                         SEQUENCE LISTING

<110>  The Regents of the University of California
 
<120>  COMPOSITIONS AND METHODS FOR MODULATING TCF4 GENE EXPRESSION AND 
       TREATING PITT HOPKINS SYNDROME

<130>  00015-390WO1

<140>  Not yet assigned
<141>  2021-09-30

<150>  US 63/085,878
<151>  2020-09-30

<160>  55    

<170>  PatentIn version 3.5

<210>  1
<211>  2016
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(2016)

<400>  1
atg cat cac caa cag cga atg gct gcc tta ggg acg gac aaa gag ctg         48
Met His His Gln Gln Arg Met Ala Ala Leu Gly Thr Asp Lys Glu Leu           
1               5                   10                  15                

agt gat tta ctg gat ttc agt gcg atg ttt tca cct cct gtg agc agt         96
Ser Asp Leu Leu Asp Phe Ser Ala Met Phe Ser Pro Pro Val Ser Ser           
            20                  25                  30                    

ggg aaa aat gga cca act tct ttg gca agt gga cat ttt act ggc tca        144
Gly Lys Asn Gly Pro Thr Ser Leu Ala Ser Gly His Phe Thr Gly Ser           
        35                  40                  45                        

aat gta gaa gac aga agt agc tca ggg tcc tgg ggg aat gga gga cat        192
Asn Val Glu Asp Arg Ser Ser Ser Gly Ser Trp Gly Asn Gly Gly His           
    50                  55                  60                            

cca agc ccg tcc agg aac tat gga gat ggg act ccc tat gac cac atg        240
Pro Ser Pro Ser Arg Asn Tyr Gly Asp Gly Thr Pro Tyr Asp His Met           
65                  70                  75                  80            

acc agc agg gac ctt ggg tca cat gac aat ctc tct cca cct ttt gtc        288
Thr Ser Arg Asp Leu Gly Ser His Asp Asn Leu Ser Pro Pro Phe Val           
                85                  90                  95                

aat tcc aga ata caa agt aaa aca gaa agg ggc tca tac tca tct tat        336
Asn Ser Arg Ile Gln Ser Lys Thr Glu Arg Gly Ser Tyr Ser Ser Tyr           
            100                 105                 110                   

ggg aga gaa tca aac tta cag ggt tgc cac cag cag agt ctc ctt gga        384
Gly Arg Glu Ser Asn Leu Gln Gly Cys His Gln Gln Ser Leu Leu Gly           
        115                 120                 125                       

ggt gac atg gat atg ggc aac cca gga acc ctt tcg ccc acc aaa cct        432
Gly Asp Met Asp Met Gly Asn Pro Gly Thr Leu Ser Pro Thr Lys Pro           
    130                 135                 140                           

ggt tcc cag tac tat cag tat tct agc aat aat ccc cga agg agg cct        480
Gly Ser Gln Tyr Tyr Gln Tyr Ser Ser Asn Asn Pro Arg Arg Arg Pro           
145                 150                 155                 160           

ctt cac agt agt gcc atg gag gtg cag aca aag aaa gtt cga aaa gtt        528
Leu His Ser Ser Ala Met Glu Val Gln Thr Lys Lys Val Arg Lys Val           
                165                 170                 175               

cct cca ggt ttg cca tct tca gtc tat gct cca tca gca agc act gcc        576
Pro Pro Gly Leu Pro Ser Ser Val Tyr Ala Pro Ser Ala Ser Thr Ala           
            180                 185                 190                   

gac tac aat agg gac tcg cca ggc tat cct tcc tcc aaa cca gca acc        624
Asp Tyr Asn Arg Asp Ser Pro Gly Tyr Pro Ser Ser Lys Pro Ala Thr           
        195                 200                 205                       

agc act ttc cct agc tcc ttc ttc atg caa gat ggc cat cac agc agt        672
Ser Thr Phe Pro Ser Ser Phe Phe Met Gln Asp Gly His His Ser Ser           
    210                 215                 220                           

gac cct tgg agc tcc tcc agt ggg atg aat cag cct ggc tat gca gga        720
Asp Pro Trp Ser Ser Ser Ser Gly Met Asn Gln Pro Gly Tyr Ala Gly           
225                 230                 235                 240           

atg ttg ggc aac tct tct cat att cca cag tcc agc agc tac tgt agc        768
Met Leu Gly Asn Ser Ser His Ile Pro Gln Ser Ser Ser Tyr Cys Ser           
                245                 250                 255               

ctg cat cca cat gaa cgt ttg agc tat cca tca cac tcc tca gca gac        816
Leu His Pro His Glu Arg Leu Ser Tyr Pro Ser His Ser Ser Ala Asp           
            260                 265                 270                   

atc aat tcc agt ctt cct ccg atg tcc act ttc cat cgt agt ggt aca        864
Ile Asn Ser Ser Leu Pro Pro Met Ser Thr Phe His Arg Ser Gly Thr           
        275                 280                 285                       

aac cat tac agc acc tct tcc tgt acg cct cct gcc aac ggg aca gac        912
Asn His Tyr Ser Thr Ser Ser Cys Thr Pro Pro Ala Asn Gly Thr Asp           
    290                 295                 300                           

agt ata atg gca aat aga gga agc ggg gca gcc ggc agc tcc cag act        960
Ser Ile Met Ala Asn Arg Gly Ser Gly Ala Ala Gly Ser Ser Gln Thr           
305                 310                 315                 320           

gga gat gct ctg ggg aaa gca ctt gct tcg atc tat tct cca gat cac       1008
Gly Asp Ala Leu Gly Lys Ala Leu Ala Ser Ile Tyr Ser Pro Asp His           
                325                 330                 335               

act aac aac agc ttt tca tca aac cct tca act cct gtt ggc tct cct       1056
Thr Asn Asn Ser Phe Ser Ser Asn Pro Ser Thr Pro Val Gly Ser Pro           
            340                 345                 350                   

cca tct ctc tca gca ggc aca gct gtt tgg tct aga aat gga gga cag       1104
Pro Ser Leu Ser Ala Gly Thr Ala Val Trp Ser Arg Asn Gly Gly Gln           
        355                 360                 365                       

gcc tca tcg tct cct aat tat gaa gga ccc tta cac tct ttg caa agc       1152
Ala Ser Ser Ser Pro Asn Tyr Glu Gly Pro Leu His Ser Leu Gln Ser           
    370                 375                 380                           

cga att gaa gat cgt tta gaa aga ctg gat gat gct att cat gtt ctc       1200
Arg Ile Glu Asp Arg Leu Glu Arg Leu Asp Asp Ala Ile His Val Leu           
385                 390                 395                 400           

