                         SEQUENCE LISTING

<110>  GENMAB A/S
 
<120>  ANTIBODIES CAPABLE OF BINDING TO ROR2 AND BISPECIFIC ANTIBODIES 
       BINDING TO ROR2 AND CD3

<130>  P/159-WO-PCT

<160>  51    

<170>  PatentIn version 3.5

<210>  1
<211>  943
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SITE
<222>  (1)..(943)
<223>  Human ROR2

<400>  1

Met Ala Arg Gly Ser Ala Leu Pro Arg Arg Pro Leu Leu Cys Ile Pro 
1               5                   10                  15      


Ala Val Trp Ala Ala Ala Ala Leu Leu Leu Ser Val Ser Arg Thr Ser 
            20                  25                  30          


Gly Glu Val Glu Val Leu Asp Pro Asn Asp Pro Leu Gly Pro Leu Asp 
        35                  40                  45              


Gly Gln Asp Gly Pro Ile Pro Thr Leu Lys Gly Tyr Phe Leu Asn Phe 
    50                  55                  60                  


Leu Glu Pro Val Asn Asn Ile Thr Ile Val Gln Gly Gln Thr Ala Ile 
65                  70                  75                  80  


Leu His Cys Lys Val Ala Gly Asn Pro Pro Pro Asn Val Arg Trp Leu 
                85                  90                  95      


Lys Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Ile Ile Ile Arg 
            100                 105                 110         


Lys Thr Glu Tyr Gly Ser Arg Leu Arg Ile Gln Asp Leu Asp Thr Thr 
        115                 120                 125             


Asp Thr Gly Tyr Tyr Gln Cys Val Ala Thr Asn Gly Met Lys Thr Ile 
    130                 135                 140                 


Thr Ala Thr Gly Val Leu Phe Val Arg Leu Gly Pro Thr His Ser Pro 
145                 150                 155                 160 


Asn His Asn Phe Gln Asp Asp Tyr His Glu Asp Gly Phe Cys Gln Pro 
                165                 170                 175     


Tyr Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Ile Tyr 
            180                 185                 190         


Val Asp Ser Leu Gln Met Gln Gly Glu Ile Glu Asn Arg Ile Thr Ala 
        195                 200                 205             


Ala Phe Thr Met Ile Gly Thr Ser Thr His Leu Ser Asp Gln Cys Ser 
    210                 215                 220                 


Gln Phe Ala Ile Pro Ser Phe Cys His Phe Val Phe Pro Leu Cys Asp 
225                 230                 235                 240 


Ala Arg Ser Arg Thr Pro Lys Pro Arg Glu Leu Cys Arg Asp Glu Cys 
                245                 250                 255     


Glu Val Leu Glu Ser Asp Leu Cys Arg Gln Glu Tyr Thr Ile Ala Arg 
            260                 265                 270         


Ser Asn Pro Leu Ile Leu Met Arg Leu Gln Leu Pro Lys Cys Glu Ala 
        275                 280                 285             


Leu Pro Met Pro Glu Ser Pro Asp Ala Ala Asn Cys Met Arg Ile Gly 
    290                 295                 300                 


Ile Pro Ala Glu Arg Leu Gly Arg Tyr His Gln Cys Tyr Asn Gly Ser 
305                 310                 315                 320 


Gly Met Asp Tyr Arg Gly Thr Ala Ser Thr Thr Lys Ser Gly His Gln 
                325                 330                 335     


Cys Gln Pro Trp Ala Leu Gln His Pro His Ser His His Leu Ser Ser 
            340                 345                 350         


Thr Asp Phe Pro Glu Leu Gly Gly Gly His Ala Tyr Cys Arg Asn Pro 
        355                 360                 365             


Gly Gly Gln Met Glu Gly Pro Trp Cys Phe Thr Gln Asn Lys Asn Val 
    370                 375                 380                 


Arg Met Glu Leu Cys Asp Val Pro Ser Cys Ser Pro Arg Asp Ser Ser 
385                 390                 395                 400 


Lys Met Gly Ile Leu Tyr Ile Leu Val Pro Ser Ile Ala Ile Pro Leu 
                405                 410                 415     


Val Ile Ala Cys Leu Phe Phe Leu Val Cys Met Cys Arg Asn Lys Gln 
            420                 425                 430         


Lys Ala Ser Ala Ser Thr Pro Gln Arg Arg Gln Leu Met Ala Ser Pro 
        435                 440                 445             


Ser Gln Asp Met Glu Met Pro Leu Ile Asn Gln His Lys Gln Ala Lys 
    450                 455                 460                 


Leu Lys Glu Ile Ser Leu Ser Ala Val Arg Phe Met Glu Glu Leu Gly 
465                 470                 475                 480 


Glu Asp Arg Phe Gly Lys Val Tyr Lys Gly His Leu Phe Gly Pro Ala 
                485                 490                 495     


Pro Gly Glu Gln Thr Gln Ala Val Ala Ile Lys Thr Leu Lys Asp Lys 
            500                 505                 510         


Ala Glu Gly Pro Leu Arg Glu Glu Phe Arg His Glu Ala Met Leu Arg 
        515                 520                 525             


Ala Arg Leu Gln His Pro Asn Val Val Cys Leu Leu Gly Val Val Thr 
    530                 535                 540                 


Lys Asp Gln Pro Leu Ser Met Ile Phe Ser Tyr Cys Ser His Gly Asp 
545                 550                 555                 560 


Leu His Glu Phe Leu Val Met Arg Ser Pro His Ser Asp Val Gly Ser 
                565                 570                 575     


Thr Asp Asp Asp Arg Thr Val Lys Ser Ala Leu Glu Pro Pro Asp Phe 
            580                 585                 590         


Val His Leu Val Ala Gln Ile Ala Ala Gly Met Glu Tyr Leu Ser Ser 
        595                 600                 605             


His His Val Val His Lys Asp Leu Ala Thr Arg Asn Val Leu Val Tyr 
    610                 615                 620                 


Asp Lys Leu Asn Val Lys Ile Ser Asp Leu Gly Leu Phe Arg Glu Val 
625                 630                 635                 640 


Tyr Ala Ala Asp Tyr Tyr Lys Leu Leu Gly Asn Ser Leu Leu Pro Ile 
                645                 650                 655     


Arg Trp Met Ala Pro Glu Ala Ile Met Tyr Gly Lys Phe Ser Ile Asp 
            660                 665                 670         


Ser Asp Ile Trp Ser Tyr Gly Val Val Leu Trp Glu Val Phe Ser Tyr 
        675                 680                 685             


Gly Leu Gln Pro Tyr Cys Gly Tyr Ser Asn Gln Asp Val Val Glu Met 
    690                 695                 700                 


Ile Arg Asn Arg Gln Val Leu Pro Cys Pro Asp Asp Cys Pro Ala Trp 
705                 710                 715                 720 


Val Tyr Ala Leu Met Ile Glu Cys Trp Asn Glu Phe Pro Ser Arg Arg 
                725                 730                 735     


Pro Arg Phe Lys Asp Ile His Ser Arg Leu Arg Ala Trp Gly Asn Leu 
            740                 745                 750         


Ser Asn Tyr Asn Ser Ser Ala Gln Thr Ser Gly Ala Ser Asn Thr Thr 
        755                 760                 765             


Gln Thr Ser Ser Leu Ser Thr Ser Pro Val Ser Asn Val Ser Asn Ala 
    770                 775                 780                 


Arg Tyr Val Gly Pro Lys Gln Lys Ala Pro Pro Phe Pro Gln Pro Gln 
785                 790                 795                 800 


Phe Ile Pro Met Lys Gly Gln Ile Arg Pro Met Val Pro Pro Pro Gln 
                805                 810                 815     


Leu Tyr Val Pro Val Asn Gly Tyr Gln Pro Val Pro Ala Tyr Gly Ala 
            820                 825                 830         


Tyr Leu Pro Asn Phe Tyr Pro Val Gln Ile Pro Met Gln Met Ala Pro 
        835                 840                 845             


Gln Gln Val Pro Pro Gln Met Val Pro Lys Pro Ser Ser His His Ser 
    850                 855                 860                 


Gly Ser Gly Ser Thr Ser Thr Gly Tyr Val Thr Thr Ala Pro Ser Asn 
865                 870                 875                 880 


Thr Ser Met Ala Asp Arg Ala Ala Leu Leu Ser Glu Gly Ala Asp Asp 
                885                 890                 895     


Thr Gln Asn Ala Pro Glu Asp Gly Ala Gln Ser Thr Val Gln Glu Ala 
            900                 905                 910         


Glu Glu Glu Glu Glu Gly Ser Val Pro Glu Thr Glu Leu Leu Gly Asp 
        915                 920                 925             


Cys Asp Thr Leu Gln Val Asp Glu Ala Gln Val Gln Leu Glu Ala 
    930                 935                 940             


<210>  2
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ROR2-A_VH

<400>  2

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Ser 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Val Ile Tyr Val Asn Ser Lys Thr Trp Tyr Ala Asn Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Asp 
                85                  90                  95      


Ala Gly Tyr Thr Thr Asn Ser Trp Leu Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  3
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ROR2-A_VH-CDR1

<400>  3

Gly Phe Ser Leu Ser Ser Tyr Ser 
1               5               


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ROR2-A_VH-CDR2

<400>  4

Ile Tyr Val Asn Ser Lys Thr 
1               5           


<210>  5
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ROR2-A_VH-CDR3

<400>  5

Ala Arg Gly Asp Ala Gly Tyr Thr Thr Asn Ser Trp Leu 
1               5                   10              


<210>  6
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ROR2-A_VL

<400>  6

Ala Phe Glu Leu Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Ser Ile Asp Asn Tyr 
            20                  25                  30          


Cys Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gln Ala Phe Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu Glu Ser 
65                  70                  75                  80  


Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Ser Gly Ile Ser Thr 
                85                  90                  95      


Thr Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105             


<210>  7
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ROR2-A_VL-CDR1

<400>  7

Glu Ser Ile Asp Asn Tyr 
1               5       


<210>  8
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ROR2-A_VL-CDR2

<400>  8

Gln Ala Phe 
1           


<210>  9
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ROR2-A_VL-CDR3

<400>  9

Gln Ser Tyr Ser Gly Ile Ser Thr Thr Ala 
1               5                   10  


<210>  10
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ROR2-A_ HC1

<400>  10

Gln Ser Val Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Ser 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Val Ile Tyr Val Asn Ser Lys Thr Trp Tyr Ala Asn Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Asp 
                85                  90                  95      


