                         SEQUENCE LISTING

<110>  University of Massachusetts
 
<120>  MARF/MFN MODULATORS AND USES THEREOF

<130>  U0120.70150WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 63/182,508
<151>  2021-04-30

<150>  US 63/087,111
<151>  2020-10-02

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  16357
<212>  DNA
<213>  Homo Sapiens

<400>  1
ctgagcgccg cgggcctgcg ccattgagga gcggcgggga ggaaacgccg cgcagcgccg       60

ggctggggcg ggcggcccgg gacaccgaca gatttttctg tgaccatgaa agagagaaat      120

aaagaatgat ccatgatttc taaacacctt ttcctgagga tatagtcatg ttggaaggcc      180

ttgtagcctg ggttctcaat acctatttgg gaaaatatgt caataacctg aacactgacc      240

agctctcagt tgcacttctc aaaggtgctg ttgaattaga aaacttgcca ttaaagaaag      300

atgccttgaa agaattggaa ttaccatttg aagtcaaagc tggcttcatt gggaaagtaa      360

cccttcagat tcccttttat cgcccccatg tggacccttg ggtgatctcc atctccagcc      420

ttcacttaat tggagcccca gagaaaatac aggatttcaa tgatgaaaag gagaagctgt      480

tggaaaggga acgtaagaaa gcactacttc aagccctgga ggagaaatgg aagaatgacc      540

gccagcagaa aggggagtcc tattggtatt cagttaccgc ctccgtagtt acaaggattg      600

tggagaatat tgaattaaaa attcaagatg tccatttacg ctttgaagat ggtgtcacca      660

atccctccca tccttttgct tttggcatct gcattaagaa tgtgtccatg caaaatgctg      720

tgaatgagcc tgtacagaaa ctaatgcgga aaaagcaatt agacgtagca gaatttagca      780

tctattggga tgtcgattgc actttactgg gggatttgcc tcagatggag ttacaggagg      840

ccatggccag gagcatggag agtcgcagcc atcactacgt cctggagcct gtgtttgcat      900

ctgctctttt gaagagaaac tgctccaaga agcccctgcg gtctcggcac agtccccgta      960

ttgattgtga tattcagctg gagaccattc ccttgaaact ctctcagctg caataccggc     1020

aaatcatgga attcctcaag gagctggaac gaaaggagag gcaggtgaag ttccgaaggt     1080

ggaaacccaa ggtggcgata tctaagaact gccgagaatg gtggtatttt gctttgaatg     1140

ctaacttgta tgagatcaga gagcagagga aacgttgcac ctgggacttt atgttgcacc     1200

gcgctcgtga tgctgtatct tacactgaca aatatttcaa caagttaaaa ggaggcctgc     1260

tgtccacaga tgacaaggag gaaatgtgtc ggattgaaga ggaacagagc tttgaggaat     1320

tgaagatttt gcgtgaactg gttcatgatc gatttcacaa acaggaagaa ctagcagaga     1380

gtctgcggga gcctcagttt gattctccag gagcctgtcc gggagcccca gaacccggtg     1440

gaggcagtgg gatgctgcag tatctccagt cctggtttcc tggatggggt ggctggtacg     1500

ggcagcagac cccagaaggg aatgtggttg agggactgtc agcagagcaa caggagcagt     1560

ggattcctga agagatcctg ggcactgagg agttttttga ccccactgca gatgcctcgt     1620

gtatgaacac gtatacaaag cgagatcatg tctttgccaa actgaatttg cagttgcagc     1680

gaggtacagt gactctgtta cacaaggagc aaggaactcc tcaaatgaat gaaagtgctt     1740

tcatgcagct cgagttttca gatgtaaaac ttctagcaga gtctcttcct cgaagaaatt     1800

cctcgttgct ttcagtccgg ttgggtggac tgtttcttcg agacctggct acagaaggaa     1860

ctatgtttcc tcttctagtc ttccctaatc cacaaaaaga agttggcaga gtctcacaat     1920

cttttggtct acaaactaca tctgcagaca gaagtgatca ttacccagct gcagatccag     1980

atggccccgt ttttgagatg ctgtatgaga gaaatccggc gcacagccac tttgagaggc     2040

ggctcaatgt cagcacaagg cccttgaaca tcatatacaa tccgcaggcc attaaaaaag     2100

tagcagactt tttctacaag ggaaaggttc atacctcagg ttttggttat cagtctgaac     2160

ttgagctgag agtggctgaa gctgcccgaa gacaatataa caagctgaag atgcagacca     2220

aggcagaaat ccggcaaact cttgatcgtt tgctagtggg tgatttcatt gaggagagta     2280

aacgatggac cgtgcggctg gatatttctg cccctcaggt gatatttcct gatgatttca     2340

aattcaagaa tcctgtgtta gttgtcgtgg atctaggaag aatgcttttg acgaacaccc     2400

aagataactc caggaggaaa agtagggatg ggtcagcatc tgaagagacc cagtttagtg     2460

atgatgaata taagaccccc ctggccacac ctcctaacac cccacctccc gagtcaagca     2520

gcagcaacgg agagaaaaca cctccctttt ctggagttga gttcagtgaa gaacagcttc     2580

aagcacattt aatgagcaca aagatgtatg agaggtactc gctgtcattt atggacctcc     2640

agatcatggt tggacgagtg aaagacaatt ggaagcatgt ccaggatatt gacgtgggac     2700

caacacatgt ggtagagaag ttcaacgttc acctacagtt agagcgtcga ttgatttata     2760

cttcagatcc caaatatcca ggagccgtgc tctcaggcaa cttaccagac ttaaaaatcc     2820

acattaatga agataaaata tctgcactaa agaattgctt tgctctcctc accaccccag     2880

aaatgaaaac ttctgacact cagattaaag aaaagatttt tccccaggag gagcagcggg     2940

gaagtttgca agactccgta atgaatttaa cccagagcat tgtgttgttg gagcagcata     3000

cccgcgaggt tctggtggag tcgcagctcc tcctggcgga atttaaagtg aactgtatgc     3060

agcttggtgt tgagagcaat ggccggtaca tttctgtgct caaggtgttt ggtaccaatg     3120

ctcactttgt gaagaggcct tatgatgctg aagtctccct aactgttcat ggtttgctcc     3180

tggtggatac catgcagaca tatggtgctg attttgacct tttgatggct tcacataaga     3240

acttgagctt tgatattcca acgggaagcc ttcgggatag cagggcccag tctcctgtct     3300

ctggaccgaa tgtggcccac ttaactgatg gagctacact gaacgaccga tcagctacta     3360

gtgtttcact tgacaaaatt cttaccaaag agcaagagtc ccttattaag ttggaatatc     3420

agtttgtgag ttcagagtgc ccatcgatga atttagacag tactcttcag gtgatttccc     3480

tacaggtgaa taatttagat attatcctca atccagagac gattgtggag ctaattggtt     3540

ttcttcaaaa atcctttccc aaggaaaaag atgatttaag tcctcaacct ttaatgactg     3600

attttgaaag aagcttcaga gaacaaggaa cttaccagtc tacatatgaa caaaacactg     3660

aggttgcagt ggaaatccat aggctgaact tactgcttct tcggacagtg ggcatggcaa     3720

atagagagaa atatggcaga aaaattgcaa ctgcaagtat aggtggcacc aaagttaatg     3780

tctcaatggg tagcacgttt gacatgaatg gttctcttgg ctgtttacag cttatggatt     3840

tgacacaaga taacgttaaa aaccagtatg ttgtcagcat tgggaattct gtaggctatg     3900

aaaatatcat cagtgatatt ggctactttg aatctgtgtt tgtcagaatg gaagatgcag     3960

ccctcactga agctttgagt ttcacgtttg ttgagagatc taaacaggag tgttttctca     4020

acctgaagat ggcttcttta cattataacc actctgctaa gtttttgaag gagttgacgt     4080

tatccatgga tgaactggaa gaaaattttc gaggtatgct gaaaagcgca gccaccaaag     4140

tcaccacagt actagctacc aagactgccg agtatagcga gatggtatcg ctctttgaaa     4200

ctccaaggaa gactcgggaa ccctttatct tagaggaaaa tgaaatatat gggtttgacc     4260

tagcttcgtc tcatttggac actgtaaagc taatcttgaa cataaacatt gaatcaccag     4320

ttgtttctat ccctcggaag ccggggagtc ctgagttgtt ggtgggacac ttgggacaga     4380

tattcatcca gaattttgtg gcgggagatg atgaatccag aagtgaccgt ctgcaggtgg     4440

aaatcaagga cattaaactg tattctttga attgcaccca gttggcaggt agagaagctg     4500

ttgggtctga aggaagccgg atgttttgcc caccttccgg gtctggcagt gccaacagtc     4560

aggaggaagc tcatttcaca cgacatgatt tctttgaatc tttgcataga ggtcaagctt     4620

ttcacatcct gaacaacacc accattcagt ttaaactgga gaagatccct atagagagag     4680

aatctgaatt gactttttct cttagcccag atgacctggg aacttctagc atcatgaaga     4740

ttgaaggaaa atttgtcaat ccagttcagg tggtgttagc aaagcatgta tatgagcagg     4800

ttttacaaac cctggacaat ctcgtgtaca gtgaagatct gaataagtat ccagccagtg     4860

ctacctcctc cccttgccct gattctcctc tgcctcccct cagtacctgt ggagaatctt     4920

ctgttgaaag gaaggagaat ggattgttca gccactccag cctttctaac acctctcaga     4980

agtcattgtc agtgaaggaa gtcaaatcct ttactcagat tcaagccacc ttttgtatat     5040

cagagcttca ggttcagcta agtggagatc tgactttggg ggcccaaggt cttgtgagct     5100

taaagtttca ggactttgag gtggaattca gtaaagacca tccccagact ttatctattc     5160

agattgccct gcattctctg ctgatggagg acttattgga gaagaatcca gattctaaat     5220

ataagaacct gatggtgtct cgaggagccc ctaagccatc tagtttagca caaaaagaat     5280

acctttctca gtcttgcccc tcagtgtcca atgtggaata tcctgatatg cctcggtctc     5340

tcccttccca catggaagaa gctcctaatg tcttccagtt gtatcaaagg cccacctctg     5400

cgtcccggaa aaagcaaaag gaagtccaag acaaggacta tcccttgacc ccacctcctt     5460

ctccaacagt ggatgagccc aagatacttg ttggaaagag taaatttgat gattccttag     5520

tccacatcaa catattcttg gtagataaga aacatccaga attctcttcc agttacaatc     5580

gagttaaccg gagcattgat gttgatttta attgcttgga tgtgctgatc acactgcaaa     5640

cctgggttgt gatattagac ttttttggaa tcggctccac tgcagacaac cacgcaatga     5700

ggctgcctcc tgagggcatt ctgcacaacg tgaagttgga gccacatgcc tccatggagt     5760

ctggacttca ggatccagtg aacaccaaac tggatctcaa ggttcattca ctttctctag     5820

tgctgaataa gaccaccagt gagcttgcca aagcaaatgt gtccaaatta gtagcacacc     5880

tggaaatgat tgagggagac ctggccttac agggcagcat tgggagtctg tctctaagtg     5940

acctcacatg ccatggagag ttctacagag aacggttcac taccagtggt gaagaagcac     6000

tcatcttcca gacttttaaa tacggacggc ctgaccctct gctccggaga gaacacgaca     6060

ttcgcgtgag cctccggatg gcctctgtgc agtatgtgca tactcagcgt ttccaggcag     6120

aggtggtggc cttcattcag catttcactc agctgcagga tgtcttaggg cgccagcgag     6180

ctgctattga ggggcagacg gtgagagatc aagcccagcg ctgttcacgg gttctcctgg     6240

atattgaggc tggtgctccc gttctcttga tcccagaaag ttccagatca aataatctga     6300

ttgtagcaaa tttggggaag ttgaaagtca aaaataagtt tctgtttgct ggttttcctg     6360

gcaccttttc cctacaagat aaggaatctg tgccttcagc ttccccaacg ggtattccca     6420

aacacagtct gaggaaaacg acaagcacgg aggagcccag gggaacccat tcccaggggc     6480

agttcacgat gcctcttgct ggaatgagcc taggaagcct gaagagtgag tttgtgccca     6540

gtacctccac caagcagcaa gggccgcaac ccacactgtc tgttggccaa gagtccagta     6600

gtccagaaga ccatgtctgc ctgctggatt gcgttgtcgt ggatctccag gacatggaca     6660

tctttgctgc agagagacat ccgagagaat actcgaaggc accagaggat agtagtggag     6720

atctgatctt cccttcctat tttgtgcgac agacaggagg aagcctctta accgagcctt     6780

gtaggctgaa attgcaggtg gaaaggaatt tggacaaaga aataagtcat actgtgccag     6840

acatatctat ccatggcaat ctctcctcag tccactgctc tctggatctg tataaataca     6900

agctgatccg cggcttatta gagaacaacc tgggagaacc catagaggaa tttatgcggc     6960

cttatgattt acaagatcca agaattcata ctgtcctgag tggagaagtg tacacctgta     7020

tgtgcttcct cattgatatg gtgaatgtaa gtctggagct taaagatcca aaaagaaaag     7080

aaggtgctgg gtccctagcc agatttgact tcaagaaatg caaactgctc tatgaaagtt     7140

tttccaacca aaccaagtcc attaacttgg tttcccattc catgatggct tttgacaccc     7200

gttatgctgg gcagaagacc agccctggca tgacgaatgt gttcagctgt atctttcagc     7260

ccgctaagaa cagcagcacc acccaagggt ccattcagat tgaactacat ttcagatcta     7320

ccaaggattc ctcctgcttt acagtagttc tcaacaatct ccgtgtgttt ctcatatttg     7380

actggctact gttagtccat gattttctcc acactcccag tgatattaag aaacaaaatc     7440

atgttactcc ttctcgccac cgtaactcta gcagcgaatc tgctatagtt cccaaaactg     7500

tgaagagtgg agtagttacc aagcggtctt cccttcctgt gtccaatgaa aggcacctgg     7560

aggtcaaggt caatgtaaca ggtacggagt ttgtggtcat tgaagatgtg tcctgcttcg     7620

acaccaatgc cattattctg aaaggcacca cagtgctcac ctataagccc cggtttgttg     7680

atcgcccctt ttcaggaagt ttgtttggca ttgaggtgtt ttcatgccga ctagggaatg     7740

agcatgatac agctctttca attgtggatc ccgtacaaat tcaaatggag ttggtgggga     7800

attcttctta tcaaaatagt tcaggattga tggatgcatt caatagtgaa gatttcccac     7860

ctgtcctgga gattcagtta caagccctgg atatcagact ctcctataat gatgttcagc     7920

tgtttcttgc cattgcaaaa tccatcccag agcaagctaa tgctgcagtg ccagactcag     7980

tggccctgga gtcagactcc gttggcactt accttccagg tgcatctcgc gttggagagg     8040

aaatcagaga agggacaaga cacaccttag atcctgtctt ggagttacag ctggctaggc     8100

tgcaggagct gggattcagc atggatgatt gtcgcaaagc tcttttggcg tgtcaaggcc     8160

aattgaaaaa ggcagcaagt tggttgttta agaatgcgga acctctgaag tctctttcct     8220

tggcctccac cagccgagat agcccagggg ctgtggcagc gccattgatc tctggcgtgg     8280

agatcaaagc tgagagtgtg tgcatctgtt tcatcgatga ctgcatggat tgtgatgttc     8340

ctctcgctga actcaccttt tcccgtctga attttcttca gcgtgtaaga actagccctg     8400

aaggctatgc ccacttcacc ctttctggag attattataa ccgtgctctt tcaggctggg     8460

agccatttat tgagccttgg ccatgctctg tatcctggca acagcaggca gctagtcgtc     8520

tccatcctcc tcgactgaag ctagaagcca aggccaaacc tcgtttggat atcaatatca     8580

cttctgtgct aattgaccag tatgtaagta ccaaggaatc gtggatggca gattactgta     8640

aagatgacaa ggacatagag tcagctaaat cagaagactg gatgggctct tcggtggatc     8700

ctccatgttt tggacaaagc ctcccccttg tctaccttag aactaggagt acagccagtc     8760

tgactaacct agagcaccag atctatgcta gagcagaggt gaaaaccccc aagcgccggc     8820

agccatttgt cccctttgct ctgaggaacc acacggggtg cactttgtgg tttgccaccc     8880

tgaccaccac acccaccaga gctgcactct ctcacagtgg gagtccaggg gtagttccag     8940

aagggaacgg aacatttctc gatgatactc acaatgttag tgaatggcga gaagtcctta     9000

caggtgaaga gattcccttt gaatttgaag caagaggaaa gttaagacac agacacaccc     9060

atgacctccg gattcatcaa ctgcaagtga gagtaaatgg ctgggagcaa gtgagcccag     9120

tgtctgtgga caaagtcggg accttttttc gatatgcagc accagataaa aattcatctt     9180

cctctacgat tggcagccca agcagcagaa caaatattat acatccccag gtttatttct     9240

cttcactccc accagtgcgg gtggtctttg cagtgactat ggaaggcagt gcacggaaag     9300

tcatcactgt ccggtcagcc ctcattgtga ggaacagact tgagacacca atggaactaa     9360

gactggatag cccatcagct ccagacaagc cagtggtgct tcctgctatc atgccagggg     9420

attcgtttgc tgtgccttta cacctcactt cttggcggct acaggcccgg cccaaaggat     9480

tgggtgtatt tttctgtaag gctcccattc attggaccaa tgtagtgaag actgcagaaa     9540

ttagtagcag taaacgagag tgccactcta tggacacaga aaaaagccga tttttcaggt     9600

tttgtgtggc tataaagaaa gagaattatc cagattatat gccctcaaac atattttctg     9660

acagtgcaaa acagattttc agacagcctg ggcataccat atatctcctg ccaactgtgg     9720

taatctgcaa cttgctaccc tgtgaacttg atttttatgt taaaggaatg ccaattaatg     9780

ggacgctgaa acctggcaag gaggcagctc tccatacagc tgatacatcc cagaacattg     9840

agctgggggt atcactggag aatttccccc tctgtaaaga attgctcatt ccacctggaa     9900

cccaaaacta tatggtgaga atgcgactct atgacgtcaa ccgtcggcag ctgaacctca     9960

ccatccggat tgtgtgtcga gcagaaggat ccttaaagat cttcatttct gctccatatt    10020

ggctgattaa caaaacaggg ttgccactga tcttcagaca ggacaatgcc aagacagatg    10080

ctgcaggcca gtttgaggag catgagctgg cccgtagcct gagtcctctc ttattctgct    10140

atgctgacaa agagcagcca aacctctgca cgatgagaat cggaaggggg attcatccag    10200

aaggcatgcc gggctggtgt cagggcttct ccctggatgg tggtagtggt gtccgagctt    10260

tgaaagtcat ccagcaagga aaccgcccag ggctgatcta taacattggt attgatgtca    10320

agaaaggccg aggtcgatac attgatacct gcatggtcat ctttgccccc cgttacctgt    10380

tagataataa atcatctcac aagcttgcat ttgcacagag ggaatttgcc aggggacagg    10440

gaacagccaa tcccgaaggt tacatttcca cccttcctgg ttccagtgtg gtgttccact    10500

ggcctcggaa tgactatgat cagctattgt gtgtcagact gatggacgtt cccaattgta    10560

tttggtctgg aggctttgaa gtcaacaaga ataattcctt ccatatcaac atgagggata    10620

ccttgggaaa atgcttcttc ctacgagtgg aaattactct ccgaggagct acgtatagga    10680

tctcatttag tgacacagat cagttacctc ctcctttccg aattgacaac ttttctaagg    10740

tcccggttgt ctttactcag catggcgtag ctgaacccag gctccggact gaagtgaagc    10800

ccatgacttc attggattat gcctgggacg aacccacctt gccacctttt atcactctga    10860

ctgttaaagg ggcagggtcc tctgagatca actgcaacat gaatgatttc caggataatc    10920

ggcagcttta ttatgaaaat ttcatttaca ttgctgctac atatacattc tctggcttgc    10980

aggagggaac aggcaggcct gtggcttcca acaaggccat tacctgtgcg gagctcgttt    11040

tggatgtctc acccaagaca caaagagtca ttttaaaaaa gaaggaacca ggaaagcgtt    11100

ctcagctgtg gaggatgaca ggaacaggaa tgctggccca tgagggctcc tcagttcctc    11160

acaatcccaa taagccctca gccgcccgct ccaccgaggg gtctgccatc ttagatattg    11220

ctggtctcgc tgcagtgact gacaacagat acgagccact gatgctgaga aagcctgacc    11280

gcaggcgaag cacaactcag acgtggagtt tccgagaagg aaaactgacc tgtgggttac    11340

atgggttggt cgtccaggcc aaaggaggac tttctggttt gtttgatgga gctgaagttg    11400

ttcttggtcc tgacacttcc atggagcttt tggggccagt tccacctgaa caacaattta    11460

ttaatcaaaa aatgagacct ggttctggaa tgttatccat cagagtcatc ccagatggac    11520

caactagagc actccagata acagatttct gccaccggaa aagcagccgt tcatatgaag    11580

tggatgaact tcctgtcacc gaacaagagc tgcagaaatt aaagaatcca gatacagagc    11640

aggaattgga agtgcttgtg aggttagaag gtggaattgg gttgtcctta attaataaag    11700

tcccagaaga actggtcttt gcaagtctta caggaatcaa tgtgcactat acacagctgg    11760

caaccagtca catgcttgaa ctcagcatac aggatgtaca ggtggacaat cagctcattg    11820

gtaccacgca gcccttcatg ctctatgtga ctcccctgag caatgagaat gaggtcatcg    11880

agaccggccc agctgtgcaa gtcaacgcag tgaagttccc cagtaagagt gcactgacca    11940

acatctacaa gcatctgatg atcacagctc agagattcac agtgcaaatt gaggagaaac    12000

tgctcctcaa gctgctaagt ttctttggct acgatcaagc agaatcagag gtggaaaaat    12060

atgatgaaaa cctccatgaa aagacagctg agcaaggtgg aacaccaatt cgatactact    12120

ttgaaaatct caaaatcagc attcctcaga tcaagctaag tgtgttcacc tccaacaagc    12180

tcccattgga tcttaaggcc ctaaaaagca ccttggggtt tcctttgata cggtttgaag    12240

acgctgtgat taatctagat ccattcactc gggtacatcc ctatgagacc aaggagttca    12300

tcatcaatga tatcctcaaa catttccagg aggaactcct cagccaggca gctcgaatcc    12360

tgggatcagt ggattttctt ggcaatccta tggggctttt gaatgatgtt tctgaagggg    12420

ttactggact gataaaatat ggaaatgtcg ggggcctcat cagaaatgtt acacacggag    12480

tatcaaactc tgctgccaag tttgctggaa cattatcaga tggcttaggg aagacgatgg    12540

acaatcggca tcagtcagag cgggagtaca tcaggtacca tgcagccaca agtggtgaac    12600

accttgtagc cggcatccat ggcctggctc atggtatcat tggtggactg accagtgtta    12660

taacttcgac agtggaaggt gtgaaaacag aagggggtgt cagcggtttc atatctggcc    12720

ttggaaaagg gcttgttggc actgtaacca agccagtggc aggcgccctg gattttgcat    12780

cagaaacagc ccaggcggtg agagacacag ccacactcag cggccccagg actcaagcac    12840

agagggttcg gaaaccgcgt tgctgcacgg ggccccaggg gctgcttccc cgatattctg    12900

agagccaggc ggaaggacag gagcagctct tcaaactcac agacaacata caggacgaat    12960

tcttcatcgc tgtggagaac attgacagct actgcgtgct catctcctcc aaagctgttt    13020

acttcctgaa aagtggagac tacgtggatc gagaagccat tttcctagaa gtcaaatacg    13080

atgacctcta ccactgcctt gtctccaaag accatgggaa ggtgtatgtg caggtgacca    13140

agaaagccgt gagcacgagc agtggagtgt ccatccccgg cccctcccac cagaagccca    13200

tggtccatgt gaaatctgag gtccttgctg tcaagttgtc acaagaaata aactacgcaa    13260

agagcctcta ctatgaacag cagcttatgt taagactcag cgaaaaccga gagcagctgg    13320

agctggactc ctgaagcccc gctgctgaga tgggcgctcc cgacacagcg cagacccacc    13380

aggaggaaag aggcccagct ctcagctgac gatggaggca gaaccggagt cgggtttggg    13440

gaagttgtca aggaatgagg gaaagtaaat cctcatgagg aaaagtacaa atggaaatcg    13500

tattaatttg tgaggcaggg agttatttta gattatggga aataattttt aaaggtattg    13560

gttaaataac gtttaaaaac atgtactgag atgaatctaa tttttagatt gccctgtatt    13620

ttgttaacat gtatatatgt acaacagtgt gtttgtaaat atataggaac gtttctgaac    13680

agggtctgtg ctatgtgtaa aggtttgtta actgtaaagt aatataaagt tatattggat    13740

cttctattgc actaattcta gatgtctaat tcaggatact gtctatagaa aggcattctt    13800

aaaagttaaa gaatgttacg tcttagtttt ggagactaaa gtattcccag taaagtgggt    13860

tgaggtgagg gctgtggtcc tgaaagggac gcctttgaca tcgtggctgt ccagttgggc    13920

tgtgagctgt ggcacccagg actggcgctg gcccttcaga aggatctagg agaggggctt    13980

gggagcccac ttttaatttc tcacccccat tttacaaaga gtgcttagat tcttacaaat    14040

tatgatgtaa gttatccatt tggctttttc ctaactagtc ttaccaaact tagggggaaa    14100

cctgtgctcc attaccacat gggtgcaagt cagcattgta agttttctca ggttattatt    14160

attagagagg ttggaaacat tggtaaactc tgttgattga gaaggaaaaa aaaagtccca    14220

ttgaactgtt gcaacaaatc agaaatccac ataaaagtgc tctcctgcct gggcagcaac    14280

aaccaagaac aaagccccgg gactgttttc tttttaataa agccacaggc aggcatcgta    14340

gctccacagc ccgaggggac acaggatgga aaccccagga tgagaaggga gcagggagag    14400

ttccagaaag ggggatgaaa taggagtatt aaaaagctgc gttggtaagt ttttcatgga    14460

accaagattt gacaaaggca tctcttatcc ttggttttaa attcctgctg ggagcaaggc    14520

ctggtatgag cgccctgggt cttgtttttg gtgtttcgct tttctgtaag gattaagcag    14580

atagggagaa gggaaaaggg gcctcacttt agaatgaatg agtcaccttg tgatttttaa    14640

atttttattt taataaagct aatcaatttc tacaaccttg tcacatgtag ctgagtctgg    14700

gatgactcag tggatcagtg gatgcgtgga aggttttggt gtttataact catgacccaa    14760

atccttccaa gacacaaatg aagctaatct tcttcccctc cctttcctct cccacttccc    14820

ctctgtgtct gtgtctgtgt gtgtgtgtgt gtgtgtgtgt gtgtgcgcgc gcgcgcgtgc    14880

atgcagagag gaaggaaggg agctttagca caagtagcta catagtgttc aaggatcagc    14940

tttcttgaac tccgaggctt ggttgccttt gctgaactcc aagttagtgg attgcagaat    15000

ggaaacttgg cttttgcggc actgggtgag ttttagtttg tgtgtgtctt gctggggggt    15060

ggtgatgatt gtctcagcac tcacgcactg cacaagatgg cagcaggata cagcactgca    15120

caagatggca gctcctctgc agcttcctcc tcagcctccc tccttgcacc cccacaggtt    15180

tggcttgtgg tttttgtcat cagtaaccta ctgcctgaga tcatgatctc ttaaaagatg    15240

agactctcgg aagggttgat tgtatgcgtc agtgagcctt ctatcacctt ctggaacaaa    15300

gtcacttgaa atctcttgat gagattaagg agtttagtgt tactaagaaa atctgctttg    15360

ggccgcagca gtgctgggtg ttctcagacc tgactgagga agttagctgc gggctgccct    15420

gtgggctggt gcttcaggag gaatccagag aagtgttcag atgcccccct tgggctcctt    15480

tctaatttta atcagctctt taaatagctg cccatctcct gtgattgcac aaccaagcac    15540

tttgacattt gcaccttagg agaggcagat gttaaaatgg aatccaaaga ccacctaggg    15600

cggggctggg tgggagatgg gagggccaac tgcgagctgc tccacttctc agctctcccc    15660

tgccctgcag ccctgggcca gacaaggcca gaaggtttca ggggcatttg acatcccctc    15720

ctggttctca ccaggaaaac atccaaagct ttggaggaaa caggccctgc ccctggctcc    15780

ttaaatgccc cgtctctttg taaactgata ttcagccagc aatgcctaag actttgttaa    15840

gatcatttct actgcttttc tttctgcttc aaacacacag ttcgtctctg aggaaagtaa    15900

aataaatgga ataagagtaa attgggtaag gagatatcca aagctaccca gtcccttgac    15960

ccagcacagt tggccgaccc gtgtcactcc ctggctgtcg ctgcttctct gtgctcactg    16020

aagggtgagc caggccagtg cttccccagc ccctgggcct ggtcactaca cagtggaaaa    16080

cagacaagcg gccccttccc caaatcccaa gagtgtcttg ctgcttggtg ggtgctcatc    16140

gcaatgttct gaaggctcca gggccacttt gtttgtaagt atgatctggg cctcaaaata    16200

ccatagtagc tgcttgataa aattctaaaa atatctggtt ctctattatg taaacactat    16260

tacagtcacc agtgtgtgaa gactcttgag tctggttctc atatcagagt catcattttt    16320

cttcctgtgg aataaaatgc cttgtggact tcccaaa                             16357


<210>  2
<211>  16282
<212>  DNA
<213>  Homo Sapiens

<400>  2
ctgagcgccg cgggcctgcg ccattgagga gcggcgggga ggaaacgccg cgcagcgccg       60

