                         SEQUENCE LISTING

<110>  Zoetis Services LLC
 
<120>  FELINE ANTIBODY VARIANTS

<130>  ZP000359A

<150>  63/084,693
<151>  2020-09-29

<160>  138   

<170>  PatentIn version 3.5


<210>  1
<211>  335
<212>  PRT
<213>  Felis catus

<400>  1

Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly 
1               5                   10                  15      


Thr Thr Ser Gly Ala Thr Val Ala Leu Ala Cys Leu Val Leu Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ala Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Leu Ser Asp Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Ala His Pro Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Arg Lys Thr Asp His Pro Pro Gly Pro Lys Pro Cys Asp Cys 
            100                 105                 110         


Pro Lys Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile 
        115                 120                 125             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu 
    130                 135                 140                 


Val Thr Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln 
145                 150                 155                 160 


Ile Thr Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser 
                165                 170                 175     


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            180                 185                 190         


Pro Ile Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys 
        195                 200                 205             


Val Asn Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys 
    210                 215                 220                 


Ala Lys Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala 
225                 230                 235                 240 


Gln Glu Glu Leu Ser Arg Asn Lys Val Ser Val Thr Cys Leu Ile Lys 
                245                 250                 255     


Ser Phe His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln 
            260                 265                 270         


Pro Glu Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser 
        275                 280                 285             


Asp Gly Thr Tyr Phe Val Tyr Ser Lys Leu Ser Val Asp Arg Ser His 
    290                 295                 300                 


Trp Gln Arg Gly Asn Thr Tyr Thr Cys Ser Val Leu His Glu Ala Leu 
305                 310                 315                 320 


His Ser His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
                325                 330                 335 


<210>  2
<211>  335
<212>  PRT
<213>  Felis catus

<400>  2

Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly 
1               5                   10                  15      


Thr Thr Ser Gly Ala Thr Val Ala Leu Ala Cys Leu Val Leu Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ala Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Leu Ser Asp Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Ala His Pro Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Arg Lys Thr Asp His Pro Pro Gly Pro Lys Pro Cys Asp Cys 
            100                 105                 110         


Pro Lys Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile 
        115                 120                 125             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu 
    130                 135                 140                 


Val Thr Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln 
145                 150                 155                 160 


Ile Thr Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser 
                165                 170                 175     


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            180                 185                 190         


Pro Ile Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys 
        195                 200                 205             


Val Asn Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys 
    210                 215                 220                 


Ala Lys Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala 
225                 230                 235                 240 


Gln Glu Glu Leu Ser Arg Asn Lys Val Ser Val Thr Cys Leu Ile Lys 
                245                 250                 255     


Ser Phe His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln 
            260                 265                 270         


Pro Glu Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser 
        275                 280                 285             


Asp Gly Thr Tyr Phe Val Tyr Ser Lys Leu Ser Val Asp Arg Ser His 
    290                 295                 300                 


Trp Gln Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu 
305                 310                 315                 320 


His His His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
                325                 330                 335 


<210>  3
<211>  335
<212>  PRT
<213>  Felis catus

<400>  3

Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly 
1               5                   10                  15      


Thr Thr Ser Gly Ala Thr Val Ala Leu Ala Cys Leu Val Leu Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ala Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Leu Ser Asp Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Ala His Pro Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Arg Lys Thr Asp His Pro Pro Gly Pro Lys Pro Cys Asp Cys 
            100                 105                 110         


Pro Lys Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile 
        115                 120                 125             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu 
    130                 135                 140                 


Val Thr Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln 
145                 150                 155                 160 


Ile Thr Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser 
                165                 170                 175     


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            180                 185                 190         


Pro Ile Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys 
        195                 200                 205             


Val Asn Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys 
    210                 215                 220                 


Ala Lys Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala 
225                 230                 235                 240 


Gln Glu Glu Leu Ser Arg Asn Lys Val Ser Val Thr Cys Leu Ile Lys 
                245                 250                 255     


Ser Phe His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln 
            260                 265                 270         


Pro Glu Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser 
        275                 280                 285             


Asp Gly Thr Tyr Phe Val Tyr Ser Lys Leu Ser Val Asp Arg Ser His 
    290                 295                 300                 


Trp Gln Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu 
305                 310                 315                 320 


His Ser His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
                325                 330                 335 


<210>  4
<211>  1005
<212>  DNA
<213>  Felis catus

<400>  4
gcctccacca cggccccatc ggtgttccca ctggccccca gctgcgggac cacatctggc       60

gccaccgtgg ccctggcctg cctggtgtta ggctacttcc ctgagccggt gaccgtgtcc      120

tggaactccg gcgccctgac cagcggtgtg cacaccttcc cggccgtcct gcaggcctcg      180

gggctgtact ctctcagcag catggtgaca gtgccctcca gcaggtggct cagtgacacc      240

ttcacctgca acgtggccca cccgcccagc aacaccaagg tggacaagac cgtgcgcaaa      300

acagaccacc caccgggacc caaaccctgc gactgtccca aatgcccacc ccctgagatg      360

cttggaggac cgtccatctt catcttcccc ccaaaaccca aggacaccct ctcgatttcc      420

cggacgcccg aggtcacatg cttggtggtg gacttgggcc cagatgactc cgatgtccag      480

atcacatggt ttgtggataa cacccaggtg tacacagcca agacgagtcc gcgtgaggag      540

cagttcaaca gcacctaccg tgtggtcagt gtcctcccca tcctacacca ggactggctc      600

aaggggaagg agttcaagtg caaggtcaac agcaaatccc tcccctcccc catcgagagg      660

accatctcca aggccaaagg acagccccac gagccccagg tgtacgtcct gcctccagcc      720

caggaggagc tcagcaggaa caaagtcagt gtgacctgcc tgatcaaatc cttccacccg      780

cctgacattg ccgtcgagtg ggagatcacc ggacagccgg agccagagaa caactaccgg      840

acgaccccgc cccagctgga cagcgacggg acctacttcg tgtacagcaa gctctcggtg      900

gacaggtccc actggcagag gggaaacacc tacacctgct cggtgtcaca cgaagctctg      960

cacagccacc acacacagaa atccctcacc cagtctccgg gtaaa                     1005


<210>  5
<211>  98
<212>  PRT
<213>  Felis catus

<400>  5

Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly 
1               5                   10                  15      