Ala Gly Tyr Thr Thr Asn Ser Trp Leu Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  11
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ROR2-A_ HC2

<400>  11

Gln Ser Val Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Ser 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Val Ile Tyr Val Asn Ser Lys Thr Trp Tyr Ala Asn Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Tyr Leu Gln Met Asn 
65                  70                  75                  80  


Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Asp 
                85                  90                  95      


Ala Gly Tyr Thr Thr Asn Ser Trp Leu Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  12
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ROR2-A_ HC3

<400>  12

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Tyr Val Asn Ser Lys Thr Trp Tyr Ala Asn Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Tyr Leu Gln Met 
65                  70                  75                  80  


Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Gly 
                85                  90                  95      


Asp Ala Gly Tyr Thr Thr Asn Ser Trp Leu Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  13
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ROR2-A_ HC4

<400>  13

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Tyr Val Asn Ser Lys Thr Trp Tyr Ala Asn Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Asp Ala Gly Tyr Thr Thr Asn Ser Trp Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  14
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ROR2-A_ HC5

<400>  14

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Tyr Val Asn Ser Lys Thr Trp Tyr Ala Asn Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Asp Ala Gly Tyr Thr Thr Asn Ser Trp Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  15
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ROR2-A_ HC6

<400>  15

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Tyr Val Asn Ser Lys Thr Trp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Asp Ala Gly Tyr Thr Thr Asn Ser Trp Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  16
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ROR2-A_ HC7

<400>  16

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Tyr Val Asn Ser Lys Thr Trp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Asp Ala Gly Tyr Thr Thr Asn Ser Trp Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  17
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ROR2-A_ LC1

<400>  17

Ala Phe Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Asp Asn Tyr 
            20                  25                  30          


Cys Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gln Ala Phe Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Tyr Ser Gly Ile Ser Thr 
                85                  90                  95      


Thr Ala Phe Gly Gly Gly Thr Glu Val Val Ile Lys 
            100                 105             


<210>  18
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ROR2-A_ LC2

<400>  18

Ala Phe Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Asp Asn Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gln Ala Phe Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Tyr Ser Gly Ile Ser Thr 
                85                  90                  95      


Thr Ala Phe Gly Gly Gly Thr Glu Val Val Ile Lys 
            100                 105             


<210>  19
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ROR2-A_ LC3

<400>  19

Ala Phe Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Asp Asn Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gln Ala Phe Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Tyr Ser Gly Ile Ser Thr 
                85                  90                  95      


Thr Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  20
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ROR2-A_ LC4

<400>  20

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Asp Asn Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gln Ala Phe Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Tyr Ser Gly Ile Ser Thr 
                85                  90                  95      


Thr Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  21
<211>  186
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SITE
<222>  (1)..(186)
<223>  human CD3? (epsilon)

<400>  21

Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro 
            20                  25                  30          


Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp 
        35                  40                  45              


Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys 
    50                  55                  60                  


Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg 
65                  70                  75                  80  


Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg 
                85                  90                  95      


Val Cys Glu Asn Cys Met Glu Met Asp Val Met Ser Val Ala Thr Ile 
            100                 105                 110         


Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu Leu Leu Leu Val Tyr 
        115                 120                 125             


Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys Pro Val Thr Arg Gly 
    130                 135                 140                 


Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro 
145                 150                 155                 160 


Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp 
                165                 170                 175     


Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
            180                 185     


<210>  22
<211>  125
<212>  PRT
<213>  Mus musculus


<220>
<221>  SITE
<222>  (1)..(125)
<223>  CD3-SP34_VH WT

<400>  22

Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120                 125 


<210>  23
<211>  8
<212>  PRT
<213>  Mus musculus


<220>
<221>  SITE
<222>  (1)..(8)
<223>  CD3-SP34_VH-CDR1

<400>  23

Gly Phe Thr Phe Asn Thr Tyr Ala 
1               5               


<210>  24
<211>  10
<212>  PRT
<213>  Mus musculus


<220>
<221>  SITE
<222>  (1)..(10)
<223>  CD3-SP34_VH-CDR2

<400>  24

Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
1               5                   10  


<210>  25
<211>  16
<212>  PRT
<213>  Mus musculus


<220>
<221>  SITE
<222>  (1)..(16)
<223>  CD3-SP34_VH-CDR3

<400>  25

Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr 
1               5                   10                  15      


<210>  26
<211>  109
<212>  PRT
<213>  Mus musculus


<220>
<221>  SITE
<222>  (1)..(109)
<223>  CD3-SP34_VL WT

<400>  26

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  27
<211>  9
<212>  PRT
<213>  Mus musculus


<220>
<221>  SITE
<222>  (1)..(9)
<223>  CD3-SP34_VL-CDR1

<400>  27

Thr Gly Ala Val Thr Thr Ser Asn Tyr 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Mus musculus


<220>
<221>  SITE
<222>  (1)..(9)
<223>  CD3-SP34_VL-CDR3

<400>  28

Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210>  29
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: huCD3-H1L1_VH

<400>  29

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  30
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: huCD3-H1L1_VL

<400>  30

Gln Ala Val Val Thr Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  31
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: huCD3-H1L1-H101G_VH CDR3

<400>  31

Val Arg Gly Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr 
1               5                   10                  15      


<210>  32
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: huCD3-H1L1-H101G_VH

<400>  32

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg Gly Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  33
<211>  330
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SITE
<222>  (1)..(330)
<223>  Human IgG1-Fc

<400>  33

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  34
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Human IgG1-Fc-FEAR

<400>  34

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Ala Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  35
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Human IgG1-Fc-FEAL

<400>  35

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Ala Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Leu 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  36
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SITE
<222>  (1)..(107)
<223>  Human kappa LC

<400>  36

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  37
<211>  106
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SITE
<222>  (1)..(106)
<223>  Human lambda LC

<400>  37

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  38
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: IgG1-F405L

<400>  38

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Leu 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  39
<211>  942
<212>  PRT
<213>  Macaca fascicularis


<220>
<221>  SITE
<222>  (1)..(942)
<223>  cynomolgus monkey (Macaca fascicularis) ROR2

<400>  39

Met Ala Arg Gly Ser Ala Leu Pro Arg Arg Pro Leu Leu Cys Ile Pro 
1               5                   10                  15      


Ala Val Trp Ala Ala Ala Ala Leu Leu Leu Ser Val Ser Arg Thr Ser 
            20                  25                  30          


Gly Glu Val Glu Val Pro Asp Pro Asn Asp Pro Leu Gly Pro Leu Asp 
        35                  40                  45              


Gly Gln Asp Gly Pro Ile Pro Thr Leu Lys Gly Tyr Phe Leu Asn Phe 
    50                  55                  60                  


Leu Glu Pro Val Asn Asn Ile Thr Ile Val Gln Gly Gln Thr Ala Ile 
65                  70                  75                  80  


Leu His Cys Lys Val Ala Gly Asn Pro Pro Pro Asn Val Arg Trp Leu 
                85                  90                  95      


Lys Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Ile Ile Ile Arg 
            100                 105                 110         


Lys Thr Glu Tyr Gly Ser Arg Leu Arg Ile Gln Asp Leu Asp Thr Thr 
        115                 120                 125             


Asp Thr Gly Tyr Tyr Gln Cys Val Ala Thr Asn Gly Met Lys Thr Ile 
    130                 135                 140                 


Thr Ala Thr Gly Val Leu Phe Val Arg Leu Gly Pro Thr His Ser Pro 
145                 150                 155                 160 


Asn His Asn Phe Gln Asp Asp Tyr His Glu Asp Gly Phe Cys Gln Pro 
                165                 170                 175     


Tyr Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Ile Tyr 
            180                 185                 190         


Val Asp Ser Leu Gln Met Gln Gly Glu Ile Glu Asn Arg Ile Thr Ala 
        195                 200                 205             


Ala Phe Thr Met Ile Gly Thr Ser Thr His Leu Ser Asp Gln Cys Ser 
    210                 215                 220                 


Gln Phe Ala Ile Pro Ser Phe Cys His Phe Val Phe Pro Leu Cys Asp 
225                 230                 235                 240 


Ala Arg Ser Arg Ala Pro Lys Pro Arg Glu Leu Cys Arg Asp Glu Cys 
                245                 250                 255     


Glu Val Leu Glu Ser Asp Leu Cys Arg Gln Glu Tyr Thr Ile Ala Arg 
            260                 265                 270         


Ser Asn Pro Leu Ile Leu Met Arg Leu Gln Leu Pro Lys Cys Glu Ala 
        275                 280                 285             


Leu Pro Met Pro Glu Ser Pro Asp Ala Ala Asn Cys Met Arg Ile Gly 
    290                 295                 300                 


Ile Pro Ala Glu Arg Leu Gly Arg Tyr His Gln Cys Tyr Asn Gly Ser 
305                 310                 315                 320 


Gly Thr Asp Tyr Arg Gly Thr Ala Ser Thr Thr Lys Ser Gly His Gln 
                325                 330                 335     


Cys Gln Pro Trp Ala Leu Gln His Pro His Ser His His Leu Ser Ser 
            340                 345                 350         


Thr Asp Phe Pro Glu Leu Gly Gly Gly His Ala Tyr Cys Arg Asn Pro 
        355                 360                 365             


Gly Gly Gln Met Glu Gly Pro Trp Cys Phe Thr Gln Asn Lys Asn Val 
    370                 375                 380                 


Arg Met Glu Leu Cys Asp Val Pro Ser Cys Ser Pro Arg Asp Ser Ser 
385                 390                 395                 400 


Lys Met Gly Ile Leu Tyr Ile Leu Val Pro Ser Ile Ala Ile Pro Leu 
                405                 410                 415     


Val Ile Ala Cys Leu Phe Phe Leu Val Cys Met Cys Arg Asn Lys Gln 
            420                 425                 430         


Lys Ala Ser Ala Ser Thr Pro Gln Arg Arg Gln Leu Met Ala Ser Pro 
        435                 440                 445             


