                         SEQUENCE LISTING

<110>  Acies Bio d.o.o.
 
<120>  Mesophilic, methylotrophic bacteria for the pH-independent 
       production of biochemicals

<130>  P49905PC00

<150>  EP20199855
<151>  2020-10-02

<160>  92    

<170>  PatentIn version 3.5

<210>  1
<211>  466
<212>  PRT
<213>  Escherichia coli

<400>  1

Met Asp Lys Lys Gln Val Thr Asp Leu Arg Ser Glu Leu Leu Asp Ser 
1               5                   10                  15      


Arg Phe Gly Ala Lys Ser Ile Ser Thr Ile Ala Glu Ser Lys Arg Phe 
            20                  25                  30          


Pro Leu His Glu Met Arg Asp Asp Val Ala Phe Gln Ile Ile Asn Asp 
        35                  40                  45              


Glu Leu Tyr Leu Asp Gly Asn Ala Arg Gln Asn Leu Ala Thr Phe Cys 
    50                  55                  60                  


Gln Thr Trp Asp Asp Glu Asn Val His Lys Leu Met Asp Leu Ser Ile 
65                  70                  75                  80  


Asn Lys Asn Trp Ile Asp Lys Glu Glu Tyr Pro Gln Ser Ala Ala Ile 
                85                  90                  95      


Asp Leu Arg Cys Val Asn Met Val Ala Asp Leu Trp His Ala Pro Ala 
            100                 105                 110         


Pro Lys Asn Gly Gln Ala Val Gly Thr Asn Thr Ile Gly Ser Ser Glu 
        115                 120                 125             


Ala Cys Met Leu Gly Gly Met Ala Met Lys Trp Arg Trp Arg Lys Arg 
    130                 135                 140                 


Met Glu Ala Ala Gly Lys Pro Thr Asp Lys Pro Asn Leu Val Cys Gly 
145                 150                 155                 160 


Pro Val Gln Ile Cys Trp His Lys Phe Ala Arg Tyr Trp Asp Val Glu 
                165                 170                 175     


Leu Arg Glu Ile Pro Met Arg Pro Gly Gln Leu Phe Met Asp Pro Lys 
            180                 185                 190         


Arg Met Ile Glu Ala Cys Asp Glu Asn Thr Ile Gly Val Val Pro Thr 
        195                 200                 205             


Phe Gly Val Thr Tyr Thr Gly Asn Tyr Glu Phe Pro Gln Pro Leu His 
    210                 215                 220                 


Asp Ala Leu Asp Lys Phe Gln Ala Asp Thr Gly Ile Asp Ile Asp Met 
225                 230                 235                 240 


His Ile Asp Ala Ala Ser Gly Gly Phe Leu Ala Pro Phe Val Ala Pro 
                245                 250                 255     


Asp Ile Val Trp Asp Phe Arg Leu Pro Arg Val Lys Ser Ile Ser Ala 
            260                 265                 270         


Ser Gly His Lys Phe Gly Leu Ala Pro Leu Gly Cys Gly Trp Val Ile 
        275                 280                 285             


Trp Arg Asp Glu Glu Ala Leu Pro Gln Glu Leu Val Phe Asn Val Asp 
    290                 295                 300                 


Tyr Leu Gly Gly Gln Ile Gly Thr Phe Ala Ile Asn Phe Ser Arg Pro 
305                 310                 315                 320 


Ala Gly Gln Val Ile Ala Gln Tyr Tyr Glu Phe Leu Arg Leu Gly Arg 
                325                 330                 335     


Glu Gly Tyr Thr Lys Val Gln Asn Ala Ser Tyr Gln Val Ala Ala Tyr 
            340                 345                 350         


Leu Ala Asp Glu Ile Ala Lys Leu Gly Pro Tyr Glu Phe Ile Cys Thr 
        355                 360                 365             


Gly Arg Pro Asp Glu Gly Ile Pro Ala Val Cys Phe Lys Leu Lys Asp 
    370                 375                 380                 


Gly Glu Asp Pro Gly Tyr Thr Leu Tyr Asp Leu Ser Glu Arg Leu Arg 
385                 390                 395                 400 


Leu Arg Gly Trp Gln Val Pro Ala Phe Thr Leu Gly Gly Glu Ala Thr 
                405                 410                 415     


Asp Ile Val Val Met Arg Ile Met Cys Arg Arg Gly Phe Glu Met Asp 
            420                 425                 430         


Phe Ala Glu Leu Leu Leu Glu Asp Tyr Lys Ala Ser Leu Lys Tyr Leu 
        435                 440                 445             


Ser Asp His Pro Lys Leu Gln Gly Ile Ala Gln Gln Asn Ser Phe Lys 
    450                 455                 460                 


His Thr 
465     


<210>  2
<211>  457
<212>  PRT
<213>  Sulfobacillus thermosulfidooxidans

<400>  2

Met Lys Lys Ala Ser Glu Glu Val Ala Ile Asn Pro Leu Phe Ala Arg 
1               5                   10                  15      


Arg Gly Glu Glu Ser Val Pro Arg Tyr Arg Leu Ser Glu Glu Gly Leu 
            20                  25                  30          


Leu Pro Glu Thr Ala Tyr Gln Ile Val His Asp Glu Leu Thr Leu Asp 
        35                  40                  45              


Gly Ser Ala Arg Leu Asn Leu Ala Thr Phe Val Gly Thr Trp Met Glu 
    50                  55                  60                  


Pro Glu Ala Gln Lys Leu Tyr Val Glu Ala Ala Asn Lys Asn Ile Ile 
65                  70                  75                  80  


Asp Lys Asp Glu Tyr Pro Glu Thr Ala Ala Ile Glu Glu Arg Cys Leu 
                85                  90                  95      


Lys Ile Leu Ala Asn Leu Trp Asn Ala Pro Asp Pro Ala Asn Ser Ile 
            100                 105                 110         


Gly Val Ser Thr Thr Gly Ser Ser Glu Ala Cys Met Leu Gly Gly Leu 
        115                 120                 125             


Ala Leu Lys Arg Arg Trp Gln Leu Ser Arg Arg Gln Gln Gly Lys Ser 
    130                 135                 140                 


Thr Asp His Pro Asn Ile Val Phe Ser Ser Ala Val Gln Val Val Trp 
145                 150                 155                 160 


Glu Lys Phe Ala Asn Tyr Phe Glu Val Glu Pro Arg Tyr Val Asn Ile 
                165                 170                 175     


Thr Pro Glu His Pro Tyr Leu Thr Pro Glu Gly Val Ile Lys Ala Val 
            180                 185                 190         


Asp Glu Asn Thr Ile Gly Val Val Pro Ile Leu Gly Val Thr Tyr Thr 
        195                 200                 205             


Gly Ser Tyr Glu Pro Val Glu Ala Ile Ala Gln Ala Leu Asp Asp Leu 
    210                 215                 220                 


Glu Lys Arg Thr Gly Leu Ser Ile Pro Ile Val Asp Ala Ala Ser Gly 
225                 230                 235                 240 


Gly Phe Val Ala Pro Phe Leu Gln Pro Asp Leu Val Trp Asp Phe Arg 
                245                 250                 255     


Leu Pro Arg Val His Ser Ile Asn Thr Ser Gly His Lys Tyr Gly Leu 
            260                 265                 270         


Val Tyr Pro Gly Leu Gly Trp Val Leu Trp Arg Asp Lys Thr Leu Leu 
        275                 280                 285             


Pro Glu Glu Leu Ile Phe Asn Val Ser Tyr Leu Gly Gly Ser Met Pro 
    290                 295                 300                 


Thr Phe Gly Leu Asn Phe Ser Arg Pro Gly Ala Gln Val Leu Leu Gln 
305                 310                 315                 320 


Tyr Tyr Asn Phe Leu Arg Leu Gly Arg Gln Gly Tyr Tyr Thr Val Gln 
                325                 330                 335     


Lys Thr Cys Gln Asn Val Ala His Phe Leu Ala Gln Glu Ile Gly Ala 
            340                 345                 350         


Met Glu Pro Phe Glu Leu Val Thr Asp Gly Ser Asp Leu Pro Val Phe 
        355                 360                 365             


Ala Trp Arg Lys Arg Pro Glu Glu Asn Pro Leu Trp Ser Leu Glu Asp 
    370                 375                 380                 


Leu Ser Phe Val Leu Arg Glu Arg Gly Trp Gln Val Pro Ala Tyr Pro 
385                 390                 395                 400 


Leu Pro Pro Thr Met Gln Asp Val Thr Ile Met Arg Ile Val Val Arg 
                405                 410                 415     


Asn Ser Phe Ser Met Asp Met Ala Gln Leu Phe Leu Asp Asp Leu Asn 
            420                 425                 430         


Arg Ala Val Ala Tyr Leu Gln Gly Leu Asp His Pro Phe Pro Gln Ala 
        435                 440                 445             


Leu Arg Gln His Lys Pro Phe Ala His 
    450                 455         


<210>  3
<211>  467
<212>  PRT
<213>  Bacillus megaterium

<400>  3

Met Pro Gln Trp His Pro His Arg Glu Gln Lys Asn Leu Pro Asp Glu 
1               5                   10                  15      


Phe Pro Val Asn Pro Leu Phe Ser Arg Gln Gly Glu Val Thr Ile Pro 
            20                  25                  30          


Arg Leu Arg Ile Ser Asp Gln Gly Met Leu Pro Glu Thr Ala Tyr Gln 
        35                  40                  45              


Ile Ile His Asp Glu Ile Ala Leu Asp Gly Asn Ala Arg Leu Asn Leu 
    50                  55                  60                  


Ala Thr Phe Val Thr Thr Trp Met Glu Pro Asp Ala Lys Arg Leu Tyr 
65                  70                  75                  80  


Gly Glu Ser Phe Asp Lys Asn Met Ile Asp Lys Asp Glu Tyr Pro Gln 
                85                  90                  95      


Thr Ala Ala Ile Glu Glu Arg Cys Val Arg Ile Leu Ala Asp Leu Trp 
            100                 105                 110         


Asn Ser Pro Asn Pro Asp Thr Thr Met Gly Val Ser Thr Thr Gly Ser 
        115                 120                 125             


Ser Glu Ala Cys Met Leu Gly Gly Leu Ala Leu Lys Arg Arg Trp Gln 
    130                 135                 140                 


Lys Leu Arg Lys Ser Lys Gly Leu Ser Thr Asp Arg Pro Asn Ile Val 
145                 150                 155                 160 


Phe Ser Ser Ser Val Gln Val Val Trp Glu Lys Phe Ala Asn Tyr Trp 
                165                 170                 175     


Asp Val Glu Pro Arg Tyr Val Asn Ile Asn Pro Asp His Pro Tyr Leu 
            180                 185                 190         


Asp Ala Glu Gly Val Ile Asn Ala Val Asp Glu Asn Thr Ile Gly Val 
        195                 200                 205             


Val Pro Ile Leu Gly Val Thr Tyr Thr Gly Val Tyr Glu Pro Ile Ala 
    210                 215                 220                 


Ala Ile Ala Lys Ala Leu Asp Glu Leu Gln Glu Lys Thr Gly Leu Asp 
225                 230                 235                 240 


Ile Pro Ile His Val Asp Ala Ala Ser Gly Gly Phe Ile Ala Pro Phe 
                245                 250                 255     


Leu Gln Pro Asp Leu Ile Trp Asp Phe Arg Leu Pro Arg Val Lys Ser 
            260                 265                 270         


Ile Asn Val Ser Gly His Lys Tyr Gly Leu Val Tyr Pro Gly Leu Gly 
        275                 280                 285             


Trp Val Ile Trp Arg Glu Lys Glu Asp Leu Pro Glu Asp Leu Ile Phe 
    290                 295                 300                 


Arg Val Ser Tyr Leu Gly Gly Asn Met Pro Thr Phe Ala Leu Asn Phe 
305                 310                 315                 320 


Ser Arg Pro Gly Ala Gln Val Leu Leu Gln Tyr Tyr Asn Phe Leu Arg 
                325                 330                 335     


Leu Gly Lys Asp Gly Tyr Tyr Ala Val Gln Lys Thr Ser Gln Glu Asn 
            340                 345                 350         


Ala Leu Phe Leu Ser Lys Glu Ile Gly Glu Met Glu Ala Phe Glu Ile 
        355                 360                 365             


Leu Ala Asp Gly Ser Asp Ile Pro Val Leu Ala Trp Lys Leu Lys Glu 
    370                 375                 380                 


Gly Tyr Thr Pro Asn Trp Thr Leu Tyr Asp Leu Ser Arg Gln Leu Arg 
385                 390                 395                 400 


Thr Tyr Gly Trp Gln Val Pro Ala Tyr Pro Leu Pro Ala Asp Met Glu 
                405                 410                 415     


Glu Ile Thr Ile Met Arg Ile Val Val Arg Asn Gly Phe Ser Arg Asp 
            420                 425                 430         


Leu Ala His Leu Phe Met Val Asn Phe Lys Gln Ala Val Glu Phe Leu 
        435                 440                 445             


Asn Ser Leu Asp Arg Pro Val Leu Lys Asp Thr Lys Tyr Asp Asn Gly 
    450                 455                 460                 


Phe His His 
465         


<210>  4
<211>  467
<212>  PRT
<213>  Listeria innocua

<400>  4

Met Leu Tyr Ser Glu Asn Asp Lys Arg Lys His Glu Ser Tyr Arg Ile 
1               5                   10                  15      


Pro Leu Phe Gly Ser Glu Glu Glu Ser Thr Ser Ile Pro Lys Tyr Val 
            20                  25                  30          


Leu Lys Lys Glu Pro Met Glu Pro Arg Ile Ala Tyr Gln Leu Val Lys 
        35                  40                  45              


Asp Gln Leu Met Asp Glu Gly Asn Ala Arg Gln Asn Leu Ala Thr Phe 
    50                  55                  60                  


Cys Gln Thr Tyr Met Glu Lys Glu Ala Glu Ile Leu Met Ala Glu Thr 
65                  70                  75                  80  


Leu Glu Lys Asn Ala Ile Asp Lys Ser Glu Tyr Pro Gln Thr Ala Glu 
                85                  90                  95      


Leu Glu Asn Arg Cys Val Asn Ile Leu Ala Asp Leu Trp Asn Ala Pro 
            100                 105                 110         


Lys Glu Met Ser Tyr Leu Gly Thr Ser Thr Val Gly Ser Ser Glu Ala 
        115                 120                 125             


Cys Met Leu Gly Gly Leu Ala Met Lys Phe Arg Trp Arg Asn Asn Ala 
    130                 135                 140                 


Glu Lys Arg Gly Leu Asp Ile Gln Ala Lys Arg Pro Asn Leu Ile Ile 
145                 150                 155                 160 


Ser Ser Gly Tyr Gln Val Cys Trp Glu Lys Phe Cys Val Tyr Trp Asp 
                165                 170                 175     


Val Asp Met Arg Val Val Pro Met Asp Lys Glu His Leu Ser Leu Asp 
            180                 185                 190         


Val Glu Lys Val Phe Glu Leu Val Asp Glu Tyr Thr Ile Gly Ile Val 
        195                 200                 205             


Gly Ile Leu Gly Ile Thr Tyr Thr Gly Lys Phe Asp Asp Ile Ala Leu 
    210                 215                 220                 


Leu Asp Glu Lys Val Glu Ala Tyr Asn Glu Ala Asn Glu His Gln Leu 
225                 230                 235                 240 


Val Ile His Ile Asp Gly Ala Ser Gly Ala Met Phe Thr Pro Phe Val 
                245                 250                 255     


Asn Pro Glu Leu Pro Trp Asp Phe Arg Leu Lys Asn Val Val Ser Ile 
            260                 265                 270         


Asn Thr Ser Gly His Lys Tyr Gly Leu Val Tyr Pro Gly Val Gly Trp 
        275                 280                 285             


Ile Leu Trp Lys Asp Lys Glu Tyr Leu Pro Lys Glu Leu Ile Phe Glu 
    290                 295                 300                 


Val Ser Tyr Leu Gly Gly Ser Met Pro Thr Met Ala Ile Asn Phe Ser 
305                 310                 315                 320 


Arg Ser Ala Ser Gln Ile Ile Gly Gln Tyr Tyr Asn Phe Leu Arg Tyr 
                325                 330                 335     


Gly Phe Glu Gly Tyr Arg Glu Ile His Glu Lys Thr Lys Lys Thr Ala 
            340                 345                 350         


Leu Tyr Leu Ser Lys Thr Val Glu Lys Ser Gly Tyr Phe Glu Ile Ile 
        355                 360                 365             


Asn Asp Gly Ser Asn Leu Pro Ile Val Cys Tyr Lys Leu Lys Asp Asp 
    370                 375                 380                 


Leu Asp Val Glu Trp Thr Leu Tyr Asp Leu Ala Asp Gln Leu Leu Met 
385                 390                 395                 400 


Lys Gly Trp Gln Val Pro Ala Tyr Pro Leu Pro Ala Asp Leu Ser Asp 
                405                 410                 415     


Thr Ile Ile Gln Arg Phe Val Cys Arg Ala Asp Leu Gly Tyr Asn Val 
            420                 425                 430         


Ala Glu Glu Phe Ala Ala Asp Phe Ala Asp Ala Leu His Asn Leu Glu 
        435                 440                 445             


His Ala Arg Val Leu Tyr His Asp Lys Glu Arg Asn Asp Ser Tyr Gly 
    450                 455                 460                 


Phe Thr His 
465         


<210>  5
<211>  462
<212>  PRT
<213>  Listeria monocytogenes

<400>  5

Met Phe Lys Thr Asn Val Glu Gln Asn Asn Val Pro Val Phe Gly Ser 
1               5                   10                  15      


Phe Glu Ser Gly Gln Asp Leu Pro Glu Lys Arg Met Asn Lys Glu Ser 
            20                  25                  30          


Val Asp Pro Arg Ile Ala Tyr Gln Leu Val Lys Asp Gln Leu Ile Asp 
        35                  40                  45              


Glu Gly Ser Ala Arg Gln Asn Leu Ala Thr Phe Cys Gln Thr Tyr Met 
    50                  55                  60                  


Glu Pro Glu Ala Glu Gln Ile Met Ala Glu Thr Met Glu Lys Asn Ala 
65                  70                  75                  80  


Ile Asp Lys Ser Glu Tyr Pro Gln Thr Ala Lys Leu Glu Ser Ser Cys 
                85                  90                  95      


Val Asn Met Leu Ala Asp Leu Trp Asn Val Asp Glu Ser Glu His Tyr 
            100                 105                 110         


Met Gly Thr Ser Thr Val Gly Ser Ser Glu Ala Cys Met Leu Gly Gly 
        115                 120                 125             


Met Ala Met Lys Phe Arg Trp Arg Ser Ala Ala Leu Lys Asn Gly Leu 
    130                 135                 140                 


Asp Ile His Ala Lys Lys Pro Ser Leu Val Ile Ser Ser Gly Tyr Gln 
145                 150                 155                 160 


Val Cys Trp Glu Lys Phe Cys Val Tyr Trp Asp Ile Glu Leu Arg Glu 
                165                 170                 175     


Val Pro Met Ser Glu Glu His Leu Ser Ile Asn Thr Asp Ile Ile Met 
            180                 185                 190         


Asp Tyr Val Asp Glu Tyr Thr Ile Gly Ile Val Gly Ile Leu Gly Ile 
        195                 200                 205             


Thr Tyr Thr Gly Lys Phe Asp Asp Ile Met Thr Leu Asn Asp Leu Val 
    210                 215                 220                 


Glu Asp Tyr Asn Asn Thr His Asp Asn Glu Val Val Ile His Val Asp 
225                 230                 235                 240 


Gly Ala Ser Gly Ala Met Phe Thr Pro Phe Val Glu Pro Gly Leu Glu 
                245                 250                 255     


Trp Asp Phe Arg Leu Pro Asn Val Val Ser Ile Asn Thr Ser Gly His 
            260                 265                 270         


Lys Tyr Gly Leu Val Tyr Pro Gly Val Gly Trp Ile Leu Trp Arg Asp 
        275                 280                 285             


Lys Glu Tyr Leu Pro Glu Glu Leu Val Phe Asp Val Ser Tyr Leu Gly 
    290                 295                 300                 


Gly His Met Pro Thr Met Ala Ile Asn Phe Ser Arg Ser Ala Ser Gln 
305                 310                 315                 320 


Ile Ile Gly Gln Tyr Tyr Asn Phe Leu Arg Phe Gly Tyr Glu Gly Tyr 
                325                 330                 335     


Arg Gln Ile His Met Arg Thr Arg Asp Gly Ala Leu Gln Leu Ser Gln 
            340                 345                 350         


Ala Val Ala Glu Thr Gly Leu Phe Glu Ile Tyr Asn Asp Gly Ala Asn 
        355                 360                 365             


Leu Pro Ile Val Cys Tyr Lys Leu Lys Asp Asp Ala Asn Val Ala Trp 
    370                 375                 380                 


Thr Leu Tyr Asp Leu Ala Asp Arg Leu Gln Met Lys Gly Trp Gln Val 
385                 390                 395                 400 


Pro Ala Tyr Pro Leu Pro Lys Glu Met Gly Asn Thr Ile Ile Gln Arg 
                405                 410                 415     


Tyr Val Cys Arg Gly Asp Leu Gly Gln Asn Met Val Thr Ala Phe Lys 
            420                 425                 430         


Asn Asp Leu Ser Glu Ser Ile Glu Glu Leu Asn Asn Ala His Ile Leu 
        435                 440                 445             


Tyr His Asp Val Asn Thr Ser Lys Thr His Gly Phe Thr His 
    450                 455                 460         


<210>  6
<211>  466
<212>  PRT
<213>  Shigella flexneri

<400>  6

Met Asp Gln Lys Leu Leu Thr Asp Phe Arg Ser Glu Leu Leu Asp Ser 
1               5                   10                  15      


Arg Phe Gly Ala Lys Ala Ile Ser Thr Ile Ala Glu Ser Lys Arg Phe 
            20                  25                  30          


Pro Leu His Glu Met Arg Asp Asp Val Ala Phe Gln Ile Ile Asn Asp 
        35                  40                  45              


Glu Leu Tyr Leu Asp Gly Asn Ala Arg Gln Asn Leu Ala Thr Phe Cys 
    50                  55                  60                  


Gln Thr Trp Asp Asp Glu Asn Val His Lys Leu Met Asp Leu Ser Ile 
65                  70                  75                  80  


Asn Lys Asn Trp Ile Asp Lys Glu Glu Tyr Pro Gln Ser Ala Ala Ile 
                85                  90                  95      


Asp Leu Arg Cys Val Asn Met Val Ala Asp Leu Trp His Ala Pro Ala 
            100                 105                 110         


Pro Lys Asn Gly Gln Ala Val Gly Thr Asn Thr Ile Gly Ser Ser Glu 
        115                 120                 125             


Ala Cys Met Leu Gly Gly Met Ala Met Lys Trp Arg Trp Arg Lys Arg 
    130                 135                 140                 


Met Glu Ala Ala Gly Lys Pro Thr Asp Lys Pro Asn Leu Val Cys Gly 
145                 150                 155                 160 


Pro Val Gln Ile Cys Trp His Lys Phe Ala Arg Tyr Trp Asp Val Glu 
                165                 170                 175     


Leu Arg Glu Ile Pro Met Arg Pro Gly Gln Leu Phe Met Asp Pro Lys 
            180                 185                 190         


Arg Met Ile Glu Ala Cys Asp Glu Asn Thr Ile Gly Val Val Pro Thr 
        195                 200                 205             


Phe Gly Val Thr Tyr Thr Gly Asn Tyr Glu Phe Pro Gln Pro Leu His 
    210                 215                 220                 


Asp Ala Leu Asp Lys Phe Gln Ala Asp Thr Gly Ile Asp Ile Asp Met 
225                 230                 235                 240 


His Ile Asp Ala Ala Ser Gly Gly Phe Leu Ala Pro Phe Val Ala Pro 
                245                 250                 255     


Asp Ile Val Trp Asp Phe Arg Leu Pro Arg Val Lys Ser Ile Ser Ala 
            260                 265                 270         


Ser Gly His Lys Phe Gly Leu Ala Pro Leu Gly Cys Gly Trp Val Ile 
        275                 280                 285             


Trp Arg Asp Glu Glu Ala Leu Pro Gln Glu Leu Val Phe Asn Val Asp 
    290                 295                 300                 


Tyr Leu Gly Gly Gln Ile Gly Thr Phe Ala Ile Asn Phe Ser Arg Pro 
305                 310                 315                 320 


Ala Gly Gln Val Ile Ala Gln Tyr Tyr Glu Phe Leu Arg Leu Gly Arg 
                325                 330                 335     


Glu Gly Tyr Thr Lys Val Gln Asn Ala Ser Tyr Gln Val Ala Ala Tyr 
            340                 345                 350         


Leu Ala Asp Glu Ile Ala Lys Gln Gly Pro Tyr Glu Phe Ile Cys Thr 
        355                 360                 365             


Gly Arg Pro Asp Glu Gly Ile Pro Ala Val Cys Phe Lys Leu Lys Asp 
    370                 375                 380                 


Gly Glu Asp Pro Gly Tyr Thr Leu Tyr Asp Leu Ser Glu Arg Leu Arg 
385                 390                 395                 400 


Leu Arg Gly Trp Gln Val Pro Ala Phe Thr Leu Gly Gly Glu Ala Thr 
                405                 410                 415     


Asp Ile Val Val Met Arg Ile Met Cys Arg Arg Gly Phe Glu Met Asp 
            420                 425                 430         


Phe Ala Glu Leu Leu Leu Glu Asp Tyr Lys Ala Ser Leu Lys Tyr Leu 
        435                 440                 445             


Ser Asp His Pro Lys Leu Gln Gly Ile Ala Gln Gln Asn Ser Phe Lys 
    450                 455                 460                 


His Thr 
465     


<210>  7
<211>  466
<212>  PRT
<213>  Lactococcus lactis subsp. lactis

<400>  7

Met Leu Tyr Gly Lys Glu Asn Arg Asp Glu Ala Glu Phe Leu Glu Pro 
1               5                   10                  15      


Ile Phe Gly Ser Glu Ser Glu Gln Val Asp Leu Pro Lys Tyr Lys Leu 
            20                  25                  30          


Ala Gln Gln Ser Ile Glu Pro Arg Val Ala Tyr Gln Leu Val Gln Asp 
        35                  40                  45              


Glu Met Leu Asp Glu Gly Asn Ala Arg Leu Asn Leu Ala Thr Phe Cys 
    50                  55                  60                  


Gln Thr Tyr Met Glu Pro Glu Ala Val Lys Leu Met Ser Gln Thr Leu 
65                  70                  75                  80  


Glu Lys Asn Ala Ile Asp Lys Ser Glu Tyr Pro Arg Thr Thr Glu Ile 
                85                  90                  95      


Glu Asn Arg Cys Val Asn Met Ile Ala Asp Leu Trp Asn Ala Ser Glu 
            100                 105                 110         


Lys Glu Lys Phe Met Gly Thr Ser Thr Ile Gly Ser Ser Glu Ala Cys 
        115                 120                 125             


Met Leu Gly Gly Met Ala Met Lys Phe Ser Trp Arg Lys Arg Ala Glu 
    130                 135                 140                 


Lys Leu Gly Leu Asp Ile Asn Ala Lys Lys Pro Asn Leu Val Ile Ser 
145                 150                 155                 160 


Ser Gly Tyr Gln Val Cys Trp Glu Lys Phe Cys Ile Tyr Trp Asp Ile 
                165                 170                 175     


Glu Met Arg Glu Val Pro Met Asp Lys Glu His Met Ser Ile Asn Leu 
            180                 185                 190         


Asp Lys Val Met Asp Tyr Val Asp Glu Tyr Thr Ile Gly Val Val Gly 
        195                 200                 205             


Ile Met Gly Ile Thr Tyr Thr Gly Arg Tyr Asp Asp Ile Lys Ala Leu 
    210                 215                 220                 


Asp Asn Leu Ile Glu Glu Tyr Asn Lys Gln Thr Asp Tyr Lys Val Tyr 
225                 230                 235                 240 


Ile His Val Asp Ala Ala Ser Gly Gly Leu Tyr Ala Pro Phe Val Glu 
                245                 250                 255     


Pro Glu Leu Glu Trp Asp Phe Arg Leu Lys Asn Val Ile Ser Ile Asn 
            260                 265                 270         


Thr Ser Gly His Lys Tyr Gly Leu Val Tyr Pro Gly Val Gly Trp Val 
        275                 280                 285             


Leu Trp Arg Asp Lys Lys Tyr Leu Pro Glu Glu Leu Ile Phe Lys Val 
    290                 295                 300                 


Ser Tyr Leu Gly Gly Glu Leu Pro Thr Met Ala Ile Asn Phe Ser His 
305                 310                 315                 320 


Ser Ala Ser Gln Leu Ile Gly Gln Tyr Tyr Asn Phe Val Arg Tyr Gly 
                325                 330                 335     


Phe Asp Gly Tyr Lys Ala Ile His Glu Arg Thr His Lys Val Ala Met 
            340                 345                 350         


Phe Leu Ala Lys Glu Ile Glu Lys Thr Gly Met Phe Glu Ile Met Asn 
        355                 360                 365             


Asp Gly Ser Gln Leu Pro Ile Val Cys Tyr Lys Leu Lys Glu Asp Ser 
    370                 375                 380                 


Asn Arg Gly Trp Asn Leu Tyr Asp Leu Ala Asp Arg Leu Leu Met Lys 
385                 390                 395                 400 


Gly Trp Gln Val Pro Ala Tyr Pro Leu Pro Lys Asn Leu Glu Asn Glu 
                405                 410                 415     


Ile Ile Gln Arg Leu Val Ile Arg Ala Asp Phe Gly Met Asn Met Ala 
            420                 425                 430         


Phe Asn Tyr Val Gln Asp Met Gln Glu Ala Ile Glu Ala Leu Asn Lys 
        435                 440                 445             


Ala His Ile Leu Tyr His Glu Glu Pro Glu Asn Lys Thr Tyr Gly Phe 
    450                 455                 460                 


Thr His 
465     


<210>  8
<211>  466
<212>  PRT
<213>  Lactococcus lactis subsp. cremoris

<400>  8

Met Leu Tyr Gly Lys Glu Asn Arg Asp Glu Ala Glu Phe Leu Glu Pro 
1               5                   10                  15      


Ile Phe Gly Ser Glu Ser Glu Gln Val Asp Leu Pro Lys Tyr Lys Leu 
            20                  25                  30          


Ala Gln Gln Ser Ile Glu Pro Arg Val Ala Tyr Gln Leu Val Gln Asp 
        35                  40                  45              


Glu Met Leu Asp Glu Gly Asn Ala Arg Leu Asn Leu Ala Thr Phe Cys 
    50                  55                  60                  


Gln Thr Tyr Met Glu Pro Glu Ala Val Lys Leu Met Ser Gln Thr Leu 
65                  70                  75                  80  


Glu Lys Asn Ala Ile Asp Lys Ser Glu Tyr Pro Arg Thr Thr Glu Ile 
                85                  90                  95      


Glu Asn Arg Cys Val Asn Met Ile Ala Asp Leu Trp Asn Ala Ser Glu 
            100                 105                 110         


Lys Glu Lys Phe Met Gly Thr Ser Thr Ile Gly Ser Ser Glu Ala Cys 
        115                 120                 125             


Met Leu Gly Gly Met Ala Met Lys Phe Ser Trp Arg Lys Arg Ala Glu 
    130                 135                 140                 


Lys Leu Gly Leu Asp Ile Asn Ala Lys Lys Pro Asn Leu Val Ile Ser 
145                 150                 155                 160 


Ser Gly Tyr Gln Val Cys Trp Glu Lys Phe Cys Val Tyr Trp Asp Ile 
                165                 170                 175     


Glu Met Arg Glu Val Pro Met Asp Arg Glu His Met Ser Ile Asn Leu 
            180                 185                 190         


Glu Lys Val Met Asp Tyr Val Asp Glu Tyr Thr Ile Gly Val Val Gly 
        195                 200                 205             


Ile Met Gly Ile Thr Tyr Thr Gly Arg Tyr Asp Asp Ile Lys Ala Leu 
    210                 215                 220                 


Asp Asn Leu Ile Glu Glu Tyr Asn Lys Gln Thr Asp Tyr Lys Val Tyr 
225                 230                 235                 240 


Ile His Val Asp Ala Ala Ser Gly Gly Leu Tyr Ala Pro Phe Val Glu 
                245                 250                 255     


Pro Glu Leu Glu Trp Asp Phe Arg Leu Lys Asn Val Ile Ser Ile Asn 
            260                 265                 270         


Thr Ser Gly His Lys Tyr Gly Leu Val Tyr Pro Gly Val Gly Trp Val 
        275                 280                 285             


Leu Trp Arg Asp Lys Lys Tyr Leu Pro Glu Glu Leu Ile Phe Lys Val 
    290                 295                 300                 


Ser Tyr Leu Gly Gly Glu Leu Pro Thr Met Ala Ile Asn Phe Ser His 
305                 310                 315                 320 


Ser Ala Ser Gln Leu Ile Gly Gln Tyr Tyr Asn Phe Val Arg Tyr Gly 
                325                 330                 335     


Phe Asp Gly Tyr Lys Ala Ile His Glu Arg Thr His Lys Val Ala Met 
            340                 345                 350         


Tyr Leu Ala Glu Glu Ile Glu Lys Thr Gly Met Phe Glu Ile Met Asn 
        355                 360                 365             


Asp Gly Ala Gln Leu Pro Ile Val Cys Tyr Lys Leu Lys Glu Asn Ser 
    370                 375                 380                 


Asn Arg Gly Trp Asn Leu Tyr Asp Leu Ala Asp Arg Leu Leu Met Lys 
385                 390                 395                 400 


Gly Trp Gln Val Pro Ala Tyr Pro Leu Pro Lys Asn Leu Glu Asn Glu 
                405                 410                 415     


Ile Ile Gln Arg Leu Val Ile Arg Ala Asp Phe Gly Met Asn Met Ala 
            420                 425                 430         


Phe Asn Tyr Val Gln Asp Met Gln Glu Ala Ile Asp Ala Leu Asn Lys 
        435                 440                 445             


Ala His Ile Leu Phe His Gln Glu Pro Glu Asn Lys Thr Tyr Gly Phe 
    450                 455                 460                 


Thr His 
465     


<210>  9
<211>  464
<212>  PRT
<213>  Aliivibrio fischeri

<400>  9

Met Pro Leu His Ser Lys Asn Ala Val Arg Asp Asp Leu Leu Asp Asp 
1               5                   10                  15      


Ile Tyr Ser Ser Ala Asp Leu Ser Leu Ser Met Pro Lys Tyr Lys Met 
            20                  25                  30          


Pro Glu Gln Glu His Asp Pro Arg His Ala Tyr Gln Val Ile His Asp 
        35                  40                  45              


Glu Leu Met Met Asp Gly Asn Ser Arg Gln Asn Leu Ala Thr Phe Cys 
    50                  55                  60                  


Gln Thr Trp Val Glu Asp Glu Val His Lys Leu Met Asp Glu Cys Ile 
65                  70                  75                  80  


Asp Lys Asn Met Ile Asp Lys Asp Glu Tyr Pro Gln Thr Ala Glu Leu 
                85                  90                  95      


Glu Ser Arg Cys Val His Met Leu Ala Asp Leu Trp Asn Ser Pro Asp 
            100                 105                 110         


Ala Glu Asn Thr Leu Gly Cys Ser Thr Thr Gly Ser Ser Glu Ala Ala 
        115                 120                 125             


Met Leu Gly Gly Met Ala Leu Lys Trp Ala Trp Arg Glu Lys Met Lys 
    130                 135                 140                 


Lys Leu Gly Lys Pro Thr Asp Lys Pro Asn Met Ile Cys Gly Pro Val 
145                 150                 155                 160 


Gln Val Cys Trp His Lys Phe Ala Arg Tyr Trp Asp Ile Glu Leu Arg 
                165                 170                 175     


Glu Ile Pro Met Glu Gly Asp Arg Leu Ile Met Thr Pro Glu Glu Val 
            180                 185                 190         


Ile Lys Arg Cys Asp Glu Asn Thr Ile Gly Val Val Pro Thr Leu Gly 
        195                 200                 205             


Val Thr Phe Thr Cys Gln Tyr Glu Pro Val Lys Ala Val His Glu Ala 
    210                 215                 220                 


Leu Asp Lys Leu Gln Glu Glu Thr Gly Leu Asp Ile Pro Met His Ile 
225                 230                 235                 240 


Asp Ala Ala Ser Gly Gly Phe Leu Ala Pro Phe Cys Asp Pro Asp Leu 
                245                 250                 255     


Glu Trp Asp Phe Arg Leu Pro Arg Val Lys Ser Ile Asn Ala Ser Gly 
            260                 265                 270         


His Lys Phe Gly Leu Ser Pro Leu Gly Val Gly Trp Val Ile Trp Arg 
        275                 280                 285             


Asp Ala Ser Ala Leu His Glu Asp Leu Ile Phe Asn Val Asn Tyr Leu 
    290                 295                 300                 


Gly Gly Asn Met Pro Thr Phe Ala Leu Asn Phe Ser Arg Pro Gly Gly 
305                 310                 315                 320 


Gln Ile Val Ala Gln Tyr Tyr Asn Phe Leu Arg Leu Gly Lys Glu Gly 
                325                 330                 335     


Tyr Arg Lys Ile His Gln Ala Cys Tyr Asp Thr Ala Val Tyr Leu Ser 
            340                 345                 350         


Ser Glu Ile Glu Lys Leu Gly Met Phe Glu Ile Ile Tyr Asp Gly Lys 
        355                 360                 365             


Gly Gly Ile Pro Ala Met Ser Trp Ser Leu Lys Glu Gly Val Asp Pro 
    370                 375                 380                 


Gly Phe Asn Leu Phe Asp Leu Ser Asp Arg Ile Arg Ser Arg Gly Trp 
385                 390                 395                 400 


Gln Ile Ala Ala Tyr Ala Met Pro Pro Lys Arg Glu Asp Leu Val Ile 
                405                 410                 415     


Met Arg Ile Leu Val Arg His Gly Phe Ser Arg Asp Gln Ala Asp Leu 
            420                 425                 430         


Leu Val Ala Asp Leu Lys His Cys Val Glu Phe Phe Ala Lys His Pro 
        435                 440                 445             


Ile Ser His Gly Ser Asp Glu Leu Glu Ser Ser Gly Phe Asn His Gly 
    450                 455                 460                 


<210>  10
<211>  468
<212>  PRT
<213>  Lactobacillus brevis

<400>  10

Met Ala Met Leu Tyr Gly Lys His Thr His Glu Thr Asp Glu Thr Leu 
1               5                   10                  15      


Thr Pro Ile Phe Gly Ala Thr Ala Glu Arg His Asp Leu Pro Lys Tyr 
            20                  25                  30          


Lys Leu Ala Lys His Ala Leu Glu Pro Arg Glu Ala Asp Arg Leu Val 
        35                  40                  45              


Arg Asp Gln Leu Leu Asp Glu Gly Asn Ser Arg Leu Asn Leu Ala Thr 
    50                  55                  60                  


Phe Cys Gln Thr Tyr Met Glu Pro Glu Ala Val Glu Leu Met Lys Asp 
65                  70                  75                  80  


Thr Leu Glu Lys Asn Ala Ile Asp Lys Ser Glu Tyr Pro Arg Thr Ala 
                85                  90                  95      


Glu Ile Glu Asn Arg Cys Val Asn Ile Ile Ala Asn Leu Trp His Ala 
            100                 105                 110         


Pro Glu Ala Glu Ser Phe Thr Gly Thr Ser Thr Ile Gly Ser Ser Glu 
        115                 120                 125             


Ala Cys Met Leu Ala Gly Leu Ala Met Lys Phe Ala Trp Arg Lys Arg 
    130                 135                 140                 


Ala Lys Ala Asn Gly Leu Asp Leu Thr Ala His Gln Pro Asn Ile Val 
145                 150                 155                 160 


Ile Ser Ala Gly Tyr Gln Val Cys Trp Glu Lys Phe Cys Val Tyr Trp 
                165                 170                 175     


Asp Ile Asp Met His Val Val Pro Met Asp Asp Asp His Met Ser Leu 
            180                 185                 190         


Asn Val Asp His Val Leu Asp Tyr Val Asp Asp Tyr Thr Ile Gly Ile 
        195                 200                 205             


Val Gly Ile Met Gly Ile Thr Tyr Thr Gly Gln Tyr Asp Asp Leu Ala 
    210                 215                 220                 


Arg Leu Asp Ala Val Val Glu Arg Tyr Asn Arg Thr Thr Lys Phe Pro 
225                 230                 235                 240 


Val Tyr Ile His Val Asp Ala Ala Ser Gly Gly Phe Tyr Thr Pro Phe 
                245                 250                 255     


Ile Glu Pro Glu Leu Lys Trp Asp Phe Arg Leu Asn Asn Val Ile Ser 
            260                 265                 270         


Ile Asn Ala Ser Gly His Lys Tyr Gly Leu Val Tyr Pro Gly Val Gly 
        275                 280                 285             


Trp Val Ile Trp Arg Asp Gln Gln Tyr Leu Pro Lys Glu Leu Val Phe 
    290                 295                 300                 


Lys Val Ser Tyr Leu Gly Gly Glu Leu Pro Thr Met Ala Ile Asn Phe 
305                 310                 315                 320 


Ser His Ser Ala Ser Gln Leu Ile Gly Gln Tyr Tyr Asn Phe Ile Arg 
                325                 330                 335     


Phe Gly Phe Asp Gly Tyr Arg Glu Ile Gln Glu Lys Thr His Asp Val 
            340                 345                 350         


Ala Arg Tyr Leu Ala Lys Ser Leu Thr Lys Leu Gly Gly Phe Ser Leu 
        355                 360                 365             


Ile Asn Asp Gly His Glu Leu Pro Leu Ile Cys Tyr Glu Leu Thr Ala 
    370                 375                 380                 


Asp Ser Asp Arg Glu Trp Thr Leu Tyr Asp Leu Ser Asp Arg Leu Leu 
385                 390                 395                 400 


Met Lys Gly Trp Gln Val Pro Thr Tyr Pro Leu Pro Lys Asn Met Thr 
                405                 410                 415     


Asp Arg Val Ile Gln Arg Ile Val Val Arg Ala Asp Phe Gly Met Ser 
            420                 425                 430         


Met Ala His Asp Phe Ile Asp Asp Leu Thr Gln Ala Ile His Asp Leu 
        435                 440                 445             


Asp Gln Ala His Ile Val Phe His Ser Asp Pro Gln Pro Lys Lys Tyr 
    450                 455                 460                 


Gly Phe Thr His 
465             


<210>  11
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E. coli GAD mutant E89Q

<400>  11

Met Asp Lys Lys Gln Val Thr Asp Leu Arg Ser Glu Leu Leu Asp Ser 
1               5                   10                  15      


Arg Phe Gly Ala Lys Ser Ile Ser Thr Ile Ala Glu Ser Lys Arg Phe 
            20                  25                  30          


Pro Leu His Glu Met Arg Asp Asp Val Ala Phe Gln Ile Ile Asn Asp 
        35                  40                  45              


Glu Leu Tyr Leu Asp Gly Asn Ala Arg Gln Asn Leu Ala Thr Phe Cys 
    50                  55                  60                  


Gln Thr Trp Asp Asp Glu Asn Val His Lys Leu Met Asp Leu Ser Ile 
65                  70                  75                  80  


Asn Lys Asn Trp Ile Asp Lys Glu Gln Tyr Pro Gln Ser Ala Ala Ile 
                85                  90                  95      


Asp Leu Arg Cys Val Asn Met Val Ala Asp Leu Trp His Ala Pro Ala 
            100                 105                 110         


Pro Lys Asn Gly Gln Ala Val Gly Thr Asn Thr Ile Gly Ser Ser Glu 
        115                 120                 125             


Ala Cys Met Leu Gly Gly Met Ala Met Lys Trp Arg Trp Arg Lys Arg 
    130                 135                 140                 


Met Glu Ala Ala Gly Lys Pro Thr Asp Lys Pro Asn Leu Val Cys Gly 
145                 150                 155                 160 


Pro Val Gln Ile Cys Trp His Lys Phe Ala Arg Tyr Trp Asp Val Glu 
                165                 170                 175     


Leu Arg Glu Ile Pro Met Arg Pro Gly Gln Leu Phe Met Asp Pro Lys 
            180                 185                 190         


Arg Met Ile Glu Ala Cys Asp Glu Asn Thr Ile Gly Val Val Pro Thr 
        195                 200                 205             


Phe Gly Val Thr Tyr Thr Gly Asn Tyr Glu Phe Pro Gln Pro Leu His 
    210                 215                 220                 


Asp Ala Leu Asp Lys Phe Gln Ala Asp Thr Gly Ile Asp Ile Asp Met 
225                 230                 235                 240 


His Ile Asp Ala Ala Ser Gly Gly Phe Leu Ala Pro Phe Val Ala Pro 
                245                 250                 255     


Asp Ile Val Trp Asp Phe Arg Leu Pro Arg Val Lys Ser Ile Ser Ala 
            260                 265                 270         


Ser Gly His Lys Phe Gly Leu Ala Pro Leu Gly Cys Gly Trp Val Ile 
        275                 280                 285             


Trp Arg Asp Glu Glu Ala Leu Pro Gln Glu Leu Val Phe Asn Val Asp 
    290                 295                 300                 


Tyr Leu Gly Gly Gln Ile Gly Thr Phe Ala Ile Asn Phe Ser Arg Pro 
305                 310                 315                 320 


Ala Gly Gln Val Ile Ala Gln Tyr Tyr Glu Phe Leu Arg Leu Gly Arg 
                325                 330                 335     


Glu Gly Tyr Thr Lys Val Gln Asn Ala Ser Tyr Gln Val Ala Ala Tyr 
            340                 345                 350         


Leu Ala Asp Glu Ile Ala Lys Leu Gly Pro Tyr Glu Phe Ile Cys Thr 
        355                 360                 365             


Gly Arg Pro Asp Glu Gly Ile Pro Ala Val Cys Phe Lys Leu Lys Asp 
    370                 375                 380                 


Gly Glu Asp Pro Gly Tyr Thr Leu Tyr Asp Leu Ser Glu Arg Leu Arg 
385                 390                 395                 400 


Leu Arg Gly Trp Gln Val Pro Ala Phe Thr Leu Gly Gly Glu Ala Thr 
                405                 410                 415     


Asp Ile Val Val Met Arg Ile Met Cys Arg Arg Gly Phe Glu Met Asp 
            420                 425                 430         