Thr Thr Ser Gly Ala Thr Val Ala Leu Ala Cys Leu Val Leu Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ala Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Leu Ser Asp Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Ala His Pro Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val 
        


<210>  6
<211>  18
<212>  PRT
<213>  Felis catus

<400>  6

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Pro Cys Asp Cys Pro Lys 
1               5                   10                  15      


Cys Pro 
        


<210>  7
<211>  110
<212>  PRT
<213>  Felis catus

<400>  7

Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr Cys Leu 
            20                  25                  30          


Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr Trp Phe 
        35                  40                  45              


Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg Glu Glu 
    50                  55                  60                  


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn Ser Lys 
                85                  90                  95      


Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  8
<211>  109
<212>  PRT
<213>  Felis catus

<400>  8

Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu 
1               5                   10                  15      


Glu Leu Ser Arg Asn Lys Val Ser Val Thr Cys Leu Ile Lys Ser Phe 
            20                  25                  30          


His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
        35                  40                  45              


Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
    50                  55                  60                  


Thr Tyr Phe Val Tyr Ser Lys Leu Ser Val Asp Arg Ser His Trp Gln 
65                  70                  75                  80  


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
                85                  90                  95      


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
            100                 105                 


<210>  9
<211>  294
<212>  DNA
<213>  Felis catus

<400>  9
gcctccacca cggccccatc ggtgttccca ctggccccca gctgcgggac cacatctggc       60

gccaccgtgg ccctggcctg cctggtgtta ggctacttcc ctgagccggt gaccgtgtcc      120

tggaactccg gcgccctgac cagcggtgtg cacaccttcc cggccgtcct gcaggcctcg      180

gggctgtact ctctcagcag catggtgaca gtgccctcca gcaggtggct cagtgacacc      240

ttcacctgca acgtggccca cccgcccagc aacaccaagg tggacaagac cgtg            294


<210>  10
<211>  54
<212>  DNA
<213>  Felis catus

<400>  10
cgcaaaacag accacccacc gggacccaaa ccctgcgact gtcccaaatg ccca             54


<210>  11
<211>  330
<212>  DNA
<213>  Felis catus

<400>  11
ccccctgaga tgcttggagg accgtccatc ttcatcttcc ccccaaaacc caaggacacc       60

ctctcgattt cccggacgcc cgaggtcaca tgcttggtgg tggacttggg cccagatgac      120

tccgatgtcc agatcacatg gtttgtggat aacacccagg tgtacacagc caagacgagt      180

ccgcgtgagg agcagttcaa cagcacctac cgtgtggtca gtgtcctccc catcctacac      240

caggactggc tcaaggggaa ggagttcaag tgcaaggtca acagcaaatc cctcccctcc      300

cccatcgaga ggaccatctc caaggccaaa                                       330


<210>  12
<211>  327
<212>  DNA
<213>  Felis catus

<400>  12
ggacagcccc acgagcccca ggtgtacgtc ctgcctccag cccaggagga gctcagcagg       60

aacaaagtca gtgtgacctg cctgatcaaa tccttccacc cgcctgacat tgccgtcgag      120

tgggagatca ccggacagcc ggagccagag aacaactacc ggacgacccc gccccagctg      180

gacagcgacg ggacctactt cgtgtacagc aagctctcgg tggacaggtc ccactggcag      240

aggggaaaca cctacacctg ctcggtgtca cacgaagctc tgcacagcca ccacacacag      300

aaatccctca cccagtctcc gggtaaa                                          327


<210>  13
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZTS-5864 Heavy Chain Variable Region

<400>  13
gacgtgcaat tggtggagtc tgggggagac ctggtgaagc ctggggggtc cctgagactc       60

acctgtgtgg cctctggatt caccttcagt gactatgcaa tgagctgggt ccgccaggct      120

ccagggaagg ggctgcagtg ggtcgcaggt attgacagtg ttggaagtgg cacaagctac      180

gcagactccg tgaagggccg attcaccatc tccagagaca atgccaagaa cacgctgtat      240

ctgcagatga acagcctcaa gaccgaggac acggccacat attactgtgc gagcgggttc      300

cctgggtcct ttgagcactg gggccaagga accctggtga cggtctcgag c               351


<210>  14
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZTS-5864 Heavy Chain Variable Region

<400>  14

Asp Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Val Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ala Gly Ile Asp Ser Val Gly Ser Gly Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gly Phe Pro Gly Ser Phe Glu His Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  15
<211>  5
<212>  PRT
<213>  Canis familiaris

<400>  15

Asp Tyr Ala Met Ser 
1               5   


<210>  16
<211>  17
<212>  PRT
<213>  Canis familiaris

<400>  16

Gly Ile Asp Ser Val Gly Ser Gly Thr Ser Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  17
<211>  8
<212>  PRT
<213>  Canis familiaris

<400>  17

Gly Phe Pro Gly Ser Phe Glu His 
1               5               


<210>  18
<211>  312
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZTS-5864 Light Chain Variable Region

<400>  18
cagtctgtgc tgactcagcc atcctcagtg tctgggaccc taggccagag gatcaccatc       60

tcctgcaccg gaagcagctc caacatcggg agtggttatg tgggctggta tcaacaagtc      120

ccaggaatgg gccccaaaac cgtcatctat tataatagcg accgaccctc tggagtccca      180

gataggttct ccggctccaa gtctggcagc tcaggcaccc tgaccatcac tggattgcag      240

gctgaagacg aggctgacta ttactgttca gtatatgaca gaactttcaa tgctgtgttc      300

ggcggaggga cc                                                          312


<210>  19
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZTS-5864 Light Chain Variable Region

<400>  19

Gln Ser Val Leu Thr Gln Pro Ser Ser Val Ser Gly Thr Leu Gly Gln 
1               5                   10                  15      


Arg Ile Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ser Gly 
            20                  25                  30          


Tyr Val Gly Trp Tyr Gln Gln Val Pro Gly Met Gly Pro Lys Thr Val 
        35                  40                  45              


Ile Tyr Tyr Asn Ser Asp Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Ser Ser Gly Thr Leu Thr Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Val Tyr Asp Arg Thr Phe 
                85                  90                  95      


Asn Ala Val Phe Gly Gly Gly Thr 
            100                 


<210>  20
<211>  13
<212>  PRT
<213>  Canis familiaris

<400>  20

Thr Gly Ser Ser Ser Asn Ile Gly Ser Gly Tyr Val Gly 
1               5                   10              