Ser Gln Asp Met Glu Met Pro Leu Ile Asn Gln His Lys Gln Ala Lys 
    450                 455                 460                 


Leu Lys Glu Ile Ser Leu Ser Ala Val Arg Phe Met Glu Glu Leu Gly 
465                 470                 475                 480 


Glu Asp Arg Phe Gly Lys Val Tyr Lys Gly His Leu Phe Gly Pro Ala 
                485                 490                 495     


Pro Gly Glu Gln Thr Gln Ala Val Ala Ile Lys Thr Leu Lys Asp Lys 
            500                 505                 510         


Ala Glu Gly Pro Leu Arg Glu Glu Phe Arg His Glu Ala Met Leu Arg 
        515                 520                 525             


Ala Arg Leu Gln His Pro Asn Ile Val Cys Leu Leu Gly Val Val Thr 
    530                 535                 540                 


Lys Asp Gln Pro Leu Ser Met Ile Phe Ser Tyr Cys Ser His Ser Asp 
545                 550                 555                 560 


Leu His Glu Phe Leu Val Met Arg Ser Pro His Ser Asp Val Gly Ser 
                565                 570                 575     


Thr Asp Asp Asp Arg Thr Val Lys Ser Ala Leu Glu Pro Pro Asp Phe 
            580                 585                 590         


Val His Leu Val Ala Gln Ile Ala Ala Gly Met Glu Tyr Leu Ser Ser 
        595                 600                 605             


His His Val Val His Lys Asp Leu Ala Thr Arg Asn Val Leu Val Tyr 
    610                 615                 620                 


Asp Lys Leu Asn Val Lys Ile Ser Asp Leu Gly Leu Phe Arg Glu Val 
625                 630                 635                 640 


Tyr Ala Ala Asp Tyr Tyr Lys Leu Leu Gly Asn Ser Leu Leu Pro Ile 
                645                 650                 655     


Arg Trp Met Ala Pro Glu Ala Ile Met Tyr Gly Lys Phe Ser Ile Asp 
            660                 665                 670         


Ser Asp Ile Trp Ser Tyr Gly Val Val Leu Trp Glu Val Phe Ser Tyr 
        675                 680                 685             


Gly Leu Gln Pro Tyr Cys Gly Tyr Ser Asn Gln Asp Val Val Glu Met 
    690                 695                 700                 


Ile Arg Asn Arg Gln Val Leu Pro Cys Pro Asp Asp Cys Pro Ala Trp 
705                 710                 715                 720 


Val Tyr Ala Leu Met Ile Glu Cys Trp Asn Glu Phe Pro Ser Arg Arg 
                725                 730                 735     


Pro Arg Phe Lys Asp Ile His Ser Arg Leu Arg Ala Trp Gly Asn Leu 
            740                 745                 750         


Ser Asn Tyr Asn Ser Ser Ala Gln Thr Ser Gly Ala Ser Asn Thr Thr 
        755                 760                 765             


Gln Thr Ser Ser Leu Ser Thr Ser Pro Val Ser Asn Val Ser Asn Ala 
    770                 775                 780                 


Arg Tyr Met Gly Pro Lys Gln Lys Ala Pro Pro Phe Pro Gln Pro Gln 
785                 790                 795                 800 


Phe Ile Pro Met Lys Gly Gln Ile Arg Pro Met Val Pro Pro Pro Gln 
                805                 810                 815     


Leu Tyr Ile Pro Val Asn Gly Tyr Gln Pro Val Pro Ala Tyr Gly Ala 
            820                 825                 830         


Tyr Leu Pro Asn Phe Tyr Pro Val Gln Ile Pro Met Gln Met Ala Pro 
        835                 840                 845             


Gln Gln Val Pro Pro Gln Met Val Pro Lys Pro Ser Ser His His Ser 
    850                 855                 860                 


Gly Ser Gly Ser Thr Ser Thr Gly Tyr Val Thr Thr Ala Pro Ser Asn 
865                 870                 875                 880 


Thr Ser Val Ala Asp Arg Ala Ala Leu Leu Ser Glu Gly Thr Glu Asp 
                885                 890                 895     


Ala Gln Asn Ala Pro Glu Asp Gly Ala Gln Ser Pro Val Gln Glu Ala 
            900                 905                 910         


Glu Glu Glu Glu Gly Ser Val Pro Glu Thr Glu Leu Leu Gly Asp Ser 
        915                 920                 925             


Asp Thr Leu Gln Val Asp Glu Ala Gln Val Gln Leu Glu Ala 
    930                 935                 940         


<210>  40
<211>  937
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SITE
<222>  (1)..(937)
<223>  Human ROR1

<400>  40

Met His Arg Pro Arg Arg Arg Gly Thr Arg Pro Pro Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Ala Leu Leu Leu Ala Ala Arg Gly Ala Ala Ala Gln Glu Thr 
            20                  25                  30          


Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser Trp Asn Ile 
        35                  40                  45              


Ser Ser Glu Leu Asn Lys Asp Ser Tyr Leu Thr Leu Asp Glu Pro Met 
    50                  55                  60                  


Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu His Cys Lys 
65                  70                  75                  80  


Val Ser Gly Asn Pro Pro Pro Thr Ile Arg Trp Phe Lys Asn Asp Ala 
                85                  90                  95      


Pro Val Val Gln Glu Pro Arg Arg Leu Ser Phe Arg Ser Thr Ile Tyr 
            100                 105                 110         


Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp Thr Gly Tyr 
        115                 120                 125             


Phe Gln Cys Val Ala Thr Asn Gly Lys Glu Val Val Ser Ser Thr Gly 
    130                 135                 140                 


Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser Pro Gly Tyr 
145                 150                 155                 160 


Ser Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr Arg Gly Ile 
                165                 170                 175     


Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met Glu Ser Leu 
            180                 185                 190         


His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala Phe Thr Met 
        195                 200                 205             


Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln Phe Ala Ile 
    210                 215                 220                 


Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu Thr Ser Ser 
225                 230                 235                 240 


Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu Ile Leu Glu 
                245                 250                 255     


Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser Asn Pro Met 
            260                 265                 270         


Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu Pro Gln Pro 
        275                 280                 285             


Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile Pro Met Ala 
    290                 295                 300                 


Asp Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr Gly Val Asp 
305                 310                 315                 320 


Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln Cys Gln Pro 
                325                 330                 335     


Trp Asn Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala Leu Arg Phe 
            340                 345                 350         


Pro Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro Gly Asn Gln 
        355                 360                 365             


Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe Lys Ser Asp 
    370                 375                 380                 


Leu Cys Asp Ile Pro Ala Cys Asp Ser Lys Asp Ser Lys Glu Lys Asn 
385                 390                 395                 400 


Lys Met Glu Ile Leu Tyr Ile Leu Val Pro Ser Val Ala Ile Pro Leu 
                405                 410                 415     


Ala Ile Ala Leu Leu Phe Phe Phe Ile Cys Val Cys Arg Asn Asn Gln 
            420                 425                 430         


Lys Ser Ser Ser Ala Pro Val Gln Arg Gln Pro Lys His Val Arg Gly 
        435                 440                 445             


Gln Asn Val Glu Met Ser Met Leu Asn Ala Tyr Lys Pro Lys Ser Lys 
    450                 455                 460                 


Ala Lys Glu Leu Pro Leu Ser Ala Val Arg Phe Met Glu Glu Leu Gly 
465                 470                 475                 480 


Glu Cys Ala Phe Gly Lys Ile Tyr Lys Gly His Leu Tyr Leu Pro Gly 
                485                 490                 495     


Met Asp His Ala Gln Leu Val Ala Ile Lys Thr Leu Lys Asp Tyr Asn 
            500                 505                 510         


Asn Pro Gln Gln Trp Thr Glu Phe Gln Gln Glu Ala Ser Leu Met Ala 
        515                 520                 525             


Glu Leu His His Pro Asn Ile Val Cys Leu Leu Gly Ala Val Thr Gln 
    530                 535                 540                 


Glu Gln Pro Val Cys Met Leu Phe Glu Tyr Ile Asn Gln Gly Asp Leu 
545                 550                 555                 560 


His Glu Phe Leu Ile Met Arg Ser Pro His Ser Asp Val Gly Cys Ser 
                565                 570                 575     


Ser Asp Glu Asp Gly Thr Val Lys Ser Ser Leu Asp His Gly Asp Phe 
            580                 585                 590         


Leu His Ile Ala Ile Gln Ile Ala Ala Gly Met Glu Tyr Leu Ser Ser 
        595                 600                 605             


His Phe Phe Val His Lys Asp Leu Ala Ala Arg Asn Ile Leu Ile Gly 
    610                 615                 620                 


Glu Gln Leu His Val Lys Ile Ser Asp Leu Gly Leu Ser Arg Glu Ile 
625                 630                 635                 640 


Tyr Ser Ala Asp Tyr Tyr Arg Val Gln Ser Lys Ser Leu Leu Pro Ile 
                645                 650                 655     


Arg Trp Met Pro Pro Glu Ala Ile Met Tyr Gly Lys Phe Ser Ser Asp 
            660                 665                 670         


Ser Asp Ile Trp Ser Phe Gly Val Val Leu Trp Glu Ile Phe Ser Phe 
        675                 680                 685             


Gly Leu Gln Pro Tyr Tyr Gly Phe Ser Asn Gln Glu Val Ile Glu Met 
    690                 695                 700                 


Val Arg Lys Arg Gln Leu Leu Pro Cys Ser Glu Asp Cys Pro Pro Arg 
705                 710                 715                 720 


Met Tyr Ser Leu Met Thr Glu Cys Trp Asn Glu Ile Pro Ser Arg Arg 
                725                 730                 735     


Pro Arg Phe Lys Asp Ile His Val Arg Leu Arg Ser Trp Glu Gly Leu 
            740                 745                 750         


Ser Ser His Thr Ser Ser Thr Thr Pro Ser Gly Gly Asn Ala Thr Thr 
        755                 760                 765             


Gln Thr Thr Ser Leu Ser Ala Ser Pro Val Ser Asn Leu Ser Asn Pro 
    770                 775                 780                 


Arg Tyr Pro Asn Tyr Met Phe Pro Ser Gln Gly Ile Thr Pro Gln Gly 
785                 790                 795                 800 


