                         SEQUENCE LISTING

<110>  CRISPR THERAPEUTICS AG
 
<120>  MATERIALS AND METHODS FOR TREATMENT OF AMYOTROPHIC LATERAL 
       SCLEROSIS

<130>  33165/CT145

<160>  45    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  1
tgtgcgaacc ttaatagggg                                                   20


<210>  2
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  2
ccaagcgtca tcttttacgt                                                   20


<210>  3
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  3
gcgtgtgcga accttaatag                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  4
tgctctcaca gtactcgctg                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  5
cgccaacgct cctccagagc                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  6
ggttgcggtg cctgcgcccg                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  7
tgcggtgcct gcgcccgcgg                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  8
gacccgctct ggaggagcgt                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  9
gtactgtgag agcaagtagt                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  10
acagagtaga cccttggttg                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  11
ggttttgtac agtcccctct                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  12
atcctggcgg gtggctgttt                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  13
ctttcgcctc tagcgactgg                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  14
ggcttctgcg gaccaagtcg                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  artificial sequencre

<220>
<223>  Synthetic

<400>  15
gaactcagga gtcgcgcgct                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  16
gcgaggcctc tcagtacccg                                                   20


<210>  17
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  17
cgaaccttaa taggggaggc tg                                                22


<210>  18
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  18
cttgctctca cagtactcgc tg                                                22


<210>  19
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  19
ctgcccggtt gcttctcttt tg                                                22


<210>  20
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  20
ttcttttatc ttaagacccg ct                                                22


<210>  21
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  21
acttgctctc acagtactcg ct                                                22


<210>  22
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  22
ctagcaagag caggtgtggg tt                                                22


<210>  23
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  23
attgcgccaa cgctcctcca ga                                                22


<210>  24
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  24
gagtactgtg agagcaagta gt                                                22


<210>  25
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  25
gaagacgatt tcgtggtttt ga                                                22


<210>  26
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  26
ttttatctta agacccgctc tg                                                22


<210>  27
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  27
taagacccgc tctggaggag cg                                                22


<210>  28
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  28
cggggtctag caagagcagg tg                                                22


<210>  29
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  29
ttgcgccaac gctcctccag ag                                                22


<210>  30
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  30
gcggggtcta gcaagagcag gt                                                22


<210>  31
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  31
ttaatagggg aggctgctgg at                                                22


<210>  32
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  32
acaccaagcg tcatctttta cg                                                22


<210>  33
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  33
ccgcccacgt aaaagatgac gc                                                22


<210>  34
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  34
gcgagtactg tgagagcaag ta                                                22


<210>  35
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  35
acttgctctc acagtactcg ct                                                22


<210>  36
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  36
agcgggtctt aagataaaag aa                                                22


<210>  37
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Sythetic

<400>  37
ccaagcgtca tcttttacgt gg                                                22


<210>  38
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  38
cacaccaagc gtcatctttt ac                                                22


<210>  39
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  39
cccggttgct tctcttttgg gg                                                22


<210>  40
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  40
gcggggtcta gcaagagcag gt                                                22


<210>  41
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  41
gcgtgtgcga accttaatag gg                                                22


<210>  42
<211>  2900
<212>  DNA
<213>  Homo sapiens

<400>  42
tcaggtgaga cttgggactt tggacttttg aatgaatgct ggatcgagtt aagactttgg       60

