                         SEQUENCE LISTING

<110>  Generoath Co., Ltd.
 
<120>  METHODS OF TREATING AGE-RELATED MACULAR DISEASES USING AIMP2-DX2 
       AND OPTIONALLY A TARGET SEQUENCE FOR miR 142 AND COMPOSITIONS 
       THEREOF

<130>  2493-0005WO01

<150>  US 63/085,922
<151>  2020-09-30

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  756
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AIMP2-DX2

<400>  1
atgccgatgt accaggtaaa gccctatcac gggggcggcg cgcctctccg tgtggagctt       60

cccacctgca tgtaccggct ccccaacgtg cacggcagga gctacggccc agcgccgggc      120

gctggccacg tgcaggatta cggggcgctg aaagacatcg tgatcaacgc aaacccggcc      180

tcccctcccc tctccctgct tgtgctgcac aggctgctct gtgagcactt cagggtcctg      240

tccacggtgc acacgcactc ctcggtcaag agcgtgcctg aaaaccttct caagtgcttt      300

ggagaacaga ataaaaaaca gccccgccaa gactatcagc tgggattcac tttaatttgg      360

aagaatgtgc cgaagacgca gatgaaattc agcatccaga cgatgtgccc catcgaaggc      420

gaagggaaca ttgcacgttt cttgttctct ctgtttggcc agaagcataa tgctgtcaac      480

gcaaccctta tagatagctg ggtagatatt gcgatttttc agttaaaaga gggaagcagt      540

aaagaaaaag ccgctgtttt ccgctccatg aactctgctc ttgggaagag cccttggctc      600

gctgggaatg aactcaccgt agcagacgtg gtgctgtggt ctgtactcca gcagatcgga      660

ggctgcagtg tgacagtgcc agccaatgtg cagaggtgga tgaggtcttg tgaaaacctg      720

gctcctttta acacggccct caagctcctt aagtga                                756


<210>  2
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIMP2-DX2

<400>  2

Met Pro Met Tyr Gln Val Lys Pro Tyr His Gly Gly Gly Ala Pro Leu 
1               5                   10                  15      


Arg Val Glu Leu Pro Thr Cys Met Tyr Arg Leu Pro Asn Val His Gly 
            20                  25                  30          


Arg Ser Tyr Gly Pro Ala Pro Gly Ala Gly His Val Gln Asp Tyr Gly 
        35                  40                  45              


Ala Leu Lys Asp Ile Val Ile Asn Ala Asn Pro Ala Ser Pro Pro Leu 
    50                  55                  60                  


Ser Leu Leu Val Leu His Arg Leu Leu Cys Glu His Phe Arg Val Leu 
65                  70                  75                  80  


Ser Thr Val His Thr His Ser Ser Val Lys Ser Val Pro Glu Asn Leu 
                85                  90                  95      


Leu Lys Cys Phe Gly Glu Gln Asn Lys Lys Gln Pro Arg Gln Asp Tyr 
            100                 105                 110         


Gln Leu Gly Phe Thr Leu Ile Trp Lys Asn Val Pro Lys Thr Gln Met 
        115                 120                 125             


Lys Phe Ser Ile Gln Thr Met Cys Pro Ile Glu Gly Glu Gly Asn Ile 
    130                 135                 140                 


Ala Arg Phe Leu Phe Ser Leu Phe Gly Gln Lys His Asn Ala Val Asn 
145                 150                 155                 160 


Ala Thr Leu Ile Asp Ser Trp Val Asp Ile Ala Ile Phe Gln Leu Lys 
                165                 170                 175     


Glu Gly Ser Ser Lys Glu Lys Ala Ala Val Phe Arg Ser Met Asn Ser 
            180                 185                 190         


Ala Leu Gly Lys Ser Pro Trp Leu Ala Gly Asn Glu Leu Thr Val Ala 
        195                 200                 205             


Asp Val Val Leu Trp Ser Val Leu Gln Gln Ile Gly Gly Cys Ser Val 
    210                 215                 220                 


Thr Val Pro Ala Asn Val Gln Arg Trp Met Arg Ser Cys Glu Asn Leu 
225                 230                 235                 240 