ggctggggcg ggcggcccgg gacaccgaca gatttttctg tgaccatgaa agagagaaat      120

aaagaatgat ccatgatttc taaacacctt ttcctgagga tatagtcatg ttggaaggcc      180

ttgtagcctg ggttctcaat acctatttgg gaaaatatgt caataacctg aacactgacc      240

agctctcagt tgcacttctc aaaggtgctg ttgaattaga aaacttgcca ttaaagaaag      300

atgccttgaa agaattggaa ttaccatttg aagtcaaagc tggcttcatt gggaaagtaa      360

cccttcagat tcccttttat cgcccccatg tggacccttg ggtgatctcc atctccagcc      420

ttcacttaat tggagcccca gagaaaatac aggatttcaa tgatgaaaag gagaagctgt      480

tggaaaggga acgtaagaaa gcactacttc aagccctgga ggagaaatgg aagaatgacc      540

gccagcagaa aggggagtcc tattggtatt cagttaccgc ctccgtagtt acaaggattg      600

tggagaatat tgaattaaaa attcaagatg tccatttacg ctttgaagat ggtgtcacca      660

atccctccca tccttttgct tttggcatct gcattaagaa tgtgtccatg caaaatgctg      720

tgaatgagcc tgtacagaaa ctaatgcgga aaaagcaatt agacgtagca gaatttagca      780

tctattggga tgtcgattgc actttactgg gggatttgcc tcagatggag ttacaggagg      840

ccatggccag gagcatggag agtcgcagcc atcactacgt cctggagcct gtgtttgcat      900

ctgctctttt gaagagaaac tgctccaaga agcccctgcg gtctcggcac agtccccgta      960

ttgattgtga tattcagctg gagaccattc ccttgaaact ctctcagctg caataccggc     1020

aaatcatgga attcctcaag gagctggaac gaaaggagag gcaggtgaag ttccgaaggt     1080

ggaaacccaa ggtggcgata tctaagaact gccgagaatg gtggtatttt gctttgaatg     1140

ctaacttgta tgagatcaga gagcagagga aacgttgcac ctgggacttt atgttgcacc     1200

gcgctcgtga tgctgtatct tacactgaca aatatttcaa caagttaaaa ggaggcctgc     1260

tgtccacaga tgacaaggag gaaatgtgtc ggattgaaga ggaacagagc tttgaggaat     1320

tgaagatttt gcgtgaactg gttcatgatc gatttcacaa acaggaagaa ctagcagaga     1380

gtctgcggga gcctcagttt gattctccag gagcctgtcc gggagcccca gaacccggtg     1440

gaggcagtgg gatgctgcag tatctccagt cctggtttcc tggatggggt ggctggtacg     1500

ggcagcagac cccagaaggg aatgtggttg agggactgtc agcagagcaa caggagcagt     1560

ggattcctga agagatcctg ggcactgagg agttttttga ccccactgca gatgcctcgt     1620

gtatgaacac gtatacaaag cgagatcatg tctttgccaa actgaatttg cagttgcagc     1680

gaggtacagt gactctgtta cacaaggagc aaggaactcc tcaaatgaat gaaagtgctt     1740

tcatgcagct cgagttttca gatgtaaaac ttctagcaga gtctcttcct cgaagaaatt     1800

cctcgttgct ttcagtccgg ttgggtggac tgtttcttcg agacctggct acagaaggaa     1860

ctatgtttcc tcttctagtc ttccctaatc cacaaaaaga agttggcaga gtctcacaat     1920

cttttggtct acaaactaca tctgcagaca gaagtgatca ttacccagct gcagatccag     1980

atggccccgt ttttgagatg ctgtatgaga gaaatccggc gcacagccac tttgagaggc     2040

ggctcaatgt cagcacaagg cccttgaaca tcatatacaa tccgcaggcc attaaaaaag     2100

tagcagactt tttctacaag ggaaaggttc atacctcagg ttttggttat cagtctgaac     2160

ttgagctgag agtggctgaa gctgcccgaa gacaatataa caagctgaag atgcagacca     2220

aggcagaaat ccggcaaact cttgatcgtt tgctagtggg tgatttcatt gaggagagta     2280

aacgatggac cgtgcggctg gatatttctg cccctcaggt gatatttcct gatgatttca     2340

aattcaagaa tcctgtgtta gttgtcgtgg atctaggaag aatgcttttg acgaacaccc     2400

aagataactc caggaggaaa agtagggatg ggtcagcatc tgaagagacc cagtttagtg     2460

atgatgaata taagaccccc ctggccacac ctcctaacac cccacctccc gagtcaagca     2520

gcagcaacgg agagaaaaca cctccctttt ctggagttga gttcagtgaa gaacagcttc     2580

aagcacattt aatgagcaca aagatgtatg agaggtactc gctgtcattt atggacctcc     2640

agatcatggt tggacgagtg aaagacaatt ggaagcatgt ccaggatatt gacgtgggac     2700

caacacatgt ggtagagaag ttcaacgttc acctacagtt agagcgtcga ttgatttata     2760

cttcagatcc caaatatcca ggagccgtgc tctcaggcaa cttaccagac ttaaaaatcc     2820

acattaatga agataaaata tctgcactaa agaattgctt tgctctcctc accaccccag     2880

aaatgaaaac ttctgacact cagattaaag aaaagatttt tccccaggag gagcagcggg     2940

gaagtttgca agactccgta atgaatttaa cccagagcat tgtgttgttg gagcagcata     3000

cccgcgaggt tctggtggag tcgcagctcc tcctggcgga atttaaagtg aactgtatgc     3060

agcttggtgt tgagagcaat ggccggtaca tttctgtgct caaggtgttt ggtaccaatg     3120

ctcactttgt gaagaggcct tatgatgctg aagtctccct aactgttcat ggtttgctcc     3180

tggtggatac catgcagaca tatggtgctg attttgacct tttgatggct tcacataaga     3240

acttgagctt tgatattcca acgggaagcc ttcgggatag cagggcccag tctcctgtct     3300

ctggaccgaa tgtggcccac ttaactgatg gagctacact gaacgaccga tcagctacta     3360

gtgtttcact tgacaaaatt cttaccaaag agcaagagtc ccttattaag ttggaatatc     3420

agtttgtgag ttcagagtgc ccatcgatga atttagacag tactcttcag gtgatttccc     3480

tacaggtgaa taatttagat attatcctca atccagagac gattgtggag ctaattggtt     3540

ttcttcaaaa atcctttccc aaggaaaaag atgatttaag tcctcaacct ttaatgactg     3600

attttgaaag aagcttcaga gaacaaggaa cttaccagtc tacatatgaa caaaacactg     3660

aggttgcagt ggaaatccat aggctgaact tactgcttct tcggacagtg ggcatggcaa     3720

atagagagaa atatggcaga aaaattgcaa ctgcaagtat aggtggcacc aaagttaatg     3780

tctcaatggg tagcacgttt gacatgaatg gttctcttgg ctgtttacag cttatggatt     3840

tgacacaaga taacgttaaa aaccagtatg ttgtcagcat tgggaattct gtaggctatg     3900

aaaatatcat cagtgatatt ggctactttg aatctgtgtt tgtcagaatg gaagatgcag     3960

ccctcactga agctttgagt ttcacgtttg ttgagagatc taaacaggag tgttttctca     4020

acctgaagat ggcttcttta cattataacc actctgctaa gtttttgaag gagttgacgt     4080

tatccatgga tgaactggaa gaaaattttc gaggtatgct gaaaagcgca gccaccaaag     4140

tcaccacagt actagctacc aagactgccg agtatagcga gatggtatcg ctctttgaaa     4200

ctccaaggaa gactcgggaa ccctttatct tagaggaaaa tgaaatatat gggtttgacc     4260

tagcttcgtc tcatttggac actgtaaagc taatcttgaa cataaacatt gaatcaccag     4320

ttgtttctat ccctcggaag ccggggagtc ctgagttgtt ggtgggacac ttgggacaga     4380

tattcatcca gaattttgtg gcgggagatg atgaatccag aagtgaccgt ctgcaggtgg     4440

aaatcaagga cattaaactg tattctttga attgcaccca gttggcaggt agagaagctg     4500

ttgggtctga aggaagccgg atgttttgcc caccttccgg gtctggcagt gccaacagtc     4560

aggaggaagc tcatttcaca cgacatgatt tctttgaatc tttgcataga ggtcaagctt     4620

ttcacatcct gaacaacacc accattcagt ttaaactgga gaagatccct atagagagag     4680

aatctgaatt gactttttct cttagcccag atgacctggg aacttctagc atcatgaaga     4740

ttgaaggaaa atttgtcaat ccagttcagg tggtgttagc aaagcatgta tatgagcagg     4800

ttttacaaac cctggacaat ctcgtgtaca gtgaagatct gaataagtat ccagccagtg     4860

ctacctcctc cccttgccct gattctcctc tgcctcccct cagtacctgt ggagaatctt     4920

ctgttgaaag gaaggagaat ggattgttca gccactccag cctttctaac acctctcaga     4980

agtcattgtc agtgaaggaa gtcaaatcct ttactcagat tcaagccacc ttttgtatat     5040

cagagcttca ggttcagcta agtggagatc tgactttggg ggcccaaggt cttgtgagct     5100

taaagtttca ggactttgag gtggaattca gtaaagacca tccccagact ttatctattc     5160

agattgccct gcattctctg ctgatggagg acttattgga gaagaatcca gattctaaat     5220

ataagaacct gatggtgtct cgaggagccc ctaagccatc tagtttagca caaaaagaat     5280

acctttctca gtcttgcccc tcagtgtcca atgtggaata tcctgatatg cctcggtctc     5340

tcccttccca catggaagaa gctcctaatg tcttccagtt gtatcaaagg cccacctctg     5400

cgtcccggaa aaagcaaaag gaagtccaag acaaggacta tcccttgacc ccacctcctt     5460

ctccaacagt ggatgagccc aagatacttg ttggaaagag taaatttgat gattccttag     5520

tccacatcaa catattcttg gtagataaga aacatccaga attctcttcc agttacaatc     5580

gagttaaccg gagcattgat gttgatttta attgcttgga tgtgctgatc acactgcaaa     5640

cctgggttgt gatattagac ttttttggaa tcggctccac tgcagacaac cacgcaatga     5700

ggctgcctcc tgagggcatt ctgcacaacg tgaagttgga gccacatgcc tccatggagt     5760

ctggacttca ggatccagtg aacaccaaac tggatctcaa ggttcattca ctttctctag     5820

tgctgaataa gaccaccagt gagcttgcca aagcaaatgt gtccaaatta gtagcacacc     5880

tggaaatgat tgagggagac ctggccttac agggcagcat tgggagtctg tctctaagtg     5940

acctcacatg ccatggagag ttctacagag aacggttcac taccagtggt gaagaagcac     6000

tcatcttcca gacttttaaa tacggacggc ctgaccctct gctccggaga gaacacgaca     6060

ttcgcgtgag cctccggatg gcctctgtgc agtatgtgca tactcagcgt ttccaggcag     6120

aggtggtggc cttcattcag catttcactc agctgcagga tgtcttaggg cgccagcgag     6180

ctgctattga ggggcagacg gtgagagatc aagcccagcg ctgttcacgg gttctcctgg     6240

atattgaggc tggtgctccc gttctcttga tcccagaaag ttccagatca aataatctga     6300

ttgtagcaaa tttggggaag ttgaaagtca aaaataagtt tctgtttgct ggttttcctg     6360

gcaccttttc cctacaagat aaggaatctg tgccttcagc ttccccaacg ggtattccca     6420

aacacagtct gaggaaaacg acaagcacgg aggagcccag gggaacccat tcccaggggc     6480

agttcacgat gcctcttgct ggaatgagcc taggaagcct gaagagtgag tttgtgccca     6540

gtacctccac caagcagcaa gggccgcaac ccacactgtc tgttggccaa gagtccagta     6600

gtccagaaga ccatgtctgc ctgctggatt gcgttgtcgt ggatctccag gacatggaca     6660

tctttgctgc agagagacat ccgagagaat actcgaaggc accagaggat agtagtggag     6720

atctgatctt cccttcctat tttgtgcgac agacaggagg aagcctctta accgagcctt     6780

gtaggctgaa attgcaggtg gaaaggaatt tggacaaaga aataagtcat actgtgccag     6840

acatatctat ccatggcaat ctctcctcag tccactgctc tctggatctg tataaataca     6900

agctgatccg cggcttatta gagaacaacc tgggagaacc catagaggaa tttatgcggc     6960

cttatgattt acaagatcca agaattcata ctgtcctgag tggagaagtg tacacctgta     7020

tgtgcttcct cattgatatg gtgaatgtaa gtctggagct taaagatcca aaaagaaaag     7080

aaggtgctgg gtccctagcc agatttgact tcaagaaatg caaactgctc tatgaaagtt     7140

tttccaacca aaccaagtcc attaacttgg tttcccattc catgatggct tttgacaccc     7200

gttatgctgg gcagaagacc agccctggca tgacgaatgt gttcagctgt atctttcagc     7260

ccgctaagaa cagcagcacc acccaagggt ccattcagat tgaactacat ttcagatcta     7320

ccaaggattc ctcctgcttt acagtagttc tcaacaatct ccgtgtgttt ctcatatttg     7380

actggctact gttagtccat gattttctcc acactcccag tgatattaag aaacaaaatc     7440

atgttactcc ttctcgccac cgtaactcta gcagcgaatc tgctatagtt cccaaaactg     7500

tgaagagtgg agtagttacc aagcggtctt cccttcctgt gtccaatgaa aggcacctgg     7560

aggtcaaggt caatgtaaca ggtacggagt ttgtggtcat tgaagatgtg tcctgcttcg     7620

acaccaatgc cattattctg aaaggcacca cagtgctcac ctataagccc cggtttgttg     7680

atcgcccctt ttcaggaagt ttgtttggca ttgaggtgtt ttcatgccga ctagggaatg     7740

agcatgatac agctctttca attgtggatc ccgtacaaat tcaaatggag ttggtgggga     7800

attcttctta tcaaaatagt tcaggattga tggatgcatt caatagtgaa gatttcccac     7860

ctgtcctgga gattcagtta caagccctgg atatcagact ctcctataat gatgttcagc     7920

tgtttcttgc cattgcaaaa tccatcccag agcaagctaa tgctgcagtg ccagactcag     7980

tggccctgga gtcagactcc gttggcactt accttccagg tgcatctcgc gttggagagg     8040

aaatcagaga agggacaaga cacaccttag atcctgtctt ggagttacag ctggctaggc     8100

tgcaggagct gggattcagc atggatgatt gtcgcaaagc tcttttggcg tgtcaaggcc     8160

aattgaaaaa ggcagcaagt tggttgttta agaatgcgga acctctgaag tctctttcct     8220

tggcctccac cagccgagat agcccagggg ctgtggcagc gccattgatc tctggcgtgg     8280

agatcaaagc tgagagtgtg tgcatctgtt tcatcgatga ctgcatggat tgtgatgttc     8340

ctctcgctga actcaccttt tcccgtctga attttcttca gcgtgtaaga actagccctg     8400

aaggctatgc ccacttcacc ctttctggag attattataa ccgtgctctt tcaggctggg     8460

agccatttat tgagccttgg ccatgctctg tatcctggca acagcaggca gctagtcgtc     8520

tccatcctcc tcgactgaag ctagaagcca aggccaaacc tcgtttggat atcaatatca     8580

cttctgtgct aattgaccag tatgtaagta ccaaggaatc gtggatggca gattactgta     8640

aagatgacaa ggacatagag tcagctaaat cagaagactg gatgggctct tcggtggatc     8700

ctccatgttt tggacaaaca gaggtgaaaa cccccaagcg ccggcagcca tttgtcccct     8760

ttgctctgag gaaccacacg gggtgcactt tgtggtttgc caccctgacc accacaccca     8820

ccagagctgc actctctcac agtgggagtc caggggtagt tccagaaggg aacggaacat     8880

ttctcgatga tactcacaat gttagtgaat ggcgagaagt ccttacaggt gaagagattc     8940

cctttgaatt tgaagcaaga ggaaagttaa gacacagaca cacccatgac ctccggattc     9000

atcaactgca agtgagagta aatggctggg agcaagtgag cccagtgtct gtggacaaag     9060

tcgggacctt ttttcgatat gcagcaccag ataaaaattc atcttcctct acgattggca     9120

gcccaagcag cagaacaaat attatacatc cccaggttta tttctcttca ctcccaccag     9180

tgcgggtggt ctttgcagtg actatggaag gcagtgcacg gaaagtcatc actgtccggt     9240

cagccctcat tgtgaggaac agacttgaga caccaatgga actaagactg gatagcccat     9300

cagctccaga caagccagtg gtgcttcctg ctatcatgcc aggggattcg tttgctgtgc     9360

ctttacacct cacttcttgg cggctacagg cccggcccaa aggattgggt gtatttttct     9420

gtaaggctcc cattcattgg accaatgtag tgaagactgc agaaattagt agcagtaaac     9480

gagagtgcca ctctatggac acagaaaaaa gccgattttt caggttttgt gtggctataa     9540

agaaagagaa ttatccagat tatatgccct caaacatatt ttctgacagt gcaaaacaga     9600

ttttcagaca gcctgggcat accatatatc tcctgccaac tgtggtaatc tgcaacttgc     9660

taccctgtga acttgatttt tatgttaaag gaatgccaat taatgggacg ctgaaacctg     9720

gcaaggaggc agctctccat acagctgata catcccagaa cattgagctg ggggtatcac     9780

tggagaattt ccccctctgt aaagaattgc tcattccacc tggaacccaa aactatatgg     9840

tgagaatgcg actctatgac gtcaaccgtc ggcagctgaa cctcaccatc cggattgtgt     9900

gtcgagcaga aggatcctta aagatcttca tttctgctcc atattggctg attaacaaaa     9960

cagggttgcc actgatcttc agacaggaca atgccaagac agatgctgca ggccagtttg    10020

aggagcatga gctggcccgt agcctgagtc ctctcttatt ctgctatgct gacaaagagc    10080

agccaaacct ctgcacgatg agaatcggaa gggggattca tccagaaggc atgccgggct    10140

ggtgtcaggg cttctccctg gatggtggta gtggtgtccg agctttgaaa gtcatccagc    10200

aaggaaaccg cccagggctg atctataaca ttggtattga tgtcaagaaa ggccgaggtc    10260

gatacattga tacctgcatg gtcatctttg ccccccgtta cctgttagat aataaatcat    10320

ctcacaagct tgcatttgca cagagggaat ttgccagggg acagggaaca gccaatcccg    10380

aaggttacat ttccaccctt cctggttcca gtgtggtgtt ccactggcct cggaatgact    10440

atgatcagct attgtgtgtc agactgatgg acgttcccaa ttgtatttgg tctggaggct    10500

ttgaagtcaa caagaataat tccttccata tcaacatgag ggataccttg ggaaaatgct    10560

tcttcctacg agtggaaatt actctccgag gagctacgta taggatctca tttagtgaca    10620

cagatcagtt acctcctcct ttccgaattg acaacttttc taaggtcccg gttgtcttta    10680

ctcagcatgg cgtagctgaa cccaggctcc ggactgaagt gaagcccatg acttcattgg    10740

attatgcctg ggacgaaccc accttgccac cttttatcac tctgactgtt aaaggggcag    10800

ggtcctctga gatcaactgc aacatgaatg atttccagga taatcggcag ctttattatg    10860

aaaatttcat ttacattgct gctacatata cattctctgg cttgcaggag ggaacaggca    10920

ggcctgtggc ttccaacaag gccattacct gtgcggagct cgttttggat gtctcaccca    10980

agacacaaag agtcatttta aaaaagaagg aaccaggaaa gcgttctcag ctgtggagga    11040

tgacaggaac aggaatgctg gcccatgagg gctcctcagt tcctcacaat cccaataagc    11100

cctcagccgc ccgctccacc gaggggtctg ccatcttaga tattgctggt ctcgctgcag    11160

tgactgacaa cagatacgag ccactgatgc tgagaaagcc tgaccgcagg cgaagcacaa    11220

ctcagacgtg gagtttccga gaaggaaaac tgacctgtgg gttacatggg ttggtcgtcc    11280

aggccaaagg aggactttct ggtttgtttg atggagctga agttgttctt ggtcctgaca    11340

cttccatgga gcttttgggg ccagttccac ctgaacaaca atttattaat caaaaaatga    11400

gacctggttc tggaatgtta tccatcagag tcatcccaga tggaccaact agagcactcc    11460

agataacaga tttctgccac cggaaaagca gccgttcata tgaagtggat gaacttcctg    11520

tcaccgaaca agagctgcag aaattaaaga atccagatac agagcaggaa ttggaagtgc    11580

ttgtgaggtt agaaggtgga attgggttgt ccttaattaa taaagtccca gaagaactgg    11640

tctttgcaag tcttacagga atcaatgtgc actatacaca gctggcaacc agtcacatgc    11700

ttgaactcag catacaggat gtacaggtgg acaatcagct cattggtacc acgcagccct    11760

tcatgctcta tgtgactccc ctgagcaatg agaatgaggt catcgagacc ggcccagctg    11820

tgcaagtcaa cgcagtgaag ttccccagta agagtgcact gaccaacatc tacaagcatc    11880

tgatgatcac agctcagaga ttcacagtgc aaattgagga gaaactgctc ctcaagctgc    11940

taagtttctt tggctacgat caagcagaat cagaggtgga aaaatatgat gaaaacctcc    12000

atgaaaagac agctgagcaa ggtggaacac caattcgata ctactttgaa aatctcaaaa    12060

tcagcattcc tcagatcaag ctaagtgtgt tcacctccaa caagctccca ttggatctta    12120

aggccctaaa aagcaccttg gggtttcctt tgatacggtt tgaagacgct gtgattaatc    12180

tagatccatt cactcgggta catccctatg agaccaagga gttcatcatc aatgatatcc    12240

tcaaacattt ccaggaggaa ctcctcagcc aggcagctcg aatcctggga tcagtggatt    12300

ttcttggcaa tcctatgggg cttttgaatg atgtttctga aggggttact ggactgataa    12360

aatatggaaa tgtcgggggc ctcatcagaa atgttacaca cggagtatca aactctgctg    12420

ccaagtttgc tggaacatta tcagatggct tagggaagac gatggacaat cggcatcagt    12480

cagagcggga gtacatcagg taccatgcag ccacaagtgg tgaacacctt gtagccggca    12540

tccatggcct ggctcatggt atcattggtg gactgaccag tgttataact tcgacagtgg    12600

