                         SEQUENCE LISTING

<110>  AprilBio Co., Ltd.
 
<120>  RECOMBINANT FUSION PROTEINS COMPRISING INTERLEUKIN-18-BINDING 
       PROTEIN AND ANTIGEN BINDING FRAGMENT TO SERUM ALBUMIN, AND 
       COMPOSITIONS AND USES THEREOF

<130>  2662-0005WO01

<150>  KR 10-2020-0127395
<151>  2020-09-29

<160>  85    

<170>  PatentIn version 3.5

<210>  1
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  Forwared primer of SL335 H Xba1 Kozak

<400>  1
gatcaactct agagccacca tggagtggtc ctgggt                                 36


<210>  2
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer of GS vector GSAP linker

<400>  2
gtgctacctg gggcaggggc tgacccg                                           27


<210>  3
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer of GS vector GSAP linker

<400>  3
cgggtcagcc cctgccccag gtagcac                                           27


<210>  4
<211>  47
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer of huIL18BP Not1, Bbs1

<400>  4
cgcgaagacg cttttagagc ggccgcgtct acctaccctt gctgctg                     47


<210>  5
<211>  55
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer of huIL18BP only

<400>  5
ggctgagcgg ggtggagggg acacctgtgt cccagaccac aacagccgct acagc            55


<210>  6
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer of huIL18BP his8 BbsI NotI

<400>  6
atcggcggcc gcgaagacgc ttttagatca gtggtggtgg tgatggtggt ggtgcccccc       60

ttgctgctgt gggctagaat ggctacttgg                                        90


<210>  7
<211>  164
<212>  PRT
<213>  Artificial

<220>
<223>  IL-18BP

<400>  7

Thr Pro Val Ser Gln Thr Thr Thr Ala Ala Thr Ala Ser Val Arg Ser 
1               5                   10                  15      


Thr Lys Asp Pro Cys Pro Ser Gln Pro Pro Val Phe Pro Ala Ala Lys 
            20                  25                  30          


Gln Cys Pro Ala Leu Glu Val Thr Trp Pro Glu Val Glu Val Pro Leu 
        35                  40                  45              


Asn Gly Thr Leu Ser Leu Ser Cys Val Ala Cys Ser Arg Phe Pro Asn 
    50                  55                  60                  


Phe Ser Ile Leu Tyr Trp Leu Gly Asn Gly Ser Phe Ile Glu His Leu 
65                  70                  75                  80  


Pro Gly Arg Leu Trp Glu Gly Ser Thr Ser Arg Glu Arg Gly Ser Thr 
                85                  90                  95      


Gly Thr Gln Leu Cys Lys Ala Leu Val Leu Glu Gln Leu Thr Pro Ala 
            100                 105                 110         


Leu His Ser Thr Asn Phe Ser Cys Val Leu Val Asp Pro Glu Gln Val 
        115                 120                 125             


Val Gln Arg His Val Val Leu Ala Gln Leu Trp Ala Gly Leu Arg Ala 
    130                 135                 140                 


Thr Leu Pro Pro Thr Gln Glu Ala Leu Pro Ser Ser His Ser Ser Pro 
145                 150                 155                 160 


Gln Gln Gln Gly 
                


<210>  8
<211>  492
<212>  DNA
<213>  Artificial

<220>
<223>  IL-18BP

<400>  8
acacctgtgt cccagaccac aacagccgct acagcttcag tgagatctac taaagatcct       60