Phe Ala Glu Leu Leu Leu Glu Asp Tyr Lys Ala Ser Leu Lys Tyr Leu 
        435                 440                 445             


Ser Asp His Pro Lys Leu Gln Gly Ile Ala Gln Gln Asn Ser Phe Lys 
    450                 455                 460                 


His Thr 
465     


<210>  12
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E. coli GAD mutant H465A

<400>  12

Met Asp Lys Lys Gln Val Thr Asp Leu Arg Ser Glu Leu Leu Asp Ser 
1               5                   10                  15      


Arg Phe Gly Ala Lys Ser Ile Ser Thr Ile Ala Glu Ser Lys Arg Phe 
            20                  25                  30          


Pro Leu His Glu Met Arg Asp Asp Val Ala Phe Gln Ile Ile Asn Asp 
        35                  40                  45              


Glu Leu Tyr Leu Asp Gly Asn Ala Arg Gln Asn Leu Ala Thr Phe Cys 
    50                  55                  60                  


Gln Thr Trp Asp Asp Glu Asn Val His Lys Leu Met Asp Leu Ser Ile 
65                  70                  75                  80  


Asn Lys Asn Trp Ile Asp Lys Glu Glu Tyr Pro Gln Ser Ala Ala Ile 
                85                  90                  95      


Asp Leu Arg Cys Val Asn Met Val Ala Asp Leu Trp His Ala Pro Ala 
            100                 105                 110         


Pro Lys Asn Gly Gln Ala Val Gly Thr Asn Thr Ile Gly Ser Ser Glu 
        115                 120                 125             


Ala Cys Met Leu Gly Gly Met Ala Met Lys Trp Arg Trp Arg Lys Arg 
    130                 135                 140                 


Met Glu Ala Ala Gly Lys Pro Thr Asp Lys Pro Asn Leu Val Cys Gly 
145                 150                 155                 160 


Pro Val Gln Ile Cys Trp His Lys Phe Ala Arg Tyr Trp Asp Val Glu 
                165                 170                 175     


Leu Arg Glu Ile Pro Met Arg Pro Gly Gln Leu Phe Met Asp Pro Lys 
            180                 185                 190         


Arg Met Ile Glu Ala Cys Asp Glu Asn Thr Ile Gly Val Val Pro Thr 
        195                 200                 205             


Phe Gly Val Thr Tyr Thr Gly Asn Tyr Glu Phe Pro Gln Pro Leu His 
    210                 215                 220                 


Asp Ala Leu Asp Lys Phe Gln Ala Asp Thr Gly Ile Asp Ile Asp Met 
225                 230                 235                 240 


His Ile Asp Ala Ala Ser Gly Gly Phe Leu Ala Pro Phe Val Ala Pro 
                245                 250                 255     


Asp Ile Val Trp Asp Phe Arg Leu Pro Arg Val Lys Ser Ile Ser Ala 
            260                 265                 270         


Ser Gly His Lys Phe Gly Leu Ala Pro Leu Gly Cys Gly Trp Val Ile 
        275                 280                 285             


Trp Arg Asp Glu Glu Ala Leu Pro Gln Glu Leu Val Phe Asn Val Asp 
    290                 295                 300                 


Tyr Leu Gly Gly Gln Ile Gly Thr Phe Ala Ile Asn Phe Ser Arg Pro 
305                 310                 315                 320 


Ala Gly Gln Val Ile Ala Gln Tyr Tyr Glu Phe Leu Arg Leu Gly Arg 
                325                 330                 335     


Glu Gly Tyr Thr Lys Val Gln Asn Ala Ser Tyr Gln Val Ala Ala Tyr 
            340                 345                 350         


Leu Ala Asp Glu Ile Ala Lys Leu Gly Pro Tyr Glu Phe Ile Cys Thr 
        355                 360                 365             


Gly Arg Pro Asp Glu Gly Ile Pro Ala Val Cys Phe Lys Leu Lys Asp 
    370                 375                 380                 


Gly Glu Asp Pro Gly Tyr Thr Leu Tyr Asp Leu Ser Glu Arg Leu Arg 
385                 390                 395                 400 


Leu Arg Gly Trp Gln Val Pro Ala Phe Thr Leu Gly Gly Glu Ala Thr 
                405                 410                 415     


Asp Ile Val Val Met Arg Ile Met Cys Arg Arg Gly Phe Glu Met Asp 
            420                 425                 430         


Phe Ala Glu Leu Leu Leu Glu Asp Tyr Lys Ala Ser Leu Lys Tyr Leu 
        435                 440                 445             


Ser Asp His Pro Lys Leu Gln Gly Ile Ala Gln Gln Asn Ser Phe Lys 
    450                 455                 460                 


Ala Thr 
465     


<210>  13
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E. coli GAD mutant E89Q+H465A

<400>  13

Met Asp Lys Lys Gln Val Thr Asp Leu Arg Ser Glu Leu Leu Asp Ser 
1               5                   10                  15      


Arg Phe Gly Ala Lys Ser Ile Ser Thr Ile Ala Glu Ser Lys Arg Phe 
            20                  25                  30          


Pro Leu His Glu Met Arg Asp Asp Val Ala Phe Gln Ile Ile Asn Asp 
        35                  40                  45              


Glu Leu Tyr Leu Asp Gly Asn Ala Arg Gln Asn Leu Ala Thr Phe Cys 
    50                  55                  60                  


Gln Thr Trp Asp Asp Glu Asn Val His Lys Leu Met Asp Leu Ser Ile 
65                  70                  75                  80  


Asn Lys Asn Trp Ile Asp Lys Glu Gln Tyr Pro Gln Ser Ala Ala Ile 
                85                  90                  95      


Asp Leu Arg Cys Val Asn Met Val Ala Asp Leu Trp His Ala Pro Ala 
            100                 105                 110         


Pro Lys Asn Gly Gln Ala Val Gly Thr Asn Thr Ile Gly Ser Ser Glu 
        115                 120                 125             


Ala Cys Met Leu Gly Gly Met Ala Met Lys Trp Arg Trp Arg Lys Arg 
    130                 135                 140                 


Met Glu Ala Ala Gly Lys Pro Thr Asp Lys Pro Asn Leu Val Cys Gly 
145                 150                 155                 160 


Pro Val Gln Ile Cys Trp His Lys Phe Ala Arg Tyr Trp Asp Val Glu 
                165                 170                 175     


Leu Arg Glu Ile Pro Met Arg Pro Gly Gln Leu Phe Met Asp Pro Lys 
            180                 185                 190         


Arg Met Ile Glu Ala Cys Asp Glu Asn Thr Ile Gly Val Val Pro Thr 
        195                 200                 205             


Phe Gly Val Thr Tyr Thr Gly Asn Tyr Glu Phe Pro Gln Pro Leu His 
    210                 215                 220                 


Asp Ala Leu Asp Lys Phe Gln Ala Asp Thr Gly Ile Asp Ile Asp Met 
225                 230                 235                 240 


His Ile Asp Ala Ala Ser Gly Gly Phe Leu Ala Pro Phe Val Ala Pro 
                245                 250                 255     


Asp Ile Val Trp Asp Phe Arg Leu Pro Arg Val Lys Ser Ile Ser Ala 
            260                 265                 270         


Ser Gly His Lys Phe Gly Leu Ala Pro Leu Gly Cys Gly Trp Val Ile 
        275                 280                 285             


Trp Arg Asp Glu Glu Ala Leu Pro Gln Glu Leu Val Phe Asn Val Asp 
    290                 295                 300                 


Tyr Leu Gly Gly Gln Ile Gly Thr Phe Ala Ile Asn Phe Ser Arg Pro 
305                 310                 315                 320 


Ala Gly Gln Val Ile Ala Gln Tyr Tyr Glu Phe Leu Arg Leu Gly Arg 
                325                 330                 335     


Glu Gly Tyr Thr Lys Val Gln Asn Ala Ser Tyr Gln Val Ala Ala Tyr 
            340                 345                 350         


Leu Ala Asp Glu Ile Ala Lys Leu Gly Pro Tyr Glu Phe Ile Cys Thr 
        355                 360                 365             


Gly Arg Pro Asp Glu Gly Ile Pro Ala Val Cys Phe Lys Leu Lys Asp 
    370                 375                 380                 


Gly Glu Asp Pro Gly Tyr Thr Leu Tyr Asp Leu Ser Glu Arg Leu Arg 
385                 390                 395                 400 


Leu Arg Gly Trp Gln Val Pro Ala Phe Thr Leu Gly Gly Glu Ala Thr 
                405                 410                 415     


Asp Ile Val Val Met Arg Ile Met Cys Arg Arg Gly Phe Glu Met Asp 
            420                 425                 430         


Phe Ala Glu Leu Leu Leu Glu Asp Tyr Lys Ala Ser Leu Lys Tyr Leu 
        435                 440                 445             


Ser Asp His Pro Lys Leu Gln Gly Ile Ala Gln Gln Asn Ser Phe Lys 
    450                 455                 460                 


Ala Thr 
465     


<210>  14
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S. thermosulfidooxidans GAD mutant E84Q

<400>  14

Met Lys Lys Ala Ser Glu Glu Val Ala Ile Asn Pro Leu Phe Ala Arg 
1               5                   10                  15      


Arg Gly Glu Glu Ser Val Pro Arg Tyr Arg Leu Ser Glu Glu Gly Leu 
            20                  25                  30          


Leu Pro Glu Thr Ala Tyr Gln Ile Val His Asp Glu Leu Thr Leu Asp 
        35                  40                  45              


Gly Ser Ala Arg Leu Asn Leu Ala Thr Phe Val Gly Thr Trp Met Glu 
    50                  55                  60                  


Pro Glu Ala Gln Lys Leu Tyr Val Glu Ala Ala Asn Lys Asn Ile Ile 
65                  70                  75                  80  


Asp Lys Asp Gln Tyr Pro Glu Thr Ala Ala Ile Glu Glu Arg Cys Leu 
                85                  90                  95      


Lys Ile Leu Ala Asn Leu Trp Asn Ala Pro Asp Pro Ala Asn Ser Ile 
            100                 105                 110         


Gly Val Ser Thr Thr Gly Ser Ser Glu Ala Cys Met Leu Gly Gly Leu 
        115                 120                 125             


Ala Leu Lys Arg Arg Trp Gln Leu Ser Arg Arg Gln Gln Gly Lys Ser 
    130                 135                 140                 


Thr Asp His Pro Asn Ile Val Phe Ser Ser Ala Val Gln Val Val Trp 
145                 150                 155                 160 


Glu Lys Phe Ala Asn Tyr Phe Glu Val Glu Pro Arg Tyr Val Asn Ile 
                165                 170                 175     


Thr Pro Glu His Pro Tyr Leu Thr Pro Glu Gly Val Ile Lys Ala Val 
            180                 185                 190         


Asp Glu Asn Thr Ile Gly Val Val Pro Ile Leu Gly Val Thr Tyr Thr 
        195                 200                 205             


Gly Ser Tyr Glu Pro Val Glu Ala Ile Ala Gln Ala Leu Asp Asp Leu 
    210                 215                 220                 


Glu Lys Arg Thr Gly Leu Ser Ile Pro Ile Val Asp Ala Ala Ser Gly 
225                 230                 235                 240 


Gly Phe Val Ala Pro Phe Leu Gln Pro Asp Leu Val Trp Asp Phe Arg 
                245                 250                 255     


Leu Pro Arg Val His Ser Ile Asn Thr Ser Gly His Lys Tyr Gly Leu 
            260                 265                 270         


Val Tyr Pro Gly Leu Gly Trp Val Leu Trp Arg Asp Lys Thr Leu Leu 
        275                 280                 285             


Pro Glu Glu Leu Ile Phe Asn Val Ser Tyr Leu Gly Gly Ser Met Pro 
    290                 295                 300                 


Thr Phe Gly Leu Asn Phe Ser Arg Pro Gly Ala Gln Val Leu Leu Gln 
305                 310                 315                 320 


Tyr Tyr Asn Phe Leu Arg Leu Gly Arg Gln Gly Tyr Tyr Thr Val Gln 
                325                 330                 335     


Lys Thr Cys Gln Asn Val Ala His Phe Leu Ala Gln Glu Ile Gly Ala 
            340                 345                 350         


Met Glu Pro Phe Glu Leu Val Thr Asp Gly Ser Asp Leu Pro Val Phe 
        355                 360                 365             


Ala Trp Arg Lys Arg Pro Glu Glu Asn Pro Leu Trp Ser Leu Glu Asp 
    370                 375                 380                 


Leu Ser Phe Val Leu Arg Glu Arg Gly Trp Gln Val Pro Ala Tyr Pro 
385                 390                 395                 400 


Leu Pro Pro Thr Met Gln Asp Val Thr Ile Met Arg Ile Val Val Arg 
                405                 410                 415     


Asn Ser Phe Ser Met Asp Met Ala Gln Leu Phe Leu Asp Asp Leu Asn 
            420                 425                 430         


Arg Ala Val Ala Tyr Leu Gln Gly Leu Asp His Pro Phe Pro Gln Ala 
        435                 440                 445             


Leu Arg Gln His Lys Pro Phe Ala His 
    450                 455         


<210>  15
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S. thermosulfidooxidans GAD mutant H457A

<400>  15

Met Lys Lys Ala Ser Glu Glu Val Ala Ile Asn Pro Leu Phe Ala Arg 
1               5                   10                  15      


Arg Gly Glu Glu Ser Val Pro Arg Tyr Arg Leu Ser Glu Glu Gly Leu 
            20                  25                  30          


Leu Pro Glu Thr Ala Tyr Gln Ile Val His Asp Glu Leu Thr Leu Asp 
        35                  40                  45              


Gly Ser Ala Arg Leu Asn Leu Ala Thr Phe Val Gly Thr Trp Met Glu 
    50                  55                  60                  


Pro Glu Ala Gln Lys Leu Tyr Val Glu Ala Ala Asn Lys Asn Ile Ile 
65                  70                  75                  80  


Asp Lys Asp Glu Tyr Pro Glu Thr Ala Ala Ile Glu Glu Arg Cys Leu 
                85                  90                  95      


Lys Ile Leu Ala Asn Leu Trp Asn Ala Pro Asp Pro Ala Asn Ser Ile 
            100                 105                 110         


Gly Val Ser Thr Thr Gly Ser Ser Glu Ala Cys Met Leu Gly Gly Leu 
        115                 120                 125             


Ala Leu Lys Arg Arg Trp Gln Leu Ser Arg Arg Gln Gln Gly Lys Ser 
    130                 135                 140                 


Thr Asp His Pro Asn Ile Val Phe Ser Ser Ala Val Gln Val Val Trp 
145                 150                 155                 160 


Glu Lys Phe Ala Asn Tyr Phe Glu Val Glu Pro Arg Tyr Val Asn Ile 
                165                 170                 175     


Thr Pro Glu His Pro Tyr Leu Thr Pro Glu Gly Val Ile Lys Ala Val 
            180                 185                 190         


Asp Glu Asn Thr Ile Gly Val Val Pro Ile Leu Gly Val Thr Tyr Thr 
        195                 200                 205             


Gly Ser Tyr Glu Pro Val Glu Ala Ile Ala Gln Ala Leu Asp Asp Leu 
    210                 215                 220                 


Glu Lys Arg Thr Gly Leu Ser Ile Pro Ile Val Asp Ala Ala Ser Gly 
225                 230                 235                 240 


Gly Phe Val Ala Pro Phe Leu Gln Pro Asp Leu Val Trp Asp Phe Arg 
                245                 250                 255     


Leu Pro Arg Val His Ser Ile Asn Thr Ser Gly His Lys Tyr Gly Leu 
            260                 265                 270         


Val Tyr Pro Gly Leu Gly Trp Val Leu Trp Arg Asp Lys Thr Leu Leu 
        275                 280                 285             


Pro Glu Glu Leu Ile Phe Asn Val Ser Tyr Leu Gly Gly Ser Met Pro 
    290                 295                 300                 


Thr Phe Gly Leu Asn Phe Ser Arg Pro Gly Ala Gln Val Leu Leu Gln 
305                 310                 315                 320 


Tyr Tyr Asn Phe Leu Arg Leu Gly Arg Gln Gly Tyr Tyr Thr Val Gln 
                325                 330                 335     


Lys Thr Cys Gln Asn Val Ala His Phe Leu Ala Gln Glu Ile Gly Ala 
            340                 345                 350         


Met Glu Pro Phe Glu Leu Val Thr Asp Gly Ser Asp Leu Pro Val Phe 
        355                 360                 365             


Ala Trp Arg Lys Arg Pro Glu Glu Asn Pro Leu Trp Ser Leu Glu Asp 
    370                 375                 380                 


Leu Ser Phe Val Leu Arg Glu Arg Gly Trp Gln Val Pro Ala Tyr Pro 
385                 390                 395                 400 


Leu Pro Pro Thr Met Gln Asp Val Thr Ile Met Arg Ile Val Val Arg 
                405                 410                 415     


Asn Ser Phe Ser Met Asp Met Ala Gln Leu Phe Leu Asp Asp Leu Asn 
            420                 425                 430         


Arg Ala Val Ala Tyr Leu Gln Gly Leu Asp His Pro Phe Pro Gln Ala 
        435                 440                 445             


Leu Arg Gln His Lys Pro Phe Ala Ala 
    450                 455         


<210>  16
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S. thermosulfidooxidans GAD mutant E84Q+H457A

<400>  16

Met Lys Lys Ala Ser Glu Glu Val Ala Ile Asn Pro Leu Phe Ala Arg 
1               5                   10                  15      


Arg Gly Glu Glu Ser Val Pro Arg Tyr Arg Leu Ser Glu Glu Gly Leu 
            20                  25                  30          


Leu Pro Glu Thr Ala Tyr Gln Ile Val His Asp Glu Leu Thr Leu Asp 
        35                  40                  45              


Gly Ser Ala Arg Leu Asn Leu Ala Thr Phe Val Gly Thr Trp Met Glu 
    50                  55                  60                  


Pro Glu Ala Gln Lys Leu Tyr Val Glu Ala Ala Asn Lys Asn Ile Ile 
65                  70                  75                  80  


Asp Lys Asp Gln Tyr Pro Glu Thr Ala Ala Ile Glu Glu Arg Cys Leu 
                85                  90                  95      


Lys Ile Leu Ala Asn Leu Trp Asn Ala Pro Asp Pro Ala Asn Ser Ile 
            100                 105                 110         


Gly Val Ser Thr Thr Gly Ser Ser Glu Ala Cys Met Leu Gly Gly Leu 
        115                 120                 125             


Ala Leu Lys Arg Arg Trp Gln Leu Ser Arg Arg Gln Gln Gly Lys Ser 
    130                 135                 140                 


Thr Asp His Pro Asn Ile Val Phe Ser Ser Ala Val Gln Val Val Trp 
145                 150                 155                 160 


Glu Lys Phe Ala Asn Tyr Phe Glu Val Glu Pro Arg Tyr Val Asn Ile 
                165                 170                 175     


Thr Pro Glu His Pro Tyr Leu Thr Pro Glu Gly Val Ile Lys Ala Val 
            180                 185                 190         


Asp Glu Asn Thr Ile Gly Val Val Pro Ile Leu Gly Val Thr Tyr Thr 
        195                 200                 205             


Gly Ser Tyr Glu Pro Val Glu Ala Ile Ala Gln Ala Leu Asp Asp Leu 
    210                 215                 220                 


Glu Lys Arg Thr Gly Leu Ser Ile Pro Ile Val Asp Ala Ala Ser Gly 
225                 230                 235                 240 


Gly Phe Val Ala Pro Phe Leu Gln Pro Asp Leu Val Trp Asp Phe Arg 
                245                 250                 255     


Leu Pro Arg Val His Ser Ile Asn Thr Ser Gly His Lys Tyr Gly Leu 
            260                 265                 270         


Val Tyr Pro Gly Leu Gly Trp Val Leu Trp Arg Asp Lys Thr Leu Leu 
        275                 280                 285             


Pro Glu Glu Leu Ile Phe Asn Val Ser Tyr Leu Gly Gly Ser Met Pro 
    290                 295                 300                 


Thr Phe Gly Leu Asn Phe Ser Arg Pro Gly Ala Gln Val Leu Leu Gln 
305                 310                 315                 320 


Tyr Tyr Asn Phe Leu Arg Leu Gly Arg Gln Gly Tyr Tyr Thr Val Gln 
                325                 330                 335     


Lys Thr Cys Gln Asn Val Ala His Phe Leu Ala Gln Glu Ile Gly Ala 
            340                 345                 350         


Met Glu Pro Phe Glu Leu Val Thr Asp Gly Ser Asp Leu Pro Val Phe 
        355                 360                 365             


Ala Trp Arg Lys Arg Pro Glu Glu Asn Pro Leu Trp Ser Leu Glu Asp 
    370                 375                 380                 


Leu Ser Phe Val Leu Arg Glu Arg Gly Trp Gln Val Pro Ala Tyr Pro 
385                 390                 395                 400 


Leu Pro Pro Thr Met Gln Asp Val Thr Ile Met Arg Ile Val Val Arg 
                405                 410                 415     


Asn Ser Phe Ser Met Asp Met Ala Gln Leu Phe Leu Asp Asp Leu Asn 
            420                 425                 430         


Arg Ala Val Ala Tyr Leu Gln Gly Leu Asp His Pro Phe Pro Gln Ala 
        435                 440                 445             


Leu Arg Gln His Lys Pro Phe Ala Ala 
    450                 455         


<210>  17
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B. megaterium GAD mutant E93Q

<400>  17

Met Pro Gln Trp His Pro His Arg Glu Gln Lys Asn Leu Pro Asp Glu 
1               5                   10                  15      


Phe Pro Val Asn Pro Leu Phe Ser Arg Gln Gly Glu Val Thr Ile Pro 
            20                  25                  30          


Arg Leu Arg Ile Ser Asp Gln Gly Met Leu Pro Glu Thr Ala Tyr Gln 
        35                  40                  45              


Ile Ile His Asp Glu Ile Ala Leu Asp Gly Asn Ala Arg Leu Asn Leu 
    50                  55                  60                  


Ala Thr Phe Val Thr Thr Trp Met Glu Pro Asp Ala Lys Arg Leu Tyr 
65                  70                  75                  80  


Gly Glu Ser Phe Asp Lys Asn Met Ile Asp Lys Asp Gln Tyr Pro Gln 
                85                  90                  95      


Thr Ala Ala Ile Glu Glu Arg Cys Val Arg Ile Leu Ala Asp Leu Trp 
            100                 105                 110         


Asn Ser Pro Asn Pro Asp Thr Thr Met Gly Val Ser Thr Thr Gly Ser 
        115                 120                 125             


Ser Glu Ala Cys Met Leu Gly Gly Leu Ala Leu Lys Arg Arg Trp Gln 
    130                 135                 140                 


Lys Leu Arg Lys Ser Lys Gly Leu Ser Thr Asp Arg Pro Asn Ile Val 
145                 150                 155                 160 


Phe Ser Ser Ser Val Gln Val Val Trp Glu Lys Phe Ala Asn Tyr Trp 
                165                 170                 175     


Asp Val Glu Pro Arg Tyr Val Asn Ile Asn Pro Asp His Pro Tyr Leu 
            180                 185                 190         


Asp Ala Glu Gly Val Ile Asn Ala Val Asp Glu Asn Thr Ile Gly Val 
        195                 200                 205             


Val Pro Ile Leu Gly Val Thr Tyr Thr Gly Val Tyr Glu Pro Ile Ala 
    210                 215                 220                 


Ala Ile Ala Lys Ala Leu Asp Glu Leu Gln Glu Lys Thr Gly Leu Asp 
225                 230                 235                 240 


Ile Pro Ile His Val Asp Ala Ala Ser Gly Gly Phe Ile Ala Pro Phe 
                245                 250                 255     


Leu Gln Pro Asp Leu Ile Trp Asp Phe Arg Leu Pro Arg Val Lys Ser 
            260                 265                 270         


Ile Asn Val Ser Gly His Lys Tyr Gly Leu Val Tyr Pro Gly Leu Gly 
        275                 280                 285             


Trp Val Ile Trp Arg Glu Lys Glu Asp Leu Pro Glu Asp Leu Ile Phe 
    290                 295                 300                 


Arg Val Ser Tyr Leu Gly Gly Asn Met Pro Thr Phe Ala Leu Asn Phe 
305                 310                 315                 320 


Ser Arg Pro Gly Ala Gln Val Leu Leu Gln Tyr Tyr Asn Phe Leu Arg 
                325                 330                 335     


Leu Gly Lys Asp Gly Tyr Tyr Ala Val Gln Lys Thr Ser Gln Glu Asn 
            340                 345                 350         


Ala Leu Phe Leu Ser Lys Glu Ile Gly Glu Met Glu Ala Phe Glu Ile 
        355                 360                 365             


Leu Ala Asp Gly Ser Asp Ile Pro Val Leu Ala Trp Lys Leu Lys Glu 
    370                 375                 380                 


Gly Tyr Thr Pro Asn Trp Thr Leu Tyr Asp Leu Ser Arg Gln Leu Arg 
385                 390                 395                 400 


Thr Tyr Gly Trp Gln Val Pro Ala Tyr Pro Leu Pro Ala Asp Met Glu 
                405                 410                 415     


Glu Ile Thr Ile Met Arg Ile Val Val Arg Asn Gly Phe Ser Arg Asp 
            420                 425                 430         


Leu Ala His Leu Phe Met Val Asn Phe Lys Gln Ala Val Glu Phe Leu 
        435                 440                 445             


Asn Ser Leu Asp Arg Pro Val Leu Lys Asp Thr Lys Tyr Asp Asn Gly 
    450                 455                 460                 


Phe His His 
465         


<210>  18
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B. megaterium GAD mutant H467A

<400>  18

Met Pro Gln Trp His Pro His Arg Glu Gln Lys Asn Leu Pro Asp Glu 
1               5                   10                  15      


Phe Pro Val Asn Pro Leu Phe Ser Arg Gln Gly Glu Val Thr Ile Pro 
            20                  25                  30          


Arg Leu Arg Ile Ser Asp Gln Gly Met Leu Pro Glu Thr Ala Tyr Gln 
        35                  40                  45              


Ile Ile His Asp Glu Ile Ala Leu Asp Gly Asn Ala Arg Leu Asn Leu 
    50                  55                  60                  


Ala Thr Phe Val Thr Thr Trp Met Glu Pro Asp Ala Lys Arg Leu Tyr 
65                  70                  75                  80  


Gly Glu Ser Phe Asp Lys Asn Met Ile Asp Lys Asp Glu Tyr Pro Gln 
                85                  90                  95      


Thr Ala Ala Ile Glu Glu Arg Cys Val Arg Ile Leu Ala Asp Leu Trp 
            100                 105                 110         


Asn Ser Pro Asn Pro Asp Thr Thr Met Gly Val Ser Thr Thr Gly Ser 
        115                 120                 125             


Ser Glu Ala Cys Met Leu Gly Gly Leu Ala Leu Lys Arg Arg Trp Gln 
    130                 135                 140                 


Lys Leu Arg Lys Ser Lys Gly Leu Ser Thr Asp Arg Pro Asn Ile Val 
145                 150                 155                 160 


Phe Ser Ser Ser Val Gln Val Val Trp Glu Lys Phe Ala Asn Tyr Trp 
                165                 170                 175     


Asp Val Glu Pro Arg Tyr Val Asn Ile Asn Pro Asp His Pro Tyr Leu 
            180                 185                 190         


Asp Ala Glu Gly Val Ile Asn Ala Val Asp Glu Asn Thr Ile Gly Val 
        195                 200                 205             


Val Pro Ile Leu Gly Val Thr Tyr Thr Gly Val Tyr Glu Pro Ile Ala 
    210                 215                 220                 


Ala Ile Ala Lys Ala Leu Asp Glu Leu Gln Glu Lys Thr Gly Leu Asp 
225                 230                 235                 240 


Ile Pro Ile His Val Asp Ala Ala Ser Gly Gly Phe Ile Ala Pro Phe 
                245                 250                 255     


Leu Gln Pro Asp Leu Ile Trp Asp Phe Arg Leu Pro Arg Val Lys Ser 
            260                 265                 270         


Ile Asn Val Ser Gly His Lys Tyr Gly Leu Val Tyr Pro Gly Leu Gly 
        275                 280                 285             


Trp Val Ile Trp Arg Glu Lys Glu Asp Leu Pro Glu Asp Leu Ile Phe 
    290                 295                 300                 


Arg Val Ser Tyr Leu Gly Gly Asn Met Pro Thr Phe Ala Leu Asn Phe 
305                 310                 315                 320 


Ser Arg Pro Gly Ala Gln Val Leu Leu Gln Tyr Tyr Asn Phe Leu Arg 
                325                 330                 335     


Leu Gly Lys Asp Gly Tyr Tyr Ala Val Gln Lys Thr Ser Gln Glu Asn 
            340                 345                 350         


Ala Leu Phe Leu Ser Lys Glu Ile Gly Glu Met Glu Ala Phe Glu Ile 
        355                 360                 365             


Leu Ala Asp Gly Ser Asp Ile Pro Val Leu Ala Trp Lys Leu Lys Glu 
    370                 375                 380                 


Gly Tyr Thr Pro Asn Trp Thr Leu Tyr Asp Leu Ser Arg Gln Leu Arg 
385                 390                 395                 400 


Thr Tyr Gly Trp Gln Val Pro Ala Tyr Pro Leu Pro Ala Asp Met Glu 
                405                 410                 415     


Glu Ile Thr Ile Met Arg Ile Val Val Arg Asn Gly Phe Ser Arg Asp 
            420                 425                 430         


Leu Ala His Leu Phe Met Val Asn Phe Lys Gln Ala Val Glu Phe Leu 
        435                 440                 445             


Asn Ser Leu Asp Arg Pro Val Leu Lys Asp Thr Lys Tyr Asp Asn Gly 
    450                 455                 460                 


Phe His Ala 
465         


<210>  19
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B. megaterium GAD mutant E93Q+H467A

<400>  19

Met Pro Gln Trp His Pro His Arg Glu Gln Lys Asn Leu Pro Asp Glu 
1               5                   10                  15      


Phe Pro Val Asn Pro Leu Phe Ser Arg Gln Gly Glu Val Thr Ile Pro 
            20                  25                  30          


Arg Leu Arg Ile Ser Asp Gln Gly Met Leu Pro Glu Thr Ala Tyr Gln 
        35                  40                  45              


Ile Ile His Asp Glu Ile Ala Leu Asp Gly Asn Ala Arg Leu Asn Leu 
    50                  55                  60                  


Ala Thr Phe Val Thr Thr Trp Met Glu Pro Asp Ala Lys Arg Leu Tyr 
65                  70                  75                  80  


Gly Glu Ser Phe Asp Lys Asn Met Ile Asp Lys Asp Gln Tyr Pro Gln 
                85                  90                  95      


Thr Ala Ala Ile Glu Glu Arg Cys Val Arg Ile Leu Ala Asp Leu Trp 
            100                 105                 110         


Asn Ser Pro Asn Pro Asp Thr Thr Met Gly Val Ser Thr Thr Gly Ser 
        115                 120                 125             


Ser Glu Ala Cys Met Leu Gly Gly Leu Ala Leu Lys Arg Arg Trp Gln 
    130                 135                 140                 


Lys Leu Arg Lys Ser Lys Gly Leu Ser Thr Asp Arg Pro Asn Ile Val 
145                 150                 155                 160 


Phe Ser Ser Ser Val Gln Val Val Trp Glu Lys Phe Ala Asn Tyr Trp 
                165                 170                 175     


Asp Val Glu Pro Arg Tyr Val Asn Ile Asn Pro Asp His Pro Tyr Leu 
            180                 185                 190         


Asp Ala Glu Gly Val Ile Asn Ala Val Asp Glu Asn Thr Ile Gly Val 
        195                 200                 205             


Val Pro Ile Leu Gly Val Thr Tyr Thr Gly Val Tyr Glu Pro Ile Ala 
    210                 215                 220                 


Ala Ile Ala Lys Ala Leu Asp Glu Leu Gln Glu Lys Thr Gly Leu Asp 
225                 230                 235                 240 


Ile Pro Ile His Val Asp Ala Ala Ser Gly Gly Phe Ile Ala Pro Phe 
                245                 250                 255     


Leu Gln Pro Asp Leu Ile Trp Asp Phe Arg Leu Pro Arg Val Lys Ser 
            260                 265                 270         


Ile Asn Val Ser Gly His Lys Tyr Gly Leu Val Tyr Pro Gly Leu Gly 
        275                 280                 285             


Trp Val Ile Trp Arg Glu Lys Glu Asp Leu Pro Glu Asp Leu Ile Phe 
    290                 295                 300                 


Arg Val Ser Tyr Leu Gly Gly Asn Met Pro Thr Phe Ala Leu Asn Phe 
305                 310                 315                 320 


Ser Arg Pro Gly Ala Gln Val Leu Leu Gln Tyr Tyr Asn Phe Leu Arg 
                325                 330                 335     


Leu Gly Lys Asp Gly Tyr Tyr Ala Val Gln Lys Thr Ser Gln Glu Asn 
            340                 345                 350         


Ala Leu Phe Leu Ser Lys Glu Ile Gly Glu Met Glu Ala Phe Glu Ile 
        355                 360                 365             


Leu Ala Asp Gly Ser Asp Ile Pro Val Leu Ala Trp Lys Leu Lys Glu 
    370                 375                 380                 


Gly Tyr Thr Pro Asn Trp Thr Leu Tyr Asp Leu Ser Arg Gln Leu Arg 
385                 390                 395                 400 


Thr Tyr Gly Trp Gln Val Pro Ala Tyr Pro Leu Pro Ala Asp Met Glu 
                405                 410                 415     


Glu Ile Thr Ile Met Arg Ile Val Val Arg Asn Gly Phe Ser Arg Asp 
            420                 425                 430         


Leu Ala His Leu Phe Met Val Asn Phe Lys Gln Ala Val Glu Phe Leu 
        435                 440                 445             


Asn Ser Leu Asp Arg Pro Val Leu Lys Asp Thr Lys Tyr Asp Asn Gly 
    450                 455                 460                 


Phe His Ala 
465         


<210>  20
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L. innocua GAD mutant E90Q

<400>  20

Met Leu Tyr Ser Glu Asn Asp Lys Arg Lys His Glu Ser Tyr Arg Ile 
1               5                   10                  15      


Pro Leu Phe Gly Ser Glu Glu Glu Ser Thr Ser Ile Pro Lys Tyr Val 
            20                  25                  30          


Leu Lys Lys Glu Pro Met Glu Pro Arg Ile Ala Tyr Gln Leu Val Lys 
        35                  40                  45              


Asp Gln Leu Met Asp Glu Gly Asn Ala Arg Gln Asn Leu Ala Thr Phe 
    50                  55                  60                  


Cys Gln Thr Tyr Met Glu Lys Glu Ala Glu Ile Leu Met Ala Glu Thr 
65                  70                  75                  80  


Leu Glu Lys Asn Ala Ile Asp Lys Ser Gln Tyr Pro Gln Thr Ala Glu 
                85                  90                  95      


Leu Glu Asn Arg Cys Val Asn Ile Leu Ala Asp Leu Trp Asn Ala Pro 
            100                 105                 110         


Lys Glu Met Ser Tyr Leu Gly Thr Ser Thr Val Gly Ser Ser Glu Ala 
        115                 120                 125             


Cys Met Leu Gly Gly Leu Ala Met Lys Phe Arg Trp Arg Asn Asn Ala 
    130                 135                 140                 


Glu Lys Arg Gly Leu Asp Ile Gln Ala Lys Arg Pro Asn Leu Ile Ile 
145                 150                 155                 160 


Ser Ser Gly Tyr Gln Val Cys Trp Glu Lys Phe Cys Val Tyr Trp Asp 
                165                 170                 175     


Val Asp Met Arg Val Val Pro Met Asp Lys Glu His Leu Ser Leu Asp 
            180                 185                 190         


Val Glu Lys Val Phe Glu Leu Val Asp Glu Tyr Thr Ile Gly Ile Val 
        195                 200                 205             


Gly Ile Leu Gly Ile Thr Tyr Thr Gly Lys Phe Asp Asp Ile Ala Leu 
    210                 215                 220                 


Leu Asp Glu Lys Val Glu Ala Tyr Asn Glu Ala Asn Glu His Gln Leu 
225                 230                 235                 240 


Val Ile His Ile Asp Gly Ala Ser Gly Ala Met Phe Thr Pro Phe Val 
                245                 250                 255     


Asn Pro Glu Leu Pro Trp Asp Phe Arg Leu Lys Asn Val Val Ser Ile 
            260                 265                 270         


Asn Thr Ser Gly His Lys Tyr Gly Leu Val Tyr Pro Gly Val Gly Trp 
        275                 280                 285             


Ile Leu Trp Lys Asp Lys Glu Tyr Leu Pro Lys Glu Leu Ile Phe Glu 
    290                 295                 300                 


Val Ser Tyr Leu Gly Gly Ser Met Pro Thr Met Ala Ile Asn Phe Ser 
305                 310                 315                 320 


Arg Ser Ala Ser Gln Ile Ile Gly Gln Tyr Tyr Asn Phe Leu Arg Tyr 
                325                 330                 335     


Gly Phe Glu Gly Tyr Arg Glu Ile His Glu Lys Thr Lys Lys Thr Ala 
            340                 345                 350         


Leu Tyr Leu Ser Lys Thr Val Glu Lys Ser Gly Tyr Phe Glu Ile Ile 
        355                 360                 365             


Asn Asp Gly Ser Asn Leu Pro Ile Val Cys Tyr Lys Leu Lys Asp Asp 
    370                 375                 380                 


Leu Asp Val Glu Trp Thr Leu Tyr Asp Leu Ala Asp Gln Leu Leu Met 
385                 390                 395                 400 


Lys Gly Trp Gln Val Pro Ala Tyr Pro Leu Pro Ala Asp Leu Ser Asp 
                405                 410                 415     


Thr Ile Ile Gln Arg Phe Val Cys Arg Ala Asp Leu Gly Tyr Asn Val 
            420                 425                 430         


Ala Glu Glu Phe Ala Ala Asp Phe Ala Asp Ala Leu His Asn Leu Glu 
        435                 440                 445             


His Ala Arg Val Leu Tyr His Asp Lys Glu Arg Asn Asp Ser Tyr Gly 
    450                 455                 460                 


Phe Thr His 
465         


<210>  21
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L. innocua GAD mutant H467A

<400>  21

Met Leu Tyr Ser Glu Asn Asp Lys Arg Lys His Glu Ser Tyr Arg Ile 
1               5                   10                  15      


Pro Leu Phe Gly Ser Glu Glu Glu Ser Thr Ser Ile Pro Lys Tyr Val 
            20                  25                  30          


Leu Lys Lys Glu Pro Met Glu Pro Arg Ile Ala Tyr Gln Leu Val Lys 
        35                  40                  45              


Asp Gln Leu Met Asp Glu Gly Asn Ala Arg Gln Asn Leu Ala Thr Phe 
    50                  55                  60                  


Cys Gln Thr Tyr Met Glu Lys Glu Ala Glu Ile Leu Met Ala Glu Thr 
65                  70                  75                  80  


Leu Glu Lys Asn Ala Ile Asp Lys Ser Glu Tyr Pro Gln Thr Ala Glu 
                85                  90                  95      


Leu Glu Asn Arg Cys Val Asn Ile Leu Ala Asp Leu Trp Asn Ala Pro 
            100                 105                 110         


Lys Glu Met Ser Tyr Leu Gly Thr Ser Thr Val Gly Ser Ser Glu Ala 
        115                 120                 125             


Cys Met Leu Gly Gly Leu Ala Met Lys Phe Arg Trp Arg Asn Asn Ala 
    130                 135                 140                 


Glu Lys Arg Gly Leu Asp Ile Gln Ala Lys Arg Pro Asn Leu Ile Ile 
145                 150                 155                 160 


Ser Ser Gly Tyr Gln Val Cys Trp Glu Lys Phe Cys Val Tyr Trp Asp 
                165                 170                 175     


Val Asp Met Arg Val Val Pro Met Asp Lys Glu His Leu Ser Leu Asp 
            180                 185                 190         


Val Glu Lys Val Phe Glu Leu Val Asp Glu Tyr Thr Ile Gly Ile Val 
        195                 200                 205             


Gly Ile Leu Gly Ile Thr Tyr Thr Gly Lys Phe Asp Asp Ile Ala Leu 
    210                 215                 220                 


Leu Asp Glu Lys Val Glu Ala Tyr Asn Glu Ala Asn Glu His Gln Leu 
225                 230                 235                 240 


Val Ile His Ile Asp Gly Ala Ser Gly Ala Met Phe Thr Pro Phe Val 
                245                 250                 255     


Asn Pro Glu Leu Pro Trp Asp Phe Arg Leu Lys Asn Val Val Ser Ile 
            260                 265                 270         


Asn Thr Ser Gly His Lys Tyr Gly Leu Val Tyr Pro Gly Val Gly Trp 
        275                 280                 285             


Ile Leu Trp Lys Asp Lys Glu Tyr Leu Pro Lys Glu Leu Ile Phe Glu 
    290                 295                 300                 


Val Ser Tyr Leu Gly Gly Ser Met Pro Thr Met Ala Ile Asn Phe Ser 
305                 310                 315                 320 


Arg Ser Ala Ser Gln Ile Ile Gly Gln Tyr Tyr Asn Phe Leu Arg Tyr 
                325                 330                 335     


Gly Phe Glu Gly Tyr Arg Glu Ile His Glu Lys Thr Lys Lys Thr Ala 
            340                 345                 350         


Leu Tyr Leu Ser Lys Thr Val Glu Lys Ser Gly Tyr Phe Glu Ile Ile 
        355                 360                 365             


Asn Asp Gly Ser Asn Leu Pro Ile Val Cys Tyr Lys Leu Lys Asp Asp 
    370                 375                 380                 


Leu Asp Val Glu Trp Thr Leu Tyr Asp Leu Ala Asp Gln Leu Leu Met 
385                 390                 395                 400 


Lys Gly Trp Gln Val Pro Ala Tyr Pro Leu Pro Ala Asp Leu Ser Asp 
                405                 410                 415     


Thr Ile Ile Gln Arg Phe Val Cys Arg Ala Asp Leu Gly Tyr Asn Val 
            420                 425                 430         


Ala Glu Glu Phe Ala Ala Asp Phe Ala Asp Ala Leu His Asn Leu Glu 
        435                 440                 445             


His Ala Arg Val Leu Tyr His Asp Lys Glu Arg Asn Asp Ser Tyr Gly 
    450                 455                 460                 


Phe Thr Ala 
465         


<210>  22
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L. innocua GAD mutant E90Q+H467A

<400>  22

Met Leu Tyr Ser Glu Asn Asp Lys Arg Lys His Glu Ser Tyr Arg Ile 
1               5                   10                  15      


Pro Leu Phe Gly Ser Glu Glu Glu Ser Thr Ser Ile Pro Lys Tyr Val 
            20                  25                  30          


Leu Lys Lys Glu Pro Met Glu Pro Arg Ile Ala Tyr Gln Leu Val Lys 
        35                  40                  45              


Asp Gln Leu Met Asp Glu Gly Asn Ala Arg Gln Asn Leu Ala Thr Phe 
    50                  55                  60                  


Cys Gln Thr Tyr Met Glu Lys Glu Ala Glu Ile Leu Met Ala Glu Thr 
65                  70                  75                  80  


Leu Glu Lys Asn Ala Ile Asp Lys Ser Gln Tyr Pro Gln Thr Ala Glu 
                85                  90                  95      


Leu Glu Asn Arg Cys Val Asn Ile Leu Ala Asp Leu Trp Asn Ala Pro 
            100                 105                 110         


Lys Glu Met Ser Tyr Leu Gly Thr Ser Thr Val Gly Ser Ser Glu Ala 
        115                 120                 125             


Cys Met Leu Gly Gly Leu Ala Met Lys Phe Arg Trp Arg Asn Asn Ala 
    130                 135                 140                 


Glu Lys Arg Gly Leu Asp Ile Gln Ala Lys Arg Pro Asn Leu Ile Ile 
145                 150                 155                 160 


Ser Ser Gly Tyr Gln Val Cys Trp Glu Lys Phe Cys Val Tyr Trp Asp 
                165                 170                 175     


Val Asp Met Arg Val Val Pro Met Asp Lys Glu His Leu Ser Leu Asp 
            180                 185                 190         


Val Glu Lys Val Phe Glu Leu Val Asp Glu Tyr Thr Ile Gly Ile Val 
        195                 200                 205             


Gly Ile Leu Gly Ile Thr Tyr Thr Gly Lys Phe Asp Asp Ile Ala Leu 
    210                 215                 220                 


Leu Asp Glu Lys Val Glu Ala Tyr Asn Glu Ala Asn Glu His Gln Leu 
225                 230                 235                 240 


Val Ile His Ile Asp Gly Ala Ser Gly Ala Met Phe Thr Pro Phe Val 
                245                 250                 255     


Asn Pro Glu Leu Pro Trp Asp Phe Arg Leu Lys Asn Val Val Ser Ile 
            260                 265                 270         


Asn Thr Ser Gly His Lys Tyr Gly Leu Val Tyr Pro Gly Val Gly Trp 
        275                 280                 285             


Ile Leu Trp Lys Asp Lys Glu Tyr Leu Pro Lys Glu Leu Ile Phe Glu 
    290                 295                 300                 


Val Ser Tyr Leu Gly Gly Ser Met Pro Thr Met Ala Ile Asn Phe Ser 
305                 310                 315                 320 


Arg Ser Ala Ser Gln Ile Ile Gly Gln Tyr Tyr Asn Phe Leu Arg Tyr 
                325                 330                 335     


Gly Phe Glu Gly Tyr Arg Glu Ile His Glu Lys Thr Lys Lys Thr Ala 
            340                 345                 350         


Leu Tyr Leu Ser Lys Thr Val Glu Lys Ser Gly Tyr Phe Glu Ile Ile 
        355                 360                 365             


Asn Asp Gly Ser Asn Leu Pro Ile Val Cys Tyr Lys Leu Lys Asp Asp 
    370                 375                 380                 


Leu Asp Val Glu Trp Thr Leu Tyr Asp Leu Ala Asp Gln Leu Leu Met 
385                 390                 395                 400 


Lys Gly Trp Gln Val Pro Ala Tyr Pro Leu Pro Ala Asp Leu Ser Asp 
                405                 410                 415     


Thr Ile Ile Gln Arg Phe Val Cys Arg Ala Asp Leu Gly Tyr Asn Val 
            420                 425                 430         


Ala Glu Glu Phe Ala Ala Asp Phe Ala Asp Ala Leu His Asn Leu Glu 
        435                 440                 445             