Ala Pro Phe Asn Thr Ala Leu Lys Leu Leu Lys 
                245                 250     


<210>  3
<211>  936
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AIMP2

<400>  3
atgccgatgt accaggtaaa gccctatcac gggggcggcg cgcctctccg tgtggagctt       60

cccacctgca tgtaccggct ccccaacgtg cacggcagga gctacggccc agcgccgggc      120

gctggccacg tgcaggaaga gtctaacctg tctctgcaag ctcttgagtc ccgccaagat      180

gatattttaa aacgtctgta tgagttgaaa gctgcagttg atggcctctc caagatgatt      240

caaacaccag atgcagactt ggatgtaacc aacataatcc aagcggatga gcccacgact      300

ttaaccacca atgcgctgga cttgaattca gtgcttggga aggattacgg ggcgctgaaa      360

gacatcgtga tcaacgcaaa cccggcctcc cctcccctct ccctgcttgt gctgcacagg      420

ctgctctgtg agcacttcag ggtcctgtcc acggtgcaca cgcactcctc ggtcaagagc      480

gtgcctgaaa accttctcaa gtgctttgga gaacagaata aaaaacagcc ccgccaagac      540

tatcagctgg gattcacttt aatttggaag aatgtgccga agacgcagat gaaattcagc      600

atccagacga tgtgccccat cgaaggcgaa gggaacattg cacgtttctt gttctctctg      660

tttggccaga agcataatgc tgtcaacgca acccttatag atagctgggt agatattgcg      720

atttttcagt taaaagaggg aagcagtaaa gaaaaagccg ctgttttccg ctccatgaac      780

tctgctcttg ggaagagccc ttggctcgct gggaatgaac tcaccgtagc agacgtggtg      840

ctgtggtctg tactccagca gatcggaggc tgcagtgtga cagtgccagc caatgtgcag      900

aggtggatga ggtcttgtga aaacctggct cctttt                                936


<210>  4
<211>  207
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exon 2 of AIMP2

<400>  4
gaagagtcta acctgtctct gcaagctctt gagtcccgcc aagatgatat tttaaaacgt       60

ctgtatgagt tgaaagctgc agttgatggc ctctccaaga tgattcaaac accagatgca      120

gacttggatg taaccaacat aatccaagcg gatgagccca cgactttaac caccaatgcg      180

ctggacttga attcagtgct tgggaag                                          207


<210>  5
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  miR-142-3p target sequence

<400>  5
tccataaagt aggaaacact aca                                               23


<210>  6
<211>  132
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4 repeats of miR-142-3p target sequence

<400>  6
ccagaagctt gctagctcca taaagtagga aacactacat cactccataa agtaggaaac       60

actacagata tctccataaa gtaggaaaca ctacatcact ccataaagta ggaaacacta      120

caaagcttgt ag                                                          132


<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  miR-142-5p target sequence

<400>  7
agtagtgctt tctactttat g                                                 21


<210>  8
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AIMP2 variant forward primer

<400>  8
ctggccacgt gcaggattac gggg                                              24


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AIMP2 variant reverse primer

<400>  9
aagtgaatcc cagctgatag                                                   20


<210>  10
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exon 2 of AIMP2

<400>  10

Glu Glu Ser Asn Leu Ser Leu Gln Ala Leu Glu Ser Arg Gln Asp Asp 
1               5                   10                  15      


Ile Leu Lys Arg Leu Tyr Glu Leu Lys Ala Ala Val Asp Gly Leu Ser 
            20                  25                  30          


Lys Met Ile Gln Thr Pro Asp Ala Asp Leu Asp Val Thr Asn Ile Ile 
        35                  40                  45              


Gln Ala Asp Glu Pro Thr Thr Leu Thr Thr Asn Ala Leu Asp Leu Asn 
    50                  55                  60                  


Ser Val Leu Gly Lys 
65                  


<210>  11
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exon 2 of AIMP2 variant

<400>  11

Met Ile Gln Thr Pro Asp Ala Asp Leu Asp Val Thr Asn Ile Ile Gln 
1               5                   10                  15      


Ala Asp Glu Pro Thr Thr Leu Thr Thr Asn Ala Leu Asp Leu Asn Ser 
            20                  25                  30          