Gln Ile Ala Gly Phe Ile Gly Pro Pro Ile Pro Gln Asn Gln Arg Phe 
                805                 810                 815     


Ile Pro Ile Asn Gly Tyr Pro Ile Pro Pro Gly Tyr Ala Ala Phe Pro 
            820                 825                 830         


Ala Ala His Tyr Gln Pro Thr Gly Pro Pro Arg Val Ile Gln His Cys 
        835                 840                 845             


Pro Pro Pro Lys Ser Arg Ser Pro Ser Ser Ala Ser Gly Ser Thr Ser 
    850                 855                 860                 


Thr Gly His Val Thr Ser Leu Pro Ser Ser Gly Ser Asn Gln Glu Ala 
865                 870                 875                 880 


Asn Ile Pro Leu Leu Pro His Met Ser Ile Pro Asn His Pro Gly Gly 
                885                 890                 895     


Met Gly Ile Thr Val Phe Gly Asn Lys Ser Gln Lys Pro Tyr Lys Ile 
            900                 905                 910         


Asp Ser Lys Gln Ala Ser Leu Leu Gly Asp Ala Asn Ile His Gly His 
        915                 920                 925             


Thr Glu Ser Met Ile Ser Ala Glu Leu 
    930                 935         


<210>  41
<211>  942
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SITE
<222>  (1)..(942)
<223>  ROR2mf-T322M

<400>  41

Met Ala Arg Gly Ser Ala Leu Pro Arg Arg Pro Leu Leu Cys Ile Pro 
1               5                   10                  15      


Ala Val Trp Ala Ala Ala Ala Leu Leu Leu Ser Val Ser Arg Thr Ser 
            20                  25                  30          


Gly Glu Val Glu Val Pro Asp Pro Asn Asp Pro Leu Gly Pro Leu Asp 
        35                  40                  45              


Gly Gln Asp Gly Pro Ile Pro Thr Leu Lys Gly Tyr Phe Leu Asn Phe 
    50                  55                  60                  


Leu Glu Pro Val Asn Asn Ile Thr Ile Val Gln Gly Gln Thr Ala Ile 
65                  70                  75                  80  


Leu His Cys Lys Val Ala Gly Asn Pro Pro Pro Asn Val Arg Trp Leu 
                85                  90                  95      


Lys Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Ile Ile Ile Arg 
            100                 105                 110         


Lys Thr Glu Tyr Gly Ser Arg Leu Arg Ile Gln Asp Leu Asp Thr Thr 
        115                 120                 125             


Asp Thr Gly Tyr Tyr Gln Cys Val Ala Thr Asn Gly Met Lys Thr Ile 
    130                 135                 140                 


Thr Ala Thr Gly Val Leu Phe Val Arg Leu Gly Pro Thr His Ser Pro 
145                 150                 155                 160 


Asn His Asn Phe Gln Asp Asp Tyr His Glu Asp Gly Phe Cys Gln Pro 
                165                 170                 175     


Tyr Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Ile Tyr 
            180                 185                 190         


Val Asp Ser Leu Gln Met Gln Gly Glu Ile Glu Asn Arg Ile Thr Ala 
        195                 200                 205             


Ala Phe Thr Met Ile Gly Thr Ser Thr His Leu Ser Asp Gln Cys Ser 
    210                 215                 220                 


Gln Phe Ala Ile Pro Ser Phe Cys His Phe Val Phe Pro Leu Cys Asp 
225                 230                 235                 240 


Ala Arg Ser Arg Ala Pro Lys Pro Arg Glu Leu Cys Arg Asp Glu Cys 
                245                 250                 255     


Glu Val Leu Glu Ser Asp Leu Cys Arg Gln Glu Tyr Thr Ile Ala Arg 
            260                 265                 270         


Ser Asn Pro Leu Ile Leu Met Arg Leu Gln Leu Pro Lys Cys Glu Ala 
        275                 280                 285             


Leu Pro Met Pro Glu Ser Pro Asp Ala Ala Asn Cys Met Arg Ile Gly 
    290                 295                 300                 


Ile Pro Ala Glu Arg Leu Gly Arg Tyr His Gln Cys Tyr Asn Gly Ser 
305                 310                 315                 320 


Gly Met Asp Tyr Arg Gly Thr Ala Ser Thr Thr Lys Ser Gly His Gln 
                325                 330                 335     


Cys Gln Pro Trp Ala Leu Gln His Pro His Ser His His Leu Ser Ser 
            340                 345                 350         


Thr Asp Phe Pro Glu Leu Gly Gly Gly His Ala Tyr Cys Arg Asn Pro 
        355                 360                 365             


Gly Gly Gln Met Glu Gly Pro Trp Cys Phe Thr Gln Asn Lys Asn Val 
    370                 375                 380                 


Arg Met Glu Leu Cys Asp Val Pro Ser Cys Ser Pro Arg Asp Ser Ser 
385                 390                 395                 400 


Lys Met Gly Ile Leu Tyr Ile Leu Val Pro Ser Ile Ala Ile Pro Leu 
                405                 410                 415     


Val Ile Ala Cys Leu Phe Phe Leu Val Cys Met Cys Arg Asn Lys Gln 
            420                 425                 430         


Lys Ala Ser Ala Ser Thr Pro Gln Arg Arg Gln Leu Met Ala Ser Pro 
        435                 440                 445             


Ser Gln Asp Met Glu Met Pro Leu Ile Asn Gln His Lys Gln Ala Lys 
    450                 455                 460                 


Leu Lys Glu Ile Ser Leu Ser Ala Val Arg Phe Met Glu Glu Leu Gly 
465                 470                 475                 480 


Glu Asp Arg Phe Gly Lys Val Tyr Lys Gly His Leu Phe Gly Pro Ala 
                485                 490                 495     


Pro Gly Glu Gln Thr Gln Ala Val Ala Ile Lys Thr Leu Lys Asp Lys 
            500                 505                 510         


Ala Glu Gly Pro Leu Arg Glu Glu Phe Arg His Glu Ala Met Leu Arg 
        515                 520                 525             


Ala Arg Leu Gln His Pro Asn Ile Val Cys Leu Leu Gly Val Val Thr 
    530                 535                 540                 


Lys Asp Gln Pro Leu Ser Met Ile Phe Ser Tyr Cys Ser His Ser Asp 
545                 550                 555                 560 


Leu His Glu Phe Leu Val Met Arg Ser Pro His Ser Asp Val Gly Ser 
                565                 570                 575     


Thr Asp Asp Asp Arg Thr Val Lys Ser Ala Leu Glu Pro Pro Asp Phe 
            580                 585                 590         


Val His Leu Val Ala Gln Ile Ala Ala Gly Met Glu Tyr Leu Ser Ser 
        595                 600                 605             


His His Val Val His Lys Asp Leu Ala Thr Arg Asn Val Leu Val Tyr 
    610                 615                 620                 


Asp Lys Leu Asn Val Lys Ile Ser Asp Leu Gly Leu Phe Arg Glu Val 
625                 630                 635                 640 


Tyr Ala Ala Asp Tyr Tyr Lys Leu Leu Gly Asn Ser Leu Leu Pro Ile 
                645                 650                 655     


Arg Trp Met Ala Pro Glu Ala Ile Met Tyr Gly Lys Phe Ser Ile Asp 
            660                 665                 670         


Ser Asp Ile Trp Ser Tyr Gly Val Val Leu Trp Glu Val Phe Ser Tyr 
        675                 680                 685             


Gly Leu Gln Pro Tyr Cys Gly Tyr Ser Asn Gln Asp Val Val Glu Met 
    690                 695                 700                 


Ile Arg Asn Arg Gln Val Leu Pro Cys Pro Asp Asp Cys Pro Ala Trp 
705                 710                 715                 720 


Val Tyr Ala Leu Met Ile Glu Cys Trp Asn Glu Phe Pro Ser Arg Arg 
                725                 730                 735     


Pro Arg Phe Lys Asp Ile His Ser Arg Leu Arg Ala Trp Gly Asn Leu 
            740                 745                 750         


Ser Asn Tyr Asn Ser Ser Ala Gln Thr Ser Gly Ala Ser Asn Thr Thr 
        755                 760                 765             


Gln Thr Ser Ser Leu Ser Thr Ser Pro Val Ser Asn Val Ser Asn Ala 
    770                 775                 780                 


Arg Tyr Met Gly Pro Lys Gln Lys Ala Pro Pro Phe Pro Gln Pro Gln 
785                 790                 795                 800 


Phe Ile Pro Met Lys Gly Gln Ile Arg Pro Met Val Pro Pro Pro Gln 
                805                 810                 815     


Leu Tyr Ile Pro Val Asn Gly Tyr Gln Pro Val Pro Ala Tyr Gly Ala 
            820                 825                 830         


Tyr Leu Pro Asn Phe Tyr Pro Val Gln Ile Pro Met Gln Met Ala Pro 
        835                 840                 845             


Gln Gln Val Pro Pro Gln Met Val Pro Lys Pro Ser Ser His His Ser 
    850                 855                 860                 


Gly Ser Gly Ser Thr Ser Thr Gly Tyr Val Thr Thr Ala Pro Ser Asn 
865                 870                 875                 880 


Thr Ser Val Ala Asp Arg Ala Ala Leu Leu Ser Glu Gly Thr Glu Asp 
                885                 890                 895     


Ala Gln Asn Ala Pro Glu Asp Gly Ala Gln Ser Pro Val Gln Glu Ala 
            900                 905                 910         


Glu Glu Glu Glu Gly Ser Val Pro Glu Thr Glu Leu Leu Gly Asp Ser 
        915                 920                 925             


Asp Thr Leu Gln Val Asp Glu Ala Gln Val Gln Leu Glu Ala 
    930                 935                 940         


<210>  42
<211>  929
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ROR112

<400>  42

Met His Arg Pro Arg Arg Arg Gly Thr Arg Pro Pro Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Ala Leu Leu Leu Ala Ala Arg Gly Ala Ala Ala Gln Glu Thr 
            20                  25                  30          


Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser Trp Asn Ile 
        35                  40                  45              