aaggtgtgaa aacagaaggg ggtgtcagcg gtttcatatc tggccttgga aaagggcttg    12660

ttggcactgt aaccaagcca gtggcaggcg ccctggattt tgcatcagaa acagcccagg    12720

cggtgagaga cacagccaca ctcagcggcc ccaggactca agcacagagg gttcggaaac    12780

cgcgttgctg cacggggccc caggggctgc ttccccgata ttctgagagc caggcggaag    12840

gacaggagca gctcttcaaa ctcacagaca acatacagga cgaattcttc atcgctgtgg    12900

agaacattga cagctactgc gtgctcatct cctccaaagc tgtttacttc ctgaaaagtg    12960

gagactacgt ggatcgagaa gccattttcc tagaagtcaa atacgatgac ctctaccact    13020

gccttgtctc caaagaccat gggaaggtgt atgtgcaggt gaccaagaaa gccgtgagca    13080

cgagcagtgg agtgtccatc cccggcccct cccaccagaa gcccatggtc catgtgaaat    13140

ctgaggtcct tgctgtcaag ttgtcacaag aaataaacta cgcaaagagc ctctactatg    13200

aacagcagct tatgttaaga ctcagcgaaa accgagagca gctggagctg gactcctgaa    13260

gccccgctgc tgagatgggc gctcccgaca cagcgcagac ccaccaggag gaaagaggcc    13320

cagctctcag ctgacgatgg aggcagaacc ggagtcgggt ttggggaagt tgtcaaggaa    13380

tgagggaaag taaatcctca tgaggaaaag tacaaatgga aatcgtatta atttgtgagg    13440

cagggagtta ttttagatta tgggaaataa tttttaaagg tattggttaa ataacgttta    13500

aaaacatgta ctgagatgaa tctaattttt agattgccct gtattttgtt aacatgtata    13560

tatgtacaac agtgtgtttg taaatatata ggaacgtttc tgaacagggt ctgtgctatg    13620

tgtaaaggtt tgttaactgt aaagtaatat aaagttatat tggatcttct attgcactaa    13680

ttctagatgt ctaattcagg atactgtcta tagaaaggca ttcttaaaag ttaaagaatg    13740

ttacgtctta gttttggaga ctaaagtatt cccagtaaag tgggttgagg tgagggctgt    13800

ggtcctgaaa gggacgcctt tgacatcgtg gctgtccagt tgggctgtga gctgtggcac    13860

ccaggactgg cgctggccct tcagaaggat ctaggagagg ggcttgggag cccactttta    13920

atttctcacc cccattttac aaagagtgct tagattctta caaattatga tgtaagttat    13980

ccatttggct ttttcctaac tagtcttacc aaacttaggg ggaaacctgt gctccattac    14040

cacatgggtg caagtcagca ttgtaagttt tctcaggtta ttattattag agaggttgga    14100

aacattggta aactctgttg attgagaagg aaaaaaaaag tcccattgaa ctgttgcaac    14160

aaatcagaaa tccacataaa agtgctctcc tgcctgggca gcaacaacca agaacaaagc    14220

cccgggactg ttttcttttt aataaagcca caggcaggca tcgtagctcc acagcccgag    14280

gggacacagg atggaaaccc caggatgaga agggagcagg gagagttcca gaaaggggga    14340

tgaaatagga gtattaaaaa gctgcgttgg taagtttttc atggaaccaa gatttgacaa    14400

aggcatctct tatccttggt tttaaattcc tgctgggagc aaggcctggt atgagcgccc    14460

tgggtcttgt ttttggtgtt tcgcttttct gtaaggatta agcagatagg gagaagggaa    14520

aaggggcctc actttagaat gaatgagtca ccttgtgatt tttaaatttt tattttaata    14580

aagctaatca atttctacaa ccttgtcaca tgtagctgag tctgggatga ctcagtggat    14640

cagtggatgc gtggaaggtt ttggtgttta taactcatga cccaaatcct tccaagacac    14700

aaatgaagct aatcttcttc ccctcccttt cctctcccac ttcccctctg tgtctgtgtc    14760

tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg cgcgcgcgcg cgtgcatgca gagaggaagg    14820

aagggagctt tagcacaagt agctacatag tgttcaagga tcagctttct tgaactccga    14880

ggcttggttg cctttgctga actccaagtt agtggattgc agaatggaaa cttggctttt    14940

gcggcactgg gtgagtttta gtttgtgtgt gtcttgctgg ggggtggtga tgattgtctc    15000

agcactcacg cactgcacaa gatggcagca ggatacagca ctgcacaaga tggcagctcc    15060

tctgcagctt cctcctcagc ctccctcctt gcacccccac aggtttggct tgtggttttt    15120

gtcatcagta acctactgcc tgagatcatg atctcttaaa agatgagact ctcggaaggg    15180

ttgattgtat gcgtcagtga gccttctatc accttctgga acaaagtcac ttgaaatctc    15240

ttgatgagat taaggagttt agtgttacta agaaaatctg ctttgggccg cagcagtgct    15300

gggtgttctc agacctgact gaggaagtta gctgcgggct gccctgtggg ctggtgcttc    15360

aggaggaatc cagagaagtg ttcagatgcc ccccttgggc tcctttctaa ttttaatcag    15420

ctctttaaat agctgcccat ctcctgtgat tgcacaacca agcactttga catttgcacc    15480

ttaggagagg cagatgttaa aatggaatcc aaagaccacc tagggcgggg ctgggtggga    15540

gatgggaggg ccaactgcga gctgctccac ttctcagctc tcccctgccc tgcagccctg    15600

ggccagacaa ggccagaagg tttcaggggc atttgacatc ccctcctggt tctcaccagg    15660

aaaacatcca aagctttgga ggaaacaggc cctgcccctg gctccttaaa tgccccgtct    15720

ctttgtaaac tgatattcag ccagcaatgc ctaagacttt gttaagatca tttctactgc    15780

ttttctttct gcttcaaaca cacagttcgt ctctgaggaa agtaaaataa atggaataag    15840

agtaaattgg gtaaggagat atccaaagct acccagtccc ttgacccagc acagttggcc    15900

gacccgtgtc actccctggc tgtcgctgct tctctgtgct cactgaaggg tgagccaggc    15960

cagtgcttcc ccagcccctg ggcctggtca ctacacagtg gaaaacagac aagcggcccc    16020

ttccccaaat cccaagagtg tcttgctgct tggtgggtgc tcatcgcaat gttctgaagg    16080

ctccagggcc actttgtttg taagtatgat ctgggcctca aaataccata gtagctgctt    16140

gataaaattc taaaaatatc tggttctcta ttatgtaaac actattacag tcaccagtgt    16200

gtgaagactc ttgagtctgg ttctcatatc agagtcatca tttttcttcc tgtggaataa    16260

aatgccttgt ggacttccca aa                                             16282


<210>  3
<211>  4388
<212>  PRT
<213>  Homo Sapiens

<400>  3

Met Leu Glu Gly Leu Val Ala Trp Val Leu Asn Thr Tyr Leu Gly Lys 
1               5                   10                  15      


Tyr Val Asn Asn Leu Asn Thr Asp Gln Leu Ser Val Ala Leu Leu Lys 
            20                  25                  30          


Gly Ala Val Glu Leu Glu Asn Leu Pro Leu Lys Lys Asp Ala Leu Lys 
        35                  40                  45              


Glu Leu Glu Leu Pro Phe Glu Val Lys Ala Gly Phe Ile Gly Lys Val 
    50                  55                  60                  


Thr Leu Gln Ile Pro Phe Tyr Arg Pro His Val Asp Pro Trp Val Ile 
65                  70                  75                  80  


Ser Ile Ser Ser Leu His Leu Ile Gly Ala Pro Glu Lys Ile Gln Asp 
                85                  90                  95      


Phe Asn Asp Glu Lys Glu Lys Leu Leu Glu Arg Glu Arg Lys Lys Ala 
            100                 105                 110         


Leu Leu Gln Ala Leu Glu Glu Lys Trp Lys Asn Asp Arg Gln Gln Lys 
        115                 120                 125             


Gly Glu Ser Tyr Trp Tyr Ser Val Thr Ala Ser Val Val Thr Arg Ile 
    130                 135                 140                 


Val Glu Asn Ile Glu Leu Lys Ile Gln Asp Val His Leu Arg Phe Glu 
145                 150                 155                 160 


Asp Gly Val Thr Asn Pro Ser His Pro Phe Ala Phe Gly Ile Cys Ile 
                165                 170                 175     


Lys Asn Val Ser Met Gln Asn Ala Val Asn Glu Pro Val Gln Lys Leu 
            180                 185                 190         


Met Arg Lys Lys Gln Leu Asp Val Ala Glu Phe Ser Ile Tyr Trp Asp 
        195                 200                 205             


Val Asp Cys Thr Leu Leu Gly Asp Leu Pro Gln Met Glu Leu Gln Glu 
    210                 215                 220                 


Ala Met Ala Arg Ser Met Glu Ser Arg Ser His His Tyr Val Leu Glu 
225                 230                 235                 240 


Pro Val Phe Ala Ser Ala Leu Leu Lys Arg Asn Cys Ser Lys Lys Pro 
                245                 250                 255     


Leu Arg Ser Arg His Ser Pro Arg Ile Asp Cys Asp Ile Gln Leu Glu 
            260                 265                 270         


Thr Ile Pro Leu Lys Leu Ser Gln Leu Gln Tyr Arg Gln Ile Met Glu 
        275                 280                 285             


Phe Leu Lys Glu Leu Glu Arg Lys Glu Arg Gln Val Lys Phe Arg Arg 
    290                 295                 300                 


Trp Lys Pro Lys Val Ala Ile Ser Lys Asn Cys Arg Glu Trp Trp Tyr 
305                 310                 315                 320 


Phe Ala Leu Asn Ala Asn Leu Tyr Glu Ile Arg Glu Gln Arg Lys Arg 
                325                 330                 335     


Cys Thr Trp Asp Phe Met Leu His Arg Ala Arg Asp Ala Val Ser Tyr 
            340                 345                 350         


Thr Asp Lys Tyr Phe Asn Lys Leu Lys Gly Gly Leu Leu Ser Thr Asp 
        355                 360                 365             


Asp Lys Glu Glu Met Cys Arg Ile Glu Glu Glu Gln Ser Phe Glu Glu 
    370                 375                 380                 


Leu Lys Ile Leu Arg Glu Leu Val His Asp Arg Phe His Lys Gln Glu 
385                 390                 395                 400 


Glu Leu Ala Glu Ser Leu Arg Glu Pro Gln Phe Asp Ser Pro Gly Ala 
                405                 410                 415     


Cys Pro Gly Ala Pro Glu Pro Gly Gly Gly Ser Gly Met Leu Gln Tyr 
            420                 425                 430         


Leu Gln Ser Trp Phe Pro Gly Trp Gly Gly Trp Tyr Gly Gln Gln Thr 
        435                 440                 445             


Pro Glu Gly Asn Val Val Glu Gly Leu Ser Ala Glu Gln Gln Glu Gln 
    450                 455                 460                 


Trp Ile Pro Glu Glu Ile Leu Gly Thr Glu Glu Phe Phe Asp Pro Thr 
465                 470                 475                 480 


Ala Asp Ala Ser Cys Met Asn Thr Tyr Thr Lys Arg Asp His Val Phe 
                485                 490                 495     


Ala Lys Leu Asn Leu Gln Leu Gln Arg Gly Thr Val Thr Leu Leu His 
            500                 505                 510         


Lys Glu Gln Gly Thr Pro Gln Met Asn Glu Ser Ala Phe Met Gln Leu 
        515                 520                 525             


Glu Phe Ser Asp Val Lys Leu Leu Ala Glu Ser Leu Pro Arg Arg Asn 
    530                 535                 540                 


Ser Ser Leu Leu Ser Val Arg Leu Gly Gly Leu Phe Leu Arg Asp Leu 
545                 550                 555                 560 


Ala Thr Glu Gly Thr Met Phe Pro Leu Leu Val Phe Pro Asn Pro Gln 
                565                 570                 575     


Lys Glu Val Gly Arg Val Ser Gln Ser Phe Gly Leu Gln Thr Thr Ser 
            580                 585                 590         


Ala Asp Arg Ser Asp His Tyr Pro Ala Ala Asp Pro Asp Gly Pro Val 
        595                 600                 605             


Phe Glu Met Leu Tyr Glu Arg Asn Pro Ala His Ser His Phe Glu Arg 
    610                 615                 620                 


Arg Leu Asn Val Ser Thr Arg Pro Leu Asn Ile Ile Tyr Asn Pro Gln 
625                 630                 635                 640 


Ala Ile Lys Lys Val Ala Asp Phe Phe Tyr Lys Gly Lys Val His Thr 
                645                 650                 655     


Ser Gly Phe Gly Tyr Gln Ser Glu Leu Glu Leu Arg Val Ala Glu Ala 
            660                 665                 670         


Ala Arg Arg Gln Tyr Asn Lys Leu Lys Met Gln Thr Lys Ala Glu Ile 
        675                 680                 685             


Arg Gln Thr Leu Asp Arg Leu Leu Val Gly Asp Phe Ile Glu Glu Ser 
    690                 695                 700                 


Lys Arg Trp Thr Val Arg Leu Asp Ile Ser Ala Pro Gln Val Ile Phe 
705                 710                 715                 720 


Pro Asp Asp Phe Lys Phe Lys Asn Pro Val Leu Val Val Val Asp Leu 
                725                 730                 735     


Gly Arg Met Leu Leu Thr Asn Thr Gln Asp Asn Ser Arg Arg Lys Ser 
            740                 745                 750         


Arg Asp Gly Ser Ala Ser Glu Glu Thr Gln Phe Ser Asp Asp Glu Tyr 
        755                 760                 765             


Lys Thr Pro Leu Ala Thr Pro Pro Asn Thr Pro Pro Pro Glu Ser Ser 
    770                 775                 780                 


Ser Ser Asn Gly Glu Lys Thr Pro Pro Phe Ser Gly Val Glu Phe Ser 
785                 790                 795                 800 


Glu Glu Gln Leu Gln Ala His Leu Met Ser Thr Lys Met Tyr Glu Arg 
                805                 810                 815     


Tyr Ser Leu Ser Phe Met Asp Leu Gln Ile Met Val Gly Arg Val Lys 
            820                 825                 830         


Asp Asn Trp Lys His Val Gln Asp Ile Asp Val Gly Pro Thr His Val 
        835                 840                 845             


Val Glu Lys Phe Asn Val His Leu Gln Leu Glu Arg Arg Leu Ile Tyr 
    850                 855                 860                 


Thr Ser Asp Pro Lys Tyr Pro Gly Ala Val Leu Ser Gly Asn Leu Pro 
865                 870                 875                 880 


Asp Leu Lys Ile His Ile Asn Glu Asp Lys Ile Ser Ala Leu Lys Asn 
                885                 890                 895     


Cys Phe Ala Leu Leu Thr Thr Pro Glu Met Lys Thr Ser Asp Thr Gln 
            900                 905                 910         


Ile Lys Glu Lys Ile Phe Pro Gln Glu Glu Gln Arg Gly Ser Leu Gln 
        915                 920                 925             


Asp Ser Val Met Asn Leu Thr Gln Ser Ile Val Leu Leu Glu Gln His 
    930                 935                 940                 


Thr Arg Glu Val Leu Val Glu Ser Gln Leu Leu Leu Ala Glu Phe Lys 
945                 950                 955                 960 


Val Asn Cys Met Gln Leu Gly Val Glu Ser Asn Gly Arg Tyr Ile Ser 
                965                 970                 975     


Val Leu Lys Val Phe Gly Thr Asn Ala His Phe Val Lys Arg Pro Tyr 
            980                 985                 990         


Asp Ala Glu Val Ser Leu Thr Val  His Gly Leu Leu Leu  Val Asp Thr 
        995                 1000                 1005             


Met Gln  Thr Tyr Gly Ala Asp  Phe Asp Leu Leu Met  Ala Ser His 
    1010                 1015                 1020             


Lys Asn  Leu Ser Phe Asp Ile  Pro Thr Gly Ser Leu  Arg Asp Ser 
    1025                 1030                 1035             


Arg Ala  Gln Ser Pro Val Ser  Gly Pro Asn Val Ala  His Leu Thr 
    1040                 1045                 1050             


Asp Gly  Ala Thr Leu Asn Asp  Arg Ser Ala Thr Ser  Val Ser Leu 
    1055                 1060                 1065             


Asp Lys  Ile Leu Thr Lys Glu  Gln Glu Ser Leu Ile  Lys Leu Glu 
    1070                 1075                 1080             


Tyr Gln  Phe Val Ser Ser Glu  Cys Pro Ser Met Asn  Leu Asp Ser 
    1085                 1090                 1095             


Thr Leu  Gln Val Ile Ser Leu  Gln Val Asn Asn Leu  Asp Ile Ile 
    1100                 1105                 1110             


Leu Asn  Pro Glu Thr Ile Val  Glu Leu Ile Gly Phe  Leu Gln Lys 
    1115                 1120                 1125             


Ser Phe  Pro Lys Glu Lys Asp  Asp Leu Ser Pro Gln  Pro Leu Met 
    1130                 1135                 1140             


Thr Asp  Phe Glu Arg Ser Phe  Arg Glu Gln Gly Thr  Tyr Gln Ser 
    1145                 1150                 1155             


Thr Tyr  Glu Gln Asn Thr Glu  Val Ala Val Glu Ile  His Arg Leu 
    1160                 1165                 1170             


Asn Leu  Leu Leu Leu Arg Thr  Val Gly Met Ala Asn  Arg Glu Lys 
    1175                 1180                 1185             


Tyr Gly  Arg Lys Ile Ala Thr  Ala Ser Ile Gly Gly  Thr Lys Val 
    1190                 1195                 1200             


Asn Val  Ser Met Gly Ser Thr  Phe Asp Met Asn Gly  Ser Leu Gly 
    1205                 1210                 1215             


Cys Leu  Gln Leu Met Asp Leu  Thr Gln Asp Asn Val  Lys Asn Gln 
    1220                 1225                 1230             


Tyr Val  Val Ser Ile Gly Asn  Ser Val Gly Tyr Glu  Asn Ile Ile 
    1235                 1240                 1245             


Ser Asp  Ile Gly Tyr Phe Glu  Ser Val Phe Val Arg  Met Glu Asp 
    1250                 1255                 1260             


Ala Ala  Leu Thr Glu Ala Leu  Ser Phe Thr Phe Val  Glu Arg Ser 
    1265                 1270                 1275             


Lys Gln  Glu Cys Phe Leu Asn  Leu Lys Met Ala Ser  Leu His Tyr 
    1280                 1285                 1290             


Asn His  Ser Ala Lys Phe Leu  Lys Glu Leu Thr Leu  Ser Met Asp 
    1295                 1300                 1305             


Glu Leu  Glu Glu Asn Phe Arg  Gly Met Leu Lys Ser  Ala Ala Thr 
    1310                 1315                 1320             