tgtccttccc agccccctgt ttttcccgct gccaaacaat gtcctgctct tgaagttaca      120

tggccagagg tcgaggttcc acttaatgga acactcagcc tctcttgtgt ggcatgtagt      180

cgctttccca atttctcaat actttattgg ctcggaaatg gaagtttcat cgagcatttg      240

cctgggcggc tttgggaagg cagcactagc agagaacgcg gttcaacagg gacacagctc      300

tgtaaagccc tggtgctgga gcagttgact ccagcccttc actctactaa cttctcctgc      360

gttctcgtgg accctgagca agtggtccag aggcatgtag ttcttgcaca gctttgggcc      420

ggactgcgag caactctgcc acccactcag gaagccctcc caagtagcca ttctagccca      480

cagcagcaag gg                                                          492


<210>  9
<211>  492
<212>  DNA
<213>  Artificial

<220>
<223>  IL-18BP

<400>  9
accccagtgt cccaaaccac caccgcggct accgcctccg tccggtccac taaggatcct       60

tgcccgagcc agccgccggt gttccctgcc gcgaaacagt gccccgcact ggaagtgacc      120

tggcccgaag tggaagtccc cctcaatggt accctgagcc tctcatgcgt ggcatgctca      180

aggttcccga acttctcgat cctctactgg ctgggaaacg ggtcgttcat cgagcatctg      240

cccggacgcc tctgggaggg atccactagc cgcgagcgcg ggagcaccgg cacccagctg      300

tgcaaggcct tggtgcttga gcagctgact ccggccctgc actctacgaa cttctcctgc      360

gtgttggtgg accctgaaca agtggtgcag agacacgtcg tgctggccca gctctgggcc      420

gggctgcggg ccacactgcc gcccactcaa gaagccctgc caagctccca ctcgagccca      480

cagcagcagg gt                                                          492


<210>  10
<211>  223
<212>  PRT
<213>  Artificial

<220>
<223>  SL335H

<400>  10

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Pro Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Met Phe Arg Ala Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Gly Arg Tyr Ile His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Thr Val Met Ala Gly Lys Ala Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Glu Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Ser 
    210                 215                 220             


<210>  11
<211>  669
<212>  DNA
<213>  Artificial

<220>
<223>  SL335H

<400>  11
caagtgcaat tggtgcagtc aggtggcggc ccagtaaaac ccggtgggtc tctgagattg       60

agctgcgctg catccggatt tatgttccgt gcctacagca tgaattgggt gcggcaagct      120

cctggaaagg gactcgaatg ggtttccagt attagcagtt ctgggaggta tatacattat      180

gctgactcag tgaaagggag gttcacaatt agccgggaca atgccaaaaa ctctctctat      240

ctgcagatga acagccttcg cgccgaagat accgccgttt attactgcgc tcgggagact      300

gtgatggccg gtaaggctct tgactattgg ggacagggaa ctttggtgac tgtttcatct      360

gcctctacaa agggacccag cgtttttcca ttggcaccta gtagcaagtc cacatctgaa      420

ggtacagctg ctttggggtg tttggtgaaa gactacttcc ccgaaccagt gacagtttca      480

tggaactccg gcgctttgac tagtggagtg cataccttcc cagctgttct tcagagtagt      540

gggctttata gtttgagtag cgtcgtgact gtcccatcat cctctctcgg cacacaaacc      600

tatatctgca atgtaaacca taagccatca aacaccaaag tagacaagaa agttgagcca      660

aagtccagc                                                              669


<210>  12
<211>  669
<212>  DNA
<213>  Artificial

<220>
<223>  SL335H

<400>  12
caagtccagc ttgtgcagtc cggcggtgga ccagtgaagc ctgggggatc actgcgcctc       60