Ser Ser Glu Leu Asn Lys Asp Ser Tyr Leu Thr Leu Asp Glu Pro Met 
    50                  55                  60                  


Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu His Cys Lys 
65                  70                  75                  80  


Val Ser Gly Asn Pro Pro Pro Thr Ile Arg Trp Phe Lys Asn Asp Ala 
                85                  90                  95      


Pro Val Val Gln Glu Pro Arg Arg Leu Ser Phe Arg Ser Thr Ile Tyr 
            100                 105                 110         


Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp Thr Gly Tyr 
        115                 120                 125             


Phe Gln Cys Val Ala Thr Asn Gly Lys Glu Val Val Ser Ser Thr Gly 
    130                 135                 140                 


Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser Pro Gly Tyr 
145                 150                 155                 160 


Ser Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr Arg Gly Ile 
                165                 170                 175     


Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met Glu Ser Leu 
            180                 185                 190         


His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala Phe Thr Met 
        195                 200                 205             


Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln Phe Ala Ile 
    210                 215                 220                 


Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu Thr Ser Ser 
225                 230                 235                 240 


Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu Ile Leu Glu 
                245                 250                 255     


Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser Asn Pro Met 
            260                 265                 270         


Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu Pro Gln Pro 
        275                 280                 285             


Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile Pro Met Ala 
    290                 295                 300                 


Asp Pro Ile Asn Lys Asn Cys Tyr Asn Gly Ser Gly Met Asp Tyr Arg 
305                 310                 315                 320 


Gly Thr Ala Ser Thr Thr Lys Ser Gly His Gln Cys Gln Pro Trp Ala 
                325                 330                 335     


Leu Gln His Pro His Ser His His Leu Ser Ser Thr Asp Phe Pro Glu 
            340                 345                 350         


Leu Gly Gly Gly His Ala Tyr Cys Arg Asn Pro Gly Gly Gln Met Glu 
        355                 360                 365             


Gly Pro Trp Cys Phe Thr Gln Asn Lys Asn Val Arg Met Glu Leu Cys 
    370                 375                 380                 


Asp Val Pro Ser Cys Ser Pro Arg Asp Ser Ser Lys Met Gly Ile Leu 
385                 390                 395                 400 


Val Pro Ser Val Ala Ile Pro Leu Ala Ile Ala Leu Leu Phe Phe Phe 
                405                 410                 415     


Ile Cys Val Cys Arg Asn Asn Gln Lys Ser Ser Ser Ala Pro Val Gln 
            420                 425                 430         


Arg Gln Pro Lys His Val Arg Gly Gln Asn Val Glu Met Ser Met Leu 
        435                 440                 445             


Asn Ala Tyr Lys Pro Lys Ser Lys Ala Lys Glu Leu Pro Leu Ser Ala 
    450                 455                 460                 


Val Arg Phe Met Glu Glu Leu Gly Glu Cys Ala Phe Gly Lys Ile Tyr 
465                 470                 475                 480 


Lys Gly His Leu Tyr Leu Pro Gly Met Asp His Ala Gln Leu Val Ala 
                485                 490                 495     


Ile Lys Thr Leu Lys Asp Tyr Asn Asn Pro Gln Gln Trp Thr Glu Phe 
            500                 505                 510         


Gln Gln Glu Ala Ser Leu Met Ala Glu Leu His His Pro Asn Ile Val 
        515                 520                 525             


Cys Leu Leu Gly Ala Val Thr Gln Glu Gln Pro Val Cys Met Leu Phe 
    530                 535                 540                 


Glu Tyr Ile Asn Gln Gly Asp Leu His Glu Phe Leu Ile Met Arg Ser 
545                 550                 555                 560 


Pro His Ser Asp Val Gly Cys Ser Ser Asp Glu Asp Gly Thr Val Lys 
                565                 570                 575     


Ser Ser Leu Asp His Gly Asp Phe Leu His Ile Ala Ile Gln Ile Ala 
            580                 585                 590         


Ala Gly Met Glu Tyr Leu Ser Ser His Phe Phe Val His Lys Asp Leu 
        595                 600                 605             


Ala Ala Arg Asn Ile Leu Ile Gly Glu Gln Leu His Val Lys Ile Ser 
    610                 615                 620                 


Asp Leu Gly Leu Ser Arg Glu Ile Tyr Ser Ala Asp Tyr Tyr Arg Val 
625                 630                 635                 640 


Gln Ser Lys Ser Leu Leu Pro Ile Arg Trp Met Pro Pro Glu Ala Ile 
                645                 650                 655     


Met Tyr Gly Lys Phe Ser Ser Asp Ser Asp Ile Trp Ser Phe Gly Val 
            660                 665                 670         


Val Leu Trp Glu Ile Phe Ser Phe Gly Leu Gln Pro Tyr Tyr Gly Phe 
        675                 680                 685             


Ser Asn Gln Glu Val Ile Glu Met Val Arg Lys Arg Gln Leu Leu Pro 
    690                 695                 700                 


Cys Ser Glu Asp Cys Pro Pro Arg Met Tyr Ser Leu Met Thr Glu Cys 
705                 710                 715                 720 


Trp Asn Glu Ile Pro Ser Arg Arg Pro Arg Phe Lys Asp Ile His Val 
                725                 730                 735     


Arg Leu Arg Ser Trp Glu Gly Leu Ser Ser His Thr Ser Ser Thr Thr 
            740                 745                 750         


Pro Ser Gly Gly Asn Ala Thr Thr Gln Thr Thr Ser Leu Ser Ala Ser 
        755                 760                 765             


Pro Val Ser Asn Leu Ser Asn Pro Arg Tyr Pro Asn Tyr Met Phe Pro 
    770                 775                 780                 


Ser Gln Gly Ile Thr Pro Gln Gly Gln Ile Ala Gly Phe Ile Gly Pro 
785                 790                 795                 800 


Pro Ile Pro Gln Asn Gln Arg Phe Ile Pro Ile Asn Gly Tyr Pro Ile 
                805                 810                 815     


Pro Pro Gly Tyr Ala Ala Phe Pro Ala Ala His Tyr Gln Pro Thr Gly 
            820                 825                 830         


Pro Pro Arg Val Ile Gln His Cys Pro Pro Pro Lys Ser Arg Ser Pro 
        835                 840                 845             


Ser Ser Ala Ser Gly Ser Thr Ser Thr Gly His Val Thr Ser Leu Pro 
    850                 855                 860                 


Ser Ser Gly Ser Asn Gln Glu Ala Asn Ile Pro Leu Leu Pro His Met 
865                 870                 875                 880 


Ser Ile Pro Asn His Pro Gly Gly Met Gly Ile Thr Val Phe Gly Asn 
                885                 890                 895     


Lys Ser Gln Lys Pro Tyr Lys Ile Asp Ser Lys Gln Ala Ser Leu Leu 
            900                 905                 910         


Gly Asp Ala Asn Ile His Gly His Thr Glu Ser Met Ile Ser Ala Glu 
        915                 920                 925             


Leu 
    


<210>  43
<211>  936
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ROR121

<400>  43

Met His Arg Pro Arg Arg Arg Gly Thr Arg Pro Pro Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Ala Leu Leu Leu Ala Ala Arg Gly Ala Ala Ala Gln Glu Thr 
            20                  25                  30          


Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser Trp Asn Ile 
        35                  40                  45              


Ser Ser Glu Leu Asn Lys Asp Ser Tyr Leu Thr Leu Asp Glu Pro Met 
    50                  55                  60                  


Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu His Cys Lys 
65                  70                  75                  80  


Val Ser Gly Asn Pro Pro Pro Thr Ile Arg Trp Phe Lys Asn Asp Ala 
                85                  90                  95      


Pro Val Val Gln Glu Pro Arg Arg Leu Ser Phe Arg Ser Thr Ile Tyr 
            100                 105                 110         


Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp Thr Gly Tyr 
        115                 120                 125             


Phe Gln Cys Val Ala Thr Asn Gly Lys Glu Val Val Ser Ser Thr Gly 
    130                 135                 140                 


Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser Pro Gly Tyr 
145                 150                 155                 160 


Ser Asp Glu Tyr His Glu Asp Gly Phe Cys Gln Pro Tyr Arg Gly Ile 
                165                 170                 175     


Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Ile Tyr Val Asp Ser Leu 
            180                 185                 190         


Gln Met Gln Gly Glu Ile Glu Asn Arg Ile Thr Ala Ala Phe Thr Met 
        195                 200                 205             


Ile Gly Thr Ser Thr His Leu Ser Asp Gln Cys Ser Gln Phe Ala Ile 
    210                 215                 220                 


Pro Ser Phe Cys His Phe Val Phe Pro Leu Cys Asp Ala Arg Ser Arg 
225                 230                 235                 240 


Thr Pro Lys Pro Arg Glu Leu Cys Arg Asp Glu Cys Glu Val Leu Glu 
                245                 250                 255     


Ser Asp Leu Cys Arg Gln Glu Tyr Thr Ile Ala Arg Ser Asn Pro Leu 
            260                 265                 270         


Ile Leu Met Arg Leu Gln Leu Pro Lys Cys Glu Ala Leu Pro Met Pro 
        275                 280                 285             


Glu Ser Pro Asp Ala Ala Asn Cys Met Arg Ile Ile Pro Met Ala Asp 
    290                 295                 300                 


Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr Gly Val Asp Tyr 
305                 310                 315                 320 


Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln Cys Gln Pro Trp 
                325                 330                 335     


Asn Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala Leu Arg Phe Pro 
            340                 345                 350         


Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro Gly Asn Gln Lys 
        355                 360                 365             


Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe Lys Ser Asp Leu 
    370                 375                 380                 


Cys Asp Ile Pro Ala Cys Asp Ser Lys Asp Ser Lys Glu Lys Asn Lys 
385                 390                 395                 400 


Met Glu Ile Leu Tyr Ile Leu Val Pro Ser Val Ala Ile Pro Leu Ala 
                405                 410                 415     


Ile Ala Leu Leu Phe Phe Phe Ile Cys Val Cys Arg Asn Asn Gln Lys 
            420                 425                 430         


Ser Ser Ser Ala Pro Val Gln Arg Gln Pro Lys His Val Arg Gly Gln 
        435                 440                 445             