His Ala Arg Val Leu Tyr His Asp Lys Glu Arg Asn Asp Ser Tyr Gly 
    450                 455                 460                 


Phe Thr Ala 
465         


<210>  23
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L. monocytogenes GAD mutant E85Q

<400>  23

Met Phe Lys Thr Asn Val Glu Gln Asn Asn Val Pro Val Phe Gly Ser 
1               5                   10                  15      


Phe Glu Ser Gly Gln Asp Leu Pro Glu Lys Arg Met Asn Lys Glu Ser 
            20                  25                  30          


Val Asp Pro Arg Ile Ala Tyr Gln Leu Val Lys Asp Gln Leu Ile Asp 
        35                  40                  45              


Glu Gly Ser Ala Arg Gln Asn Leu Ala Thr Phe Cys Gln Thr Tyr Met 
    50                  55                  60                  


Glu Pro Glu Ala Glu Gln Ile Met Ala Glu Thr Met Glu Lys Asn Ala 
65                  70                  75                  80  


Ile Asp Lys Ser Gln Tyr Pro Gln Thr Ala Lys Leu Glu Ser Ser Cys 
                85                  90                  95      


Val Asn Met Leu Ala Asp Leu Trp Asn Val Asp Glu Ser Glu His Tyr 
            100                 105                 110         


Met Gly Thr Ser Thr Val Gly Ser Ser Glu Ala Cys Met Leu Gly Gly 
        115                 120                 125             


Met Ala Met Lys Phe Arg Trp Arg Ser Ala Ala Leu Lys Asn Gly Leu 
    130                 135                 140                 


Asp Ile His Ala Lys Lys Pro Ser Leu Val Ile Ser Ser Gly Tyr Gln 
145                 150                 155                 160 


Val Cys Trp Glu Lys Phe Cys Val Tyr Trp Asp Ile Glu Leu Arg Glu 
                165                 170                 175     


Val Pro Met Ser Glu Glu His Leu Ser Ile Asn Thr Asp Ile Ile Met 
            180                 185                 190         


Asp Tyr Val Asp Glu Tyr Thr Ile Gly Ile Val Gly Ile Leu Gly Ile 
        195                 200                 205             


Thr Tyr Thr Gly Lys Phe Asp Asp Ile Met Thr Leu Asn Asp Leu Val 
    210                 215                 220                 


Glu Asp Tyr Asn Asn Thr His Asp Asn Glu Val Val Ile His Val Asp 
225                 230                 235                 240 


Gly Ala Ser Gly Ala Met Phe Thr Pro Phe Val Glu Pro Gly Leu Glu 
                245                 250                 255     


Trp Asp Phe Arg Leu Pro Asn Val Val Ser Ile Asn Thr Ser Gly His 
            260                 265                 270         


Lys Tyr Gly Leu Val Tyr Pro Gly Val Gly Trp Ile Leu Trp Arg Asp 
        275                 280                 285             


Lys Glu Tyr Leu Pro Glu Glu Leu Val Phe Asp Val Ser Tyr Leu Gly 
    290                 295                 300                 


Gly His Met Pro Thr Met Ala Ile Asn Phe Ser Arg Ser Ala Ser Gln 
305                 310                 315                 320 


Ile Ile Gly Gln Tyr Tyr Asn Phe Leu Arg Phe Gly Tyr Glu Gly Tyr 
                325                 330                 335     


Arg Gln Ile His Met Arg Thr Arg Asp Gly Ala Leu Gln Leu Ser Gln 
            340                 345                 350         


Ala Val Ala Glu Thr Gly Leu Phe Glu Ile Tyr Asn Asp Gly Ala Asn 
        355                 360                 365             


Leu Pro Ile Val Cys Tyr Lys Leu Lys Asp Asp Ala Asn Val Ala Trp 
    370                 375                 380                 


Thr Leu Tyr Asp Leu Ala Asp Arg Leu Gln Met Lys Gly Trp Gln Val 
385                 390                 395                 400 


Pro Ala Tyr Pro Leu Pro Lys Glu Met Gly Asn Thr Ile Ile Gln Arg 
                405                 410                 415     


Tyr Val Cys Arg Gly Asp Leu Gly Gln Asn Met Val Thr Ala Phe Lys 
            420                 425                 430         


Asn Asp Leu Ser Glu Ser Ile Glu Glu Leu Asn Asn Ala His Ile Leu 
        435                 440                 445             


Tyr His Asp Val Asn Thr Ser Lys Thr His Gly Phe Thr His 
    450                 455                 460         


<210>  24
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L. monocytogenes GAD mutant H462A

<400>  24

Met Phe Lys Thr Asn Val Glu Gln Asn Asn Val Pro Val Phe Gly Ser 
1               5                   10                  15      


Phe Glu Ser Gly Gln Asp Leu Pro Glu Lys Arg Met Asn Lys Glu Ser 
            20                  25                  30          


Val Asp Pro Arg Ile Ala Tyr Gln Leu Val Lys Asp Gln Leu Ile Asp 
        35                  40                  45              


Glu Gly Ser Ala Arg Gln Asn Leu Ala Thr Phe Cys Gln Thr Tyr Met 
    50                  55                  60                  


Glu Pro Glu Ala Glu Gln Ile Met Ala Glu Thr Met Glu Lys Asn Ala 
65                  70                  75                  80  


Ile Asp Lys Ser Glu Tyr Pro Gln Thr Ala Lys Leu Glu Ser Ser Cys 
                85                  90                  95      


Val Asn Met Leu Ala Asp Leu Trp Asn Val Asp Glu Ser Glu His Tyr 
            100                 105                 110         


Met Gly Thr Ser Thr Val Gly Ser Ser Glu Ala Cys Met Leu Gly Gly 
        115                 120                 125             


Met Ala Met Lys Phe Arg Trp Arg Ser Ala Ala Leu Lys Asn Gly Leu 
    130                 135                 140                 


Asp Ile His Ala Lys Lys Pro Ser Leu Val Ile Ser Ser Gly Tyr Gln 
145                 150                 155                 160 


Val Cys Trp Glu Lys Phe Cys Val Tyr Trp Asp Ile Glu Leu Arg Glu 
                165                 170                 175     


Val Pro Met Ser Glu Glu His Leu Ser Ile Asn Thr Asp Ile Ile Met 
            180                 185                 190         


Asp Tyr Val Asp Glu Tyr Thr Ile Gly Ile Val Gly Ile Leu Gly Ile 
        195                 200                 205             


Thr Tyr Thr Gly Lys Phe Asp Asp Ile Met Thr Leu Asn Asp Leu Val 
    210                 215                 220                 


Glu Asp Tyr Asn Asn Thr His Asp Asn Glu Val Val Ile His Val Asp 
225                 230                 235                 240 


Gly Ala Ser Gly Ala Met Phe Thr Pro Phe Val Glu Pro Gly Leu Glu 
                245                 250                 255     


Trp Asp Phe Arg Leu Pro Asn Val Val Ser Ile Asn Thr Ser Gly His 
            260                 265                 270         


Lys Tyr Gly Leu Val Tyr Pro Gly Val Gly Trp Ile Leu Trp Arg Asp 
        275                 280                 285             


Lys Glu Tyr Leu Pro Glu Glu Leu Val Phe Asp Val Ser Tyr Leu Gly 
    290                 295                 300                 


Gly His Met Pro Thr Met Ala Ile Asn Phe Ser Arg Ser Ala Ser Gln 
305                 310                 315                 320 


Ile Ile Gly Gln Tyr Tyr Asn Phe Leu Arg Phe Gly Tyr Glu Gly Tyr 
                325                 330                 335     


Arg Gln Ile His Met Arg Thr Arg Asp Gly Ala Leu Gln Leu Ser Gln 
            340                 345                 350         


Ala Val Ala Glu Thr Gly Leu Phe Glu Ile Tyr Asn Asp Gly Ala Asn 
        355                 360                 365             


Leu Pro Ile Val Cys Tyr Lys Leu Lys Asp Asp Ala Asn Val Ala Trp 
    370                 375                 380                 


Thr Leu Tyr Asp Leu Ala Asp Arg Leu Gln Met Lys Gly Trp Gln Val 
385                 390                 395                 400 


Pro Ala Tyr Pro Leu Pro Lys Glu Met Gly Asn Thr Ile Ile Gln Arg 
                405                 410                 415     


Tyr Val Cys Arg Gly Asp Leu Gly Gln Asn Met Val Thr Ala Phe Lys 
            420                 425                 430         


Asn Asp Leu Ser Glu Ser Ile Glu Glu Leu Asn Asn Ala His Ile Leu 
        435                 440                 445             


Tyr His Asp Val Asn Thr Ser Lys Thr His Gly Phe Thr Ala 
    450                 455                 460         


<210>  25
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L. monocytogenes GAD mutant E85Q+H462A

<400>  25

Met Phe Lys Thr Asn Val Glu Gln Asn Asn Val Pro Val Phe Gly Ser 
1               5                   10                  15      


Phe Glu Ser Gly Gln Asp Leu Pro Glu Lys Arg Met Asn Lys Glu Ser 
            20                  25                  30          


Val Asp Pro Arg Ile Ala Tyr Gln Leu Val Lys Asp Gln Leu Ile Asp 
        35                  40                  45              


Glu Gly Ser Ala Arg Gln Asn Leu Ala Thr Phe Cys Gln Thr Tyr Met 
    50                  55                  60                  


Glu Pro Glu Ala Glu Gln Ile Met Ala Glu Thr Met Glu Lys Asn Ala 
65                  70                  75                  80  


Ile Asp Lys Ser Gln Tyr Pro Gln Thr Ala Lys Leu Glu Ser Ser Cys 
                85                  90                  95      


Val Asn Met Leu Ala Asp Leu Trp Asn Val Asp Glu Ser Glu His Tyr 
            100                 105                 110         


Met Gly Thr Ser Thr Val Gly Ser Ser Glu Ala Cys Met Leu Gly Gly 
        115                 120                 125             


Met Ala Met Lys Phe Arg Trp Arg Ser Ala Ala Leu Lys Asn Gly Leu 
    130                 135                 140                 


Asp Ile His Ala Lys Lys Pro Ser Leu Val Ile Ser Ser Gly Tyr Gln 
145                 150                 155                 160 


Val Cys Trp Glu Lys Phe Cys Val Tyr Trp Asp Ile Glu Leu Arg Glu 
                165                 170                 175     


Val Pro Met Ser Glu Glu His Leu Ser Ile Asn Thr Asp Ile Ile Met 
            180                 185                 190         


Asp Tyr Val Asp Glu Tyr Thr Ile Gly Ile Val Gly Ile Leu Gly Ile 
        195                 200                 205             


Thr Tyr Thr Gly Lys Phe Asp Asp Ile Met Thr Leu Asn Asp Leu Val 
    210                 215                 220                 


Glu Asp Tyr Asn Asn Thr His Asp Asn Glu Val Val Ile His Val Asp 
225                 230                 235                 240 


Gly Ala Ser Gly Ala Met Phe Thr Pro Phe Val Glu Pro Gly Leu Glu 
                245                 250                 255     


Trp Asp Phe Arg Leu Pro Asn Val Val Ser Ile Asn Thr Ser Gly His 
            260                 265                 270         


Lys Tyr Gly Leu Val Tyr Pro Gly Val Gly Trp Ile Leu Trp Arg Asp 
        275                 280                 285             


Lys Glu Tyr Leu Pro Glu Glu Leu Val Phe Asp Val Ser Tyr Leu Gly 
    290                 295                 300                 


Gly His Met Pro Thr Met Ala Ile Asn Phe Ser Arg Ser Ala Ser Gln 
305                 310                 315                 320 


Ile Ile Gly Gln Tyr Tyr Asn Phe Leu Arg Phe Gly Tyr Glu Gly Tyr 
                325                 330                 335     


Arg Gln Ile His Met Arg Thr Arg Asp Gly Ala Leu Gln Leu Ser Gln 
            340                 345                 350         


Ala Val Ala Glu Thr Gly Leu Phe Glu Ile Tyr Asn Asp Gly Ala Asn 
        355                 360                 365             


Leu Pro Ile Val Cys Tyr Lys Leu Lys Asp Asp Ala Asn Val Ala Trp 
    370                 375                 380                 


Thr Leu Tyr Asp Leu Ala Asp Arg Leu Gln Met Lys Gly Trp Gln Val 
385                 390                 395                 400 


Pro Ala Tyr Pro Leu Pro Lys Glu Met Gly Asn Thr Ile Ile Gln Arg 
                405                 410                 415     


Tyr Val Cys Arg Gly Asp Leu Gly Gln Asn Met Val Thr Ala Phe Lys 
            420                 425                 430         


Asn Asp Leu Ser Glu Ser Ile Glu Glu Leu Asn Asn Ala His Ile Leu 
        435                 440                 445             


Tyr His Asp Val Asn Thr Ser Lys Thr His Gly Phe Thr Ala 
    450                 455                 460         


<210>  26
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S. flexneri GAD mutant E89Q

<400>  26

Met Asp Gln Lys Leu Leu Thr Asp Phe Arg Ser Glu Leu Leu Asp Ser 
1               5                   10                  15      


Arg Phe Gly Ala Lys Ala Ile Ser Thr Ile Ala Glu Ser Lys Arg Phe 
            20                  25                  30          


Pro Leu His Glu Met Arg Asp Asp Val Ala Phe Gln Ile Ile Asn Asp 
        35                  40                  45              


Glu Leu Tyr Leu Asp Gly Asn Ala Arg Gln Asn Leu Ala Thr Phe Cys 
    50                  55                  60                  


Gln Thr Trp Asp Asp Glu Asn Val His Lys Leu Met Asp Leu Ser Ile 
65                  70                  75                  80  


Asn Lys Asn Trp Ile Asp Lys Glu Gln Tyr Pro Gln Ser Ala Ala Ile 
                85                  90                  95      


Asp Leu Arg Cys Val Asn Met Val Ala Asp Leu Trp His Ala Pro Ala 
            100                 105                 110         


Pro Lys Asn Gly Gln Ala Val Gly Thr Asn Thr Ile Gly Ser Ser Glu 
        115                 120                 125             


Ala Cys Met Leu Gly Gly Met Ala Met Lys Trp Arg Trp Arg Lys Arg 
    130                 135                 140                 


Met Glu Ala Ala Gly Lys Pro Thr Asp Lys Pro Asn Leu Val Cys Gly 
145                 150                 155                 160 


Pro Val Gln Ile Cys Trp His Lys Phe Ala Arg Tyr Trp Asp Val Glu 
                165                 170                 175     


Leu Arg Glu Ile Pro Met Arg Pro Gly Gln Leu Phe Met Asp Pro Lys 
            180                 185                 190         


Arg Met Ile Glu Ala Cys Asp Glu Asn Thr Ile Gly Val Val Pro Thr 
        195                 200                 205             


Phe Gly Val Thr Tyr Thr Gly Asn Tyr Glu Phe Pro Gln Pro Leu His 
    210                 215                 220                 


Asp Ala Leu Asp Lys Phe Gln Ala Asp Thr Gly Ile Asp Ile Asp Met 
225                 230                 235                 240 


His Ile Asp Ala Ala Ser Gly Gly Phe Leu Ala Pro Phe Val Ala Pro 
                245                 250                 255     


Asp Ile Val Trp Asp Phe Arg Leu Pro Arg Val Lys Ser Ile Ser Ala 
            260                 265                 270         


Ser Gly His Lys Phe Gly Leu Ala Pro Leu Gly Cys Gly Trp Val Ile 
        275                 280                 285             


Trp Arg Asp Glu Glu Ala Leu Pro Gln Glu Leu Val Phe Asn Val Asp 
    290                 295                 300                 


Tyr Leu Gly Gly Gln Ile Gly Thr Phe Ala Ile Asn Phe Ser Arg Pro 
305                 310                 315                 320 


Ala Gly Gln Val Ile Ala Gln Tyr Tyr Glu Phe Leu Arg Leu Gly Arg 
                325                 330                 335     


Glu Gly Tyr Thr Lys Val Gln Asn Ala Ser Tyr Gln Val Ala Ala Tyr 
            340                 345                 350         


Leu Ala Asp Glu Ile Ala Lys Gln Gly Pro Tyr Glu Phe Ile Cys Thr 
        355                 360                 365             


Gly Arg Pro Asp Glu Gly Ile Pro Ala Val Cys Phe Lys Leu Lys Asp 
    370                 375                 380                 


Gly Glu Asp Pro Gly Tyr Thr Leu Tyr Asp Leu Ser Glu Arg Leu Arg 
385                 390                 395                 400 


Leu Arg Gly Trp Gln Val Pro Ala Phe Thr Leu Gly Gly Glu Ala Thr 
                405                 410                 415     


Asp Ile Val Val Met Arg Ile Met Cys Arg Arg Gly Phe Glu Met Asp 
            420                 425                 430         


Phe Ala Glu Leu Leu Leu Glu Asp Tyr Lys Ala Ser Leu Lys Tyr Leu 
        435                 440                 445             


Ser Asp His Pro Lys Leu Gln Gly Ile Ala Gln Gln Asn Ser Phe Lys 
    450                 455                 460                 


His Thr 
465     


<210>  27
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S. flexneri GAD mutant H465A

<400>  27

Met Asp Gln Lys Leu Leu Thr Asp Phe Arg Ser Glu Leu Leu Asp Ser 
1               5                   10                  15      


Arg Phe Gly Ala Lys Ala Ile Ser Thr Ile Ala Glu Ser Lys Arg Phe 
            20                  25                  30          


Pro Leu His Glu Met Arg Asp Asp Val Ala Phe Gln Ile Ile Asn Asp 
        35                  40                  45              


Glu Leu Tyr Leu Asp Gly Asn Ala Arg Gln Asn Leu Ala Thr Phe Cys 
    50                  55                  60                  


Gln Thr Trp Asp Asp Glu Asn Val His Lys Leu Met Asp Leu Ser Ile 
65                  70                  75                  80  


Asn Lys Asn Trp Ile Asp Lys Glu Glu Tyr Pro Gln Ser Ala Ala Ile 
                85                  90                  95      


Asp Leu Arg Cys Val Asn Met Val Ala Asp Leu Trp His Ala Pro Ala 
            100                 105                 110         


Pro Lys Asn Gly Gln Ala Val Gly Thr Asn Thr Ile Gly Ser Ser Glu 
        115                 120                 125             


Ala Cys Met Leu Gly Gly Met Ala Met Lys Trp Arg Trp Arg Lys Arg 
    130                 135                 140                 


Met Glu Ala Ala Gly Lys Pro Thr Asp Lys Pro Asn Leu Val Cys Gly 
145                 150                 155                 160 


Pro Val Gln Ile Cys Trp His Lys Phe Ala Arg Tyr Trp Asp Val Glu 
                165                 170                 175     


Leu Arg Glu Ile Pro Met Arg Pro Gly Gln Leu Phe Met Asp Pro Lys 
            180                 185                 190         


Arg Met Ile Glu Ala Cys Asp Glu Asn Thr Ile Gly Val Val Pro Thr 
        195                 200                 205             


Phe Gly Val Thr Tyr Thr Gly Asn Tyr Glu Phe Pro Gln Pro Leu His 
    210                 215                 220                 


Asp Ala Leu Asp Lys Phe Gln Ala Asp Thr Gly Ile Asp Ile Asp Met 
225                 230                 235                 240 


His Ile Asp Ala Ala Ser Gly Gly Phe Leu Ala Pro Phe Val Ala Pro 
                245                 250                 255     


Asp Ile Val Trp Asp Phe Arg Leu Pro Arg Val Lys Ser Ile Ser Ala 
            260                 265                 270         


Ser Gly His Lys Phe Gly Leu Ala Pro Leu Gly Cys Gly Trp Val Ile 
        275                 280                 285             


Trp Arg Asp Glu Glu Ala Leu Pro Gln Glu Leu Val Phe Asn Val Asp 
    290                 295                 300                 


Tyr Leu Gly Gly Gln Ile Gly Thr Phe Ala Ile Asn Phe Ser Arg Pro 
305                 310                 315                 320 


Ala Gly Gln Val Ile Ala Gln Tyr Tyr Glu Phe Leu Arg Leu Gly Arg 
                325                 330                 335     


Glu Gly Tyr Thr Lys Val Gln Asn Ala Ser Tyr Gln Val Ala Ala Tyr 
            340                 345                 350         


Leu Ala Asp Glu Ile Ala Lys Gln Gly Pro Tyr Glu Phe Ile Cys Thr 
        355                 360                 365             


Gly Arg Pro Asp Glu Gly Ile Pro Ala Val Cys Phe Lys Leu Lys Asp 
    370                 375                 380                 


Gly Glu Asp Pro Gly Tyr Thr Leu Tyr Asp Leu Ser Glu Arg Leu Arg 
385                 390                 395                 400 


Leu Arg Gly Trp Gln Val Pro Ala Phe Thr Leu Gly Gly Glu Ala Thr 
                405                 410                 415     


Asp Ile Val Val Met Arg Ile Met Cys Arg Arg Gly Phe Glu Met Asp 
            420                 425                 430         


Phe Ala Glu Leu Leu Leu Glu Asp Tyr Lys Ala Ser Leu Lys Tyr Leu 
        435                 440                 445             


Ser Asp His Pro Lys Leu Gln Gly Ile Ala Gln Gln Asn Ser Phe Lys 
    450                 455                 460                 


Ala Thr 
465     


<210>  28
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S. flexneri GAD mutant E89Q+H465A

<400>  28

Met Asp Gln Lys Leu Leu Thr Asp Phe Arg Ser Glu Leu Leu Asp Ser 
1               5                   10                  15      


Arg Phe Gly Ala Lys Ala Ile Ser Thr Ile Ala Glu Ser Lys Arg Phe 
            20                  25                  30          


Pro Leu His Glu Met Arg Asp Asp Val Ala Phe Gln Ile Ile Asn Asp 
        35                  40                  45              


Glu Leu Tyr Leu Asp Gly Asn Ala Arg Gln Asn Leu Ala Thr Phe Cys 
    50                  55                  60                  


Gln Thr Trp Asp Asp Glu Asn Val His Lys Leu Met Asp Leu Ser Ile 
65                  70                  75                  80  


Asn Lys Asn Trp Ile Asp Lys Glu Gln Tyr Pro Gln Ser Ala Ala Ile 
                85                  90                  95      


Asp Leu Arg Cys Val Asn Met Val Ala Asp Leu Trp His Ala Pro Ala 
            100                 105                 110         


Pro Lys Asn Gly Gln Ala Val Gly Thr Asn Thr Ile Gly Ser Ser Glu 
        115                 120                 125             


Ala Cys Met Leu Gly Gly Met Ala Met Lys Trp Arg Trp Arg Lys Arg 
    130                 135                 140                 


Met Glu Ala Ala Gly Lys Pro Thr Asp Lys Pro Asn Leu Val Cys Gly 
145                 150                 155                 160 


Pro Val Gln Ile Cys Trp His Lys Phe Ala Arg Tyr Trp Asp Val Glu 
                165                 170                 175     


Leu Arg Glu Ile Pro Met Arg Pro Gly Gln Leu Phe Met Asp Pro Lys 
            180                 185                 190         


Arg Met Ile Glu Ala Cys Asp Glu Asn Thr Ile Gly Val Val Pro Thr 
        195                 200                 205             


Phe Gly Val Thr Tyr Thr Gly Asn Tyr Glu Phe Pro Gln Pro Leu His 
    210                 215                 220                 


Asp Ala Leu Asp Lys Phe Gln Ala Asp Thr Gly Ile Asp Ile Asp Met 
225                 230                 235                 240 


His Ile Asp Ala Ala Ser Gly Gly Phe Leu Ala Pro Phe Val Ala Pro 
                245                 250                 255     


Asp Ile Val Trp Asp Phe Arg Leu Pro Arg Val Lys Ser Ile Ser Ala 
            260                 265                 270         


Ser Gly His Lys Phe Gly Leu Ala Pro Leu Gly Cys Gly Trp Val Ile 
        275                 280                 285             


Trp Arg Asp Glu Glu Ala Leu Pro Gln Glu Leu Val Phe Asn Val Asp 
    290                 295                 300                 


Tyr Leu Gly Gly Gln Ile Gly Thr Phe Ala Ile Asn Phe Ser Arg Pro 
305                 310                 315                 320 


Ala Gly Gln Val Ile Ala Gln Tyr Tyr Glu Phe Leu Arg Leu Gly Arg 
                325                 330                 335     


Glu Gly Tyr Thr Lys Val Gln Asn Ala Ser Tyr Gln Val Ala Ala Tyr 
            340                 345                 350         


Leu Ala Asp Glu Ile Ala Lys Gln Gly Pro Tyr Glu Phe Ile Cys Thr 
        355                 360                 365             


Gly Arg Pro Asp Glu Gly Ile Pro Ala Val Cys Phe Lys Leu Lys Asp 
    370                 375                 380                 


Gly Glu Asp Pro Gly Tyr Thr Leu Tyr Asp Leu Ser Glu Arg Leu Arg 
385                 390                 395                 400 


Leu Arg Gly Trp Gln Val Pro Ala Phe Thr Leu Gly Gly Glu Ala Thr 
                405                 410                 415     


Asp Ile Val Val Met Arg Ile Met Cys Arg Arg Gly Phe Glu Met Asp 
            420                 425                 430         


Phe Ala Glu Leu Leu Leu Glu Asp Tyr Lys Ala Ser Leu Lys Tyr Leu 
        435                 440                 445             


Ser Asp His Pro Lys Leu Gln Gly Ile Ala Gln Gln Asn Ser Phe Lys 
    450                 455                 460                 


Ala Thr 
465     


<210>  29
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L. lactis subsp. lactis GAD mutant E89Q

<400>  29

Met Leu Tyr Gly Lys Glu Asn Arg Asp Glu Ala Glu Phe Leu Glu Pro 
1               5                   10                  15      


Ile Phe Gly Ser Glu Ser Glu Gln Val Asp Leu Pro Lys Tyr Lys Leu 
            20                  25                  30          


Ala Gln Gln Ser Ile Glu Pro Arg Val Ala Tyr Gln Leu Val Gln Asp 
        35                  40                  45              


Glu Met Leu Asp Glu Gly Asn Ala Arg Leu Asn Leu Ala Thr Phe Cys 
    50                  55                  60                  


Gln Thr Tyr Met Glu Pro Glu Ala Val Lys Leu Met Ser Gln Thr Leu 
65                  70                  75                  80  


Glu Lys Asn Ala Ile Asp Lys Ser Gln Tyr Pro Arg Thr Thr Glu Ile 
                85                  90                  95      


Glu Asn Arg Cys Val Asn Met Ile Ala Asp Leu Trp Asn Ala Ser Glu 
            100                 105                 110         


Lys Glu Lys Phe Met Gly Thr Ser Thr Ile Gly Ser Ser Glu Ala Cys 
        115                 120                 125             


Met Leu Gly Gly Met Ala Met Lys Phe Ser Trp Arg Lys Arg Ala Glu 
    130                 135                 140                 


Lys Leu Gly Leu Asp Ile Asn Ala Lys Lys Pro Asn Leu Val Ile Ser 
145                 150                 155                 160 


Ser Gly Tyr Gln Val Cys Trp Glu Lys Phe Cys Ile Tyr Trp Asp Ile 
                165                 170                 175     


Glu Met Arg Glu Val Pro Met Asp Lys Glu His Met Ser Ile Asn Leu 
            180                 185                 190         


Asp Lys Val Met Asp Tyr Val Asp Glu Tyr Thr Ile Gly Val Val Gly 
        195                 200                 205             


Ile Met Gly Ile Thr Tyr Thr Gly Arg Tyr Asp Asp Ile Lys Ala Leu 
    210                 215                 220                 


Asp Asn Leu Ile Glu Glu Tyr Asn Lys Gln Thr Asp Tyr Lys Val Tyr 
225                 230                 235                 240 


Ile His Val Asp Ala Ala Ser Gly Gly Leu Tyr Ala Pro Phe Val Glu 
                245                 250                 255     


Pro Glu Leu Glu Trp Asp Phe Arg Leu Lys Asn Val Ile Ser Ile Asn 
            260                 265                 270         


Thr Ser Gly His Lys Tyr Gly Leu Val Tyr Pro Gly Val Gly Trp Val 
        275                 280                 285             


Leu Trp Arg Asp Lys Lys Tyr Leu Pro Glu Glu Leu Ile Phe Lys Val 
    290                 295                 300                 


Ser Tyr Leu Gly Gly Glu Leu Pro Thr Met Ala Ile Asn Phe Ser His 
305                 310                 315                 320 


Ser Ala Ser Gln Leu Ile Gly Gln Tyr Tyr Asn Phe Val Arg Tyr Gly 
                325                 330                 335     


Phe Asp Gly Tyr Lys Ala Ile His Glu Arg Thr His Lys Val Ala Met 
            340                 345                 350         


Phe Leu Ala Lys Glu Ile Glu Lys Thr Gly Met Phe Glu Ile Met Asn 
        355                 360                 365             


Asp Gly Ser Gln Leu Pro Ile Val Cys Tyr Lys Leu Lys Glu Asp Ser 
    370                 375                 380                 


Asn Arg Gly Trp Asn Leu Tyr Asp Leu Ala Asp Arg Leu Leu Met Lys 
385                 390                 395                 400 


Gly Trp Gln Val Pro Ala Tyr Pro Leu Pro Lys Asn Leu Glu Asn Glu 
                405                 410                 415     


Ile Ile Gln Arg Leu Val Ile Arg Ala Asp Phe Gly Met Asn Met Ala 
            420                 425                 430         


Phe Asn Tyr Val Gln Asp Met Gln Glu Ala Ile Glu Ala Leu Asn Lys 
        435                 440                 445             


Ala His Ile Leu Tyr His Glu Glu Pro Glu Asn Lys Thr Tyr Gly Phe 
    450                 455                 460                 


Thr His 
465     


<210>  30
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L. lactis subsp. lactis GAD mutant H466A

<400>  30

Met Leu Tyr Gly Lys Glu Asn Arg Asp Glu Ala Glu Phe Leu Glu Pro 
1               5                   10                  15      


Ile Phe Gly Ser Glu Ser Glu Gln Val Asp Leu Pro Lys Tyr Lys Leu 
            20                  25                  30          


Ala Gln Gln Ser Ile Glu Pro Arg Val Ala Tyr Gln Leu Val Gln Asp 
        35                  40                  45              


Glu Met Leu Asp Glu Gly Asn Ala Arg Leu Asn Leu Ala Thr Phe Cys 
    50                  55                  60                  


Gln Thr Tyr Met Glu Pro Glu Ala Val Lys Leu Met Ser Gln Thr Leu 
65                  70                  75                  80  


Glu Lys Asn Ala Ile Asp Lys Ser Glu Tyr Pro Arg Thr Thr Glu Ile 
                85                  90                  95      


Glu Asn Arg Cys Val Asn Met Ile Ala Asp Leu Trp Asn Ala Ser Glu 
            100                 105                 110         


Lys Glu Lys Phe Met Gly Thr Ser Thr Ile Gly Ser Ser Glu Ala Cys 
        115                 120                 125             


Met Leu Gly Gly Met Ala Met Lys Phe Ser Trp Arg Lys Arg Ala Glu 
    130                 135                 140                 


Lys Leu Gly Leu Asp Ile Asn Ala Lys Lys Pro Asn Leu Val Ile Ser 
145                 150                 155                 160 


Ser Gly Tyr Gln Val Cys Trp Glu Lys Phe Cys Ile Tyr Trp Asp Ile 
                165                 170                 175     


Glu Met Arg Glu Val Pro Met Asp Lys Glu His Met Ser Ile Asn Leu 
            180                 185                 190         


Asp Lys Val Met Asp Tyr Val Asp Glu Tyr Thr Ile Gly Val Val Gly 
        195                 200                 205             


Ile Met Gly Ile Thr Tyr Thr Gly Arg Tyr Asp Asp Ile Lys Ala Leu 
    210                 215                 220                 


Asp Asn Leu Ile Glu Glu Tyr Asn Lys Gln Thr Asp Tyr Lys Val Tyr 
225                 230                 235                 240 


Ile His Val Asp Ala Ala Ser Gly Gly Leu Tyr Ala Pro Phe Val Glu 
                245                 250                 255     


Pro Glu Leu Glu Trp Asp Phe Arg Leu Lys Asn Val Ile Ser Ile Asn 
            260                 265                 270         


Thr Ser Gly His Lys Tyr Gly Leu Val Tyr Pro Gly Val Gly Trp Val 
        275                 280                 285             


Leu Trp Arg Asp Lys Lys Tyr Leu Pro Glu Glu Leu Ile Phe Lys Val 
    290                 295                 300                 


Ser Tyr Leu Gly Gly Glu Leu Pro Thr Met Ala Ile Asn Phe Ser His 
305                 310                 315                 320 


Ser Ala Ser Gln Leu Ile Gly Gln Tyr Tyr Asn Phe Val Arg Tyr Gly 
                325                 330                 335     


Phe Asp Gly Tyr Lys Ala Ile His Glu Arg Thr His Lys Val Ala Met 
            340                 345                 350         


Phe Leu Ala Lys Glu Ile Glu Lys Thr Gly Met Phe Glu Ile Met Asn 
        355                 360                 365             


Asp Gly Ser Gln Leu Pro Ile Val Cys Tyr Lys Leu Lys Glu Asp Ser 
    370                 375                 380                 


Asn Arg Gly Trp Asn Leu Tyr Asp Leu Ala Asp Arg Leu Leu Met Lys 
385                 390                 395                 400 


Gly Trp Gln Val Pro Ala Tyr Pro Leu Pro Lys Asn Leu Glu Asn Glu 
                405                 410                 415     


Ile Ile Gln Arg Leu Val Ile Arg Ala Asp Phe Gly Met Asn Met Ala 
            420                 425                 430         


Phe Asn Tyr Val Gln Asp Met Gln Glu Ala Ile Glu Ala Leu Asn Lys 
        435                 440                 445             


Ala His Ile Leu Tyr His Glu Glu Pro Glu Asn Lys Thr Tyr Gly Phe 
    450                 455                 460                 


Thr Ala 
465     


<210>  31
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L. lactis subsp. lactis GAD mutant E89Q+H466A

<400>  31

Met Leu Tyr Gly Lys Glu Asn Arg Asp Glu Ala Glu Phe Leu Glu Pro 
1               5                   10                  15      


Ile Phe Gly Ser Glu Ser Glu Gln Val Asp Leu Pro Lys Tyr Lys Leu 
            20                  25                  30          


Ala Gln Gln Ser Ile Glu Pro Arg Val Ala Tyr Gln Leu Val Gln Asp 
        35                  40                  45              


Glu Met Leu Asp Glu Gly Asn Ala Arg Leu Asn Leu Ala Thr Phe Cys 
    50                  55                  60                  


Gln Thr Tyr Met Glu Pro Glu Ala Val Lys Leu Met Ser Gln Thr Leu 
65                  70                  75                  80  


Glu Lys Asn Ala Ile Asp Lys Ser Gln Tyr Pro Arg Thr Thr Glu Ile 
                85                  90                  95      


Glu Asn Arg Cys Val Asn Met Ile Ala Asp Leu Trp Asn Ala Ser Glu 
            100                 105                 110         


Lys Glu Lys Phe Met Gly Thr Ser Thr Ile Gly Ser Ser Glu Ala Cys 
        115                 120                 125             


Met Leu Gly Gly Met Ala Met Lys Phe Ser Trp Arg Lys Arg Ala Glu 
    130                 135                 140                 


Lys Leu Gly Leu Asp Ile Asn Ala Lys Lys Pro Asn Leu Val Ile Ser 
145                 150                 155                 160 


Ser Gly Tyr Gln Val Cys Trp Glu Lys Phe Cys Ile Tyr Trp Asp Ile 
                165                 170                 175     


Glu Met Arg Glu Val Pro Met Asp Lys Glu His Met Ser Ile Asn Leu 
            180                 185                 190         


Asp Lys Val Met Asp Tyr Val Asp Glu Tyr Thr Ile Gly Val Val Gly 
        195                 200                 205             


Ile Met Gly Ile Thr Tyr Thr Gly Arg Tyr Asp Asp Ile Lys Ala Leu 
    210                 215                 220                 


Asp Asn Leu Ile Glu Glu Tyr Asn Lys Gln Thr Asp Tyr Lys Val Tyr 
225                 230                 235                 240 


Ile His Val Asp Ala Ala Ser Gly Gly Leu Tyr Ala Pro Phe Val Glu 
                245                 250                 255     


Pro Glu Leu Glu Trp Asp Phe Arg Leu Lys Asn Val Ile Ser Ile Asn 
            260                 265                 270         


Thr Ser Gly His Lys Tyr Gly Leu Val Tyr Pro Gly Val Gly Trp Val 
        275                 280                 285             


Leu Trp Arg Asp Lys Lys Tyr Leu Pro Glu Glu Leu Ile Phe Lys Val 
    290                 295                 300                 


Ser Tyr Leu Gly Gly Glu Leu Pro Thr Met Ala Ile Asn Phe Ser His 
305                 310                 315                 320 


Ser Ala Ser Gln Leu Ile Gly Gln Tyr Tyr Asn Phe Val Arg Tyr Gly 
                325                 330                 335     


Phe Asp Gly Tyr Lys Ala Ile His Glu Arg Thr His Lys Val Ala Met 
            340                 345                 350         


Phe Leu Ala Lys Glu Ile Glu Lys Thr Gly Met Phe Glu Ile Met Asn 
        355                 360                 365             


Asp Gly Ser Gln Leu Pro Ile Val Cys Tyr Lys Leu Lys Glu Asp Ser 
    370                 375                 380                 


Asn Arg Gly Trp Asn Leu Tyr Asp Leu Ala Asp Arg Leu Leu Met Lys 
385                 390                 395                 400 


Gly Trp Gln Val Pro Ala Tyr Pro Leu Pro Lys Asn Leu Glu Asn Glu 
                405                 410                 415     


Ile Ile Gln Arg Leu Val Ile Arg Ala Asp Phe Gly Met Asn Met Ala 
            420                 425                 430         


Phe Asn Tyr Val Gln Asp Met Gln Glu Ala Ile Glu Ala Leu Asn Lys 
        435                 440                 445             


Ala His Ile Leu Tyr His Glu Glu Pro Glu Asn Lys Thr Tyr Gly Phe 
    450                 455                 460                 


Thr Ala 
465     


<210>  32
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L. lactis subsp. cremoris GAD mutant E89Q

<400>  32

Met Leu Tyr Gly Lys Glu Asn Arg Asp Glu Ala Glu Phe Leu Glu Pro 
1               5                   10                  15      


Ile Phe Gly Ser Glu Ser Glu Gln Val Asp Leu Pro Lys Tyr Lys Leu 
            20                  25                  30          


Ala Gln Gln Ser Ile Glu Pro Arg Val Ala Tyr Gln Leu Val Gln Asp 
        35                  40                  45              


Glu Met Leu Asp Glu Gly Asn Ala Arg Leu Asn Leu Ala Thr Phe Cys 
    50                  55                  60                  


Gln Thr Tyr Met Glu Pro Glu Ala Val Lys Leu Met Ser Gln Thr Leu 
65                  70                  75                  80  


Glu Lys Asn Ala Ile Asp Lys Ser Gln Tyr Pro Arg Thr Thr Glu Ile 
                85                  90                  95      


Glu Asn Arg Cys Val Asn Met Ile Ala Asp Leu Trp Asn Ala Ser Glu 
            100                 105                 110         


Lys Glu Lys Phe Met Gly Thr Ser Thr Ile Gly Ser Ser Glu Ala Cys 
        115                 120                 125             


Met Leu Gly Gly Met Ala Met Lys Phe Ser Trp Arg Lys Arg Ala Glu 
    130                 135                 140                 


Lys Leu Gly Leu Asp Ile Asn Ala Lys Lys Pro Asn Leu Val Ile Ser 
145                 150                 155                 160 


Ser Gly Tyr Gln Val Cys Trp Glu Lys Phe Cys Val Tyr Trp Asp Ile 
                165                 170                 175     


Glu Met Arg Glu Val Pro Met Asp Arg Glu His Met Ser Ile Asn Leu 
            180                 185                 190         


Glu Lys Val Met Asp Tyr Val Asp Glu Tyr Thr Ile Gly Val Val Gly 
        195                 200                 205             


Ile Met Gly Ile Thr Tyr Thr Gly Arg Tyr Asp Asp Ile Lys Ala Leu 
    210                 215                 220                 


Asp Asn Leu Ile Glu Glu Tyr Asn Lys Gln Thr Asp Tyr Lys Val Tyr 
225                 230                 235                 240 


Ile His Val Asp Ala Ala Ser Gly Gly Leu Tyr Ala Pro Phe Val Glu 
                245                 250                 255     


Pro Glu Leu Glu Trp Asp Phe Arg Leu Lys Asn Val Ile Ser Ile Asn 
            260                 265                 270         


Thr Ser Gly His Lys Tyr Gly Leu Val Tyr Pro Gly Val Gly Trp Val 
        275                 280                 285             


Leu Trp Arg Asp Lys Lys Tyr Leu Pro Glu Glu Leu Ile Phe Lys Val 
    290                 295                 300                 


Ser Tyr Leu Gly Gly Glu Leu Pro Thr Met Ala Ile Asn Phe Ser His 
305                 310                 315                 320 


Ser Ala Ser Gln Leu Ile Gly Gln Tyr Tyr Asn Phe Val Arg Tyr Gly 
                325                 330                 335     


Phe Asp Gly Tyr Lys Ala Ile His Glu Arg Thr His Lys Val Ala Met 
            340                 345                 350         


Tyr Leu Ala Glu Glu Ile Glu Lys Thr Gly Met Phe Glu Ile Met Asn 
        355                 360                 365             


Asp Gly Ala Gln Leu Pro Ile Val Cys Tyr Lys Leu Lys Glu Asn Ser 
    370                 375                 380                 


Asn Arg Gly Trp Asn Leu Tyr Asp Leu Ala Asp Arg Leu Leu Met Lys 
385                 390                 395                 400 


Gly Trp Gln Val Pro Ala Tyr Pro Leu Pro Lys Asn Leu Glu Asn Glu 
                405                 410                 415     


Ile Ile Gln Arg Leu Val Ile Arg Ala Asp Phe Gly Met Asn Met Ala 
            420                 425                 430         


Phe Asn Tyr Val Gln Asp Met Gln Glu Ala Ile Asp Ala Leu Asn Lys 
        435                 440                 445             


Ala His Ile Leu Phe His Gln Glu Pro Glu Asn Lys Thr Tyr Gly Phe 
    450                 455                 460                 


Thr His 
465     


<210>  33
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L. lactis subsp. cremoris GAD mutant H466A

<400>  33

Met Leu Tyr Gly Lys Glu Asn Arg Asp Glu Ala Glu Phe Leu Glu Pro 
1               5                   10                  15      


Ile Phe Gly Ser Glu Ser Glu Gln Val Asp Leu Pro Lys Tyr Lys Leu 
            20                  25                  30          


Ala Gln Gln Ser Ile Glu Pro Arg Val Ala Tyr Gln Leu Val Gln Asp 
        35                  40                  45              


Glu Met Leu Asp Glu Gly Asn Ala Arg Leu Asn Leu Ala Thr Phe Cys 
    50                  55                  60                  


Gln Thr Tyr Met Glu Pro Glu Ala Val Lys Leu Met Ser Gln Thr Leu 
65                  70                  75                  80  


Glu Lys Asn Ala Ile Asp Lys Ser Glu Tyr Pro Arg Thr Thr Glu Ile 
                85                  90                  95      


Glu Asn Arg Cys Val Asn Met Ile Ala Asp Leu Trp Asn Ala Ser Glu 
            100                 105                 110         


Lys Glu Lys Phe Met Gly Thr Ser Thr Ile Gly Ser Ser Glu Ala Cys 
        115                 120                 125             


Met Leu Gly Gly Met Ala Met Lys Phe Ser Trp Arg Lys Arg Ala Glu 
    130                 135                 140                 


Lys Leu Gly Leu Asp Ile Asn Ala Lys Lys Pro Asn Leu Val Ile Ser 
145                 150                 155                 160 


Ser Gly Tyr Gln Val Cys Trp Glu Lys Phe Cys Val Tyr Trp Asp Ile 
                165                 170                 175     


Glu Met Arg Glu Val Pro Met Asp Arg Glu His Met Ser Ile Asn Leu 
            180                 185                 190         


Glu Lys Val Met Asp Tyr Val Asp Glu Tyr Thr Ile Gly Val Val Gly 
        195                 200                 205             


Ile Met Gly Ile Thr Tyr Thr Gly Arg Tyr Asp Asp Ile Lys Ala Leu 
    210                 215                 220                 


Asp Asn Leu Ile Glu Glu Tyr Asn Lys Gln Thr Asp Tyr Lys Val Tyr 
225                 230                 235                 240 


Ile His Val Asp Ala Ala Ser Gly Gly Leu Tyr Ala Pro Phe Val Glu 
                245                 250                 255     


Pro Glu Leu Glu Trp Asp Phe Arg Leu Lys Asn Val Ile Ser Ile Asn 
            260                 265                 270         


Thr Ser Gly His Lys Tyr Gly Leu Val Tyr Pro Gly Val Gly Trp Val 
        275                 280                 285             


Leu Trp Arg Asp Lys Lys Tyr Leu Pro Glu Glu Leu Ile Phe Lys Val 
    290                 295                 300                 


Ser Tyr Leu Gly Gly Glu Leu Pro Thr Met Ala Ile Asn Phe Ser His 
305                 310                 315                 320 


Ser Ala Ser Gln Leu Ile Gly Gln Tyr Tyr Asn Phe Val Arg Tyr Gly 
                325                 330                 335     


Phe Asp Gly Tyr Lys Ala Ile His Glu Arg Thr His Lys Val Ala Met 
            340                 345                 350         


Tyr Leu Ala Glu Glu Ile Glu Lys Thr Gly Met Phe Glu Ile Met Asn 
        355                 360                 365             


Asp Gly Ala Gln Leu Pro Ile Val Cys Tyr Lys Leu Lys Glu Asn Ser 
    370                 375                 380                 


Asn Arg Gly Trp Asn Leu Tyr Asp Leu Ala Asp Arg Leu Leu Met Lys 
385                 390                 395                 400 


Gly Trp Gln Val Pro Ala Tyr Pro Leu Pro Lys Asn Leu Glu Asn Glu 
                405                 410                 415     


Ile Ile Gln Arg Leu Val Ile Arg Ala Asp Phe Gly Met Asn Met Ala 
            420                 425                 430         


Phe Asn Tyr Val Gln Asp Met Gln Glu Ala Ile Asp Ala Leu Asn Lys 
        435                 440                 445             


Ala His Ile Leu Phe His Gln Glu Pro Glu Asn Lys Thr Tyr Gly Phe 
    450                 455                 460                 