Lys Val  Thr Thr Val Leu Ala  Thr Lys Thr Ala Glu  Tyr Ser Glu 
    1325                 1330                 1335             


Met Val  Ser Leu Phe Glu Thr  Pro Arg Lys Thr Arg  Glu Pro Phe 
    1340                 1345                 1350             


Ile Leu  Glu Glu Asn Glu Ile  Tyr Gly Phe Asp Leu  Ala Ser Ser 
    1355                 1360                 1365             


His Leu  Asp Thr Val Lys Leu  Ile Leu Asn Ile Asn  Ile Glu Ser 
    1370                 1375                 1380             


Pro Val  Val Ser Ile Pro Arg  Lys Pro Gly Ser Pro  Glu Leu Leu 
    1385                 1390                 1395             


Val Gly  His Leu Gly Gln Ile  Phe Ile Gln Asn Phe  Val Ala Gly 
    1400                 1405                 1410             


Asp Asp  Glu Ser Arg Ser Asp  Arg Leu Gln Val Glu  Ile Lys Asp 
    1415                 1420                 1425             


Ile Lys  Leu Tyr Ser Leu Asn  Cys Thr Gln Leu Ala  Gly Arg Glu 
    1430                 1435                 1440             


Ala Val  Gly Ser Glu Gly Ser  Arg Met Phe Cys Pro  Pro Ser Gly 
    1445                 1450                 1455             


Ser Gly  Ser Ala Asn Ser Gln  Glu Glu Ala His Phe  Thr Arg His 
    1460                 1465                 1470             


Asp Phe  Phe Glu Ser Leu His  Arg Gly Gln Ala Phe  His Ile Leu 
    1475                 1480                 1485             


Asn Asn  Thr Thr Ile Gln Phe  Lys Leu Glu Lys Ile  Pro Ile Glu 
    1490                 1495                 1500             


Arg Glu  Ser Glu Leu Thr Phe  Ser Leu Ser Pro Asp  Asp Leu Gly 
    1505                 1510                 1515             


Thr Ser  Ser Ile Met Lys Ile  Glu Gly Lys Phe Val  Asn Pro Val 
    1520                 1525                 1530             


Gln Val  Val Leu Ala Lys His  Val Tyr Glu Gln Val  Leu Gln Thr 
    1535                 1540                 1545             


Leu Asp  Asn Leu Val Tyr Ser  Glu Asp Leu Asn Lys  Tyr Pro Ala 
    1550                 1555                 1560             


Ser Ala  Thr Ser Ser Pro Cys  Pro Asp Ser Pro Leu  Pro Pro Leu 
    1565                 1570                 1575             


Ser Thr  Cys Gly Glu Ser Ser  Val Glu Arg Lys Glu  Asn Gly Leu 
    1580                 1585                 1590             


Phe Ser  His Ser Ser Leu Ser  Asn Thr Ser Gln Lys  Ser Leu Ser 
    1595                 1600                 1605             


Val Lys  Glu Val Lys Ser Phe  Thr Gln Ile Gln Ala  Thr Phe Cys 
    1610                 1615                 1620             


Ile Ser  Glu Leu Gln Val Gln  Leu Ser Gly Asp Leu  Thr Leu Gly 
    1625                 1630                 1635             


Ala Gln  Gly Leu Val Ser Leu  Lys Phe Gln Asp Phe  Glu Val Glu 
    1640                 1645                 1650             


Phe Ser  Lys Asp His Pro Gln  Thr Leu Ser Ile Gln  Ile Ala Leu 
    1655                 1660                 1665             


His Ser  Leu Leu Met Glu Asp  Leu Leu Glu Lys Asn  Pro Asp Ser 
    1670                 1675                 1680             


Lys Tyr  Lys Asn Leu Met Val  Ser Arg Gly Ala Pro  Lys Pro Ser 
    1685                 1690                 1695             


Ser Leu  Ala Gln Lys Glu Tyr  Leu Ser Gln Ser Cys  Pro Ser Val 
    1700                 1705                 1710             


Ser Asn  Val Glu Tyr Pro Asp  Met Pro Arg Ser Leu  Pro Ser His 
    1715                 1720                 1725             


Met Glu  Glu Ala Pro Asn Val  Phe Gln Leu Tyr Gln  Arg Pro Thr 
    1730                 1735                 1740             


Ser Ala  Ser Arg Lys Lys Gln  Lys Glu Val Gln Asp  Lys Asp Tyr 
    1745                 1750                 1755             


Pro Leu  Thr Pro Pro Pro Ser  Pro Thr Val Asp Glu  Pro Lys Ile 
    1760                 1765                 1770             


Leu Val  Gly Lys Ser Lys Phe  Asp Asp Ser Leu Val  His Ile Asn 
    1775                 1780                 1785             


Ile Phe  Leu Val Asp Lys Lys  His Pro Glu Phe Ser  Ser Ser Tyr 
    1790                 1795                 1800             


Asn Arg  Val Asn Arg Ser Ile  Asp Val Asp Phe Asn  Cys Leu Asp 
    1805                 1810                 1815             


Val Leu  Ile Thr Leu Gln Thr  Trp Val Val Ile Leu  Asp Phe Phe 
    1820                 1825                 1830             


Gly Ile  Gly Ser Thr Ala Asp  Asn His Ala Met Arg  Leu Pro Pro 
    1835                 1840                 1845             


Glu Gly  Ile Leu His Asn Val  Lys Leu Glu Pro His  Ala Ser Met 
    1850                 1855                 1860             


Glu Ser  Gly Leu Gln Asp Pro  Val Asn Thr Lys Leu  Asp Leu Lys 
    1865                 1870                 1875             


Val His  Ser Leu Ser Leu Val  Leu Asn Lys Thr Thr  Ser Glu Leu 
    1880                 1885                 1890             


Ala Lys  Ala Asn Val Ser Lys  Leu Val Ala His Leu  Glu Met Ile 
    1895                 1900                 1905             


Glu Gly  Asp Leu Ala Leu Gln  Gly Ser Ile Gly Ser  Leu Ser Leu 
    1910                 1915                 1920             


Ser Asp  Leu Thr Cys His Gly  Glu Phe Tyr Arg Glu  Arg Phe Thr 
    1925                 1930                 1935             


Thr Ser  Gly Glu Glu Ala Leu  Ile Phe Gln Thr Phe  Lys Tyr Gly 
    1940                 1945                 1950             


Arg Pro  Asp Pro Leu Leu Arg  Arg Glu His Asp Ile  Arg Val Ser 
    1955                 1960                 1965             


Leu Arg  Met Ala Ser Val Gln  Tyr Val His Thr Gln  Arg Phe Gln 
    1970                 1975                 1980             


Ala Glu  Val Val Ala Phe Ile  Gln His Phe Thr Gln  Leu Gln Asp 
    1985                 1990                 1995             


Val Leu  Gly Arg Gln Arg Ala  Ala Ile Glu Gly Gln  Thr Val Arg 
    2000                 2005                 2010             


Asp Gln  Ala Gln Arg Cys Ser  Arg Val Leu Leu Asp  Ile Glu Ala 
    2015                 2020                 2025             


Gly Ala  Pro Val Leu Leu Ile  Pro Glu Ser Ser Arg  Ser Asn Asn 
    2030                 2035                 2040             


Leu Ile  Val Ala Asn Leu Gly  Lys Leu Lys Val Lys  Asn Lys Phe 
    2045                 2050                 2055             


Leu Phe  Ala Gly Phe Pro Gly  Thr Phe Ser Leu Gln  Asp Lys Glu 
    2060                 2065                 2070             


Ser Val  Pro Ser Ala Ser Pro  Thr Gly Ile Pro Lys  His Ser Leu 
    2075                 2080                 2085             


Arg Lys  Thr Thr Ser Thr Glu  Glu Pro Arg Gly Thr  His Ser Gln 
    2090                 2095                 2100             


Gly Gln  Phe Thr Met Pro Leu  Ala Gly Met Ser Leu  Gly Ser Leu 
    2105                 2110                 2115             


Lys Ser  Glu Phe Val Pro Ser  Thr Ser Thr Lys Gln  Gln Gly Pro 
    2120                 2125                 2130             


Gln Pro  Thr Leu Ser Val Gly  Gln Glu Ser Ser Ser  Pro Glu Asp 
    2135                 2140                 2145             


His Val  Cys Leu Leu Asp Cys  Val Val Val Asp Leu  Gln Asp Met 
    2150                 2155                 2160             


Asp Ile  Phe Ala Ala Glu Arg  His Pro Arg Glu Tyr  Ser Lys Ala 
    2165                 2170                 2175             


Pro Glu  Asp Ser Ser Gly Asp  Leu Ile Phe Pro Ser  Tyr Phe Val 
    2180                 2185                 2190             


Arg Gln  Thr Gly Gly Ser Leu  Leu Thr Glu Pro Cys  Arg Leu Lys 
    2195                 2200                 2205             


Leu Gln  Val Glu Arg Asn Leu  Asp Lys Glu Ile Ser  His Thr Val 
    2210                 2215                 2220             


Pro Asp  Ile Ser Ile His Gly  Asn Leu Ser Ser Val  His Cys Ser 
    2225                 2230                 2235             


Leu Asp  Leu Tyr Lys Tyr Lys  Leu Ile Arg Gly Leu  Leu Glu Asn 
    2240                 2245                 2250             


Asn Leu  Gly Glu Pro Ile Glu  Glu Phe Met Arg Pro  Tyr Asp Leu 
    2255                 2260                 2265             


Gln Asp  Pro Arg Ile His Thr  Val Leu Ser Gly Glu  Val Tyr Thr 
    2270                 2275                 2280             


Cys Met  Cys Phe Leu Ile Asp  Met Val Asn Val Ser  Leu Glu Leu 
    2285                 2290                 2295             


Lys Asp  Pro Lys Arg Lys Glu  Gly Ala Gly Ser Leu  Ala Arg Phe 
    2300                 2305                 2310             


Asp Phe  Lys Lys Cys Lys Leu  Leu Tyr Glu Ser Phe  Ser Asn Gln 
    2315                 2320                 2325             


Thr Lys  Ser Ile Asn Leu Val  Ser His Ser Met Met  Ala Phe Asp 
    2330                 2335                 2340             


Thr Arg  Tyr Ala Gly Gln Lys  Thr Ser Pro Gly Met  Thr Asn Val 
    2345                 2350                 2355             


Phe Ser  Cys Ile Phe Gln Pro  Ala Lys Asn Ser Ser  Thr Thr Gln 
    2360                 2365                 2370             


Gly Ser  Ile Gln Ile Glu Leu  His Phe Arg Ser Thr  Lys Asp Ser 
    2375                 2380                 2385             


Ser Cys  Phe Thr Val Val Leu  Asn Asn Leu Arg Val  Phe Leu Ile 
    2390                 2395                 2400             


Phe Asp  Trp Leu Leu Leu Val  His Asp Phe Leu His  Thr Pro Ser 
    2405                 2410                 2415             


Asp Ile  Lys Lys Gln Asn His  Val Thr Pro Ser Arg  His Arg Asn 
    2420                 2425                 2430             


Ser Ser  Ser Glu Ser Ala Ile  Val Pro Lys Thr Val  Lys Ser Gly 
    2435                 2440                 2445             


Val Val  Thr Lys Arg Ser Ser  Leu Pro Val Ser Asn  Glu Arg His 
    2450                 2455                 2460             


Leu Glu  Val Lys Val Asn Val  Thr Gly Thr Glu Phe  Val Val Ile 
    2465                 2470                 2475             


Glu Asp  Val Ser Cys Phe Asp  Thr Asn Ala Ile Ile  Leu Lys Gly 
    2480                 2485                 2490             


Thr Thr  Val Leu Thr Tyr Lys  Pro Arg Phe Val Asp  Arg Pro Phe 
    2495                 2500                 2505             


Ser Gly  Ser Leu Phe Gly Ile  Glu Val Phe Ser Cys  Arg Leu Gly 
    2510                 2515                 2520             


Asn Glu  His Asp Thr Ala Leu  Ser Ile Val Asp Pro  Val Gln Ile 
    2525                 2530                 2535             


Gln Met  Glu Leu Val Gly Asn  Ser Ser Tyr Gln Asn  Ser Ser Gly 
    2540                 2545                 2550             


Leu Met  Asp Ala Phe Asn Ser  Glu Asp Phe Pro Pro  Val Leu Glu 
    2555                 2560                 2565             


Ile Gln  Leu Gln Ala Leu Asp  Ile Arg Leu Ser Tyr  Asn Asp Val 
    2570                 2575                 2580             


Gln Leu  Phe Leu Ala Ile Ala  Lys Ser Ile Pro Glu  Gln Ala Asn 
    2585                 2590                 2595             


Ala Ala  Val Pro Asp Ser Val  Ala Leu Glu Ser Asp  Ser Val Gly 
    2600                 2605                 2610             


Thr Tyr  Leu Pro Gly Ala Ser  Arg Val Gly Glu Glu  Ile Arg Glu 
    2615                 2620                 2625             


Gly Thr  Arg His Thr Leu Asp  Pro Val Leu Glu Leu  Gln Leu Ala 
    2630                 2635                 2640             


Arg Leu  Gln Glu Leu Gly Phe  Ser Met Asp Asp Cys  Arg Lys Ala 
    2645                 2650                 2655             


Leu Leu  Ala Cys Gln Gly Gln  Leu Lys Lys Ala Ala  Ser Trp Leu 
    2660                 2665                 2670             


Phe Lys  Asn Ala Glu Pro Leu  Lys Ser Leu Ser Leu  Ala Ser Thr 
    2675                 2680                 2685             


Ser Arg  Asp Ser Pro Gly Ala  Val Ala Ala Pro Leu  Ile Ser Gly 
    2690                 2695                 2700             


Val Glu  Ile Lys Ala Glu Ser  Val Cys Ile Cys Phe  Ile Asp Asp 
    2705                 2710                 2715             


Cys Met  Asp Cys Asp Val Pro  Leu Ala Glu Leu Thr  Phe Ser Arg 
    2720                 2725                 2730             


Leu Asn  Phe Leu Gln Arg Val  Arg Thr Ser Pro Glu  Gly Tyr Ala 
    2735                 2740                 2745             


His Phe  Thr Leu Ser Gly Asp  Tyr Tyr Asn Arg Ala  Leu Ser Gly 
    2750                 2755                 2760             


Trp Glu  Pro Phe Ile Glu Pro  Trp Pro Cys Ser Val  Ser Trp Gln 
    2765                 2770                 2775             


Gln Gln  Ala Ala Ser Arg Leu  His Pro Pro Arg Leu  Lys Leu Glu 
    2780                 2785                 2790             


Ala Lys  Ala Lys Pro Arg Leu  Asp Ile Asn Ile Thr  Ser Val Leu 
    2795                 2800                 2805             


Ile Asp  Gln Tyr Val Ser Thr  Lys Glu Ser Trp Met  Ala Asp Tyr 
    2810                 2815                 2820             


Cys Lys  Asp Asp Lys Asp Ile  Glu Ser Ala Lys Ser  Glu Asp Trp 
    2825                 2830                 2835             


Met Gly  Ser Ser Val Asp Pro  Pro Cys Phe Gly Gln  Ser Leu Pro 
    2840                 2845                 2850             


Leu Val  Tyr Leu Arg Thr Arg  Ser Thr Ala Ser Leu  Thr Asn Leu 
    2855                 2860                 2865             


Glu His  Gln Ile Tyr Ala Arg  Ala Glu Val Lys Thr  Pro Lys Arg 
    2870                 2875                 2880             


Arg Gln  Pro Phe Val Pro Phe  Ala Leu Arg Asn His  Thr Gly Cys 
    2885                 2890                 2895             


Thr Leu  Trp Phe Ala Thr Leu  Thr Thr Thr Pro Thr  Arg Ala Ala 
    2900                 2905                 2910             


Leu Ser  His Ser Gly Ser Pro  Gly Val Val Pro Glu  Gly Asn Gly 
    2915                 2920                 2925             


Thr Phe  Leu Asp Asp Thr His  Asn Val Ser Glu Trp  Arg Glu Val 
    2930                 2935                 2940             


Leu Thr  Gly Glu Glu Ile Pro  Phe Glu Phe Glu Ala  Arg Gly Lys 
    2945                 2950                 2955             


Leu Arg  His Arg His Thr His  Asp Leu Arg Ile His  Gln Leu Gln 
    2960                 2965                 2970             


Val Arg  Val Asn Gly Trp Glu  Gln Val Ser Pro Val  Ser Val Asp 
    2975                 2980                 2985             


Lys Val  Gly Thr Phe Phe Arg  Tyr Ala Ala Pro Asp  Lys Asn Ser 
    2990                 2995                 3000             


Ser Ser  Ser Thr Ile Gly Ser  Pro Ser Ser Arg Thr  Asn Ile Ile 
    3005                 3010                 3015             


His Pro  Gln Val Tyr Phe Ser  Ser Leu Pro Pro Val  Arg Val Val 
    3020                 3025                 3030             


Phe Ala  Val Thr Met Glu Gly  Ser Ala Arg Lys Val  Ile Thr Val 
    3035                 3040                 3045             


Arg Ser  Ala Leu Ile Val Arg  Asn Arg Leu Glu Thr  Pro Met Glu 
    3050                 3055                 3060             


Leu Arg  Leu Asp Ser Pro Ser  Ala Pro Asp Lys Pro  Val Val Leu 
    3065                 3070                 3075             


Pro Ala  Ile Met Pro Gly Asp  Ser Phe Ala Val Pro  Leu His Leu 
    3080                 3085                 3090             


Thr Ser  Trp Arg Leu Gln Ala  Arg Pro Lys Gly Leu  Gly Val Phe 
    3095                 3100                 3105             


Phe Cys  Lys Ala Pro Ile His  Trp Thr Asn Val Val  Lys Thr Ala 
    3110                 3115                 3120             


Glu Ile  Ser Ser Ser Lys Arg  Glu Cys His Ser Met  Asp Thr Glu 
    3125                 3130                 3135             


Lys Ser  Arg Phe Phe Arg Phe  Cys Val Ala Ile Lys  Lys Glu Asn 
    3140                 3145                 3150             


Tyr Pro  Asp Tyr Met Pro Ser  Asn Ile Phe Ser Asp  Ser Ala Lys 
    3155                 3160                 3165             


Gln Ile  Phe Arg Gln Pro Gly  His Thr Ile Tyr Leu  Leu Pro Thr 
    3170                 3175                 3180             


Val Val  Ile Cys Asn Leu Leu  Pro Cys Glu Leu Asp  Phe Tyr Val 
    3185                 3190                 3195             


Lys Gly  Met Pro Ile Asn Gly  Thr Leu Lys Pro Gly  Lys Glu Ala 
    3200                 3205                 3210             


Ala Leu  His Thr Ala Asp Thr  Ser Gln Asn Ile Glu  Leu Gly Val 
    3215                 3220                 3225             


Ser Leu  Glu Asn Phe Pro Leu  Cys Lys Glu Leu Leu  Ile Pro Pro 
    3230                 3235                 3240             


Gly Thr  Gln Asn Tyr Met Val  Arg Met Arg Leu Tyr  Asp Val Asn 
    3245                 3250                 3255             


Arg Arg  Gln Leu Asn Leu Thr  Ile Arg Ile Val Cys  Arg Ala Glu 
    3260                 3265                 3270             


Gly Ser  Leu Lys Ile Phe Ile  Ser Ala Pro Tyr Trp  Leu Ile Asn 
    3275                 3280                 3285             


Lys Thr  Gly Leu Pro Leu Ile  Phe Arg Gln Asp Asn  Ala Lys Thr 
    3290                 3295                 3300             


Asp Ala  Ala Gly Gln Phe Glu  Glu His Glu Leu Ala  Arg Ser Leu 
    3305                 3310                 3315             


Ser Pro  Leu Leu Phe Cys Tyr  Ala Asp Lys Glu Gln  Pro Asn Leu 
    3320                 3325                 3330             


Cys Thr  Met Arg Ile Gly Arg  Gly Ile His Pro Glu  Gly Met Pro 
    3335                 3340                 3345             


Gly Trp  Cys Gln Gly Phe Ser  Leu Asp Gly Gly Ser  Gly Val Arg 
    3350                 3355                 3360             


Ala Leu  Lys Val Ile Gln Gln  Gly Asn Arg Pro Gly  Leu Ile Tyr 
    3365                 3370                 3375             


Asn Ile  Gly Ile Asp Val Lys  Lys Gly Arg Gly Arg  Tyr Ile Asp 
    3380                 3385                 3390             


Thr Cys  Met Val Ile Phe Ala  Pro Arg Tyr Leu Leu  Asp Asn Lys 
    3395                 3400                 3405             


Ser Ser  His Lys Leu Ala Phe  Ala Gln Arg Glu Phe  Ala Arg Gly 
    3410                 3415                 3420             


Gln Gly  Thr Ala Asn Pro Glu  Gly Tyr Ile Ser Thr  Leu Pro Gly 
    3425                 3430                 3435             


Ser Ser  Val Val Phe His Trp  Pro Arg Asn Asp Tyr  Asp Gln Leu 
    3440                 3445                 3450             


Leu Cys  Val Arg Leu Met Asp  Val Pro Asn Cys Ile  Trp Ser Gly 
    3455                 3460                 3465             


Gly Phe  Glu Val Asn Lys Asn  Asn Ser Phe His Ile  Asn Met Arg 
    3470                 3475                 3480             


Asp Thr  Leu Gly Lys Cys Phe  Phe Leu Arg Val Glu  Ile Thr Leu 
    3485                 3490                 3495             


Arg Gly  Ala Thr Tyr Arg Ile  Ser Phe Ser Asp Thr  Asp Gln Leu 
    3500                 3505                 3510             


Pro Pro  Pro Phe Arg Ile Asp  Asn Phe Ser Lys Val  Pro Val Val 
    3515                 3520                 3525             


Phe Thr  Gln His Gly Val Ala  Glu Pro Arg Leu Arg  Thr Glu Val 
    3530                 3535                 3540             


Lys Pro  Met Thr Ser Leu Asp  Tyr Ala Trp Asp Glu  Pro Thr Leu 
    3545                 3550                 3555             


Pro Pro  Phe Ile Thr Leu Thr  Val Lys Gly Ala Gly  Ser Ser Glu 
    3560                 3565                 3570             


Ile Asn  Cys Asn Met Asn Asp  Phe Gln Asp Asn Arg  Gln Leu Tyr 
    3575                 3580                 3585             


Tyr Glu  Asn Phe Ile Tyr Ile  Ala Ala Thr Tyr Thr  Phe Ser Gly 
    3590                 3595                 3600             


Leu Gln  Glu Gly Thr Gly Arg  Pro Val Ala Ser Asn  Lys Ala Ile 
    3605                 3610                 3615             


Thr Cys  Ala Glu Leu Val Leu  Asp Val Ser Pro Lys  Thr Gln Arg 
    3620                 3625                 3630             


Val Ile  Leu Lys Lys Lys Glu  Pro Gly Lys Arg Ser  Gln Leu Trp 
    3635                 3640                 3645             


Arg Met  Thr Gly Thr Gly Met  Leu Ala His Glu Gly  Ser Ser Val 
    3650                 3655                 3660             


Pro His  Asn Pro Asn Lys Pro  Ser Ala Ala Arg Ser  Thr Glu Gly 
    3665                 3670                 3675             


Ser Ala  Ile Leu Asp Ile Ala  Gly Leu Ala Ala Val  Thr Asp Asn 
    3680                 3685                 3690             


Arg Tyr  Glu Pro Leu Met Leu  Arg Lys Pro Asp Arg  Arg Arg Ser 
    3695                 3700                 3705             


Thr Thr  Gln Thr Trp Ser Phe  Arg Glu Gly Lys Leu  Thr Cys Gly 
    3710                 3715                 3720             