ggaactgttg gtaaggcacg acagtatttt gcaatatgag aaggacatta gatttgggag      120

gggccagagt tggaataaca tggtttggat ctctgtcccc acccaaatct catgttcaac      180

tgtaatcccc agtgttggag gttgggcctg gtgggaggtg agtggattat ggggtggctt      240

ctaatggttt tgtacagtcc cctcttggta ctatatagtg agttctgaca agatctagtt      300

gtttaaacgt atgtagcacc tcccatttct ctcttccccc agttcctgcc atgtgaagtc      360

tggggtctcc ctatgccttc catcatgatt ttaagttccc tatggcctgc ccagaagctg      420

atccagccat gcttcttgta cagcctgcag aactgtgagc cattaaactt ttctttataa      480

attacccagt ttcagttatt tctttatagc agtgtaagaa tggactaaca caattattaa      540

cgctagtcct catgttgtac attaaatctc tagatgtatt agacgtaact gcaactttgt      600

accctaccct acaattttct ttccccccaa gccccccaac caagggtcta ctctgtttct      660

ataaattcag ttgtttttta attccacgta taagtgaagt acaactcagt gtagaaactt      720

ggtaaatgct agctacttgt tataagctgt cagtcaaaat aaaaatacag agatgaatct      780

ctaaattaag tgatttattt gggaagaaag aattgcaatt agggcataca tgtagatcag      840

atggtcttcg gtatatccac acaacaaaga aaagggggag gttttgttaa aaaagagaaa      900

tgttacatag tgctctttga gaaaattcat tggcactatt aaggatctga ggagctggtg      960

agtttcaact ggtgagtgat ggtggtagat aaaattagag ctgcagcagg tcattttagc     1020

aactattaga taaaactggt ctcaggtcac aacgggcagt tgcagcagct ggacttggag     1080

agaattacac tgtgggagca gtgtcatttg tcctaagtgc ttttctaccc cctaccccca     1140

ctattttagt tgggtataaa aagaatgacc caatttgtat gatcaacttt cacaaagcat     1200

agaacagtag gaaaagggtc tgtttctgca gaaggtgtag acgttgagag ccattttgtg     1260

tatttattcc tccctttctt cctcggtgaa tgattaaaac gttctgtgtg atttttagtg     1320

atgaaaaaga ttaaatgcta ctcactgtag taagtgccat ctcacacttg cagatcaaaa     1380

ggcacacagt ttaaaaaacc tttgtttttt tacacatctg agtggtgtaa atgctactca     1440

tctgtagtaa gtggaatcta tacacctgca gaccaaaaga cgcaaggttt caaaaatctt     1500

tgtgtttttt acacatcaaa cagaatggta cgtttttcaa aagttaaaaa aaaacaactc     1560

atccacatat tgcaactagc aaaaatgaca ttccccagtg tgaaaatcat gcttgagaga     1620

attcttacat gtaaaggcaa aattgcgatg actttgcagg ggaccgtggg attcccgccc     1680

gcagtgccgg agctgtcccc taccagggtt tgcagtggag ttttgaatgc acttaacagt     1740

gtcttacggt aaaaacaaaa tttcatccac caattatgtg ttgagcgccc actgcctacc     1800

aagcacaaac aaaaccattc aaaaccacga aatcgtcttc actttctcca gatccagcag     1860

cctcccctat taaggttcgc acacgctatt gcgccaacgc tcctccagag cgggtcttaa     1920

gataaaagaa caggacaagt tgccccgccc catttcgcta gcctcgtgag aaaacgtcat     1980

cgcacataga aaacagacag acgtaaccta cggtgtcccg ctaggaaaga gaggtgcgtc     2040

aaacagcgac aagttccgcc cacgtaaaag atgacgcttg gtgtgtcagc cgtccctgct     2100

gcccggttgc ttctcttttg ggggcggggt ctagcaagag caggtgtggg tttaggaggt     2160

gtgtgttttt gtttttccca ccctctctcc ccactacttg ctctcacagt actcgctgag     2220

ggtgaacaag aaaagacctg ataaagatta accagaagaa aacaaggagg gaaacaaccg     2280

cagcctgtag caagctctgg aactcaggag tcgcgcgcta ggggccgggg ccggggccgg     2340

ggcgtggtcg gggcgggccc gggggcgggc ccggggcggg gctgcggttg cggtgcctgc     2400

gcccgcggcg gcggaggcgc aggcggtggc gagtgggtga gtgaggaggc ggcatcctgg     2460

cgggtggctg tttggggttc ggctgccggg aagaggcgcg ggtagaagcg ggggctctcc     2520

tcagagctcg acgcattttt actttccctc tcatttctct gaccgaagct gggtgtcggg     2580

ctttcgcctc tagcgactgg tggaattgcc tgcatccggg ccccgggctt cccggcggcg     2640

gcggcggcgg cggcggcgca gggacaaggg atggggatct ggcctcttcc ttgctttccc     2700

gccctcagta cccgagctgt ctccttcccg gggacccgct gggagcgctg ccgctgcggg     2760

ctcgagaaaa gggagcctcg ggtactgaga ggcctcgcct gggggaaggc cggagggtgg     2820

gcggcgcgcg gcttctgcgg accaagtcgg ggttcgctag gaacccgaga cggtccctgc     2880

cggcgaggag atcatgcggg                                                 2900


<210>  43
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  43
gctagcctcg tgagaaaacg                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  44
ctctttccta gcgggacacc                                                   20


<210>  45
<211>  25
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic

<400>  45
catcgcacat agaaaacaga cagac                                             25