Thr Ala 
465     


<210>  34
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L. lactis subsp. cremoris GAD mutant E89Q+H466A

<400>  34

Met Leu Tyr Gly Lys Glu Asn Arg Asp Glu Ala Glu Phe Leu Glu Pro 
1               5                   10                  15      


Ile Phe Gly Ser Glu Ser Glu Gln Val Asp Leu Pro Lys Tyr Lys Leu 
            20                  25                  30          


Ala Gln Gln Ser Ile Glu Pro Arg Val Ala Tyr Gln Leu Val Gln Asp 
        35                  40                  45              


Glu Met Leu Asp Glu Gly Asn Ala Arg Leu Asn Leu Ala Thr Phe Cys 
    50                  55                  60                  


Gln Thr Tyr Met Glu Pro Glu Ala Val Lys Leu Met Ser Gln Thr Leu 
65                  70                  75                  80  


Glu Lys Asn Ala Ile Asp Lys Ser Gln Tyr Pro Arg Thr Thr Glu Ile 
                85                  90                  95      


Glu Asn Arg Cys Val Asn Met Ile Ala Asp Leu Trp Asn Ala Ser Glu 
            100                 105                 110         


Lys Glu Lys Phe Met Gly Thr Ser Thr Ile Gly Ser Ser Glu Ala Cys 
        115                 120                 125             


Met Leu Gly Gly Met Ala Met Lys Phe Ser Trp Arg Lys Arg Ala Glu 
    130                 135                 140                 


Lys Leu Gly Leu Asp Ile Asn Ala Lys Lys Pro Asn Leu Val Ile Ser 
145                 150                 155                 160 


Ser Gly Tyr Gln Val Cys Trp Glu Lys Phe Cys Val Tyr Trp Asp Ile 
                165                 170                 175     


Glu Met Arg Glu Val Pro Met Asp Arg Glu His Met Ser Ile Asn Leu 
            180                 185                 190         


Glu Lys Val Met Asp Tyr Val Asp Glu Tyr Thr Ile Gly Val Val Gly 
        195                 200                 205             


Ile Met Gly Ile Thr Tyr Thr Gly Arg Tyr Asp Asp Ile Lys Ala Leu 
    210                 215                 220                 


Asp Asn Leu Ile Glu Glu Tyr Asn Lys Gln Thr Asp Tyr Lys Val Tyr 
225                 230                 235                 240 


Ile His Val Asp Ala Ala Ser Gly Gly Leu Tyr Ala Pro Phe Val Glu 
                245                 250                 255     


Pro Glu Leu Glu Trp Asp Phe Arg Leu Lys Asn Val Ile Ser Ile Asn 
            260                 265                 270         


Thr Ser Gly His Lys Tyr Gly Leu Val Tyr Pro Gly Val Gly Trp Val 
        275                 280                 285             


Leu Trp Arg Asp Lys Lys Tyr Leu Pro Glu Glu Leu Ile Phe Lys Val 
    290                 295                 300                 


Ser Tyr Leu Gly Gly Glu Leu Pro Thr Met Ala Ile Asn Phe Ser His 
305                 310                 315                 320 


Ser Ala Ser Gln Leu Ile Gly Gln Tyr Tyr Asn Phe Val Arg Tyr Gly 
                325                 330                 335     


Phe Asp Gly Tyr Lys Ala Ile His Glu Arg Thr His Lys Val Ala Met 
            340                 345                 350         


Tyr Leu Ala Glu Glu Ile Glu Lys Thr Gly Met Phe Glu Ile Met Asn 
        355                 360                 365             


Asp Gly Ala Gln Leu Pro Ile Val Cys Tyr Lys Leu Lys Glu Asn Ser 
    370                 375                 380                 


Asn Arg Gly Trp Asn Leu Tyr Asp Leu Ala Asp Arg Leu Leu Met Lys 
385                 390                 395                 400 


Gly Trp Gln Val Pro Ala Tyr Pro Leu Pro Lys Asn Leu Glu Asn Glu 
                405                 410                 415     


Ile Ile Gln Arg Leu Val Ile Arg Ala Asp Phe Gly Met Asn Met Ala 
            420                 425                 430         


Phe Asn Tyr Val Gln Asp Met Gln Glu Ala Ile Asp Ala Leu Asn Lys 
        435                 440                 445             


Ala His Ile Leu Phe His Gln Glu Pro Glu Asn Lys Thr Tyr Gly Phe 
    450                 455                 460                 


Thr Ala 
465     


<210>  35
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A. fischeri GAD mutant E89Q

<400>  35

Met Pro Leu His Ser Lys Asn Ala Val Arg Asp Asp Leu Leu Asp Asp 
1               5                   10                  15      


Ile Tyr Ser Ser Ala Asp Leu Ser Leu Ser Met Pro Lys Tyr Lys Met 
            20                  25                  30          


Pro Glu Gln Glu His Asp Pro Arg His Ala Tyr Gln Val Ile His Asp 
        35                  40                  45              


Glu Leu Met Met Asp Gly Asn Ser Arg Gln Asn Leu Ala Thr Phe Cys 
    50                  55                  60                  


Gln Thr Trp Val Glu Asp Glu Val His Lys Leu Met Asp Glu Cys Ile 
65                  70                  75                  80  


Asp Lys Asn Met Ile Asp Lys Asp Gln Tyr Pro Gln Thr Ala Glu Leu 
                85                  90                  95      


Glu Ser Arg Cys Val His Met Leu Ala Asp Leu Trp Asn Ser Pro Asp 
            100                 105                 110         


Ala Glu Asn Thr Leu Gly Cys Ser Thr Thr Gly Ser Ser Glu Ala Ala 
        115                 120                 125             


Met Leu Gly Gly Met Ala Leu Lys Trp Ala Trp Arg Glu Lys Met Lys 
    130                 135                 140                 


Lys Leu Gly Lys Pro Thr Asp Lys Pro Asn Met Ile Cys Gly Pro Val 
145                 150                 155                 160 


Gln Val Cys Trp His Lys Phe Ala Arg Tyr Trp Asp Ile Glu Leu Arg 
                165                 170                 175     


Glu Ile Pro Met Glu Gly Asp Arg Leu Ile Met Thr Pro Glu Glu Val 
            180                 185                 190         


Ile Lys Arg Cys Asp Glu Asn Thr Ile Gly Val Val Pro Thr Leu Gly 
        195                 200                 205             


Val Thr Phe Thr Cys Gln Tyr Glu Pro Val Lys Ala Val His Glu Ala 
    210                 215                 220                 


Leu Asp Lys Leu Gln Glu Glu Thr Gly Leu Asp Ile Pro Met His Ile 
225                 230                 235                 240 


Asp Ala Ala Ser Gly Gly Phe Leu Ala Pro Phe Cys Asp Pro Asp Leu 
                245                 250                 255     


Glu Trp Asp Phe Arg Leu Pro Arg Val Lys Ser Ile Asn Ala Ser Gly 
            260                 265                 270         


His Lys Phe Gly Leu Ser Pro Leu Gly Val Gly Trp Val Ile Trp Arg 
        275                 280                 285             


Asp Ala Ser Ala Leu His Glu Asp Leu Ile Phe Asn Val Asn Tyr Leu 
    290                 295                 300                 


Gly Gly Asn Met Pro Thr Phe Ala Leu Asn Phe Ser Arg Pro Gly Gly 
305                 310                 315                 320 


Gln Ile Val Ala Gln Tyr Tyr Asn Phe Leu Arg Leu Gly Lys Glu Gly 
                325                 330                 335     


Tyr Arg Lys Ile His Gln Ala Cys Tyr Asp Thr Ala Val Tyr Leu Ser 
            340                 345                 350         


Ser Glu Ile Glu Lys Leu Gly Met Phe Glu Ile Ile Tyr Asp Gly Lys 
        355                 360                 365             


Gly Gly Ile Pro Ala Met Ser Trp Ser Leu Lys Glu Gly Val Asp Pro 
    370                 375                 380                 


Gly Phe Asn Leu Phe Asp Leu Ser Asp Arg Ile Arg Ser Arg Gly Trp 
385                 390                 395                 400 


Gln Ile Ala Ala Tyr Ala Met Pro Pro Lys Arg Glu Asp Leu Val Ile 
                405                 410                 415     


Met Arg Ile Leu Val Arg His Gly Phe Ser Arg Asp Gln Ala Asp Leu 
            420                 425                 430         


Leu Val Ala Asp Leu Lys His Cys Val Glu Phe Phe Ala Lys His Pro 
        435                 440                 445             


Ile Ser His Gly Ser Asp Glu Leu Glu Ser Ser Gly Phe Asn His Gly 
    450                 455                 460                 


<210>  36
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A. fischeri GAD mutant H463A

<400>  36

Met Pro Leu His Ser Lys Asn Ala Val Arg Asp Asp Leu Leu Asp Asp 
1               5                   10                  15      


Ile Tyr Ser Ser Ala Asp Leu Ser Leu Ser Met Pro Lys Tyr Lys Met 
            20                  25                  30          


Pro Glu Gln Glu His Asp Pro Arg His Ala Tyr Gln Val Ile His Asp 
        35                  40                  45              


Glu Leu Met Met Asp Gly Asn Ser Arg Gln Asn Leu Ala Thr Phe Cys 
    50                  55                  60                  


Gln Thr Trp Val Glu Asp Glu Val His Lys Leu Met Asp Glu Cys Ile 
65                  70                  75                  80  


Asp Lys Asn Met Ile Asp Lys Asp Glu Tyr Pro Gln Thr Ala Glu Leu 
                85                  90                  95      


Glu Ser Arg Cys Val His Met Leu Ala Asp Leu Trp Asn Ser Pro Asp 
            100                 105                 110         


Ala Glu Asn Thr Leu Gly Cys Ser Thr Thr Gly Ser Ser Glu Ala Ala 
        115                 120                 125             


Met Leu Gly Gly Met Ala Leu Lys Trp Ala Trp Arg Glu Lys Met Lys 
    130                 135                 140                 


Lys Leu Gly Lys Pro Thr Asp Lys Pro Asn Met Ile Cys Gly Pro Val 
145                 150                 155                 160 


Gln Val Cys Trp His Lys Phe Ala Arg Tyr Trp Asp Ile Glu Leu Arg 
                165                 170                 175     


Glu Ile Pro Met Glu Gly Asp Arg Leu Ile Met Thr Pro Glu Glu Val 
            180                 185                 190         


Ile Lys Arg Cys Asp Glu Asn Thr Ile Gly Val Val Pro Thr Leu Gly 
        195                 200                 205             


Val Thr Phe Thr Cys Gln Tyr Glu Pro Val Lys Ala Val His Glu Ala 
    210                 215                 220                 


Leu Asp Lys Leu Gln Glu Glu Thr Gly Leu Asp Ile Pro Met His Ile 
225                 230                 235                 240 


Asp Ala Ala Ser Gly Gly Phe Leu Ala Pro Phe Cys Asp Pro Asp Leu 
                245                 250                 255     


Glu Trp Asp Phe Arg Leu Pro Arg Val Lys Ser Ile Asn Ala Ser Gly 
            260                 265                 270         


His Lys Phe Gly Leu Ser Pro Leu Gly Val Gly Trp Val Ile Trp Arg 
        275                 280                 285             


Asp Ala Ser Ala Leu His Glu Asp Leu Ile Phe Asn Val Asn Tyr Leu 
    290                 295                 300                 


Gly Gly Asn Met Pro Thr Phe Ala Leu Asn Phe Ser Arg Pro Gly Gly 
305                 310                 315                 320 


Gln Ile Val Ala Gln Tyr Tyr Asn Phe Leu Arg Leu Gly Lys Glu Gly 
                325                 330                 335     


Tyr Arg Lys Ile His Gln Ala Cys Tyr Asp Thr Ala Val Tyr Leu Ser 
            340                 345                 350         


Ser Glu Ile Glu Lys Leu Gly Met Phe Glu Ile Ile Tyr Asp Gly Lys 
        355                 360                 365             


Gly Gly Ile Pro Ala Met Ser Trp Ser Leu Lys Glu Gly Val Asp Pro 
    370                 375                 380                 


Gly Phe Asn Leu Phe Asp Leu Ser Asp Arg Ile Arg Ser Arg Gly Trp 
385                 390                 395                 400 


Gln Ile Ala Ala Tyr Ala Met Pro Pro Lys Arg Glu Asp Leu Val Ile 
                405                 410                 415     


Met Arg Ile Leu Val Arg His Gly Phe Ser Arg Asp Gln Ala Asp Leu 
            420                 425                 430         


Leu Val Ala Asp Leu Lys His Cys Val Glu Phe Phe Ala Lys His Pro 
        435                 440                 445             


Ile Ser His Gly Ser Asp Glu Leu Glu Ser Ser Gly Phe Asn Ala Gly 
    450                 455                 460                 


<210>  37
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A. fischeri GAD mutant E89Q+H463A

<400>  37

Met Pro Leu His Ser Lys Asn Ala Val Arg Asp Asp Leu Leu Asp Asp 
1               5                   10                  15      


Ile Tyr Ser Ser Ala Asp Leu Ser Leu Ser Met Pro Lys Tyr Lys Met 
            20                  25                  30          


Pro Glu Gln Glu His Asp Pro Arg His Ala Tyr Gln Val Ile His Asp 
        35                  40                  45              


Glu Leu Met Met Asp Gly Asn Ser Arg Gln Asn Leu Ala Thr Phe Cys 
    50                  55                  60                  


Gln Thr Trp Val Glu Asp Glu Val His Lys Leu Met Asp Glu Cys Ile 
65                  70                  75                  80  


Asp Lys Asn Met Ile Asp Lys Asp Gln Tyr Pro Gln Thr Ala Glu Leu 
                85                  90                  95      


Glu Ser Arg Cys Val His Met Leu Ala Asp Leu Trp Asn Ser Pro Asp 
            100                 105                 110         


Ala Glu Asn Thr Leu Gly Cys Ser Thr Thr Gly Ser Ser Glu Ala Ala 
        115                 120                 125             


Met Leu Gly Gly Met Ala Leu Lys Trp Ala Trp Arg Glu Lys Met Lys 
    130                 135                 140                 


Lys Leu Gly Lys Pro Thr Asp Lys Pro Asn Met Ile Cys Gly Pro Val 
145                 150                 155                 160 


Gln Val Cys Trp His Lys Phe Ala Arg Tyr Trp Asp Ile Glu Leu Arg 
                165                 170                 175     


Glu Ile Pro Met Glu Gly Asp Arg Leu Ile Met Thr Pro Glu Glu Val 
            180                 185                 190         


Ile Lys Arg Cys Asp Glu Asn Thr Ile Gly Val Val Pro Thr Leu Gly 
        195                 200                 205             


Val Thr Phe Thr Cys Gln Tyr Glu Pro Val Lys Ala Val His Glu Ala 
    210                 215                 220                 


Leu Asp Lys Leu Gln Glu Glu Thr Gly Leu Asp Ile Pro Met His Ile 
225                 230                 235                 240 


Asp Ala Ala Ser Gly Gly Phe Leu Ala Pro Phe Cys Asp Pro Asp Leu 
                245                 250                 255     


Glu Trp Asp Phe Arg Leu Pro Arg Val Lys Ser Ile Asn Ala Ser Gly 
            260                 265                 270         


His Lys Phe Gly Leu Ser Pro Leu Gly Val Gly Trp Val Ile Trp Arg 
        275                 280                 285             


Asp Ala Ser Ala Leu His Glu Asp Leu Ile Phe Asn Val Asn Tyr Leu 
    290                 295                 300                 


Gly Gly Asn Met Pro Thr Phe Ala Leu Asn Phe Ser Arg Pro Gly Gly 
305                 310                 315                 320 


Gln Ile Val Ala Gln Tyr Tyr Asn Phe Leu Arg Leu Gly Lys Glu Gly 
                325                 330                 335     


Tyr Arg Lys Ile His Gln Ala Cys Tyr Asp Thr Ala Val Tyr Leu Ser 
            340                 345                 350         


Ser Glu Ile Glu Lys Leu Gly Met Phe Glu Ile Ile Tyr Asp Gly Lys 
        355                 360                 365             


Gly Gly Ile Pro Ala Met Ser Trp Ser Leu Lys Glu Gly Val Asp Pro 
    370                 375                 380                 


Gly Phe Asn Leu Phe Asp Leu Ser Asp Arg Ile Arg Ser Arg Gly Trp 
385                 390                 395                 400 


Gln Ile Ala Ala Tyr Ala Met Pro Pro Lys Arg Glu Asp Leu Val Ile 
                405                 410                 415     


Met Arg Ile Leu Val Arg His Gly Phe Ser Arg Asp Gln Ala Asp Leu 
            420                 425                 430         


Leu Val Ala Asp Leu Lys His Cys Val Glu Phe Phe Ala Lys His Pro 
        435                 440                 445             


Ile Ser His Gly Ser Asp Glu Leu Glu Ser Ser Gly Phe Asn Ala Gly 
    450                 455                 460                 


<210>  38
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L. brevis GAD 4AA mutant

<400>  38

Met Ala Met Leu Tyr Gly Lys His Thr His Glu Thr Asp Glu Thr Leu 
1               5                   10                  15      


Ile Pro Ile Phe Gly Ala Thr Ala Glu Arg His Asp Leu Pro Lys Tyr 
            20                  25                  30          


Lys Leu Ala Lys His Ala Leu Glu Pro Arg Glu Ala Asp Arg Leu Val 
        35                  40                  45              


Arg Asp Gln Leu Leu Asp Glu Gly Asn Ser Arg Leu Asn Leu Ala Thr 
    50                  55                  60                  


Phe Cys Gln Thr Tyr Met Glu Pro Glu Ala Val Glu Leu Met Lys Asp 
65                  70                  75                  80  


Thr Leu Glu Lys Asn Ala Ile Asp Lys Ser Glu Tyr Pro Arg Thr Ala 
                85                  90                  95      


Glu Ile Glu Asn Arg Cys Val Asn Ile Ile Ala Asn Leu Trp His Ala 
            100                 105                 110         


Pro Glu Ala Glu Ser Phe Thr Gly Thr Ser Thr Ile Gly Ser Ser Glu 
        115                 120                 125             


Ala Cys Met Leu Ala Gly Leu Ala Met Lys Phe Ala Trp Arg Lys Arg 
    130                 135                 140                 


Ala Lys Ala Asn Gly Leu Asp Leu Thr Ala His Gln Pro Asn Ile Val 
145                 150                 155                 160 


Ile Ser Ala Gly Tyr Gln Val Cys Trp Glu Lys Phe Cys Val Tyr Trp 
                165                 170                 175     


Asp Ile Asp Met His Val Val Pro Met Asp Asp Asp His Met Ser Leu 
            180                 185                 190         


Asn Val Asp His Val Leu Asp Tyr Val Asp Asp Tyr Thr Ile Gly Ile 
        195                 200                 205             


Val Gly Ile Met Gly Ile Thr Tyr Thr Gly Gln Tyr Asp Asp Leu Ala 
    210                 215                 220                 


Arg Leu Asp Ala Val Val Glu Arg Tyr Asn Arg Thr Thr Lys Phe Pro 
225                 230                 235                 240 


Val Tyr Ile His Val Asp Ala Ala Ser Gly Gly Phe Tyr Thr Pro Phe 
                245                 250                 255     


Ile Glu Pro Glu Leu Lys Trp Asp Phe Arg Leu Asn Asn Val Ile Ser 
            260                 265                 270         


Ile Asn Ala Ser Gly His Lys Tyr Gly Leu Val Tyr Pro Gly Val Gly 
        275                 280                 285             


Trp Val Ile Trp Arg Gly Gln Gln Tyr Leu Pro Lys Glu Leu Val Phe 
    290                 295                 300                 


Lys Val Ser Tyr Leu Gly Gly Ser Leu Pro Thr Met Ala Ile Asn Phe 
305                 310                 315                 320 


Ser His Ser Ala Ser Gln Leu Ile Gly Gln Tyr Tyr Asn Phe Ile Arg 
                325                 330                 335     


Phe Gly Phe Asp Gly Tyr Arg Glu Ile His Glu Lys Thr His Asp Val 
            340                 345                 350         


Ala Arg Tyr Leu Ala Lys Ser Leu Thr Lys Leu Gly Gly Phe Ser Leu 
        355                 360                 365             


Ile Asn Asp Gly His Glu Leu Pro Leu Ile Cys Tyr Glu Leu Thr Ala 
    370                 375                 380                 


Asp Ser Asp Arg Glu Trp Thr Leu Tyr Asp Leu Ser Asp Arg Leu Leu 
385                 390                 395                 400 


Met Lys Gly Trp Gln Val Pro Thr Tyr Pro Leu Pro Lys Asn Met Thr 
                405                 410                 415     


Asp Arg Val Ile Gln Arg Ile Val Val Arg Ala Asp Phe Gly Met Ser 
            420                 425                 430         


Met Ala His Asp Phe Ile Asp Asp Leu Thr Gln Ala Ile His Asp Leu 
        435                 440                 445             


Asp Gln Ala His Ile Val Phe His Ser Asp Pro Gln Pro Lys Lys Tyr 
    450                 455                 460                 


Gly Phe Thr His 
465             


<210>  39
<211>  614
<212>  PRT
<213>  Euglena gracilis

<400>  39

Met Gly Ile Ala Leu Asp Gly Pro Asp Arg Asp Arg Met Phe Asn Ala 
1               5                   10                  15      


Tyr Leu His Ser Ser Arg Pro Ser Phe Gly Pro Ala Thr Asp Val Phe 
            20                  25                  30          


Val Gln Cys Leu Glu Ala Glu Lys Ile Asp Trp Ile Phe Gly Ile Pro 
        35                  40                  45              


Gly Glu Glu Asn Leu Asp Leu Leu His Ser Leu Ala Lys Ala His Arg 
    50                  55                  60                  


Arg Glu Gly Gly Glu Thr Met Lys Leu Val Val Thr Arg His Glu Gln 
65                  70                  75                  80  


Ala Ala Gly Phe Met Ala Ala Thr Val Gly Arg Leu Thr Gly His Pro 
                85                  90                  95      


Ala Ala Cys Leu Ser Thr Leu Gly Pro Gly Ala Thr Asn Phe Thr Thr 
            100                 105                 110         


Ala Leu Ala Tyr Ser Lys Leu Gly Gly Phe Pro Leu Ile Cys Ile Thr 
        115                 120                 125             


Gly Gln Lys Pro Ile Arg His Ser Lys Gln Gly Ala Phe Gln Ile Leu 
    130                 135                 140                 


Asp Ile Cys Gly His Phe Arg Asp Val Val Lys Ser Thr Lys Ser Ile 
145                 150                 155                 160 


Glu Asp Pro Asp Leu Ile Pro Ser Thr Ile Arg Asn Ala Val Leu Gln 
                165                 170                 175     


Ala Arg Glu Glu Lys Pro Gly Pro Val His Ile Glu Leu Ala Glu Asp 
            180                 185                 190         


Ile Ala Ala Leu Glu Val Ser Lys Glu Gly Gly Trp Val Phe Pro Ala 
        195                 200                 205             


Pro Thr Arg Thr Pro Ile Ala Arg Gly Arg Arg Pro Leu Val Glu Pro 
    210                 215                 220                 


Lys Cys Ile Glu His Ala Val Thr Leu Ile His Ala Ala Lys Arg Pro 
225                 230                 235                 240 


Leu Ile Cys Ile Ala Ala Gly Ala Asn Arg Lys Asn Thr His His Ala 
                245                 250                 255     


Met Glu Val Leu Met Arg Lys Thr Gly Leu Met Val Val Cys Thr Gln 
            260                 265                 270         


Met Gly Lys Gly Val Val Tyr Glu Asp Asn Leu Gly Tyr Ile Gly Cys 
        275                 280                 285             


Thr Ala Leu Ser Asp Lys Asp Leu Val His Val Ala Ile Asn Thr Ala 
    290                 295                 300                 


Asp Leu Ile Val Asn Val Gly His Asp Ile Ser Glu Lys Pro Pro Phe 
305                 310                 315                 320 


Ile Met Asn His Asn Lys Pro Pro Leu Val Ile His Ala Asn Phe Thr 
                325                 330                 335     


Arg Pro Leu Val Asp Pro Val Tyr Phe Pro His Leu Val Leu Val Gly 
            340                 345                 350         


Asp Ile Asn Asp Cys Leu Trp Gln Leu Ala Thr Arg Ile Arg Pro Gln 
        355                 360                 365             


Pro His Trp Asp Phe Asn Pro Phe Gln Met Val Arg Arg Glu Ile Glu 
    370                 375                 380                 


Arg Thr Val Trp Asn Ser Pro Tyr Ala Gln Ser Asp Ala Phe Pro Leu 
385                 390                 395                 400 


Thr Val Gln Arg Leu Val Ser Asp Val Arg Lys Ala Met Pro Val Asp 
                405                 410                 415     


Gly Ile Val Ser Leu Asp Asn Gly Met Tyr Lys Ile Trp Phe Ala Arg 
            420                 425                 430         


Gln Tyr Lys Thr Met Met Gly Asn Thr Leu Leu Leu Asp Asn Ala Leu 
        435                 440                 445             


Ala Thr Met Gly Ala Gly Leu Pro Ser Cys Ile Ala Ala Lys Leu Val 
    450                 455                 460                 


Tyr Pro Glu Arg Val Cys Ile Ala Val Cys Gly Asp Gly Gly Phe Met 
465                 470                 475                 480 


Met Asn Ser Gln Glu Ile Glu Thr Ala Leu Arg Leu Asn Leu His Ile 
                485                 490                 495     


Val Val Ile Val Leu Asn Asn Asn Ser Tyr Gly Met Ile Ala Trp Lys 
            500                 505                 510         


Ala Thr Ala Met Gly Met Asp Asp Phe Gly Leu Asn Tyr Gly Asn Pro 
        515                 520                 525             


Asp Phe Ala Gln Tyr Ala Arg Ala Tyr Gly Ala Ile Gly His Asn Val 
    530                 535                 540                 


Lys Ser Thr Ala Glu Phe Leu Pro Thr Leu Glu Lys Ala Ile Lys Glu 
545                 550                 555                 560 


His Gly Val His Ile Ile Asp Leu Pro Ile Ser Tyr Glu Thr Ser Asp 
                565                 570                 575     


Lys Ala Leu Phe Glu Asp Leu Pro Lys Glu Val Glu Glu Leu Lys Lys 
            580                 585                 590         


Ala Val Ala Lys Ala Ile Ser Glu Glu Lys Lys Phe Asp Trp Asp Ala 
        595                 600                 605             


Val Thr Ala Ala Gln Ser 
    610                 


<210>  40
<211>  545
<212>  PRT
<213>  Synechococcus sp.

<400>  40

Met Asn Thr Ala Glu Leu Leu Ile Arg Cys Leu Glu Asn Glu Gly Val 
1               5                   10                  15      


Glu Tyr Ile Phe Gly Leu Pro Gly Glu Glu Asn Leu His Ile Leu Glu 
            20                  25                  30          


Ala Leu Lys Glu Ser Pro Ile Arg Phe Ile Thr Val Arg His Glu Gln 
        35                  40                  45              


Gly Ala Ala Phe Met Ala Asp Val Tyr Gly Arg Leu Thr Gly Lys Ala 
    50                  55                  60                  


Gly Val Cys Leu Ser Thr Leu Gly Pro Gly Ala Thr Asn Leu Met Thr 
65                  70                  75                  80  


Gly Val Ala Asp Ala Asn Leu Asp Gly Ala Pro Leu Ile Ala Ile Thr 
                85                  90                  95      


Gly Gln Val Gly Thr Asp Arg Met His Ile Glu Ser His Gln Tyr Leu 
            100                 105                 110         


Asp Leu Val Ala Met Phe Ala Pro Val Thr Lys Trp Asn Lys Gln Ile 
        115                 120                 125             


Val Arg Pro Asn Thr Thr Pro Glu Val Val Arg Arg Ala Phe Lys Ile 
    130                 135                 140                 


Ala Gln Gln Glu Lys Pro Gly Ala Val His Ile Asp Leu Pro Glu Asn 
145                 150                 155                 160 


Ile Ala Ala Met Pro Val Glu Gly Gln Pro Leu Gln Arg Asp Gly Arg 
                165                 170                 175     


Glu Lys Ile Tyr Ala Ser Ser Arg Ser Leu Asn Arg Ala Ala Glu Ala 
            180                 185                 190         


Ile Ala His Ala Lys Ser Pro Leu Ile Leu Val Gly Asn Gly Ile Ile 
        195                 200                 205             


Arg Ala Asp Ala Ala Glu Ala Leu Thr Asp Phe Ala Thr Gln Leu Asn 
    210                 215                 220                 


Ile Pro Val Val Asn Thr Phe Met Gly Lys Gly Ala Ile Pro Tyr Thr 
225                 230                 235                 240 


His Pro Leu Ser Leu Trp Thr Val Gly Leu Gln Gln Arg Asp Phe Val 
                245                 250                 255     


Thr Cys Ala Phe Glu Gln Ser Asp Leu Val Ile Ala Val Gly Tyr Asp 
            260                 265                 270         


Leu Ile Glu Tyr Ser Pro Lys Arg Trp Asn Pro Glu Gly Thr Thr Pro 
        275                 280                 285             


Ile Ile His Ile Gly Glu Val Ala Ala Glu Ile Asp Ser Ser Tyr Ile 
    290                 295                 300                 


Pro Leu Thr Glu Val Val Gly Asp Ile Gly Asp Ala Leu Asn Glu Ile 
305                 310                 315                 320 


Arg Lys Arg Thr Asp Arg Glu Gly Lys Thr Ala Pro Lys Phe Leu Asn 
                325                 330                 335     


Val Arg Ala Glu Ile Arg Glu Asp Tyr Glu Arg His Gly Thr Asp Ala 
            340                 345                 350         


Ser Phe Pro Val Lys Pro Gln Lys Ile Ile Tyr Asp Leu Arg Gln Val 
        355                 360                 365             


Met Ala Pro Glu Asp Ile Val Ile Ser Asp Val Gly Ala His Lys Met 
    370                 375                 380                 


Trp Met Ala Arg His Tyr His Cys Asp Arg Pro Asn Thr Cys Leu Ile 
385                 390                 395                 400 


Ser Asn Gly Phe Ala Ala Met Gly Ile Ala Ile Pro Gly Ala Val Ala 
                405                 410                 415     


Ala Lys Leu Val Tyr Pro Glu Lys Asn Val Val Ala Val Thr Gly Asp 
            420                 425                 430         


Gly Gly Phe Met Met Asn Cys Gln Glu Leu Glu Thr Ala Leu Arg Ile 
        435                 440                 445             


Gly Ala Asn Phe Val Thr Leu Ile Phe Asn Asp Gly Gly Tyr Gly Leu 
    450                 455                 460                 


Ile Gly Trp Lys Gln Ile Asn Gln Phe Gly Ala Pro Ala Phe Val Glu 
465                 470                 475                 480 


Phe Gly Asn Pro Asp Phe Val Gln Phe Ala Glu Ser Met Gly Leu Lys 
                485                 490                 495     


Gly Tyr Arg Ile Thr Ala Ala Ala Asp Leu Val Pro Thr Leu Lys Glu 
            500                 505                 510         


Ala Leu Ala Gln Asp Val Pro Ala Val Ile Asp Cys Pro Val Asp Tyr 
        515                 520                 525             


Ser Glu Asn Val Lys Phe Ser Gln Lys Ser Gly Asp Leu Ile Cys Arg 
    530                 535                 540                 


Met 
545 


<210>  41
<211>  1231
<212>  PRT
<213>  M. tuberculosis

<400>  41

Met Ala Asn Ile Ser Ser Pro Phe Gly Gln Asn Glu Trp Leu Val Glu 
1               5                   10                  15      


Glu Met Tyr Arg Lys Phe Arg Asp Asp Pro Ser Ser Val Asp Pro Ser 
            20                  25                  30          


Trp His Glu Phe Leu Val Asp Tyr Ser Pro Glu Pro Thr Ser Gln Pro 
        35                  40                  45              


Ala Ala Glu Pro Thr Arg Val Thr Ser Pro Leu Val Ala Glu Arg Ala 
    50                  55                  60                  


Ala Ala Ala Ala Pro Gln Ala Pro Pro Lys Pro Ala Asp Thr Ala Ala 
65                  70                  75                  80  


Ala Gly Asn Gly Val Val Ala Ala Leu Ala Ala Lys Thr Ala Val Pro 
                85                  90                  95      


Pro Pro Ala Glu Gly Asp Glu Val Ala Val Leu Arg Gly Ala Ala Ala 
            100                 105                 110         


Ala Val Val Lys Asn Met Ser Ala Ser Leu Glu Val Pro Thr Ala Thr 
        115                 120                 125             


Ser Val Arg Ala Val Pro Ala Lys Leu Leu Ile Asp Asn Arg Ile Val 
    130                 135                 140                 


Ile Asn Asn Gln Leu Lys Arg Thr Arg Gly Gly Lys Ile Ser Phe Thr 
145                 150                 155                 160 


His Leu Leu Gly Tyr Ala Leu Val Gln Ala Val Lys Lys Phe Pro Asn 
                165                 170                 175     


Met Asn Arg His Tyr Thr Glu Val Asp Gly Lys Pro Thr Ala Val Thr 
            180                 185                 190         


Pro Ala His Thr Asn Leu Gly Leu Ala Ile Asp Leu Gln Gly Lys Asp 
        195                 200                 205             


Gly Lys Arg Ser Leu Val Val Ala Gly Ile Lys Arg Cys Glu Thr Met 
    210                 215                 220                 


Arg Phe Ala Gln Phe Val Thr Ala Tyr Glu Asp Ile Val Arg Arg Ala 
225                 230                 235                 240 


Arg Asp Gly Lys Leu Thr Thr Glu Asp Phe Ala Gly Val Thr Ile Ser 
                245                 250                 255     


Leu Thr Asn Pro Gly Thr Ile Gly Thr Val His Ser Val Pro Arg Leu 
            260                 265                 270         


Met Pro Gly Gln Gly Ala Ile Ile Gly Val Gly Ala Met Glu Tyr Pro 
        275                 280                 285             


Ala Glu Phe Gln Gly Ala Ser Glu Glu Arg Ile Ala Glu Leu Gly Ile 
    290                 295                 300                 


Gly Lys Leu Ile Thr Leu Thr Ser Thr Tyr Asp His Arg Ile Ile Gln 
305                 310                 315                 320 


Gly Ala Glu Ser Gly Asp Phe Leu Arg Thr Ile His Glu Leu Leu Leu 
                325                 330                 335     


Ser Asp Gly Phe Trp Asp Glu Val Phe Arg Glu Leu Ser Ile Pro Tyr 
            340                 345                 350         


Leu Pro Val Arg Trp Ser Thr Asp Asn Pro Asp Ser Ile Val Asp Lys 
        355                 360                 365             


Asn Ala Arg Val Met Asn Leu Ile Ala Ala Tyr Arg Asn Arg Gly His 
    370                 375                 380                 


Leu Met Ala Asp Thr Asp Pro Leu Arg Leu Asp Lys Ala Arg Phe Arg 
385                 390                 395                 400 


Ser His Pro Asp Leu Glu Val Leu Thr His Gly Leu Thr Leu Trp Asp 
                405                 410                 415     


Leu Asp Arg Val Phe Lys Val Asp Gly Phe Ala Gly Ala Gln Tyr Lys 
            420                 425                 430         


Lys Leu Arg Asp Val Leu Gly Leu Leu Arg Asp Ala Tyr Cys Arg His 
        435                 440                 445             


Ile Gly Val Glu Tyr Ala His Ile Leu Asp Pro Glu Gln Lys Glu Trp 
    450                 455                 460                 


Leu Glu Gln Arg Val Glu Thr Lys His Val Lys Pro Thr Val Ala Gln 
465                 470                 475                 480 


Gln Lys Tyr Ile Leu Ser Lys Leu Asn Ala Ala Glu Ala Phe Glu Thr 
                485                 490                 495     


Phe Leu Gln Thr Lys Tyr Val Gly Gln Lys Arg Phe Ser Leu Glu Gly 
            500                 505                 510         


Ala Glu Ser Val Ile Pro Met Met Asp Ala Ala Ile Asp Gln Cys Ala 
        515                 520                 525             


Glu His Gly Leu Asp Glu Val Val Ile Gly Met Pro His Arg Gly Arg 
    530                 535                 540                 


Leu Asn Val Leu Ala Asn Ile Val Gly Lys Pro Tyr Ser Gln Ile Phe 
545                 550                 555                 560 


Thr Glu Phe Glu Gly Asn Leu Asn Pro Ser Gln Ala His Gly Ser Gly 
                565                 570                 575     


Asp Val Lys Tyr His Leu Gly Ala Thr Gly Leu Tyr Leu Gln Met Phe 
            580                 585                 590         


Gly Asp Asn Asp Ile Gln Val Ser Leu Thr Ala Asn Pro Ser His Leu 
        595                 600                 605             


Glu Ala Val Asp Pro Val Leu Glu Gly Leu Val Arg Ala Lys Gln Asp 
    610                 615                 620                 


Leu Leu Asp His Gly Ser Ile Asp Ser Asp Gly Gln Arg Ala Phe Ser 
625                 630                 635                 640 


Val Val Pro Leu Met Leu His Gly Asp Ala Ala Phe Ala Gly Gln Gly 
                645                 650                 655     


Val Val Ala Glu Thr Leu Asn Leu Ala Asn Leu Pro Gly Tyr Arg Val 
            660                 665                 670         


Gly Gly Thr Ile His Ile Ile Val Asn Asn Gln Ile Gly Phe Thr Thr 
        675                 680                 685             


Ala Pro Glu Tyr Ser Arg Ser Ser Glu Tyr Cys Thr Asp Val Ala Lys 
    690                 695                 700                 


Met Ile Gly Ala Pro Ile Phe His Val Asn Gly Asp Asp Pro Glu Ala 
705                 710                 715                 720 


Cys Val Trp Val Ala Arg Leu Ala Val Asp Phe Arg Gln Arg Phe Lys 
                725                 730                 735     


Lys Asp Val Val Ile Asp Met Leu Cys Tyr Arg Arg Arg Gly His Asn 
            740                 745                 750         


Glu Gly Asp Asp Pro Ser Met Thr Asn Pro Tyr Val Tyr Asp Val Val 
        755                 760                 765             


Asp Thr Lys Arg Gly Ala Arg Lys Ser Tyr Thr Glu Ala Leu Ile Gly 
    770                 775                 780                 


Arg Gly Asp Ile Ser Met Lys Glu Ala Glu Asp Ala Leu Arg Asp Tyr 
785                 790                 795                 800 


Gln Gly Gln Leu Glu Arg Val Phe Asn Glu Val Arg Glu Leu Glu Lys 
                805                 810                 815     


His Gly Val Gln Pro Ser Glu Ser Val Glu Ser Asp Gln Met Ile Pro 
            820                 825                 830         


Ala Gly Leu Ala Thr Ala Val Asp Lys Ser Leu Leu Ala Arg Ile Gly 
        835                 840                 845             


Asp Ala Phe Leu Ala Leu Pro Asn Gly Phe Thr Ala His Pro Arg Val 
    850                 855                 860                 


Gln Pro Val Leu Glu Lys Arg Arg Glu Met Ala Tyr Glu Gly Lys Ile 
865                 870                 875                 880 


Asp Trp Ala Phe Gly Glu Leu Leu Ala Leu Gly Ser Leu Val Ala Glu 
                885                 890                 895     


Gly Lys Leu Val Arg Leu Ser Gly Gln Asp Ser Arg Arg Gly Thr Phe 
            900                 905                 910         


Ser Gln Arg His Ser Val Leu Ile Asp Arg His Thr Gly Glu Glu Phe 
        915                 920                 925             


Thr Pro Leu Gln Leu Leu Ala Thr Asn Ser Asp Gly Ser Pro Thr Gly 
    930                 935                 940                 


Gly Lys Phe Leu Val Tyr Asp Ser Pro Leu Ser Glu Tyr Ala Ala Val 
945                 950                 955                 960 


Gly Phe Glu Tyr Gly Tyr Thr Val Gly Asn Pro Asp Ala Val Val Leu 
                965                 970                 975     


Trp Glu Ala Gln Phe Gly Asp Phe Val Asn Gly Ala Gln Ser Ile Ile 
            980                 985                 990         


Asp Glu Phe Ile Ser Ser Gly Glu  Ala Lys Trp Gly Gln  Leu Ser Asn 
        995                 1000                 1005             


Val Val  Leu Leu Leu Pro His  Gly His Glu Gly Gln  Gly Pro Asp 
    1010                 1015                 1020             


His Thr  Ser Ala Arg Ile Glu  Arg Phe Leu Gln Leu  Trp Ala Glu 
    1025                 1030                 1035             


Gly Ser  Met Thr Ile Ala Met  Pro Ser Thr Pro Ser  Asn Tyr Phe 
    1040                 1045                 1050             


His Leu  Leu Arg Arg His Ala  Leu Asp Gly Ile Gln  Arg Pro Leu 
    1055                 1060                 1065             


Ile Val  Phe Thr Pro Lys Ser  Met Leu Arg His Lys  Ala Ala Val 
    1070                 1075                 1080             


Ser Glu  Ile Lys Asp Phe Thr  Glu Ile Lys Phe Arg  Ser Val Leu 
    1085                 1090                 1095             


Glu Glu  Pro Thr Tyr Glu Asp  Gly Ile Gly Asp Arg  Asn Lys Val 
    1100                 1105                 1110             


Ser Arg  Ile Leu Leu Thr Ser  Gly Lys Leu Tyr Tyr  Glu Leu Ala 
    1115                 1120                 1125             


Ala Arg  Lys Ala Lys Asp Asn  Arg Asn Asp Leu Ala  Ile Val Arg 
    1130                 1135                 1140             


Leu Glu  Gln Leu Ala Pro Leu  Pro Arg Arg Arg Leu  Arg Glu Thr 
    1145                 1150                 1155             


Leu Asp  Arg Tyr Glu Asn Val  Lys Glu Phe Phe Trp  Val Gln Glu 
    1160                 1165                 1170             


Glu Pro  Ala Asn Gln Gly Ala  Trp Pro Arg Phe Gly  Leu Glu Leu 
    1175                 1180                 1185             


Pro Glu  Leu Leu Pro Asp Lys  Leu Ala Gly Ile Lys  Arg Ile Ser 
    1190                 1195                 1200             


Arg Arg  Ala Met Ser Ala Pro  Ser Ser Gly Ser Ser  Lys Val His 
    1205                 1210                 1215             


Ala Val  Glu Gln Gln Glu Ile  Leu Asp Glu Ala Phe  Gly 
    1220                 1225                 1230     


<210>  42
<211>  580
<212>  PRT
<213>  Bacillus subtilis

<400>  42

Met Thr Val Asn Pro Ile Thr His Tyr Ile Gly Ser Phe Ile Asp Glu 
1               5                   10                  15      


Phe Ala Leu Ser Gly Ile Thr Asp Ala Val Val Cys Pro Gly Ser Arg 
            20                  25                  30          


Ser Thr Pro Leu Ala Val Leu Cys Ala Ala His Pro Asp Ile Ser Val 
        35                  40                  45              


His Val Gln Ile Asp Glu Arg Ser Ala Gly Phe Phe Ala Leu Gly Leu 
    50                  55                  60                  


Ala Lys Ala Lys Gln Arg Pro Val Leu Leu Ile Cys Thr Ser Gly Thr 
65                  70                  75                  80  


Ala Ala Ala Asn Phe Tyr Pro Ala Val Val Glu Ala His Tyr Ser Arg 
                85                  90                  95      


Val Pro Ile Ile Val Leu Thr Ala Asp Arg Pro His Glu Leu Arg Glu 
            100                 105                 110         


Val Gly Ala Pro Gln Ala Ile Asn Gln His Phe Leu Phe Gly Asn Phe 
        115                 120                 125             


Val Lys Phe Phe Thr Asp Ser Ala Leu Pro Glu Glu Ser Pro Gln Met 
    130                 135                 140                 


Leu Arg Tyr Ile Arg Thr Leu Ala Ser Arg Ala Ala Gly Glu Ala Gln 
145                 150                 155                 160 


Lys Arg Pro Met Gly Pro Val His Val Asn Val Pro Leu Arg Glu Pro 
                165                 170                 175     


Leu Met Pro Asp Leu Ser Asp Glu Pro Phe Gly Arg Met Arg Thr Gly 
            180                 185                 190         


Arg His Val Ser Val Lys Thr Gly Thr Gln Ser Val Asp Arg Glu Ser 
        195                 200                 205             


Leu Ser Asp Val Ala Glu Met Leu Ala Glu Ala Glu Lys Gly Met Ile 
    210                 215                 220                 


Val Cys Gly Glu Leu His Ser Asp Ala Asp Lys Glu Asn Ile Ile Ala 
225                 230                 235                 240 


Leu Ser Lys Ala Leu Gln Tyr Pro Ile Leu Ala Asp Pro Leu Ser Asn 
                245                 250                 255     


Leu Arg Asn Gly Val His Asp Lys Ser Thr Val Ile Asp Ala Tyr Asp 
            260                 265                 270         


Ser Phe Leu Lys Asp Asp Glu Leu Lys Arg Lys Leu Arg Pro Asp Val 
        275                 280                 285             


Val Ile Arg Phe Gly Pro Met Pro Val Ser Lys Pro Val Phe Leu Trp 
    290                 295                 300                 


Leu Lys Asp Asp Pro Thr Ile Gln Gln Ile Val Ile Asp Glu Asp Gly 
305                 310                 315                 320 


Gly Trp Arg Asp Pro Thr Gln Ala Ser Ala His Met Ile His Cys Asn 
                325                 330                 335     


Ala Ser Val Phe Ala Glu Glu Ile Met Ala Gly Leu Thr Ala Ala Thr 
            340                 345                 350         


Arg Ser Ser Glu Trp Leu Glu Lys Trp Gln Phe Val Asn Gly Arg Phe 
        355                 360                 365             


Arg Glu His Leu Gln Thr Ile Ser Ser Glu Asp Val Ser Phe Glu Gly 
    370                 375                 380                 


Asn Leu Tyr Arg Ile Leu Gln His Leu Val Pro Glu Asn Ser Ser Leu 
385                 390                 395                 400 


Phe Val Gly Asn Ser Met Pro Ile Arg Asp Val Asp Thr Phe Phe Glu 
                405                 410                 415     


Lys Gln Asp Arg Pro Phe Arg Ile Tyr Ser Asn Arg Gly Ala Asn Gly 
            420                 425                 430         


Ile Asp Gly Val Val Ser Ser Ala Met Gly Val Cys Glu Gly Thr Lys 
        435                 440                 445             


