gln Gly 
                245                 250                 255     


Ala Phe Leu Cys Ala Asn Glu Tyr Thr Gly Ser Tyr Gln Cys Gly His 
            260                 265                 270         


Tyr Thr His Val Thr Val Lys Glu Thr Leu Tyr Arg Ile Asp Gly Ala 
        275                 280                 285             


Tyr Leu Thr Lys Met Ser Glu Tyr Lys Gly Pro Val Thr Asp Val Phe 
    290                 295                 300                 


Tyr Lys Glu Ile Ser Tyr Thr Thr Thr Ile Lys 
305                 310                 315 


<210>  7
<211>  321
<212>  PRT
<213>  Human beta-CoV EMC/2012 (MERS)

<400>  7

Gln Leu Thr Ile Glu Val Leu Val Thr Val Asp Gly Val Asn Phe Arg 
1               5                   10                  15      


Thr Val Val Leu Asn Asn Lys Asn Thr Tyr Arg Ser Gln Leu Gly Cys 
            20                  25                  30          


Val Phe Phe Asn Gly Ala Asp Ile Ser Asp Thr Ile Pro Asp Glu Lys 
        35                  40                  45              


Gln Asn Gly His Ser Leu Tyr Leu Ala Asp Asn Leu Thr Ala Asp Glu 
    50                  55                  60                  


Thr Lys Ala Leu Lys Glu Leu Tyr Gly Pro Val Asp Pro Thr Phe Leu 
65                  70                  75                  80  


His Arg Phe Tyr Ser Leu Lys Ala Ala Val His Gly Trp Lys Met Val 
                85                  90                  95      


Val Cys Asp Lys Val Arg Ser Leu Lys Leu Ser Asp Asn Asn Cys Tyr 
            100                 105                 110         


Leu Asn Ala Val Ile Met Thr Leu Asp Leu Leu Lys Asp Ile Lys Phe 
        115                 120                 125             


Val Ile Pro Ala Leu Gln His Ala Phe Met Lys His Lys Gly Gly Asp 
    130                 135                 140                 


Ser Thr Asp Phe Ile Ala Leu Ile Met Ala Tyr Gly Asn Cys Thr Phe 
145                 150                 155                 160 


Gly Ala Pro Asp Asp Ala Ser Arg Leu Leu His Thr Val Leu Ala Lys 
                165                 170                 175     


Ala Glu Leu Cys Cys Ser Ala Arg Met Val Trp Arg Glu Trp Cys Asn 
            180                 185                 190         


Val Cys Gly Ile Lys Asp Val Val Leu Gln Gly Leu Lys Ala Cys Cys 
        195                 200                 205             


Tyr Val Gly Val Gln Thr Val Glu Asp Leu Arg Ala Arg Met Thr Tyr 
    210                 215                 220                 


Val Cys Gln Cys Gly Gly Glu Arg His Arg Gln Leu Val Glu His Thr 
225                 230                 235                 240 


Thr Pro Trp Leu Leu Leu Ser Gly Thr Pro Asn Glu Lys Leu Val Thr 
                245                 250                 255     


Thr Ser Thr Ala Pro Asp Phe Val Ala Phe Asn Val Phe Gln Gly Ile 
            260                 265                 270         


Glu Thr Ala Val Gly His Tyr Val His Ala Arg Leu Lys Gly Gly Leu 
        275                 280                 285             


Ile Leu Lys Phe Asp Ser Gly Thr Val Ser Lys Thr Ser Asp Trp Lys 
    290                 295                 300                 


Cys Lys Val Thr Asp Val Leu Phe Pro Gly Gln Lys Tyr Ser Ser Asp 
305                 310                 315                 320 


Cys 
    


<210>  8
<211>  315
<212>  PRT
<213>  Human CoV NL63

<400>  8

Phe Val Val Glu Ser Asn Val Met Asp Val Asn Asp Cys Phe Lys Asn 
1               5                   10                  15      


Asp Asn Val Val Leu Lys Ile Thr Glu Asp Gly Ile Asn Val Lys Asp 
            20                  25                  30          


Val Val Val Glu Ser Ser Lys Ser Leu Gly Lys Gln Leu Gly Val Val 
        35                  40                  45              


Ser Asp Gly Val Asp Ser Phe Glu Gly Val Leu Pro Ile Asn Thr Asp 
    50                  55                  60                  


Thr Val Leu Ser Val Ala Pro Glu Val Asp Trp Val Ala Phe Tyr Gly 
65                  70                  75                  80  


Phe Glu Lys Ala Ala Leu Phe Ala Ser Leu Asp Val Lys Pro Tyr Gly 
                85                  90                  95      


Tyr Pro Asn Asp Phe Val Gly Gly Phe Arg Val Leu Gly Thr Thr Asp 
            100                 105                 110         


Asn Asn Cys Trp Val Asn Ala Thr Cys Ile Ile Leu Gln Tyr Leu Lys 
        115                 120                 125             


Pro Thr Phe Lys Ser Lys Gly Leu Asn Val Leu Trp Asn Lys Phe Val 
    130                 135                 140                 


Thr Gly Asp Val Gly Pro Phe Val Ser Phe Ile Tyr Phe Ile Thr Met 
145                 150                 155                 160 


Ser Ser Lys Gly Gln Lys Gly Asp Ala Glu Glu Ala Leu Ser Lys Leu 
                165                 170                 175     


Ser Glu Tyr Leu Ile Ser Asp Ser Ile Val Thr Leu Glu Gln Tyr Ser 
            180                 185                 190         


Thr Cys Asp Ile Cys Lys Ser Thr Val Val Glu Val Lys Ser Ala Ile 
        195                 200                 205             


Val Cys Ala Ser Val Leu Lys Asp Gly Cys Asp Val Gly Phe Cys Pro 
    210                 215                 220                 


His Arg His Lys Leu Arg Ser Arg Val Lys Phe Val Asn Gly Arg Val 
225                 230                 235                 240 


Val Ile Thr Asn Val Gly Glu Pro Ile Ile Ser Gln Pro Ser Lys Leu 
                245                 250                 255     


Leu Asn Gly Ile Ala Tyr Thr Thr Phe Ser Gly Ser Phe Asp Asn Gly 
            260                 265                 270         


His Tyr Val Val Tyr Asp Ala Ala Asn Asn Ala Val Tyr Asp Gly Ala 
        275                 280                 285             


Arg Leu Phe Ser Ser Asp Leu Ser Thr Leu Ala Val Thr Ala Ile Val 
    290                 295                 300                 


Val Val Gly Gly Cys Val Thr Ser Asn Val Pro 
305                 310                 315 