<210>  21
<211>  7
<212>  PRT
<213>  Canis familiaris

<400>  21

Tyr Tyr Asn Ser Asp Arg Pro 
1               5           


<210>  22
<211>  10
<212>  PRT
<213>  Canis familiaris

<400>  22

Ser Val Tyr Asp Arg Thr Phe Asn Ala Val 
1               5                   10  


<210>  23
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZTS768_Heavy_chain

<400>  23

Asp Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Val Ala Ser Gly Phe Thr Tyr Ser Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ala Arg Ile Asp Pro Tyr Gly Gly Gly Thr Lys His Asn Glu Lys Phe 
    50                  55                  60                  


Lys Arg Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Arg Ser Gly Tyr Asp Tyr Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Cys Gly Thr Thr Ser Gly Ala Thr Val Ala Leu Ala 
    130                 135                 140                 


Cys Leu Val Leu Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ala Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser 
            180                 185                 190         


Arg Trp Leu Ser Asp Thr Phe Thr Cys Asn Val Ala His Pro Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Thr Val Arg Lys Thr Asp His Pro Pro Gly 
    210                 215                 220                 


Pro Lys Pro Cys Asp Cys Pro Lys Cys Pro Pro Pro Glu Met Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Ile Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Ser 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Leu Val Val Asp Leu Gly Pro 
            260                 265                 270         


Asp Asp Ser Asp Val Gln Ile Thr Trp Phe Val Asp Asn Thr Gln Val 
        275                 280                 285             


Tyr Thr Ala Lys Thr Ser Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Pro Ile Leu His Gln Asp Trp Leu Lys Gly 
305                 310                 315                 320 


Lys Glu Phe Lys Cys Lys Val Asn Ser Lys Ser Leu Pro Ser Pro Ile 
                325                 330                 335     


Glu Arg Thr Ile Ser Lys Ala Lys Gly Gln Pro His Glu Pro Gln Val 
            340                 345                 350         


Tyr Val Leu Pro Pro Ala Gln Glu Glu Leu Ser Arg Asn Lys Val Ser 
        355                 360                 365             


Val Thr Cys Leu Ile Lys Ser Phe His Pro Pro Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ile Thr Gly Gln Pro Glu Pro Glu Asn Asn Tyr Arg Thr Thr 
385                 390                 395                 400 


Pro Pro Gln Leu Asp Ser Asp Gly Thr Tyr Phe Val Tyr Ser Lys Leu 
                405                 410                 415     


Ser Val Asp Arg Ser His Trp Gln Arg Gly Asn Thr Tyr Thr Cys Ser 
            420                 425                 430         


Val Ser His Glu Ala Leu His Ser His His Thr Gln Lys Ser Leu Thr 
        435                 440                 445             


Gln Ser Pro Gly Lys 
    450             


<210>  24
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  24

Asn Tyr Trp Met His 
1               5   


<210>  25
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  25

Arg Ile Asp Pro Tyr Gly Gly Gly Thr Lys His Asn Glu Lys Phe Lys 
1               5                   10                  15      


Arg 
    


<210>  26
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  26

Ser Gly Tyr Asp Tyr Tyr Phe Asp Val 
1               5                   


<210>  27
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZTS768_Light_chain

<400>  27

Glu Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Phe 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His His Phe Gly Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Ser Asp Ala Gln 
            100                 105                 110         


Pro Ser Val Phe Leu Phe Gln Pro Ser Leu Asp Glu Leu His Thr Gly 
        115                 120                 125             


Ser Ala Ser Ile Val Cys Ile Leu Asn Asp Phe Tyr Pro Lys Glu Val 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Val Gln Asn Lys Gly Ile Gln 
145                 150                 155                 160 


Glu Ser Thr Thr Glu Gln Asn Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Gln Ser His Glu Lys Phe 
            180                 185                 190         


Ser Cys Glu Val Thr His Lys Ser Leu Ala Ser Thr Leu Val Lys Ser 
        195                 200                 205             


Phe Gln Arg Ser Glu Cys Gln Arg Glu 
    210                 215         


<210>  28
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  28

Arg Ala Ser Glu Asn Ile Tyr Ser Phe Leu Ala 
1               5                   10      


<210>  29
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  29

Asn Ala Asn Thr Leu Ala Glu 
1               5           


<210>  30
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  30

Gln His His Phe Gly Thr Pro Phe Thr 
1               5                   


<210>  31
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NV02_Heavy chain

<400>  31

Gln Val Gln Leu Val Glu Ser Gly Ala Glu Leu Val Gln Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Phe Ser Leu Thr Asn Asn 
            20                  25                  30          


Asn Val Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Val Trp Ala Gly Gly Ala Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Thr Arg Asp Thr Ser Lys Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met His Ser Leu Gln Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Gly Tyr Ser Ser Ser Thr Leu Tyr Ala Met Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ala Ala Ser Thr Thr Ala Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Thr Thr Ser Gly Ala Thr 
    130                 135                 140                 


Val Ala Leu Ala Cys Leu Val Leu Gly Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ala Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr 
            180                 185                 190         


Val Pro Ser Ser Arg Trp Leu Ser Asp Thr Phe Thr Cys Asn Val Ala 
        195                 200                 205             


His Pro Pro Ser Asn Thr Lys Val Asp Lys Thr Val Arg Lys Thr Asp 
    210                 215                 220                 


His Pro Pro Gly Pro Lys Pro Cys Asp Cys Pro Lys Cys Pro Pro Pro 
225                 230                 235                 240 


Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr Cys Leu Val Val 
            260                 265                 270         


Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr Trp Phe Val Asp 
        275                 280                 285             


Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn Ser Lys Ser Leu 
                325                 330                 335     


Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Lys Gly Gln Pro His 
            340                 345                 350         


Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu Glu Leu Ser Arg 
        355                 360                 365             


Asn Lys Val Ser Val Thr Cys Leu Ile Lys Ser Phe His Pro Pro Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly Thr Tyr Phe Val 
                405                 410                 415     


Tyr Ser Lys Leu Ser Val Asp Arg Ser His Trp Gln Arg Gly Asn Thr 
            420                 425                 430         


Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser His His Thr Gln 
        435                 440                 445             