Val Leu Gly Lys 
        35      


<210>  12
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIMP2

<400>  12

Met Pro Met Tyr Gln Val Lys Pro Tyr His Gly Gly Gly Ala Pro Leu 
1               5                   10                  15      


Arg Val Glu Leu Pro Thr Cys Met Tyr Arg Leu Pro Asn Val His Gly 
            20                  25                  30          


Arg Ser Tyr Gly Pro Ala Pro Gly Ala Gly His Val Gln Glu Glu Ser 
        35                  40                  45              


Asn Leu Ser Leu Gln Ala Leu Glu Ser Arg Gln Asp Asp Ile Leu Lys 
    50                  55                  60                  


Arg Leu Tyr Glu Leu Lys Ala Ala Val Asp Gly Leu Ser Lys Met Ile 
65                  70                  75                  80  


Gln Thr Pro Asp Ala Asp Leu Asp Val Thr Asn Ile Ile Gln Ala Asp 
                85                  90                  95      


Glu Pro Thr Thr Leu Thr Thr Asn Ala Leu Asp Leu Asn Ser Val Leu 
            100                 105                 110         


Gly Lys Asp Tyr Gly Ala Leu Lys Asp Ile Val Ile Asn Ala Asn Pro 
        115                 120                 125             


Gly Ser Pro Pro Leu Ser Leu Leu Val Leu His Arg Leu Leu Cys Glu 
    130                 135                 140                 


His Phe Arg Val Leu Ser Thr Val His Thr His Ser Ser Val Lys Ser 
145                 150                 155                 160 


Val Pro Glu Asn Leu Leu Lys Cys Phe Gly Glu Gln Asn Lys Lys Gln 
                165                 170                 175     


Pro Arg Gln Asp Tyr Gln Leu Gly Phe Thr Leu Ile Trp Lys Asn Val 
            180                 185                 190         


Pro Lys Thr Gln Met Lys Phe Ser Ile Gln Thr Met Cys Pro Ile Glu 
        195                 200                 205             


Gly Glu Gly Asn Ile Ala Arg Phe Leu Phe Ser Leu Phe Gly Gln Lys 
    210                 215                 220                 


His Asn Ala Val Asn Ala Thr Leu Ile Asp Ser Trp Val Asp Ile Ala 
225                 230                 235                 240 


Ile Phe Gln Leu Lys Glu Gly Ser Ser Lys Glu Lys Ala Ala Val Phe 
                245                 250                 255     


Arg Ser Met Asn Ser Ala Leu Gly Lys Ser Pro Trp Leu Ala Gly Asn 
            260                 265                 270         


Glu Leu Thr Val Ala Asp Val Val Leu Trp Ser Val Leu Gln Gln Ile 
        275                 280                 285             


Gly Gly Cys Ser Val Thr Val Pro Ala Asn Val Gln Arg Trp Met Arg 
    290                 295                 300                 


Ser Cys Glu Asn Leu Ala Pro Phe Asn Thr Ala Leu Lys Leu Leu Lys 
305                 310                 315                 320 


<210>  13
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIMP-DX2 variant 1

<400>  13

Met Pro Met Tyr Gln Val Lys Pro Tyr His Gly Gly Gly Ala Pro Leu 
1               5                   10                  15      


Arg Val Glu Leu Pro Thr Cys Met Tyr Arg Leu Pro Asn Val His Gly 
            20                  25                  30          


Arg Ser Tyr Gly Pro Ala Pro Gly Ala Gly His Val Gln Asp Tyr Gly 
        35                  40                  45              


Ala Leu Lys Asp Ile Val Ile Asn Ala Asn Pro Ala Ser Pro Pro Leu 
    50                  55                  60                  


Ser Leu Leu Val Leu His Arg Leu Leu Cys Glu His Phe Arg Val Leu 
65                  70                  75                  80  


Ser Thr Val His Thr His Ser Ser Val Lys Ser Val Pro Glu Asn Leu 
                85                  90                  95      


Leu Lys Cys Phe Gly Glu Gln Asn Lys Lys Gln Pro Arg Gln Asp Tyr 
            100                 105                 110         


Gln Leu Gly Phe Thr Leu Ile Trp Lys Asn Val Pro Lys Thr Gln Met 
        115                 120                 125             