Leu His  Gly Leu Val Val Gln  Ala Lys Gly Gly Leu  Ser Gly Leu 
    3725                 3730                 3735             


Phe Asp  Gly Ala Glu Val Val  Leu Gly Pro Asp Thr  Ser Met Glu 
    3740                 3745                 3750             


Leu Leu  Gly Pro Val Pro Pro  Glu Gln Gln Phe Ile  Asn Gln Lys 
    3755                 3760                 3765             


Met Arg  Pro Gly Ser Gly Met  Leu Ser Ile Arg Val  Ile Pro Asp 
    3770                 3775                 3780             


Gly Pro  Thr Arg Ala Leu Gln  Ile Thr Asp Phe Cys  His Arg Lys 
    3785                 3790                 3795             


Ser Ser  Arg Ser Tyr Glu Val  Asp Glu Leu Pro Val  Thr Glu Gln 
    3800                 3805                 3810             


Glu Leu  Gln Lys Leu Lys Asn  Pro Asp Thr Glu Gln  Glu Leu Glu 
    3815                 3820                 3825             


Val Leu  Val Arg Leu Glu Gly  Gly Ile Gly Leu Ser  Leu Ile Asn 
    3830                 3835                 3840             


Lys Val  Pro Glu Glu Leu Val  Phe Ala Ser Leu Thr  Gly Ile Asn 
    3845                 3850                 3855             


Val His  Tyr Thr Gln Leu Ala  Thr Ser His Met Leu  Glu Leu Ser 
    3860                 3865                 3870             


Ile Gln  Asp Val Gln Val Asp  Asn Gln Leu Ile Gly  Thr Thr Gln 
    3875                 3880                 3885             


Pro Phe  Met Leu Tyr Val Thr  Pro Leu Ser Asn Glu  Asn Glu Val 
    3890                 3895                 3900             


Ile Glu  Thr Gly Pro Ala Val  Gln Val Asn Ala Val  Lys Phe Pro 
    3905                 3910                 3915             


Ser Lys  Ser Ala Leu Thr Asn  Ile Tyr Lys His Leu  Met Ile Thr 
    3920                 3925                 3930             


Ala Gln  Arg Phe Thr Val Gln  Ile Glu Glu Lys Leu  Leu Leu Lys 
    3935                 3940                 3945             


Leu Leu  Ser Phe Phe Gly Tyr  Asp Gln Ala Glu Ser  Glu Val Glu 
    3950                 3955                 3960             


Lys Tyr  Asp Glu Asn Leu His  Glu Lys Thr Ala Glu  Gln Gly Gly 
    3965                 3970                 3975             


Thr Pro  Ile Arg Tyr Tyr Phe  Glu Asn Leu Lys Ile  Ser Ile Pro 
    3980                 3985                 3990             


Gln Ile  Lys Leu Ser Val Phe  Thr Ser Asn Lys Leu  Pro Leu Asp 
    3995                 4000                 4005             


Leu Lys  Ala Leu Lys Ser Thr  Leu Gly Phe Pro Leu  Ile Arg Phe 
    4010                 4015                 4020             


Glu Asp  Ala Val Ile Asn Leu  Asp Pro Phe Thr Arg  Val His Pro 
    4025                 4030                 4035             


Tyr Glu  Thr Lys Glu Phe Ile  Ile Asn Asp Ile Leu  Lys His Phe 
    4040                 4045                 4050             


Gln Glu  Glu Leu Leu Ser Gln  Ala Ala Arg Ile Leu  Gly Ser Val 
    4055                 4060                 4065             


Asp Phe  Leu Gly Asn Pro Met  Gly Leu Leu Asn Asp  Val Ser Glu 
    4070                 4075                 4080             


Gly Val  Thr Gly Leu Ile Lys  Tyr Gly Asn Val Gly  Gly Leu Ile 
    4085                 4090                 4095             


Arg Asn  Val Thr His Gly Val  Ser Asn Ser Ala Ala  Lys Phe Ala 
    4100                 4105                 4110             


Gly Thr  Leu Ser Asp Gly Leu  Gly Lys Thr Met Asp  Asn Arg His 
    4115                 4120                 4125             


Gln Ser  Glu Arg Glu Tyr Ile  Arg Tyr His Ala Ala  Thr Ser Gly 
    4130                 4135                 4140             


Glu His  Leu Val Ala Gly Ile  His Gly Leu Ala His  Gly Ile Ile 
    4145                 4150                 4155             


Gly Gly  Leu Thr Ser Val Ile  Thr Ser Thr Val Glu  Gly Val Lys 
    4160                 4165                 4170             


Thr Glu  Gly Gly Val Ser Gly  Phe Ile Ser Gly Leu  Gly Lys Gly 
    4175                 4180                 4185             


Leu Val  Gly Thr Val Thr Lys  Pro Val Ala Gly Ala  Leu Asp Phe 
    4190                 4195                 4200             


Ala Ser  Glu Thr Ala Gln Ala  Val Arg Asp Thr Ala  Thr Leu Ser 
    4205                 4210                 4215             


Gly Pro  Arg Thr Gln Ala Gln  Arg Val Arg Lys Pro  Arg Cys Cys 
    4220                 4225                 4230             


Thr Gly  Pro Gln Gly Leu Leu  Pro Arg Tyr Ser Glu  Ser Gln Ala 
    4235                 4240                 4245             


Glu Gly  Gln Glu Gln Leu Phe  Lys Leu Thr Asp Asn  Ile Gln Asp 
    4250                 4255                 4260             


Glu Phe  Phe Ile Ala Val Glu  Asn Ile Asp Ser Tyr  Cys Val Leu 
    4265                 4270                 4275             


Ile Ser  Ser Lys Ala Val Tyr  Phe Leu Lys Ser Gly  Asp Tyr Val 
    4280                 4285                 4290             


Asp Arg  Glu Ala Ile Phe Leu  Glu Val Lys Tyr Asp  Asp Leu Tyr 
    4295                 4300                 4305             


His Cys  Leu Val Ser Lys Asp  His Gly Lys Val Tyr  Val Gln Val 
    4310                 4315                 4320             


Thr Lys  Lys Ala Val Ser Thr  Ser Ser Gly Val Ser  Ile Pro Gly 
    4325                 4330                 4335             


Pro Ser  His Gln Lys Pro Met  Val His Val Lys Ser  Glu Val Leu 
    4340                 4345                 4350             


Ala Val  Lys Leu Ser Gln Glu  Ile Asn Tyr Ala Lys  Ser Leu Tyr 
    4355                 4360                 4365             


Tyr Glu  Gln Gln Leu Met Leu  Arg Leu Ser Glu Asn  Arg Glu Gln 
    4370                 4375                 4380             


Leu Glu  Leu Asp Ser 
    4385             


<210>  4
<211>  4363
<212>  PRT
<213>  Homo Sapiens

<400>  4

Met Leu Glu Gly Leu Val Ala Trp Val Leu Asn Thr Tyr Leu Gly Lys 
1               5                   10                  15      


Tyr Val Asn Asn Leu Asn Thr Asp Gln Leu Ser Val Ala Leu Leu Lys 
            20                  25                  30          


Gly Ala Val Glu Leu Glu Asn Leu Pro Leu Lys Lys Asp Ala Leu Lys 
        35                  40                  45              


Glu Leu Glu Leu Pro Phe Glu Val Lys Ala Gly Phe Ile Gly Lys Val 
    50                  55                  60                  


Thr Leu Gln Ile Pro Phe Tyr Arg Pro His Val Asp Pro Trp Val Ile 
65                  70                  75                  80  


Ser Ile Ser Ser Leu His Leu Ile Gly Ala Pro Glu Lys Ile Gln Asp 
                85                  90                  95      


Phe Asn Asp Glu Lys Glu Lys Leu Leu Glu Arg Glu Arg Lys Lys Ala 
            100                 105                 110         


Leu Leu Gln Ala Leu Glu Glu Lys Trp Lys Asn Asp Arg Gln Gln Lys 
        115                 120                 125             


Gly Glu Ser Tyr Trp Tyr Ser Val Thr Ala Ser Val Val Thr Arg Ile 
    130                 135                 140                 


Val Glu Asn Ile Glu Leu Lys Ile Gln Asp Val His Leu Arg Phe Glu 
145                 150                 155                 160 


Asp Gly Val Thr Asn Pro Ser His Pro Phe Ala Phe Gly Ile Cys Ile 
                165                 170                 175     


Lys Asn Val Ser Met Gln Asn Ala Val Asn Glu Pro Val Gln Lys Leu 
            180                 185                 190         


Met Arg Lys Lys Gln Leu Asp Val Ala Glu Phe Ser Ile Tyr Trp Asp 
        195                 200                 205             


Val Asp Cys Thr Leu Leu Gly Asp Leu Pro Gln Met Glu Leu Gln Glu 
    210                 215                 220                 


Ala Met Ala Arg Ser Met Glu Ser Arg Ser His His Tyr Val Leu Glu 
225                 230                 235                 240 


Pro Val Phe Ala Ser Ala Leu Leu Lys Arg Asn Cys Ser Lys Lys Pro 
                245                 250                 255     


Leu Arg Ser Arg His Ser Pro Arg Ile Asp Cys Asp Ile Gln Leu Glu 
            260                 265                 270         


Thr Ile Pro Leu Lys Leu Ser Gln Leu Gln Tyr Arg Gln Ile Met Glu 
        275                 280                 285             


Phe Leu Lys Glu Leu Glu Arg Lys Glu Arg Gln Val Lys Phe Arg Arg 
    290                 295                 300                 


Trp Lys Pro Lys Val Ala Ile Ser Lys Asn Cys Arg Glu Trp Trp Tyr 
305                 310                 315                 320 


Phe Ala Leu Asn Ala Asn Leu Tyr Glu Ile Arg Glu Gln Arg Lys Arg 
                325                 330                 335     


Cys Thr Trp Asp Phe Met Leu His Arg Ala Arg Asp Ala Val Ser Tyr 
            340                 345                 350         


Thr Asp Lys Tyr Phe Asn Lys Leu Lys Gly Gly Leu Leu Ser Thr Asp 
        355                 360                 365             


Asp Lys Glu Glu Met Cys Arg Ile Glu Glu Glu Gln Ser Phe Glu Glu 
    370                 375                 380                 


Leu Lys Ile Leu Arg Glu Leu Val His Asp Arg Phe His Lys Gln Glu 
385                 390                 395                 400 


Glu Leu Ala Glu Ser Leu Arg Glu Pro Gln Phe Asp Ser Pro Gly Ala 
                405                 410                 415     


Cys Pro Gly Ala Pro Glu Pro Gly Gly Gly Ser Gly Met Leu Gln Tyr 
            420                 425                 430         


Leu Gln Ser Trp Phe Pro Gly Trp Gly Gly Trp Tyr Gly Gln Gln Thr 
        435                 440                 445             


Pro Glu Gly Asn Val Val Glu Gly Leu Ser Ala Glu Gln Gln Glu Gln 
    450                 455                 460                 


Trp Ile Pro Glu Glu Ile Leu Gly Thr Glu Glu Phe Phe Asp Pro Thr 
465                 470                 475                 480 


Ala Asp Ala Ser Cys Met Asn Thr Tyr Thr Lys Arg Asp His Val Phe 
                485                 490                 495     


Ala Lys Leu Asn Leu Gln Leu Gln Arg Gly Thr Val Thr Leu Leu His 
            500                 505                 510         


Lys Glu Gln Gly Thr Pro Gln Met Asn Glu Ser Ala Phe Met Gln Leu 
        515                 520                 525             


Glu Phe Ser Asp Val Lys Leu Leu Ala Glu Ser Leu Pro Arg Arg Asn 
    530                 535                 540                 


Ser Ser Leu Leu Ser Val Arg Leu Gly Gly Leu Phe Leu Arg Asp Leu 
545                 550                 555                 560 


Ala Thr Glu Gly Thr Met Phe Pro Leu Leu Val Phe Pro Asn Pro Gln 
                565                 570                 575     


Lys Glu Val Gly Arg Val Ser Gln Ser Phe Gly Leu Gln Thr Thr Ser 
            580                 585                 590         


Ala Asp Arg Ser Asp His Tyr Pro Ala Ala Asp Pro Asp Gly Pro Val 
        595                 600                 605             


Phe Glu Met Leu Tyr Glu Arg Asn Pro Ala His Ser His Phe Glu Arg 
    610                 615                 620                 


Arg Leu Asn Val Ser Thr Arg Pro Leu Asn Ile Ile Tyr Asn Pro Gln 
625                 630                 635                 640 


Ala Ile Lys Lys Val Ala Asp Phe Phe Tyr Lys Gly Lys Val His Thr 
                645                 650                 655     


Ser Gly Phe Gly Tyr Gln Ser Glu Leu Glu Leu Arg Val Ala Glu Ala 
            660                 665                 670         


Ala Arg Arg Gln Tyr Asn Lys Leu Lys Met Gln Thr Lys Ala Glu Ile 
        675                 680                 685             


Arg Gln Thr Leu Asp Arg Leu Leu Val Gly Asp Phe Ile Glu Glu Ser 
    690                 695                 700                 


Lys Arg Trp Thr Val Arg Leu Asp Ile Ser Ala Pro Gln Val Ile Phe 
705                 710                 715                 720 


Pro Asp Asp Phe Lys Phe Lys Asn Pro Val Leu Val Val Val Asp Leu 
                725                 730                 735     


Gly Arg Met Leu Leu Thr Asn Thr Gln Asp Asn Ser Arg Arg Lys Ser 
            740                 745                 750         


Arg Asp Gly Ser Ala Ser Glu Glu Thr Gln Phe Ser Asp Asp Glu Tyr 
        755                 760                 765             


Lys Thr Pro Leu Ala Thr Pro Pro Asn Thr Pro Pro Pro Glu Ser Ser 
    770                 775                 780                 


Ser Ser Asn Gly Glu Lys Thr Pro Pro Phe Ser Gly Val Glu Phe Ser 
785                 790                 795                 800 


Glu Glu Gln Leu Gln Ala His Leu Met Ser Thr Lys Met Tyr Glu Arg 
                805                 810                 815     


Tyr Ser Leu Ser Phe Met Asp Leu Gln Ile Met Val Gly Arg Val Lys 
            820                 825                 830         


Asp Asn Trp Lys His Val Gln Asp Ile Asp Val Gly Pro Thr His Val 
        835                 840                 845             


Val Glu Lys Phe Asn Val His Leu Gln Leu Glu Arg Arg Leu Ile Tyr 
    850                 855                 860                 


Thr Ser Asp Pro Lys Tyr Pro Gly Ala Val Leu Ser Gly Asn Leu Pro 
865                 870                 875                 880 


Asp Leu Lys Ile His Ile Asn Glu Asp Lys Ile Ser Ala Leu Lys Asn 
                885                 890                 895     


Cys Phe Ala Leu Leu Thr Thr Pro Glu Met Lys Thr Ser Asp Thr Gln 
            900                 905                 910         


Ile Lys Glu Lys Ile Phe Pro Gln Glu Glu Gln Arg Gly Ser Leu Gln 
        915                 920                 925             


Asp Ser Val Met Asn Leu Thr Gln Ser Ile Val Leu Leu Glu Gln His 
    930                 935                 940                 


Thr Arg Glu Val Leu Val Glu Ser Gln Leu Leu Leu Ala Glu Phe Lys 
945                 950                 955                 960 


Val Asn Cys Met Gln Leu Gly Val Glu Ser Asn Gly Arg Tyr Ile Ser 
                965                 970                 975     


Val Leu Lys Val Phe Gly Thr Asn Ala His Phe Val Lys Arg Pro Tyr 
            980                 985                 990         


Asp Ala Glu Val Ser Leu Thr Val  His Gly Leu Leu Leu  Val Asp Thr 
        995                 1000                 1005             


Met Gln  Thr Tyr Gly Ala Asp  Phe Asp Leu Leu Met  Ala Ser His 
    1010                 1015                 1020             


Lys Asn  Leu Ser Phe Asp Ile  Pro Thr Gly Ser Leu  Arg Asp Ser 
    1025                 1030                 1035             


Arg Ala  Gln Ser Pro Val Ser  Gly Pro Asn Val Ala  His Leu Thr 
    1040                 1045                 1050             


Asp Gly  Ala Thr Leu Asn Asp  Arg Ser Ala Thr Ser  Val Ser Leu 
    1055                 1060                 1065             


Asp Lys  Ile Leu Thr Lys Glu  Gln Glu Ser Leu Ile  Lys Leu Glu 
    1070                 1075                 1080             


Tyr Gln  Phe Val Ser Ser Glu  Cys Pro Ser Met Asn  Leu Asp Ser 
    1085                 1090                 1095             


Thr Leu  Gln Val Ile Ser Leu  Gln Val Asn Asn Leu  Asp Ile Ile 
    1100                 1105                 1110             


Leu Asn  Pro Glu Thr Ile Val  Glu Leu Ile Gly Phe  Leu Gln Lys 
    1115                 1120                 1125             


Ser Phe  Pro Lys Glu Lys Asp  Asp Leu Ser Pro Gln  Pro Leu Met 
    1130                 1135                 1140             


Thr Asp  Phe Glu Arg Ser Phe  Arg Glu Gln Gly Thr  Tyr Gln Ser 
    1145                 1150                 1155             


Thr Tyr  Glu Gln Asn Thr Glu  Val Ala Val Glu Ile  His Arg Leu 
    1160                 1165                 1170             


Asn Leu  Leu Leu Leu Arg Thr  Val Gly Met Ala Asn  Arg Glu Lys 
    1175                 1180                 1185             


Tyr Gly  Arg Lys Ile Ala Thr  Ala Ser Ile Gly Gly  Thr Lys Val 
    1190                 1195                 1200             


Asn Val  Ser Met Gly Ser Thr  Phe Asp Met Asn Gly  Ser Leu Gly 
    1205                 1210                 1215             


Cys Leu  Gln Leu Met Asp Leu  Thr Gln Asp Asn Val  Lys Asn Gln 
    1220                 1225                 1230             


Tyr Val  Val Ser Ile Gly Asn  Ser Val Gly Tyr Glu  Asn Ile Ile 
    1235                 1240                 1245             


Ser Asp  Ile Gly Tyr Phe Glu  Ser Val Phe Val Arg  Met Glu Asp 
    1250                 1255                 1260             


Ala Ala  Leu Thr Glu Ala Leu  Ser Phe Thr Phe Val  Glu Arg Ser 
    1265                 1270                 1275             


Lys Gln  Glu Cys Phe Leu Asn  Leu Lys Met Ala Ser  Leu His Tyr 
    1280                 1285                 1290             


Asn His  Ser Ala Lys Phe Leu  Lys Glu Leu Thr Leu  Ser Met Asp 
    1295                 1300                 1305             


Glu Leu  Glu Glu Asn Phe Arg  Gly Met Leu Lys Ser  Ala Ala Thr 
    1310                 1315                 1320             


Lys Val  Thr Thr Val Leu Ala  Thr Lys Thr Ala Glu  Tyr Ser Glu 
    1325                 1330                 1335             


Met Val  Ser Leu Phe Glu Thr  Pro Arg Lys Thr Arg  Glu Pro Phe 
    1340                 1345                 1350             


Ile Leu  Glu Glu Asn Glu Ile  Tyr Gly Phe Asp Leu  Ala Ser Ser 
    1355                 1360                 1365             


His Leu  Asp Thr Val Lys Leu  Ile Leu Asn Ile Asn  Ile Glu Ser 
    1370                 1375                 1380             


Pro Val  Val Ser Ile Pro Arg  Lys Pro Gly Ser Pro  Glu Leu Leu 
    1385                 1390                 1395             


Val Gly  His Leu Gly Gln Ile  Phe Ile Gln Asn Phe  Val Ala Gly 
    1400                 1405                 1410             


Asp Asp  Glu Ser Arg Ser Asp  Arg Leu Gln Val Glu  Ile Lys Asp 
    1415                 1420                 1425             


Ile Lys  Leu Tyr Ser Leu Asn  Cys Thr Gln Leu Ala  Gly Arg Glu 
    1430                 1435                 1440             


Ala Val  Gly Ser Glu Gly Ser  Arg Met Phe Cys Pro  Pro Ser Gly 
    1445                 1450                 1455             


Ser Gly  Ser Ala Asn Ser Gln  Glu Glu Ala His Phe  Thr Arg His 
    1460                 1465                 1470             


Asp Phe  Phe Glu Ser Leu His  Arg Gly Gln Ala Phe  His Ile Leu 
    1475                 1480                 1485             


Asn Asn  Thr Thr Ile Gln Phe  Lys Leu Glu Lys Ile  Pro Ile Glu 
    1490                 1495                 1500             


Arg Glu  Ser Glu Leu Thr Phe  Ser Leu Ser Pro Asp  Asp Leu Gly 
    1505                 1510                 1515             


Thr Ser  Ser Ile Met Lys Ile  Glu Gly Lys Phe Val  Asn Pro Val 
    1520                 1525                 1530             


Gln Val  Val Leu Ala Lys His  Val Tyr Glu Gln Val  Leu Gln Thr 
    1535                 1540                 1545             


Leu Asp  Asn Leu Val Tyr Ser  Glu Asp Leu Asn Lys  Tyr Pro Ala 
    1550                 1555                 1560             


Ser Ala  Thr Ser Ser Pro Cys  Pro Asp Ser Pro Leu  Pro Pro Leu 
    1565                 1570                 1575             


Ser Thr  Cys Gly Glu Ser Ser  Val Glu Arg Lys Glu  Asn Gly Leu 
    1580                 1585                 1590             


Phe Ser  His Ser Ser Leu Ser  Asn Thr Ser Gln Lys  Ser Leu Ser 
    1595                 1600                 1605             


Val Lys  Glu Val Lys Ser Phe  Thr Gln Ile Gln Ala  Thr Phe Cys 
    1610                 1615                 1620             


Ile Ser  Glu Leu Gln Val Gln  Leu Ser Gly Asp Leu  Thr Leu Gly 
    1625                 1630                 1635             


Ala Gln  Gly Leu Val Ser Leu  Lys Phe Gln Asp Phe  Glu Val Glu 
    1640                 1645                 1650             


Phe Ser  Lys Asp His Pro Gln  Thr Leu Ser Ile Gln  Ile Ala Leu 
    1655                 1660                 1665             


His Ser  Leu Leu Met Glu Asp  Leu Leu Glu Lys Asn  Pro Asp Ser 
    1670                 1675                 1680             


Lys Tyr  Lys Asn Leu Met Val  Ser Arg Gly Ala Pro  Lys Pro Ser 
    1685                 1690                 1695             


Ser Leu  Ala Gln Lys Glu Tyr  Leu Ser Gln Ser Cys  Pro Ser Val 
    1700                 1705                 1710             


Ser Asn  Val Glu Tyr Pro Asp  Met Pro Arg Ser Leu  Pro Ser His 
    1715                 1720                 1725             


Met Glu  Glu Ala Pro Asn Val  Phe Gln Leu Tyr Gln  Arg Pro Thr 
    1730                 1735                 1740             


Ser Ala  Ser Arg Lys Lys Gln  Lys Glu Val Gln Asp  Lys Asp Tyr 
    1745                 1750                 1755             


Pro Leu  Thr Pro Pro Pro Ser  Pro Thr Val Asp Glu  Pro Lys Ile 
    1760                 1765                 1770             


Leu Val  Gly Lys Ser Lys Phe  Asp Asp Ser Leu Val  His Ile Asn 
    1775                 1780                 1785             


Ile Phe  Leu Val Asp Lys Lys  His Pro Glu Phe Ser  Ser Ser Tyr 
    1790                 1795                 1800             


Asn Arg  Val Asn Arg Ser Ile  Asp Val Asp Phe Asn  Cys Leu Asp 
    1805                 1810                 1815             


Val Leu  Ile Thr Leu Gln Thr  Trp Val Val Ile Leu  Asp Phe Phe 
    1820                 1825                 1830             