Lys Ser Leu Thr Gln Ser Pro Gly Lys 
    450                 455         


<210>  32
<211>  10
<212>  PRT
<213>  Rattus rattus

<400>  32

Gly Phe Ser Leu Thr Asn Asn Asn Val Asn 
1               5                   10  


<210>  33
<211>  16
<212>  PRT
<213>  Rattus rattus

<400>  33

Gly Val Trp Ala Gly Gly Ala Thr Asp Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  34
<211>  14
<212>  PRT
<213>  Rattus rattus

<400>  34

Asp Gly Gly Tyr Ser Ser Ser Thr Leu Tyr Ala Met Asp Ala 
1               5                   10                  


<210>  35
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >NV02_Kappa chain

<400>  35

Asp Ile Glu Met Thr Gln Ser Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ala Ser Glu Asp Ile Tyr Asn Ala 
            20                  25                  30          


Leu Ala Trp Tyr Leu Gln Lys Pro Gly Arg Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asn Thr Asp Thr Leu His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Gln Thr 
65                  70                  75                  80  


Glu Asp Val Gly Val Tyr Phe Cys Gln His Tyr Phe His Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu Lys Arg Ser Asp Ala Gln 
            100                 105                 110         


Pro Ser Val Phe Leu Phe Gln Pro Ser Leu Asp Glu Leu His Thr Gly 
        115                 120                 125             


Ser Ala Ser Ile Val Cys Ile Leu Asn Asp Phe Tyr Pro Lys Glu Val 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Val Gln Asn Lys Gly Ile Gln 
145                 150                 155                 160 


Glu Ser Thr Thr Glu Gln Asn Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Gln Ser His Glu Lys Phe 
            180                 185                 190         


Ser Cys Glu Val Thr His Lys Ser Leu Ala Ser Thr Leu Val Lys Ser 
        195                 200                 205             


Phe Gln Arg Ser Glu Cys Gln Arg Glu 
    210                 215         


<210>  36
<211>  11
<212>  PRT
<213>  Rattus rattus

<400>  36

Arg Ala Ser Glu Asp Ile Tyr Asn Ala Leu Ala 
1               5                   10      


<210>  37
<211>  7
<212>  PRT
<213>  Rattus rattus

<400>  37

Asn Thr Asp Thr Leu His Thr 
1               5           


<210>  38
<211>  9
<212>  PRT
<213>  Rattus rattus

<400>  38

Gln His Tyr Phe His Tyr Pro Arg Thr 
1               5                   



<210>  39
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  39

Ser Ser Trp Met Asn 
1               5   


<210>  40
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  40

Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  41
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  41

Ala Arg His Tyr Asp Gly Ser Thr Asp Tyr 
1               5                   10  



<210>  42
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  42

Arg Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala  
1               5                   10                 



<210>  43
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  43

Ala Ala Thr Asn Leu Ala Asp 
1               5           


<210>  44
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  44

Gln His Phe Trp Gly Thr Pro Tyr Thr 
1               5                   


<210>  45
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Heavy Region Engineered to Have 
       Sequences from Mus musculus and Felis

<400>  45

Gln Val Leu Leu Val Gln Ser Gly Ala Glu Val Arg Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Phe Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Ser 
            20                  25                  30          


Trp Met Asn Trp Leu Arg Gln Ala Pro Ala Gln Gly Phe Glu Trp Met 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Leu Thr Leu Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Tyr Asp Gly Ser Thr Asp Tyr Trp Gly His Gly Thr Ile 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  46
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Heavy Region Engineered to Have 
       Sequences from Mus musculus and Felis

<400>  46
caggtgctgc tggtgcagag cggcgcggaa gtgcgccgcc cgggcgcgag cgtgaaaatt       60

ttttgcaaag cgagcggcta tagctttacc agcagctgga tgaactggct gcgccaggcg      120

ccggcgcagg gctttgaatg gatgggccag atttatccgg gcgatggcga taccaactat      180

aacggcaaat ttaaaggccg cctgaccctg accgcggata ccagcaccga taccgcgtat      240

atggaactga gcagcctgcg cagcgcggat accgcggtgt attattgcgc gcgccattat      300

gatggcagca ccgattattg gggccatggc accattgtga ccgtgagcag c               351


<210>  47
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Light Region Engineered to Have 
       Sequences from Mus musculus and Felis

<400>  47

Ala Ile Thr Met Thr Gln Ser Pro Gly Ser Leu Ala Gly Ser Pro Gly 
1               5                   10                  15      


Gln Gln Val Thr Met Asn Cys Arg Ala Ser Glu Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln His Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Ser Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys 
            100             


<210>  48
<211>  309
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Light Region Engineered to Have 
       Sequences from Mus musculus and Felis

<400>  48
gcgattacca tgacccagag cccgggcagc ctggcgggca gcccgggcca gcaggtgacc       60

atgaactgcc gcgcgagcga aaacatttat agcaacctgg cgtggtatca gcagaaaccg      120

ggccagcatc cgaaactgct gatttatgcg gcgaccaacc tggcggatgg cgtgccggat      180

cgctttagcg gcagcggcag cggcaccgat tttaccctga ccattagcaa cctgcaggcg      240

gaagatgtgg cgagctatta ttgccagcat ttttggggca ccccgtatac ctttggcggc      300

ggcaccaaa                                                              309


<210>  49
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  49

Ser Asn Val Ile Ser 
1               5   


<210>  50
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  50

Gly Val Ile Pro Ile Val Asp Ile Ala Asn Tyr Ala Gln Arg Phe Lys 
1               5                   10                  15      


Gly Arg 
        


<210>  51
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  51

Thr Leu Gly Leu Val Leu Asp Ala Met Asp Tyr 
1               5                   10      


<210>  52
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  52

Arg Ala Ser Gln Ser Leu Gly Ser Ser Tyr 
1               5                   10  


<210>  53
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  53

Gly Ala Ser Ser Arg Ala Pro 
1               5           


<210>  54
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  54

Gln Gln Tyr Ala Asp Ser Pro Ile Thr 
1               5                   


<210>  55
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Heavy Region Engineered to Have 
       Sequences from Homo sapiens and Felis

<400>  55

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Asn 
            20                  25                  30          


Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Val Ile Pro Ile Val Asp Ile Ala Asn Tyr Ala Gln Arg Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Thr Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Leu Gly Leu Val Leu Asp Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  56
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Heavy Region Engineered to Have 
       Sequences from Homo sapiens and Felis