Lys Phe Ser Ile Gln Thr Met Cys Pro Ile Glu Gly Glu Gly Asn Ile 
    130                 135                 140                 


Ala Arg Phe Leu Phe Ser Leu Phe Gly Gln Lys His Asn Ala Val Asn 
145                 150                 155                 160 


Ala Thr Leu Ile Asp Ser Trp Val Asp Ile Ala Ile Phe Gln Leu Lys 
                165                 170                 175     


Glu Gly Ser Ser Lys Glu Lys Ala Ala Val Phe Arg Ser Met Asn Ser 
            180                 185                 190         


Ala Leu Gly Lys Ser Pro Trp Leu Ala Gly Asn Glu Leu Thr Val Ala 
        195                 200                 205             


Asp Val Val Leu Trp Ser Val Leu Gln Gln Ile Gly Gly Cys Ser Val 
    210                 215                 220                 


Thr Val Pro Ala Asn Val Gln Arg Trp Met Arg Ser Cys Glu Asn Leu 
225                 230                 235                 240 


Ala Pro Phe 
            


<210>  14
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIMP2-DX2 variant 2

<400>  14

Met Gln Met Glu Gly Thr Ala His Val Lys Ile Cys Gly Gln Ser Gln 
1               5                   10                  15      


Gly Gly Gly Leu Gly Thr Pro Arg Thr Val Trp Leu Glu His Arg Gln 
            20                  25                  30          


Arg Thr Lys Leu Gly Glu Asp Tyr Gly Ala Leu Lys Asp Ile Val Ile 
        35                  40                  45              


Asn Ala Asn Pro Ala Ser Pro Pro Leu Ser Leu Leu Val Leu His Arg 
    50                  55                  60                  


Leu Leu Cys Glu His Phe Arg Val Leu Ser Thr Val His Thr His Ser 
65                  70                  75                  80  


Ser Val Lys Ser Val Pro Glu Asn Leu Leu Lys Cys Phe Gly Glu Gln 
                85                  90                  95      


Asn Lys Lys Gln Pro Arg Gln Asp Tyr Gln Leu Gly Phe Thr Leu Ile 
            100                 105                 110         


Trp Lys Asn Val Pro Lys Thr Gln Met Lys Phe Ser Ile Gln Thr Met 
        115                 120                 125             


Cys Pro Ile Glu Gly Glu Gly Asn Ile Ala Arg Phe Leu Phe Ser Leu 
    130                 135                 140                 


Phe Gly Gln Lys His Asn Ala Val Asn Ala Thr Leu Ile Asp Ser Trp 
145                 150                 155                 160 


Val Asp Ile Ala Ile Phe Gln Leu Lys Glu Gly Ser Ser Lys Glu Lys 
                165                 170                 175     


Ala Ala Val Phe Arg Ser Met Asn Ser Ala Leu Gly Lys Ser Pro Trp 
            180                 185                 190         


Leu Ala Gly Asn Glu Leu Thr Val Ala Asp Val Val Leu Trp Ser Val 
        195                 200                 205             


Leu Gln Gln Ile Gly Gly Cys Ser Val Thr Val Pro Ala Asn Val Gln 
    210                 215                 220                 


Arg Trp Met Arg Ser Cys Glu Asn Leu Ala Pro Phe Asn Thr Ala Leu 
225                 230                 235                 240 


Lys Leu Leu Lys 
                


<210>  15
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIMP2-DX2 variant 3

<400>  15

Met Asp Tyr Gly Ala Leu Lys Asp Ile Val Ile Asn Ala Asn Pro Ala 
1               5                   10                  15      


Ser Pro Pro Leu Ser Leu Leu Val Leu His Arg Leu Leu Cys Glu His 
            20                  25                  30          


Phe Arg Val Leu Ser Thr Val His Thr His Ser Ser Val Lys Ser Val 
        35                  40                  45              


Pro Glu Asn Leu Leu Lys Cys Phe Gly Glu Gln Asn Lys Lys Gln Pro 
    50                  55                  60                  


Arg Gln Asp Tyr Gln Leu Gly Phe Thr Leu Ile Trp Lys Asn Val Pro 
65                  70                  75                  80  