Asn Val Glu Met Ser Met Leu Asn Ala Tyr Lys Pro Lys Ser Lys Ala 
    450                 455                 460                 


Lys Glu Leu Pro Leu Ser Ala Val Arg Phe Met Glu Glu Leu Gly Glu 
465                 470                 475                 480 


Cys Ala Phe Gly Lys Ile Tyr Lys Gly His Leu Tyr Leu Pro Gly Met 
                485                 490                 495     


Asp His Ala Gln Leu Val Ala Ile Lys Thr Leu Lys Asp Tyr Asn Asn 
            500                 505                 510         


Pro Gln Gln Trp Thr Glu Phe Gln Gln Glu Ala Ser Leu Met Ala Glu 
        515                 520                 525             


Leu His His Pro Asn Ile Val Cys Leu Leu Gly Ala Val Thr Gln Glu 
    530                 535                 540                 


Gln Pro Val Cys Met Leu Phe Glu Tyr Ile Asn Gln Gly Asp Leu His 
545                 550                 555                 560 


Glu Phe Leu Ile Met Arg Ser Pro His Ser Asp Val Gly Cys Ser Ser 
                565                 570                 575     


Asp Glu Asp Gly Thr Val Lys Ser Ser Leu Asp His Gly Asp Phe Leu 
            580                 585                 590         


His Ile Ala Ile Gln Ile Ala Ala Gly Met Glu Tyr Leu Ser Ser His 
        595                 600                 605             


Phe Phe Val His Lys Asp Leu Ala Ala Arg Asn Ile Leu Ile Gly Glu 
    610                 615                 620                 


Gln Leu His Val Lys Ile Ser Asp Leu Gly Leu Ser Arg Glu Ile Tyr 
625                 630                 635                 640 


Ser Ala Asp Tyr Tyr Arg Val Gln Ser Lys Ser Leu Leu Pro Ile Arg 
                645                 650                 655     


Trp Met Pro Pro Glu Ala Ile Met Tyr Gly Lys Phe Ser Ser Asp Ser 
            660                 665                 670         


Asp Ile Trp Ser Phe Gly Val Val Leu Trp Glu Ile Phe Ser Phe Gly 
        675                 680                 685             


Leu Gln Pro Tyr Tyr Gly Phe Ser Asn Gln Glu Val Ile Glu Met Val 
    690                 695                 700                 


Arg Lys Arg Gln Leu Leu Pro Cys Ser Glu Asp Cys Pro Pro Arg Met 
705                 710                 715                 720 


Tyr Ser Leu Met Thr Glu Cys Trp Asn Glu Ile Pro Ser Arg Arg Pro 
                725                 730                 735     


Arg Phe Lys Asp Ile His Val Arg Leu Arg Ser Trp Glu Gly Leu Ser 
            740                 745                 750         


Ser His Thr Ser Ser Thr Thr Pro Ser Gly Gly Asn Ala Thr Thr Gln 
        755                 760                 765             


Thr Thr Ser Leu Ser Ala Ser Pro Val Ser Asn Leu Ser Asn Pro Arg 
    770                 775                 780                 


Tyr Pro Asn Tyr Met Phe Pro Ser Gln Gly Ile Thr Pro Gln Gly Gln 
785                 790                 795                 800 


Ile Ala Gly Phe Ile Gly Pro Pro Ile Pro Gln Asn Gln Arg Phe Ile 
                805                 810                 815     


Pro Ile Asn Gly Tyr Pro Ile Pro Pro Gly Tyr Ala Ala Phe Pro Ala 
            820                 825                 830         


Ala His Tyr Gln Pro Thr Gly Pro Pro Arg Val Ile Gln His Cys Pro 
        835                 840                 845             


Pro Pro Lys Ser Arg Ser Pro Ser Ser Ala Ser Gly Ser Thr Ser Thr 
    850                 855                 860                 


Gly His Val Thr Ser Leu Pro Ser Ser Gly Ser Asn Gln Glu Ala Asn 
865                 870                 875                 880 


Ile Pro Leu Leu Pro His Met Ser Ile Pro Asn His Pro Gly Gly Met 
                885                 890                 895     


Gly Ile Thr Val Phe Gly Asn Lys Ser Gln Lys Pro Tyr Lys Ile Asp 
            900                 905                 910         


Ser Lys Gln Ala Ser Leu Leu Gly Asp Ala Asn Ile His Gly His Thr 
        915                 920                 925             


Glu Ser Met Ile Ser Ala Glu Leu 
    930                 935     


<210>  44
<211>  936
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ROR122

<400>  44

Met His Arg Pro Arg Arg Arg Gly Thr Arg Pro Pro Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Ala Leu Leu Leu Ala Ala Arg Gly Ala Ala Ala Gln Glu Thr 
            20                  25                  30          


Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser Trp Asn Ile 
        35                  40                  45              


Ser Ser Glu Leu Asn Lys Asp Ser Tyr Leu Thr Leu Asp Glu Pro Met 
    50                  55                  60                  


Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu His Cys Lys 
65                  70                  75                  80  


Val Ser Gly Asn Pro Pro Pro Thr Ile Arg Trp Phe Lys Asn Asp Ala 
                85                  90                  95      


Pro Val Val Gln Glu Pro Arg Arg Leu Ser Phe Arg Ser Thr Ile Tyr 
            100                 105                 110         


Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp Thr Gly Tyr 
        115                 120                 125             


Phe Gln Cys Val Ala Thr Asn Gly Lys Glu Val Val Ser Ser Thr Gly 
    130                 135                 140                 


Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser Pro Gly Tyr 
145                 150                 155                 160 


Ser Asp Glu Tyr His Glu Asp Gly Phe Cys Gln Pro Tyr Arg Gly Ile 
                165                 170                 175     


Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Ile Tyr Val Asp Ser Leu 
            180                 185                 190         


Gln Met Gln Gly Glu Ile Glu Asn Arg Ile Thr Ala Ala Phe Thr Met 
        195                 200                 205             


Ile Gly Thr Ser Thr His Leu Ser Asp Gln Cys Ser Gln Phe Ala Ile 
    210                 215                 220                 


Pro Ser Phe Cys His Phe Val Phe Pro Leu Cys Asp Ala Arg Ser Arg 
225                 230                 235                 240 


Thr Pro Lys Pro Arg Glu Leu Cys Arg Asp Glu Cys Glu Val Leu Glu 
                245                 250                 255     


Ser Asp Leu Cys Arg Gln Glu Tyr Thr Ile Ala Arg Ser Asn Pro Leu 
            260                 265                 270         


Ile Leu Met Arg Leu Gln Leu Pro Lys Cys Glu Ala Leu Pro Met Pro 
        275                 280                 285             


Glu Ser Pro Asp Ala Ala Asn Cys Met Arg Ile Gly Ile Pro Ala Glu 
    290                 295                 300                 


Arg Leu Gly Arg Tyr His Gln Cys Tyr Asn Gly Ser Gly Met Asp Tyr 
305                 310                 315                 320 


Arg Gly Thr Ala Ser Thr Thr Lys Ser Gly His Gln Cys Gln Pro Trp 
                325                 330                 335     


Ala Leu Gln His Pro His Ser His His Leu Ser Ser Thr Asp Phe Pro 
            340                 345                 350         


Glu Leu Gly Gly Gly His Ala Tyr Cys Arg Asn Pro Gly Gly Gln Met 
        355                 360                 365             


Glu Gly Pro Trp Cys Phe Thr Gln Asn Lys Asn Val Arg Met Glu Leu 
    370                 375                 380                 


Cys Asp Val Pro Ser Cys Asp Ser Lys Asp Ser Lys Glu Lys Asn Lys 
385                 390                 395                 400 


Met Glu Ile Leu Tyr Ile Leu Val Pro Ser Val Ala Ile Pro Leu Ala 
                405                 410                 415     


Ile Ala Leu Leu Phe Phe Phe Ile Cys Val Cys Arg Asn Asn Gln Lys 
            420                 425                 430         


Ser Ser Ser Ala Pro Val Gln Arg Gln Pro Lys His Val Arg Gly Gln 
        435                 440                 445             


Asn Val Glu Met Ser Met Leu Asn Ala Tyr Lys Pro Lys Ser Lys Ala 
    450                 455                 460                 


Lys Glu Leu Pro Leu Ser Ala Val Arg Phe Met Glu Glu Leu Gly Glu 
465                 470                 475                 480 


Cys Ala Phe Gly Lys Ile Tyr Lys Gly His Leu Tyr Leu Pro Gly Met 
                485                 490                 495     


Asp His Ala Gln Leu Val Ala Ile Lys Thr Leu Lys Asp Tyr Asn Asn 
            500                 505                 510         


Pro Gln Gln Trp Thr Glu Phe Gln Gln Glu Ala Ser Leu Met Ala Glu 
        515                 520                 525             


Leu His His Pro Asn Ile Val Cys Leu Leu Gly Ala Val Thr Gln Glu 
    530                 535                 540                 


Gln Pro Val Cys Met Leu Phe Glu Tyr Ile Asn Gln Gly Asp Leu His 
545                 550                 555                 560 


Glu Phe Leu Ile Met Arg Ser Pro His Ser Asp Val Gly Cys Ser Ser 
                565                 570                 575     


Asp Glu Asp Gly Thr Val Lys Ser Ser Leu Asp His Gly Asp Phe Leu 
            580                 585                 590         


His Ile Ala Ile Gln Ile Ala Ala Gly Met Glu Tyr Leu Ser Ser His 
        595                 600                 605             


Phe Phe Val His Lys Asp Leu Ala Ala Arg Asn Ile Leu Ile Gly Glu 
    610                 615                 620                 


Gln Leu His Val Lys Ile Ser Asp Leu Gly Leu Ser Arg Glu Ile Tyr 
625                 630                 635                 640 


Ser Ala Asp Tyr Tyr Arg Val Gln Ser Lys Ser Leu Leu Pro Ile Arg 
                645                 650                 655     


Trp Met Pro Pro Glu Ala Ile Met Tyr Gly Lys Phe Ser Ser Asp Ser 
            660                 665                 670         


Asp Ile Trp Ser Phe Gly Val Val Leu Trp Glu Ile Phe Ser Phe Gly 
        675                 680                 685             