<400>  56
caggtgcagc tggtgcagtc cggagctgag gtgaagaagc caggctccag cgtgaaggtg       60

tcttgcaagg cttccggcta caccttctct tccaacgtga tcagctgggt gagacaggct      120

ccaggacagg gactggagtg gatgggaggc gtgatcccta tcgtggacat cgccaattac      180

gctcagaggt ttaagggccg ggtgaccatc acagctgatg agtccacaag caccacatat      240

atggagctga gctctctgcg cagcgaggac accgccgtgt actattgtgc ttctacactg      300

ggcctggtgc tggacgctat ggactattgg ggccagggca ccctggtgac agtctcgagc      360


<210>  57
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Light Region Engineered to Have 
       Sequences from Homo sapiens and Felis

<400>  57

Glu Thr Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Leu Gly Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Pro Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ala Asp Ser Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  58
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Light Region Engineered to Have 
       Sequences from Homo sapiens and Felis

<400>  58
gagaccgtgc tgacacagtc tcctggcacc ctgagcctgt ctccaggaga gagggccaca       60

ctgtcctgca gggcttccca gagcctgggc tccagctacc tggcctggta tcagcagaag      120

ccaggccagg ctcccaggct gctgatctac ggagcctctt ccagagctcc aggcatccct      180

gaccgcttct ctggatccgg aagcggcacc gacttcaccc tgacaatcag cagactggag      240

cccgaggact tcgccgtgta ctattgtcag cagtatgctg attctcctat cacatttggc      300

cagggtacca agctggagat caaa                                             324


<210>  59
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  59

Ser Asn Val Ile Ser 
1               5   


<210>  60
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  60

Gly Val Ile Pro Ile Val Asp Ile Ala Asn Tyr Ala Gln Arg Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  61
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  61

Ala Ser Thr Leu Gly Leu Val Leu Asp Ala Met Asp Tyr 
1               5                   10              


<210>  62
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  62

Arg Ala Ser Gln Ser Leu Gly Ser Ser Tyr 
1               5                   10  


<210>  63
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  63

Gly Ala Ser Ser Arg Ala Pro 
1               5           


<210>  64
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  64

Gln Gln Tyr Ala Asp Ser Pro Ile Thr 
1               5                   


<210>  65
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Heavy Region Engineered to Have 
       Sequences from Homo sapiens and Felis

<400>  65

Gln Val Leu Leu Val Gln Ser Gly Ala Asp Val Arg Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Phe Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Asn 
            20                  25                  30          


Val Ile Ser Trp Val Arg Gln Thr Pro Ala Gln Gly Phe Glu Trp Met 
        35                  40                  45              


Gly Gly Val Ile Pro Ile Val Asp Ile Ala Asn Tyr Ala Gln Arg Phe 
    50                  55                  60                  


Lys Gly Arg Leu Val Leu Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Lys Ser Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Leu Gly Leu Val Leu Asp Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Ser Leu Val Thr Val Ser Ser 
        115                 120 


<210>  66
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Heavy Region Engineered to Have 
       Sequences from Homo sapiens and Felis

<400>  66
caggtgctgc tggtgcagtc tggcgccgat gtgagaaagc caggcgctag cgtgaagatc       60

ttctgcaagg cctctggcta cacctttaca tctaacgtga tctcctgggt gcgccagaca      120

ccagctcagg gattcgagtg gatgggaggc gtgatcccta tcgtggacat cgccaactac      180

gctcagaggt ttaagggccg gctggtgctg accgctgata cctccacaaa taccgcttat      240

atggagctga ggtccctgaa gagcgccgac acagccgtgt actattgtgc ctccaccctg      300

ggactggtgc tggacgctat ggattattgg ggccagggca gcctggtgac agtctcgagc      360


<210>  67
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Light Region Engineered to Have 
       Sequences from Homo sapiens and Felis

<400>  67

Glu Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Leu Gly Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Pro Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr Ala Asp Ser Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  68
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Light Region Engineered to Have 
       Sequences from Homo sapiens and Felis

<400>  68
gagatccaga tgacccagtc tccttccagc ctgtctgcct ccccaggcga cagggtgacc       60

atcacatgcc gggccagcca gtctctgggc tcttcctacc tggcttggta tcagcagaag      120

ccaggcaagg tgcccaagct gctgatctac ggagccagct ctagagctcc aggcgtgcct      180

tcccgcttct ccggaagcgg atctggcaca gacttcaccc tgacaatctc cagcctggag      240

ccagaggacg ctgctaccta ctattgtcag cagtatgctg atagccctat cacattcggc      300

cagggtacca agctggagat caaa                                             324


<210>  69
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  69

Ser Asn Val Ile Ser 
1               5   


<210>  70
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  70

Gly Val Ile Pro Ile Val Asp Ile Ala Asn Tyr Ala Gln Arg Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  71
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  71

Ala Ser Thr Leu Gly Leu Val Leu Asp Ala Met Asp Tyr 
1               5                   10              


<210>  72
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  72

Arg Ala Ser Gln Ser Leu Gly Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  73
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  73

Gly Ala Ser Ser Arg Ala Pro 
1               5           


<210>  74
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  74

Gln Gln Tyr Ala Asp Ser Pro Ile Thr 
1               5                   


<210>  75
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Heavy Region Engineered to Have 
       Sequences from Homo sapiens and Felis

<400>  75

Gln Val Leu Leu Val Gln Ser Gly Ala Glu Val Arg Thr Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Phe Cys Lys Ala Ser Gly Tyr Gly Phe Thr Ser Asn 
            20                  25                  30          


Val Ile Ser Trp Val Arg Gln Ser Pro Ala Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Val Ile Pro Ile Val Asp Ile Ala Asn Tyr Ala Gln Arg Phe 
    50                  55                  60                  


Lys Gly Arg Leu Thr Leu Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Ala Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Leu Gly Leu Val Leu Asp Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  76
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Heavy Region Engineered to Have 
       Sequences from Homo sapiens and Felis

<400>  76
caggtgctgc tggtgcagtc tggcgccgag gtgagaacac caggcgctag cgtgaagatc       60

ttctgcaagg cctctggcta cggctttacc tctaacgtga tctcctgggt gcgccagtcc      120

ccagctcagg gactggagtg gatgggaggc gtgatcccta tcgtggacat cgccaattac      180

gctcagaggt tcaagggccg gctgaccctg acagctgaca cctccacaga taccgcttat      240

atggagctgt ccagcctgag gtccgccgat acagctatgt actattgtgc cagcaccctg      300

ggactggtgc tggacgctat ggattattgg ggccagggca cactggtgac cgtggtctcg      360

agc                                                                    363


<210>  77
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Light Region Engineered to Have 
       Sequences from Homo sapiens and Felis