Ala Pro Val Thr Leu Val Ile Gly Asp Leu Ser Phe Tyr His Asp Leu 
    450                 455                 460                 


Asn Gly Leu Leu Ala Ala Lys Lys Leu Gly Ile Pro Leu Thr Val Ile 
465                 470                 475                 480 


Leu Val Asn Asn Asp Gly Gly Gly Ile Phe Ser Phe Leu Pro Gln Ala 
                485                 490                 495     


Ser Glu Lys Thr His Phe Glu Asp Leu Phe Gly Thr Pro Thr Gly Leu 
            500                 505                 510         


Asp Phe Lys His Ala Ala Ala Leu Tyr Gly Gly Thr Tyr Ser Cys Pro 
        515                 520                 525             


Ala Ser Trp Asp Glu Phe Lys Thr Ala Tyr Ala Pro Gln Ala Asp Lys 
    530                 535                 540                 


Pro Gly Leu His Leu Ile Glu Ile Lys Thr Asp Arg Gln Ser Arg Val 
545                 550                 555                 560 


Gln Leu His Arg Asp Met Leu Asn Glu Ala Val Arg Glu Val Lys Lys 
                565                 570                 575     


Gln Trp Glu Leu 
            580 


<210>  43
<211>  426
<212>  PRT
<213>  Escherichia coli

<400>  43

Met Asn Ser Asn Lys Glu Leu Met Gln Arg Arg Ser Gln Ala Ile Pro 
1               5                   10                  15      


Arg Gly Val Gly Gln Ile His Pro Ile Phe Ala Asp Arg Ala Glu Asn 
            20                  25                  30          


Cys Arg Val Trp Asp Val Glu Gly Arg Glu Tyr Leu Asp Phe Ala Gly 
        35                  40                  45              


Gly Ile Ala Val Leu Asn Thr Gly His Leu His Pro Lys Val Val Ala 
    50                  55                  60                  


Ala Val Glu Ala Gln Leu Lys Lys Leu Ser His Thr Cys Phe Gln Val 
65                  70                  75                  80  


Leu Ala Tyr Glu Pro Tyr Leu Glu Leu Cys Glu Ile Met Asn Gln Lys 
                85                  90                  95      


Val Pro Gly Asp Phe Ala Lys Lys Thr Leu Leu Val Thr Thr Gly Ser 
            100                 105                 110         


Glu Ala Val Glu Asn Ala Val Lys Ile Ala Arg Ala Ala Thr Lys Arg 
        115                 120                 125             


Ser Gly Thr Ile Ala Phe Ser Gly Ala Tyr His Gly Arg Thr His Tyr 
    130                 135                 140                 


Thr Leu Ala Leu Thr Gly Lys Val Asn Pro Tyr Ser Ala Gly Met Gly 
145                 150                 155                 160 


Leu Met Pro Gly His Val Tyr Arg Ala Leu Tyr Pro Cys Pro Leu His 
                165                 170                 175     


Gly Ile Ser Glu Asp Asp Ala Ile Ala Ser Ile His Arg Ile Phe Lys 
            180                 185                 190         


Asn Asp Ala Ala Pro Glu Asp Ile Ala Ala Ile Val Ile Glu Pro Val 
        195                 200                 205             


Gln Gly Glu Gly Gly Phe Tyr Ala Ser Ser Pro Ala Phe Met Gln Arg 
    210                 215                 220                 


Leu Arg Ala Leu Cys Asp Glu His Gly Ile Met Leu Ile Ala Asp Glu 
225                 230                 235                 240 


Val Gln Ser Gly Ala Gly Arg Thr Gly Thr Leu Phe Ala Met Glu Gln 
                245                 250                 255     


Met Gly Val Ala Pro Asp Leu Thr Thr Phe Ala Lys Ser Ile Ala Gly 
            260                 265                 270         


Gly Phe Pro Leu Ala Gly Val Thr Gly Arg Ala Glu Val Met Asp Ala 
        275                 280                 285             


Val Ala Pro Gly Gly Leu Gly Gly Thr Tyr Ala Gly Asn Pro Ile Ala 
    290                 295                 300                 


Cys Val Ala Ala Leu Glu Val Leu Lys Val Phe Glu Gln Glu Asn Leu 
305                 310                 315                 320 


Leu Gln Lys Ala Asn Asp Leu Gly Gln Lys Leu Lys Asp Gly Leu Leu 
                325                 330                 335     


Ala Ile Ala Glu Lys His Pro Glu Ile Gly Asp Val Arg Gly Leu Gly 
            340                 345                 350         


Ala Met Ile Ala Ile Glu Leu Phe Glu Asp Gly Asp His Asn Lys Pro 
        355                 360                 365             


Asp Ala Lys Leu Thr Ala Glu Ile Val Ala Arg Ala Arg Asp Lys Gly 
    370                 375                 380                 


Leu Ile Leu Leu Ser Cys Gly Pro Tyr Tyr Asn Val Leu Arg Ile Leu 
385                 390                 395                 400 


Val Pro Leu Thr Ile Glu Asp Ala Gln Ile Arg Gln Gly Leu Glu Ile 
                405                 410                 415     


Ile Ser Gln Cys Phe Asp Glu Ala Lys Gln 
            420                 425     


<210>  44
<211>  504
<212>  PRT
<213>  Arabidopsis thaliana

<400>  44

Met Val Val Ile Asn Ser Leu Arg Arg Leu Ala Arg Thr Thr Gln Val 
1               5                   10                  15      


His Leu His Ser Lys Tyr Ala Thr Cys Met Ser Gly Asn Ser Thr Ser 
            20                  25                  30          


Arg Arg Ile Phe Thr Thr Glu Ala Ala Pro Glu Lys Lys Asn Thr Val 
        35                  40                  45              


Gly Ser Lys Gly His Asp Met Leu Ala Pro Phe Thr Ala Gly Trp Gln 
    50                  55                  60                  


Ser Ala Asp Leu Asp Pro Leu Val Ile Ala Lys Ser Glu Gly Ser Tyr 
65                  70                  75                  80  


Val Tyr Asp Asp Thr Gly Lys Lys Tyr Leu Asp Ser Leu Ala Gly Leu 
                85                  90                  95      


Trp Cys Thr Ala Leu Gly Gly Asn Glu Pro Arg Leu Val Ser Ala Ala 
            100                 105                 110         


Val Glu Gln Leu Asn Thr Leu Pro Phe Tyr His Ser Phe Trp Asn Arg 
        115                 120                 125             


Thr Thr Lys Pro Ser Leu Asp Leu Ala Lys Val Leu Leu Glu Met Phe 
    130                 135                 140                 


Thr Ala Asn Lys Met Ala Lys Ala Phe Phe Thr Ser Gly Gly Ser Asp 
145                 150                 155                 160 


Ala Asn Asp Thr Gln Val Lys Leu Val Trp Tyr Tyr Asn Asn Ala Leu 
                165                 170                 175     


Gly Arg Pro Glu Lys Lys Lys Phe Ile Ala Arg Lys Lys Ser Tyr His 
            180                 185                 190         


Gly Ser Thr Leu Ile Ser Ala Ser Leu Ser Gly Leu Pro Pro Leu His 
        195                 200                 205             


Gln Asn Phe Asp Leu Pro Ala Pro Phe Val Leu His Thr Asp Cys Pro 
    210                 215                 220                 


His Tyr Trp Arg Phe His Leu Pro Gly Glu Thr Glu Glu Glu Phe Ser 
225                 230                 235                 240 


Thr Arg Leu Ala Lys Asn Leu Glu Asp Leu Ile Ile Lys Glu Gly Pro 
                245                 250                 255     


Glu Thr Ile Gly Ala Phe Ile Ala Glu Pro Val Met Gly Ala Gly Gly 
            260                 265                 270         


Val Ile Pro Pro Pro Ala Thr Tyr Phe Glu Lys Val Gln Ala Val Val 
        275                 280                 285             


Lys Lys Tyr Asp Ile Leu Phe Ile Ala Asp Glu Val Ile Cys Ala Phe 
    290                 295                 300                 


Gly Arg Leu Gly Thr Met Phe Gly Cys Asp Lys Tyr Asn Ile Lys Pro 
305                 310                 315                 320 


Asp Leu Val Thr Leu Ala Lys Ala Leu Ser Ser Ala Tyr Met Pro Ile 
                325                 330                 335     


Gly Ala Ile Leu Met Ser Gln Glu Val Ala Asp Val Ile Asn Ser His 
            340                 345                 350         


Ser Ser Lys Leu Gly Val Phe Ser His Gly Phe Thr Tyr Ser Gly His 
        355                 360                 365             


Pro Val Ser Cys Ala Val Ala Ile Glu Ala Leu Lys Ile Tyr Lys Glu 
    370                 375                 380                 


Arg Asn Ile Pro Glu Tyr Val Ala Lys Val Ala Pro Arg Phe Gln Asp 
385                 390                 395                 400 


Gly Val Lys Ala Phe Ala Ser Gly Ser Pro Ile Ile Gly Glu Thr Arg 
                405                 410                 415     


Gly Thr Gly Leu Ile Leu Gly Thr Glu Phe Val Asp Asn Lys Ser Pro 
            420                 425                 430         


Asn Glu Pro Phe Pro Pro Glu Trp Gly Val Gly Ala Phe Phe Gly Ala 
        435                 440                 445             


Glu Cys Gln Lys His Gly Met Leu Val Arg Val Ala Gly Asp Gly Ile 
    450                 455                 460                 


Leu Met Ser Pro Pro Leu Ile Ile Ser Pro Glu Glu Ile Asp Glu Leu 
465                 470                 475                 480 


Ile Ser Ile Tyr Gly Lys Ala Leu Lys Ala Thr Glu Glu Lys Val Lys 
                485                 490                 495     


Glu Leu Lys Ala Gln His Lys Lys 
            500                 


<210>  45
<211>  515
<212>  PRT
<213>  Solanum lycopersicum

<400>  45

Met Ala Lys Ile Ser Arg Leu Phe Gly Ser Thr Val Lys Ala Ala Ile 
1               5                   10                  15      


Thr Ala Gln Ala Gly Phe His Gly Lys Arg Ile Pro Ala Val Ser Ser 
            20                  25                  30          


Leu Gln Glu His Ile Val Lys Ser Thr Pro Ala Arg Tyr Asn Ser Thr 
        35                  40                  45              


Gln Ala Cys Leu Glu Asn Asp Ile Ser Gly Thr Asp Asn Lys Gly Phe 
    50                  55                  60                  


Lys Gly His Asp Met Leu Ala Pro Phe Thr Ala Gly Trp Gln Ser Thr 
65                  70                  75                  80  


Asp Val Asp Pro Leu Ile Ile Glu Lys Ser Glu Gly Ser His Val Tyr 
                85                  90                  95      


Asp Met Gln Gly Arg Lys Tyr Ile Asp Thr Leu Ala Gly Leu Trp Cys 
            100                 105                 110         


Thr Ala Leu Gly Gly Asn Glu Pro Arg Leu Val Asp Ala Ala Thr Lys 
        115                 120                 125             


Gln Leu Asn Thr Leu Pro Phe Tyr His Ser Phe Trp Asn Arg Thr Thr 
    130                 135                 140                 


Lys Pro Ser Leu Asp Leu Ala Lys Glu Leu Leu Asp Met Phe Thr Ala 
145                 150                 155                 160 


Lys Lys Met Ala Lys Ala Phe Phe Thr Asn Ser Gly Ser Glu Ala Asn 
                165                 170                 175     


Asp Thr Gln Val Lys Leu Val Trp Tyr Tyr Asn Asn Ala Leu Gly Arg 
            180                 185                 190         


Pro Asn Lys Lys Lys Phe Ile Ala Arg Ala Lys Ala Tyr His Gly Ser 
        195                 200                 205             


Thr Leu Ile Ser Ala Ser Leu Thr Gly Leu Pro Ala Leu His Gln Asn 
    210                 215                 220                 


Phe Asp Leu Pro Ala Pro Phe Val Leu His Thr Asp Cys Pro His Tyr 
225                 230                 235                 240 


Trp Arg Tyr His Leu Pro Gly Glu Thr Glu Glu Glu Phe Ser Thr Arg 
                245                 250                 255     


Leu Ala Lys Asn Leu Glu Asp Leu Ile Leu Lys Glu Gly Pro Glu Thr 
            260                 265                 270         


Ile Ala Ala Phe Ile Ala Glu Pro Val Met Gly Ala Gly Gly Val Ile 
        275                 280                 285             


Pro Pro Pro Ala Thr Tyr Phe Asp Lys Ile Gln Ala Val Val Lys Lys 
    290                 295                 300                 


Tyr Asp Ile Leu Phe Ile Ala Asp Glu Val Ile Cys Ala Phe Gly Arg 
305                 310                 315                 320 


Leu Gly Thr Met Phe Gly Ser Asp Met Tyr Asn Ile Lys Pro Asp Leu 
                325                 330                 335     


Val Thr Leu Ala Lys Ala Leu Ser Ser Ala Tyr Met Pro Ile Gly Ala 
            340                 345                 350         


Val Leu Val Ser Pro Glu Val Ser Asp Val Ile His Ser Gln Ser Asn 
        355                 360                 365             


Lys Leu Gly Ser Phe Ser His Gly Phe Thr Tyr Ser Gly His Pro Val 
    370                 375                 380                 


Ala Cys Ala Val Ala Leu Glu Ala Ile Lys Ile Tyr Lys Glu Arg Asn 
385                 390                 395                 400 


Met Val Glu Arg Val Asn Arg Ile Ser Pro Lys Phe Gln Glu Gly Leu 
                405                 410                 415     


Lys Ala Phe Ser Asp Ser Pro Ile Ile Gly Glu Ile Arg Gly Leu Gly 
            420                 425                 430         


Leu Ile Leu Ala Thr Glu Phe Ala Asn Asn Lys Ser Pro Asn Asp His 
        435                 440                 445             


Phe Pro Pro Glu Trp Gly Val Gly Ala Tyr Phe Gly Ala Gln Cys Gln 
    450                 455                 460                 


Lys Asn Gly Met Leu Val Arg Val Ala Gly Asp Thr Ile Met Met Ser 
465                 470                 475                 480 


Pro Pro Phe Val Val Thr Pro Glu Glu Leu Asp Glu Leu Ile Arg Ile 
                485                 490                 495     


Tyr Gly Lys Ala Leu Arg Glu Thr Glu Lys Arg Val Glu Glu Leu Lys 
            500                 505                 510         


Ser Gln Lys 
        515 


<210>  46
<211>  520
<212>  PRT
<213>  Solanum lycopersicum

<400>  46

Met Ala Lys Ile Thr Ser Leu Ile Gly Ser Gly Ile Val Ala Ala Thr 
1               5                   10                  15      


Asn Gln Val Gly Pro His Val Lys His Ile Pro Ala Val Gly Asn Leu 
            20                  25                  30          


Gln Lys Gln Ile Val Ser Asp Gln Ile Gln Val Arg Trp Ser Ser Thr 
        35                  40                  45              


Glu Thr Ser Leu Lys Asn Asp Ile Ser Ala Thr Asp Val Arg Gly Tyr 
    50                  55                  60                  


Lys Gly His Asp Met Leu Ala Pro Phe Thr Ala Gly Trp His Ser Thr 
65                  70                  75                  80  


Asp Leu Glu Pro Leu Val Ile Gln Lys Ser Glu Gly Ser Tyr Val Tyr 
                85                  90                  95      


Asp Val Asn Gly Lys Lys Tyr Leu Asp Ala Leu Ala Gly Leu Trp Cys 
            100                 105                 110         


Thr Ser Leu Gly Gly Asn Glu Pro Arg Leu Val Ala Ala Ala Thr Lys 
        115                 120                 125             


Gln Leu Asn Glu Leu Ala Phe Tyr His Ser Phe Trp Asn Arg Ser Thr 
    130                 135                 140                 


Lys Pro Ser Leu Asp Leu Ala Lys Glu Leu Leu Asp Leu Phe Thr Ala 
145                 150                 155                 160 


Asn Lys Met Ala Lys Ala Phe Phe Thr Asn Ser Gly Ser Glu Ala Asn 
                165                 170                 175     


Asp Thr Gln Val Lys Leu Val Trp Tyr Tyr Asn Asn Ala Leu Gly Arg 
            180                 185                 190         


Pro Asp Lys Lys Lys Phe Ile Ala Arg Thr Lys Ser Tyr His Gly Ser 
        195                 200                 205             


Thr Leu Ile Ser Ala Ser Leu Ser Gly Leu Pro Ala Leu His Gln Gln 
    210                 215                 220                 


Phe Asp Leu Pro Ala Pro Phe Val Leu His Thr Asp Cys Pro His Phe 
225                 230                 235                 240 


Trp Arg Phe His Gln Pro Gly Glu Thr Glu Glu Glu Phe Ser Thr Arg 
                245                 250                 255     


Leu Ala Asn Asn Leu Glu Asn Leu Ile Leu Lys Glu Gly Pro Glu Thr 
            260                 265                 270         


Ile Ala Ala Phe Ile Ala Glu Pro Val Met Gly Ala Gly Gly Val Ile 
        275                 280                 285             


Pro Pro Pro Ala Thr Tyr Phe Glu Lys Val Gln Ala Ile Leu Lys Lys 
    290                 295                 300                 


Tyr Asp Ile Leu Phe Ile Ala Asp Glu Val Ile Cys Gly Phe Gly Arg 
305                 310                 315                 320 


Leu Gly Thr Met Phe Gly Cys Glu Lys Tyr Asn Ile Lys Pro Asp Leu 
                325                 330                 335     


Val Ser Val Ala Lys Ala Leu Ser Ser Gly Tyr Met Pro Ile Gly Ala 
            340                 345                 350         


Val Leu Val Ser Pro Glu Val Ser Asp Val Ile Tyr Ser Gln Ser Asn 
        355                 360                 365             


Lys Leu Gly Thr Phe Ser His Gly Phe Thr Tyr Ser Gly His Pro Val 
    370                 375                 380                 


Ser Cys Ala Val Ala Leu Glu Thr Leu Lys Ile Tyr Lys Glu Arg Asn 
385                 390                 395                 400 


Ile Ile Glu Gln Val Asn Arg Ile Ser Pro Lys Phe Gln Glu Gly Leu 
                405                 410                 415     


Lys Ala Phe Ser Asp Ser Pro Ile Ile Gly Glu Ile Arg Gly Thr Gly 
            420                 425                 430         


Leu Leu His Gly Thr Glu Phe Thr Asp Asn Lys Ser Pro Asn Asp Pro 
        435                 440                 445             


Phe Pro Pro Glu Trp Gly Ile Gly Ala Tyr Phe Gly Ala Arg Cys Glu 
    450                 455                 460                 


Lys His Gly Val Leu Val Arg Val Ala Gly Asp Asn Ile Met Met Ser 
465                 470                 475                 480 


Pro Pro Tyr Ile Leu Ser Leu Glu Glu Ile Asp Glu Leu Ile Ile Lys 
                485                 490                 495     


Tyr Gly Lys Ala Leu Lys Asp Thr Glu Asn Arg Val Glu Glu Leu Lys 
            500                 505                 510         


Ser Gln Lys Lys Ile Lys Ser Ser 
        515                 520 


<210>  47
<211>  458
<212>  PRT
<213>  Solanum lycopersicum

<400>  47

Met Ala Lys Thr Asn Gly Phe Met Gly His Asp Met Leu Ala Pro Phe 
1               5                   10                  15      


Thr Ala Ala Trp Met Ile Asp Met Gly Pro Leu Val Ile Asp Lys Ala 
            20                  25                  30          


Glu Gly Ser Tyr Val Tyr Gly Val Asn Gly Lys Lys Tyr Leu Asp Ser 
        35                  40                  45              


Leu Ser Gly Leu Trp Cys Thr Val Leu Gly Gly Ser Glu Pro Arg Leu 
    50                  55                  60                  


Ile Glu Ala Ala Ser Lys Gln Leu Asn Lys Ser Ala Phe Tyr His Ser 
65                  70                  75                  80  


Phe Trp Asn Arg Thr Thr Lys Pro Ser Leu Asp Leu Ala Lys Glu Leu 
                85                  90                  95      


Ile Asn Met Phe Thr Ala Asn Lys Met Gly Lys Val Phe Phe Thr Ser 
            100                 105                 110         


Ser Gly Ser Glu Ala Asn Asp Thr Gln Val Lys Leu Val Trp Tyr Tyr 
        115                 120                 125             


Asn Asn Ala Ile Gly Arg Pro Asn Lys Lys Lys Ile Ile Ser Arg Lys 
    130                 135                 140                 


Asn Ala Tyr His Gly Ser Thr Tyr Met Thr Ala Gly Leu Ser Gly Leu 
145                 150                 155                 160 


Pro Ser Leu His Leu Lys Phe Asp Leu Pro Pro Pro Tyr Ile Leu His 
                165                 170                 175     


Thr Asp Cys Pro His Tyr Trp Asn Tyr His Leu Pro Gly Glu Thr Glu 
            180                 185                 190         


Glu Glu Tyr Ser Thr Arg Leu Ala Asn Asn Leu Glu Asn Leu Ile Leu 
        195                 200                 205             


Lys Glu Gly Pro Glu Thr Val Ala Ala Phe Ile Ala Glu Pro Val Met 
    210                 215                 220                 


Gly Gly Ala Gly Val Ile Ile Pro Pro Ala Thr Tyr Phe Glu Lys Ile 
225                 230                 235                 240 


Gln Ala Val Leu Lys Lys Tyr Asp Ile Leu Phe Ile Ala Asp Glu Val 
                245                 250                 255     


Ile Cys Gly Phe Gly Arg Leu Gly Thr Met Phe Gly Cys Asp Lys Tyr 
            260                 265                 270         


Asn Ile Lys Pro Asp Leu Val Ser Ile Ala Lys Ala Leu Ser Gly Gly 
        275                 280                 285             


Tyr Ile Pro Ile Gly Ala Val Leu Val Ser Glu Glu Ile Ser Lys Val 
    290                 295                 300                 


Ile Met Ser Gln Ser Asn Gln Leu Gly Val Phe Cys His Gly Phe Thr 
305                 310                 315                 320 


Tyr Ser Gly His Pro Val Ala Cys Ala Val Ala Leu Glu Ala Leu Lys 
                325                 330                 335     


Ile Tyr Lys Glu Lys Asn Ile Thr Glu Val Val Asn Lys Leu Ser Pro 
            340                 345                 350         


Lys Leu Gln Glu Gly Leu Lys Ala Phe Ile Asp Ser Pro Ile Ile Gly 
        355                 360                 365             


Glu Ile Arg Gly Thr Gly Leu Val Leu Ser Thr Glu Phe Val Asp Asn 
    370                 375                 380                 


Lys Ser Pro Asn Asp Pro Phe Pro Pro Glu Trp Gly Val Gly Thr Tyr 
385                 390                 395                 400 


Phe Gly Ser Gln Cys Gln Lys His Gly Met Leu Val Ser Phe Ser Gly 
                405                 410                 415     


Asp His Val Asn Met Ala Pro Pro Phe Thr Leu Ser Leu Glu Glu Leu 
            420                 425                 430         


Asp Glu Met Ile Ser Ile Tyr Gly Lys Ala Leu Lys Asp Thr Glu Lys 
        435                 440                 445             


Arg Val Glu Glu Leu Lys Ser Gln Lys Lys 
    450                 455             


<210>  48
<211>  448
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  48

Met Asn Gln Pro Leu Asn Val Ala Pro Pro Val Ser Ser Glu Leu Asn 
1               5                   10                  15      


Leu Arg Ala His Trp Met Pro Phe Ser Ala Asn Arg Asn Phe Gln Lys 
            20                  25                  30          


Asp Pro Arg Ile Ile Val Ala Ala Glu Gly Ser Trp Leu Thr Asp Asp 
        35                  40                  45              


Lys Gly Arg Lys Val Tyr Asp Ser Leu Ser Gly Leu Trp Thr Cys Gly 
    50                  55                  60                  


Ala Gly His Ser Arg Lys Glu Ile Gln Glu Ala Val Ala Arg Gln Leu 
65                  70                  75                  80  


Gly Thr Leu Asp Tyr Ser Pro Gly Phe Gln Tyr Gly His Pro Leu Ser 
                85                  90                  95      


Phe Gln Leu Ala Glu Lys Ile Ala Gly Leu Leu Pro Gly Glu Leu Asn 
            100                 105                 110         


His Val Phe Phe Thr Gly Ser Gly Ser Glu Cys Ala Asp Thr Ser Ile 
        115                 120                 125             


Lys Met Ala Arg Ala Tyr Trp Arg Leu Lys Gly Gln Pro Gln Lys Thr 
    130                 135                 140                 


Lys Leu Ile Gly Arg Ala Arg Gly Tyr His Gly Val Asn Val Ala Gly 
145                 150                 155                 160 


Thr Ser Leu Gly Gly Ile Gly Gly Asn Arg Lys Met Phe Gly Gln Leu 
                165                 170                 175     


Met Asp Val Asp His Leu Pro His Thr Leu Gln Pro Gly Met Ala Phe 
            180                 185                 190         


Thr Arg Gly Met Ala Gln Thr Gly Gly Val Glu Leu Ala Asn Glu Leu 
        195                 200                 205             


Leu Lys Leu Ile Glu Leu His Asp Ala Ser Asn Ile Ala Ala Val Ile 
    210                 215                 220                 


Val Glu Pro Met Ser Gly Ser Ala Gly Val Leu Val Pro Pro Val Gly 
225                 230                 235                 240 


Tyr Leu Gln Arg Leu Arg Glu Ile Cys Asp Gln His Asn Ile Leu Leu 
                245                 250                 255     


Ile Phe Asp Glu Val Ile Thr Ala Phe Gly Arg Leu Gly Thr Tyr Ser 
            260                 265                 270         


Gly Ala Glu Tyr Phe Gly Val Thr Pro Asp Leu Met Asn Val Ala Lys 
        275                 280                 285             


Gln Val Thr Asn Gly Ala Val Pro Met Gly Ala Val Ile Ala Ser Ser 
    290                 295                 300                 


Glu Ile Tyr Asp Thr Phe Met Asn Gln Ala Leu Pro Glu His Ala Val 
305                 310                 315                 320 


Glu Phe Ser His Gly Tyr Thr Tyr Ser Ala His Pro Val Ala Cys Ala 
                325                 330                 335     


Ala Gly Leu Ala Ala Leu Asp Ile Leu Ala Arg Asp Asn Leu Val Gln 
            340                 345                 350         


Gln Ser Ala Glu Leu Ala Pro His Phe Glu Lys Gly Leu His Gly Leu 
        355                 360                 365             


Gln Gly Ala Lys Asn Val Ile Asp Ile Arg Asn Cys Gly Leu Ala Gly 
    370                 375                 380                 


Ala Ile Gln Ile Ala Pro Arg Asp Gly Asp Pro Thr Val Arg Pro Phe 
385                 390                 395                 400 


Glu Ala Gly Met Lys Leu Trp Gln Gln Gly Phe Tyr Val Arg Phe Gly 
                405                 410                 415     


Gly Asp Thr Leu Gln Phe Gly Pro Thr Phe Asn Ala Arg Pro Glu Glu 
            420                 425                 430         


Leu Asp Arg Leu Phe Asp Ala Val Gly Glu Ala Leu Asn Gly Ile Ala 
        435                 440                 445             


<210>  49
<211>  483
<212>  PRT
<213>  Oryza sativa subsp. japonica

<400>  49

Met Thr Thr Pro His Gly Leu Leu Gln Tyr Ser Ser Gly Ala Phe Ser 
1               5                   10                  15      


Asp Gln Val Pro Ala Asp Asp Ser Ala Glu Glu His Gly Val Lys Asp 
            20                  25                  30          


His Ala Met Leu Ala Pro Phe Thr Ala Ala Trp Gln Thr Ala Ile Ser 
        35                  40                  45              


Pro Pro Leu Val Ile Glu Arg Ser Glu Gly Cys Tyr Val Tyr Asp Val 
    50                  55                  60                  


Asn Gly Thr Lys Tyr Leu Asp Ala Leu Ala Gly Leu Leu Ser Thr Ala 
65                  70                  75                  80  


Leu Gly Gly Ser Glu Pro Arg Leu Val Lys Ala Ala Thr Glu Gln Leu 
                85                  90                  95      


Asn Lys Leu Pro Phe Tyr His Ser Phe Trp Asn His Thr Thr Arg Pro 
            100                 105                 110         


Ser Leu Asp Leu Ala Lys Glu Leu Ile Ser Met Phe Thr Ala Arg Glu 
        115                 120                 125             


Met Gly Lys Val Phe Phe Thr Asn Ser Gly Ser Glu Ala Asn Asp Ser 
    130                 135                 140                 


Gln Val Lys Ile Val Trp Tyr Tyr Asn Asn Ala Leu Gly Arg Pro Lys 
145                 150                 155                 160 


Lys Lys Asn Ile Ile Ser Arg Thr Gln Ser Tyr His Gly Thr Thr Phe 
                165                 170                 175     


Ile Ser Ala Ser Leu Ser Gly Leu Pro Thr Leu His Gln Asp Phe Asp 
            180                 185                 190         


Leu Pro Gly Arg Phe Val Leu His Thr Asp Cys Pro His Tyr Trp Arg 
        195                 200                 205             


Phe His Leu Pro Gly Glu Thr Glu Glu Glu Phe Ala Thr Arg Leu Ala 
    210                 215                 220                 


Asp Asn Leu Glu Asn Leu Ile Leu Lys Gln Gly Pro Glu Thr Ile Ala 
225                 230                 235                 240 


Ala Phe Ile Ala Glu Pro Val Ile Gly Ala Gly Gly Val Ile Leu Pro 
                245                 250                 255     


Pro Lys Thr Tyr Phe Glu Lys Ile Gln Ala Val Val Lys Lys Tyr Asp 
            260                 265                 270         


Ile Leu Phe Ile Val Asp Glu Val Ile Thr Gly Phe Gly Arg Leu Gly 
        275                 280                 285             


Thr Met Phe Gly Ser Asp Leu Tyr Asn Ile Lys Pro Asp Leu Val Ser 
    290                 295                 300                 


Leu Ala Lys Ala Leu Ser Ser Ala Tyr Ala Pro Ile Gly Ala Ile Leu 
305                 310                 315                 320 


Val Ser Pro Glu Ile Ser Asp Val Ile His Ser His Ser Asn Lys Leu 
                325                 330                 335     


Gly Thr Phe Ala His Gly Phe Thr Tyr Ser Gly His Pro Val Ser Cys 
            340                 345                 350         


Ala Val Ala Leu Glu Ala Leu Lys Ile Tyr Arg Glu Arg Asp Ile Pro 
        355                 360                 365             


Gly His Val Thr His Val Ala Gln Arg Phe Gln Glu Gly Ile Lys Ala 
    370                 375                 380                 


Phe Ala Ala Gly Ser Pro Ile Val Gly Glu Thr Arg Gly Val Gly Leu 
385                 390                 395                 400 


Leu Ile Ala Thr Glu Phe Thr Asp Asn Lys Ser Pro Tyr Glu Leu Phe 
                405                 410                 415     


Pro Phe Glu Trp Gly Val Gly Glu Ile Phe Gly Gln Glu Cys Lys Lys 
            420                 425                 430         


Arg Gly Met Met Val Lys Val Leu Gly Asn Leu Ile Ala Met Ser Pro 
        435                 440                 445             


Pro Leu Ile Ile Thr Arg Glu Glu Ile Asp Lys Leu Val Ser Ile Tyr 
    450                 455                 460                 


Gly Glu Ala Leu Lys Ala Thr Glu Glu Arg Val Ala Glu Leu Lys Ser 
465                 470                 475                 480 


Lys Lys Asn 
            


<210>  50
<211>  516
<212>  PRT
<213>  Oryza sativa subsp. japonica

<400>  50

Met Val Ile Ala Arg Gly Leu Leu Arg Ser Asn Ala Ser Ser Ser Ser 
1               5                   10                  15      


Ser Gln Ala Ile Asn Leu Leu Lys Tyr Val Thr Ser Thr Gly Ser Leu 
            20                  25                  30          


Gln Gly His Thr Gln Asn Leu Cys Asp Ala Ser Thr Arg His Phe Ser 
        35                  40                  45              


Ser Val Pro Ser Pro Gln Tyr Asn Ser Thr Glu Glu Asn Gly Phe Lys 
    50                  55                  60                  


Gly His Gly Met Leu Ala Pro Phe Thr Ala Gly Trp Gln Ser Thr Asp 
65                  70                  75                  80  


Val His Pro Leu Val Ile Glu Arg Ser Glu Gly Ser Tyr Val Tyr Asp 
                85                  90                  95      


Ile Asp Gly Lys Lys Tyr Leu Asp Ser Leu Ala Gly Leu Trp Cys Thr 
            100                 105                 110         


Ala Leu Gly Gly Ser Glu Pro Arg Leu Val Lys Ala Ala Thr Glu Gln 
        115                 120                 125             


Leu His Lys Leu Pro Phe Tyr His Ser Phe Trp Asn Arg Thr Thr Lys 
    130                 135                 140                 


Pro Ser Leu Asp Leu Ala Lys Glu Leu Leu Ser Met Phe Thr Ala Arg 
145                 150                 155                 160 


Glu Met Gly Lys Val Phe Phe Thr Asn Ser Gly Ser Glu Ala Asn Asp 
                165                 170                 175     


Ser Gln Val Lys Leu Val Trp Tyr Tyr Asn Asn Ala Leu Gly Arg Pro 
            180                 185                 190         


Asp Lys Lys Lys Phe Ile Ala Arg Ser Lys Ser Tyr His Gly Ser Thr 
        195                 200                 205             


Leu Ile Ser Ala Ser Leu Ser Gly Leu Pro Ala Leu His Gln Lys Phe 
    210                 215                 220                 


Asp Leu Pro Ala Pro Phe Val Leu His Thr Asp Cys Pro His Tyr Trp 
225                 230                 235                 240 


Arg Phe His Leu Pro Gly Glu Thr Glu Glu Glu Phe Ala Thr Arg Leu 
                245                 250                 255     


Ala Asn Asn Leu Glu Glu Leu Ile Leu Lys Glu Gly Pro Glu Thr Ile 
            260                 265                 270         


Ala Ala Phe Ile Ala Glu Pro Val Met Gly Ala Gly Gly Val Ile Pro 
        275                 280                 285             


Pro Pro Lys Thr Tyr Phe Glu Lys Val Gln Ala Ile Val Lys Lys Tyr 
    290                 295                 300                 


Asp Ile Leu Phe Ile Ala Asp Glu Val Ile Thr Ala Phe Gly Arg Leu 
305                 310                 315                 320 


Gly Thr Met Phe Gly Ser Asp Met Tyr Asn Ile Lys Pro Asp Leu Val 
                325                 330                 335     


Ser Met Ala Lys Ala Leu Ser Ser Ala Tyr Val Pro Ile Gly Ala Ile 
            340                 345                 350         


Met Val Ser Pro Glu Ile Ser Asp Val Ile His Ser Gln Ser Asn Lys 
        355                 360                 365             


Leu Gly Ser Phe Ala His Gly Phe Thr Tyr Ser Gly His Pro Val Ala 
    370                 375                 380                 


Cys Ala Val Ala Ile Glu Ala Leu Lys Ile Tyr Gln Glu Arg Asn Ile 
385                 390                 395                 400 


Pro Asp His Val Lys Gln Ile Ser Pro Arg Phe Gln Glu Gly Val Lys 
                405                 410                 415     


Ala Phe Ala Gly Ser Pro Ile Val Gly Glu Ile Arg Gly Val Gly Leu 
            420                 425                 430         


Ile Leu Gly Thr Glu Phe Ala Asp Asn Lys Ser Pro Asn Asp Pro Phe 
        435                 440                 445             


Pro Ala Glu Trp Gly Val Gly Ala Ile Phe Gly Ala Glu Cys Gln Lys 
    450                 455                 460                 


Arg Gly Met Leu Val Arg Val Ala Gly Asp Asn Ile Met Met Ser Pro 
465                 470                 475                 480 


Pro Leu Ile Met Thr Pro Asp Glu Val Glu Glu Leu Val Ser Ile Tyr 
                485                 490                 495     


Gly Asp Ala Leu Lys Ala Thr Glu Glu Arg Val Ala Glu Leu Lys Ser 
            500                 505                 510         


Lys Lys Asn Asn 
        515     


<210>  51
<211>  497
<212>  PRT
<213>  Oryza sativa subsp. japonica

<400>  51

Met Asn Leu Ile Lys His Ala Ala Phe Ala Ala Ser Phe Gln Gly Glu 
1               5                   10                  15      


Thr Asp Cys Thr Ser His Ala Ser Ala Arg Lys Phe Ser Thr Ser Gly 
            20                  25                  30          


Ser Ser Pro Leu Leu Asp Ser Thr Glu Gly Asn Gly Phe Lys Gly His 
        35                  40                  45              


Ser Met Leu Ala Pro Phe Thr Ala Gly Trp His Ser Thr Asp Leu Glu 
    50                  55                  60                  


Pro Leu Ile Ile Glu Arg Ser Glu Gly Ser Tyr Val Tyr Asp Ser Lys 
65                  70                  75                  80  


Gly Asn Lys Tyr Leu Asp Thr Leu Ala Gly Leu Trp Cys Thr Ala Leu 
                85                  90                  95      


Gly Gly Ser Glu Pro Arg Leu Val Lys Ala Ala Thr Asp Gln Leu Asn 
            100                 105                 110         


Lys Leu Pro Phe Tyr His Ser Phe Trp Asn Ser Thr Ala Lys Pro Pro 
        115                 120                 125             


Leu Asp Leu Ala Glu Glu Leu Ile Ser Met Phe Thr Ala Lys Glu Met 
    130                 135                 140                 


Gly Lys Val Phe Phe Thr Asn Ser Gly Ser Glu Ala Asn Asp Ser Gln 
145                 150                 155                 160 


Val Lys Leu Val Trp Tyr Tyr Asn Asn Ala Leu Gly Arg Pro Asn Lys 
                165                 170                 175     


Lys Lys Ile Ile Ala Gln Ser Gln Ala Tyr His Gly Ser Thr Leu Ile 
            180                 185                 190         


Ser Ala Ser Leu Ser Gly Leu Pro Ala Met His Leu Lys Phe Asp Leu 
        195                 200                 205             


Pro Ala Pro Phe Val Leu His Thr Asp Cys Pro His Tyr Trp Arg Phe 
    210                 215                 220                 


Gly Leu Pro Gly Glu Ala Glu Glu Glu Phe Ala Thr Arg Leu Ala Asp 
225                 230                 235                 240 


Asn Leu Glu Asn Leu Ile Leu Lys Glu Gly Pro Glu Thr Val Ala Ala 
                245                 250                 255     


Phe Ile Ala Glu Pro Val Ile Gly Ala Gly Gly Val Ile Pro Pro Pro 
            260                 265                 270         


Lys Thr Tyr Phe Glu Lys Ile Gln Ala Val Leu Gln Lys Tyr Asp Val 
        275                 280                 285             


Leu Phe Ile Ala Asp Glu Val Ile Thr Gly Phe Gly Arg Leu Gly Thr 
    290                 295                 300                 


Met Phe Gly Ser Asp Leu Tyr Asn Ile Lys Pro Asp Leu Val Ser Leu 
305                 310                 315                 320 


Ala Lys Ala Leu Ser Ser Ala Tyr Val Pro Ile Gly Ala Thr Leu Val 
                325                 330                 335     


Ser Pro Glu Ile Ser Asp Val Val His Ser Gln Ser Asn Lys Ile Gly 
            340                 345                 350         


Phe Phe Ala His Gly Phe Thr Tyr Ser Gly His Pro Val Ser Cys Ala 
        355                 360                 365             


Val Ala Leu Glu Ala Leu Lys Ile Tyr Arg Glu Arg Asn Ile Pro Ala 
    370                 375                 380                 


His Val Lys Gln Ile Ser Pro Arg Phe Gln Glu Gly Ile Lys Ala Phe 
385                 390                 395                 400 


Ala Gly Ser Ser Ile Ile Gly Glu Thr Arg Gly Val Gly Leu Leu Leu 
                405                 410                 415     


Ala Thr Glu Phe Ala Asn Asn Lys Ser Pro Asn Asp Pro Phe Pro Val 
            420                 425                 430         


Glu Trp Gly Val Ala Gln Ile Phe Gly Ala Glu Cys Lys Lys Arg Gly 
        435                 440                 445             


Met Leu Val Lys Val Val Gly Asp Glu Ile Ala Met Ser Pro Pro Leu 
    450                 455                 460                 


Ile Met Ser Gln Arg Glu Val Asp Gly Leu Val Ser Ile Tyr Gly Glu 
465                 470                 475                 480 


Ala Leu Lys Ala Thr Glu Glu Arg Val Ala Glu Leu Arg Ser Lys Lys 
                485                 490                 495     


Lys 
    


<210>  52
<211>  510
<212>  PRT
<213>  Oryza sativa subsp. japonica

<400>  52

Met Ile Cys Arg Ser Leu Leu Leu Leu Arg Ser Asn Ala Ala Ser Lys 
1               5                   10                  15      


Ala Ser Asn Ile Val Lys His Val Ala Ala Thr Gly Cys Leu Pro Lys 
            20                  25                  30          


Tyr Ser Ser Glu Ala Pro Ala Arg Tyr Phe Ser Ser Glu Pro Ser Leu 
        35                  40                  45              


Gln Val Asp Ser Thr Glu Glu Asn Gly Phe Lys Gly His Gly Met Leu 
    50                  55                  60                  


Ala Pro Phe Thr Ala Gly Trp Gln Ser Thr Asp Leu His Pro Leu Val 
65                  70                  75                  80  


Ile Asp Arg Ser Glu Gly Ser Tyr Val Tyr Asp Ile Asn Gly Lys Lys 
                85                  90                  95      


Tyr Ile Asp Ala Leu Ala Gly Leu Trp Ser Thr Ala Leu Gly Gly Asn 
            100                 105                 110         


Glu Pro Arg Leu Ile Lys Ala Ala Thr Asp Gln Leu Asn Lys Leu Pro 
        115                 120                 125             


Phe Tyr His Ser Phe Trp Asn Arg Thr Thr Lys Pro Ser Leu Asp Leu 
    130                 135                 140                 


Ala Asn Glu Ile Leu Ser Met Phe Thr Ala Arg Glu Met Gly Lys Ile 
145                 150                 155                 160 


Phe Phe Thr Asn Ser Gly Ser Glu Ala Asn Asp Ser Gln Val Lys Leu 
                165                 170                 175     


Val Trp Tyr Tyr Asn Asn Ala Leu Gly Arg Pro Asn Lys Lys Lys Phe 
            180                 185                 190         


Ile Ala Arg Ser Lys Ser Tyr His Gly Ser Thr Leu Val Ser Ala Ser 
        195                 200                 205             


Leu Ser Gly Leu Pro Ala Leu His Gln Lys Phe Asp Leu Pro Ala Pro 
    210                 215                 220                 


Phe Val Leu His Thr Asp Cys Pro His Tyr Trp Arg Phe His Leu Pro 
225                 230                 235                 240 


Asp Glu Thr Glu Glu Glu Phe Ala Thr Arg Leu Ala Thr Asn Leu Glu 
                245                 250                 255     


Asn Leu Ile Leu Lys Glu Gly Pro Glu Thr Ile Ala Ala Phe Ile Ala 
            260                 265                 270         


Glu Pro Val Met Gly Ala Gly Gly Val Ile Pro Pro Pro Lys Thr Tyr 
        275                 280                 285             


Phe Glu Lys Ile Gln Ala Val Leu Lys Lys Tyr Asp Ile Leu Leu Ile 
    290                 295                 300                 


Ala Asp Glu Val Ile Thr Ala Phe Gly Arg Leu Gly Thr Met Phe Gly 
305                 310                 315                 320 


Cys Asp Met Tyr Asp Ile Lys Pro Asp Leu Val Ser Ile Ala Lys Ala 
                325                 330                 335     


Leu Ser Ser Ala Tyr Met Pro Ile Gly Ala Ile Leu Val Ser Pro Glu 
            340                 345                 350         


Ile Thr Asp Val Ile Tyr Ser Gln Ser Asn Lys Leu Gly Ser Phe Ala 
        355                 360                 365             


His Gly Phe Thr Tyr Ser Gly His Pro Val Ser Cys Ala Val Ala Ile 
    370                 375                 380                 


Glu Ala Leu Lys Ile Tyr Lys Glu Arg Asn Ile Ile Glu His Val Gln 
385                 390                 395                 400 


Lys Ile Ala Pro Arg Phe Gln Glu Gly Ile Lys Ala Phe Ser Gly Ser 
                405                 410                 415     


Pro Ile Val Gly Glu Ile Arg Gly Leu Gly Leu Ile Leu Gly Thr Glu 
            420                 425                 430         


Phe Val Asp Asn Lys Ser Pro Asn Asp Pro Phe Pro Ala Glu Trp Gly 
        435                 440                 445             


Val Gly Ser Leu Phe Gly Ala Glu Cys Glu Lys Arg Gly Met Leu Ile 
    450                 455                 460                 


Arg Val Ala Gly Asp Asn Ile Met Leu Ser Pro Pro Leu Ile Met Thr 
465                 470                 475                 480 


Pro Asp Glu Val Glu Glu Ile Ile Cys Lys Tyr Gly Asp Ala Leu Lys 
                485                 490                 495     


Ala Thr Glu Glu Arg Ile Ala Glu Leu Lys Ala Lys Arg Gly 
            500                 505                 510 


<210>  53
<211>  497
<212>  PRT
<213>  Oryza sativa subsp. indica

<400>  53

Met Asn Leu Ile Lys His Ala Ala Phe Ala Ala Ser Phe Gln Gly Glu 
1               5                   10                  15      


Thr Asp Cys Thr Ser His Ala Ser Ala Arg Lys Phe Ser Thr Ser Gly 
            20                  25                  30          


Ser Ser Pro Leu Leu Asp Ser Thr Glu Gly Asn Gly Phe Lys Gly His 
        35                  40                  45              


Ser Met Leu Ala Pro Phe Thr Ala Gly Trp His Ser Thr Asp Leu Glu 
    50                  55                  60                  


Pro Leu Ile Ile Glu Arg Ser Glu Gly Ser Tyr Val Tyr Asp Ser Lys 
65                  70                  75                  80  


Gly Asn Lys Tyr Leu Asp Thr Leu Ala Gly Leu Trp Cys Thr Ala Leu 
                85                  90                  95      


Gly Gly Ser Glu Pro Arg Leu Val Lys Ala Ala Thr Asp Gln Leu Asn 
            100                 105                 110         


Lys Leu Pro Phe Tyr His Ser Phe Trp Asn Ser Thr Ala Lys Pro Pro 
        115                 120                 125             