tcctgtgccg cttcggggtt catgttccgg gcatactcga tgaactgggt tagacaggct      120

cccggaaagg gcctggaatg ggtgtccagt atctcaagct cgggccgcta cattcattat      180

gcggacagcg tgaagggcag attcaccatt agccgggaca atgccaagaa ctccctgtac      240

ttgcaaatga actccctgag ggccgaggat actgcggtgt actattgtgc tcgggagact      300

gtgatggccg gaaaggccct ggactactgg ggccagggca cccttgtgac cgtgtcctcc      360

gcctcgacca agggaccgtc ggtgtttcct ctggcgccgt cctcgaagtc aacctccgag      420

ggaaccgccg ccctgggttg cctcgtgaaa gactacttcc ctgaacccgt gactgtgtcc      480

tggaacagcg gtgccctgac ctccggggtg catactttcc ctgcggtgct gcagtcgtcc      540

ggactctact ccctgtcatc cgtcgtgacc gtgccttcct cctccctggg aacccagacc      600

tacatctgca acgtgaacca caagccctcc aacaccaagg tcgacaagaa agtcgagccc      660

aagtccagc                                                              669


<210>  13
<211>  215
<212>  PRT
<213>  Artificial

<220>
<223>  SL335L

<400>  13

Asp Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Gly Ala Thr Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Phe Leu Ala 
                85                  90                  95      


Lys Thr Phe Gly Gln Gly Thr Gln Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Asn Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Ser 
    210                 215 


<210>  14
<211>  645
<212>  DNA
<213>  Artificial

<220>
<223>  SL335L

<400>  14
gacatcgtcc tgacccagag ccccgggaca ctgagcctgt cccccgggga gacagccaca       60

ctgagctgca gggccagcca gtccgtcggc tccaacctgg cctggtacca gcagaagccc      120

gggcaggccc ccaggctgct gatttacggc gccagcacag gcgccacagg ggtgcccgcc      180

aggtttagcg gcagccggag cggcacagat tttacactga caatcacatc cctgcagccc      240

gaggattttg ccacatacta ctgccagcag tactactcct tcctggccaa gacattcggc      300

cagggcaccc agctggagat caagcggacc gtggccgccc ccagcgtgtt tattttcccc      360

cccagcgatg agcagctgaa gtccggcacc gcctccgtcg tgtgcctgct gaacaacttc      420

tacccccggg aggccaaggt ccagtggaag gtcgataacg ccctgcagag cgggaactcc      480

caggagtccg tgaccgagca ggactccaag gacagcacct actccctgtc caacaccctg      540

accctgagca aggccgacta cgagaagcac aaggtctacg cctgcgaggt gacccaccag      600

ggcctgtcct cccccgtgac caagagcttt aaccgggggg agtcc                      645


<210>  15
<211>  645
<212>  DNA
<213>  Artificial

<220>
<223>  SL335L

<400>  15
gatatcgtgc tgactcagtc gcctggtacc ctttccctgt cacccggaga aactgccacc       60

ctgagctgta gagcgagcca gtccgtgggc tccaacctgg cctggtatca acagaagcct      120

gggcaggccc ctcgcctgtt gatctacggc gccagcactg gtgccaccgg cgtgccagct      180

cggttctccg gctcccggtc ggggactgac ttcaccctca ccattacgag cctgcagccc      240

gaagatttcg cgacctacta ctgccaacag tactactcat tcctggctaa gactttcgga      300

caaggcaccc agctcgagat caagcggacc gtggcagcac cgtccgtgtt cattttcccg      360

ccgtccgacg agcaacttaa gtccggaacc gcctctgtcg tgtgcctcct caacaacttc      420

tacccgcgcg aggccaaggt ccagtggaag gtcgacaacg cgctgcagtc cggaaattca      480

caggaaagcg tgaccgaaca ggactccaag gattcgacct actccctgtc caacactctg      540

accctgtcga aagccgacta cgagaagcac aaagtgtacg cctgcgaagt gacacatcag      600

ggactcagct cgcccgtgac caagagcttc aacaggggag agtcg                      645


<210>  16
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Linker 1

<400>  16

Gly Ser Ala Pro Ala Pro Gly Ser 
1               5               


<210>  17
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Linker 1

<400>  17
gggtcagccc ctgccccagg tagc                                              24


<210>  18
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Linker 1

<400>  18
ggctcggccc cggcaccggg cagc                                              24