<400>  77

Glu Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Leu Gly Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Pro Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr Ala Asp Ser Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  78
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Light Region Engineered to Have 
       Sequences from Homo sapiens and Felis

<400>  78
gagatccaga tgacccagtc tccttccagc ctgtctgcct ccccaggcga cagggtgacc       60

atcacatgcc gggccagcca gtctctgggc tcttcctacc tggcttggta tcagcagaag      120

ccaggcaagg tgcccaagct gctgatctac ggagccagct ctagagctcc aggcgtgcct      180

tcccgcttct ccggaagcgg atctggcaca gacttcaccc tgacaatctc cagcctggag      240

ccagaggacg ctgctaccta ctattgtcag cagtatgctg atagccctat cacattcggc      300

cagggtacca agctggagat caaa                                             324


<210>  79
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  79

Gly Tyr Thr Phe Ser Ser Asn Val 
1               5               


<210>  80
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  80

Val Ile Pro Ile Val Asp Ile Ala 
1               5               


<210>  81
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  81

Leu Gly Leu Val Leu Asp Ala Met Asp Tyr 
1               5                   10  


<210>  82
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  82

Arg Ala Ser Gln Ser Leu Gly Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  83
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  83

Gly Ala Ser Ser Arg Ala Pro 
1               5           


<210>  84
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  84

Gln Gln Tyr Ala Asp Ser Pro Ile Thr 
1               5                   


<210>  85
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Heavy Region Engineered to Have 
       Sequences from Homo sapiens and Felis

<400>  85

Gln Val Leu Leu Val Gln Ser Gly Ala Asp Val Arg Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Phe Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Asn 
            20                  25                  30          


Val Met His Trp Val Arg Gln Thr Pro Ala Gln Gly Phe Glu Trp Met 
        35                  40                  45              


Gly Ser Val Ile Pro Ile Val Asp Ile Ala Thr Tyr Ala Arg Arg Phe 
    50                  55                  60                  


Gln Gly Arg Leu Val Leu Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Lys Ser Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Leu Gly Leu Val Leu Asp Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Ser Leu Val Thr Val Ser Ser 
        115                 120 


<210>  86
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Heavy Region Engineered to Have 
       Sequences from Homo sapiens and Felis

<400>  86
caggtgctgc tggtgcagtc tggcgccgat gtgaggaagc caggcgctag cgtgaagatc       60

ttctgcaagg cctctggcta cacattttcc agcaacgtga tgcactgggt gagacagacc      120

cccgctcagg gcttcgagtg gatgggctcc gtgatcccta tcgtggacat cgccacatac      180

gctaggcggt ttcagggcag gctggtgctg accgccgata ccagcacaaa taccgcttat      240

atggagctga gatctctgaa gtccgccgac acagccgtgt actattgtgc tcgcaccctg      300

ggactggtgc tggacgctat ggattattgg ggccagggct ccctggtgac agtctcgagc      360


<210>  87
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Light Region Engineered to Have 
       Sequences from Homo sapiens and Felis

<400>  87

Glu Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Leu Gly Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Pro Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr Ala Asp Ser Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  88
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Light Region Engineered to Have 
       Sequences from Homo sapiens and Felis

<400>  88
gagatccaga tgacccagtc tccttccagc ctgtctgcct ccccaggcga cagggtgacc       60

atcacatgcc gggccagcca gtctctgggc tcttcctacc tggcttggta tcagcagaag      120

ccaggcaagg tgcccaagct gctgatctac ggagccagct ctagagctcc aggcgtgcct      180

tcccgcttct ccggaagcgg atctggcaca gacttcaccc tgacaatctc cagcctggag      240

ccagaggacg ctgctaccta ctattgtcag cagtatgctg atagccctat cacattcggc      300

cagggtacca agctggagat caaa                                             324


<210>  89
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  89

Gly Tyr Thr Phe Ser Ser Asn Val 
1               5               


<210>  90
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  90

Val Ile Pro Ile Val Asp Ile Ala 
1               5               


<210>  91
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  91

Leu Val Leu Asp Ala Met Asp Tyr 
1               5               


<210>  92
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  92

Arg Ala Ser Gln Ser Leu Gly Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  93
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  93

Gly Ala Ser Ser Arg Ala Pro 
1               5           


<210>  94
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  94

Gln Gln Tyr Ala Asp Ser Pro Ile Thr 
1               5                   


<210>  95
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Heavy Region Engineered to Have 
       Sequences from Homo sapiens and Felis

<400>  95

Asp Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Val Ala Ser Gly Tyr Thr Phe Ser Ser Asn 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ala Tyr Val Ile Pro Ile Val Asp Ile Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ile Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Leu Gly Leu Val Leu Asp Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  96
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Heavy Region Engineered to Have 
       Sequences from Homo sapiens and Felis

<400>  96
gacgtgcagc tggtggagtc tggaggcgat ctggtgaagc caggaggcag cctgaggctg       60

acctgcgtgg cttctggcta cacattctcc agcaacgtga tgcactgggt gcggcaggct      120

ccaggcaagg gactgcagtg ggtggcttat gtgatcccta tcgtggacat cgcctactat      180

gctgattccg tgaagggcag gttcaccatc tctatcgaca actccaagaa tacactgtac      240

ctgcagatga atagcctgaa gaccgaggat accgccacat actattgtgc tcgcacactg      300

ggcctggtgc tggacgctat ggattattgg ggccagggca ccctggtgac agtctcgagc      360


<210>  97
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Light Region Engineered to Have 
       Sequences from Homo sapiens and Felis

<400>  97

Glu Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Leu Gly Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Pro Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr Ala Asp Ser Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  98
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Light Region Engineered to Have 
       Sequences from Homo sapiens and Felis