cgg aac cat gca gtg ggc cca tcc aca gct atg cct ggt ggt cat ggg       1248
Arg Asn His Ala Val Gly Pro Ser Thr Ala Met Pro Gly Gly His Gly           
                405                 410                 415               

gac atg cat gga atc att gga cct tct cat aat gga gcc atg ggt ggt       1296
Asp Met His Gly Ile Ile Gly Pro Ser His Asn Gly Ala Met Gly Gly           
            420                 425                 430                   

ctg ggc tca ggg tat gga acc ggc ctt ctt tca gcc aac aga cat tca       1344
Leu Gly Ser Gly Tyr Gly Thr Gly Leu Leu Ser Ala Asn Arg His Ser           
        435                 440                 445                       

ctc atg gtg ggg acc cat cgt gaa gat ggc gtg gcc ctg aga ggc agc       1392
Leu Met Val Gly Thr His Arg Glu Asp Gly Val Ala Leu Arg Gly Ser           
    450                 455                 460                           

cat tct ctt ctg cca aac cag gtt ccg gtt cca cag ctt cct gtc cag       1440
His Ser Leu Leu Pro Asn Gln Val Pro Val Pro Gln Leu Pro Val Gln           
465                 470                 475                 480           

tct gcg act tcc cct gac ctg aac cca ccc cag gac cct tac aga ggc       1488
Ser Ala Thr Ser Pro Asp Leu Asn Pro Pro Gln Asp Pro Tyr Arg Gly           
                485                 490                 495               

atg cca cca gga cta cag ggg cag agt gtc tcc tct ggc agc tct gag       1536
Met Pro Pro Gly Leu Gln Gly Gln Ser Val Ser Ser Gly Ser Ser Glu           
            500                 505                 510                   

atc aaa tcc gat gac gag ggt gat gag aac ctg caa gac acg aaa tct       1584
Ile Lys Ser Asp Asp Glu Gly Asp Glu Asn Leu Gln Asp Thr Lys Ser           
        515                 520                 525                       

tcg gag gac aag aaa tta gat gac gac aag aag gat atc aaa tca att       1632
Ser Glu Asp Lys Lys Leu Asp Asp Asp Lys Lys Asp Ile Lys Ser Ile           
    530                 535                 540                           

act agg tca aga tct agc aat aat gac gat gag gac ctg aca cca gag       1680
Thr Arg Ser Arg Ser Ser Asn Asn Asp Asp Glu Asp Leu Thr Pro Glu           
545                 550                 555                 560           

cag aag gca gag cgt gag aag gag cgg agg atg gcc aac aat gcc cga       1728
Gln Lys Ala Glu Arg Glu Lys Glu Arg Arg Met Ala Asn Asn Ala Arg           
                565                 570                 575               

gag cgt ctg cgg gtc cgt gac atc aac gag gct ttc aaa gag ctc ggc       1776
Glu Arg Leu Arg Val Arg Asp Ile Asn Glu Ala Phe Lys Glu Leu Gly           
            580                 585                 590                   

cgc atg gtg cag ctc cac ctc aag agt gac aag ccc cag acc aag ctc       1824
Arg Met Val Gln Leu His Leu Lys Ser Asp Lys Pro Gln Thr Lys Leu           
        595                 600                 605                       

ctg atc ctc cac cag gcg gtg gcc gtc atc ctc agt ctg gag cag caa       1872
Leu Ile Leu His Gln Ala Val Ala Val Ile Leu Ser Leu Glu Gln Gln           
    610                 615                 620                           

gtc cga gaa agg aat ctg aat ccg aaa gct gcg tgt ctg aaa aga agg       1920
Val Arg Glu Arg Asn Leu Asn Pro Lys Ala Ala Cys Leu Lys Arg Arg           
625                 630                 635                 640           

gag gaa gag aag gtg tcc tca gag cct ccc cct ctc tcc ttg gcc ggc       1968
Glu Glu Glu Lys Val Ser Ser Glu Pro Pro Pro Leu Ser Leu Ala Gly           
                645                 650                 655               

cca cac cct gga atg gga gac gca tcg aat cac atg gga cag atg taa       2016
Pro His Pro Gly Met Gly Asp Ala Ser Asn His Met Gly Gln Met               
            660                 665                 670                   


<210>  2
<211>  671
<212>  PRT
<213>  Homo sapiens

<400>  2

Met His His Gln Gln Arg Met Ala Ala Leu Gly Thr Asp Lys Glu Leu 
1               5                   10                  15      


Ser Asp Leu Leu Asp Phe Ser Ala Met Phe Ser Pro Pro Val Ser Ser 
            20                  25                  30          


Gly Lys Asn Gly Pro Thr Ser Leu Ala Ser Gly His Phe Thr Gly Ser 
        35                  40                  45              


Asn Val Glu Asp Arg Ser Ser Ser Gly Ser Trp Gly Asn Gly Gly His 
    50                  55                  60                  


Pro Ser Pro Ser Arg Asn Tyr Gly Asp Gly Thr Pro Tyr Asp His Met 
65                  70                  75                  80  


Thr Ser Arg Asp Leu Gly Ser His Asp Asn Leu Ser Pro Pro Phe Val 
                85                  90                  95      


Asn Ser Arg Ile Gln Ser Lys Thr Glu Arg Gly Ser Tyr Ser Ser Tyr 
            100                 105                 110         


Gly Arg Glu Ser Asn Leu Gln Gly Cys His Gln Gln Ser Leu Leu Gly 
        115                 120                 125             


Gly Asp Met Asp Met Gly Asn Pro Gly Thr Leu Ser Pro Thr Lys Pro 
    130                 135                 140                 


Gly Ser Gln Tyr Tyr Gln Tyr Ser Ser Asn Asn Pro Arg Arg Arg Pro 
145                 150                 155                 160 


Leu His Ser Ser Ala Met Glu Val Gln Thr Lys Lys Val Arg Lys Val 
                165                 170                 175     


Pro Pro Gly Leu Pro Ser Ser Val Tyr Ala Pro Ser Ala Ser Thr Ala 
            180                 185                 190         


Asp Tyr Asn Arg Asp Ser Pro Gly Tyr Pro Ser Ser Lys Pro Ala Thr 
        195                 200                 205             


Ser Thr Phe Pro Ser Ser Phe Phe Met Gln Asp Gly His His Ser Ser 
    210                 215                 220                 


Asp Pro Trp Ser Ser Ser Ser Gly Met Asn Gln Pro Gly Tyr Ala Gly 
225                 230                 235                 240 