Gly Ile  Gly Ser Thr Ala Asp  Asn His Ala Met Arg  Leu Pro Pro 
    1835                 1840                 1845             


Glu Gly  Ile Leu His Asn Val  Lys Leu Glu Pro His  Ala Ser Met 
    1850                 1855                 1860             


Glu Ser  Gly Leu Gln Asp Pro  Val Asn Thr Lys Leu  Asp Leu Lys 
    1865                 1870                 1875             


Val His  Ser Leu Ser Leu Val  Leu Asn Lys Thr Thr  Ser Glu Leu 
    1880                 1885                 1890             


Ala Lys  Ala Asn Val Ser Lys  Leu Val Ala His Leu  Glu Met Ile 
    1895                 1900                 1905             


Glu Gly  Asp Leu Ala Leu Gln  Gly Ser Ile Gly Ser  Leu Ser Leu 
    1910                 1915                 1920             


Ser Asp  Leu Thr Cys His Gly  Glu Phe Tyr Arg Glu  Arg Phe Thr 
    1925                 1930                 1935             


Thr Ser  Gly Glu Glu Ala Leu  Ile Phe Gln Thr Phe  Lys Tyr Gly 
    1940                 1945                 1950             


Arg Pro  Asp Pro Leu Leu Arg  Arg Glu His Asp Ile  Arg Val Ser 
    1955                 1960                 1965             


Leu Arg  Met Ala Ser Val Gln  Tyr Val His Thr Gln  Arg Phe Gln 
    1970                 1975                 1980             


Ala Glu  Val Val Ala Phe Ile  Gln His Phe Thr Gln  Leu Gln Asp 
    1985                 1990                 1995             


Val Leu  Gly Arg Gln Arg Ala  Ala Ile Glu Gly Gln  Thr Val Arg 
    2000                 2005                 2010             


Asp Gln  Ala Gln Arg Cys Ser  Arg Val Leu Leu Asp  Ile Glu Ala 
    2015                 2020                 2025             


Gly Ala  Pro Val Leu Leu Ile  Pro Glu Ser Ser Arg  Ser Asn Asn 
    2030                 2035                 2040             


Leu Ile  Val Ala Asn Leu Gly  Lys Leu Lys Val Lys  Asn Lys Phe 
    2045                 2050                 2055             


Leu Phe  Ala Gly Phe Pro Gly  Thr Phe Ser Leu Gln  Asp Lys Glu 
    2060                 2065                 2070             


Ser Val  Pro Ser Ala Ser Pro  Thr Gly Ile Pro Lys  His Ser Leu 
    2075                 2080                 2085             


Arg Lys  Thr Thr Ser Thr Glu  Glu Pro Arg Gly Thr  His Ser Gln 
    2090                 2095                 2100             


Gly Gln  Phe Thr Met Pro Leu  Ala Gly Met Ser Leu  Gly Ser Leu 
    2105                 2110                 2115             


Lys Ser  Glu Phe Val Pro Ser  Thr Ser Thr Lys Gln  Gln Gly Pro 
    2120                 2125                 2130             


Gln Pro  Thr Leu Ser Val Gly  Gln Glu Ser Ser Ser  Pro Glu Asp 
    2135                 2140                 2145             


His Val  Cys Leu Leu Asp Cys  Val Val Val Asp Leu  Gln Asp Met 
    2150                 2155                 2160             


Asp Ile  Phe Ala Ala Glu Arg  His Pro Arg Glu Tyr  Ser Lys Ala 
    2165                 2170                 2175             


Pro Glu  Asp Ser Ser Gly Asp  Leu Ile Phe Pro Ser  Tyr Phe Val 
    2180                 2185                 2190             


Arg Gln  Thr Gly Gly Ser Leu  Leu Thr Glu Pro Cys  Arg Leu Lys 
    2195                 2200                 2205             


Leu Gln  Val Glu Arg Asn Leu  Asp Lys Glu Ile Ser  His Thr Val 
    2210                 2215                 2220             


Pro Asp  Ile Ser Ile His Gly  Asn Leu Ser Ser Val  His Cys Ser 
    2225                 2230                 2235             


Leu Asp  Leu Tyr Lys Tyr Lys  Leu Ile Arg Gly Leu  Leu Glu Asn 
    2240                 2245                 2250             


Asn Leu  Gly Glu Pro Ile Glu  Glu Phe Met Arg Pro  Tyr Asp Leu 
    2255                 2260                 2265             


Gln Asp  Pro Arg Ile His Thr  Val Leu Ser Gly Glu  Val Tyr Thr 
    2270                 2275                 2280             


Cys Met  Cys Phe Leu Ile Asp  Met Val Asn Val Ser  Leu Glu Leu 
    2285                 2290                 2295             


Lys Asp  Pro Lys Arg Lys Glu  Gly Ala Gly Ser Leu  Ala Arg Phe 
    2300                 2305                 2310             


Asp Phe  Lys Lys Cys Lys Leu  Leu Tyr Glu Ser Phe  Ser Asn Gln 
    2315                 2320                 2325             


Thr Lys  Ser Ile Asn Leu Val  Ser His Ser Met Met  Ala Phe Asp 
    2330                 2335                 2340             


Thr Arg  Tyr Ala Gly Gln Lys  Thr Ser Pro Gly Met  Thr Asn Val 
    2345                 2350                 2355             


Phe Ser  Cys Ile Phe Gln Pro  Ala Lys Asn Ser Ser  Thr Thr Gln 
    2360                 2365                 2370             


Gly Ser  Ile Gln Ile Glu Leu  His Phe Arg Ser Thr  Lys Asp Ser 
    2375                 2380                 2385             


Ser Cys  Phe Thr Val Val Leu  Asn Asn Leu Arg Val  Phe Leu Ile 
    2390                 2395                 2400             


Phe Asp  Trp Leu Leu Leu Val  His Asp Phe Leu His  Thr Pro Ser 
    2405                 2410                 2415             


Asp Ile  Lys Lys Gln Asn His  Val Thr Pro Ser Arg  His Arg Asn 
    2420                 2425                 2430             


Ser Ser  Ser Glu Ser Ala Ile  Val Pro Lys Thr Val  Lys Ser Gly 
    2435                 2440                 2445             


Val Val  Thr Lys Arg Ser Ser  Leu Pro Val Ser Asn  Glu Arg His 
    2450                 2455                 2460             


Leu Glu  Val Lys Val Asn Val  Thr Gly Thr Glu Phe  Val Val Ile 
    2465                 2470                 2475             


Glu Asp  Val Ser Cys Phe Asp  Thr Asn Ala Ile Ile  Leu Lys Gly 
    2480                 2485                 2490             


Thr Thr  Val Leu Thr Tyr Lys  Pro Arg Phe Val Asp  Arg Pro Phe 
    2495                 2500                 2505             


Ser Gly  Ser Leu Phe Gly Ile  Glu Val Phe Ser Cys  Arg Leu Gly 
    2510                 2515                 2520             


Asn Glu  His Asp Thr Ala Leu  Ser Ile Val Asp Pro  Val Gln Ile 
    2525                 2530                 2535             


Gln Met  Glu Leu Val Gly Asn  Ser Ser Tyr Gln Asn  Ser Ser Gly 
    2540                 2545                 2550             


Leu Met  Asp Ala Phe Asn Ser  Glu Asp Phe Pro Pro  Val Leu Glu 
    2555                 2560                 2565             


Ile Gln  Leu Gln Ala Leu Asp  Ile Arg Leu Ser Tyr  Asn Asp Val 
    2570                 2575                 2580             


Gln Leu  Phe Leu Ala Ile Ala  Lys Ser Ile Pro Glu  Gln Ala Asn 
    2585                 2590                 2595             


Ala Ala  Val Pro Asp Ser Val  Ala Leu Glu Ser Asp  Ser Val Gly 
    2600                 2605                 2610             


Thr Tyr  Leu Pro Gly Ala Ser  Arg Val Gly Glu Glu  Ile Arg Glu 
    2615                 2620                 2625             


Gly Thr  Arg His Thr Leu Asp  Pro Val Leu Glu Leu  Gln Leu Ala 
    2630                 2635                 2640             


Arg Leu  Gln Glu Leu Gly Phe  Ser Met Asp Asp Cys  Arg Lys Ala 
    2645                 2650                 2655             


Leu Leu  Ala Cys Gln Gly Gln  Leu Lys Lys Ala Ala  Ser Trp Leu 
    2660                 2665                 2670             


Phe Lys  Asn Ala Glu Pro Leu  Lys Ser Leu Ser Leu  Ala Ser Thr 
    2675                 2680                 2685             


Ser Arg  Asp Ser Pro Gly Ala  Val Ala Ala Pro Leu  Ile Ser Gly 
    2690                 2695                 2700             


Val Glu  Ile Lys Ala Glu Ser  Val Cys Ile Cys Phe  Ile Asp Asp 
    2705                 2710                 2715             


Cys Met  Asp Cys Asp Val Pro  Leu Ala Glu Leu Thr  Phe Ser Arg 
    2720                 2725                 2730             


Leu Asn  Phe Leu Gln Arg Val  Arg Thr Ser Pro Glu  Gly Tyr Ala 
    2735                 2740                 2745             


His Phe  Thr Leu Ser Gly Asp  Tyr Tyr Asn Arg Ala  Leu Ser Gly 
    2750                 2755                 2760             


Trp Glu  Pro Phe Ile Glu Pro  Trp Pro Cys Ser Val  Ser Trp Gln 
    2765                 2770                 2775             


Gln Gln  Ala Ala Ser Arg Leu  His Pro Pro Arg Leu  Lys Leu Glu 
    2780                 2785                 2790             


Ala Lys  Ala Lys Pro Arg Leu  Asp Ile Asn Ile Thr  Ser Val Leu 
    2795                 2800                 2805             


Ile Asp  Gln Tyr Val Ser Thr  Lys Glu Ser Trp Met  Ala Asp Tyr 
    2810                 2815                 2820             


Cys Lys  Asp Asp Lys Asp Ile  Glu Ser Ala Lys Ser  Glu Asp Trp 
    2825                 2830                 2835             


Met Gly  Ser Ser Val Asp Pro  Pro Cys Phe Gly Gln  Thr Glu Val 
    2840                 2845                 2850             


Lys Thr  Pro Lys Arg Arg Gln  Pro Phe Val Pro Phe  Ala Leu Arg 
    2855                 2860                 2865             


Asn His  Thr Gly Cys Thr Leu  Trp Phe Ala Thr Leu  Thr Thr Thr 
    2870                 2875                 2880             


Pro Thr  Arg Ala Ala Leu Ser  His Ser Gly Ser Pro  Gly Val Val 
    2885                 2890                 2895             


Pro Glu  Gly Asn Gly Thr Phe  Leu Asp Asp Thr His  Asn Val Ser 
    2900                 2905                 2910             


Glu Trp  Arg Glu Val Leu Thr  Gly Glu Glu Ile Pro  Phe Glu Phe 
    2915                 2920                 2925             


Glu Ala  Arg Gly Lys Leu Arg  His Arg His Thr His  Asp Leu Arg 
    2930                 2935                 2940             


Ile His  Gln Leu Gln Val Arg  Val Asn Gly Trp Glu  Gln Val Ser 
    2945                 2950                 2955             


Pro Val  Ser Val Asp Lys Val  Gly Thr Phe Phe Arg  Tyr Ala Ala 
    2960                 2965                 2970             


Pro Asp  Lys Asn Ser Ser Ser  Ser Thr Ile Gly Ser  Pro Ser Ser 
    2975                 2980                 2985             


Arg Thr  Asn Ile Ile His Pro  Gln Val Tyr Phe Ser  Ser Leu Pro 
    2990                 2995                 3000             


Pro Val  Arg Val Val Phe Ala  Val Thr Met Glu Gly  Ser Ala Arg 
    3005                 3010                 3015             


Lys Val  Ile Thr Val Arg Ser  Ala Leu Ile Val Arg  Asn Arg Leu 
    3020                 3025                 3030             


Glu Thr  Pro Met Glu Leu Arg  Leu Asp Ser Pro Ser  Ala Pro Asp 
    3035                 3040                 3045             


Lys Pro  Val Val Leu Pro Ala  Ile Met Pro Gly Asp  Ser Phe Ala 
    3050                 3055                 3060             


Val Pro  Leu His Leu Thr Ser  Trp Arg Leu Gln Ala  Arg Pro Lys 
    3065                 3070                 3075             


Gly Leu  Gly Val Phe Phe Cys  Lys Ala Pro Ile His  Trp Thr Asn 
    3080                 3085                 3090             


Val Val  Lys Thr Ala Glu Ile  Ser Ser Ser Lys Arg  Glu Cys His 
    3095                 3100                 3105             


Ser Met  Asp Thr Glu Lys Ser  Arg Phe Phe Arg Phe  Cys Val Ala 
    3110                 3115                 3120             


Ile Lys  Lys Glu Asn Tyr Pro  Asp Tyr Met Pro Ser  Asn Ile Phe 
    3125                 3130                 3135             


Ser Asp  Ser Ala Lys Gln Ile  Phe Arg Gln Pro Gly  His Thr Ile 
    3140                 3145                 3150             


Tyr Leu  Leu Pro Thr Val Val  Ile Cys Asn Leu Leu  Pro Cys Glu 
    3155                 3160                 3165             


Leu Asp  Phe Tyr Val Lys Gly  Met Pro Ile Asn Gly  Thr Leu Lys 
    3170                 3175                 3180             


Pro Gly  Lys Glu Ala Ala Leu  His Thr Ala Asp Thr  Ser Gln Asn 
    3185                 3190                 3195             


Ile Glu  Leu Gly Val Ser Leu  Glu Asn Phe Pro Leu  Cys Lys Glu 
    3200                 3205                 3210             


Leu Leu  Ile Pro Pro Gly Thr  Gln Asn Tyr Met Val  Arg Met Arg 
    3215                 3220                 3225             


Leu Tyr  Asp Val Asn Arg Arg  Gln Leu Asn Leu Thr  Ile Arg Ile 
    3230                 3235                 3240             


Val Cys  Arg Ala Glu Gly Ser  Leu Lys Ile Phe Ile  Ser Ala Pro 
    3245                 3250                 3255             


Tyr Trp  Leu Ile Asn Lys Thr  Gly Leu Pro Leu Ile  Phe Arg Gln 
    3260                 3265                 3270             


Asp Asn  Ala Lys Thr Asp Ala  Ala Gly Gln Phe Glu  Glu His Glu 
    3275                 3280                 3285             


Leu Ala  Arg Ser Leu Ser Pro  Leu Leu Phe Cys Tyr  Ala Asp Lys 
    3290                 3295                 3300             


Glu Gln  Pro Asn Leu Cys Thr  Met Arg Ile Gly Arg  Gly Ile His 
    3305                 3310                 3315             


Pro Glu  Gly Met Pro Gly Trp  Cys Gln Gly Phe Ser  Leu Asp Gly 
    3320                 3325                 3330             


Gly Ser  Gly Val Arg Ala Leu  Lys Val Ile Gln Gln  Gly Asn Arg 
    3335                 3340                 3345             


Pro Gly  Leu Ile Tyr Asn Ile  Gly Ile Asp Val Lys  Lys Gly Arg 
    3350                 3355                 3360             


Gly Arg  Tyr Ile Asp Thr Cys  Met Val Ile Phe Ala  Pro Arg Tyr 
    3365                 3370                 3375             


Leu Leu  Asp Asn Lys Ser Ser  His Lys Leu Ala Phe  Ala Gln Arg 
    3380                 3385                 3390             


Glu Phe  Ala Arg Gly Gln Gly  Thr Ala Asn Pro Glu  Gly Tyr Ile 
    3395                 3400                 3405             


Ser Thr  Leu Pro Gly Ser Ser  Val Val Phe His Trp  Pro Arg Asn 
    3410                 3415                 3420             


Asp Tyr  Asp Gln Leu Leu Cys  Val Arg Leu Met Asp  Val Pro Asn 
    3425                 3430                 3435             


Cys Ile  Trp Ser Gly Gly Phe  Glu Val Asn Lys Asn  Asn Ser Phe 
    3440                 3445                 3450             


His Ile  Asn Met Arg Asp Thr  Leu Gly Lys Cys Phe  Phe Leu Arg 
    3455                 3460                 3465             


Val Glu  Ile Thr Leu Arg Gly  Ala Thr Tyr Arg Ile  Ser Phe Ser 
    3470                 3475                 3480             


Asp Thr  Asp Gln Leu Pro Pro  Pro Phe Arg Ile Asp  Asn Phe Ser 
    3485                 3490                 3495             


Lys Val  Pro Val Val Phe Thr  Gln His Gly Val Ala  Glu Pro Arg 
    3500                 3505                 3510             


Leu Arg  Thr Glu Val Lys Pro  Met Thr Ser Leu Asp  Tyr Ala Trp 
    3515                 3520                 3525             


Asp Glu  Pro Thr Leu Pro Pro  Phe Ile Thr Leu Thr  Val Lys Gly 
    3530                 3535                 3540             


Ala Gly  Ser Ser Glu Ile Asn  Cys Asn Met Asn Asp  Phe Gln Asp 
    3545                 3550                 3555             


Asn Arg  Gln Leu Tyr Tyr Glu  Asn Phe Ile Tyr Ile  Ala Ala Thr 
    3560                 3565                 3570             


Tyr Thr  Phe Ser Gly Leu Gln  Glu Gly Thr Gly Arg  Pro Val Ala 
    3575                 3580                 3585             


Ser Asn  Lys Ala Ile Thr Cys  Ala Glu Leu Val Leu  Asp Val Ser 
    3590                 3595                 3600             


Pro Lys  Thr Gln Arg Val Ile  Leu Lys Lys Lys Glu  Pro Gly Lys 
    3605                 3610                 3615             


Arg Ser  Gln Leu Trp Arg Met  Thr Gly Thr Gly Met  Leu Ala His 
    3620                 3625                 3630             


Glu Gly  Ser Ser Val Pro His  Asn Pro Asn Lys Pro  Ser Ala Ala 
    3635                 3640                 3645             


Arg Ser  Thr Glu Gly Ser Ala  Ile Leu Asp Ile Ala  Gly Leu Ala 
    3650                 3655                 3660             


Ala Val  Thr Asp Asn Arg Tyr  Glu Pro Leu Met Leu  Arg Lys Pro 
    3665                 3670                 3675             


Asp Arg  Arg Arg Ser Thr Thr  Gln Thr Trp Ser Phe  Arg Glu Gly 
    3680                 3685                 3690             


Lys Leu  Thr Cys Gly Leu His  Gly Leu Val Val Gln  Ala Lys Gly 
    3695                 3700                 3705             


Gly Leu  Ser Gly Leu Phe Asp  Gly Ala Glu Val Val  Leu Gly Pro 
    3710                 3715                 3720             


Asp Thr  Ser Met Glu Leu Leu  Gly Pro Val Pro Pro  Glu Gln Gln 
    3725                 3730                 3735             


Phe Ile  Asn Gln Lys Met Arg  Pro Gly Ser Gly Met  Leu Ser Ile 
    3740                 3745                 3750             


Arg Val  Ile Pro Asp Gly Pro  Thr Arg Ala Leu Gln  Ile Thr Asp 
    3755                 3760                 3765             


Phe Cys  His Arg Lys Ser Ser  Arg Ser Tyr Glu Val  Asp Glu Leu 
    3770                 3775                 3780             


Pro Val  Thr Glu Gln Glu Leu  Gln Lys Leu Lys Asn  Pro Asp Thr 
    3785                 3790                 3795             


Glu Gln  Glu Leu Glu Val Leu  Val Arg Leu Glu Gly  Gly Ile Gly 
    3800                 3805                 3810             


Leu Ser  Leu Ile Asn Lys Val  Pro Glu Glu Leu Val  Phe Ala Ser 
    3815                 3820                 3825             


Leu Thr  Gly Ile Asn Val His  Tyr Thr Gln Leu Ala  Thr Ser His 
    3830                 3835                 3840             


Met Leu  Glu Leu Ser Ile Gln  Asp Val Gln Val Asp  Asn Gln Leu 
    3845                 3850                 3855             


Ile Gly  Thr Thr Gln Pro Phe  Met Leu Tyr Val Thr  Pro Leu Ser 
    3860                 3865                 3870             


Asn Glu  Asn Glu Val Ile Glu  Thr Gly Pro Ala Val  Gln Val Asn 
    3875                 3880                 3885             


Ala Val  Lys Phe Pro Ser Lys  Ser Ala Leu Thr Asn  Ile Tyr Lys 
    3890                 3895                 3900             


His Leu  Met Ile Thr Ala Gln  Arg Phe Thr Val Gln  Ile Glu Glu 
    3905                 3910                 3915             


Lys Leu  Leu Leu Lys Leu Leu  Ser Phe Phe Gly Tyr  Asp Gln Ala 
    3920                 3925                 3930             


Glu Ser  Glu Val Glu Lys Tyr  Asp Glu Asn Leu His  Glu Lys Thr 
    3935                 3940                 3945             


Ala Glu  Gln Gly Gly Thr Pro  Ile Arg Tyr Tyr Phe  Glu Asn Leu 
    3950                 3955                 3960             


Lys Ile  Ser Ile Pro Gln Ile  Lys Leu Ser Val Phe  Thr Ser Asn 
    3965                 3970                 3975             


Lys Leu  Pro Leu Asp Leu Lys  Ala Leu Lys Ser Thr  Leu Gly Phe 
    3980                 3985                 3990             


Pro Leu  Ile Arg Phe Glu Asp  Ala Val Ile Asn Leu  Asp Pro Phe 
    3995                 4000                 4005             


Thr Arg  Val His Pro Tyr Glu  Thr Lys Glu Phe Ile  Ile Asn Asp 
    4010                 4015                 4020             


Ile Leu  Lys His Phe Gln Glu  Glu Leu Leu Ser Gln  Ala Ala Arg 
    4025                 4030                 4035             


Ile Leu  Gly Ser Val Asp Phe  Leu Gly Asn Pro Met  Gly Leu Leu 
    4040                 4045                 4050             


Asn Asp  Val Ser Glu Gly Val  Thr Gly Leu Ile Lys  Tyr Gly Asn 
    4055                 4060                 4065             


Val Gly  Gly Leu Ile Arg Asn  Val Thr His Gly Val  Ser Asn Ser 
    4070                 4075                 4080             


Ala Ala  Lys Phe Ala Gly Thr  Leu Ser Asp Gly Leu  Gly Lys Thr 
    4085                 4090                 4095             


Met Asp  Asn Arg His Gln Ser  Glu Arg Glu Tyr Ile  Arg Tyr His 
    4100                 4105                 4110             


Ala Ala  Thr Ser Gly Glu His  Leu Val Ala Gly Ile  His Gly Leu 
    4115                 4120                 4125             


Ala His  Gly Ile Ile Gly Gly  Leu Thr Ser Val Ile  Thr Ser Thr 
    4130                 4135                 4140             


Val Glu  Gly Val Lys Thr Glu  Gly Gly Val Ser Gly  Phe Ile Ser 
    4145                 4150                 4155             


Gly Leu  Gly Lys Gly Leu Val  Gly Thr Val Thr Lys  Pro Val Ala 
    4160                 4165                 4170             


Gly Ala  Leu Asp Phe Ala Ser  Glu Thr Ala Gln Ala  Val Arg Asp 
    4175                 4180                 4185             


Thr Ala  Thr Leu Ser Gly Pro  Arg Thr Gln Ala Gln  Arg Val Arg 
    4190                 4195                 4200             


Lys Pro  Arg Cys Cys Thr Gly  Pro Gln Gly Leu Leu  Pro Arg Tyr 
    4205                 4210                 4215             


Ser Glu  Ser Gln Ala Glu Gly  Gln Glu Gln Leu Phe  Lys Leu Thr 
    4220                 4225                 4230             