<210>  19
<211>  395
<212>  PRT
<213>  Artificial

<220>
<223>  SL335H + peptide linker + IL-18BP

<400>  19

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Pro Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Met Phe Arg Ala Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Gly Arg Tyr Ile His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Thr Val Met Ala Gly Lys Ala Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Glu Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Ser Gly 
    210                 215                 220                 


Ser Ala Pro Ala Pro Gly Ser Thr Pro Val Ser Gln Thr Thr Thr Ala 
225                 230                 235                 240 


Ala Thr Ala Ser Val Arg Ser Thr Lys Asp Pro Cys Pro Ser Gln Pro 
                245                 250                 255     


Pro Val Phe Pro Ala Ala Lys Gln Cys Pro Ala Leu Glu Val Thr Trp 
            260                 265                 270         


Pro Glu Val Glu Val Pro Leu Asn Gly Thr Leu Ser Leu Ser Cys Val 
        275                 280                 285             


Ala Cys Ser Arg Phe Pro Asn Phe Ser Ile Leu Tyr Trp Leu Gly Asn 
    290                 295                 300                 


Gly Ser Phe Ile Glu His Leu Pro Gly Arg Leu Trp Glu Gly Ser Thr 
305                 310                 315                 320 


Ser Arg Glu Arg Gly Ser Thr Gly Thr Gln Leu Cys Lys Ala Leu Val 
                325                 330                 335     


Leu Glu Gln Leu Thr Pro Ala Leu His Ser Thr Asn Phe Ser Cys Val 
            340                 345                 350         


Leu Val Asp Pro Glu Gln Val Val Gln Arg His Val Val Leu Ala Gln 
        355                 360                 365             


Leu Trp Ala Gly Leu Arg Ala Thr Leu Pro Pro Thr Gln Glu Ala Leu 
    370                 375                 380                 


Pro Ser Ser His Ser Ser Pro Gln Gln Gln Gly 
385                 390                 395 


<210>  20
<211>  1185
<212>  DNA
<213>  Artificial

<220>
<223>  SL335H + peptide linker + IL-18BP

<400>  20
caagtgcaat tggtgcagtc aggtggcggc ccagtaaaac ccggtgggtc tctgagattg       60