Leu Asp Leu Ala Glu Glu Leu Ile Ser Met Phe Thr Ala Lys Glu Met 
    130                 135                 140                 


Gly Lys Val Phe Phe Thr Asn Ser Gly Ser Glu Ala Asn Asp Ser Gln 
145                 150                 155                 160 


Val Lys Leu Val Trp Tyr Tyr Asn Asn Ala Leu Gly Arg Pro Asn Lys 
                165                 170                 175     


Lys Lys Ile Ile Ala Gln Ser Gln Ala Tyr His Gly Ser Thr Leu Ile 
            180                 185                 190         


Ser Ala Ser Leu Ser Gly Leu Pro Ala Met His Leu Lys Phe Asp Leu 
        195                 200                 205             


Pro Ala Pro Phe Val Leu His Thr Asp Cys Pro His Tyr Trp Arg Phe 
    210                 215                 220                 


Gly Leu Pro Gly Glu Ala Glu Glu Glu Phe Ala Thr Arg Leu Ala Asp 
225                 230                 235                 240 


Asn Leu Glu Asn Leu Ile Leu Lys Glu Gly Pro Glu Thr Val Ala Ala 
                245                 250                 255     


Phe Ile Ala Glu Pro Val Ile Gly Ala Gly Gly Val Ile Pro Pro Pro 
            260                 265                 270         


Lys Thr Tyr Phe Glu Lys Ile Gln Ala Val Leu Gln Lys Tyr Asp Val 
        275                 280                 285             


Leu Phe Ile Ala Asp Glu Val Ile Thr Gly Phe Gly Arg Leu Gly Thr 
    290                 295                 300                 


Met Phe Gly Ser Asp Leu Tyr Asn Ile Lys Pro Asp Leu Val Ser Leu 
305                 310                 315                 320 


Ala Lys Ala Leu Ser Ser Ala Tyr Val Pro Ile Gly Ala Thr Leu Val 
                325                 330                 335     


Ser Pro Glu Ile Ser Asp Val Val His Ser Gln Ser Asn Lys Ile Gly 
            340                 345                 350         


Phe Phe Ala His Gly Phe Thr Tyr Ser Gly His Pro Val Ser Cys Ala 
        355                 360                 365             


Val Ala Leu Glu Ala Leu Lys Ile Tyr Arg Glu Arg Asn Ile Pro Ala 
    370                 375                 380                 


His Val Lys Gln Ile Ser Pro Arg Phe Gln Glu Gly Ile Lys Ala Phe 
385                 390                 395                 400 


Ala Gly Ser Ser Ile Ile Gly Glu Thr Arg Gly Val Gly Leu Leu Leu 
                405                 410                 415     


Ala Thr Glu Phe Ala Asn Asn Lys Ser Pro Asn Asp Pro Phe Pro Val 
            420                 425                 430         


Glu Trp Gly Val Ala Gln Ile Phe Gly Ala Glu Cys Lys Lys Arg Gly 
        435                 440                 445             


Met Leu Val Lys Val Val Gly Asp Glu Ile Ala Met Ser Pro Pro Leu 
    450                 455                 460                 


Ile Met Ser Gln Arg Glu Val Asp Gly Leu Val Ser Ile Tyr Gly Glu 
465                 470                 475                 480 


Ala Leu Lys Ala Thr Glu Glu Arg Val Ala Glu Leu Arg Ser Lys Lys 
                485                 490                 495     


Lys 
    


<210>  54
<211>  516
<212>  PRT
<213>  Oryza sativa subsp. indica

<400>  54

Met Val Ile Ala Arg Gly Leu Leu Arg Ser Asn Ala Ser Ser Ser Ser 
1               5                   10                  15      


Ser Gln Ala Ile Asn Leu Leu Lys Tyr Val Thr Ser Thr Gly Ser Leu 
            20                  25                  30          


Gln Gly His Thr Gln Asn Leu Cys Asp Ala Ser Thr Arg His Phe Ser 
        35                  40                  45              


Ser Val Pro Ser Pro Gln Ser Asn Ser Thr Glu Glu Asn Gly Phe Lys 
    50                  55                  60                  


Gly His Gly Met Leu Ala Pro Phe Thr Ala Gly Trp Gln Ser Thr Asp 
65                  70                  75                  80  


Val His Pro Leu Val Ile Glu Arg Ser Glu Gly Ser Tyr Val Tyr Asp 
                85                  90                  95      


Ile Asp Gly Lys Lys Tyr Leu Asp Ser Leu Ala Gly Leu Trp Cys Thr 
            100                 105                 110         


Ala Leu Gly Gly Ser Glu Pro Arg Leu Ala Lys Ala Ala Thr Glu Gln 
        115                 120                 125             


Leu His Lys Leu Pro Phe Tyr His Ser Phe Trp Asn Arg Thr Thr Lys 
    130                 135                 140                 


Pro Ser Leu Asp Leu Ala Lys Glu Leu Leu Ser Met Phe Thr Ala Arg 
145                 150                 155                 160 


Glu Met Gly Lys Val Phe Phe Thr Asn Ser Gly Ser Glu Ala Asn Asp 
                165                 170                 175     


Ser Gln Val Lys Leu Val Trp Tyr Tyr Asn Asn Ala Leu Gly Arg Pro 
            180                 185                 190         


Asp Lys Lys Lys Phe Ile Ala Arg Ser Lys Ser Tyr His Gly Ser Thr 
        195                 200                 205             


Leu Ile Ser Ala Ser Leu Ser Gly Leu Pro Ala Leu His Gln Lys Phe 
    210                 215                 220                 


Asp Leu Pro Ala Pro Phe Val Leu His Thr Asp Cys Pro His Tyr Trp 
225                 230                 235                 240 


Arg Phe His Leu Pro Gly Glu Thr Glu Glu Glu Phe Ala Thr Arg Leu 
                245                 250                 255     


Ala Asn Asn Leu Glu Glu Leu Ile Leu Lys Glu Gly Pro Glu Thr Ile 
            260                 265                 270         


Ala Ala Phe Ile Ala Glu Pro Val Met Gly Ala Gly Gly Val Ile Pro 
        275                 280                 285             


Pro Pro Lys Thr Tyr Phe Glu Lys Val Gln Ala Ile Val Lys Lys Tyr 
    290                 295                 300                 


Asp Ile Leu Phe Ile Ala Asp Glu Val Ile Thr Ala Phe Gly Arg Leu 
305                 310                 315                 320 


Gly Thr Met Phe Gly Ser Asp Met Tyr Asn Ile Lys Pro Asp Leu Val 
                325                 330                 335     


Ser Met Ala Lys Ala Leu Ser Ser Ala Tyr Val Pro Ile Gly Ala Ile 
            340                 345                 350         


Met Val Ser Pro Glu Ile Ser Asp Val Ile His Ser Gln Ser Asn Lys 
        355                 360                 365             


Leu Gly Ser Phe Ala His Gly Phe Thr Tyr Ser Gly His Pro Val Ala 
    370                 375                 380                 


Cys Ala Val Ala Ile Glu Ala Leu Lys Ile Tyr Gln Glu Arg Asn Ile 
385                 390                 395                 400 


Pro Asp His Val Lys Gln Ile Ser Pro Arg Phe Gln Glu Gly Val Lys 
                405                 410                 415     


Ala Phe Ala Gly Ser Pro Ile Val Gly Glu Ile Arg Gly Val Gly Leu 
            420                 425                 430         


Ile Leu Gly Thr Glu Phe Ala Asp Asn Lys Ser Pro Asn Asp Pro Phe 
        435                 440                 445             


Pro Ala Glu Trp Gly Val Gly Ala Ile Phe Gly Ala Glu Cys Gln Lys 
    450                 455                 460                 


Arg Gly Met Leu Val Arg Val Ala Gly Asp Asn Ile Met Met Ser Pro 
465                 470                 475                 480 


Pro Leu Ile Met Thr Pro Asp Glu Val Glu Glu Leu Val Ser Ile Tyr 
                485                 490                 495     


Gly Asp Ala Leu Lys Ala Thr Glu Glu Arg Val Ala Glu Leu Lys Ser 
            500                 505                 510         


Lys Lys Asn Asn 
        515     


<210>  55
<211>  510
<212>  PRT
<213>  Oryza sativa subsp. indica

<400>  55

Met Ile Cys Arg Ser Leu Leu Leu Leu Arg Ser Asn Ala Ala Ser Lys 
1               5                   10                  15      


Ala Ser Ser Ile Val Lys His Val Ala Ala Thr Gly Cys Leu Pro Glu 
            20                  25                  30          


Tyr Ser Ser Glu Ala Pro Ala Arg Tyr Phe Ser Ser Glu Ser Ser Leu 
        35                  40                  45              


Gln Val Asp Ser Thr Glu Glu Asn Gly Phe Lys Gly His Gly Met Leu 
    50                  55                  60                  


Ala Pro Phe Thr Ala Gly Trp Gln Ser Thr Asp Leu His Pro Leu Val 
65                  70                  75                  80  


Ile Asp Arg Ser Glu Gly Ser Tyr Val Tyr Asp Ile Asn Gly Lys Lys 
                85                  90                  95      


Tyr Ile Asp Ala Leu Ala Gly Leu Trp Ser Thr Ala Leu Gly Gly Asn 
            100                 105                 110         


Glu Pro Arg Leu Ile Lys Ala Ala Thr Asp Gln Leu Asn Lys Leu Pro 
        115                 120                 125             


Phe Tyr His Ser Phe Trp Asn Arg Thr Thr Lys Pro Ser Leu Asp Leu 
    130                 135                 140                 


Ala Asn Glu Ile Leu Ser Met Phe Thr Ala Arg Glu Met Gly Lys Ile 
145                 150                 155                 160 


Phe Phe Thr Asn Ser Gly Ser Glu Ala Asn Asp Ser Gln Val Lys Leu 
                165                 170                 175     


Val Trp Tyr Tyr Asn Asn Ala Leu Gly Arg Pro Asn Lys Lys Lys Phe 
            180                 185                 190         


Ile Ala Arg Ser Lys Ser Tyr His Gly Ser Thr Leu Val Ser Ala Ser 
        195                 200                 205             


Leu Ser Gly Leu Pro Ala Leu His Gln Lys Phe Asp Leu Pro Ala Pro 
    210                 215                 220                 


Phe Val Leu His Thr Asp Cys Pro His Tyr Trp Arg Phe His Leu Pro 
225                 230                 235                 240 


Asp Glu Thr Glu Glu Glu Phe Ala Thr Arg Leu Ala Thr Asn Leu Glu 
                245                 250                 255     


Asn Leu Ile Leu Lys Glu Gly Pro Glu Thr Ile Ala Ala Phe Ile Ala 
            260                 265                 270         


Glu Pro Val Met Gly Ala Gly Gly Val Ile Pro Pro Pro Lys Thr Tyr 
        275                 280                 285             


Phe Glu Lys Ile Gln Ala Val Leu Lys Lys Tyr Asp Ile Leu Leu Ile 
    290                 295                 300                 


Ala Asp Glu Val Ile Thr Ala Phe Gly Arg Leu Gly Thr Met Phe Gly 
305                 310                 315                 320 


Cys Asp Met Tyr Asp Ile Lys Pro Asp Leu Val Ser Ile Ala Lys Ala 
                325                 330                 335     


Leu Ser Ser Ala Tyr Met Pro Ile Gly Ala Ile Leu Val Ser Pro Glu 
            340                 345                 350         


Ile Thr Asp Val Ile Tyr Ser Gln Ser Asn Lys Leu Gly Ser Phe Ala 
        355                 360                 365             


His Gly Phe Thr Tyr Ser Gly His Pro Val Ser Cys Ala Val Ala Ile 
    370                 375                 380                 


Glu Ala Leu Lys Ile Tyr Lys Glu Arg Asn Ile Ile Glu His Val Gln 
385                 390                 395                 400 


Lys Ile Ala Pro Arg Phe Gln Glu Gly Ile Lys Ala Phe Ser Gly Ser 
                405                 410                 415     


Pro Ile Val Gly Glu Ile Arg Gly Leu Gly Leu Ile Leu Gly Thr Glu 
            420                 425                 430         


Phe Val Asp Asn Lys Ser Pro Asn Asp Pro Phe Pro Ala Glu Trp Gly 
        435                 440                 445             


Val Gly Ser Leu Phe Gly Ala Glu Cys Glu Lys Arg Gly Met Leu Ile 
    450                 455                 460                 


Arg Val Ala Gly Asp Asn Ile Met Leu Ser Pro Pro Leu Ile Met Thr 
465                 470                 475                 480 


Pro Asp Glu Val Glu Glu Ile Ile Ser Lys Tyr Gly Asp Ala Leu Lys 
                485                 490                 495     


Ala Thr Glu Glu Arg Ile Ala Glu Leu Lys Ala Lys Arg Gly 
            500                 505                 510 


<210>  56
<211>  426
<212>  PRT
<213>  Escherichia coli

<400>  56

Met Asn Ser Asn Lys Glu Leu Met Gln Arg Arg Ser Gln Ala Ile Pro 
1               5                   10                  15      


Arg Gly Val Gly Gln Ile His Pro Ile Phe Ala Asp Arg Ala Glu Asn 
            20                  25                  30          


Cys Arg Val Trp Asp Val Glu Gly Arg Glu Tyr Leu Asp Phe Ala Gly 
        35                  40                  45              


Gly Ile Ala Val Leu Asn Thr Gly His Leu His Pro Lys Val Val Ala 
    50                  55                  60                  


Ala Val Glu Ala Gln Leu Lys Lys Leu Ser His Thr Cys Phe Gln Val 
65                  70                  75                  80  


Leu Ala Tyr Glu Pro Tyr Leu Glu Leu Cys Glu Ile Met Asn Gln Lys 
                85                  90                  95      


Val Pro Gly Asp Phe Ala Lys Lys Thr Leu Leu Val Thr Thr Gly Ser 
            100                 105                 110         


Glu Ala Val Glu Asn Ala Val Lys Ile Ala Arg Ala Ala Thr Lys Arg 
        115                 120                 125             


Ser Gly Thr Ile Ala Phe Ser Gly Ala Tyr His Gly Arg Thr His Tyr 
    130                 135                 140                 


Thr Leu Ala Leu Thr Gly Lys Val Asn Pro Tyr Ser Ala Gly Met Gly 
145                 150                 155                 160 


Leu Met Pro Gly His Val Tyr Arg Ala Leu Tyr Pro Cys Pro Leu His 
                165                 170                 175     


Gly Ile Ser Glu Asp Asp Ala Ile Ala Ser Ile His Arg Ile Phe Lys 
            180                 185                 190         


Asn Asp Ala Ala Pro Glu Asp Ile Ala Ala Ile Val Ile Glu Pro Val 
        195                 200                 205             


Gln Gly Glu Gly Gly Phe Tyr Ala Ser Ser Pro Ala Phe Met Gln Arg 
    210                 215                 220                 


Leu Arg Ala Leu Cys Asp Glu His Gly Ile Met Leu Ile Ala Asp Glu 
225                 230                 235                 240 


Val Gln Ser Gly Ala Gly Arg Thr Gly Thr Leu Phe Ala Met Glu Gln 
                245                 250                 255     


Met Gly Val Ala Pro Asp Leu Thr Thr Phe Ala Lys Ser Ile Ala Gly 
            260                 265                 270         


Gly Phe Pro Leu Ala Gly Val Thr Gly Arg Ala Glu Val Met Asp Ala 
        275                 280                 285             


Val Ala Pro Gly Gly Leu Gly Gly Thr Tyr Ala Gly Asn Pro Ile Ala 
    290                 295                 300                 


Cys Val Ala Ala Leu Glu Val Leu Lys Val Phe Glu Gln Glu Asn Leu 
305                 310                 315                 320 


Leu Gln Lys Ala Asn Asp Leu Gly Gln Lys Leu Lys Asp Gly Leu Leu 
                325                 330                 335     


Ala Ile Ala Glu Lys His Pro Glu Ile Gly Asp Val Arg Gly Leu Gly 
            340                 345                 350         


Ala Met Ile Ala Ile Glu Leu Phe Glu Asp Gly Asp His Asn Lys Pro 
        355                 360                 365             


Asp Ala Lys Leu Thr Ala Glu Ile Val Ala Arg Ala Arg Asp Lys Gly 
    370                 375                 380                 


Leu Ile Leu Leu Ser Cys Gly Pro Tyr Tyr Asn Val Leu Arg Ile Leu 
385                 390                 395                 400 


Val Pro Leu Thr Ile Glu Asp Ala Gln Ile Arg Gln Gly Leu Glu Ile 
                405                 410                 415     


Ile Ser Gln Cys Phe Asp Glu Ala Lys Gln 
            420                 425     


<210>  57
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Ala Ser Met Leu Leu Ala Gln Arg Leu Ala Cys Ser Phe Gln His 
1               5                   10                  15      


Ser Tyr Arg Leu Leu Val Pro Gly Ser Arg His Ile Ser Gln Ala Ala 
            20                  25                  30          


Ala Lys Val Asp Val Glu Phe Asp Tyr Asp Gly Pro Leu Met Lys Thr 
        35                  40                  45              


Glu Val Pro Gly Pro Arg Ser Gln Glu Leu Met Lys Gln Leu Asn Ile 
    50                  55                  60                  


Ile Gln Asn Ala Glu Ala Val His Phe Phe Cys Asn Tyr Glu Glu Ser 
65                  70                  75                  80  


Arg Gly Asn Tyr Leu Val Asp Val Asp Gly Asn Arg Met Leu Asp Leu 
                85                  90                  95      


Tyr Ser Gln Ile Ser Ser Val Pro Ile Gly Tyr Ser His Pro Ala Leu 
            100                 105                 110         


Leu Lys Leu Ile Gln Gln Pro Gln Asn Ala Ser Met Phe Val Asn Arg 
        115                 120                 125             


Pro Ala Leu Gly Ile Leu Pro Pro Glu Asn Phe Val Glu Lys Leu Arg 
    130                 135                 140                 


Gln Ser Leu Leu Ser Val Ala Pro Lys Gly Met Ser Gln Leu Ile Thr 
145                 150                 155                 160 


Met Ala Cys Gly Ser Cys Ser Asn Glu Asn Ala Leu Lys Thr Ile Phe 
                165                 170                 175     


Met Trp Tyr Arg Ser Lys Glu Arg Gly Gln Arg Gly Phe Ser Gln Glu 
            180                 185                 190         


Glu Leu Glu Thr Cys Met Ile Asn Gln Ala Pro Gly Cys Pro Asp Tyr 
        195                 200                 205             


Ser Ile Leu Ser Phe Met Gly Ala Phe His Gly Arg Thr Met Gly Cys 
    210                 215                 220                 


Leu Ala Thr Thr His Ser Lys Ala Ile His Lys Ile Asp Ile Pro Ser 
225                 230                 235                 240 


Phe Asp Trp Pro Ile Ala Pro Phe Pro Arg Leu Lys Tyr Pro Leu Glu 
                245                 250                 255     


Glu Phe Val Lys Glu Asn Gln Gln Glu Glu Ala Arg Cys Leu Glu Glu 
            260                 265                 270         


Val Glu Asp Leu Ile Val Lys Tyr Arg Lys Lys Lys Lys Thr Val Ala 
        275                 280                 285             


Gly Ile Ile Val Glu Pro Ile Gln Ser Glu Gly Gly Asp Asn His Ala 
    290                 295                 300                 


Ser Asp Asp Phe Phe Arg Lys Leu Arg Asp Ile Ala Arg Lys His Gly 
305                 310                 315                 320 


Cys Ala Phe Leu Val Asp Glu Val Gln Thr Gly Gly Gly Cys Thr Gly 
                325                 330                 335     


Lys Phe Trp Ala His Glu His Trp Gly Leu Asp Asp Pro Ala Asp Val 
            340                 345                 350         


Met Thr Phe Ser Lys Lys Met Met Thr Gly Gly Phe Phe His Lys Glu 
        355                 360                 365             


Glu Phe Arg Pro Asn Ala Pro Tyr Arg Ile Phe Asn Thr Trp Leu Gly 
    370                 375                 380                 


Asp Pro Ser Lys Asn Leu Leu Leu Ala Glu Val Ile Asn Ile Ile Lys 
385                 390                 395                 400 


Arg Glu Asp Leu Leu Asn Asn Ala Ala His Ala Gly Lys Ala Leu Leu 
                405                 410                 415     


Thr Gly Leu Leu Asp Leu Gln Ala Arg Tyr Pro Gln Phe Ile Ser Arg 
            420                 425                 430         


Val Arg Gly Arg Gly Thr Phe Cys Ser Phe Asp Thr Pro Asp Asp Ser 
        435                 440                 445             


Ile Arg Asn Lys Leu Ile Leu Ile Ala Arg Asn Lys Gly Val Val Leu 
    450                 455                 460                 


Gly Gly Cys Gly Asp Lys Ser Ile Arg Phe Arg Pro Thr Leu Val Phe 
465                 470                 475                 480 


Arg Asp His His Ala His Leu Phe Leu Asn Ile Phe Ser Asp Ile Leu 
                485                 490                 495     


Ala Asp Phe Lys 
            500 


<210>  58
<211>  500
<212>  PRT
<213>  Rattus norvegicus

<400>  58

Met Ala Phe Leu Leu Thr Thr Arg Arg Leu Val Cys Ser Ser Gln Lys 
1               5                   10                  15      


Asn Leu His Leu Phe Thr Pro Gly Ser Arg Tyr Ile Ser Gln Ala Ala 
            20                  25                  30          


Ala Lys Val Asp Phe Glu Phe Asp Tyr Asp Gly Pro Leu Met Lys Thr 
        35                  40                  45              


Glu Val Pro Gly Pro Arg Ser Gln Glu Leu Met Lys Gln Leu Asn Thr 
    50                  55                  60                  


Ile Gln Asn Ala Glu Ala Val His Phe Phe Cys Asn Tyr Glu Glu Ser 
65                  70                  75                  80  


Arg Gly Asn Tyr Leu Val Asp Val Asp Gly Asn Arg Met Leu Asp Leu 
                85                  90                  95      


Tyr Ser Gln Ile Ser Ser Val Pro Ile Gly Tyr Asn His Pro Ala Leu 
            100                 105                 110         


Ala Lys Leu Val Gln Gln Pro Gln Asn Ala Ser Thr Phe Ile Asn Arg 
        115                 120                 125             


Pro Ala Leu Gly Ile Leu Pro Pro Glu Asn Phe Val Asp Lys Leu Arg 
    130                 135                 140                 


Glu Ser Leu Met Ser Val Ala Pro Lys Gly Met Cys Gln Leu Ile Thr 
145                 150                 155                 160 


Met Ala Cys Gly Ser Cys Ser Asn Glu Asn Ala Phe Lys Thr Ile Phe 
                165                 170                 175     


Met Trp Tyr Arg Ser Lys Glu Arg Gly Gln Arg Gly Phe Ser Lys Glu 
            180                 185                 190         


Glu Leu Glu Thr Cys Met Val Asn Gln Ser Pro Gly Cys Pro Asp Tyr 
        195                 200                 205             


Ser Ile Leu Ser Phe Met Gly Ala Phe His Gly Arg Thr Met Gly Cys 
    210                 215                 220                 


Leu Ala Thr Thr His Ser Lys Ala Ile His Lys Ile Asp Ile Pro Ser 
225                 230                 235                 240 


Phe Asp Trp Pro Ile Ala Pro Phe Pro Arg Leu Lys Tyr Pro Leu Glu 
                245                 250                 255     


Glu Phe Val Thr Asp Asn Gln Gln Glu Glu Ala Arg Cys Leu Glu Glu 
            260                 265                 270         


Val Glu Asp Leu Ile Val Lys Tyr Arg Lys Lys Lys Arg Thr Val Ala 
        275                 280                 285             


Gly Ile Ile Val Glu Pro Ile Gln Ser Glu Gly Gly Asp Asn His Ala 
    290                 295                 300                 


Ser Asp Asp Phe Phe Arg Lys Leu Arg Asp Ile Ala Arg Lys His Gly 
305                 310                 315                 320 


Cys Ala Phe Leu Val Asp Glu Val Gln Thr Gly Gly Gly Cys Thr Gly 
                325                 330                 335     


Lys Phe Trp Ala His Glu His Trp Gly Leu Asp Asp Pro Ala Asp Val 
            340                 345                 350         


Met Ser Phe Ser Lys Lys Met Met Thr Gly Gly Phe Phe His Lys Glu 
        355                 360                 365             


Glu Phe Arg Pro Ser Ala Pro Tyr Arg Ile Phe Asn Thr Trp Leu Gly 
    370                 375                 380                 


Asp Pro Ser Lys Asn Leu Leu Leu Ala Glu Val Ile Asn Ile Ile Lys 
385                 390                 395                 400 


Arg Glu Asp Leu Leu Asn Asn Val Ala His Ala Gly Lys Thr Leu Leu 
                405                 410                 415     


Thr Gly Leu Leu Asp Leu Gln Ala Gln Tyr Pro Gln Phe Val Ser Arg 
            420                 425                 430         


Val Arg Gly Arg Gly Thr Phe Cys Ser Phe Asp Thr Pro Asp Glu Ala 
        435                 440                 445             


Ile Arg Asn Lys Leu Ile Leu Ile Ala Arg Asn Lys Gly Val Val Leu 
    450                 455                 460                 


Gly Gly Cys Gly Asp Lys Ser Ile Arg Phe Arg Pro Thr Leu Val Phe 
465                 470                 475                 480 


Arg Asp His His Ala His Leu Phe Leu Asn Ile Phe Ser Gly Ile Leu 
                485                 490                 495     


Ala Asp Phe Lys 
            500 


<210>  59
<211>  500
<212>  PRT
<213>  Sus scrofa

<400>  59

Met Ala Ser Val Leu Leu Thr Arg Arg Leu Ala Cys Ser Phe Arg His 
1               5                   10                  15      


Asn His Arg Leu Leu Val Pro Gly Trp Arg His Ile Ser Gln Ala Ala 
            20                  25                  30          


Ala Lys Val Asp Val Glu Phe Asp Tyr Asp Gly Pro Leu Met Lys Thr 
        35                  40                  45              


Glu Val Pro Gly Pro Arg Ser Arg Glu Leu Met Lys Gln Leu Asn Ile 
    50                  55                  60                  


Ile Gln Asn Ala Glu Ala Val His Phe Phe Cys Asn Tyr Glu Glu Ser 
65                  70                  75                  80  


Arg Gly Asn Tyr Leu Val Asp Val Asp Gly Asn Arg Met Leu Asp Leu 
                85                  90                  95      


Tyr Ser Gln Ile Ser Ser Ile Pro Ile Gly Tyr Ser His Pro Ala Leu 
            100                 105                 110         


Val Lys Leu Val Gln Gln Pro Gln Asn Val Ser Thr Phe Ile Asn Arg 
        115                 120                 125             


Pro Ala Leu Gly Ile Leu Pro Pro Glu Asn Phe Val Glu Lys Leu Arg 
    130                 135                 140                 


Glu Ser Leu Leu Ser Val Ala Pro Lys Gly Met Ser Gln Leu Ile Thr 
145                 150                 155                 160 


Met Ala Cys Gly Ser Cys Ser Asn Glu Asn Ala Phe Lys Thr Ile Phe 
                165                 170                 175     


Met Trp Tyr Arg Ser Lys Glu Arg Gly Gln Ser Ala Phe Ser Lys Glu 
            180                 185                 190         


Glu Leu Glu Thr Cys Met Ile Asn Gln Ala Pro Gly Cys Pro Asp Tyr 
        195                 200                 205             


Ser Ile Leu Ser Phe Met Gly Ala Phe His Gly Arg Thr Met Gly Cys 
    210                 215                 220                 


Leu Ala Thr Thr His Ser Lys Ala Ile His Lys Ile Asp Ile Pro Ser 
225                 230                 235                 240 


Phe Asp Trp Pro Ile Ala Pro Phe Pro Arg Leu Lys Tyr Pro Leu Glu 
                245                 250                 255     


Glu Phe Val Lys Glu Asn Gln Gln Glu Glu Ala Arg Cys Leu Glu Glu 
            260                 265                 270         


Val Glu Asp Leu Ile Val Lys Tyr Arg Lys Lys Lys Lys Thr Val Ala 
        275                 280                 285             


Gly Ile Ile Val Glu Pro Ile Gln Ser Glu Gly Gly Asp Asn His Ala 
    290                 295                 300                 


Ser Asp Asp Phe Phe Arg Lys Leu Arg Asp Ile Ser Arg Lys His Gly 
305                 310                 315                 320 


Cys Ala Phe Leu Val Asp Glu Val Gln Thr Gly Gly Gly Ser Thr Gly 
                325                 330                 335     


Lys Phe Trp Ala His Glu His Trp Gly Leu Asp Asp Pro Ala Asp Val 
            340                 345                 350         


Met Thr Phe Ser Lys Lys Met Met Thr Gly Gly Phe Phe His Lys Glu 
        355                 360                 365             


Glu Phe Arg Pro Asn Ala Pro Tyr Arg Ile Phe Asn Thr Trp Leu Gly 
    370                 375                 380                 


Asp Pro Ser Lys Asn Leu Leu Leu Ala Glu Val Ile Asn Ile Ile Lys 
385                 390                 395                 400 


Arg Glu Asp Leu Leu Ser Asn Ala Ala His Ala Gly Lys Val Leu Leu 
                405                 410                 415     


Thr Gly Leu Leu Asp Leu Gln Ala Arg Tyr Pro Gln Phe Ile Ser Arg 
            420                 425                 430         


Val Arg Gly Arg Gly Thr Phe Cys Ser Phe Asp Thr Pro Asp Glu Ser 
        435                 440                 445             


Ile Arg Asn Lys Leu Ile Ser Ile Ala Arg Asn Lys Gly Val Met Leu 
    450                 455                 460                 


Gly Gly Cys Gly Asp Lys Ser Ile Arg Phe Arg Pro Thr Leu Val Phe 
465                 470                 475                 480 


Arg Asp His His Ala His Leu Phe Leu Asn Ile Phe Ser Asp Ile Leu 
                485                 490                 495     


Ala Asp Phe Lys 
            500 


<210>  60
<211>  421
<212>  PRT
<213>  Escherichia coli

<400>  60

Met Ser Asn Asn Glu Phe His Gln Arg Arg Leu Ser Ala Thr Pro Arg 
1               5                   10                  15      


Gly Val Gly Val Met Cys Asn Phe Phe Ala Gln Ser Ala Glu Asn Ala 
            20                  25                  30          


Thr Leu Lys Asp Val Glu Gly Asn Glu Tyr Ile Asp Phe Ala Ala Gly 
        35                  40                  45              


Ile Ala Val Leu Asn Thr Gly His Arg His Pro Asp Leu Val Ala Ala 
    50                  55                  60                  


Val Glu Gln Gln Leu Gln Gln Phe Thr His Thr Ala Tyr Gln Ile Val 
65                  70                  75                  80  


Pro Tyr Glu Ser Tyr Val Thr Leu Ala Glu Lys Ile Asn Ala Leu Ala 
                85                  90                  95      


Pro Val Ser Gly Gln Ala Lys Thr Ala Phe Phe Thr Thr Gly Ala Glu 
            100                 105                 110         


Ala Val Glu Asn Ala Val Lys Ile Ala Arg Ala His Thr Gly Arg Pro 
        115                 120                 125             


Gly Val Ile Ala Phe Ser Gly Gly Phe His Gly Arg Thr Tyr Met Thr 
    130                 135                 140                 


Met Ala Leu Thr Gly Lys Val Ala Pro Tyr Lys Ile Gly Phe Gly Pro 
145                 150                 155                 160 


Phe Pro Gly Ser Val Tyr His Val Pro Tyr Pro Ser Asp Leu His Gly 
                165                 170                 175     


Ile Ser Thr Gln Asp Ser Leu Asp Ala Ile Glu Arg Leu Phe Lys Ser 
            180                 185                 190         


Asp Ile Glu Ala Lys Gln Val Ala Ala Ile Ile Phe Glu Pro Val Gln 
        195                 200                 205             


Gly Glu Gly Gly Phe Asn Val Ala Pro Lys Glu Leu Val Ala Ala Ile 
    210                 215                 220                 


Arg Arg Leu Cys Asp Glu His Gly Ile Val Met Ile Ala Asp Glu Val 
225                 230                 235                 240 


Gln Ser Gly Phe Ala Arg Thr Gly Lys Leu Phe Ala Met Asp His Tyr 
                245                 250                 255     


Ala Asp Lys Pro Asp Leu Met Thr Met Ala Lys Ser Leu Ala Gly Gly 
            260                 265                 270         


Met Pro Leu Ser Gly Val Val Gly Asn Ala Asn Ile Met Asp Ala Pro 
        275                 280                 285             


Ala Pro Gly Gly Leu Gly Gly Thr Tyr Ala Gly Asn Pro Leu Ala Val 
    290                 295                 300                 


Ala Ala Ala His Ala Val Leu Asn Ile Ile Asp Lys Glu Ser Leu Cys 
305                 310                 315                 320 


Glu Arg Ala Asn Gln Leu Gly Gln Arg Leu Lys Asn Thr Leu Ile Asp 
                325                 330                 335     


Ala Lys Glu Ser Val Pro Ala Ile Ala Ala Val Arg Gly Leu Gly Ser 
            340                 345                 350         


Met Ile Ala Val Glu Phe Asn Asp Pro Gln Thr Gly Glu Pro Ser Ala 
        355                 360                 365             


Ala Ile Ala Gln Lys Ile Gln Gln Arg Ala Leu Ala Gln Gly Leu Leu 
    370                 375                 380                 


Leu Leu Thr Cys Gly Ala Tyr Gly Asn Val Ile Arg Phe Leu Tyr Pro 
385                 390                 395                 400 


Leu Thr Ile Pro Asp Ala Gln Phe Asp Ala Ala Met Lys Ile Leu Gln 
                405                 410                 415     


Asp Ala Leu Ser Asp 
            420     


<210>  61
<211>  500
<212>  PRT
<213>  Mus musculus

<400>  61

Met Ala Phe Leu Leu Ile Thr Arg Arg Leu Ala Cys Ser Ser Gln Lys 
1               5                   10                  15      


Asn Leu His Leu Phe Ile Pro Gly Ser Arg Tyr Ile Ser Gln Ala Ala 
            20                  25                  30          


Ala Lys Val Asp Ile Glu Phe Asp Tyr Asp Gly Pro Leu Met Lys Thr 
        35                  40                  45              


Glu Val Pro Gly Pro Arg Ser Lys Glu Leu Met Lys Gln Leu Asn Thr 
    50                  55                  60                  


Ile Gln Asn Ala Glu Ala Val His Phe Phe Cys Asn Tyr Glu Glu Ser 
65                  70                  75                  80  


Arg Gly Asn Tyr Leu Val Asp Val Asp Gly Asn Arg Met Leu Asp Leu 
                85                  90                  95      


Tyr Ser Gln Ile Ser Ser Val Pro Ile Gly Tyr Asn His Pro Ala Leu 
            100                 105                 110         


Ala Lys Leu Val Gln Gln Pro Gln Asn Ala Ser Thr Phe Ile Asn Arg 
        115                 120                 125             


Pro Ala Leu Gly Ile Leu Pro Pro Glu Asn Phe Val Asp Lys Leu Gln 
    130                 135                 140                 


Glu Ser Leu Met Ser Val Ala Pro Arg Gly Met Ser Gln Leu Ile Thr 
145                 150                 155                 160 


Met Ala Cys Gly Ser Cys Ser Asn Glu Asn Ala Phe Lys Thr Ile Phe 
                165                 170                 175     


Met Trp Tyr Arg Ser Lys Glu Arg Gly Gln Arg Gly Phe Ser Lys Glu 
            180                 185                 190         


Glu Leu Glu Thr Cys Met Val Asn Gln Ser Pro Gly Cys Pro Asp Tyr 
        195                 200                 205             


Ser Ile Leu Ser Phe Met Gly Ala Phe His Gly Arg Thr Met Gly Cys 
    210                 215                 220                 


Leu Ala Thr Thr His Ser Lys Ala Ile His Lys Ile Asp Ile Pro Ser 
225                 230                 235                 240 


Phe Asp Trp Pro Ile Ala Pro Phe Pro Arg Leu Lys Tyr Pro Leu Glu 
                245                 250                 255     


Glu Phe Thr Thr Asp Asn Gln Gln Glu Glu Ala Arg Cys Leu Glu Glu 
            260                 265                 270         


Val Glu Asp Leu Ile Val Lys Tyr Arg Lys Lys Lys Arg Thr Val Ala 
        275                 280                 285             


Gly Ile Ile Val Glu Pro Ile Gln Ser Glu Gly Gly Asp Asn His Ala 
    290                 295                 300                 


Ser Asp Asp Phe Phe Arg Lys Leu Arg Asp Ile Ala Arg Lys His Gly 
305                 310                 315                 320 


Cys Ala Phe Leu Val Asp Glu Val Gln Thr Gly Gly Gly Cys Thr Gly 
                325                 330                 335     


Lys Phe Trp Ala His Glu His Trp Gly Leu Asp Asp Pro Ala Asp Val 
            340                 345                 350         


Met Thr Phe Ser Lys Lys Met Met Thr Gly Gly Phe Phe His Lys Glu 
        355                 360                 365             


Glu Phe Arg Pro Ser Ala Pro Tyr Arg Ile Phe Asn Thr Trp Leu Gly 
    370                 375                 380                 


Asp Pro Ser Lys Asn Leu Leu Leu Ala Glu Val Ile Asn Ile Ile Lys 
385                 390                 395                 400 


Arg Glu Asp Leu Leu Asn Asn Val Ala Arg Val Gly Lys Thr Leu Leu 
                405                 410                 415     


Thr Gly Leu Leu Asp Leu Gln Ala Gln Tyr Pro Gln Phe Ile Ser Arg 
            420                 425                 430         


Val Arg Gly Arg Gly Thr Phe Cys Ser Phe Asp Thr Pro Asp Glu Ala 
        435                 440                 445             


Ile Arg Asn Lys Leu Ile Leu Ile Ala Arg Asn Lys Gly Val Val Leu 
    450                 455                 460                 


Gly Gly Cys Gly Asp Lys Ser Ile Arg Phe Arg Pro Thr Leu Val Phe 
465                 470                 475                 480 


Arg Asp His His Ala His Leu Phe Leu Ser Ile Phe Ser Gly Ile Leu 
                485                 490                 495     


Ala Asp Phe Lys 
            500 


<210>  62
<211>  500
<212>  PRT
<213>  Bos taurus

<400>  62

Met Ala Ser Met Leu Val Ala Gln Arg Leu Ala Cys Ser Phe Gln His 
1               5                   10                  15      


Ser Tyr Arg Leu Leu Val Pro Gly Ser Arg His Ile Ser Gln Ala Ala 
            20                  25                  30          


Ala Lys Val Asp Val Glu Phe Asp Tyr Asp Gly Arg Leu Met Lys Thr 
        35                  40                  45              


Glu Val Pro Gly Leu Arg Cys Gln Glu Leu Met Lys Gln Leu Asn Ile 
    50                  55                  60                  


Ile Gln Asn Ala Glu Ala Val His Phe Phe Cys Asn Tyr Glu Glu Ser 
65                  70                  75                  80  


Arg Gly Asn Tyr Leu Val Asp Val Asp Gly Asn Arg Met Leu Asp Leu 
                85                  90                  95      


Tyr Ser Gln Ile Ser Ser Val Pro Ile Gly Tyr Ser His Pro Gly Leu 
            100                 105                 110         


Leu Lys Leu Ile Gln Gln Pro Gln Asn Ala Ser Met Phe Val Asn Arg 
        115                 120                 125             


Pro Ala Leu Gly Ile Leu Leu Pro Glu Asn Phe Val Glu Lys Leu Arg 
    130                 135                 140                 


Gln Ser Leu Leu Ser Val Ala Pro Lys Gly Met Ser Gln Leu Ile Thr 
145                 150                 155                 160 


Met Ala Cys Gly Ser Cys Ser Asn Glu Asn Gly Leu Lys Thr Ile Phe 
                165                 170                 175     


Met Trp Tyr Arg Ser Lys Glu Arg Gly Gln Arg Gly Phe Pro Gln Glu 
            180                 185                 190         


Glu Leu Glu Thr Cys Met Ile Asn Gln Ala Pro Trp Cys Pro Asp Tyr 
        195                 200                 205             


Ser Ile Leu Ser Phe Met Gly Ala Phe His Gly Arg Thr Met Gly Cys 
    210                 215                 220                 


Leu Ala Thr Thr His Ser Lys Ala Ile His Lys Ile Asp Ile Pro Ser 
225                 230                 235                 240 


Phe Asp Trp Pro Ile Ala Pro Phe Pro Arg Leu Lys Tyr Pro Leu Glu 
                245                 250                 255     


Glu Phe Val Lys Glu Asn Gln Gln Glu Glu Ala Arg Cys Leu Glu Glu 
            260                 265                 270         


Val Glu Asp Leu Ile Val Lys Tyr Arg Lys Lys Lys Lys Thr Val Ala 
        275                 280                 285             


Gly Ile Ile Val Glu Pro Ile Gln Ser Glu Gly Gly Asp Asn His Ala 
    290                 295                 300                 


Ser Asp Asp Phe Phe Arg Lys Leu Arg Asp Ile Pro Arg Lys Gln Cys 
305                 310                 315                 320 


Cys Ala Phe Leu Val Asp Val Val Gln Thr Gly Gly Gly Cys Thr Gly 
                325                 330                 335     


Lys Phe Trp Ala His Glu His Trp Ala Arg Asp Asp Pro Glu Asp Val 
            340                 345                 350         


Met Thr Ser Ser Lys Lys Met Met Thr Gly Gly Phe Phe His Lys Glu 
        355                 360                 365             


Glu Phe Arg Pro Asn Ala Pro Tyr Arg Ile Phe Asn Thr Trp Leu Gly 
    370                 375                 380                 


Asp Pro Ser Lys Asn Leu Leu Leu Ala Glu Val Ile Asn Ile Ile Lys 
385                 390                 395                 400 


Arg Glu Asp Leu Leu Asn Asn Ala Ala His Ala Gly Lys Ala Leu Leu 
                405                 410                 415     


Thr Gly Leu Leu Asp Leu Gln Ala Arg Tyr Pro Gln Phe Ile Ser Arg 
            420                 425                 430         


Val Arg Gly Arg Gly Thr Phe Cys Ser Phe Asp Thr Pro Asp Asp Ser 
        435                 440                 445             


Ile Arg Asn Lys Leu Ile Leu Ile Ala Arg Asn Lys Gly Val Val Leu 
    450                 455                 460                 


Gly Gly Cys Gly Asp Lys Ser Ile Arg Phe Arg Pro Thr Leu Val Phe 
465                 470                 475                 480 


Arg Asp His His Ala His Leu Phe Leu Asn Ile Phe Ser Asp Ile Leu 
                485                 490                 495     


Ala Asp Phe Lys 
            500 


<210>  63
<211>  471
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  63

Met Ser Ile Cys Glu Gln Tyr Tyr Pro Glu Glu Pro Thr Lys Pro Thr 
1               5                   10                  15      


Val Lys Thr Glu Ser Ile Pro Gly Pro Glu Ser Gln Lys Gln Leu Lys 
            20                  25                  30          


Glu Leu Gly Glu Val Phe Asp Thr Arg Pro Ala Tyr Phe Leu Ala Asp 
        35                  40                  45              


Tyr Glu Lys Ser Leu Gly Asn Tyr Ile Thr Asp Val Asp Gly Asn Thr 
    50                  55                  60                  


Tyr Leu Asp Leu Tyr Ala Gln Ile Ser Ser Ile Ala Leu Gly Tyr Asn 
65                  70                  75                  80  


Asn Pro Ala Leu Ile Lys Ala Ala Gln Ser Pro Glu Met Ile Arg Ala 
                85                  90                  95      


Leu Val Asp Arg Pro Ala Leu Gly Asn Phe Pro Ser Lys Asp Leu Asp 
            100                 105                 110         


Lys Ile Leu Lys Gln Ile Leu Lys Ser Ala Pro Lys Gly Gln Asp His 
        115                 120                 125             


Val Trp Ser Gly Leu Ser Gly Ala Asp Ala Asn Glu Leu Ala Phe Lys 
    130                 135                 140                 


Ala Ala Phe Ile Tyr Tyr Arg Ala Lys Gln Arg Gly Tyr Asp Ala Asp 
145                 150                 155                 160 


Phe Ser Glu Lys Glu Asn Leu Ser Val Met Asp Asn Asp Ala Pro Gly 
                165                 170                 175     


Ala Pro His Leu Ala Val Leu Ser Phe Lys Arg Ala Phe His Gly Arg 
            180                 185                 190         


Leu Phe Ala Ser Gly Ser Thr Thr Cys Ser Lys Pro Ile His Lys Leu 
        195                 200                 205             


Asp Phe Pro Ala Phe His Trp Pro His Ala Glu Tyr Pro Ser Tyr Gln 
    210                 215                 220                 


Tyr Pro Leu Asp Glu Asn Ser Asp Ala Asn Arg Lys Glu Asp Asp His 
225                 230                 235                 240 


Cys Leu Ala Ile Val Glu Glu Leu Ile Lys Thr Trp Ser Ile Pro Val 
                245                 250                 255     


Ala Ala Leu Ile Ile Glu Pro Ile Gln Ser Glu Gly Gly Asp Asn His 
            260                 265                 270         


Ala Ser Lys Tyr Phe Leu Gln Lys Leu Arg Asp Ile Thr Leu Lys Tyr 
        275                 280                 285             


Asn Val Val Tyr Ile Ile Asp Glu Val Gln Thr Gly Val Gly Ala Thr 
    290                 295                 300                 


Gly Lys Leu Trp Cys His Glu Tyr Ala Asp Ile Gln Pro Pro Val Asp 
305                 310                 315                 320 


Leu Val Thr Phe Ser Lys Lys Phe Gln Ser Ala Gly Tyr Phe Phe His 
                325                 330                 335     


Asp Pro Lys Phe Ile Pro Asn Lys Pro Tyr Arg Gln Phe Asn Thr Trp 
            340                 345                 350         


Cys Gly Glu Pro Ala Arg Met Ile Ile Ala Gly Ala Ile Gly Gln Glu 
        355                 360                 365             


Ile Ser Asp Lys Lys Leu Thr Glu Gln Cys Ser Arg Val Gly Asp Tyr 
    370                 375                 380                 


Leu Phe Lys Lys Leu Glu Gly Leu Gln Lys Lys Tyr Pro Glu Asn Phe 
385                 390                 395                 400 


Gln Asn Leu Arg Gly Lys Gly Arg Gly Thr Phe Ile Ala Trp Asp Leu 
                405                 410                 415     