Met Leu Gly Asn Ser Ser His Ile Pro Gln Ser Ser Ser Tyr Cys Ser 
                245                 250                 255     


Leu His Pro His Glu Arg Leu Ser Tyr Pro Ser His Ser Ser Ala Asp 
            260                 265                 270         


Ile Asn Ser Ser Leu Pro Pro Met Ser Thr Phe His Arg Ser Gly Thr 
        275                 280                 285             


Asn His Tyr Ser Thr Ser Ser Cys Thr Pro Pro Ala Asn Gly Thr Asp 
    290                 295                 300                 


Ser Ile Met Ala Asn Arg Gly Ser Gly Ala Ala Gly Ser Ser Gln Thr 
305                 310                 315                 320 


Gly Asp Ala Leu Gly Lys Ala Leu Ala Ser Ile Tyr Ser Pro Asp His 
                325                 330                 335     


Thr Asn Asn Ser Phe Ser Ser Asn Pro Ser Thr Pro Val Gly Ser Pro 
            340                 345                 350         


Pro Ser Leu Ser Ala Gly Thr Ala Val Trp Ser Arg Asn Gly Gly Gln 
        355                 360                 365             


Ala Ser Ser Ser Pro Asn Tyr Glu Gly Pro Leu His Ser Leu Gln Ser 
    370                 375                 380                 


Arg Ile Glu Asp Arg Leu Glu Arg Leu Asp Asp Ala Ile His Val Leu 
385                 390                 395                 400 


Arg Asn His Ala Val Gly Pro Ser Thr Ala Met Pro Gly Gly His Gly 
                405                 410                 415     


Asp Met His Gly Ile Ile Gly Pro Ser His Asn Gly Ala Met Gly Gly 
            420                 425                 430         


Leu Gly Ser Gly Tyr Gly Thr Gly Leu Leu Ser Ala Asn Arg His Ser 
        435                 440                 445             


Leu Met Val Gly Thr His Arg Glu Asp Gly Val Ala Leu Arg Gly Ser 
    450                 455                 460                 


His Ser Leu Leu Pro Asn Gln Val Pro Val Pro Gln Leu Pro Val Gln 
465                 470                 475                 480 


Ser Ala Thr Ser Pro Asp Leu Asn Pro Pro Gln Asp Pro Tyr Arg Gly 
                485                 490                 495     


Met Pro Pro Gly Leu Gln Gly Gln Ser Val Ser Ser Gly Ser Ser Glu 
            500                 505                 510         


Ile Lys Ser Asp Asp Glu Gly Asp Glu Asn Leu Gln Asp Thr Lys Ser 
        515                 520                 525             


Ser Glu Asp Lys Lys Leu Asp Asp Asp Lys Lys Asp Ile Lys Ser Ile 
    530                 535                 540                 


Thr Arg Ser Arg Ser Ser Asn Asn Asp Asp Glu Asp Leu Thr Pro Glu 
545                 550                 555                 560 


Gln Lys Ala Glu Arg Glu Lys Glu Arg Arg Met Ala Asn Asn Ala Arg 
                565                 570                 575     


Glu Arg Leu Arg Val Arg Asp Ile Asn Glu Ala Phe Lys Glu Leu Gly 
            580                 585                 590         


Arg Met Val Gln Leu His Leu Lys Ser Asp Lys Pro Gln Thr Lys Leu 
        595                 600                 605             


Leu Ile Leu His Gln Ala Val Ala Val Ile Leu Ser Leu Glu Gln Gln 
    610                 615                 620                 


Val Arg Glu Arg Asn Leu Asn Pro Lys Ala Ala Cys Leu Lys Arg Arg 
625                 630                 635                 640 


Glu Glu Glu Lys Val Ser Ser Glu Pro Pro Pro Leu Ser Leu Ala Gly 
                645                 650                 655     


Pro His Pro Gly Met Gly Asp Ala Ser Asn His Met Gly Gln Met 
            660                 665                 670     


<210>  3
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mini-Promoter

<400>  3
agagggtata taatggaagc tcgacttcca g                                      31


<210>  4
<211>  2204
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Expression Cassette ARN65

<400>  4
gaattcacct gcaagaacac ctgcaagaac acctgcaaga acacctgcaa gaacacctgc       60