agctgcgctg catccggatt tatgttccgt gcctacagca tgaattgggt gcggcaagct      120

cctggaaagg gactcgaatg ggtttccagt attagcagtt ctgggaggta tatacattat      180

gctgactcag tgaaagggag gttcacaatt agccgggaca atgccaaaaa ctctctctat      240

ctgcagatga acagccttcg cgccgaagat accgccgttt attactgcgc tcgggagact      300

gtgatggccg gtaaggctct tgactattgg ggacagggaa ctttggtgac tgtttcatct      360

gcctctacaa agggacccag cgtttttcca ttggcaccta gtagcaagtc cacatctgaa      420

ggtacagctg ctttggggtg tttggtgaaa gactacttcc ccgaaccagt gacagtttca      480

tggaactccg gcgctttgac tagtggagtg cataccttcc cagctgttct tcagagtagt      540

gggctttata gtttgagtag cgtcgtgact gtcccatcat cctctctcgg cacacaaacc      600

tatatctgca atgtaaacca taagccatca aacaccaaag tagacaagaa agttgagcca      660

aagtccagcg ggtcagcccc tgccccaggt agcacacctg tgtcccagac cacaacagcc      720

gctacagctt cagtgagatc tactaaagat ccttgtcctt cccagccccc tgtttttccc      780

gctgccaaac aatgtcctgc tcttgaagtt acatggccag aggtcgaggt tccacttaat      840

ggaacactca gcctctcttg tgtggcatgt agtcgctttc ccaatttctc aatactttat      900

tggctcggaa atggaagttt catcgagcat ttgcctgggc ggctttggga aggcagcact      960

agcagagaac gcggttcaac agggacacag ctctgtaaag ccctggtgct ggagcagttg     1020

actccagccc ttcactctac taacttctcc tgcgttctcg tggaccctga gcaagtggtc     1080

cagaggcatg tagttcttgc acagctttgg gccggactgc gagcaactct gccacccact     1140

caggaagccc tcccaagtag ccattctagc ccacagcagc aaggg                     1185


<210>  21
<211>  1185
<212>  DNA
<213>  Artificial

<220>
<223>  SL335H + peptide linker + IL-18BP

<400>  21
caagtccagc ttgtgcagtc cggcggtgga ccagtgaagc ctgggggatc actgcgcctc       60

tcctgtgccg cttcggggtt catgttccgg gcatactcga tgaactgggt tagacaggct      120

cccggaaagg gcctggaatg ggtgtccagt atctcaagct cgggccgcta cattcattat      180

gcggacagcg tgaagggcag attcaccatt agccgggaca atgccaagaa ctccctgtac      240

ttgcaaatga actccctgag ggccgaggat actgcggtgt actattgtgc tcgggagact      300

gtgatggccg gaaaggccct ggactactgg ggccagggca cccttgtgac cgtgtcctcc      360

gcctcgacca agggaccgtc ggtgtttcct ctggcgccgt cctcgaagtc aacctccgag      420

ggaaccgccg ccctgggttg cctcgtgaaa gactacttcc ctgaacccgt gactgtgtcc      480

tggaacagcg gtgccctgac ctccggggtg catactttcc ctgcggtgct gcagtcgtcc      540

ggactctact ccctgtcatc cgtcgtgacc gtgccttcct cctccctggg aacccagacc      600

tacatctgca acgtgaacca caagccctcc aacaccaagg tcgacaagaa agtcgagccc      660

aagtccagcg gctcggcccc ggcaccgggc agcaccccag tgtcccaaac caccaccgcg      720

gctaccgcct ccgtccggtc cactaaggat ccttgcccga gccagccgcc ggtgttccct      780

gccgcgaaac agtgccccgc actggaagtg acctggcccg aagtggaagt ccccctcaat      840

ggtaccctga gcctctcatg cgtggcatgc tcaaggttcc cgaacttctc gatcctctac      900

tggctgggaa acgggtcgtt catcgagcat ctgcccggac gcctctggga gggatccact      960

agccgcgagc gcgggagcac cggcacccag ctgtgcaagg ccttggtgct tgagcagctg     1020

actccggccc tgcactctac gaacttctcc tgcgtgttgg tggaccctga acaagtggtg     1080

cagagacacg tcgtgctggc ccagctctgg gccgggctgc gggccacact gccgcccact     1140

caagaagccc tgccaagctc ccactcgagc ccacagcagc agggt                     1185


<210>  22
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable domain CDR1

<400>  22

Ser Tyr Gly Ile Ser 
1               5   


<210>  23
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable domain CDR2

<400>  23

Trp Ile Asn Thr Tyr Ser Gly Gly Thr Lys Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  24
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable domain CDR3

<400>  24

Leu Gly His Cys Gln Arg Gly Ile Cys Ser Asp Ala Leu Asp Thr 
1               5                   10                  15  


<210>  25
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable domain CDR2

<400>  25

Arg Ile Asn Thr Tyr Asn Gly Asn Thr Gly Tyr Ala Gln Arg Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  26
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable domain CDR1

<400>  26

Asn Tyr Gly Ile His 
1               5   


<210>  27
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable domain CDR2

<400>  27

Ser Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  28
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable domain CDR3

<400>  28

Asp Val His Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Ala Phe Asp Ile 
1               5                   10                  15      


<210>  29
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable domain CDR1

<400>  29

Ser Tyr Ala Met Ser 
1               5   


<210>  30
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable domain CDR2

<400>  30

Val Ile Ser His Asp Gly Gly Phe Gln Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  31
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable domain CDR3