Lys Thr Gln Met Lys Phe Ser Ile Gln Thr Met Cys Pro Ile Glu Gly 
                85                  90                  95      


Glu Gly Asn Ile Ala Arg Phe Leu Phe Ser Leu Phe Gly Gln Lys His 
            100                 105                 110         


Asn Ala Val Asn Ala Thr Leu Ile Asp Ser Trp Val Asp Ile Ala Ile 
        115                 120                 125             


Phe Gln Leu Lys Glu Gly Ser Ser Lys Glu Lys Ala Ala Val Phe Arg 
    130                 135                 140                 


Ser Met Asn Ser Ala Leu Gly Lys Ser Pro Trp Leu Ala Gly Asn Glu 
145                 150                 155                 160 


Leu Thr Val Ala Asp Val Val Leu Trp Ser Val Leu Gln Gln Ile Gly 
                165                 170                 175     


Gly Cys Ser Val Thr Val Pro Ala Asn Val Gln Arg Trp Met Arg Ser 
            180                 185                 190         


Cys Glu Asn Leu Ala Pro Phe Asn Thr Ala Leu Lys Leu Leu Lys 
        195                 200                 205         


<210>  16
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIMP2-DX2 variant 4

<400>  16

Met Asn Ser Pro Ala Val Asn Thr Leu Ile Gln Arg Ser Arg His Gly 
1               5                   10                  15      


Asp Tyr Gly Ala Leu Lys Asp Ile Val Ile Asn Ala Asn Pro Ala Ser 
            20                  25                  30          


Pro Pro Leu Ser Leu Leu Val Leu His Arg Leu Leu Cys Glu His Phe 
        35                  40                  45              


Arg Val Leu Ser Thr Val His Thr His Ser Ser Val Lys Ser Val Pro 
    50                  55                  60                  


Glu Asn Leu Leu Lys Cys Phe Gly Glu Gln Asn Lys Lys Gln Pro Arg 
65                  70                  75                  80  


Gln Asp Tyr Gln Leu Gly Phe Thr Leu Ile Trp Lys Asn Val Pro Lys 
                85                  90                  95      


Thr Gln Met Lys Phe Ser Ile Gln Thr Met Cys Pro Ile Glu Gly Glu 
            100                 105                 110         


Gly Asn Ile Ala Arg Phe Leu Phe Ser Leu Phe Gly Gln Lys His Asn 
        115                 120                 125             


Ala Val Asn Ala Thr Leu Ile Asp Ser Trp Val Asp Ile Ala Ile Phe 
    130                 135                 140                 


Gln Leu Lys Glu Gly Ser Ser Lys Glu Lys Ala Ala Val Phe Arg Ser 
145                 150                 155                 160 


Met Asn Ser Ala Leu Gly Lys Ser Pro Trp Leu Ala Gly Asn Glu Leu 
                165                 170                 175     


Thr Val Ala Asp Val Val Leu Trp Ser Val Leu Gln Gln Ile Gly Gly 
            180                 185                 190         


Cys Ser Val Thr Val Pro Ala Asn Val Gln Arg Trp Met Arg Ser Cys 
        195                 200                 205             


Glu Asn Leu Ala Pro Phe Asn Thr Ala Leu Lys Leu Leu Lys 
    210                 215                 220         


<210>  17
<211>  211
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIMP2-DX2 variant 5

<400>  17

Met Pro Met Tyr Gln Asp Tyr Gly Ala Leu Lys Asp Ile Val Ile Asn 
1               5                   10                  15      


Ala Asn Pro Ala Ser Pro Pro Leu Ser Leu Leu Val Leu His Arg Leu 
            20                  25                  30          


Leu Cys Glu His Phe Arg Val Leu Ser Thr Val His Thr His Ser Ser 
        35                  40                  45              


Val Lys Ser Val Pro Glu Asn Leu Leu Lys Cys Phe Gly Glu Gln Asn 
    50                  55                  60                  


Lys Lys Gln Pro Arg Gln Asp Tyr Gln Leu Gly Phe Thr Leu Ile Trp 
65                  70                  75                  80  