aagaacacct gcaagaacac ctgcaagaac acctgcaaga acacctgcaa gaacacctgc      120

aagaacacct gcaagaacac ctgcaagaga gggtatataa tggaagctcg acttccagat      180

gcatcaccaa cagcgaatgg ctgccttagg gacggacaaa gagctgagtg atttactgga      240

tttcagtgcg atgttttcac ctcctgtgag cagtgggaaa aatggaccaa cttctttggc      300

aagtggacat tttactggct caaatgtaga agacagaagt agctcagggt cctgggggaa      360

tggaggacat ccaagcccgt ccaggaacta tggagatggg actccctatg accacatgac      420

cagcagggac cttgggtcac atgacaatct ctctccacct tttgtcaatt ccagaataca      480

aagtaaaaca gaaaggggct catactcatc ttatgggaga gaatcaaact tacagggttg      540

ccaccagcag agtctccttg gaggtgacat ggatatgggc aacccaggaa ccctttcgcc      600

caccaaacct ggttcccagt actatcagta ttctagcaat aatccccgaa ggaggcctct      660

tcacagtagt gccatggagg tgcagacaaa gaaagttcga aaagttcctc caggtttgcc      720

atcttcagtc tatgctccat cagcaagcac tgccgactac aatagggact cgccaggcta      780

tccttcctcc aaaccagcaa ccagcacttt ccctagctcc ttcttcatgc aagatggcca      840

tcacagcagt gacccttgga gctcctccag tgggatgaat cagcctggct atgcaggaat      900

gttgggcaac tcttctcata ttccacagtc cagcagctac tgtagcctgc atccacatga      960

acgtttgagc tatccatcac actcctcagc agacatcaat tccagtcttc ctccgatgtc     1020

cactttccat cgtagtggta caaaccatta cagcacctct tcctgtacgc ctcctgccaa     1080

cgggacagac agtataatgg caaatagagg aagcggggca gccggcagct cccagactgg     1140

agatgctctg gggaaagcac ttgcttcgat ctattctcca gatcacacta acaacagctt     1200

ttcatcaaac ccttcaactc ctgttggctc tcctccatct ctctcagcag gcacagctgt     1260

ttggtctaga aatggaggac aggcctcatc gtctcctaat tatgaaggac ccttacactc     1320

tttgcaaagc cgaattgaag atcgtttaga aagactggat gatgctattc atgttctccg     1380

gaaccatgca gtgggcccat ccacagctat gcctggtggt catggggaca tgcatggaat     1440

cattggacct tctcataatg gagccatggg tggtctgggc tcagggtatg gaaccggcct     1500

tctttcagcc aacagacatt cactcatggt ggggacccat cgtgaagatg gcgtggccct     1560

gagaggcagc cattctcttc tgccaaacca ggttccggtt ccacagcttc ctgtccagtc     1620

tgcgacttcc cctgacctga acccacccca ggacccttac agaggcatgc caccaggact     1680

acaggggcag agtgtctcct ctggcagctc tgagatcaaa tccgatgacg agggtgatga     1740

gaacctgcaa gacacgaaat cttcggagga caagaaatta gatgacgaca agaaggatat     1800

caaatcaatt actaggtcaa gatctagcaa taatgacgat gaggacctga caccagagca     1860

gaaggcagag cgtgagaagg agcggaggat ggccaacaat gcccgagagc gtctgcgggt     1920

ccgtgacatc aacgaggctt tcaaagagct cggccgcatg gtgcagctcc acctcaagag     1980

tgacaagccc cagaccaagc tcctgatcct ccaccaggcg gtggccgtca tcctcagtct     2040

ggagcagcaa gtccgagaaa ggaatctgaa tccgaaagct gcgtgtctga aaagaaggga     2100

ggaagagaag gtgtcctcag agcctccccc tctctccttg gccggcccac accctggaat     2160

gggagacgca tcgaatcaca tgggacagat gtaactcgag gata                      2204


<210>  5
<211>  2063
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Expression Cassette ARN60

<400>  5
gaattcagag ggtatataat ggaagctcga cttccagatg catcaccaac agcgaatggc       60

tgccttaggg acggacaaag agctgagtga tttactggat ttcagtgcga tgttttcacc      120

tcctgtgagc agtgggaaaa atggaccaac ttctttggca agtggacatt ttactggctc      180

aaatgtagaa gacagaagta gctcagggtc ctgggggaat ggaggacatc caagcccgtc      240

caggaactat ggagatggga ctccctatga ccacatgacc agcagggacc ttgggtcaca      300

tgacaatctc tctccacctt ttgtcaattc cagaatacaa agtaaaacag aaaggggctc      360

atactcatct tatgggagag aatcaaactt acagggttgc caccagcaga gtctccttgg      420

aggtgacatg gatatgggca acccaggaac cctttcgccc accaaacctg gttcccagta      480

ctatcagtat tctagcaata atccccgaag gaggcctctt cacagtagtg ccatggaggt      540

gcagacaaag aaagttcgaa aagttcctcc aggtttgcca tcttcagtct atgctccatc      600

agcaagcact gccgactaca atagggactc gccaggctat ccttcctcca aaccagcaac      660

cagcactttc cctagctcct tcttcatgca agatggccat cacagcagtg acccttggag      720

ctcctccagt gggatgaatc agcctggcta tgcaggaatg ttgggcaact cttctcatat      780

tccacagtcc agcagctact gtagcctgca tccacatgaa cgtttgagct atccatcaca      840

ctcctcagca gacatcaatt ccagtcttcc tccgatgtcc actttccatc gtagtggtac      900

aaaccattac agcacctctt cctgtacgcc tcctgccaac gggacagaca gtataatggc      960

aaatagagga agcggggcag ccggcagctc ccagactgga gatgctctgg ggaaagcact     1020

tgcttcgatc tattctccag atcacactaa caacagcttt tcatcaaacc cttcaactcc     1080

tgttggctct cctccatctc tctcagcagg cacagctgtt tggtctagaa atggaggaca     1140

ggcctcatcg tctcctaatt atgaaggacc cttacactct ttgcaaagcc gaattgaaga     1200

tcgtttagaa agactggatg atgctattca tgttctccgg aaccatgcag tgggcccatc     1260

cacagctatg cctggtggtc atggggacat gcatggaatc attggacctt ctcataatgg     1320

agccatgggt ggtctgggct cagggtatgg aaccggcctt ctttcagcca acagacattc     1380

actcatggtg gggacccatc gtgaagatgg cgtggccctg agaggcagcc attctcttct     1440

gccaaaccag gttccggttc cacagcttcc tgtccagtct gcgacttccc ctgacctgaa     1500

cccaccccag gacccttaca gaggcatgcc accaggacta caggggcaga gtgtctcctc     1560

tggcagctct gagatcaaat ccgatgacga gggtgatgag aacctgcaag acacgaaatc     1620

ttcggaggac aagaaattag atgacgacaa gaaggatatc aaatcaatta ctaggtcaag     1680

atctagcaat aatgacgatg aggacctgac accagagcag aaggcagagc gtgagaagga     1740

gcggaggatg gccaacaatg cccgagagcg tctgcgggtc cgtgacatca acgaggcttt     1800

caaagagctc ggccgcatgg tgcagctcca cctcaagagt gacaagcccc agaccaagct     1860

cctgatcctc caccaggcgg tggccgtcat cctcagtctg gagcagcaag tccgagaaag     1920

gaatctgaat ccgaaagctg cgtgtctgaa aagaagggag gaagagaagg tgtcctcaga     1980

gcctccccct ctctccttgg ccggcccaca ccctggaatg ggagacgcat cgaatcacat     2040

gggacagatg taactcgagg ata                                             2063


<210>  6
<211>  2075
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Expression Cassette ARN61

<400>  6
gaattcaaca cctgcaagag agggtatata atggaagctc gacttccaga tgcatcacca       60