Pro Thr Gly Glu Lys Arg Asp Leu Leu Leu Lys Lys Leu Lys Leu Asn 
            420                 425                 430         


Gly Cys Asn Val Gly Gly Cys Ala Val His Ala Val Arg Leu Arg Pro 
        435                 440                 445             


Ser Leu Thr Phe Glu Glu Lys His Ala Asp Ile Phe Ile Glu Ala Leu 
    450                 455                 460                 


Ala Lys Ser Val Asn Glu Leu 
465                 470     


<210>  64
<211>  474
<212>  PRT
<213>  Schizosaccharomyces pombe

<400>  64

Met Ser Ser Thr Ala Thr Val Thr Glu Ser Thr His Phe Phe Pro Asn 
1               5                   10                  15      


Glu Pro Gln Gly Pro Ser Ile Lys Thr Glu Thr Ile Pro Gly Pro Lys 
            20                  25                  30          


Gly Lys Ala Ala Ala Glu Glu Met Ser Lys Tyr His Asp Ile Ser Ala 
        35                  40                  45              


Val Lys Phe Pro Val Asp Tyr Glu Lys Ser Ile Gly Asn Tyr Leu Val 
    50                  55                  60                  


Asp Leu Asp Gly Asn Val Leu Leu Asp Val Tyr Ser Gln Ile Ala Thr 
65                  70                  75                  80  


Ile Pro Ile Gly Tyr Asn Asn Pro Thr Leu Leu Lys Ala Ala Lys Ser 
                85                  90                  95      


Asp Glu Val Ala Thr Ile Leu Met Asn Arg Pro Ala Leu Gly Asn Tyr 
            100                 105                 110         


Pro Pro Lys Glu Trp Ala Arg Val Ala Tyr Glu Gly Ala Ile Lys Tyr 
        115                 120                 125             


Ala Pro Lys Gly Gln Lys Tyr Val Tyr Phe Gln Met Ser Gly Ser Asp 
    130                 135                 140                 


Ala Asn Glu Ile Ala Tyr Lys Leu Ala Met Leu His His Phe Asn Asn 
145                 150                 155                 160 


Lys Pro Arg Pro Thr Gly Asp Tyr Thr Ala Glu Glu Asn Glu Ser Cys 
                165                 170                 175     


Leu Asn Asn Ala Ala Pro Gly Ser Pro Glu Val Ala Val Leu Ser Phe 
            180                 185                 190         


Arg His Ser Phe His Gly Arg Leu Phe Gly Ser Leu Ser Thr Thr Arg 
        195                 200                 205             


Ser Lys Pro Val His Lys Leu Gly Met Pro Ala Phe Pro Trp Pro Gln 
    210                 215                 220                 


Ala Asp Phe Pro Ala Leu Lys Tyr Pro Leu Glu Glu His Val Glu Glu 
225                 230                 235                 240 


Asn Ala Lys Glu Glu Gln Arg Cys Ile Asp Gln Val Glu Gln Ile Leu 
                245                 250                 255     


Thr Asn His His Cys Pro Val Val Ala Cys Ile Ile Glu Pro Ile Gln 
            260                 265                 270         


Ser Glu Gly Gly Asp Asn His Ala Ser Pro Asp Phe Phe His Lys Leu 
        275                 280                 285             


Gln Ala Thr Leu Lys Lys His Asp Val Lys Phe Ile Val Asp Glu Val 
    290                 295                 300                 


Gln Thr Gly Val Gly Ser Thr Gly Thr Leu Trp Ala His Glu Gln Trp 
305                 310                 315                 320 


Asn Leu Pro Tyr Pro Pro Asp Met Val Thr Phe Ser Lys Lys Phe Gln 
                325                 330                 335     


Ala Ala Gly Ile Phe Tyr His Asp Leu Ala Leu Arg Pro His Ala Tyr 
            340                 345                 350         


Gln His Phe Asn Thr Trp Met Gly Asp Pro Phe Arg Ala Val Gln Ser 
        355                 360                 365             


Arg Tyr Ile Leu Gln Glu Ile Gln Asp Lys Asp Leu Leu Asn Asn Val 
    370                 375                 380                 


Lys Ser Val Gly Asp Phe Leu Tyr Ala Gly Leu Glu Glu Leu Ala Arg 
385                 390                 395                 400 


Lys His Pro Gly Lys Ile Asn Asn Leu Arg Gly Lys Gly Lys Gly Thr 
                405                 410                 415     


Phe Ile Ala Trp Asp Cys Glu Ser Pro Ala Ala Arg Asp Lys Phe Cys 
            420                 425                 430         


Ala Asp Met Arg Ile Asn Gly Val Asn Ile Gly Gly Cys Gly Val Ala 
        435                 440                 445             


Ala Ile Arg Leu Arg Pro Met Leu Val Phe Gln Lys His His Ala Gln 
    450                 455                 460                 


Ile Leu Leu Lys Lys Ile Asp Glu Leu Ile 
465                 470                 


<210>  65
<211>  483
<212>  PRT
<213>  Caenorhabditis elegans

<400>  65

Met Leu Pro Arg Leu Ala Lys Ser Ser Leu Ile Gln Gln Val Arg Gly 
1               5                   10                  15      


Val Ser Ala Ile Ala Asn Ala Glu Pro Ser Gly Pro Ser Ile Ser Thr 
            20                  25                  30          


Ser Ile Pro Gly Pro Lys Ser Lys Ala Leu Lys Gln Glu Met Asp Lys 
        35                  40                  45              


Val His Gln Thr Thr Ser Val Arg Phe His Val Asp Tyr Glu Lys Ser 
    50                  55                  60                  


Phe Gly Asn Tyr Val Val Asp Ala Asp Gly Asn Ala Leu Leu Asp Val 
65                  70                  75                  80  


Tyr Thr Gln Ile Ser Ser Leu Pro Leu Gly Tyr Asn His Pro Asp Leu 
                85                  90                  95      


Val Lys Val Ala Ser Gln Pro His Leu Ile Thr Ser Leu Val Ser Arg 
            100                 105                 110         


Pro Ala Leu Gly Ser Phe Pro Arg Thr Asp Phe Ala Asp Gly Ile Ser 
        115                 120                 125             


His Ala Leu Thr Ser Ile Ala Pro Lys Gly Leu Lys Ala Val Gln Thr 
    130                 135                 140                 


Met Leu Cys Gly Thr Ser Ala Asn Glu Asn Ala Ile Lys Thr Ala Phe 
145                 150                 155                 160 


Ile Trp Tyr Gln Ala Gln Arg Arg Gly Gly Leu Gly Pro Asp Ala Leu 
                165                 170                 175     


His Leu Glu Ser Cys Met Asn Gln Gln Lys Pro Gly Thr Pro Asn Leu 
            180                 185                 190         


Ser Val Met Gly Phe Glu Gly Ala Phe His Gly Arg Ser Leu Cys Met 
        195                 200                 205             


Leu Ser Val Thr Arg Ser Lys Pro Ile His Lys Val Asp Ile Pro Ala 
    210                 215                 220                 


Phe Asp Trp Pro Ile Ala Lys Phe Pro Arg Tyr Lys Tyr Pro Leu Asp 
225                 230                 235                 240 


Gln Asn Val Ala Tyr Asn Lys Lys Gln Asp Gln Glu Cys Leu Ala Asp 
                245                 250                 255     


Val Glu Ala Lys Ile Ser Glu Trp Lys Arg Arg Asp Asn Asp Val Ala 
            260                 265                 270         


Ala Ile Ile Val Glu Pro Ile Gln Ala Glu Gly Gly Asp His Tyr Gly 
        275                 280                 285             


Ser Pro Ala Phe Phe Gln Gly Leu Arg Asp Ile Thr Ser Lys His Gly 
    290                 295                 300                 


Ile Val Phe Ile Val Asp Glu Val Gln Thr Gly Gly Gly Ala Thr Gly 
305                 310                 315                 320 


Asp Ile Trp Ala His Asp His Trp Asn Leu Ser Ser Pro Pro Asp Met 
                325                 330                 335     


Val Thr Phe Ser Lys Lys Leu Leu Thr Gly Gly Tyr Phe Tyr Gly Glu 
            340                 345                 350         


His Leu Arg Val Lys Glu Ala Tyr Arg Ile Tyr Asn Thr Trp Met Gly 
        355                 360                 365             


Asp Pro Thr Lys Leu Leu Leu Leu Glu Lys Ala Val Glu Val Ile Lys 
    370                 375                 380                 


Arg Asp Gly Leu Ile Glu Gln Ser Arg Glu Val Gly Ala Glu Phe Gln 
385                 390                 395                 400 


Lys Arg Leu Gly Glu Leu Gln Ala Ser Ser Gly Gly Lys Leu Asp Gln 
                405                 410                 415     


Ala Arg Gly Arg Gly Thr Phe Ala Ala Val Asp Phe Pro Ser Gly Ser 
            420                 425                 430         


Leu Arg Asp Lys Phe Val Asp Leu Ala Ile Ser Asn Gly Leu His Cys 
        435                 440                 445             


Gly Gly Cys Gly Asp Arg Ser Leu Arg Phe Arg Pro Ser Leu Val Tyr 
    450                 455                 460                 


Thr Lys Lys His Leu Asp Leu Thr Phe Asp Leu Leu Asp Lys Thr Leu 
465                 470                 475                 480 


Lys Gly Leu 
            


<210>  66
<211>  498
<212>  PRT
<213>  Emericella nidulans

<400>  66

Met Ala Ser Ala Phe Arg Ser Ser Leu Lys Leu Arg Ala Ser Ala Arg 
1               5                   10                  15      


Leu Pro Ala Val Arg Thr Ile Thr Thr Thr Pro Arg Leu Arg Ala Ala 
            20                  25                  30          


Glu Lys Pro Tyr Phe Pro Asn Glu Pro Thr Ala Pro Lys Leu Ala Thr 
        35                  40                  45              


Ala Ile Pro Gly Pro Lys Asn Lys Ala Ala Ser Glu Gln Leu Asn Glu 
    50                  55                  60                  


Val Phe Asp Val Arg Ser Leu Asn Met Leu Ala Asp Tyr Thr Lys Ser 
65                  70                  75                  80  


Val Gly Asn Tyr Ile Ala Asp Leu Asp Gly Asn Met Leu Leu Asp Val 
                85                  90                  95      


Tyr Ala Gln Ile Ala Ser Ile Pro Val Gly Tyr Asn Asn Pro His Leu 
            100                 105                 110         


Leu Lys Val Ala Ala Ser Pro Glu Met Ala Thr Ser Leu Ile Asn Arg 
        115                 120                 125             


Pro Ala Leu Gly Asn Phe Pro Ser Ala Asp Trp Ala His Ile Leu Lys 
    130                 135                 140                 


Thr Gly Ile Leu Lys Val Ala Pro Lys Gly Leu Asp Gln Val Phe Thr 
145                 150                 155                 160 


Ala Met Ala Gly Ser Asp Ala Asn Glu Thr Ala Tyr Lys Ala Ala Phe 
                165                 170                 175     


Met Tyr Tyr Arg Gln Gln Gln Arg Gly Gly Pro Glu Lys Glu Phe Thr 
            180                 185                 190         


Glu Glu Glu Ile Gln Ser Ser Met Leu Asn Gln Thr Pro Gly Ser Pro 
        195                 200                 205             


Gln Leu Ser Ile Met Ser Phe Lys Ala Gly Phe His Gly Arg Leu Phe 
    210                 215                 220                 


Gly Ser Leu Ser Thr Thr Arg Ser Lys Pro Ile His Lys Leu Asp Ile 
225                 230                 235                 240 


Pro Ala Phe Asp Trp Pro Gln Ala Pro Phe Pro Ser Leu Lys Tyr Pro 
                245                 250                 255     


Leu Glu Glu His Ala Lys Glu Asn Ala Glu Glu Glu Gln Arg Cys Leu 
            260                 265                 270         


Gln Glu Ala Glu Arg Leu Ile Lys Glu Trp His Asn Pro Val Ala Ala 
        275                 280                 285             


Ile Ile Val Glu Pro Ile Gln Ser Glu Gly Gly Asp Asn His Ala Ser 
    290                 295                 300                 


Pro Ala Phe Phe Arg Gly Leu Arg Glu Ile Thr Lys Arg Asn Asn Val 
305                 310                 315                 320 


Leu Phe Ile Val Asp Glu Val Gln Thr Gly Val Gly Ala Thr Gly Lys 
                325                 330                 335     


Phe Trp Ala His Asp His Trp Asn Leu Glu Thr Pro Pro Asp Met Val 
            340                 345                 350         


Thr Phe Ser Lys Lys Ala Gln Thr Ala Gly Tyr Tyr Phe Gly Asn Pro 
        355                 360                 365             


Ala Leu Arg Pro Asn Lys Pro Tyr Arg Gln Phe Asn Thr Trp Met Gly 
    370                 375                 380                 


Asp Pro Ser Arg Ala Leu Ile Phe Arg Gly Ile Ile Glu Glu Ile Glu 
385                 390                 395                 400 


Arg Leu Phe Leu Val Glu Asn Thr Ala Ala Thr Gly Asp Tyr Leu Tyr 
                405                 410                 415     


Ser Gly Leu Glu Arg Leu Ala Lys Gln Tyr Pro Glu His Leu Gln Asn 
            420                 425                 430         


Leu Arg Gly Lys Gly Gln Gly Thr Phe Ile Ala Trp Asp Thr Pro Lys 
        435                 440                 445             


Arg Asp Glu Phe Leu Val Lys Gly Lys Gly Val Gly Ile Asn Ile Gly 
    450                 455                 460                 


Gly Ser Gly Gln Asn Ala Val Arg Leu Arg Pro Met Leu Ile Phe Gln 
465                 470                 475                 480 


Lys His His Ala Asp Ile Leu Leu Glu Ser Ile Glu Lys Ile Ile Lys 
                485                 490                 495     


Gln Leu 
        


<210>  67
<211>  509
<212>  PRT
<213>  Ustilago maydis

<400>  67

Met Ile Ser Ser Lys Ala Thr Ser Ala Ala Arg Ala Cys Ala Arg Thr 
1               5                   10                  15      


Ser Arg Val Met Gln Gln Gln Gln Arg Arg Leu Leu Ala Thr Val Val 
            20                  25                  30          


Ser Ser Ser Ser Leu Phe Pro Gly Glu Pro Ser Ser Pro His Val Val 
        35                  40                  45              


Thr Ser Gln Ile Pro Gly Pro Lys Ser Lys Glu Leu Ser Asp Arg Ile 
    50                  55                  60                  


Gly Thr Phe Gln Glu Asn Arg Thr His Gly Phe Val Val Asp Tyr Ala 
65                  70                  75                  80  


Lys Ser Gln Gly Asn Trp Ile Ala Asp Ala Asp Gly Asn Val Leu Leu 
                85                  90                  95      


Asp Met Phe Ala Gln Ile Ala Ser Ile Ala Ile Gly Tyr Asn Asn Pro 
            100                 105                 110         


Asp Leu Leu Ala Leu Ala Lys Thr Asp Glu Phe Ile Thr Ala Thr Met 
        115                 120                 125             


Asn Arg Ala Ala Leu Gly Ser Phe Pro Pro Thr Asn Trp Gln Glu Leu 
    130                 135                 140                 


Val Glu Thr Ser Phe Gly Thr Val Lys Pro Asp Gly Leu Asn Asn Ile 
145                 150                 155                 160 


Phe Thr Ala Met Cys Gly Ser Cys Ala Asn Glu Asn Ala Phe Lys Ala 
                165                 170                 175     


Ser Phe Met Ala Tyr Arg Ala Arg Glu Arg Gly Glu Lys Ala Glu Phe 
            180                 185                 190         


Thr Pro Glu Glu Met Ser Ser Cys Met Lys Asn Gln Ser Pro Gly Ser 
        195                 200                 205             


Pro Asp Leu Ser Ile Leu Ser Phe Thr Ser Ala Phe His Gly Arg Leu 
    210                 215                 220                 


Phe Gly Ser Leu Ser Ala Thr Arg Ser Lys Ala Ile His Lys Leu Asp 
225                 230                 235                 240 


Ile Pro Ser Phe Asn Trp Pro Val Val Glu Trp Pro Asp Val Lys Tyr 
                245                 250                 255     


Pro Phe Ala Gln Asn Ser Arg Glu Asn Ala Glu Ala Glu Lys Val Ala 
            260                 265                 270         


Leu Ala Ala Val Glu Glu Ala Ile Val Ser Ser Lys Lys Thr Gly Ser 
        275                 280                 285             


Ser Tyr Gly Pro Val Ala Ala Leu Ile Val Glu Pro Ile Gln Ser Glu 
    290                 295                 300                 


Gly Gly Asp Asn His Ala Ser Pro Ala Phe Phe Gln Gly Leu Arg Asp 
305                 310                 315                 320 


Val Thr Lys Lys His Gly Val Phe Met Ile Val Asp Glu Val Gln Thr 
                325                 330                 335     


Gly Val Gly Ala Thr Gly Ala Phe Trp Ala His Ser Lys Trp Asn Leu 
            340                 345                 350         


Thr Ser Pro Pro Asp Phe Val Thr Phe Ser Lys Lys Met Gln Ala Ala 
        355                 360                 365             


Gly Phe Tyr His Asn Ile Glu Thr Arg Pro Ser Leu Pro Tyr Arg Asn 
    370                 375                 380                 


Tyr Asn Thr Trp Met Gly Asp Pro Ala Arg Thr Leu Gln Ala Arg Gln 
385                 390                 395                 400 


Ile Ile Arg Thr Ile Gln Asp His Asn Leu Ile Gln Lys Thr Asp Lys 
                405                 410                 415     


Val Gly Asn Tyr Ile Tyr Glu Lys Leu Phe Asp Leu Ile Glu Asn Gly 
            420                 425                 430         


Ala Gly Arg Gly Lys Ile Glu Lys Leu Arg Gly Glu Asn Ala Gly Thr 
        435                 440                 445             


Phe Leu Ala Phe Asp Gly Arg Thr Ala Lys Val Arg Asp Gln Leu Ile 
    450                 455                 460                 


Met Glu Met Arg Lys Leu Gly Val His Met Gly Gly Cys Gly Asp Lys 
465                 470                 475                 480 


Ala Leu Arg Leu Arg Pro Met Leu Val Phe Glu Gln Lys His Ala Asp 
                485                 490                 495     


Ile Phe Leu Asp Lys Leu Glu Thr Ala Leu Gly Gln Leu 
            500                 505                 


<210>  68
<211>  472
<212>  PRT
<213>  Kluyveromyces lactis

<400>  68

Met Ser Val Ala Ala Lys Tyr Tyr Pro Asn Glu Pro Thr Glu Pro Lys 
1               5                   10                  15      


Val Val Thr Ser Glu Ile Pro Gly Pro Glu Ser Lys Ala Lys Val Ala 
            20                  25                  30          


Ser Leu Gly Glu Val Phe Asp Ser Arg Pro Ala Tyr Phe Val Ala Asp 
        35                  40                  45              


Tyr Ala Lys Ser Ser Gly Asn Tyr Ile Val Asp Val Asp Gly Asn Lys 
    50                  55                  60                  


Phe Leu Asp Val Tyr Ala Gln Ile Ser Ser Ile Ala Leu Gly Tyr Asn 
65                  70                  75                  80  


Asn Pro Ala Leu Ile Glu Ala Ala Lys Ser Asp Lys Met Ile Arg Ala 
                85                  90                  95      


Leu Val Asp Arg Pro Ala Leu Gly Asn Phe Pro Gly Ala Asp Leu Glu 
            100                 105                 110         


Asp Ile Leu Lys Gln Leu Leu Lys Phe Ala Pro Lys Gly Gln Asn Lys 
        115                 120                 125             


Ile Trp Ser Gly Leu Ser Gly Ala Asp Ala Asn Glu Leu Ala Phe Lys 
    130                 135                 140                 


Ala Ala Phe Met Tyr Tyr Arg Gln Leu Gln Arg Gly Gly His Gly Ile 
145                 150                 155                 160 


Asp Phe Ser Glu Glu Glu Asn Ser Ser Val Met Glu Asn Thr Ser Pro 
                165                 170                 175     


Gly Ser Pro Gln Leu Ala Val Leu Ser Phe Lys Lys Ala Phe His Gly 
            180                 185                 190         


Arg Leu Phe Ala Ser Gly Ser Ser Thr Cys Ser Lys Pro Ile His Lys 
        195                 200                 205             


Leu Asp Phe Pro Ala Phe Asn Trp Pro His Gly Glu Tyr Pro Val Tyr 
    210                 215                 220                 


Lys Tyr Pro Leu Ser Glu Asn Glu Glu Glu Asn Lys Lys Glu Asp Asp 
225                 230                 235                 240 


Arg Cys Leu Ala Ile Val Glu Asp Leu Ile Lys Ser Trp Pro Thr Pro 
                245                 250                 255     


Val Ala Ala Leu Ile Ile Glu Pro Ile Gln Ser Glu Gly Gly Asp Asn 
            260                 265                 270         


His Ala Ser Lys Tyr Phe Leu Gln Ser Leu Arg Asp Leu Thr Ser Lys 
        275                 280                 285             


Tyr Asn Val Val Tyr Ile Ile Asp Glu Val Gln Thr Gly Val Gly Ala 
    290                 295                 300                 


Thr Gly Lys Phe Trp Cys His Glu Trp Ala Asp Ile Gln Pro Pro Val 
305                 310                 315                 320 


Asp Leu Val Thr Phe Ser Lys Lys Phe Gln Ser Ala Gly Tyr Trp Phe 
                325                 330                 335     


His Asp Asp Arg Phe Ile Pro Asn Lys Ala Tyr Arg Gln Phe Asn Thr 
            340                 345                 350         


Trp Cys Gly Asp Pro Ala Arg Met Ile Ile Ala Gly Ala Ile Gly Gln 
        355                 360                 365             


Glu Ile Val Asp Asn Asn Leu Val Asp Gln Cys Ala Arg Val Gly Asp 
    370                 375                 380                 


Tyr Leu Phe Glu Lys Leu Glu Lys Leu Gln Ala Lys Tyr Pro Thr Arg 
385                 390                 395                 400 


Leu Ile Asn Leu Arg Gly Lys Asn Arg Gly Thr Phe Ile Ala Phe Asp 
                405                 410                 415     


Leu Glu Thr Ser Ala Glu Arg Asp Gln Leu Leu Lys Leu Leu Lys Ser 
            420                 425                 430         


Asn Gly Cys Asn Val Gly Gly Cys Ala Glu Lys Ser Val Arg Leu Arg 
        435                 440                 445             


Pro Ser Leu Thr Phe Glu Glu Lys His Ala Asp Ile Phe Val Asp Ala 
    450                 455                 460                 


Leu Glu Lys Ser Ile Gly Gln Leu 
465                 470         


<210>  69
<211>  436
<212>  PRT
<213>  Bacillus subtilis

<400>  69

Met Ser Gln Thr Thr Ala Ser Ile Thr Thr Ala Gln Trp Gln Gln Lys 
1               5                   10                  15      


Arg Asp Gln Phe Val Ser Lys Gly Val Ser Asn Gly Asn Arg Ser Leu 
            20                  25                  30          


Ala Val Lys Gly Glu Gly Ala Glu Leu Tyr Asp Leu Asp Gly Arg Arg 
        35                  40                  45              


Phe Ile Asp Phe Ala Gly Ala Ile Gly Thr Leu Asn Val Gly His Ser 
    50                  55                  60                  


His Pro Lys Val Val Glu Ala Val Lys Arg Gln Ala Glu Glu Leu Ile 
65                  70                  75                  80  


His Pro Gly Phe Asn Val Met Met Tyr Pro Thr Tyr Ile Glu Leu Ala 
                85                  90                  95      


Glu Lys Leu Cys Gly Ile Ala Pro Gly Ser His Glu Lys Lys Ala Ile 
            100                 105                 110         


Phe Leu Asn Ser Gly Ala Glu Ala Val Glu Asn Ala Val Lys Ile Ala 
        115                 120                 125             


Arg Lys Tyr Thr Lys Arg Gln Gly Val Val Ser Phe Thr Arg Gly Phe 
    130                 135                 140                 


His Gly Arg Thr Asn Met Thr Met Ser Met Thr Ser Lys Val Lys Pro 
145                 150                 155                 160 


Tyr Lys Phe Gly Phe Gly Pro Phe Ala Pro Glu Val Tyr Gln Ala Pro 
                165                 170                 175     


Phe Pro Tyr Tyr Tyr Gln Lys Pro Ala Gly Met Ser Asp Glu Ser Tyr 
            180                 185                 190         


Asp Asp Met Val Ile Gln Ala Phe Asn Asp Phe Phe Ile Ala Ser Val 
        195                 200                 205             


Ala Pro Glu Thr Val Ala Cys Val Val Met Glu Pro Val Gln Gly Glu 
    210                 215                 220                 


Gly Gly Phe Ile Ile Pro Ser Lys Arg Phe Val Gln His Val Ala Ser 
225                 230                 235                 240 


Phe Cys Lys Glu His Gly Ile Val Phe Val Ala Asp Glu Ile Gln Thr 
                245                 250                 255     


Gly Phe Ala Arg Thr Gly Thr Tyr Phe Ala Ile Glu His Phe Asp Val 
            260                 265                 270         


Val Pro Asp Leu Ile Thr Val Ser Lys Ser Leu Ala Ala Gly Leu Pro 
        275                 280                 285             


Leu Ser Gly Val Ile Gly Arg Ala Glu Met Leu Asp Ala Ala Ala Pro 
    290                 295                 300                 


Gly Glu Leu Gly Gly Thr Tyr Ala Gly Ser Pro Leu Gly Cys Ala Ala 
305                 310                 315                 320 


Ala Leu Ala Val Leu Asp Ile Ile Glu Glu Glu Gly Leu Asn Glu Arg 
                325                 330                 335     


Ser Glu Glu Ile Gly Lys Ile Ile Glu Asp Lys Ala Tyr Glu Trp Lys 
            340                 345                 350         


Gln Glu Phe Pro Phe Ile Gly Asp Ile Arg Arg Leu Gly Ala Met Ala 
        355                 360                 365             


Ala Ile Glu Ile Val Lys Asp Pro Asp Thr Arg Glu Pro Asp Lys Thr 
    370                 375                 380                 


Lys Ala Ala Ala Ile Ala Ala Tyr Ala Asn Gln Asn Gly Leu Leu Leu 
385                 390                 395                 400 


Leu Thr Ala Gly Ile Asn Gly Asn Ile Ile Arg Phe Leu Thr Pro Leu 
                405                 410                 415     


Val Ile Ser Asp Ser Leu Leu Asn Glu Gly Leu Ser Ile Leu Glu Ala 
            420                 425                 430         


Gly Leu Arg Ala 
        435     


<210>  70
<211>  495
<212>  PRT
<213>  Dictyostelium discoideum

<400>  70

Met Ser Ser Ser Arg Leu Ile Lys Cys Leu Ser Ser Asn Asn Tyr Ile 
1               5                   10                  15      


Val Arg Ser Phe Ser Lys Ser Ser Ile Pro Thr Thr Pro Thr Pro Asp 
            20                  25                  30          


Phe Pro Gly Glu Tyr Lys Glu Pro Ile Val Lys Thr Gln Ile Pro Gly 
        35                  40                  45              


Pro Gln Ser Lys Ala Leu Ile Glu Arg Leu Asn Lys Leu Gln Asp Pro 
    50                  55                  60                  


Arg Ala Ala His Phe Phe Ala Asp Tyr Ala Asn Ser Arg Gly Asn Tyr 
65                  70                  75                  80  


Ile Ser Asp Val Asp Gly Asn Ile Leu Leu Asp Leu Tyr Cys Gln Ile 
                85                  90                  95      


Ala Ser Ile Pro Ile Gly Tyr Asn Asn Pro Glu Leu Ile Lys Ala Ala 
            100                 105                 110         


Lys Ser Asp Arg Trp Val Ser Ala Ile Ile Asn Arg Pro Ser Leu Gly 
        115                 120                 125             


Val Leu Pro Pro Lys Asp Trp Pro Ala Leu Ile Glu Asn Ser Phe Met 
    130                 135                 140                 


Gln Val Ser Pro Lys Gly Leu Asn Gln Val Phe Thr Ala Met Cys Gly 
145                 150                 155                 160 


Ser Cys Ala Asn Glu Cys Ala Tyr Lys Ala Val Phe Met His Tyr Gln 
                165                 170                 175     


His Val Lys Arg Gly Gly Lys Pro Phe Thr Pro Glu Glu Leu Ser Ser 
            180                 185                 190         


Cys Met Lys Asn Gln Glu Pro Gly Ser Pro Ser Leu Ser Ile Leu Ser 
        195                 200                 205             


Phe Lys Lys Gly Phe His Gly Arg Thr Phe Gly Thr Leu Ser Thr Thr 
    210                 215                 220                 


Arg Ser Lys Ala Ile His Lys Leu Asp Ile Pro Ala Phe Asp Trp Pro 
225                 230                 235                 240 


Ala Ala Thr Phe Pro Asp Leu Lys Tyr Pro Leu Ala Glu His Ala Lys 
                245                 250                 255     


Glu Asn Arg Glu Ile Glu Asp Arg Cys Leu Gln Glu Val Glu Gln Leu 
            260                 265                 270         


Ile Lys Thr Trp His Ile Pro Val Ala Gly Ile Ile Val Glu Pro Ile 
        275                 280                 285             


Gln Ala Glu Gly Gly Asp Asn Tyr Ala Thr Pro Tyr Phe Phe Gln Gly 
    290                 295                 300                 


Leu Arg Asp Ile Thr Lys Lys His Gly Val Ser Met Ile Val Asp Glu 
305                 310                 315                 320 


Val Gln Thr Gly Met Gly Ala Thr Gly Lys Phe Trp Ala His Glu His 
                325                 330                 335     


Trp Asn Leu Thr Ser Pro Pro Asp Ile Val Thr Phe Ser Lys Lys Met 
            340                 345                 350         


Gln Ala Ala Gly Phe Tyr His Asn Leu Asp Tyr Arg Pro Ser Glu Ser 
        355                 360                 365             


Tyr Arg Asn Phe Asn Thr Trp Met Gly Asp Pro Val Arg Ala Leu Glu 
    370                 375                 380                 


Leu Glu Val Val Ile Gly Glu Ile Lys Lys Asn His Leu Leu Asp Asn 
385                 390                 395                 400 


Val Val Ile Thr Gly Asn Tyr Leu Lys Asp Gly Leu Phe Asp Ile Ala 
                405                 410                 415     


Ala Arg Tyr Pro Gly Leu Ile Gln Asn Ile Arg Gly Glu Gly Thr Phe 
            420                 425                 430         


Leu Ala Ile Asp Phe Pro Thr Pro Ala Glu Arg Asp Arg Val Ile Ser 
        435                 440                 445             


His Ile Arg Leu Leu Gly Val Glu Met Gly Gly Cys Gly Glu Arg Ser 
    450                 455                 460                 


Ile Arg Phe Arg Pro Met Leu Val Cys Gln Pro Ser His Ile Asn Gln 
465                 470                 475                 480 


Phe Leu Asn Arg Phe Asp Gln Thr Met Lys Glu Leu Tyr Lys Asn 
                485                 490                 495 


<210>  71
<211>  449
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  71

Met Ala Ser Leu Gln Gln Ser Arg Arg Leu Val Thr Glu Ile Pro Gly 
1               5                   10                  15      


Pro Ala Ser Gln Ala Leu Thr His Arg Arg Ala Ala Ala Val Ser Ser 
            20                  25                  30          


Gly Val Gly Val Thr Leu Pro Val Phe Val Ala Arg Ala Gly Gly Gly 
        35                  40                  45              


Ile Val Glu Asp Val Asp Gly Asn Arg Leu Ile Asp Leu Gly Ser Gly 
    50                  55                  60                  


Ile Ala Val Thr Thr Ile Gly Asn Ser Ser Pro Arg Val Val Asp Ala 
65                  70                  75                  80  


Val Arg Thr Gln Val Ala Glu Phe Thr His Thr Cys Phe Met Val Thr 
                85                  90                  95      


Pro Tyr Glu Gly Tyr Val Ala Val Ala Glu Gln Leu Asn Arg Ile Thr 
            100                 105                 110         


Pro Gly Ser Gly Pro Lys Arg Ser Val Leu Phe Asn Ser Gly Ala Glu 
        115                 120                 125             


Ala Val Glu Asn Ala Val Lys Ile Ala Arg Ser Tyr Thr Gly Lys Pro 
    130                 135                 140                 


Ala Val Val Ala Phe Asp His Ala Tyr His Gly Arg Thr Asn Leu Thr 
145                 150                 155                 160 


Met Ala Leu Thr Ala Lys Ser Met Pro Tyr Lys Ser Gly Phe Gly Pro 
                165                 170                 175     


Phe Ala Pro Glu Ile Tyr Arg Ala Pro Leu Ser Tyr Pro Tyr Arg Asp 
            180                 185                 190         


Gly Leu Leu Asp Lys Gln Leu Ala Thr Asn Gly Glu Leu Ala Ala Ala 
        195                 200                 205             


Arg Ala Ile Gly Val Ile Asp Lys Gln Val Gly Ala Asn Asn Leu Ala 
    210                 215                 220                 


Ala Leu Val Ile Glu Pro Ile Gln Gly Glu Gly Gly Phe Ile Val Pro 
225                 230                 235                 240 


Ala Glu Gly Phe Leu Pro Ala Leu Leu Asp Trp Cys Arg Lys Asn His 
                245                 250                 255     


Val Val Phe Ile Ala Asp Glu Val Gln Thr Gly Phe Ala Arg Thr Gly 
            260                 265                 270         


Ala Met Phe Ala Cys Glu His Glu Gly Pro Asp Gly Leu Glu Pro Asp 
        275                 280                 285             


Leu Ile Cys Thr Ala Lys Gly Ile Ala Asp Gly Leu Pro Leu Ser Ala 
    290                 295                 300                 


Val Thr Gly Arg Ala Glu Ile Met Asn Ala Pro His Val Gly Gly Leu 
305                 310                 315                 320 


Gly Gly Thr Phe Gly Gly Asn Pro Val Ala Cys Ala Ala Ala Leu Ala 
                325                 330                 335     


Thr Ile Ala Thr Ile Glu Ser Asp Gly Leu Ile Glu Arg Ala Arg Gln 
            340                 345                 350         


Ile Glu Arg Leu Val Thr Asp Arg Leu Thr Thr Leu Gln Ala Val Asp 
        355                 360                 365             


Asp Arg Ile Gly Asp Val Arg Gly Arg Gly Ala Met Ile Ala Val Glu 
    370                 375                 380                 


Leu Val Lys Ser Gly Thr Thr Glu Pro Asp Ala Gly Leu Thr Glu Arg 
385                 390                 395                 400 


Leu Ala Thr Ala Ala His Ala Ala Gly Val Ile Ile Leu Thr Cys Gly 
                405                 410                 415     


Met Phe Gly Asn Ile Ile Arg Leu Leu Pro Pro Leu Thr Ile Gly Asp 
            420                 425                 430         


Glu Leu Leu Ser Glu Gly Leu Asp Ile Val Cys Ala Ile Leu Ala Asp 
        435                 440                 445             


Leu 
    


<210>  72
<211>  446
<212>  PRT
<213>  Mycobacterium leprae

<400>  72

Met Thr Ser Val Glu Gln Ser Arg Gln Leu Val Thr Glu Ile Pro Gly 
1               5                   10                  15      


Pro Val Ser Leu Glu Leu Ala Lys Arg Leu Asn Ala Ala Val Pro Arg 
            20                  25                  30          


Gly Val Gly Val Thr Leu Pro Val Phe Val Thr Arg Ala Ala Gly Gly 
        35                  40                  45              


Val Ile Glu Asp Val Asp Gly Asn Arg Leu Ile Asp Leu Gly Ser Gly 
    50                  55                  60                  


Ile Ala Val Thr Thr Ile Gly Asn Ser Ser Pro Arg Val Val Asp Ala 
65                  70                  75                  80  


Val Arg Ala Gln Val Ala Asp Phe Thr His Thr Cys Phe Ile Ile Thr 
                85                  90                  95      


Pro Tyr Glu Glu Tyr Val Ala Val Thr Glu Gln Leu Asn Arg Ile Thr 
            100                 105                 110         


Pro Gly Ser Gly Glu Lys Arg Ser Val Leu Phe Asn Ser Gly Ala Glu 
        115                 120                 125             


Ala Val Glu Asn Ser Ile Lys Val Ala Arg Ser Tyr Thr Arg Lys Pro 
    130                 135                 140                 


Ala Val Val Ala Phe Asp His Ala Tyr His Gly Arg Thr Asn Leu Thr 
145                 150                 155                 160 


Met Ala Leu Thr Ala Lys Ser Met Pro Tyr Lys Ser Gly Phe Gly Pro 
                165                 170                 175     


Phe Ala Pro Glu Ile Tyr Arg Ala Pro Leu Ser Tyr Pro Tyr Arg Asp 
            180                 185                 190         


Gly Leu Leu Asn Lys Asp Leu Ala Thr Asp Gly Lys Leu Ala Gly Ala 
        195                 200                 205             


Arg Ala Ile Asn Val Ile Glu Lys Gln Val Gly Ala Asp Asp Leu Ala 
    210                 215                 220                 


Ala Val Ile Ile Glu Pro Ile Gln Gly Glu Gly Gly Phe Ile Val Pro 
225                 230                 235                 240 


Ala Glu Gly Phe Leu Ala Thr Leu Leu Asp Trp Cys Arg Lys Asn Asn 
                245                 250                 255     


Val Met Phe Ile Ala Asp Glu Val Gln Thr Gly Phe Ala Arg Thr Gly 
            260                 265                 270         


Ala Met Phe Ala Cys Glu His Asp Gly Ile Val Pro Asp Leu Ile Cys 
        275                 280                 285             


Thr Ala Lys Gly Ile Ala Asp Gly Leu Pro Leu Ala Ala Val Thr Gly 
    290                 295                 300                 


Arg Ala Glu Ile Met Asn Ala Pro His Val Ser Gly Leu Gly Gly Thr 
305                 310                 315                 320 


Phe Gly Gly Asn Pro Val Ala Cys Ala Ala Ala Leu Ala Thr Ile Thr 
                325                 330                 335     


Thr Ile Glu Asn Asp Gly Leu Ile Gln Arg Ala Gln Gln Ile Glu Arg 
            340                 345                 350         


Leu Ile Thr Asp Arg Leu Leu Arg Leu Gln Asp Ala Asp Asp Arg Ile 
        355                 360                 365             


Gly Asp Val Arg Gly Arg Gly Ala Met Ile Ala Val Glu Leu Val Lys 
    370                 375                 380                 


Ser Gly Thr Ala Glu Pro Asp Pro Glu Leu Thr Glu Lys Val Ala Thr 
385                 390                 395                 400 


Ala Ala His Ala Thr Gly Val Ile Ile Leu Thr Cys Gly Met Phe Gly 
                405                 410                 415     


Asn Ile Ile Arg Leu Leu Pro Pro Leu Thr Ile Ser Asp Glu Leu Leu 
            420                 425                 430         


Ala Glu Gly Leu Asp Ile Leu Ser Arg Ile Leu Gly Asp Phe 
        435                 440                 445     


<210>  73
<211>  449
<212>  PRT
<213>  Mycobacterium bovis

<400>  73

Met Ala Ser Leu Gln Gln Ser Arg Arg Leu Val Thr Glu Ile Pro Gly 
1               5                   10                  15      


Pro Ala Ser Gln Ala Leu Thr His Arg Arg Ala Ala Ala Val Ser Ser 
            20                  25                  30          


Gly Val Gly Val Thr Leu Pro Val Phe Val Ala Arg Ala Gly Gly Gly 
        35                  40                  45              


Ile Val Glu Asp Val Asp Gly Asn Arg Leu Ile Asp Leu Gly Ser Gly 
    50                  55                  60                  


Ile Ala Val Thr Thr Ile Gly Asn Ser Ser Pro Arg Val Val Asp Ala 
65                  70                  75                  80  


Val Arg Thr Gln Val Ala Glu Phe Thr His Thr Cys Phe Met Val Thr 
                85                  90                  95      


Pro Tyr Glu Gly Tyr Val Ala Val Ala Glu Gln Leu Asn Arg Ile Thr 
            100                 105                 110         


Pro Gly Ser Gly Pro Lys Arg Ser Val Leu Phe Asn Ser Gly Ala Glu 
        115                 120                 125             


Ala Val Glu Asn Ala Val Lys Ile Ala Arg Ser Tyr Thr Gly Lys Pro 
    130                 135                 140                 


Ala Val Val Ala Phe Asp His Ala Tyr His Gly Arg Thr Asn Leu Thr 
145                 150                 155                 160 


Met Ala Leu Thr Ala Lys Ser Met Pro Tyr Lys Ser Gly Phe Gly Pro 
                165                 170                 175     


Phe Ala Pro Glu Ile Tyr Arg Ala Pro Leu Ser Tyr Pro Tyr Arg Asp 
            180                 185                 190         


Gly Leu Leu Asp Lys Gln Leu Ala Thr Asn Gly Glu Leu Ala Ala Ala 
        195                 200                 205             


Arg Ala Ile Gly Val Ile Asp Lys Gln Val Gly Ala Asn Asn Leu Ala 
    210                 215                 220                 


Ala Leu Val Ile Glu Pro Ile Gln Gly Glu Gly Gly Phe Ile Val Pro 
225                 230                 235                 240 


Ala Glu Gly Phe Leu Pro Ala Leu Leu Asp Trp Cys Arg Lys Asn His 
                245                 250                 255     


Val Val Phe Ile Ala Asp Glu Val Gln Thr Gly Phe Ala Arg Thr Gly 
            260                 265                 270         


Ala Met Phe Ala Cys Glu His Glu Gly Pro Asp Gly Leu Glu Pro Asp 
        275                 280                 285             


Leu Ile Cys Thr Ala Lys Gly Ile Ala Asp Gly Leu Pro Leu Ser Ala 
    290                 295                 300                 


Val Thr Gly Arg Ala Glu Ile Met Asn Ala Pro His Val Gly Gly Leu 
305                 310                 315                 320 


Gly Gly Thr Phe Gly Gly Asn Pro Val Ala Cys Ala Ala Ala Leu Ala 
                325                 330                 335     


Thr Ile Ala Thr Ile Glu Ser Asp Gly Leu Ile Glu Arg Ala Arg Gln 
            340                 345                 350         


Ile Glu Arg Leu Val Thr Asp Arg Leu Thr Thr Leu Gln Ala Val Asp 
        355                 360                 365             


Asp Arg Ile Gly Asp Val Arg Gly Arg Gly Ala Met Ile Ala Val Glu 
    370                 375                 380                 


Leu Val Lys Ser Gly Thr Thr Glu Pro Asp Ala Gly Leu Thr Glu Arg 
385                 390                 395                 400 


Leu Ala Thr Ala Ala His Ala Ala Gly Val Ile Ile Leu Thr Cys Gly 
                405                 410                 415     


Met Phe Gly Asn Ile Ile Arg Leu Leu Pro Pro Leu Thr Ile Gly Asp 
            420                 425                 430         


Glu Leu Leu Ser Glu Gly Leu Asp Ile Val Cys Ala Ile Leu Ala Asp 
        435                 440                 445             


Leu 
    


<210>  74
<211>  449
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  74

Met Ala Ser Leu Gln Gln Ser Arg Arg Leu Val Thr Glu Ile Pro Gly 
1               5                   10                  15      


Pro Ala Ser Gln Ala Leu Thr His Arg Arg Ala Ala Ala Val Ser Ser 
            20                  25                  30          


Gly Val Gly Val Thr Leu Pro Val Phe Val Ala Arg Ala Gly Gly Gly 
        35                  40                  45              


Ile Val Glu Asp Val Asp Gly Asn Arg Leu Ile Asp Leu Gly Ser Gly 
    50                  55                  60                  


Ile Ala Val Thr Thr Ile Gly Asn Ser Ser Pro Arg Val Val Asp Ala 
65                  70                  75                  80  


Val Arg Thr Gln Val Ala Glu Phe Thr His Thr Cys Phe Met Val Thr 
                85                  90                  95      


Pro Tyr Glu Gly Tyr Val Ala Val Ala Glu Gln Leu Asn Arg Ile Thr 
            100                 105                 110         


Pro Gly Ser Gly Pro Lys Arg Ser Val Leu Phe Asn Ser Gly Ala Glu 
        115                 120                 125             


Ala Val Glu Asn Ala Val Lys Ile Ala Arg Ser Tyr Thr Gly Lys Pro 
    130                 135                 140                 


Ala Val Val Ala Phe Asp His Ala Tyr His Gly Arg Thr Asn Leu Thr 
145                 150                 155                 160 


Met Ala Leu Thr Ala Lys Ser Met Pro Tyr Lys Ser Gly Phe Gly Pro 
                165                 170                 175     


Phe Ala Pro Glu Ile Tyr Arg Ala Pro Leu Ser Tyr Pro Tyr Arg Asp 
            180                 185                 190         


Gly Leu Leu Asp Lys Gln Leu Ala Thr Asn Gly Glu Leu Ala Ala Ala 
        195                 200                 205             


Arg Ala Ile Gly Val Ile Asp Lys Gln Val Gly Ala Asn Asn Leu Ala 
    210                 215                 220                 


Ala Leu Val Ile Glu Pro Ile Gln Gly Glu Gly Gly Phe Ile Val Pro 
225                 230                 235                 240 


Ala Glu Gly Phe Leu Pro Ala Leu Leu Asp Trp Cys Arg Lys Asn His 
                245                 250                 255     


Val Val Phe Ile Ala Asp Glu Val Gln Thr Gly Phe Ala Arg Thr Gly 
            260                 265                 270         


Ala Met Phe Ala Cys Glu His Glu Gly Pro Asp Gly Leu Glu Pro Asp 
        275                 280                 285             


Leu Ile Cys Thr Ala Lys Gly Ile Ala Asp Gly Leu Pro Leu Ser Ala 
    290                 295                 300                 


Val Thr Gly Arg Ala Glu Ile Met Asn Ala Pro His Val Gly Gly Leu 
305                 310                 315                 320 


Gly Gly Thr Phe Gly Gly Asn Pro Val Ala Cys Ala Ala Ala Leu Ala 
                325                 330                 335     


Thr Ile Ala Thr Ile Glu Ser Asp Gly Leu Ile Glu Arg Ala Arg Gln 
            340                 345                 350         


Ile Glu Arg Leu Val Thr Asp Arg Leu Thr Thr Leu Gln Ala Val Asp 
        355                 360                 365             