Lys Asn Val Pro Lys Thr Gln Met Lys Phe Ser Ile Gln Thr Met Cys 
                85                  90                  95      


Pro Ile Glu Gly Glu Gly Asn Ile Ala Arg Phe Leu Phe Ser Leu Phe 
            100                 105                 110         


Gly Gln Lys His Asn Ala Val Asn Ala Thr Leu Ile Asp Ser Trp Val 
        115                 120                 125             


Asp Ile Ala Ile Phe Gln Leu Lys Glu Gly Ser Ser Lys Glu Lys Ala 
    130                 135                 140                 


Ala Val Phe Arg Ser Met Asn Ser Ala Leu Gly Lys Ser Pro Trp Leu 
145                 150                 155                 160 


Ala Gly Asn Glu Leu Thr Val Ala Asp Val Val Leu Trp Ser Val Leu 
                165                 170                 175     


Gln Gln Ile Gly Gly Cys Ser Val Thr Val Pro Ala Asn Val Gln Arg 
            180                 185                 190         


Trp Met Arg Ser Cys Glu Asn Leu Ala Pro Phe Asn Thr Ala Leu Lys 
        195                 200                 205             


Leu Leu Lys 
    210     


<210>  18
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIMP2-DX2 variant 6

<400>  18

Met Pro Met Tyr Gln Val Lys Pro Tyr His Gly Gly Gly Ala Pro Leu 
1               5                   10                  15      


Arg Val Glu Leu Pro Thr Cys Met Tyr Arg Leu Pro Asn Val His Gly 
            20                  25                  30          


Arg Ser Tyr Gly Pro Ala Pro Gly Ala Gly His Val Gln Asp Tyr Gly 
        35                  40                  45              


Ala Leu Lys Asp Ile Val Ile Asn Ala Asn Pro Ala Ser Pro Pro Leu 
    50                  55                  60                  


Ser Leu Leu Val Leu His Arg Leu Leu Cys Glu His Phe Arg Val Leu 
65                  70                  75                  80  


Ser Thr Val His Thr His Ser Ser Val Lys Ser Val Pro Glu Asn Leu 
                85                  90                  95      


Leu Lys Cys Phe Gly Glu Gln Asn Lys Lys Gln Pro Arg Gln Asp Tyr 
            100                 105                 110         


Gln Leu Gly Phe Thr Leu Ile Trp Lys Asn Val Pro Lys Thr Gln Met 
        115                 120                 125             


Lys Phe Ser Ile Gln Thr Met Cys Pro Ile Glu Gly Glu Gly Asn Ile 
    130                 135                 140                 


Ala Arg Phe Leu Phe Ser Leu Phe Gly Gln Lys His Asn Ala Val Asn 
145                 150                 155                 160 


Ala Thr Leu Ile Asp Ser Trp Val Asp Ile Ala Ile Phe Gln Leu Lys 
                165                 170                 175     


Glu Gly Ser Ser Lys Glu Lys Ala Ala Val Phe Arg Ser Met Asn Ser 
            180                 185                 190         


Ala Leu Gly Lys Ser Pro Trp Leu Ala Gly Asn Glu Leu Thr Val Ala 
        195                 200                 205             


Asp Val Val Leu Trp Ser Val Leu Gln Gln Ile Gly Gly Cys Ser Val 
    210                 215                 220                 


Thr Val Pro Ala Asn Val Gln Arg Trp Met Arg Ser Cys Glu Asn Leu 
225                 230                 235                 240 


Ala Pro Phe Asn Thr Ala Leu Lys Leu Leu Lys 
                245                 250     


<210>  19
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIMP2-DX2 variant 7

<400>  19

Asp Tyr Gly Ala Leu Lys Asp Ile Val Ile Asn Ala Asn Pro Ala Ser 
1               5                   10                  15      


Pro Pro Leu Ser Leu Leu Val Leu His Arg Leu Leu Cys Glu His Phe 
            20                  25                  30          


Arg Val Leu Ser Thr Val His Thr His Ser Ser Val Lys Ser Val Pro 
        35                  40                  45              


Glu Asn Leu Leu Lys Cys Phe Gly Glu Gln Asn Lys Lys Gln Pro Arg 
    50                  55                  60                  