<400>  98
gagatccaga tgacccagtc tccttccagc ctgtctgcct ccccaggcga cagggtgacc       60

atcacatgcc gggccagcca gtctctgggc tcttcctacc tggcttggta tcagcagaag      120

ccaggcaagg tgcccaagct gctgatctac ggagccagct ctagagctcc aggcgtgcct      180

tcccgcttct ccggaagcgg atctggcaca gacttcaccc tgacaatctc cagcctggag      240

ccagaggacg ctgctaccta ctattgtcag cagtatgctg atagccctat cacattcggc      300

cagggtacca agctggagat caaa                                             324


<210>  99
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  99

Gly Tyr Thr Phe Ser Ser Asn Val 
1               5               


<210>  100
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  100

Val Ile Pro Ile Val Asp Ile Ala 
1               5               


<210>  101
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  101

Leu Gly Leu Val Leu Asp Ala Met Asp Tyr 
1               5                   10  


<210>  102
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  102

Arg Ala Ser Gln Ser Leu Gly Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  103
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  103

Gly Ala Ser Ser Arg Ala Pro 
1               5           


<210>  104
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  104

Gln Gln Tyr Ala Asp Ser Pro Ile Thr 
1               5                   


<210>  105
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Heavy Region Engineered to Have 
       Sequences from Homo sapiens and Felis

<400>  105

Gln Val Leu Leu Val Gln Ser Gly Ala Asp Val Arg Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Phe Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Asn 
            20                  25                  30          


Val Met His Trp Val Arg Gln Thr Pro Ala Gln Gly Phe Glu Trp Met 
        35                  40                  45              


Gly Ser Val Ile Pro Ile Val Asp Ile Ala Thr Tyr Ala Arg Arg Phe 
    50                  55                  60                  


Gln Gly Arg Leu Val Leu Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Lys Ser Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Leu Gly Leu Val Leu Asp Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Ser Leu Val Thr Val Ser Ser 
        115                 120 


<210>  106
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Heavy Region Engineered to Have 
       Sequences from Homo sapiens and Felis

<400>  106
caggtgctgc tggtgcagtc tggcgccgat gtgaggaagc caggcgctag cgtgaagatc       60

ttctgcaagg cctctggcta cacattttcc agcaacgtga tgcactgggt gagacagacc      120

cccgctcagg gcttcgagtg gatgggctcc gtgatcccta tcgtggacat cgccacatac      180

gctaggcggt ttcagggcag gctggtgctg accgccgata ccagcacaaa taccgcttat      240

atggagctga gatctctgaa gtccgccgac acagccgtgt actattgtgc tcgcaccctg      300

ggactggtgc tggacgctat ggattattgg ggccagggct ccctggtgac agtctcgagc      360


<210>  107
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Light Region Engineered to Have 
       Sequences from Homo sapiens and Felis

<400>  107

Asp Ile Val Leu Thr Gln Pro Pro Ser Leu Ser Val Asn Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Arg Ala Ser Gln Ser Leu Gly Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Val Thr 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg Ala Pro Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Thr Asn Ser Gly Ile Thr Ala Thr Leu Thr Ile Ser Gly Ala Arg Ala 
65                  70                  75                  80  


Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Gln Tyr Ala Asp Ser Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  108
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Light Region Engineered to Have 
       Sequences from Homo sapiens and Felis

<400>  108
gacatcgtgc tgacacagcc ccctagcctg tctgtgaacc tgggacagac agctaggatc       60

acctgcaggg cttcccagag cctgggctcc agctacctgg cctggtatca gcagaagcct      120

ggccaggctc caaagctggt gacatacggc gcctcttcca gagctccagg catccccgac      180

cgcttctctg gcaccaattc cggcatcacc gccacactga ccatcagcgg agccagggct      240

gaggacgagg ctgattacta ttgtcagcag tatgctgatt ctcccatcac ctttggccag      300

ggtaccaagc tggagatcaa a                                                321


<210>  109
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  109

Gly Tyr Thr Phe Ser Ser Asn Val 
1               5               


<210>  110
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  110

Val Ile Pro Ile Val Asp Ile Ala 
1               5               


<210>  111
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  111

Leu Val Leu Asp Ala Met Asp Tyr 
1               5               


<210>  112
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  112

Arg Ala Ser Gln Ser Leu Gly Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  113
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  113

Gly Ala Ser Ser Arg Ala Pro 
1               5           


<210>  114
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  114

Gln Gln Tyr Ala Asp Ser Pro Ile Thr 
1               5                   


<210>  115
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Heavy Region Engineered to Have 
       Sequences from Homo sapiens and Felis

<400>  115

Asp Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Val Ala Ser Gly Tyr Thr Phe Ser Ser Asn 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ala Tyr Val Ile Pro Ile Val Asp Ile Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ile Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Leu Gly Leu Val Leu Asp Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  116
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Heavy Region Engineered to Have 
       Sequences from Homo sapiens and Felis

<400>  116
gacgtgcagc tggtggagtc tggaggcgat ctggtgaagc caggaggcag cctgaggctg       60

acctgcgtgg cttctggcta cacattctcc agcaacgtga tgcactgggt gcggcaggct      120

ccaggcaagg gactgcagtg ggtggcttat gtgatcccta tcgtggacat cgcctactat      180

gctgattccg tgaagggcag gttcaccatc tctatcgaca actccaagaa tacactgtac      240

ctgcagatga atagcctgaa gaccgaggat accgccacat actattgtgc tcgcacactg      300

ggcctggtgc tggacgctat ggattattgg ggccagggca ccctggtgac agtctcgagc      360


<210>  117
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Light Region Engineered to Have 
       Sequences from Homo sapiens and Felis

<400>  117

Asp Ile Val Leu Thr Gln Pro Pro Ser Leu Ser Val Asn Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Arg Ala Ser Gln Ser Leu Gly Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Val Thr 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg Ala Pro Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Thr Asn Ser Gly Ile Thr Ala Thr Leu Thr Ile Ser Gly Ala Arg Ala 
65                  70                  75                  80  


Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Gln Tyr Ala Asp Ser Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  118
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Light Region Engineered to Have 
       Sequences from Homo sapiens and Felis

<400>  118
gacatcgtgc tgacacagcc ccctagcctg tctgtgaacc tgggacagac agctaggatc       60

acctgcaggg cttcccagag cctgggctcc agctacctgg cctggtatca gcagaagcct      120

ggccaggctc caaagctggt gacatacggc gcctcttcca gagctccagg catccccgac      180

cgcttctctg gcaccaattc cggcatcacc gccacactga ccatcagcgg agccagggct      240

gaggacgagg ctgattacta ttgtcagcag tatgctgatt ctcccatcac ctttggccag      300

ggtaccaagc tggagatcaa a                                                321


<210>  119
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  119

Ser Asn Val Ile Ser 
1               5   


<210>  120
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  120

Gly Val Ile Pro Ile Val Asp Ile Ala Asn Tyr Ala Gln Arg Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  121
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  121