acagcgaatg gctgccttag ggacggacaa agagctgagt gatttactgg atttcagtgc      120

gatgttttca cctcctgtga gcagtgggaa aaatggacca acttctttgg caagtggaca      180

ttttactggc tcaaatgtag aagacagaag tagctcaggg tcctggggga atggaggaca      240

tccaagcccg tccaggaact atggagatgg gactccctat gaccacatga ccagcaggga      300

ccttgggtca catgacaatc tctctccacc ttttgtcaat tccagaatac aaagtaaaac      360

agaaaggggc tcatactcat cttatgggag agaatcaaac ttacagggtt gccaccagca      420

gagtctcctt ggaggtgaca tggatatggg caacccagga accctttcgc ccaccaaacc      480

tggttcccag tactatcagt attctagcaa taatccccga aggaggcctc ttcacagtag      540

tgccatggag gtgcagacaa agaaagttcg aaaagttcct ccaggtttgc catcttcagt      600

ctatgctcca tcagcaagca ctgccgacta caatagggac tcgccaggct atccttcctc      660

caaaccagca accagcactt tccctagctc cttcttcatg caagatggcc atcacagcag      720

tgacccttgg agctcctcca gtgggatgaa tcagcctggc tatgcaggaa tgttgggcaa      780

ctcttctcat attccacagt ccagcagcta ctgtagcctg catccacatg aacgtttgag      840

ctatccatca cactcctcag cagacatcaa ttccagtctt cctccgatgt ccactttcca      900

tcgtagtggt acaaaccatt acagcacctc ttcctgtacg cctcctgcca acgggacaga      960

cagtataatg gcaaatagag gaagcggggc agccggcagc tcccagactg gagatgctct     1020

ggggaaagca cttgcttcga tctattctcc agatcacact aacaacagct tttcatcaaa     1080

cccttcaact cctgttggct ctcctccatc tctctcagca ggcacagctg tttggtctag     1140

aaatggagga caggcctcat cgtctcctaa ttatgaagga cccttacact ctttgcaaag     1200

ccgaattgaa gatcgtttag aaagactgga tgatgctatt catgttctcc ggaaccatgc     1260

agtgggccca tccacagcta tgcctggtgg tcatggggac atgcatggaa tcattggacc     1320

ttctcataat ggagccatgg gtggtctggg ctcagggtat ggaaccggcc ttctttcagc     1380

caacagacat tcactcatgg tggggaccca tcgtgaagat ggcgtggccc tgagaggcag     1440

ccattctctt ctgccaaacc aggttccggt tccacagctt cctgtccagt ctgcgacttc     1500

ccctgacctg aacccacccc aggaccctta cagaggcatg ccaccaggac tacaggggca     1560

gagtgtctcc tctggcagct ctgagatcaa atccgatgac gagggtgatg agaacctgca     1620

agacacgaaa tcttcggagg acaagaaatt agatgacgac aagaaggata tcaaatcaat     1680

tactaggtca agatctagca ataatgacga tgaggacctg acaccagagc agaaggcaga     1740

gcgtgagaag gagcggagga tggccaacaa tgcccgagag cgtctgcggg tccgtgacat     1800

caacgaggct ttcaaagagc tcggccgcat ggtgcagctc cacctcaaga gtgacaagcc     1860

ccagaccaag ctcctgatcc tccaccaggc ggtggccgtc atcctcagtc tggagcagca     1920

agtccgagaa aggaatctga atccgaaagc tgcgtgtctg aaaagaaggg aggaagagaa     1980

ggtgtcctca gagcctcccc ctctctcctt ggccggccca caccctggaa tgggagacgc     2040

atcgaatcac atgggacaga tgtaactcga ggata                                2075


<210>  7
<211>  2099
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Expression Cassette ARN62

<400>  7
gaattcaaca cctgcaagaa cacctgcaag aacacctgca agagagggta tataatggaa       60

gctcgacttc cagatgcatc accaacagcg aatggctgcc ttagggacgg acaaagagct      120

gagtgattta ctggatttca gtgcgatgtt ttcacctcct gtgagcagtg ggaaaaatgg      180

accaacttct ttggcaagtg gacattttac tggctcaaat gtagaagaca gaagtagctc      240

agggtcctgg gggaatggag gacatccaag cccgtccagg aactatggag atgggactcc      300

ctatgaccac atgaccagca gggaccttgg gtcacatgac aatctctctc caccttttgt      360

caattccaga atacaaagta aaacagaaag gggctcatac tcatcttatg ggagagaatc      420

aaacttacag ggttgccacc agcagagtct ccttggaggt gacatggata tgggcaaccc      480

aggaaccctt tcgcccacca aacctggttc ccagtactat cagtattcta gcaataatcc      540

ccgaaggagg cctcttcaca gtagtgccat ggaggtgcag acaaagaaag ttcgaaaagt      600

tcctccaggt ttgccatctt cagtctatgc tccatcagca agcactgccg actacaatag      660

ggactcgcca ggctatcctt cctccaaacc agcaaccagc actttcccta gctccttctt      720

catgcaagat ggccatcaca gcagtgaccc ttggagctcc tccagtggga tgaatcagcc      780

tggctatgca ggaatgttgg gcaactcttc tcatattcca cagtccagca gctactgtag      840

cctgcatcca catgaacgtt tgagctatcc atcacactcc tcagcagaca tcaattccag      900

tcttcctccg atgtccactt tccatcgtag tggtacaaac cattacagca cctcttcctg      960

tacgcctcct gccaacggga cagacagtat aatggcaaat agaggaagcg gggcagccgg     1020

cagctcccag actggagatg ctctggggaa agcacttgct tcgatctatt ctccagatca     1080

cactaacaac agcttttcat caaacccttc aactcctgtt ggctctcctc catctctctc     1140

agcaggcaca gctgtttggt ctagaaatgg aggacaggcc tcatcgtctc ctaattatga     1200

aggaccctta cactctttgc aaagccgaat tgaagatcgt ttagaaagac tggatgatgc     1260

tattcatgtt ctccggaacc atgcagtggg cccatccaca gctatgcctg gtggtcatgg     1320

ggacatgcat ggaatcattg gaccttctca taatggagcc atgggtggtc tgggctcagg     1380

gtatggaacc ggccttcttt cagccaacag acattcactc atggtgggga cccatcgtga     1440

agatggcgtg gccctgagag gcagccattc tcttctgcca aaccaggttc cggttccaca     1500

gcttcctgtc cagtctgcga cttcccctga cctgaaccca ccccaggacc cttacagagg     1560

catgccacca ggactacagg ggcagagtgt ctcctctggc agctctgaga tcaaatccga     1620

tgacgagggt gatgagaacc tgcaagacac gaaatcttcg gaggacaaga aattagatga     1680

cgacaagaag gatatcaaat caattactag gtcaagatct agcaataatg acgatgagga     1740

cctgacacca gagcagaagg cagagcgtga gaaggagcgg aggatggcca acaatgcccg     1800

agagcgtctg cgggtccgtg acatcaacga ggctttcaaa gagctcggcc gcatggtgca     1860

gctccacctc aagagtgaca agccccagac caagctcctg atcctccacc aggcggtggc     1920

cgtcatcctc agtctggagc agcaagtccg agaaaggaat ctgaatccga aagctgcgtg     1980

tctgaaaaga agggaggaag agaaggtgtc ctcagagcct ccccctctct ccttggccgg     2040

cccacaccct ggaatgggag acgcatcgaa tcacatggga cagatgtaac tcgaggata      2099


<210>  8
<211>  2135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Expression Cassette ARN63