Asp Arg Ile Gly Asp Val Arg Gly Arg Gly Ala Met Ile Ala Val Glu 
    370                 375                 380                 


Leu Val Lys Ser Gly Thr Thr Glu Pro Asp Ala Gly Leu Thr Glu Arg 
385                 390                 395                 400 


Leu Ala Thr Ala Ala His Ala Ala Gly Val Ile Ile Leu Thr Cys Gly 
                405                 410                 415     


Met Phe Gly Asn Ile Ile Arg Leu Leu Pro Pro Leu Thr Ile Gly Asp 
            420                 425                 430         


Glu Leu Leu Ser Glu Gly Leu Asp Ile Val Cys Ala Ile Leu Ala Asp 
        435                 440                 445             


Leu 
    


<210>  75
<211>  470
<212>  PRT
<213>  Streptomyces aizunensis

<400>  75

Met Arg Pro Met Thr Ala Lys Ile Phe Ala Val Asp Ser Val Arg Pro 
1               5                   10                  15      


Ile Asp Glu Phe Glu Gln Asp Ala Leu Arg Val Ala Asp Val Ile Arg 
            20                  25                  30          


Glu Arg Gly Val Cys Leu Gly Asp Arg Val Met Leu Lys Ala Gly Asn 
        35                  40                  45              


Ser Ala Ser Tyr Val Cys Val Leu Tyr Ala Leu Met His Ile Gly Ala 
    50                  55                  60                  


Ser Ile Val Leu Val Asp Gln Gln Glu His Lys Glu Glu Thr Arg Arg 
65                  70                  75                  80  


Ile Ala Leu Arg Thr Gly Val Lys Val Thr Phe Val Asp Asp Glu Thr 
                85                  90                  95      


Pro Ile Asp Gln Asp Ala Asp Pro Ile His Leu Tyr Glu Leu Met Val 
            100                 105                 110         


Ala Thr Gln Asn Arg Pro Pro Met Asp Ser Ala Leu Ser Phe Asp Ala 
        115                 120                 125             


Trp Gly Glu Leu Ser Asp Gly Leu Ile Met Trp Thr Ser Gly Ser Thr 
    130                 135                 140                 


Gly Ser Pro Lys Gly Val Val Lys Ser Gly Gly Lys Phe Leu Ala Asn 
145                 150                 155                 160 


Leu Arg Arg Asn Ala His Gln Val Gly His Arg Pro Asp Asp Val Leu 
                165                 170                 175     


Met Pro Leu Leu Pro Phe Ala His Gln Tyr Gly Leu Ser Met Val Leu 
            180                 185                 190         


Ile Ala Trp Leu Thr Arg Cys Ser Leu Val Ile Ala Pro Tyr Arg Arg 
        195                 200                 205             


Leu Asp Arg Ala Leu Arg Met Ala Arg Asp Ser Gly Thr Thr Val Ile 
    210                 215                 220                 


Asp Ala Thr Pro Ser Ser Tyr Arg Ser Ile Leu Gly Leu Val Thr Arg 
225                 230                 235                 240 


Lys Pro Ala Leu Arg Ala His Leu Ala Gly Thr Arg Met Phe Cys Val 
                245                 250                 255     


Gly Ala Ala Pro Leu Asp Ala Pro Leu Val Glu Ser Tyr Val Gln Glu 
            260                 265                 270         


Phe Gly Leu Pro Leu Leu Asp Ser Tyr Gly Ser Thr Glu Leu Asn Asn 
        275                 280                 285             


Ile Ala Phe Ala Thr Leu Asp Asn Pro Val Ser Cys Gly Arg Ala Met 
    290                 295                 300                 


Glu Gly Ile Gly Leu Arg Ile Val Asp Glu Asp Gly Arg Glu Val Ala 
305                 310                 315                 320 


Ala Gly Gln Pro Gly Glu Ile Glu Val Asp Thr Pro Asp Ala Leu Glu 
                325                 330                 335     


Gly Gln Ile Ala Glu Asp Gly Ser Ile Ile Pro Ala Pro Thr Gly Trp 
            340                 345                 350         


Gln Arg Thr Gly Asp Leu Gly His Leu Asp Ala Asp Gly Asn Leu Tyr 
        355                 360                 365             


Val Leu Gly Arg Lys Phe Ala Val His Arg Met Gly Tyr Thr Leu Tyr 
    370                 375                 380                 


Pro Glu Leu Ile Glu Arg Lys Val Ala Ala Glu Gly Cys Pro Thr Arg 
385                 390                 395                 400 


Ile Val Pro Leu Pro Asp Glu Leu Arg Gly Ser Gln Leu Val Phe Phe 
                405                 410                 415     


Val Glu Asp Asp Glu Gln Arg Asp Ala Gly Tyr Trp Arg Glu Arg Leu 
            420                 425                 430         


Cys Gly Leu Leu Pro Ala Phe Glu Gln Pro Asn Lys Val Val Val Leu 
        435                 440                 445             


Glu Gln Phe Pro Leu Asn Arg Asn Gly Lys Pro Asp Lys Lys Glu Leu 
    450                 455                 460                 


Thr Arg Met Ala Ala Glu 
465                 470 


<210>  76
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFP protein

<400>  76

Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
1               5                   10                  15      


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
            20                  25                  30          


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
        35                  40                  45              


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe 
    50                  55                  60                  


Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Arg 
65                  70                  75                  80  


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
                85                  90                  95      


Thr Ile Ser Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
            100                 105                 110         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
        115                 120                 125             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
    130                 135                 140                 


Tyr Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly 
145                 150                 155                 160 


Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val 
                165                 170                 175     


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
            180                 185                 190         


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser 
        195                 200                 205             


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
    210                 215                 220                 


Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235             


<210>  77
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RFP protein

<400>  77

Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe 
1               5                   10                  15      


Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe 
            20                  25                  30          


Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr 
        35                  40                  45              


Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp 
    50                  55                  60                  


Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His 
65                  70                  75                  80  


Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe 
                85                  90                  95      


Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val 
            100                 105                 110         


Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys 
        115                 120                 125             


Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly 
145                 150                 155                 160 


Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly 
                165                 170                 175     


His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val 
            180                 185                 190         


Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser 
        195                 200                 205             


His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly 
    210                 215                 220                 


Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235     


<210>  78
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GFP gene

<400>  78
atgagtaaag gagaagaact tttcactgga gttgtcccaa ttcttgttga attagatggt       60

gatgttaatg ggcacaaatt ttctgtcagt ggagagggtg aaggtgatgc aacatacgga      120

aaacttaccc ttaaatttat ttgcactact ggaaaactac ctgttccgtg gccaacactt      180

gtcactactt tctcttatgg tgttcaatgc ttttcccgtt atccggatca catgaaacgg      240

catgactttt tcaagagtgc catgcccgaa ggttatgtac aggaacgcac tatatctttc      300

aaagatgacg ggaactacaa gacgcgtgct gaagtcaagt ttgaaggtga tacccttgtt      360

aatcgtatcg agttaaaagg tattgatttt aaagaagatg gaaacattct cggacacaaa      420

ctggagtaca actataactc acacaatgta tacatcacgg cagacaaaca aaagaatgga      480

atcaaagcta acttcaaaat tcgccacaac attgaagatg gctccgttca actagcagac      540

cattatcaac aaaatactcc aattggcgat ggccctgtcc ttttaccaga caaccattac      600

ctgtccacac aatctgccct ttcgaaagat cccaacgaaa agcgtgacca catggtcctt      660

cttgagtttg taactgctgc tgggattaca catggcatgg atgagctcta caaataa         717


<210>  79
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mCherry gene

<400>  79
atggtgtcaa agggagagga agacaatatg gcgattatca aagagttcat gcgatttaag       60

gtacacatgg agggaagcgt gaatggccat gaatttgaaa tagaggggga aggggaggga      120

cgcccatacg agggcacaca aacggctaaa ttgaaagtta ctaaaggagg cccgcttcct      180

tttgcgtggg atatactttc accccaattc atgtacggtt ctaaagcata cgtcaagcac      240

ccagcagata tacctgatta cttaaagctg agctttcctg aaggctttaa atgggaacgc      300

gtaatgaact ttgaagacgg aggagtcgtc accgtaacgc aggattcttc cttacaggat      360

ggtgagttta tttataaggt aaaattacgt ggcacaaatt ttccttctga cgggcctgtc      420

atgcagaaaa aaaccatggg atgggaagcg tcttcagaaa gaatgtatcc tgaagacggg      480

gcactgaaag gagagataaa gcagcgtttg aaactgaaag atggtggcca ctacgatgcg      540

gaagtaaaaa cgacgtataa ggcaaaaaaa cccgtgcagc tacctggtgc ttataatgtg      600

aatattaaac ttgacataac gtcgcacaac gaggattaca caatcgtgga acagtacgaa      660

agggccgagg gccgccattc aacgggcggc atggatgaac tgtataagta a               711


<210>  80
<211>  1401
<212>  DNA
<213>  Escherichia coli

<400>  80
atggataaga agcaagtaac ggatttaagg tcggaactac tcgattcacg ttttggtgcg       60

aagtctattt ccactatcgc agaatcaaaa cgttttccgc tgcacgaaat gcgcgacgat      120

gtcgcattcc agattatcaa tgacgaatta tatcttgatg gcaacgctcg tcagaacctg      180

gccactttct gccagacctg ggacgacgaa aatgtccaca aattgatgga tttatccatt      240

aacaaaaact ggatcgacaa agaagaatat ccgcaatccg cagccatcga cctgcgttgc      300

gtaaatatgg ttgccgatct gtggcatgcg cctgcgccga aaaatggtca ggccgttggc      360

accaacacca ttggttcttc cgaggcctgt atgctcggcg ggatggcgat gaaatggcgt      420

tggcgcaagc gtatggaagc tgcaggcaaa ccaacggata aaccaaacct ggtgtgcggt      480

ccggtacaaa tctgctggca taaattcgcc cgctactggg atgtggagct gcgtgagatc      540

cctatgcgcc ccggtcagtt gtttatggac ccgaaacgca tgattgaagc ctgtgacgaa      600

aacaccatcg gcgtggtgcc gactttcggc gtgacctaca ctggtaacta tgagttccca      660

caaccgctgc acgatgcgct ggataaattc caggccgata ccggtatcga catcgacatg      720

cacatcgacg ctgccagcgg tggcttcctg gcaccgttcg tcgccccgga tatcgtctgg      780

gacttccgcc tgccgcgtgt gaaatcgatc agtgcttcag gccataaatt cggtctggct      840

ccgctgggct gcggctgggt tatctggcgt gacgaagaag cgctgccgca ggaactggtg      900

ttcaacgttg actacctggg tggtcaaatt ggtacttttg ccatcaactt ctcccgcccg      960

gcgggtcagg taattgcaca gtactatgaa ttcctgcgcc tcggtcgtga aggctatacc     1020

aaagtacaga acgcctctta ccaggttgcc gcttatctgg cggatgaaat cgccaaactg     1080

gggccgtatg agttcatctg tacgggtcgc ccggacgaag gcatcccggc ggtttgcttc     1140

aaactgaaag atggtgaaga tccgggatac accctgtatg acctctctga acgtctgcgt     1200

ctgcgcggct ggcaggttcc ggccttcact ctcggcggtg aagccaccga catcgtggtg     1260

atgcgcatta tgtgtcgtcg cggcttcgaa atggactttg ctgaactgtt gctggaagac     1320

tacaaagcct ccctgaaata tctcagcgat cacccgaaac tgcagggtat tgcccaacag     1380

aacagcttta aacatacctg a                                               1401


<210>  81
<211>  1377
<212>  DNA
<213>  Sulfobacillus thermosulfidooxidans

<400>  81
atgaaaaaag catcggagga agtggcgatt aatcccttgt ttgcccgccg cggagaagaa       60

tcggttcccc gatatcgtct ctcggaagaa ggattattgc ctgaaacagc ctatcaaatt      120

gttcatgatg aattgacttt agacggcagt gctcggttaa acttggcgac ttttgtggga      180

acgtggatgg agccagaagc tcagaaactg tatgtcgaag cggccaataa aaatatcatc      240

gataaagatg aatatcctga gacggctgct attgaggaac ggtgtctgaa aatcctggca      300

aacttatgga atgctccgga tcccgccaat agtattgggg tgtccacaac aggttcatcg      360

gaagcttgca tgttaggagg cctggcttta aaaagacggt ggcaattatc ccggcgtcaa      420

caaggaaaat ccaccgacca tcccaatatt gtctttagtt cagctgtcca agtcgtctgg      480

gaaaagtttg cgaattattt tgaagtcgaa ccccgctatg tgaacatcac gcccgaacat      540

ccttatttga cgccagaagg tgtgatcaag gcggtggacg aaaatactat tggagttgtc      600

cccattttag gggtgaccta taccggcagt tacgaacccg ttgaagctat cgcacaggct      660

ttagatgatt tagaaaaacg cacgggcctg tccattccca ttcatgtgga tgcggcatcg      720

ggcggttttg tggcgccctt cttgcaacca gatttggtat gggattttag actgccgcgg      780

gtccattcta ttaatacctc aggccataaa tacggactgg tctatccggg gctgggatgg      840

gttttatggc gggataagac gttattgcca gaggaattaa tcttcaatgt ctcatattta      900

gggggcagta tgccaacgtt tggactcaat ttttccagac ccggggccca agttctcctt      960

caatactata attttcttcg gttgggacgt cagggctatt acacggtcca aaagacgtgt     1020

caaaatgttg ctcatttttt ggcacaggaa attggggcta tggagccgtt tgagctggta     1080

actgacggat cggatttgcc ggtatttgcc tggcgaaaaa gaccggaaga gaatccttta     1140

tggtctttag aggatttatc ttttgtattg cgggaacggg gatggcaagt accagcctat     1200

ccgttaccac caactatgca agacgttacc ataatgcgca ttgttgttcg caacagtttt     1260

tctatggata tggcacagct ctttttggat gacttaaacc gggcggtggc gtatttacag     1320

gggttagatc atccctttcc ccaggcttta cgccaacata aaccgtttgc tcattga        1377


<210>  82
<211>  1407
<212>  DNA
<213>  Lactobacillus brevis

<400>  82
atggctatgt tgtatggaaa acacacgcat gaaacagatg agacgctcac gccaatcttc       60

ggggccacag ctgaacgcca cgacctcccc aaatataaat tggcaaagca cgcgctcgag      120

ccccgtgaag ccgatcgatt ggttcgcgat caactattgg atgaaggaaa ctcgcggctg      180

aatctcgcca cgttctgtca gacttacatg gaaccggaag cggttgaact catgaaagat      240

acactggaga aaaacgccat cgataaatcc gagtatcctc ggaccgctga aattgaaaat      300

cgttgcgtta atatcattgc caacctctgg catgctccag aagctgagtc gttcactggc      360

acctcgacga ttggttcctc cgaggcctgc atgctggccg gtttggcgat gaagtttgct      420

tggcgtaagc gcgccaaagc gaacggtctt gacttaactg cccatcaacc taatattgtc      480

atctcagccg gttatcaagt ttgttgggaa aaattctgtg tctattggga catcgacatg      540

catgtcgttc ccatggacga tgaccacatg tccttgaatg tcgatcacgt gttagattac      600

gtggatgact acaccattgg tatcgttggc attatgggca tcacttatac tggacaatac      660

gacgatttag cccgattaga tgccgttgta gagcggtaca atcggacgac taagttcccg      720

gtatatatcc atgtcgatgc cgcttccggc ggattttaca cgccgtttat tgaacccgag      780

ctcaagtggg acttccgttt aaacaacgtg atttccatca atgcctccgg ccacaaatat      840

ggcttggttt atcccggagt cggctgggta atctggcgtg accaacagta tctaccaaaa      900

gagctggtct ttaaggtcag ctacttgggt ggtgaactac ctacgatggc catcaacttc      960

tcccacagtg cctcccaatt aatcggtcag tattacaact ttattcgctt tggttttgat     1020

ggctatcgtg aaattcaaga aaaaactcac gacgttgccc gctatctcgc gaaatcgctc     1080

actaaattag ggggcttttc cctcattaat gacggccacg agttaccgct gatctgttat     1140

gaactcactg ccgattctga tcgcgaatgg accctctacg atttatccga tcggttatta     1200

atgaagggct ggcaggttcc cacctatccc ttaccaaaaa acatgacgga ccgcgttatt     1260

caacggatcg tggttcgggc tgactttggt atgagtatgg cccacgactt tattgatgat     1320

ctaacccaag ccattcacga tctcgaccaa gcacacatcg ttttccatag tgatccgcaa     1380

cctaaaaaat acgggttcac gcactaa                                         1407


<210>  83
<211>  1401
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E. coli GAD mutant E89Q gene

<400>  83
atggataaga agcaagtaac ggatttaagg tcggaactac tcgattcacg ttttggtgcg       60

aagtctattt ccactatcgc agaatcaaaa cgttttccgc tgcacgaaat gcgcgacgat      120

gtcgcattcc agattatcaa tgacgaatta tatcttgatg gcaacgctcg tcagaacctg      180

gccactttct gccagacctg ggacgacgaa aatgtccaca aattgatgga tttatccatt      240

aacaaaaact ggatcgacaa agaacagtat ccgcaatccg cagccatcga cctgcgttgc      300

gtaaatatgg ttgccgatct gtggcatgcg cctgcgccga aaaatggtca ggccgttggc      360

accaacacca ttggttcttc cgaggcctgt atgctcggcg ggatggcgat gaaatggcgt      420

tggcgcaagc gtatggaagc tgcaggcaaa ccaacggata aaccaaacct ggtgtgcggt      480

ccggtacaaa tctgctggca taaattcgcc cgctactggg atgtggagct gcgtgagatc      540

cctatgcgcc ccggtcagtt gtttatggac ccgaaacgca tgattgaagc ctgtgacgaa      600

aacaccatcg gcgtggtgcc gactttcggc gtgacctaca ctggtaacta tgagttccca      660

caaccgctgc acgatgcgct ggataaattc caggccgata ccggtatcga catcgacatg      720

cacatcgacg ctgccagcgg tggcttcctg gcaccgttcg tcgccccgga tatcgtctgg      780

gacttccgcc tgccgcgtgt gaaatcgatc agtgcttcag gccataaatt cggtctggct      840

ccgctgggct gcggctgggt tatctggcgt gacgaagaag cgctgccgca ggaactggtg      900

ttcaacgttg actacctggg tggtcaaatt ggtacttttg ccatcaactt ctcccgcccg      960

gcgggtcagg taattgcaca gtactatgaa ttcctgcgcc tcggtcgtga aggctatacc     1020

aaagtacaga acgcctctta ccaggttgcc gcttatctgg cggatgaaat cgccaaactg     1080

gggccgtatg agttcatctg tacgggtcgc ccggacgaag gcatcccggc ggtttgcttc     1140

aaactgaaag atggtgaaga tccgggatac accctgtatg acctctctga acgtctgcgt     1200

ctgcgcggct ggcaggttcc ggccttcact ctcggcggtg aagccaccga catcgtggtg     1260

atgcgcatta tgtgtcgtcg cggcttcgaa atggactttg ctgaactgtt gctggaagac     1320

tacaaagcct ccctgaaata tctcagcgat cacccgaaac tgcagggtat tgcccaacag     1380

aacagcttta aacatacctg a                                               1401


<210>  84
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sth GAD mutant E84Q delta C14 gene

<400>  84
atgaaaaaag catcggagga agtggcgatt aatcccttgt ttgcccgccg cggagaagaa       60

tcggttcccc gatatcgtct ctcggaagaa ggattattgc ctgaaacagc ctatcaaatt      120

gttcatgatg aattgacttt agacggcagt gctcggttaa acttggcgac ttttgtggga      180

acgtggatgg agccagaagc tcagaaactg tatgtcgaag cggccaataa aaatatcatc      240

gataaagatc aatatcctga gacggctgct attgaggaac ggtgtctgaa aatcctggca      300

aacttatgga atgctccgga tcccgccaat agtattgggg tgtccacaac aggttcatcg      360

gaagcttgca tgttaggagg cctggcttta aaaagacggt ggcaattatc ccggcgtcaa      420

caaggaaaat ccaccgacca tcccaatatt gtctttagtt cagctgtcca agtcgtctgg      480

gaaaagtttg cgaattattt tgaagtcgaa ccccgctatg tgaacatcac gcccgaacat      540

ccttatttga cgccagaagg tgtgatcaag gcggtggacg aaaatactat tggagttgtc      600

cccattttag gggtgaccta taccggcagt tacgaacccg ttgaagctat cgcacaggct      660

ttagatgatt tagaaaaacg cacgggcctg tccattccca ttcatgtgga tgcggcatcg      720

ggcggttttg tggcgccctt cttgcaacca gatttggtat gggattttag actgccgcgg      780

gtccattcta ttaatacctc aggccataaa tacggactgg tctatccggg gctgggatgg      840

gttttatggc gggataagac gttattgcca gaggaattaa tcttcaatgt ctcatattta      900

gggggcagta tgccaacgtt tggactcaat ttttccagac ccggggccca agttctcctt      960

caatactata attttcttcg gttgggacgt cagggctatt acacggtcca aaagacgtgt     1020

caaaatgttg ctcatttttt ggcacaggaa attggggcta tggagccgtt tgagctggta     1080

actgacggat cggatttgcc ggtatttgcc tggcgaaaaa gaccggaaga gaatccttta     1140

tggtctttag aggatttatc ttttgtattg cgggaacggg gatggcaagt accagcctat     1200

ccgttaccac caactatgca agacgttacc ataatgcgca ttgttgttcg caacagtttt     1260

tctatggata tggcacagct ctttttggat gacttaaacc gggcggtggc gtatttacag     1320

gggttagatc attga                                                      1335


<210>  85
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lbr GAD 4AA mutant gene

<400>  85
atggccatgc tgtatggtaa gcacacccat gaaactgatg agaccctcat acccatattc       60

ggtgccactg ccgaacgtca cgacctccca aagtataagc tggcgaagca cgcgctcgag      120

ccacgtgaag ccgatcgtct ggtgcgtgat cagttgctgg atgaaggtaa ctcccgcttg      180

aatctcgcca ccttctgcca aacttacatg gaaccagaag cggtggaact catgaaggat      240

actttggaga agaacgccat agataagtcc gagtatccac gcaccgccga aatcgaaaat      300

cgttgtgtga atataatcgc caacctctgg catgcccccg aagccgagtc cttcactggt      360

acctccacca tcggctcctc cgaggcctgt atgttggccg gcctggcgat gaagtttgcc      420

tggcgtaagc gtgccaaggc gaacggcctc gacctgactg cccatcagcc aaatatcgtc      480

ataagcgccg gctatcaggt gtgctgggaa aagttctgcg tctattggga catagacatg      540

catgtcgtgc caatggacga tgaccacatg tccctgaatg tcgatcacgt gctggattac      600

gtggatgact acaccatcgg catagtgggt atcatgggta taacttatac tggtcagtac      660

gacgatctgg cccgtctgga tgccgtggta gagcgctaca atcgcaccac taagttccca      720

gtatatatac atgtcgatgc cgcctccggt ggtttttaca ccccatttat cgaaccagag      780

ctcaagtggg acttccgtct gaacaacgtg atctccataa atgcctccgg tcacaagtat      840

ggtctggtgt atccaggtgt cggttgggta atatggcgtg gtcagcaata tttgcccaag      900

gagttggtct ttaaggtctc ctacctgggc ggcagcttgc caaccatggc cataaacttc      960

tcccacagcg cctcccagct gataggccaa tattacaact ttatccgttt tggctttgat     1020

ggttatcgtg aaatccatga aaagactcac gacgtggccc gttatctcgc gaagtccctc     1080

actaagctgg gtggtttttc cctcatcaat gacggtcacg agctgccatt gatatgctat     1140

gaactcactg ccgattccga tcgtgaatgg accctctacg atctgtccga tcgcctgctg     1200

atgaagggtt ggcaagtgcc aacctatcca ctgcccaaga acatgaccga ccgtgtgatc     1260

cagcgcatag tggtgcgcgc cgactttggc atgagcatgg cccacgactt tatcgatgat     1320

ttgacccagg ccatccacga tctcgaccag gcgcacatag tgttccatag cgatccacag     1380

ccaaagaagt acggtttcac ccactaa                                         1407


<210>  86
<211>  1845
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Egr kdc (harmonized) gene

<400>  86
atgggcatcg ccctggatgg tcctgaccgc gaccgcatgt tcaacgccta cttgcattct       60

tcaaggccct cctttggacc ggccaccgat gtgttcgtgc agtgcttgga ggcagaaaag      120

atcgactgga tctttggaat ccccggggag gagaacttgg acctcctcca cagcctggca      180

aaggcgcacc gccgggaggg tggggagacg atgaagctcg tggtgacccg gcatgagcag      240

gcagctgggt ttatggcagc gactgtgggc cggctgacgg gacaccctgc ggcttgcctg      300

tcaaccctcg ggcctggagc caccaacttc accaccgctc tggcgtacag caagttgggc      360

ggtttccctt tgatctgtat cactgggcag aagcccatcc gtcacagcaa acagggtgcc      420

tttcagatcc tggacatctg cggtcacttc cgggatgtgg tgaagtccac aaagagcatc      480

gaggaccccg acctcatccc cagcacaatt cgcaatgccg tgctgcaggc gcgagaggag      540

aagcctggcc ccgtccacat tgaactggcc gaggacattg ccgccctgga ggtctccaag      600

gagggcggct gggtgttccc cgcccccacc cggacgccca tcgcccgcgg ccgtcgtccg      660

ctggtggagc ccaagtgcat tgagcacgcc gtgaccctta ttcatgccgc caagcgcccg      720

ctgatttgta tcgccgctgg agccaaccgc aagaacaccc accatgctat ggaggtgttg      780

atgcggaaga cggggctgat ggtggtgtgc acacagatgg gcaagggggt tgtgtacgag      840

gacaacctcg gatacatcgg ctgcacggcc ctgtcggaca aggacctggt gcacgtggcc      900

atcaacaccg cggacctcat cgtcaacgtg ggccacgaca tcagcgagaa gccgccgttc      960

atcatgaacc acaacaagcc ccccctggtc atccacgcca acttcacccg gcccctggtg     1020

gaccccgtgt acttcccaca cctcgtgctg gttggagaca tcaacgactg cctctggcag     1080

ctcgcgaccc gcatccggcc tcagccacac tgggacttca accccttcca gatggtccgc     1140

cgggagatcg agcgcaccgt gtggaacagc ccctacgccc agtccgatgc gttcccactg     1200

acggtccagc gcctcgtgtc ggacgtccgg aaggcgatgc cggtggatgg tatcgtcagc     1260

ctcgacaatg gcatgtacaa gatctggttt gcccggcagt acaagaccat gatgggcaac     1320

accctgctgt tggacaatgc gttggccacc atgggtgctg gactgccctc ttgcattgcg     1380

gccaagctag tgtaccctga gcgggtctgc atcgcagtgt gcggcgatgg cgggttcatg     1440

atgaacagcc aggagatcga gacagcattg aggctgaacc ttcacattgt ggtcatcgtg     1500

ctcaacaaca atagctatgg catgattgcc tggaaggcga ctgccatggg catggacgac     1560

ttcgggctga actacggcaa cccggacttc gcccagtacg cccgcgccta cggggccatc     1620

ggccacaacg tcaagtccac agccgagttc ctccccaccc tggagaaggc catcaaagag     1680

cacggcgtgc acatcatcga cctccccatc tcgtacgaga cgtcggacaa ggcccttttt     1740

gaggacctgc ccaaggaagt ggaggagctc aagaaggcgg tggccaaagc catctccgag     1800

gagaagaagt tcgactggga tgccgtgacg gcagctcaga gctag                     1845


<210>  87
<211>  1638
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ssc kdc (harmonized) gene

<400>  87
atgaacactg ctgaattgtt gattcggtgc ctcgaaaacg aaggcgtgga gtatatcttc       60

ggcttgccag gcgaagaaaa cctgcatatt ctggaagccc tcaaagagtc cccgattcgc      120

ttcattaccg tccgccatga acaaggcgcc gctttcatgg ccgacgtgta tggccgtttg      180

accggcaagg ctggcgtctg cttgtccacc ttgggcccag gcgctaccaa cctcatgact      240

ggcgtcgccg acgcaaatct ggacggcgca ccgttgatcg caatcactgg ccaagtgggc      300

accgatcgca tgcatatcga aagccatcag tatctcgact tggtggcaat gttcgccccg      360

gtcaccaaat ggaacaagca gatcgtccgg ccaaatacga ccccagaggt ggtacgtcgt      420

gccttcaaga tcgcccaaca agaaaagcca ggcgctgtac atattgacct gccagaaaac      480

atcgcagcaa tgccggtaga aggccaaccg ctgcaacgcg acggccgtga aaagatttat      540

gctagtagcc gcagcttgaa tcgcgctgcc gaggcaattg cccatgccaa aagcccattg      600

atcttggtgg gcaacggcat catccgcgcc gacgccgccg aagccctgac cgacttcgcc      660

acccaattga acatcccggt agtcaatacc ttcatgggca agggcgctat cccgtacacc      720

catccgttga gcttgtggac ggtaggtctg cagcaacgcg acttcgtcac ctgcgccttc      780

gaacaaagcg acttggtgat cgctgtgggc tacgacttga ttgaatatag cccgaagcgc      840

tggaatccag agggtacgac cccaatcatt catatcggcg aagtggccgc cgaaatcgac      900

agcagctata tcccgctgac tgaagtcgtc ggcgatatcg gcgacgcctt gaacgaaatc      960

cgtaagcgca ctgatcgtga gggcaagacc gcaccaaagt tcctgaacgt ccgcgctgag     1020

atccgcgagg attatgaacg ccatggcacc gatgctagct tcccagtcaa gccgcagaag     1080

attatttacg acctgcgcca ggtgatggcc ccagaggata ttgtcatctc cgacgtgggc     1140

gcccataaga tgtggatggc ccgccattac cattgtgacc gcccgaacac ttgtttgatc     1200

agcaacggtt tcgcagcaat gggcatcgca atcccgggcg ctgtagctgc caagttggtc     1260

tacccagaaa agaacgtcgt ggctgtcact ggcgatggcg gtttcatgat gaattgtcaa     1320

gagctggaaa cggccttgcg catcggcgca aatttcgtca ccctcatctt taacgacggc     1380

ggctatggct tgattggctg gaagcaaatc aatcaatttg gcgctccagc cttcgtggag     1440

ttcggcaacc cggacttcgt gcaattcgcc gaaagcatgg gcctgaaagg ctatcgcatc     1500

accgccgccg ccgatctcgt gccaaccttg aaggaagccc tcgcccaaga cgtaccagca     1560

gtgattgact gtccggtgga ttacagcgag aacgtgaagt ttagccagaa gagtggcgac     1620

ttgatttgtc gtatgtga                                                   1638


<210>  88
<211>  1281
<212>  DNA
<213>  Escherichia coli

<400>  88
atgaacagca ataaagagtt aatgcagcgc cgcagtcagg cgattccccg tggcgttggg       60

caaattcacc cgattttcgc tgaccgcgcg gaaaactgcc gggtgtggga cgttgaaggc      120

cgtgagtatc ttgatttcgc gggcgggatt gcggtgctca ataccgggca cctgcatccg      180

aaggtggtgg ccgcggtgga agcgcagttg aaaaaactgt cgcacacctg cttccaggtg      240

ctggcttacg agccgtatct ggagctgtgc gagattatga atcagaaggt gccgggcgat      300

ttcgccaaga aaacgctgct ggttacgacc ggttccgaag cggtggaaaa cgcggtaaaa      360

atcgcccgcg ccgccaccaa acgtagcggc accatcgctt ttagcggcgc gtatcacggg      420

cgcacgcatt acacgctggc gctgaccggc aaggtgaatc cgtactctgc gggcatgggg      480

ctgatgccgg gtcatgttta tcgcgcgctt tatccttgcc cgctgcacgg cataagcgag      540

gatgacgcta tcgccagcat ccaccggatc ttcaaaaatg atgccgcgcc ggaagatatc      600

gccgccatcg tgattgagcc ggttcagggc gaaggcggtt tctacgcctc gtcgccagcc      660

tttatgcagc gtttacgcgc tctgtgtgac gagcacggga tcatgctgat tgccgatgaa      720

gtgcagagcg gcgcggggcg taccggcacg ctgtttgcga tggagcagat gggcgttgcg      780

ccggatctta ccacctttgc gaaatcgatc gcgggcggct tcccgctggc gggcgtcacc      840

gggcgcgcgg aagtaatgga tgccgtcgct ccaggcggtc tgggcggcac ctatgcgggt      900

aacccgattg cctgcgtggc tgcgctggaa gtgttgaagg tgtttgagca ggaaaatctg      960

ctgcaaaaag ccaacgatct ggggcagaag ttgaaagacg gattgctggc gatagccgaa     1020

aaacacccgg agatcggcga cgtacgcggg ctgggggcga tgatcgccat tgagctgttt     1080

gaagacggcg atcacaacaa gccggacgcc aaactcaccg ccgagatcgt ggctcgcgcc     1140

cgcgataaag gcctgattct tctctcctgc ggcccgtatt acaacgtgct gcgcatcctt     1200

gtaccgctca ccattgaaga cgctcagatc cgtcagggtc tggagatcat cagccagtgt     1260

tttgatgagg cgaagcagta g                                               1281


<210>  89
<211>  1413
<212>  DNA
<213>  Streptomyces aizunensis

<400>  89
atgcgcccca tgaccgccaa aattttcgca gtcgattcgg tccgccctat cgatgagttt       60

gagcaagatg cattacgtgt agcagacgtc attcgtgaac gtggtgtatg ccttggtgat      120

cgtgtcatgt taaaagcagg taattcggcc tcgtatgtct gcgtcttata tgcacttatg      180

cacattggag ctagtattgt tttagttgat caacaagaac acaaagagga gactcgtcgt      240

attgcccttc gtacgggtgt taaagtcacg tttgtcgatg atgagacgcc tattgatcaa      300

gatgcagatc ccattcacct ttatgaatta atggtcgcga cgcaaaatcg cccaccaatg      360

gatagtgcgt tgtcttttga tgcatggggt gagctcagtg atggactcat tatgtggacg      420

agcggttcca cgggtagccc aaaaggtgtt gttaaatccg gtggcaaatt tctcgctaat      480

ttgcgtcgta atgcacacca agtaggacac cgtcctgatg atgttcttat gcccctttta      540

ccatttgcac accaatatgg gttgtcgatg gtcttgattg cgtggcttac acgttgttcc      600

cttgttattg cgccctatcg tcgtttagat cgtgcccttc gtatggcgcg tgattcgggt      660

acaaccgtta ttgatgccac tccttcgtca tatcgtagca ttttgggttt agtcacacgc      720

aaacccgcat tgcgtgccca cctcgctggt acacgtatgt tttgcgttgg agccgcgccc      780

ttggatgccc cacttgttga gtcgtatgtg caagagtttg gtttgccatt actcgatagc      840

tatggttcaa cagagctcaa taatattgcg tttgcaactc ttgataatcc cgtaagttgt      900

gggcgtgcga tggaaggtat tggcttacgt attgttgatg aggatgggcg tgaggttgcc      960

gctggccaac ccggtgagat tgaggtagat acgcccgatg cgttggaagg gcaaatcgca     1020

gaggatggct cgattattcc cgcccctacg ggttggcaac gtaccgggga tctcggtcac     1080

ttggatgccg atggaaattt atatgtactc ggacgtaaat ttgcggtaca ccgtatgggg     1140

tatacattat accctgagtt gattgagcgt aaagtcgcgg ctgaggggtg tcctacgcgt     1200

attgtacctt tacccgatga attgcgtggt tcgcaacttg ttttctttgt cgaggatgat     1260

gagcaacgtg atgcggggta ttggcgtgag cgtctttgtg gattattgcc agcatttgag     1320

caacctaata aagtagttgt cttggagcaa tttcccctta atcgtaatgg aaaacccgat     1380

aagaaagagt taactcgtat ggcggcagaa taa                                  1413


<210>  90
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E. coli GAD mutant E89Q delta C14

<400>  90

Met Asp Lys Lys Gln Val Thr Asp Leu Arg Ser Glu Leu Leu Asp Ser 
1               5                   10                  15      


Arg Phe Gly Ala Lys Ser Ile Ser Thr Ile Ala Glu Ser Lys Arg Phe 
            20                  25                  30          


Pro Leu His Glu Met Arg Asp Asp Val Ala Phe Gln Ile Ile Asn Asp 
        35                  40                  45              


Glu Leu Tyr Leu Asp Gly Asn Ala Arg Gln Asn Leu Ala Thr Phe Cys 
    50                  55                  60                  


Gln Thr Trp Asp Asp Glu Asn Val His Lys Leu Met Asp Leu Ser Ile 
65                  70                  75                  80  


Asn Lys Asn Trp Ile Asp Lys Glu Gln Tyr Pro Gln Ser Ala Ala Ile 
                85                  90                  95      


Asp Leu Arg Cys Val Asn Met Val Ala Asp Leu Trp His Ala Pro Ala 
            100                 105                 110         


Pro Lys Asn Gly Gln Ala Val Gly Thr Asn Thr Ile Gly Ser Ser Glu 
        115                 120                 125             


Ala Cys Met Leu Gly Gly Met Ala Met Lys Trp Arg Trp Arg Lys Arg 
    130                 135                 140                 


Met Glu Ala Ala Gly Lys Pro Thr Asp Lys Pro Asn Leu Val Cys Gly 
145                 150                 155                 160 


Pro Val Gln Ile Cys Trp His Lys Phe Ala Arg Tyr Trp Asp Val Glu 
                165                 170                 175     


Leu Arg Glu Ile Pro Met Arg Pro Gly Gln Leu Phe Met Asp Pro Lys 
            180                 185                 190         


Arg Met Ile Glu Ala Cys Asp Glu Asn Thr Ile Gly Val Val Pro Thr 
        195                 200                 205             


Phe Gly Val Thr Tyr Thr Gly Asn Tyr Glu Phe Pro Gln Pro Leu His 
    210                 215                 220                 


Asp Ala Leu Asp Lys Phe Gln Ala Asp Thr Gly Ile Asp Ile Asp Met 
225                 230                 235                 240 


His Ile Asp Ala Ala Ser Gly Gly Phe Leu Ala Pro Phe Val Ala Pro 
                245                 250                 255     


Asp Ile Val Trp Asp Phe Arg Leu Pro Arg Val Lys Ser Ile Ser Ala 
            260                 265                 270         


Ser Gly His Lys Phe Gly Leu Ala Pro Leu Gly Cys Gly Trp Val Ile 
        275                 280                 285             


Trp Arg Asp Glu Glu Ala Leu Pro Gln Glu Leu Val Phe Asn Val Asp 
    290                 295                 300                 


Tyr Leu Gly Gly Gln Ile Gly Thr Phe Ala Ile Asn Phe Ser Arg Pro 
305                 310                 315                 320 


Ala Gly Gln Val Ile Ala Gln Tyr Tyr Glu Phe Leu Arg Leu Gly Arg 
                325                 330                 335     


Glu Gly Tyr Thr Lys Val Gln Asn Ala Ser Tyr Gln Val Ala Ala Tyr 
            340                 345                 350         


Leu Ala Asp Glu Ile Ala Lys Leu Gly Pro Tyr Glu Phe Ile Cys Thr 
        355                 360                 365             


Gly Arg Pro Asp Glu Gly Ile Pro Ala Val Cys Phe Lys Leu Lys Asp 
    370                 375                 380                 


Gly Glu Asp Pro Gly Tyr Thr Leu Tyr Asp Leu Ser Glu Arg Leu Arg 
385                 390                 395                 400 


Leu Arg Gly Trp Gln Val Pro Ala Phe Thr Leu Gly Gly Glu Ala Thr 
                405                 410                 415     


Asp Ile Val Val Met Arg Ile Met Cys Arg Arg Gly Phe Glu Met Asp 
            420                 425                 430         


Phe Ala Glu Leu Leu Leu Glu Asp Tyr Lys Ala Ser Leu Lys Tyr Leu 
        435                 440                 445             


Ser Asp His Pro 
    450         


<210>  91
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E. coli GAD mutant E89Q delta C14 gene

<400>  91
atggataaga agcaagtaac ggatttaagg tcggaactac tcgattcacg ttttggtgcg       60

aagtctattt ccactatcgc agaatcaaaa cgttttccgc tgcacgaaat gcgcgacgat      120

gtcgcattcc agattatcaa tgacgaatta tatcttgatg gcaacgctcg tcagaacctg      180

gccactttct gccagacctg ggacgacgaa aatgtccaca aattgatgga tttatccatt      240

aacaaaaact ggatcgacaa agaacagtat ccgcaatccg cagccatcga cctgcgttgc      300

gtaaatatgg ttgccgatct gtggcatgcg cctgcgccga aaaatggtca ggccgttggc      360

accaacacca ttggttcttc cgaggcctgt atgctcggcg ggatggcgat gaaatggcgt      420

tggcgcaagc gtatggaagc tgcaggcaaa ccaacggata aaccaaacct ggtgtgcggt      480

ccggtacaaa tctgctggca taaattcgcc cgctactggg atgtggagct gcgtgagatc      540

cctatgcgcc ccggtcagtt gtttatggac ccgaaacgca tgattgaagc ctgtgacgaa      600

aacaccatcg gcgtggtgcc gactttcggc gtgacctaca ctggtaacta tgagttccca      660

caaccgctgc acgatgcgct ggataaattc caggccgata ccggtatcga catcgacatg      720

cacatcgacg ctgccagcgg tggcttcctg gcaccgttcg tcgccccgga tatcgtctgg      780

gacttccgcc tgccgcgtgt gaaatcgatc agtgcttcag gccataaatt cggtctggct      840

ccgctgggct gcggctgggt tatctggcgt gacgaagaag cgctgccgca ggaactggtg      900

ttcaacgttg actacctggg tggtcaaatt ggtacttttg ccatcaactt ctcccgcccg      960

gcgggtcagg taattgcaca gtactatgaa ttcctgcgcc tcggtcgtga aggctatacc     1020

aaagtacaga acgcctctta ccaggttgcc gcttatctgg cggatgaaat cgccaaactg     1080

gggccgtatg agttcatctg tacgggtcgc ccggacgaag gcatcccggc ggtttgcttc     1140

aaactgaaag atggtgaaga tccgggatac accctgtatg acctctctga acgtctgcgt     1200

ctgcgcggct ggcaggttcc ggccttcact ctcggcggtg aagccaccga catcgtggtg     1260

atgcgcatta tgtgtcgtcg cggcttcgaa atggactttg ctgaactgtt gctggaagac     1320

tacaaagcct ccctgaaata tctcagcgat cacccgtga                            1359


<210>  92
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S. thermosulfidooxidans GAD mutant E84Q delta C14

<400>  92

Met Lys Lys Ala Ser Glu Glu Val Ala Ile Asn Pro Leu Phe Ala Arg 
1               5                   10                  15      


Arg Gly Glu Glu Ser Val Pro Arg Tyr Arg Leu Ser Glu Glu Gly Leu 
            20                  25                  30          


Leu Pro Glu Thr Ala Tyr Gln Ile Val His Asp Glu Leu Thr Leu Asp 
        35                  40                  45              


Gly Ser Ala Arg Leu Asn Leu Ala Thr Phe Val Gly Thr Trp Met Glu 
    50                  55                  60                  


Pro Glu Ala Gln Lys Leu Tyr Val Glu Ala Ala Asn Lys Asn Ile Ile 
65                  70                  75                  80  


Asp Lys Asp Gln Tyr Pro Glu Thr Ala Ala Ile Glu Glu Arg Cys Leu 
                85                  90                  95      


Lys Ile Leu Ala Asn Leu Trp Asn Ala Pro Asp Pro Ala Asn Ser Ile 
            100                 105                 110         


Gly Val Ser Thr Thr Gly Ser Ser Glu Ala Cys Met Leu Gly Gly Leu 
        115                 120                 125             


Ala Leu Lys Arg Arg Trp Gln Leu Ser Arg Arg Gln Gln Gly Lys Ser 
    130                 135                 140                 


Thr Asp His Pro Asn Ile Val Phe Ser Ser Ala Val Gln Val Val Trp 
145                 150                 155                 160 


Glu Lys Phe Ala Asn Tyr Phe Glu Val Glu Pro Arg Tyr Val Asn Ile 
                165                 170                 175     


Thr Pro Glu His Pro Tyr Leu Thr Pro Glu Gly Val Ile Lys Ala Val 
            180                 185                 190         


Asp Glu Asn Thr Ile Gly Val Val Pro Ile Leu Gly Val Thr Tyr Thr 
        195                 200                 205             


Gly Ser Tyr Glu Pro Val Glu Ala Ile Ala Gln Ala Leu Asp Asp Leu 
    210                 215                 220                 


Glu Lys Arg Thr Gly Leu Ser Ile Pro Ile Val Asp Ala Ala Ser Gly 
225                 230                 235                 240 


Gly Phe Val Ala Pro Phe Leu Gln Pro Asp Leu Val Trp Asp Phe Arg 
                245                 250                 255     


Leu Pro Arg Val His Ser Ile Asn Thr Ser Gly His Lys Tyr Gly Leu 
            260                 265                 270         


Val Tyr Pro Gly Leu Gly Trp Val Leu Trp Arg Asp Lys Thr Leu Leu 
        275                 280                 285             


Pro Glu Glu Leu Ile Phe Asn Val Ser Tyr Leu Gly Gly Ser Met Pro 
    290                 295                 300                 


Thr Phe Gly Leu Asn Phe Ser Arg Pro Gly Ala Gln Val Leu Leu Gln 
305                 310                 315                 320 


Tyr Tyr Asn Phe Leu Arg Leu Gly Arg Gln Gly Tyr Tyr Thr Val Gln 
                325                 330                 335     


Lys Thr Cys Gln Asn Val Ala His Phe Leu Ala Gln Glu Ile Gly Ala 
            340                 345                 350         


Met Glu Pro Phe Glu Leu Val Thr Asp Gly Ser Asp Leu Pro Val Phe 
        355                 360                 365             


Ala Trp Arg Lys Arg Pro Glu Glu Asn Pro Leu Trp Ser Leu Glu Asp 
    370                 375                 380                 


Leu Ser Phe Val Leu Arg Glu Arg Gly Trp Gln Val Pro Ala Tyr Pro 
385                 390                 395                 400 


Leu Pro Pro Thr Met Gln Asp Val Thr Ile Met Arg Ile Val Val Arg 
                405                 410                 415     


Asn Ser Phe Ser Met Asp Met Ala Gln Leu Phe Leu Asp Asp Leu Asn 
            420                 425                 430         


Arg Ala Val Ala Tyr Leu Gln Gly Leu Asp His 
        435                 440             