Asp Asn  Ile Gln Asp Glu Phe  Phe Ile Ala Val Glu  Asn Ile Asp 
    4235                 4240                 4245             


Ser Tyr  Cys Val Leu Ile Ser  Ser Lys Ala Val Tyr  Phe Leu Lys 
    4250                 4255                 4260             


Ser Gly  Asp Tyr Val Asp Arg  Glu Ala Ile Phe Leu  Glu Val Lys 
    4265                 4270                 4275             


Tyr Asp  Asp Leu Tyr His Cys  Leu Val Ser Lys Asp  His Gly Lys 
    4280                 4285                 4290             


Val Tyr  Val Gln Val Thr Lys  Lys Ala Val Ser Thr  Ser Ser Gly 
    4295                 4300                 4305             


Val Ser  Ile Pro Gly Pro Ser  His Gln Lys Pro Met  Val His Val 
    4310                 4315                 4320             


Lys Ser  Glu Val Leu Ala Val  Lys Leu Ser Gln Glu  Ile Asn Tyr 
    4325                 4330                 4335             


Ala Lys  Ser Leu Tyr Tyr Glu  Gln Gln Leu Met Leu  Arg Leu Ser 
    4340                 4345                 4350             


Glu Asn  Arg Glu Gln Leu Glu  Leu Asp Ser 
    4355                 4360             


<210>  5
<211>  5212
<212>  DNA
<213>  Homo Sapiens

<400>  5
actccccctg cctcctctcc gcctttaact tctcgggaag atgaggcagt ttggcatctg       60

tggccgagtt gctgttgccg ggtgatagtt ggagcggaga cttagcataa tggcagaacc      120

tgtttctcca ctgaagcact ttgtgctggc taagaaggcg attactgcaa tctttgacca      180

gttactggag tttgttactg aaggatcaca ttttgttgaa gcaacatata agaatccgga      240

acttgatcga atagccactg aagatgatct ggtagaaatg caaggatata aagacaagct      300

ttccatcatt ggtgaggtgc tatctcggag acacatgaag gtggcatttt ttggcaggac      360

aagcagtggg aagagctctg ttatcaatgc aatgttgtgg gataaagttc tccctagtgg      420

gattggccat ataaccaatt gcttcctaag tgttgaagga actgatggag ataaagccta      480

tcttatgaca gaaggatcag atgaaaaaaa gagtgtgaag acagttaatc aactggccca      540

tgcccttcac atggacaaag atttgaaagc tggctgtctt gtacgtgtgt tttggccaaa      600

agcaaaatgt gccctcttga gagatgacct ggtgttagta gacagtccag gcacagatgt      660

cactacagag ctggatagct ggattgataa gttttgccta gatgctgatg tctttgtttt      720

ggtcgcaaac tctgaatcaa cactaatgaa tacggaaaaa cacttttttc acaaggtgaa      780

tgagcggctt tccaagccta atattttcat tctcaataat cgttgggatg cctctgcatc      840

agagccagaa tatatggaag acgtacgcag acagcacatg gaaagatgcc tgcatttctt      900

ggtggaggag ctcaaagttg taaatgcttt agaagcacag aatcgtatct tctttgtttc      960

agcaaaggaa gttcttagtg ctagaaagca aaaagcacag gggatgccag aaagtggtgt     1020

ggcacttgct gaaggatttc atgcaagatt acaggaattt cagaattttg aacaaatctt     1080

tgaggagtgt atctcgcagt cagcagtgaa aacaaagttc gaacagcaca ctatcagagc     1140

taaacagata ctagctactg tgaaaaacat aatggattca gtaaacctgg cagctgaaga     1200

taaaaggcat tattcagtgg aagagaggga agaccaaatt gatagactgg actttattcg     1260

aaaccagatg aaccttttaa cactggatgt taagaaaaaa atcaaggagg ttaccgagga     1320

ggtggcaaac aaagtttcat gtgcaatgac agatgaaatt tgtcgactgt ctgttttggt     1380

tgatgaattt tgttcagagt ttcatcctaa tccagatgta ttaaaaatat ataaaagtga     1440

attaaataag cacatagagg atggtatggg aagaaatttg gctgatcgat gcaccgatga     1500

agtaaacgcc ttagtgcttc agacccagca agaaattatt gaaaatttga agccattact     1560

tccagctggt atacaggata aactacatac actgatccct tgcaagaaat ttgatctcag     1620

ttataatcta aattaccaca agttatgttc agattttcaa gaggatattg tatttcgttt     1680

ttccctgggc tggtcttccc ttgtacatcg atttttgggc cctagaaatg ctcaaagggt     1740

gctcctagga ttatcagagc ctatctttca gctccctaga tctttagctt ctactcccac     1800

tgctcctacc actccagcaa cgccagataa tgcatcacag gaagaactca tgattacatt     1860

agtaacagga ttggcgtccg ttacatctag aacttctatg ggcatcatta ttgttggagg     1920

agtgatttgg aaaactatag gctggaaact cctatctgtt tcattaacta tgtatggagc     1980

tttgtatctt tatgaaagac tgagctggac cacccatgcc aaggagcgag cctttaaaca     2040

gcagtttgta aactatgcaa ctgaaaaact gaggatgatt gttagctcca cgagtgcaaa     2100

ctgcagtcac caagtaaaac aacaaatagc taccactttt gctcgcctgt gccaacaagt     2160

tgatattact caaaaacagc tggaagaaga aattgctaga ttacccaaag aaatagatca     2220

gttggagaaa atacaaaaca attcaaagct cttaagaaat aaagctgttc aacttgaaaa     2280

tgagctggag aattttacta agcagtttct accttcaagc aatgaagaat cctaacaata     2340

gagattgctt tggtgaccat gataggagga aacgaaactt gtaagattgg aacagttgtt     2400

atttttatga aattacttta aatatgaatt gtactaactg tacctaaata gcaaagccct     2460

gtgtagattc tggtaatgat ctgtctcagg gtatgtgtat ttttgaagag tgttatgtcc     2520

ttagttttaa ttttgagtaa agaaaaggct aaaatcatga attagttaca agcaacagta     2580

ccaacttatg tgacccctga ggggtggggc tgtgagctct taatttgttt ttgattctga     2640

aaaactctgc ttcctggcat ccaggagtta gagattgagc ctttcatctt ctttctcaaa     2700

actagttttt gatgctttct ttcatgggaa tagtcacttt tttatttagt aaatcgcatt     2760

gctggaacca ccaaggagtg tggaatgtcc ttgagtgtat tatttatgca agtcacagtc     2820

acgttgccat catggcagct atgtgaaaca ctaataaatg tgtttttact ttttattccc     2880

gttaaaactg atgtaaaaca ggataaaggc ttgttatagt cacttataag tatctgggtc     2940

taagtaattt ccttagatgt ttctaaagaa acattttcag ctttgctccc attatgattc     3000

caataaggaa cgctttccta gtgcaatttt aggagtaaag tttgaagaga taaaaatagc     3060

caaagatagg agacgtctga attttgaatg ataaacagtg atgttttaaa aaagctgttg     3120

ttcttcagga ggcatttgcc taggatattg ctggattata ccccattgga ggcttttaat     3180

tttatttgta tgaattttcc aggatttcat taaaaattat tattgtattt tttaccttaa     3240

tgaaagattt tgggttcaaa tatctttcta tattaaaagc tgattgagtc tgtacatatg     3300

taaattatgc ctagtggagg ttctgttgac tttcttcccc actgtggaag aggccagttt     3360

tgcctccatt tgcacattca tttcagttat ttctgatcca taaatataac atttacaaaa     3420

ttcttccttg agctggtgga aatgcctcac cagtttcctc tttaatgaat caaataaaat     3480

ctttaactga tgttaaaaaa aattgattga aactcagatg gaatggaaat gtacaaaaat     3540

gacaccattc taggaatttg ctagacaaaa tgtaggacta ccagatcagt atctcctaga     3600

cacttgttag aaatgcacaa tcccggggaa cgcagtacat ttggccacat gtagtttatg     3660

tttccttttc atgggaggga taaaatttaa agcttttttt ttctttgaat acagtccttc     3720

cttttctatg ccttttaagg cttctagatg ctattcagcc tttttacagc aggtgcaact     3780

ctatttttca aggtatctta gaagataaca ctaggccatt gaagcctttc aaaaatatat     3840

ttttatgcaa attgacacga gtgcagtata ctaatgcaaa ttaattttgg tgtttagctt     3900

ttattgctca tttataaccc aagaaatggt acagaccaca gtaagtggga ttaggtaaca     3960

actacaacat ggaaaaacag tgtctaagat cacgtactgc taatttaggt tacaaaactc     4020

aaggctgtaa cctttatatg aaagtactta agcttgaaag ttcataatag tttggtatca     4080

cctcattagt atagtacagt ggttctcaaa gtttggtcct gggtcatcga cattacttct     4140

ttttctttct gagacagggt ctcagtctgt cacccaggat ggagtgcagt ggcgtgatca     4200

tggctcactg cagcctcaac ctctcgggtt caggtgatcc tcccacatca gcctcctggg     4260

tggctgggac tacaggcaca cgccaccatg cctggctagt ttttgtaaag acgaggtttc     4320

cccatgttgt gcaggctggt cttgaactca cagactcaag tgatcctttt acctcagcct     4380

cccaaactgt tgggataaca ggtgtaagcc accacacaca gctataatca accttcaaac     4440

ttataaaaag tgtggatcct tgggtctgaa cccagaccta tggagtcaga cagtaggttt     4500

gaggcccagc aatctatggt ttaacaagcc atccaggtgt ttctgatgca cagtgaaatt     4560

ggggtaccac tggtattagg tttggtatgg caactttttc atcacttgtt ttatgtagtt     4620

gtctgatcaa ttgtgaaaac ataatgaatg ttggaaatgg aacagtaaaa taacgaaagc     4680

caactttttt tttttttttt tttttttttg agacggagtc tcgctctgtc gcccaggctg     4740

gagtgcagtg gcgcgatctc ggctcactgc aagctccgcc tcccgggttc acgccattct     4800

cctgcctcag cctcccgagt agctgggact acaggcgccc gccaccacgc ccggctaatt     4860

ttttgtattt ttagtagaga cggggtttca ccgtgttagc caggatggtc tcgatctcct     4920

gacctcgtga tccacccgcc tcggcctccc aaagtgctgg gattacaggc gtgagccacc     4980

gcgcccggcc gaaagccaac tcttatgcct agaaatatgt gcacctatga ccaagcccat     5040

gaattataca ggaattatgt aattatgagt gatgtacttc aaagttattg cacatacact     5100

tgtttacttt gtatgtttgc aggattaaac tttgtataat ctttttacaa aaattttttt     5160

tcagtatgca agcttgcaag atgaaaataa aacctgtttg cctgatagtt ga             5212


<210>  6
<211>  741
<212>  PRT
<213>  Homo Sapiens

<400>  6

Met Ala Glu Pro Val Ser Pro Leu Lys His Phe Val Leu Ala Lys Lys 
1               5                   10                  15      


Ala Ile Thr Ala Ile Phe Asp Gln Leu Leu Glu Phe Val Thr Glu Gly 
            20                  25                  30          


Ser His Phe Val Glu Ala Thr Tyr Lys Asn Pro Glu Leu Asp Arg Ile 
        35                  40                  45              


Ala Thr Glu Asp Asp Leu Val Glu Met Gln Gly Tyr Lys Asp Lys Leu 
    50                  55                  60                  


Ser Ile Ile Gly Glu Val Leu Ser Arg Arg His Met Lys Val Ala Phe 
65                  70                  75                  80  


Phe Gly Arg Thr Ser Ser Gly Lys Ser Ser Val Ile Asn Ala Met Leu 
                85                  90                  95      


Trp Asp Lys Val Leu Pro Ser Gly Ile Gly His Ile Thr Asn Cys Phe 
            100                 105                 110         


Leu Ser Val Glu Gly Thr Asp Gly Asp Lys Ala Tyr Leu Met Thr Glu 
        115                 120                 125             


Gly Ser Asp Glu Lys Lys Ser Val Lys Thr Val Asn Gln Leu Ala His 
    130                 135                 140                 


Ala Leu His Met Asp Lys Asp Leu Lys Ala Gly Cys Leu Val Arg Val 
145                 150                 155                 160 


Phe Trp Pro Lys Ala Lys Cys Ala Leu Leu Arg Asp Asp Leu Val Leu 
                165                 170                 175     


Val Asp Ser Pro Gly Thr Asp Val Thr Thr Glu Leu Asp Ser Trp Ile 
            180                 185                 190         


Asp Lys Phe Cys Leu Asp Ala Asp Val Phe Val Leu Val Ala Asn Ser 
        195                 200                 205             


Glu Ser Thr Leu Met Asn Thr Glu Lys His Phe Phe His Lys Val Asn 
    210                 215                 220                 


Glu Arg Leu Ser Lys Pro Asn Ile Phe Ile Leu Asn Asn Arg Trp Asp 
225                 230                 235                 240 


Ala Ser Ala Ser Glu Pro Glu Tyr Met Glu Asp Val Arg Arg Gln His 
                245                 250                 255     


Met Glu Arg Cys Leu His Phe Leu Val Glu Glu Leu Lys Val Val Asn 
            260                 265                 270         


Ala Leu Glu Ala Gln Asn Arg Ile Phe Phe Val Ser Ala Lys Glu Val 
        275                 280                 285             


Leu Ser Ala Arg Lys Gln Lys Ala Gln Gly Met Pro Glu Ser Gly Val 
    290                 295                 300                 


Ala Leu Ala Glu Gly Phe His Ala Arg Leu Gln Glu Phe Gln Asn Phe 
305                 310                 315                 320 


Glu Gln Ile Phe Glu Glu Cys Ile Ser Gln Ser Ala Val Lys Thr Lys 
                325                 330                 335     


Phe Glu Gln His Thr Ile Arg Ala Lys Gln Ile Leu Ala Thr Val Lys 
            340                 345                 350         


Asn Ile Met Asp Ser Val Asn Leu Ala Ala Glu Asp Lys Arg His Tyr 
        355                 360                 365             


Ser Val Glu Glu Arg Glu Asp Gln Ile Asp Arg Leu Asp Phe Ile Arg 
    370                 375                 380                 


Asn Gln Met Asn Leu Leu Thr Leu Asp Val Lys Lys Lys Ile Lys Glu 
385                 390                 395                 400 


Val Thr Glu Glu Val Ala Asn Lys Val Ser Cys Ala Met Thr Asp Glu 
                405                 410                 415     


Ile Cys Arg Leu Ser Val Leu Val Asp Glu Phe Cys Ser Glu Phe His 
            420                 425                 430         


Pro Asn Pro Asp Val Leu Lys Ile Tyr Lys Ser Glu Leu Asn Lys His 
        435                 440                 445             


Ile Glu Asp Gly Met Gly Arg Asn Leu Ala Asp Arg Cys Thr Asp Glu 
    450                 455                 460                 


Val Asn Ala Leu Val Leu Gln Thr Gln Gln Glu Ile Ile Glu Asn Leu 
465                 470                 475                 480 


Lys Pro Leu Leu Pro Ala Gly Ile Gln Asp Lys Leu His Thr Leu Ile 
                485                 490                 495     


Pro Cys Lys Lys Phe Asp Leu Ser Tyr Asn Leu Asn Tyr His Lys Leu 
            500                 505                 510         


Cys Ser Asp Phe Gln Glu Asp Ile Val Phe Arg Phe Ser Leu Gly Trp 
        515                 520                 525             


Ser Ser Leu Val His Arg Phe Leu Gly Pro Arg Asn Ala Gln Arg Val 
    530                 535                 540                 


Leu Leu Gly Leu Ser Glu Pro Ile Phe Gln Leu Pro Arg Ser Leu Ala 
545                 550                 555                 560 


Ser Thr Pro Thr Ala Pro Thr Thr Pro Ala Thr Pro Asp Asn Ala Ser 
                565                 570                 575     


Gln Glu Glu Leu Met Ile Thr Leu Val Thr Gly Leu Ala Ser Val Thr 
            580                 585                 590         


Ser Arg Thr Ser Met Gly Ile Ile Ile Val Gly Gly Val Ile Trp Lys 
        595                 600                 605             


Thr Ile Gly Trp Lys Leu Leu Ser Val Ser Leu Thr Met Tyr Gly Ala 
    610                 615                 620                 


Leu Tyr Leu Tyr Glu Arg Leu Ser Trp Thr Thr His Ala Lys Glu Arg 
625                 630                 635                 640 


Ala Phe Lys Gln Gln Phe Val Asn Tyr Ala Thr Glu Lys Leu Arg Met 
                645                 650                 655     


Ile Val Ser Ser Thr Ser Ala Asn Cys Ser His Gln Val Lys Gln Gln 
            660                 665                 670         


Ile Ala Thr Thr Phe Ala Arg Leu Cys Gln Gln Val Asp Ile Thr Gln 
        675                 680                 685             


Lys Gln Leu Glu Glu Glu Ile Ala Arg Leu Pro Lys Glu Ile Asp Gln 
    690                 695                 700                 


Leu Glu Lys Ile Gln Asn Asn Ser Lys Leu Leu Arg Asn Lys Ala Val 
705                 710                 715                 720 


Gln Leu Glu Asn Glu Leu Glu Asn Phe Thr Lys Gln Phe Leu Pro Ser 
                725                 730                 735     


Ser Asn Glu Glu Ser 
            740     


<210>  7
<211>  4262
<212>  DNA
<213>  Homo Sapiens

<400>  7
gtagtgagtg tgatggccgc cgcgaggccg ggaaggtgaa gcgcaatgtc cctgctcttc       60

tctcgatgca actctatcgt cacagtcaag aaaaataaga gacacatggc tgaggtgaat      120

gcatccccac ttaagcactt tgtcactgcc aagaagaaga tcaatggcat ttttgagcag      180

ctgggggcct acatccagga gagcgccacc ttccttgaag acacgtacag gaatgcagaa      240

ctggaccccg ttaccacaga agaacaggtt ctggacgtca aaggttacct atccaaagtg      300

agaggcatca gtgaggtgct ggctcggagg cacatgaaag tggctttttt tggccggacg      360

agcaatggga agagcaccgt gatcaatgcc atgctctggg acaaagttct gccctctggg      420

attggccaca ccaccaattg cttcctgcgg gtagagggca cagatggcca tgaggccttt      480

ctccttaccg agggctcaga ggaaaagagg agtgccaaga ctgtgaacca gctggcccat      540

gccctccacc aggacaagca gctccatgcc ggcagcctag tgagtgtgat gtggcccaac      600

tctaagtgcc cacttctgaa ggatgacctc gttttgatgg acagccctgg tattgatgtc      660

accacagagc tggacagctg gattgacaag ttttgtctgg atgctgatgt gtttgtgctg      720

gtggccaact cagagtccac cctgatgcag acggaaaagc acttcttcca caaggtgagt      780

gagcgtctct cccggccaaa catcttcatc ctgaacaacc gctgggatgc atctgcctca      840

gagcccgagt acatggagga ggtgcggcgg cagcacatgg agcgttgtac cagcttcctg      900

gtggatgagc tgggcgtggt ggatcgatcc caggccgggg accgcatctt ctttgtgtct      960

gctaaggagg tgctcaacgc caggattcag aaagcccagg gcatgcctga aggagggggc     1020

gctctcgcag aaggctttca agtgaggatg tttgagtttc agaattttga gaggagattt     1080

gaggagtgca tctcccagtc tgcagtgaag accaagtttg agcagcacac ggtccgggcc     1140

aagcagattg cagaggcggt tcgactcatc atggactccc tgcacatggc ggctcgggag     1200

cagcaggttt actgcgagga aatgcgtgaa gagcggcaag accgactgaa atttattgac     1260

aaacagctgg agctcttggc tcaagactat aagctgcgaa ttaagcagat tacggaggaa     1320

gtggagaggc aggtgtcgac tgcaatggcc gaggagatca ggcgcctctc tgtactggtg     1380

gacgattacc agatggactt ccacccttct ccagtagtcc tcaaggttta taagaatgag     1440

ctgcaccgcc acatagagga aggactgggt cgaaacatgt ctgaccgctg ctccacggcc     1500

atcaccaact ccctgcagac catgcagcag gacatgatag atggcttgaa acccctcctt     1560

cctgtgtctg tgcggagtca gatagacatg ctggtcccac gccagtgctt ctccctcaac     1620

tatgacctaa actgtgacaa gctgtgtgct gacttccagg aagacattga gttccatttc     1680

tctctcggat ggaccatgct ggtgaatagg ttcctgggcc ccaagaacag ccgtcgggcc     1740

ttgatgggct acaatgacca ggtccagcgt cccatccctc tgacgccagc caaccccagc     1800

atgcccccac tgccacaggg ctcgctcacc caggaggagt tcatggtttc catggttacc     1860

ggcctggcct ccttgacatc caggacctcc atgggcattc ttgttgttgg aggagtggtg     1920

tggaaggcag tgggctggcg gctcattgcc ctctcctttg ggctctatgg cctcctctac     1980

gtctatgagc gtctgacctg gaccaccaag gccaaggaga gggccttcaa gcgccagttt     2040

gtggagcatg ccagcgagaa gctgcagctt gtcatcagct acactggctc caactgcagc     2100

caccaagtcc agcaggaact gtctgggacc tttgctcatc tgtgtcagca agttgacgtc     2160

acccgggaga acctggagca ggaaattgcc gccatgaaca agaaaattga ggttcttgac     2220

tcacttcaga gcaaagcaaa gctgctcagg aataaagccg gttggttgga cagtgagctc     2280

aacatgttca cacaccagta cctgcagccc agcagatagt gggcacctga ggcggagtct     2340

gcgtggagag gggcggtgct gccagcccta agtgccatgt gggctccccc aggggcacgt     2400

gtggctcctg ccccctggcc actgccaaga gaatgaagca cccagtctcg taccattttg     2460

agccctccag cactacttat tttcccccac ctttgcctgc tgttgctgga agagctggct     2520

cataccccca aaggacactt tcagcgacag ctatggacag catggtacca aggagttaag     2580

ttgaggcttt ttccagcttt ctctggttca tttgattgct tgataaggcc tcaggatctc     2640

agcattgcac aatgcctcat ggaagccttt gagggtatca cacagacacc cccaccttcc     2700

tccagcctgt gcgcacctgc cctccttgca gcccagcaca cctgcaggtg taagggacga     2760

ttggagtttc ttcccagaga gtctgtccca gaaggactgt ggcttgtgtg tgtccatctc     2820

gcctgttggc tcagtgcttc atcccatttg cagagcctca gacacgtctt ggtggtgagg     2880

ctcagttacc cctgggctta ggctgaggcg ggccctgtgc tgggggtggt agaaaggatg     2940

ctgctgaggc agctggagga gtgggagtag ctcagagggg agggctgttg gatgtatggg     3000

gagctggcag agcaggtggc agtcactggg acaaggaggg acttgcctct cttctcatta     3060

ttgtgtcctt tgctttagtg tcagtcctgg acttgtgcag gcctgttttg tgtagatctg     3120

ttttggaaga tggcatggtc taggtggttg aaggatgtag tagaaggatg gatggtggaa     3180

ggtggggacg ttggtggctg gctgaggtgc atgggcccca cacaggacag ctggagaatg     3240

ggccgtccac ttggcctcgt tctgcgaggg gctcatgggt ctgagagccc ccacccacta     3300

ggcttgattg catccctgtt gtgcccttta agagacatgt ttccacccca cccccaacct     3360

tgtcccaagt gccctggact aaatttcctg tgccagtgac tgcagttggc caagggacaa     3420

tgtggaaaac ccagtgtcca tctttccacc ctccctgatc tccagaacct tcgactgacc     3480

cccttgtctt tatgctgatg ttgagttttg ggattgttac tggttgaagt gggggcagat     3540

gcctgtcacc aaggtgttga ctgtgtgaga aaagcagttt gggtgacaaa tcctgtgtgg     3600

cacaagttgg atcgcttcct agaaataagc aacacctctc ccaaaaagca gcccacaagg     3660

caggggccca gcagcccagc catcactcat ctttgaggaa atgagttggt agcctctgtg     3720

cactgtttgg tggccacatc acaggtgatg tcctgttcac atacctgctt gtatttaaag     3780

ccctcagtct gtcctgttgt gtggggcgaa gtgatggact ctgccaggtg gacatgctgt     3840

gggtggatgt tcccggcgtg tgccgggcct gaatggacag gggccacttc acagcatgtc     3900

agggaaaatc actgtcacac aattccaatg gattttgtgc tctttttgaa aaaaaaaaat     3960

tctttagcgt aaacatgaat tttttttcaa tgtagcccct ggggaatgaa tgaaattttg     4020

agcttcttca atacgtaaaa ttaaatttat accactgagg gagagaccct ttctgaaaga     4080

agtatggcca aaagcacttt aatgctgctg acattgttgt ttttatgttc atttgctgga     4140

gcgcaagacg tgctgacaca gtgagttttc tctgatgtat ttaaggtgat gtatttgctt     4200

gagttactcc tgtatcattg ctcataatat tggaaactaa aataaaacct agttggaaat     4260

cc                                                                    4262


<210>  8
<211>  4407
<212>  DNA
<213>  Homo Sapiens

<400>  8
gtagtgagtg tgatggccgc cgcgaggccg ggaaggtgaa gtcaggactg gtggagtcaa       60