<400>  31

Ala Gly Trp Leu Arg Gln Tyr Gly Met Asp Val 
1               5                   10      


<210>  32
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable domain CDR1

<400>  32

Ala Tyr Trp Ile Ala 
1               5   


<210>  33
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable domain CDR2

<400>  33

Met Ile Trp Pro Pro Asp Ala Asp Ala Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  34
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable domain CDR3

<400>  34

Leu Tyr Ser Gly Ser Tyr Ser Pro 
1               5               


<210>  35
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable domain CDR1

<400>  35

Ala Tyr Ser Met Asn 
1               5   


<210>  36
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable domain CDR2

<400>  36

Ser Ile Ser Ser Ser Gly Arg Tyr Ile His Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  37
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable domain CDR3

<400>  37

Glu Thr Val Met Ala Gly Lys Ala Leu Asp Tyr 
1               5                   10      


<210>  38
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable domain CDR1

<400>  38

Arg Ala Ser Gln Ser Ile Ser Arg Tyr Leu Asn 
1               5                   10      


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable domain CDR2

<400>  39

Gly Ala Ser Arg Leu Glu Ser 
1               5           


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable domain CDR3

<400>  40

Gln Gln Ser Asp Ser Val Pro Val Thr 
1               5                   


<210>  41
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable domain CDR1

<400>  41

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  42
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable domain CDR2

<400>  42

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  43
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable domain CDR3

<400>  43

Gln Gln Ser Tyr Ser Thr Pro Pro Tyr Thr 
1               5                   10  


<210>  44
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable domain CDR1

<400>  44

Arg Ala Ser Gln Ser Ile Phe Asn Tyr Val Ala 
1               5                   10      


<210>  45
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable domain CDR2

<400>  45

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  46
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable domain CDR3

<400>  46

Gln Gln Arg Ser Lys Trp Pro Pro Thr Trp Thr 
1               5                   10      


<210>  47
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable domain CDR1

<400>  47

Arg Ala Ser Glu Thr Val Ser Ser Arg Gln Leu Ala 
1               5                   10          


<210>  48
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable domain CDR2

<400>  48

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  49
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable domain CDR3

<400>  49

Gln Gln Tyr Gly Ser Ser Pro Arg Thr 
1               5                   


<210>  50
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable domain CDR1

<400>  50

Arg Ala Ser Gln Ser Val Ser Ser Ser Ser Leu Ala 
1               5                   10          


<210>  51
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable domain CDR3

<400>  51

Gln Lys Tyr Ser Ser Tyr Pro Leu Thr 
1               5                   


<210>  52
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable domain CDR1

<400>  52

Arg Ala Ser Gln Ser Val Gly Ser Asn Leu Ala 
1               5                   10      


<210>  53
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable domain CDR2

<400>  53

Gly Ala Ser Thr Gly Ala Thr 
1               5           


<210>  54
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable domain CDR3

<400>  54

Gln Gln Tyr Tyr Ser Phe Leu Ala Lys Thr 
1               5                   10  


<210>  55
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable domain 1

<400>  55

Gln Val Gln Leu Leu Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Ser Gly Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Gly Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly His Cys Gln Arg Gly Ile Cys Ser Asp Ala Leu Asp 
            100                 105                 110         


Thr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  56
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable domain 2

<400>  56

Glu Val Gln Leu Leu Gln Ser Gly Ala Glu Val Lys Glu Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Asn Thr Tyr Asn Gly Asn Thr Gly Tyr Ala Gln Arg Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Ile Ala Tyr 
65                  70                  75                  80  


Met Glu Val Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly His Cys Gln Arg Gly Ile Cys Ser Asp Ala Leu Asp 
            100                 105                 110         


Thr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 


<210>  57
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable domain 3

<400>  57

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asn Tyr 
            20                  25                  30          


Gly Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Asn Thr Val His 
65                  70                  75                  80  