Leu Gln Pro Tyr Tyr Gly Phe Ser Asn Gln Glu Val Ile Glu Met Val 
    690                 695                 700                 


Arg Lys Arg Gln Leu Leu Pro Cys Ser Glu Asp Cys Pro Pro Arg Met 
705                 710                 715                 720 


Tyr Ser Leu Met Thr Glu Cys Trp Asn Glu Ile Pro Ser Arg Arg Pro 
                725                 730                 735     


Arg Phe Lys Asp Ile His Val Arg Leu Arg Ser Trp Glu Gly Leu Ser 
            740                 745                 750         


Ser His Thr Ser Ser Thr Thr Pro Ser Gly Gly Asn Ala Thr Thr Gln 
        755                 760                 765             


Thr Thr Ser Leu Ser Ala Ser Pro Val Ser Asn Leu Ser Asn Pro Arg 
    770                 775                 780                 


Tyr Pro Asn Tyr Met Phe Pro Ser Gln Gly Ile Thr Pro Gln Gly Gln 
785                 790                 795                 800 


Ile Ala Gly Phe Ile Gly Pro Pro Ile Pro Gln Asn Gln Arg Phe Ile 
                805                 810                 815     


Pro Ile Asn Gly Tyr Pro Ile Pro Pro Gly Tyr Ala Ala Phe Pro Ala 
            820                 825                 830         


Ala His Tyr Gln Pro Thr Gly Pro Pro Arg Val Ile Gln His Cys Pro 
        835                 840                 845             


Pro Pro Lys Ser Arg Ser Pro Ser Ser Ala Ser Gly Ser Thr Ser Thr 
    850                 855                 860                 


Gly His Val Thr Ser Leu Pro Ser Ser Gly Ser Asn Gln Glu Ala Asn 
865                 870                 875                 880 


Ile Pro Leu Leu Pro His Met Ser Ile Pro Asn His Pro Gly Gly Met 
                885                 890                 895     


Gly Ile Thr Val Phe Gly Asn Lys Ser Gln Lys Pro Tyr Lys Ile Asp 
            900                 905                 910         


Ser Lys Gln Ala Ser Leu Leu Gly Asp Ala Asn Ile His Gly His Thr 
        915                 920                 925             


Glu Ser Met Ile Ser Ala Glu Leu 
    930                 935     


<210>  45
<211>  928
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ROR211

<400>  45

Met Ala Arg Gly Ser Ala Leu Pro Arg Arg Pro Leu Leu Cys Ile Pro 
1               5                   10                  15      


Ala Val Trp Ala Ala Ala Ala Leu Leu Leu Ser Val Ser Arg Thr Ser 
            20                  25                  30          


Gly Glu Val Glu Val Leu Asp Pro Asn Asp Pro Leu Gly Pro Leu Asp 
        35                  40                  45              


Gly Gln Asp Gly Pro Ile Pro Thr Leu Lys Gly Tyr Phe Leu Asn Phe 
    50                  55                  60                  


Leu Glu Pro Val Asn Asn Ile Thr Ile Val Gln Gly Gln Thr Ala Ile 
65                  70                  75                  80  


Leu His Cys Lys Val Ala Gly Asn Pro Pro Pro Asn Val Arg Trp Leu 
                85                  90                  95      


Lys Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Ile Ile Ile Arg 
            100                 105                 110         


Lys Thr Glu Tyr Gly Ser Arg Leu Arg Ile Gln Asp Leu Asp Thr Thr 
        115                 120                 125             


Asp Thr Gly Tyr Tyr Gln Cys Val Ala Thr Val Lys Phe Gly Pro Pro 
    130                 135                 140                 


Pro Thr Ala Ser Pro Gly Tyr Ser Asp Glu Tyr Glu Glu Asp Gly Phe 
145                 150                 155                 160 


Cys Gln Pro Tyr Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg 
                165                 170                 175     


Thr Val Tyr Met Glu Ser Leu His Met Gln Gly Glu Ile Glu Asn Gln 
            180                 185                 190         


Ile Thr Ala Ala Phe Thr Met Ile Gly Thr Ser Ser His Leu Ser Asp 
        195                 200                 205             


Lys Cys Ser Gln Phe Ala Ile Pro Ser Leu Cys His Tyr Ala Phe Pro 
    210                 215                 220                 


Tyr Cys Asp Glu Thr Ser Ser Val Pro Lys Pro Arg Asp Leu Cys Arg 
225                 230                 235                 240 


Asp Glu Cys Glu Ile Leu Glu Asn Val Leu Cys Gln Thr Glu Tyr Ile 
                245                 250                 255     


Phe Ala Arg Ser Asn Pro Met Ile Leu Met Arg Leu Lys Leu Pro Asn 
            260                 265                 270         


Cys Glu Asp Leu Pro Gln Pro Glu Ser Pro Glu Ala Ala Asn Cys Ile 
        275                 280                 285             


Arg Ile Gly Ile Pro Met Ala Asp Pro Ile Asn Lys Asn His Lys Cys 
    290                 295                 300                 


Tyr Asn Ser Thr Gly Val Asp Tyr Arg Gly Thr Val Ser Val Thr Lys 
305                 310                 315                 320 


Ser Gly Arg Gln Cys Gln Pro Trp Asn Ser Gln Tyr Pro His Thr His 
                325                 330                 335     


Thr Phe Thr Ala Leu Arg Phe Pro Glu Leu Asn Gly Gly His Ser Tyr 
            340                 345                 350         


Cys Arg Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Cys Phe Thr Leu 
        355                 360                 365             


Asp Glu Asn Phe Lys Ser Asp Leu Cys Asp Ile Pro Ala Cys Asp Ser 
    370                 375                 380                 


Lys Asp Ser Lys Glu Lys Asn Lys Met Glu Ile Leu Tyr Ile Leu Val 
385                 390                 395                 400 


Pro Ser Val Ala Ile Pro Leu Ala Ile Ala Leu Leu Phe Phe Phe Ile 
                405                 410                 415     


Cys Val Cys Arg Asn Asn Gln Lys Ser Ser Ser Ala Pro Val Gln Arg 
            420                 425                 430         


Gln Pro Lys His Val Arg Gly Gln Asn Val Glu Met Ser Met Leu Asn 
        435                 440                 445             


Ala Tyr Lys Pro Lys Ser Lys Ala Lys Glu Leu Pro Leu Ser Ala Val 
    450                 455                 460                 


Arg Phe Met Glu Glu Leu Gly Glu Cys Ala Phe Gly Lys Ile Tyr Lys 
465                 470                 475                 480 


Gly His Leu Tyr Leu Pro Gly Met Asp His Ala Gln Leu Val Ala Ile 
                485                 490                 495     


Lys Thr Leu Lys Asp Tyr Asn Asn Pro Gln Gln Trp Thr Glu Phe Gln 
            500                 505                 510         


Gln Glu Ala Ser Leu Met Ala Glu Leu His His Pro Asn Ile Val Cys 
        515                 520                 525             


Leu Leu Gly Ala Val Thr Gln Glu Gln Pro Val Cys Met Leu Phe Glu 
    530                 535                 540                 


Tyr Ile Asn Gln Gly Asp Leu His Glu Phe Leu Ile Met Arg Ser Pro 
545                 550                 555                 560 


His Ser Asp Val Gly Cys Ser Ser Asp Glu Asp Gly Thr Val Lys Ser 
                565                 570                 575     


Ser Leu Asp His Gly Asp Phe Leu His Ile Ala Ile Gln Ile Ala Ala 
            580                 585                 590         


Gly Met Glu Tyr Leu Ser Ser His Phe Phe Val His Lys Asp Leu Ala 
        595                 600                 605             


Ala Arg Asn Ile Leu Ile Gly Glu Gln Leu His Val Lys Ile Ser Asp 
    610                 615                 620                 


Leu Gly Leu Ser Arg Glu Ile Tyr Ser Ala Asp Tyr Tyr Arg Val Gln 
625                 630                 635                 640 


Ser Lys Ser Leu Leu Pro Ile Arg Trp Met Pro Pro Glu Ala Ile Met 
                645                 650                 655     


Tyr Gly Lys Phe Ser Ser Asp Ser Asp Ile Trp Ser Phe Gly Val Val 
            660                 665                 670         


Leu Trp Glu Ile Phe Ser Phe Gly Leu Gln Pro Tyr Tyr Gly Phe Ser 
        675                 680                 685             


Asn Gln Glu Val Ile Glu Met Val Arg Lys Arg Gln Leu Leu Pro Cys 
    690                 695                 700                 


Ser Glu Asp Cys Pro Pro Arg Met Tyr Ser Leu Met Thr Glu Cys Trp 
705                 710                 715                 720 


Asn Glu Ile Pro Ser Arg Arg Pro Arg Phe Lys Asp Ile His Val Arg 
                725                 730                 735     


Leu Arg Ser Trp Glu Gly Leu Ser Ser His Thr Ser Ser Thr Thr Pro 
            740                 745                 750         


Ser Gly Gly Asn Ala Thr Thr Gln Thr Thr Ser Leu Ser Ala Ser Pro 
        755                 760                 765             


Val Ser Asn Leu Ser Asn Pro Arg Tyr Pro Asn Tyr Met Phe Pro Ser 
    770                 775                 780                 


Gln Gly Ile Thr Pro Gln Gly Gln Ile Ala Gly Phe Ile Gly Pro Pro 
785                 790                 795                 800 


Ile Pro Gln Asn Gln Arg Phe Ile Pro Ile Asn Gly Tyr Pro Ile Pro 
                805                 810                 815     


Pro Gly Tyr Ala Ala Phe Pro Ala Ala His Tyr Gln Pro Thr Gly Pro 
            820                 825                 830         


Pro Arg Val Ile Gln His Cys Pro Pro Pro Lys Ser Arg Ser Pro Ser 
        835                 840                 845             


Ser Ala Ser Gly Ser Thr Ser Thr Gly His Val Thr Ser Leu Pro Ser 
    850                 855                 860                 


Ser Gly Ser Asn Gln Glu Ala Asn Ile Pro Leu Leu Pro His Met Ser 
865                 870                 875                 880 