Ala Ser Thr Leu Gly Leu Val Leu Asp Ala Met Asp Tyr 
1               5                   10              


<210>  122
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  122

Arg Ala Ser Gln Ser Leu Gly Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  123
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  123

Gly Ala Ser Ser Arg Ala Pro 
1               5           


<210>  124
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  124

Gln Gln Tyr Ala Asp Ser Pro Ile Thr 
1               5                   


<210>  125
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Heavy Region Engineered to Have 
       Sequences from Homo sapiens and Felis

<400>  125

Gln Val Leu Leu Val Gln Ser Gly Ala Asp Val Arg Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Phe Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Asn 
            20                  25                  30          


Val Ile Ser Trp Val Arg Gln Thr Pro Ala Gln Gly Phe Glu Trp Met 
        35                  40                  45              


Gly Gly Val Ile Pro Ile Val Asp Ile Ala Asn Tyr Ala Gln Arg Phe 
    50                  55                  60                  


Lys Gly Arg Leu Val Leu Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Lys Ser Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Leu Gly Leu Val Leu Asp Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Ser Leu Val Thr Val Ser Ser 
        115                 120 


<210>  126
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Heavy Region Engineered to Have 
       Sequences from Homo sapiens and Felis

<400>  126
caggtgctgc tggtgcagtc tggcgccgat gtgagaaagc caggcgctag cgtgaagatc       60

ttctgcaagg cctctggcta cacctttaca tctaacgtga tctcctgggt gcgccagaca      120

ccagctcagg gattcgagtg gatgggaggc gtgatcccta tcgtggacat cgccaactac      180

gctcagaggt ttaagggccg gctggtgctg accgctgata cctccacaaa taccgcttat      240

atggagctga ggtccctgaa gagcgccgac acagccgtgt actattgtgc ctccaccctg      300

ggactggtgc tggacgctat ggattattgg ggccagggca gcctggtgac agtctcgagc      360


<210>  127
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Light Region Engineered to Have 
       Sequences from Homo sapiens and Felis

<400>  127

Asp Ile Val Met Thr Gln Ser Pro Gly Ser Leu Ala Gly Ser Pro Gly 
1               5                   10                  15      


Gln Gln Val Thr Met Asn Cys Arg Ala Ser Gln Ser Leu Gly Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln His Pro Glu Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Pro Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln 
65                  70                  75                  80  


Ala Glu Asp Val Ala Asn Tyr Tyr Cys Gln Gln Tyr Ala Asp Ser Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  128
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Light Region Engineered to Have 
       Sequences from Homo sapiens and Felis

<400>  128
gacatcgtga tgacccagtc ccctggcagc ctggctggaa gcccaggaca gcaggtgaca       60

atgaactgca gggccagcca gtctctgggc tccagctacc tggcttggta tcagcagaag      120

ccaggccagc accccgagct gctgatctac ggagcctctt ccagggctcc aggcgtgcct      180

gaccggttct ccggaagcgg atctggcacc gacttcaccc tgacaatctc taacctgcag      240

gccgaggacg tggctaatta ctattgtcag cagtatgctg attcccccat cacattcggc      300

cagggtacca agctggagat caaa                                             324


<210>  129
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  129

Gly Tyr Thr Phe Ser Ser Asn Val 
1               5               


<210>  130
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  130

Val Ile Pro Ile Val Asp Ile Ala 
1               5               


<210>  131
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  131

Leu Val Leu Asp Ala Met Asp Tyr 
1               5               


<210>  132
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  132

Arg Ala Ser Gln Ser Leu Gly Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  133
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  133

Gly Ala Ser Ser Arg Ala Pro 
1               5           


<210>  134
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  134

Gln Gln Tyr Ala Asp Ser Pro Ile Thr 
1               5                   


<210>  135
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Heavy Region Engineered to Have 
       Sequences from Homo sapiens and Felis

<400>  135

Asp Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Val Ala Ser Gly Tyr Thr Phe Ser Ser Asn 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ala Tyr Val Ile Pro Ile Val Asp Ile Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ile Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Leu Gly Leu Val Leu Asp Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  136
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Heavy Region Engineered to Have 
       Sequences from Homo sapiens and Felis

<400>  136
gacgtgcagc tggtggagtc tggaggcgat ctggtgaagc caggaggcag cctgaggctg       60

acctgcgtgg cttctggcta cacattctcc agcaacgtga tgcactgggt gcggcaggct      120

ccaggcaagg gactgcagtg ggtggcttat gtgatcccta tcgtggacat cgcctactat      180

gctgattccg tgaagggcag gttcaccatc tctatcgaca actccaagaa tacactgtac      240

ctgcagatga atagcctgaa gaccgaggat accgccacat actattgtgc tcgcacactg      300

ggcctggtgc tggacgctat ggattattgg ggccagggca ccctggtgac agtctcgagc      360


<210>  137
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Light Region Engineered to Have 
       Sequences from Homo sapiens and Felis

<400>  137

Asp Ile Val Met Thr Gln Ser Pro Gly Ser Leu Ala Gly Ser Pro Gly 
1               5                   10                  15      


Gln Gln Val Thr Met Asn Cys Arg Ala Ser Gln Ser Leu Gly Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln His Pro Glu Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Pro Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln 
65                  70                  75                  80  


Ala Glu Asp Val Ala Asn Tyr Tyr Cys Gln Gln Tyr Ala Asp Ser Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  138
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Felinized Sequence - Variable Light Region Engineered to Have 
       Sequences from Homo sapiens and Felis

<400>  138
gacatcgtga tgacccagtc ccctggcagc ctggctggaa gcccaggaca gcaggtgaca       60

atgaactgca gggccagcca gtctctgggc tccagctacc tggcttggta tcagcagaag      120

ccaggccagc accccgagct gctgatctac ggagcctctt ccagggctcc aggcgtgcct      180

gaccggttct ccggaagcgg atctggcacc gacttcaccc tgacaatctc taacctgcag      240

gccgaggacg tggctaatta ctattgtcag cagtatgctg attcccccat cacattcggc      300

cagggtacca agctggagat caaa                                             324


