                         SEQUENCE LISTING

<110>  Ionis Pharmaceuticals, Inc.
 
<120>  METHODS FOR REDUCING APOCIII EXPRESSION

<130>  BIOL0406WO

<150>  63/087,095
<151>  2020-10-02

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  3958
<212>  DNA
<213>  Homo sapiens

<400>  1
ctactccagg ctgtgttcag ggcttggggc tggtggaggg aggggcctga aattccagtg       60

tgaaaggctg agatgggccc gaggcccctg gcctatgtcc aagccatttc ccctctcacc      120

agcctctccc tggggagcca gtcagctagg aaggaatgag ggctccccag gcccaccccc      180

agttcctgag ctcatctggg ctgcagggct ggcgggacag cagcgtggac tcagtctcct      240

agggatttcc caactctccc gcccgcttgc tgcatctgga caccctgcct caggccctca      300

tctccactgg tcagcaggtg acctttgccc agcgccctgg gtcctcagtg cctgctgccc      360

tggagatgat ataaaacagg tcagaaccct cctgcctgtc tgctcagttc atccctagag      420

gcagctgctc caggtaatgc cctctgggga ggggaaagag gaggggagga ggatgaagag      480

gggcaagagg agctccctgc ccagcccagc cagcaagcct ggagaagcac ttgctagagc      540

taaggaagcc tcggagctgg acgggtgccc cccacccctc atcataacct gaagaacatg      600

gaggcccggg aggggtgtca cttgcccaaa gctacatagg gggtggggct ggaagtggct      660

ccaagtgcag gttcccccct cattcttcag gcttagggct ggaggaagcc ttagacagcc      720

cagtcctacc ccagacaggg aaactgaggc ctggagaggg ccagaaatca cccaaagaca      780

cacagcatgt tggctggact ggacggagat cagtccagac cgcaggtgcc ttgatgttca      840

gtctggtggg ttttctgctc catcccaccc acctcccttt gggcctcgat ccctcgcccc      900

tcaccagtcc cccttctgag agcccgtatt agcagggagc cggcccctac tccttctggc      960

agacccagct aaggttctac cttaggggcc acgccacctc cccagggagg ggtccagagg     1020

catggggacc tggggtgccc ctcacaggac acttccttgc aggaacagag gtgccatgca     1080

gccccgggta ctccttgttg ttgccctcct ggcgctcctg gcctctgccc gtaagcactt     1140

ggtgggactg ggctgggggc agggtggagg caacttgggg atcccagtcc caatgggtgg     1200

tcaagcagga gcccagggct cgtccatagg ccgatccacc ccactcagcc ctgctctttc     1260

ctcaggagct tcagaggccg aggatgcctc ccttctcagc ttcatgcagg gctacatgaa     1320

gcacgccacc aagaccgcca aggatgcact gagcagcgtg caggagtccc aggtggccca     1380

gcaggccagg tacacccgct ggcctccctc cccatccccc ctgccagctg cctccattcc     1440

cacccacccc tgccctggtg agatcccaac aatggaatgg aggtgctcca gcctcccctg     1500

ggcctgtgcc tcttcagcct cctctttcct cacagggcct ttgtcaggct gctgcgggag     1560

agatgacaga gttgagactg cattcctccc aggtccctcc tttctcccca gagcagtcct     1620

agggcgcgcc gttttagccc tcatttccat tttcctttcc tttccctttc tttccctttc     1680

tatttctttc tttctttctt tctttctttc tttctttctt tctttctttc tttctttctt     1740

tctttctttc ctttctttct ttcttttctt ctttctttct ttcctttctt tctctttctt     1800

tctttctttc tttccttttt ctttctttcc ctctcttcct ttctctcttt ctttcttctt     1860

cttttttttt taatggagtc tccctctgtc acccaggctg gagtgcagtg gtgccatctc     1920

ggctcactgc aacctccgtc tcccgggttc aacccattct cctgcctcag cctcccaagt     1980

agctgggatt acaggcacgc gccaccacac ccagctaatt tttgtatttt tagcagagat     2040

ggggtttcac catgttggcc aggttggtct tgaattcctg acctcagggg atcctcctgc     2100

ctcggcctcc caaagcgctg ggattacagg catgagccac tgcgcctggc cccattttcc     2160

ttttctgaag gtctggctag agcagtggtc ctcagccttt ttggcaccag ggaccagttt     2220