Val Gln Met Asp Ser Leu Arg Gly Gly Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val His Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  58
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable domain 4

<400>  58

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ser Val Ile Ser His Asp Gly Gly Phe Gln Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gly Trp Leu Arg Gln Tyr Gly Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  59
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable domain 5

<400>  59

Glu Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Ile Ser Gly Tyr Ser Phe Thr Ala Tyr 
            20                  25                  30          


Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Ile Trp Pro Pro Asp Ala Asp Ala Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Phe Ser Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp His Ser Leu Lys Thr Ser Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Tyr Ser Gly Ser Tyr Ser Pro Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  60
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable domain 6

<400>  60

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Pro Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Met Phe Arg Ala Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Gly Arg Tyr Ile His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Thr Val Met Ala Gly Lys Ala Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  61
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable domain 1

<400>  61

Glu Leu Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Arg Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asp Ser Val Pro Val 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
            100                 105             


<210>  62
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable domain 2

<400>  62

Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 


<210>  63
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable domain 3

<400>  63

Glu Leu Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Phe Asn Tyr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Lys Trp Pro Pro 
                85                  90                  95      


Thr Trp Thr Phe Gly Gln Gly Thr Arg Val Asp Ile Lys Arg 
            100                 105                 110 


<210>  64
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable domain 4

<400>  64

Glu Leu Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Thr Val Ser Ser Arg 
            20                  25                  30          


Gln Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Ser Ala Val Phe Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 


<210>  65
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable domain 5

<400>  65

Glu Leu Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Lys Tyr Ser Ser Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 


<210>  66
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable domain 6

<400>  66

Glu Leu Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Gly Ala Thr Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Phe Leu Ala 
                85                  90                  95      


Lys Thr Phe Gly Gln Gly Thr Gln Leu Glu Ile Lys Arg 
            100                 105                 


<210>  67
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable domain 7

<400>  67

Asp Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Gly Ala Thr Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Phe Leu Ala 
                85                  90                  95      


Lys Thr Phe Gly Gln Gly Thr Gln Leu Glu Ile Lys Arg 
            100                 105                 


<210>  68
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain constant domain

<400>  68

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Glu Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Ser 
            100             


<210>  69
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain constant domain

<400>  69

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Asn Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Ser 
            100                 105         


<210>  70
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 2

<400>  70

Gly Ser Ala Gly Ser Ala Pro Ala Pro Ala Gly Ser Gly Glu Phe 
1               5                   10                  15  


<210>  71
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3

<400>  71

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  72
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 4

<400>  72

Gly Gly Gly Gly Ser 
1               5   


<210>  73
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 5

<400>  73

Ser Gly Gly Gly Gly 
1               5   


<210>  74
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 6

<400>  74

Ser Arg Ser Ser Gly 
1               5   


<210>  75
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 7

<400>  75

Ser Gly Ser Ser Cys 
1               5   


<210>  76
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 8

<400>  76

Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser 
1               5                   10          


<210>  77
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 9

<400>  77

Arg Pro Pro Pro Pro Cys 
1               5       


<210>  78
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 10

<400>  78

Ser Ser Pro Pro Pro Pro Cys 
1               5           


<210>  79
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 11

<400>  79

Gly Ser Thr Ser Gly Ser Gly Lys Ser Ser Glu Gly Lys Gly 
1               5                   10                  


<210>  80
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 12

<400>  80

Gly Ser Thr Ser Gly Ser Gly Lys Ser Ser Glu Gly Ser Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  81
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 13

<400>  81

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  82
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 14

<400>  82

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Glu Phe 
1               5                   10                  


<210>  83
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 15

<400>  83

Gly Ser Ala Gly Ser Ala Pro Ala Pro Ala Gly Ser Gly Glu Phe 
1               5                   10                  15  


<210>  84
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 16

<400>  84

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  85
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Histidine tag

<400>  85

His His His His His His His His 
1               5               