cacagtcaat caatagccaa cctcaacctg agacaggaca gaagagaact cagaatcttt      120

ttgtcttttg gacttcagcc atgtccatga tgcctaccct gtgaagatct ctcaccatcc      180

aaaaaacgca atgtccctgc tcttctctcg atgcaactct atcgtcacag tcaagaaaaa      240

taagagacac atggctgagg tgaatgcatc cccacttaag cactttgtca ctgccaagaa      300

gaagatcaat ggcatttttg agcagctggg ggcctacatc caggagagcg ccaccttcct      360

tgaagacacg tacaggaatg cagaactgga ccccgttacc acagaagaac aggttctgga      420

cgtcaaaggt tacctatcca aagtgagagg catcagtgag gtgctggctc ggaggcacat      480

gaaagtggct ttttttggcc ggacgagcaa tgggaagagc accgtgatca atgccatgct      540

ctgggacaaa gttctgccct ctgggattgg ccacaccacc aattgcttcc tgcgggtaga      600

gggcacagat ggccatgagg cctttctcct taccgagggc tcagaggaaa agaggagtgc      660

caagactgtg aaccagctgg cccatgccct ccaccaggac aagcagctcc atgccggcag      720

cctagtgagt gtgatgtggc ccaactctaa gtgcccactt ctgaaggatg acctcgtttt      780

gatggacagc cctggtattg atgtcaccac agagctggac agctggattg acaagttttg      840

tctggatgct gatgtgtttg tgctggtggc caactcagag tccaccctga tgcagacgga      900

aaagcacttc ttccacaagg tgagtgagcg tctctcccgg ccaaacatct tcatcctgaa      960

caaccgctgg gatgcatctg cctcagagcc cgagtacatg gaggaggtgc ggcggcagca     1020

catggagcgt tgtaccagct tcctggtgga tgagctgggc gtggtggatc gatcccaggc     1080

cggggaccgc atcttctttg tgtctgctaa ggaggtgctc aacgccagga ttcagaaagc     1140

ccagggcatg cctgaaggag ggggcgctct cgcagaaggc tttcaagtga ggatgtttga     1200

gtttcagaat tttgagagga gatttgagga gtgcatctcc cagtctgcag tgaagaccaa     1260

gtttgagcag cacacggtcc gggccaagca gattgcagag gcggttcgac tcatcatgga     1320

ctccctgcac atggcggctc gggagcagca ggtttactgc gaggaaatgc gtgaagagcg     1380

gcaagaccga ctgaaattta ttgacaaaca gctggagctc ttggctcaag actataagct     1440

gcgaattaag cagattacgg aggaagtgga gaggcaggtg tcgactgcaa tggccgagga     1500

gatcaggcgc ctctctgtac tggtggacga ttaccagatg gacttccacc cttctccagt     1560

agtcctcaag gtttataaga atgagctgca ccgccacata gaggaaggac tgggtcgaaa     1620

catgtctgac cgctgctcca cggccatcac caactccctg cagaccatgc agcaggacat     1680

gatagatggc ttgaaacccc tccttcctgt gtctgtgcgg agtcagatag acatgctggt     1740

cccacgccag tgcttctccc tcaactatga cctaaactgt gacaagctgt gtgctgactt     1800

ccaggaagac attgagttcc atttctctct cggatggacc atgctggtga ataggttcct     1860

gggccccaag aacagccgtc gggccttgat gggctacaat gaccaggtcc agcgtcccat     1920

ccctctgacg ccagccaacc ccagcatgcc cccactgcca cagggctcgc tcacccagga     1980

ggagttcatg gtttccatgg ttaccggcct ggcctccttg acatccagga cctccatggg     2040

cattcttgtt gttggaggag tggtgtggaa ggcagtgggc tggcggctca ttgccctctc     2100

ctttgggctc tatggcctcc tctacgtcta tgagcgtctg acctggacca ccaaggccaa     2160

ggagagggcc ttcaagcgcc agtttgtgga gcatgccagc gagaagctgc agcttgtcat     2220

cagctacact ggctccaact gcagccacca agtccagcag gaactgtctg ggacctttgc     2280

tcatctgtgt cagcaagttg acgtcacccg ggagaacctg gagcaggaaa ttgccgccat     2340

gaacaagaaa attgaggttc ttgactcact tcagagcaaa gcaaagctgc tcaggaataa     2400

agccggttgg ttggacagtg agctcaacat gttcacacac cagtacctgc agcccagcag     2460

atagtgggca cctgaggcgg agtctgcgtg gagaggggcg gtgctgccag ccctaagtgc     2520

catgtgggct cccccagggg cacgtgtggc tcctgccccc tggccactgc caagagaatg     2580

aagcacccag tctcgtacca ttttgagccc tccagcacta cttattttcc cccacctttg     2640

cctgctgttg ctggaagagc tggctcatac ccccaaagga cactttcagc gacagctatg     2700

gacagcatgg taccaaggag ttaagttgag gctttttcca gctttctctg gttcatttga     2760

ttgcttgata aggcctcagg atctcagcat tgcacaatgc ctcatggaag cctttgaggg     2820

tatcacacag acacccccac cttcctccag cctgtgcgca cctgccctcc ttgcagccca     2880

gcacacctgc aggtgtaagg gacgattgga gtttcttccc agagagtctg tcccagaagg     2940

actgtggctt gtgtgtgtcc atctcgcctg ttggctcagt gcttcatccc atttgcagag     3000

cctcagacac gtcttggtgg tgaggctcag ttacccctgg gcttaggctg aggcgggccc     3060

tgtgctgggg gtggtagaaa ggatgctgct gaggcagctg gaggagtggg agtagctcag     3120

aggggagggc tgttggatgt atggggagct ggcagagcag gtggcagtca ctgggacaag     3180

gagggacttg cctctcttct cattattgtg tcctttgctt tagtgtcagt cctggacttg     3240

tgcaggcctg ttttgtgtag atctgttttg gaagatggca tggtctaggt ggttgaagga     3300

tgtagtagaa ggatggatgg tggaaggtgg ggacgttggt ggctggctga ggtgcatggg     3360

ccccacacag gacagctgga gaatgggccg tccacttggc ctcgttctgc gaggggctca     3420

tgggtctgag agcccccacc cactaggctt gattgcatcc ctgttgtgcc ctttaagaga     3480

catgtttcca ccccaccccc aaccttgtcc caagtgccct ggactaaatt tcctgtgcca     3540

gtgactgcag ttggccaagg gacaatgtgg aaaacccagt gtccatcttt ccaccctccc     3600

tgatctccag aaccttcgac tgaccccctt gtctttatgc tgatgttgag ttttgggatt     3660

gttactggtt gaagtggggg cagatgcctg tcaccaaggt gttgactgtg tgagaaaagc     3720

agtttgggtg acaaatcctg tgtggcacaa gttggatcgc ttcctagaaa taagcaacac     3780

ctctcccaaa aagcagccca caaggcaggg gcccagcagc ccagccatca ctcatctttg     3840

aggaaatgag ttggtagcct ctgtgcactg tttggtggcc acatcacagg tgatgtcctg     3900

ttcacatacc tgcttgtatt taaagccctc agtctgtcct gttgtgtggg gcgaagtgat     3960

ggactctgcc aggtggacat gctgtgggtg gatgttcccg gcgtgtgccg ggcctgaatg     4020

gacaggggcc acttcacagc atgtcaggga aaatcactgt cacacaattc caatggattt     4080

tgtgctcttt ttgaaaaaaa aaaattcttt agcgtaaaca tgaatttttt ttcaatgtag     4140

cccctgggga atgaatgaaa ttttgagctt cttcaatacg taaaattaaa tttataccac     4200

tgagggagag accctttctg aaagaagtat ggccaaaagc actttaatgc tgctgacatt     4260

gttgttttta tgttcatttg ctggagcgca agacgtgctg acacagtgag ttttctctga     4320

tgtatttaag gtgatgtatt tgcttgagtt actcctgtat cattgctcat aatattggaa     4380

actaaaataa aacctagttg gaaatcc                                         4407


<210>  9
<211>  757
<212>  PRT
<213>  Homo Sapiens

<400>  9

Met Ser Leu Leu Phe Ser Arg Cys Asn Ser Ile Val Thr Val Lys Lys 
1               5                   10                  15      


Asn Lys Arg His Met Ala Glu Val Asn Ala Ser Pro Leu Lys His Phe 
            20                  25                  30          


Val Thr Ala Lys Lys Lys Ile Asn Gly Ile Phe Glu Gln Leu Gly Ala 
        35                  40                  45              


Tyr Ile Gln Glu Ser Ala Thr Phe Leu Glu Asp Thr Tyr Arg Asn Ala 
    50                  55                  60                  


Glu Leu Asp Pro Val Thr Thr Glu Glu Gln Val Leu Asp Val Lys Gly 
65                  70                  75                  80  


Tyr Leu Ser Lys Val Arg Gly Ile Ser Glu Val Leu Ala Arg Arg His 
                85                  90                  95      


Met Lys Val Ala Phe Phe Gly Arg Thr Ser Asn Gly Lys Ser Thr Val 
            100                 105                 110         


Ile Asn Ala Met Leu Trp Asp Lys Val Leu Pro Ser Gly Ile Gly His 
        115                 120                 125             


Thr Thr Asn Cys Phe Leu Arg Val Glu Gly Thr Asp Gly His Glu Ala 
    130                 135                 140                 


Phe Leu Leu Thr Glu Gly Ser Glu Glu Lys Arg Ser Ala Lys Thr Val 
145                 150                 155                 160 


Asn Gln Leu Ala His Ala Leu His Gln Asp Lys Gln Leu His Ala Gly 
                165                 170                 175     


Ser Leu Val Ser Val Met Trp Pro Asn Ser Lys Cys Pro Leu Leu Lys 
            180                 185                 190         


Asp Asp Leu Val Leu Met Asp Ser Pro Gly Ile Asp Val Thr Thr Glu 
        195                 200                 205             


Leu Asp Ser Trp Ile Asp Lys Phe Cys Leu Asp Ala Asp Val Phe Val 
    210                 215                 220                 


Leu Val Ala Asn Ser Glu Ser Thr Leu Met Gln Thr Glu Lys His Phe 
225                 230                 235                 240 


Phe His Lys Val Ser Glu Arg Leu Ser Arg Pro Asn Ile Phe Ile Leu 
                245                 250                 255     


Asn Asn Arg Trp Asp Ala Ser Ala Ser Glu Pro Glu Tyr Met Glu Glu 
            260                 265                 270         


Val Arg Arg Gln His Met Glu Arg Cys Thr Ser Phe Leu Val Asp Glu 
        275                 280                 285             


Leu Gly Val Val Asp Arg Ser Gln Ala Gly Asp Arg Ile Phe Phe Val 
    290                 295                 300                 


Ser Ala Lys Glu Val Leu Asn Ala Arg Ile Gln Lys Ala Gln Gly Met 
305                 310                 315                 320 


Pro Glu Gly Gly Gly Ala Leu Ala Glu Gly Phe Gln Val Arg Met Phe 
                325                 330                 335     


Glu Phe Gln Asn Phe Glu Arg Arg Phe Glu Glu Cys Ile Ser Gln Ser 
            340                 345                 350         


Ala Val Lys Thr Lys Phe Glu Gln His Thr Val Arg Ala Lys Gln Ile 
        355                 360                 365             


Ala Glu Ala Val Arg Leu Ile Met Asp Ser Leu His Met Ala Ala Arg 
    370                 375                 380                 


Glu Gln Gln Val Tyr Cys Glu Glu Met Arg Glu Glu Arg Gln Asp Arg 
385                 390                 395                 400 


Leu Lys Phe Ile Asp Lys Gln Leu Glu Leu Leu Ala Gln Asp Tyr Lys 
                405                 410                 415     


Leu Arg Ile Lys Gln Ile Thr Glu Glu Val Glu Arg Gln Val Ser Thr 
            420                 425                 430         


Ala Met Ala Glu Glu Ile Arg Arg Leu Ser Val Leu Val Asp Asp Tyr 
        435                 440                 445             


Gln Met Asp Phe His Pro Ser Pro Val Val Leu Lys Val Tyr Lys Asn 
    450                 455                 460                 


Glu Leu His Arg His Ile Glu Glu Gly Leu Gly Arg Asn Met Ser Asp 
465                 470                 475                 480 


Arg Cys Ser Thr Ala Ile Thr Asn Ser Leu Gln Thr Met Gln Gln Asp 
                485                 490                 495     


Met Ile Asp Gly Leu Lys Pro Leu Leu Pro Val Ser Val Arg Ser Gln 
            500                 505                 510         


Ile Asp Met Leu Val Pro Arg Gln Cys Phe Ser Leu Asn Tyr Asp Leu 
        515                 520                 525             


Asn Cys Asp Lys Leu Cys Ala Asp Phe Gln Glu Asp Ile Glu Phe His 
    530                 535                 540                 


Phe Ser Leu Gly Trp Thr Met Leu Val Asn Arg Phe Leu Gly Pro Lys 
545                 550                 555                 560 


Asn Ser Arg Arg Ala Leu Met Gly Tyr Asn Asp Gln Val Gln Arg Pro 
                565                 570                 575     


Ile Pro Leu Thr Pro Ala Asn Pro Ser Met Pro Pro Leu Pro Gln Gly 
            580                 585                 590         


Ser Leu Thr Gln Glu Glu Phe Met Val Ser Met Val Thr Gly Leu Ala 
        595                 600                 605             


Ser Leu Thr Ser Arg Thr Ser Met Gly Ile Leu Val Val Gly Gly Val 
    610                 615                 620                 


Val Trp Lys Ala Val Gly Trp Arg Leu Ile Ala Leu Ser Phe Gly Leu 
625                 630                 635                 640 


Tyr Gly Leu Leu Tyr Val Tyr Glu Arg Leu Thr Trp Thr Thr Lys Ala 
                645                 650                 655     


Lys Glu Arg Ala Phe Lys Arg Gln Phe Val Glu His Ala Ser Glu Lys 
            660                 665                 670         


Leu Gln Leu Val Ile Ser Tyr Thr Gly Ser Asn Cys Ser His Gln Val 
        675                 680                 685             


Gln Gln Glu Leu Ser Gly Thr Phe Ala His Leu Cys Gln Gln Val Asp 
    690                 695                 700                 


Val Thr Arg Glu Asn Leu Glu Gln Glu Ile Ala Ala Met Asn Lys Lys 
705                 710                 715                 720 


Ile Glu Val Leu Asp Ser Leu Gln Ser Lys Ala Lys Leu Leu Arg Asn 
                725                 730                 735     


Lys Ala Gly Trp Leu Asp Ser Glu Leu Asn Met Phe Thr His Gln Tyr 
            740                 745                 750         


Leu Gln Pro Ser Arg 
        755         


<210>  10
<211>  757
<212>  PRT
<213>  Homo Sapiens

<400>  10

Met Ser Leu Leu Phe Ser Arg Cys Asn Ser Ile Val Thr Val Lys Lys 
1               5                   10                  15      


Asn Lys Arg His Met Ala Glu Val Asn Ala Ser Pro Leu Lys His Phe 
            20                  25                  30          


Val Thr Ala Lys Lys Lys Ile Asn Gly Ile Phe Glu Gln Leu Gly Ala 
        35                  40                  45              


Tyr Ile Gln Glu Ser Ala Thr Phe Leu Glu Asp Thr Tyr Arg Asn Ala 
    50                  55                  60                  


Glu Leu Asp Pro Val Thr Thr Glu Glu Gln Val Leu Asp Val Lys Gly 
65                  70                  75                  80  


Tyr Leu Ser Lys Val Arg Gly Ile Ser Glu Val Leu Ala Arg Arg His 
                85                  90                  95      


Met Lys Val Ala Phe Phe Gly Arg Thr Ser Asn Gly Lys Ser Thr Val 
            100                 105                 110         


Ile Asn Ala Met Leu Trp Asp Lys Val Leu Pro Ser Gly Ile Gly His 
        115                 120                 125             


Thr Thr Asn Cys Phe Leu Arg Val Glu Gly Thr Asp Gly His Glu Ala 
    130                 135                 140                 


Phe Leu Leu Thr Glu Gly Ser Glu Glu Lys Arg Ser Ala Lys Thr Val 
145                 150                 155                 160 


Asn Gln Leu Ala His Ala Leu His Gln Asp Lys Gln Leu His Ala Gly 
                165                 170                 175     


Ser Leu Val Ser Val Met Trp Pro Asn Ser Lys Cys Pro Leu Leu Lys 
            180                 185                 190         


Asp Asp Leu Val Leu Met Asp Ser Pro Gly Ile Asp Val Thr Thr Glu 
        195                 200                 205             


Leu Asp Ser Trp Ile Asp Lys Phe Cys Leu Asp Ala Asp Val Phe Val 
    210                 215                 220                 


Leu Val Ala Asn Ser Glu Ser Thr Leu Met Gln Thr Glu Lys His Phe 
225                 230                 235                 240 


Phe His Lys Val Ser Glu Arg Leu Ser Arg Pro Asn Ile Phe Ile Leu 
                245                 250                 255     


Asn Asn Arg Trp Asp Ala Ser Ala Ser Glu Pro Glu Tyr Met Glu Glu 
            260                 265                 270         


Val Arg Arg Gln His Met Glu Arg Cys Thr Ser Phe Leu Val Asp Glu 
        275                 280                 285             


Leu Gly Val Val Asp Arg Ser Gln Ala Gly Asp Arg Ile Phe Phe Val 
    290                 295                 300                 


Ser Ala Lys Glu Val Leu Asn Ala Arg Ile Gln Lys Ala Gln Gly Met 
305                 310                 315                 320 


Pro Glu Gly Gly Gly Ala Leu Ala Glu Gly Phe Gln Val Arg Met Phe 
                325                 330                 335     


Glu Phe Gln Asn Phe Glu Arg Arg Phe Glu Glu Cys Ile Ser Gln Ser 
            340                 345                 350         


Ala Val Lys Thr Lys Phe Glu Gln His Thr Val Arg Ala Lys Gln Ile 
        355                 360                 365             


Ala Glu Ala Val Arg Leu Ile Met Asp Ser Leu His Met Ala Ala Arg 
    370                 375                 380                 


Glu Gln Gln Val Tyr Cys Glu Glu Met Arg Glu Glu Arg Gln Asp Arg 
385                 390                 395                 400 


Leu Lys Phe Ile Asp Lys Gln Leu Glu Leu Leu Ala Gln Asp Tyr Lys 
                405                 410                 415     


Leu Arg Ile Lys Gln Ile Thr Glu Glu Val Glu Arg Gln Val Ser Thr 
            420                 425                 430         


Ala Met Ala Glu Glu Ile Arg Arg Leu Ser Val Leu Val Asp Asp Tyr 
        435                 440                 445             


Gln Met Asp Phe His Pro Ser Pro Val Val Leu Lys Val Tyr Lys Asn 
    450                 455                 460                 


Glu Leu His Arg His Ile Glu Glu Gly Leu Gly Arg Asn Met Ser Asp 
465                 470                 475                 480 


Arg Cys Ser Thr Ala Ile Thr Asn Ser Leu Gln Thr Met Gln Gln Asp 
                485                 490                 495     


Met Ile Asp Gly Leu Lys Pro Leu Leu Pro Val Ser Val Arg Ser Gln 
            500                 505                 510         


Ile Asp Met Leu Val Pro Arg Gln Cys Phe Ser Leu Asn Tyr Asp Leu 
        515                 520                 525             


Asn Cys Asp Lys Leu Cys Ala Asp Phe Gln Glu Asp Ile Glu Phe His 
    530                 535                 540                 


Phe Ser Leu Gly Trp Thr Met Leu Val Asn Arg Phe Leu Gly Pro Lys 
545                 550                 555                 560 


Asn Ser Arg Arg Ala Leu Met Gly Tyr Asn Asp Gln Val Gln Arg Pro 
                565                 570                 575     


Ile Pro Leu Thr Pro Ala Asn Pro Ser Met Pro Pro Leu Pro Gln Gly 
            580                 585                 590         


Ser Leu Thr Gln Glu Glu Phe Met Val Ser Met Val Thr Gly Leu Ala 
        595                 600                 605             


Ser Leu Thr Ser Arg Thr Ser Met Gly Ile Leu Val Val Gly Gly Val 
    610                 615                 620                 


Val Trp Lys Ala Val Gly Trp Arg Leu Ile Ala Leu Ser Phe Gly Leu 
625                 630                 635                 640 


Tyr Gly Leu Leu Tyr Val Tyr Glu Arg Leu Thr Trp Thr Thr Lys Ala 
                645                 650                 655     


Lys Glu Arg Ala Phe Lys Arg Gln Phe Val Glu His Ala Ser Glu Lys 
            660                 665                 670         


Leu Gln Leu Val Ile Ser Tyr Thr Gly Ser Asn Cys Ser His Gln Val 
        675                 680                 685             


Gln Gln Glu Leu Ser Gly Thr Phe Ala His Leu Cys Gln Gln Val Asp 
    690                 695                 700                 


Val Thr Arg Glu Asn Leu Glu Gln Glu Ile Ala Ala Met Asn Lys Lys 
705                 710                 715                 720 


Ile Glu Val Leu Asp Ser Leu Gln Ser Lys Ala Lys Leu Leu Arg Asn 
                725                 730                 735     


Lys Ala Gly Trp Leu Asp Ser Glu Leu Asn Met Phe Thr His Gln Tyr 
            740                 745                 750         


Leu Gln Pro Ser Arg 
        755         


<210>  11
<211>  76
<212>  RNA
<213>  Homo Sapiens

<400>  11
gacuauaagc ugcgaauuac augaggccuu ucuccuuagc aacucuaucg ucacaguggu       60

ggacgauuac cagaug                                                       76


<210>  12
<211>  76
<212>  RNA
<213>  Homo Sapiens

<400>  12
cgaugaagua aacgccuuac augauaggag gaaacgaaca gaauauaugg aagacgugga       60

aguucuuagu gcuaga                                                       76


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13
tgttgttgtg acgattgctc                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14
ttacgggact agaaaatcag                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
tgctgtgaca tttaagcggt                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16
cgaatgctgt gacatttaag                                                   20


<210>  17
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
tttataaaat gcaataggt                                                    19