<400>  8
gaattcaaca cctgcaagaa cacctgcaag aacacctgca agaacacctg caagaacacc       60

tgcaagaaca cctgcaagag agggtatata atggaagctc gacttccaga tgcatcacca      120

acagcgaatg gctgccttag ggacggacaa agagctgagt gatttactgg atttcagtgc      180

gatgttttca cctcctgtga gcagtgggaa aaatggacca acttctttgg caagtggaca      240

ttttactggc tcaaatgtag aagacagaag tagctcaggg tcctggggga atggaggaca      300

tccaagcccg tccaggaact atggagatgg gactccctat gaccacatga ccagcaggga      360

ccttgggtca catgacaatc tctctccacc ttttgtcaat tccagaatac aaagtaaaac      420

agaaaggggc tcatactcat cttatgggag agaatcaaac ttacagggtt gccaccagca      480

gagtctcctt ggaggtgaca tggatatggg caacccagga accctttcgc ccaccaaacc      540

tggttcccag tactatcagt attctagcaa taatccccga aggaggcctc ttcacagtag      600

tgccatggag gtgcagacaa agaaagttcg aaaagttcct ccaggtttgc catcttcagt      660

ctatgctcca tcagcaagca ctgccgacta caatagggac tcgccaggct atccttcctc      720

caaaccagca accagcactt tccctagctc cttcttcatg caagatggcc atcacagcag      780

tgacccttgg agctcctcca gtgggatgaa tcagcctggc tatgcaggaa tgttgggcaa      840

ctcttctcat attccacagt ccagcagcta ctgtagcctg catccacatg aacgtttgag      900

ctatccatca cactcctcag cagacatcaa ttccagtctt cctccgatgt ccactttcca      960

tcgtagtggt acaaaccatt acagcacctc ttcctgtacg cctcctgcca acgggacaga     1020

cagtataatg gcaaatagag gaagcggggc agccggcagc tcccagactg gagatgctct     1080

ggggaaagca cttgcttcga tctattctcc agatcacact aacaacagct tttcatcaaa     1140

cccttcaact cctgttggct ctcctccatc tctctcagca ggcacagctg tttggtctag     1200

aaatggagga caggcctcat cgtctcctaa ttatgaagga cccttacact ctttgcaaag     1260

ccgaattgaa gatcgtttag aaagactgga tgatgctatt catgttctcc ggaaccatgc     1320

agtgggccca tccacagcta tgcctggtgg tcatggggac atgcatggaa tcattggacc     1380

ttctcataat ggagccatgg gtggtctggg ctcagggtat ggaaccggcc ttctttcagc     1440

caacagacat tcactcatgg tggggaccca tcgtgaagat ggcgtggccc tgagaggcag     1500

ccattctctt ctgccaaacc aggttccggt tccacagctt cctgtccagt ctgcgacttc     1560

ccctgacctg aacccacccc aggaccctta cagaggcatg ccaccaggac tacaggggca     1620

gagtgtctcc tctggcagct ctgagatcaa atccgatgac gagggtgatg agaacctgca     1680

agacacgaaa tcttcggagg acaagaaatt agatgacgac aagaaggata tcaaatcaat     1740

tactaggtca agatctagca ataatgacga tgaggacctg acaccagagc agaaggcaga     1800

gcgtgagaag gagcggagga tggccaacaa tgcccgagag cgtctgcggg tccgtgacat     1860

caacgaggct ttcaaagagc tcggccgcat ggtgcagctc cacctcaaga gtgacaagcc     1920

ccagaccaag ctcctgatcc tccaccaggc ggtggccgtc atcctcagtc tggagcagca     1980

agtccgagaa aggaatctga atccgaaagc tgcgtgtctg aaaagaaggg aggaagagaa     2040

ggtgtcctca gagcctcccc ctctctcctt ggccggccca caccctggaa tgggagacgc     2100

atcgaatcac atgggacaga tgtaactcga ggata                                2135


<210>  9
<211>  6294
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAAV(exp)-SYN1>hTCF4

<400>  9
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc ttctagacaa ctttgtatag aaaagttgct gcagagggcc      180