tgtggtggac aatttttcca tgggccagcg gggatggttt tgggatgaag ctgttccacc     2280

tcagatcatc aggcattaga ttctcataag gagccctcca cctagatccc tggcatgtgc     2340

agttcacaac agggttcaca ctcctatgag aatgtaaggc cacttgatct gacaggaggc     2400

ggagctcagg cggtattgct cactcaccca ccactcactt cgtgctgtgc agcccggctc     2460

ctaacagtcc atggaccagt acctatctat gacttggggg ttggggaccc ctgggctagg     2520

ggtttgcctt gggaggcccc acctgaccta attcaagccc gtgagtgctt ctgctttgtt     2580

ctaagacctg gggccagtgt gagcagaagt gtgtccttcc tctcccatcc tgcccctgcc     2640

catcagtact ctcctctccc ctactccctt ctccacctca ccctgactgg cattagctgg     2700

catagcagag gtgttcataa acattcttag tccccagaac cggctttggg gtaggtgtta     2760

ttttctcact ttgcagatga gaaaattgag gctcagagcg attaggtgac ctgccccaga     2820

tcacacaact aatcaatcct ccaatgactt tccaaatgag aggctgcctc cctctgtcct     2880

accctgctca gagccaccag gttgtgcaac tccaggcggt gctgtttgca cagaaaacaa     2940

tgacagcctt gacctttcac atctccccac cctgtcactt tgtgcctcag gcccaggggc     3000

ataaacatct gaggtgacct ggagatggca gggtttgact tgtgctgggg ttcctgcaag     3060

gatatctctt ctcccagggt ggcagctgtg ggggattcct gcctgaggtc tcagggctgt     3120

cgtccagtga agttgagagg gtggtgtggt cctgactggt gtcgtccagt ggggacatgg     3180

gtgtgggtcc catggttgcc tacagaggag ttctcatgcc ctgctctgtt gcttcccctg     3240

actgatttag gggctgggtg accgatggct tcagttccct gaaagactac tggagcaccg     3300

ttaaggacaa gttctctgag ttctgggatt tggaccctga ggtcagacca acttcagccg     3360

tggctgcctg agacctcaat accccaagtc cacctgccta tccatcctgc cagctccttg     3420

ggtcctgcaa tctccagggc tgcccctgta ggttgcttaa aagggacagt attctcagtg     3480

ctctcctacc ccacctcatg cctggccccc ctccaggcat gctggcctcc caataaagct     3540

ggacaagaag ctgctatgag tgggccgtcg caagtgtgcc atctgtgtct gggcatggga     3600

aagggccgag gctgttctgt gggtgggcac tggacagact ccaggtcagg caggcatgga     3660

ggccagcgct ctatccacct tctggtagct gggcagtctc tgggcctcag tttcttcatc     3720

tctaaggtag gaatcaccct ccgtaccctg ccttccttga cagctttgtg cggaaggtca     3780

aacaggacaa taagtttgct gatactttga taaactgtta ggtgctgcac aacatgactt     3840

gagtgtgtgc cccatgccag ccactatgcc tggcacttaa gttgtcatca gagttgagac     3900

tgtgtgtgtt tactcaaaac tgtggagctg acctccccta tccaggccac ctagccct       3958


<210>  2
<211>  567
<212>  DNA
<213>  Homo sapiens

<400>  2
aaccctcctg cctgtctgct cagttcatcc ctagaggcag ctgctccagg aacagaggtg       60

ccatgcagcc ccgggtactc cttgttgttg ccctcctggc gctcctggcc tctgcccgag      120

cttcagaggc cgaggatgcc tcccttctca gcttcatgca gggttacatg aagcacgcca      180

ccaagaccgc caaggatgca ctgagcagcg tgcaggagtc ccaggtggcc cagcaggcca      240

ggggctgggt gaccgatggc ttcagttccc tgaaagacta ctggagcacc gttaaggaca      300

agttctctga gttctgggat ttggaccctg aggtcagacc aacttcagcc gtggctgcct      360

gagacctcaa taccccaagt ccacctgcct atccatcctg cgagctcctt gggtcctgca      420

atctccaggg ctgcccctgt aggttgctta aaagggacag tattctcagt gctctcctac      480

cccacctcat gcctggcccc cctccaggca tgctggcctc ccaataaagc tggacaagaa      540

gctgctatga gtaaaaaaaa aaaaaaa                                          567


<210>  3
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  3
agcttcttgt ccagctttat                                                   20