Gln Asp Tyr Gln Leu Gly Phe Thr Leu Ile Trp Lys Asn Val Pro Lys 
65                  70                  75                  80  


Thr Gln Met Lys Phe Ser Ile Gln Thr Met Cys Pro Ile Glu Gly Glu 
                85                  90                  95      


Gly Asn Ile Ala Arg Phe Leu Phe Ser Leu Phe Gly Gln Lys His Asn 
            100                 105                 110         


Ala Val Asn Ala Thr Leu Ile Asp Ser Trp Val Asp Ile Ala Ile Phe 
        115                 120                 125             


Gln Leu Lys Glu Gly Ser Ser Lys Glu Lys Ala Ala Val Phe Arg Ser 
    130                 135                 140                 


Met Asn Ser Ala Leu Gly Lys Ser Pro Trp Leu Ala Gly Asn Glu Leu 
145                 150                 155                 160 


Thr Val Ala Asp Val Val Leu Trp Ser Val Leu Gln Gln Ile Gly Gly 
                165                 170                 175     


Cys Ser Val Thr Val Pro Ala Asn Val Gln Arg Trp Met Arg Ser Cys 
            180                 185                 190         


Glu Asn Leu Ala Pro Phe Asn Thr Ala Leu Lys Leu Leu Lys 
        195                 200                 205     


<210>  20
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIMP2-DX2 consensus sequence

<400>  20

Asp Tyr Gly Ala Leu Lys Asp Ile Val Ile Asn Ala Asn Pro Ala Ser 
1               5                   10                  15      


Pro Pro Leu Ser Leu Leu Val Leu His Arg Leu Leu Cys Glu His Phe 
            20                  25                  30          


Arg Val Leu Ser Thr Val His Thr His Ser Ser Val Lys Ser Val Pro 
        35                  40                  45              


Glu Asn Leu Leu Lys Cys Phe Gly Glu Gln Asn Lys Lys Gln Pro Arg 
    50                  55                  60                  


Gln Asp Tyr Gln Leu Gly Phe Thr Leu Ile Trp Lys Asn Val Pro Lys 
65                  70                  75                  80  


Thr Gln Met Lys Phe Ser Ile Gln Thr Met Cys Pro Ile Glu Gly Glu 
                85                  90                  95      


Gly Asn Ile Ala Arg Phe Leu Phe Ser Leu Phe Gly Gln Lys His Asn 
            100                 105                 110         


Ala Val Asn Ala Thr Leu Ile Asp Ser Trp Val Asp Ile Ala Ile Phe 
        115                 120                 125             


Gln Leu Lys Glu Gly Ser Ser Lys Glu Lys Ala Ala Val Phe Arg Ser 
    130                 135                 140                 


Met Asn Ser Ala Leu Gly Lys Ser Pro Trp Leu Ala Gly Asn Glu Leu 
145                 150                 155                 160 


Thr Val Ala Asp Val Val Leu Trp Ser Val Leu Gln Gln Ile Gly Gly 
                165                 170                 175     


Cys Ser Val Thr Val Pro Ala Asn Val Gln Arg Trp Met Arg Ser Cys 
            180                 185                 190         


Glu Asn Leu Ala Pro Phe 
        195             


<210>  21
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nhe1, Hind III, and Bmt1 sites in miR-142-3pT with 4 repeats

<400>  21
ccagaagctt gctagc                                                       16


<210>  22
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hind H site in miR-142-3pT with 4 repeats

<400>  22
aagcttgtag                                                              10


<210>  23
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-142-3p

<400>  23
uguaguguuu ccuacuuuau gga                                               23


<210>  24
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-142-5p

<400>  24
cauaaaguag aaagcacuac u                                                 21


<210>  25
<211>  238
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  miR-142-3pT target sequence mutant

<400>  25
ccgctgcagt gtgacagtgc cagccaatgt gcagaggtgg atgaggtctt gtgaaaacct       60

ggctcctttt aacacggccc tcaagctcct taagtgacca gaagcttgct agctccataa      120

agtaggacca ctgcaatcac tccataaagt aggaccactg caagatatct ccataaagta      180

ggaccactgc aatcactcca taaagtagga ccactgcaaa agcttgtagg gatccgcc        238