ctgcgtatga gtgcaagtgg gttttaggac caggatgagg cggggtgggg gtgcctacct      240

gacgaccgac cccgacccac tggacaagca cccaaccccc attccccaaa ttgcgcatcc      300

cctatcagag agggggaggg gaaacaggat gcggcgaggc gcgtgcgcac tgccagcttc      360

agcaccgcgg acagtgcctt cgcccccgcc tggcggcgcg cgccaccgcc gcctcagcac      420

tgaaggcgcg ctgacgtcac tcgccggtcc cccgcaaact ccccttcccg gccaccttgg      480

tcgcgtccgc gccgccgccg gcccagccgg accgcaccac gcgaggcgcg agataggggg      540

gcacgggcgc gaccatctgc gctgcggcgc cggcgactca gcgctgcctc agtctgcggt      600

gggcagcgga ggagtcgtgt cgtgcctgag agcgcagcaa gtttgtacaa aaaagcaggc      660

tgccaccatg catcaccaac agcgaatggc tgccttaggg acggacaaag agctgagtga      720

tttactggat ttcagtgcga tgttttcacc tcctgtgagc agtgggaaaa atggaccaac      780

ttctttggca agtggacatt ttactggctc aaatgtagaa gacagaagta gctcagggtc      840

ctgggggaat ggaggacatc caagcccgtc caggaactat ggagatggga ctccctatga      900

ccacatgacc agcagggacc ttgggtcaca tgacaatctc tctccacctt ttgtcaattc      960

cagaatacaa agtaaaacag aaaggggctc atactcatct tatgggagag aatcaaactt     1020

acagggttgc caccagcaga gtctccttgg aggtgacatg gatatgggca acccaggaac     1080

cctttcgccc accaaacctg gttcccagta ctatcagtat tctagcaata atccccgaag     1140

gaggcctctt cacagtagtg ccatggaggt acagacaaag aaagttcgaa aagttcctcc     1200

aggtttgcca tcttcagtct atgctccatc agcaagcact gccgactaca atagggactc     1260

gccaggctat ccttcctcca aaccagcaac cagcactttc cctagctcct tcttcatgca     1320

agatggccat cacagcagtg acccttggag ctcctccagt gggatgaatc agcctggcta     1380

tgcaggaatg ttgggcaact cttctcatat tccacagtcc agcagctact gtagcctgca     1440

tccacatgaa cgtttgagct atccatcaca ctcctcagca gacatcaatt ccagtcttcc     1500

tccgatgtcc actttccatc gtagtggtac aaaccattac agcacctctt cctgtacgcc     1560

tcctgccaac gggacagaca gtataatggc aaatagagga agcggggcag ccggcagctc     1620

ccagactgga gatgctctgg ggaaagcact tgcttcgatc tattctccag atcacactaa     1680

caacagcttt tcatcaaacc cttcaactcc tgttggctct cctccatctc tctcagcagg     1740

cacagctgtt tggtctagaa atggaggaca ggcctcatcg tctcctaatt atgaaggacc     1800

cttacactct ttgcaaagcc gaattgaaga tcgtttagaa agactggatg atgctattca     1860

tgttctccgg aaccatgcag tgggcccatc cacagctatg cctggtggtc atggggacat     1920

gcatggaatc attggacctt ctcataatgg agccatgggt ggtctgggct cagggtatgg     1980

aaccggcctt ctttcagcca acagacattc actcatggtg gggacccatc gtgaagatgg     2040

cgtggccctg agaggcagcc attctcttct gccaaaccag gttccggttc cacagcttcc     2100

tgtccagtct gcgacttccc ctgacctgaa cccaccccag gacccttaca gaggcatgcc     2160

accaggacta caggggcaga gtgtctcctc tggcagctct gagatcaaat ccgatgacga     2220

gggtgatgag aacctgcaag acacgaaatc ttcggaggac aagaaattag atgacgacaa     2280

gaaggatatc aaatcaatta ctaggtcaag atctagcaat aatgacgatg aggacctgac     2340

accagagcag aaggcagagc gtgagaagga gcggaggatg gccaacaatg cccgagagcg     2400

tctgcgggtc cgtgacatca acgaggcttt caaagagctc ggccgcatgg tgcagctcca     2460

cctcaagagt gacaagcccc agaccaagct cctgatcctc caccaggcgg tggccgtcat     2520

cctcagtctg gagcagcaag tccgagaaag gaatctgaat ccgaaagctg cgtgtctgaa     2580

aagaagggag gaagagaagg tgtcctcaga gcctccccct ctctccttgg ccggcccaca     2640

ccctggaatg ggagacgcat cgaatcacat gggacagatg taaacccagc tttcttgtac     2700

aaagtgggaa ttccgataat caacctctgg attacaaaat ttgtgaaaga ttgactggta     2760

ttcttaacta tgttgctcct tttacgctat gtggatacgc tgctttaatg cctttgtatc     2820

atgctattgc ttcccgtatg gctttcattt tctcctcctt gtataaatcc tggttgctgt     2880

ctctttatga ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg     2940

ctgacgcaac ccccactggt tggggcattg ccaccacctg tcagctcctt tccgggactt     3000

tcgctttccc cctccctatt gccacggcgg aactcatcgc cgcctgcctt gcccgctgct     3060

ggacaggggc tcggctgttg ggcactgaca attccgtggt gttgtcgggg aagctgacgt     3120

cctttccatg gctgctcgcc tgtgttgcca cctggattct gcgcgggacg tccttctgct     3180

acgtcccttc ggccctcaat ccagcggacc ttccttcccg cggcctgctg ccggctctgc     3240

ggcctcttcc gcgtcttcgc cttcgccctc agacgagtcg gatctccctt tgggccgcct     3300

ccccgcatcg ggaattccta gagctcgctg atcagcctcg actgtgcctt ctagttgcca     3360

gccatctgtt gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg ccactcccac     3420

tgtcctttcc taataaaatg aggaaattgc atcgcattgt ctgagtaggt gtcattctat     3480

tctggggggt ggggtggggc aggacagcaa gggggaggat tgggaagaga atagcaggca     3540

tgctggggag ggccgcagga acccctagtg atggagttgg ccactccctc tctgcgcgct     3600

cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg     3660

gcctcagtga gcgagcgagc gcgcagctgc ctgcaggggc gcctgatgcg gtattttctc     3720

cttacgcatc tgtgcggtat ttcacaccgc atacgtcaaa gcaaccatag tacgcgccct     3780

gtagcggcgc attaagcgcg gcgggggtgg tggttacgcg cagcgtgacc gctacacttg     3840

ccagcgcctt agcgcccgct cctttcgctt tcttcccttc ctttctcgcc acgttcgccg     3900

gctttccccg tcaagctcta aatcgggggc tccctttagg gttccgattt agtgctttac     3960

ggcacctcga ccccaaaaaa cttgatttgg gtgatggttc acgtagtggg ccatcgccct     4020

gatagacggt ttttcgccct ttgacgttgg agtccacgtt ctttaatagt ggactcttgt     4080

tccaaactgg aacaacactc aactctatct cgggctattc ttttgattta taagggattt     4140

tgccgatttc ggtctattgg ttaaaaaatg agctgattta acaaaaattt aacgcgaatt     4200

ttaacaaaat attaacgttt acaattttat ggtgcactct cagtacaatc tgctctgatg     4260

ccgcatagtt aagccagccc cgacacccgc caacacccgc tgacgcgccc tgacgggctt     4320

gtctgctccc ggcatccgct tacagacaag ctgtgaccgt ctccgggagc tgcatgtgtc     4380

agaggttttc accgtcatca ccgaaacgcg cgagacgaaa gggcctcgtg atacgcctat     4440

ttttataggt taatgtcatg ataataatgg tttcttagac gtcaggtggc acttttcggg     4500

gaaatgtgcg cggaacccct atttgtttat ttttctaaat acattcaaat atgtatccgc     4560

tcatgagaca ataaccctga taaatgcttc aataatattg aaaaaggaag agtatgagta     4620

ttcaacattt ccgtgtcgcc cttattccct tttttgcggc attttgcctt cctgtttttg     4680

ctcacccaga aacgctggtg aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg     4740

gttacatcga actggatctc aacagcggta agatccttga gagttttcgc cccgaagaac     4800

gttttccaat gatgagcact tttaaagttc tgctatgtgg cgcggtatta tcccgtattg     4860

acgccgggca agagcaactc ggtcgccgca tacactattc tcagaatgac ttggttgagt     4920

actcaccagt cacagaaaag catcttacgg atggcatgac agtaagagaa ttatgcagtg     4980

ctgccataac catgagtgat aacactgcgg ccaacttact tctgacaacg atcggaggac     5040

cgaaggagct aaccgctttt ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt     5100