Ile Pro Asn His Pro Gly Gly Met Gly Ile Thr Val Phe Gly Asn Lys 
                885                 890                 895     


Ser Gln Lys Pro Tyr Lys Ile Asp Ser Lys Gln Ala Ser Leu Leu Gly 
            900                 905                 910         


Asp Ala Asn Ile His Gly His Thr Glu Ser Met Ile Ser Ala Glu Leu 
        915                 920                 925             


<210>  46
<211>  927
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ROR221

<400>  46

Met His Arg Pro Arg Arg Arg Gly Thr Arg Pro Pro Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Ala Leu Leu Leu Ala Ala Arg Gly Ala Ala Ala Gln Glu Thr 
            20                  25                  30          


Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Leu Lys Gly Tyr Phe 
        35                  40                  45              


Leu Asn Phe Leu Glu Pro Val Asn Asn Ile Thr Ile Val Gln Gly Gln 
    50                  55                  60                  


Thr Ala Ile Leu His Cys Lys Val Ala Gly Asn Pro Pro Pro Asn Val 
65                  70                  75                  80  


Arg Trp Leu Lys Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Ile 
                85                  90                  95      


Ile Ile Arg Lys Thr Glu Tyr Gly Ser Arg Leu Arg Ile Gln Asp Leu 
            100                 105                 110         


Asp Thr Thr Asp Thr Gly Tyr Tyr Gln Cys Val Ala Thr Asn Gly Met 
        115                 120                 125             


Lys Thr Ile Thr Ala Thr Gly Val Leu Phe Val Arg Leu Gly Pro Thr 
    130                 135                 140                 


His Ser Pro Asn His Asn Phe Gln Asp Asp Tyr His Glu Asp Gly Phe 
145                 150                 155                 160 


Cys Gln Pro Tyr Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg 
                165                 170                 175     


Thr Ile Tyr Val Asp Ser Leu Gln Met Gln Gly Glu Ile Glu Asn Arg 
            180                 185                 190         


Ile Thr Ala Ala Phe Thr Met Ile Gly Thr Ser Thr His Leu Ser Asp 
        195                 200                 205             


Gln Cys Ser Gln Phe Ala Ile Pro Ser Phe Cys His Phe Val Phe Pro 
    210                 215                 220                 


Leu Cys Asp Ala Arg Ser Arg Thr Pro Lys Pro Arg Glu Leu Cys Arg 
225                 230                 235                 240 


Asp Glu Cys Glu Val Leu Glu Ser Asp Leu Cys Arg Gln Glu Tyr Thr 
                245                 250                 255     


Ile Ala Arg Ser Asn Pro Leu Ile Leu Met Arg Leu Gln Leu Pro Lys 
            260                 265                 270         


Cys Glu Ala Leu Pro Met Pro Glu Ser Pro Asp Ala Ala Asn Cys Met 
        275                 280                 285             


Arg Ile Ile Pro Met Ala Asp Pro Ile Asn Lys Asn His Lys Cys Tyr 
    290                 295                 300                 


Asn Ser Thr Gly Val Asp Tyr Arg Gly Thr Val Ser Val Thr Lys Ser 
305                 310                 315                 320 


Gly Arg Gln Cys Gln Pro Trp Asn Ser Gln Tyr Pro His Thr His Thr 
                325                 330                 335     


Phe Thr Ala Leu Arg Phe Pro Glu Leu Asn Gly Gly His Ser Tyr Cys 
            340                 345                 350         


Arg Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp 
        355                 360                 365             


Glu Asn Phe Lys Ser Asp Leu Cys Asp Ile Pro Ala Cys Asp Ser Lys 
    370                 375                 380                 


Asp Ser Lys Glu Lys Asn Lys Met Glu Ile Leu Tyr Ile Leu Val Pro 
385                 390                 395                 400 


Ser Val Ala Ile Pro Leu Ala Ile Ala Leu Leu Phe Phe Phe Ile Cys 
                405                 410                 415     


Val Cys Arg Asn Asn Gln Lys Ser Ser Ser Ala Pro Val Gln Arg Gln 
            420                 425                 430         


Pro Lys His Val Arg Gly Gln Asn Val Glu Met Ser Met Leu Asn Ala 
        435                 440                 445             


Tyr Lys Pro Lys Ser Lys Ala Lys Glu Leu Pro Leu Ser Ala Val Arg 
    450                 455                 460                 


Phe Met Glu Glu Leu Gly Glu Cys Ala Phe Gly Lys Ile Tyr Lys Gly 
465                 470                 475                 480 


His Leu Tyr Leu Pro Gly Met Asp His Ala Gln Leu Val Ala Ile Lys 
                485                 490                 495     


Thr Leu Lys Asp Tyr Asn Asn Pro Gln Gln Trp Thr Glu Phe Gln Gln 
            500                 505                 510         


Glu Ala Ser Leu Met Ala Glu Leu His His Pro Asn Ile Val Cys Leu 
        515                 520                 525             


Leu Gly Ala Val Thr Gln Glu Gln Pro Val Cys Met Leu Phe Glu Tyr 
    530                 535                 540                 


Ile Asn Gln Gly Asp Leu His Glu Phe Leu Ile Met Arg Ser Pro His 
545                 550                 555                 560 


Ser Asp Val Gly Cys Ser Ser Asp Glu Asp Gly Thr Val Lys Ser Ser 
                565                 570                 575     


Leu Asp His Gly Asp Phe Leu His Ile Ala Ile Gln Ile Ala Ala Gly 
            580                 585                 590         


Met Glu Tyr Leu Ser Ser His Phe Phe Val His Lys Asp Leu Ala Ala 
        595                 600                 605             


Arg Asn Ile Leu Ile Gly Glu Gln Leu His Val Lys Ile Ser Asp Leu 
    610                 615                 620                 


Gly Leu Ser Arg Glu Ile Tyr Ser Ala Asp Tyr Tyr Arg Val Gln Ser 
625                 630                 635                 640 


Lys Ser Leu Leu Pro Ile Arg Trp Met Pro Pro Glu Ala Ile Met Tyr 
                645                 650                 655     


Gly Lys Phe Ser Ser Asp Ser Asp Ile Trp Ser Phe Gly Val Val Leu 
            660                 665                 670         


Trp Glu Ile Phe Ser Phe Gly Leu Gln Pro Tyr Tyr Gly Phe Ser Asn 
        675                 680                 685             


Gln Glu Val Ile Glu Met Val Arg Lys Arg Gln Leu Leu Pro Cys Ser 
    690                 695                 700                 


Glu Asp Cys Pro Pro Arg Met Tyr Ser Leu Met Thr Glu Cys Trp Asn 
705                 710                 715                 720 


Glu Ile Pro Ser Arg Arg Pro Arg Phe Lys Asp Ile His Val Arg Leu 
                725                 730                 735     


Arg Ser Trp Glu Gly Leu Ser Ser His Thr Ser Ser Thr Thr Pro Ser 
            740                 745                 750         


Gly Gly Asn Ala Thr Thr Gln Thr Thr Ser Leu Ser Ala Ser Pro Val 
        755                 760                 765             


Ser Asn Leu Ser Asn Pro Arg Tyr Pro Asn Tyr Met Phe Pro Ser Gln 
    770                 775                 780                 


Gly Ile Thr Pro Gln Gly Gln Ile Ala Gly Phe Ile Gly Pro Pro Ile 
785                 790                 795                 800 


Pro Gln Asn Gln Arg Phe Ile Pro Ile Asn Gly Tyr Pro Ile Pro Pro 
                805                 810                 815     


Gly Tyr Ala Ala Phe Pro Ala Ala His Tyr Gln Pro Thr Gly Pro Pro 
            820                 825                 830         


Arg Val Ile Gln His Cys Pro Pro Pro Lys Ser Arg Ser Pro Ser Ser 
        835                 840                 845             


Ala Ser Gly Ser Thr Ser Thr Gly His Val Thr Ser Leu Pro Ser Ser 
    850                 855                 860                 


Gly Ser Asn Gln Glu Ala Asn Ile Pro Leu Leu Pro His Met Ser Ile 
865                 870                 875                 880 


Pro Asn His Pro Gly Gly Met Gly Ile Thr Val Phe Gly Asn Lys Ser 
                885                 890                 895     


Gln Lys Pro Tyr Lys Ile Asp Ser Lys Gln Ala Ser Leu Leu Gly Asp 
            900                 905                 910         


Ala Asn Ile His Gly His Thr Glu Ser Met Ile Ser Ala Glu Leu 
        915                 920                 925         


<210>  47
<211>  127
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SITE
<222>  (1)..(127)
<223>  b12_VH

<400>  47

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Gln Ala Ser Gly Tyr Arg Phe Ser Asn Phe 
            20                  25                  30          


Val Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Phe Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Tyr Asn Gly Asn Lys Glu Phe Ser Ala Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Phe Thr Ala Asp Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Pro Tyr Ser Trp Asp Asp Ser Pro Gln Asp Asn Tyr 
            100                 105                 110         


Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Ile Val Ser Ser 
        115                 120                 125         


<210>  48
<211>  108
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SITE
<222>  (1)..(108)
<223>  b12_VL

<400>  48

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Phe Ser Cys Arg Ser Ser His Ser Ile Arg Ser Arg 
            20                  25                  30          


Arg Val Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Val 
        35                  40                  45              


Ile His Gly Val Ser Asn Arg Ala Ser Gly Ile Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Arg Val Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Val Tyr Gly Ala Ser Ser 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Arg Lys 
            100                 105             


<210>  49
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: IgG1-K409R

<400>  49

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  50
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: IgG1-FEA

<400>  50

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Ala Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  51
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD3E27-GSKa

<400>  51

Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Gly Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln 
        35                  40                  45              


Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
    50                  55                  60                  


Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln 
65                  70                  75                  80  


Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg 
                85                  90                  95      


Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
            100                 105                 110         


Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr 
        115                 120                 125             


Tyr Cys Gln Gln Arg Ser Asn Trp Pro Ile Thr Phe Gly Gln Gly Thr 
    130                 135                 140                 


Arg Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
145                 150                 155                 160 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
                165                 170                 175     


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
            180                 185                 190         


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
        195                 200                 205             


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
    210                 215                 220                 


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
225                 230                 235                 240 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
                245                 250                 255 