gggaaccgga gctgaatgaa gccataccaa acgacgagcg tgacaccacg atgcctgtag     5160

caatggcaac aacgttgcgc aaactattaa ctggcgaact acttactcta gcttcccggc     5220

aacaattaat agactggatg gaggcggata aagttgcagg accacttctg cgctcggccc     5280

ttccggctgg ctggtttatt gctgataaat ctggagccgg tgagcgtgga agccgcggta     5340

tcattgcagc actggggcca gatggtaagc cctcccgtat cgtagttatc tacacgacgg     5400

ggagtcaggc aactatggat gaacgaaata gacagatcgc tgagataggt gcctcactga     5460

ttaagcattg gtaactgtca gaccaagttt actcatatat actttagatt gatttaaaac     5520

ttcattttta atttaaaagg atctaggtga agatcctttt tgataatctc atgaccaaaa     5580

tcccttaacg tgagttttcg ttccactgag cgtcagaccc cgtagaaaag atcaaaggat     5640

cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc     5700

taccagcggt ggtttgtttg ccggatcaag agctaccaac tctttttccg aaggtaactg     5760

gcttcagcag agcgcagata ccaaatactg ttcttctagt gtagccgtag ttaggccacc     5820

acttcaagaa ctctgtagca ccgcctacat acctcgctct gctaatcctg ttaccagtgg     5880

ctgctgccag tggcgataag tcgtgtctta ccgggttgga ctcaagacga tagttaccgg     5940

ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac acagcccagc ttggagcgaa     6000

cgacctacac cgaactgaga tacctacagc gtgagctatg agaaagcgcc acgcttcccg     6060

aagggagaaa ggcggacagg tatccggtaa gcggcagggt cggaacagga gagcgcacga     6120

gggagcttcc agggggaaac gcctggtatc tttatagtcc tgtcgggttt cgccacctct     6180

gacttgagcg tcgatttttg tgatgctcgt caggggggcg gagcctatgg aaaaacgcca     6240

gcaacgcggc ctttttacgg ttcctggcct tttgctggcc ttttgctcac atgt           6294


<210>  10
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  microE5 box

<400>  10
cacctgcaag aa                                                           12


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA Sequence

<400>  11
ctttataagc ccgcagttcc                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  12
ccgcagttcc cggatgtgaa                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  13
gtcgaccagc accgccatct                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  14
ggtaaacaga gcgcctagag                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  15
cattcacatc cgggaactgc                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  16
acataggaag gtacgacttc                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA Sequence

<400>  17
tttacgtacc agacatagga                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  18
ttcctttacg taccagacat                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  19
ttcctatgtc tggtacgtaa                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  20
aagtcgtacc ttcctatgtc                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  21
cacgcttggc ccggccatat                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  22
ctttgcatat tcaccacgct                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  23
agcgtctgac agcagcgccg                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  24
tcaactttgc gcagcggagc                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  25
agacgctcaa ctttgcgcag                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence - scramble

<400>  26
aaatgtgaga tcagagtaat                                                   20


<210>  27
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCF4 3b Forward Primer

<400>  27
gtgccgaaac tacacttttg tg                                                22


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCF4 3b Reverse Primer

<400>  28
acaagattat gcacctggct                                                   20


<210>  29
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCF4 8a Forward Primer

<400>  29
tggaaagggg atgcttactc tc                                                22


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCF4 8a Reverse Primer

<400>  30
aactctaatg acctccgcct                                                   20


<210>  31
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCF4 10a Forward Primer

<400>  31
ttaccctaag gcagttgagt gga                                               23


<210>  32
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCF4 10a Reverse Primer

<400>  32
ttgtcaaaaa tccccctcgc a                                                 21


<210>  33
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCF4 4/5 Forward Primer

<400>  33
cctcctgtga gcagtggga                                                    19


<210>  34
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCF4 4/5 Reverse Primer

<400>  34
ctggacgggc ttggatgtc                                                    19


<210>  35
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCF4 9/10 Forward Primer

<400>  35
gccatcttca gtctatgctc catc                                              24


<210>  36
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCF4 9/10 Reverse Primer

<400>  36
tagggaaagt gctggttgct gg                                                22


<210>  37
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCF4-A Forward Primer

<400>  37
ggaaagcggt ctatgctcca t                                                 21


<210>  38
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCF4-A Reverse Primer

<400>  38
tagggaaagt gctggttgct gg                                                22


<210>  39
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCF4 12/13 Forward Primer

<400>  39
cttcctccga tgtccacttt cca                                               23


<210>  40
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCF4 12/13 Reverse Primer

<400>  40
cccgcttcct ctatttgcca t                                                 21


<210>  41
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MPH Forward Primer

<400>  41
atcagggcgt gtccatgtct ca                                                22


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MPH Reverse Primer

<400>  42
cgggtaatgg cttcggggta                                                   20


<210>  43
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  dCAS9 Forward Primer

<400>  43
gccgacgcta atctggacaa agt                                               23


<210>  44
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  dCas9 Reverse Primer

<400>  44
tggtcagggt aaacaggtgg atg                                               23


<210>  45
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TBP Forward Primer

<400>  45
tgtatccaca gtgaatcttg gttg                                              24


<210>  46
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TBP Reverse Primer

<400>  46
ggttcgtggc tctcttatcc tc                                                22


<210>  47
<211>  23
<212>  DNA
<213>  Artificial Sequencd

<220>
<223>  CNTNAP2 Forward Primer

<400>  47
tcacacagac caagatgagc caa                                               23


<210>  48
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CNTNAP2 Reverse Primer

<400>  48
taggaagcga acctcgtgcc a                                                 21


<210>  49
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KCNQ1 Forward Primer

<400>  49
ggacaaagac aatggggtga ct                                                22


<210>  50
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KCNQ1 Reverse Primer

<400>  50
gtgttgggct cttccttaca gaa                                               23


<210>  51
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCF4B cDNA Forward Primer

<400>  51
atgcatcacc aacagcgaat gg                                                22


<210>  52
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCF4B cDNA Reverse Primer

<400>  52
atcctcgagt tacatctgtc ccatgtgatt cg                                     32


<210>  53
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  minP TCF4

<400>  53
gaattcagag ggtatataat ggaagctcga cttccagatg catcaccaac agcgaatgg        59


<210>  54
<211>  131
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E-box-x6-minP TCF4

<400>  54
gaattcaaca cctgcaagaa cacctgcaag aacacctgca agaacacctg caagaacacc       60

tgcaagaaca cctgcaagag agggtatata atggaagctc gacttccaga tgcatcacca      120

acagcgaatg g                                                           131


<210>  55
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E-box-x12-MinP TCF4

<400>  55
gaattcacct gcaagaacac ctgcaagaac acctgcaaga acacctgcaa gaacacctgc       60

aagaacacct gcaagaacac ctgcaagaac acctgcaaga acacctgcaa gaacacctgc      120

aagaacacct gcaagaacac ctgcaagaga gggtatataa tggaagctcg acttccagat      180

gcatcaccaa cagcgaatgg                                                  200


