                         SEQUENCE LISTING

<110>  GENETHON
       UNIVERSITE D'EVRY VAL D'ESSONNE
       INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
 
<120>  ENHANCING UTROPHIN EXPRESSION IN CELL BY INDUCING MUTATIONS 
       WITHIN UTROPHIN REGULATORY ELEMENTS AND THERAPEUTIC USE THEREOF

<130>  B2006167EPWO

<160>  43    

<170>  PatentIn version 3.5

<210>  1
<211>  24
<212>  DNA
<213>  homo sapiens

<400>  1
agccatgacc acctttctac ctca                                              24


<210>  2
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  2
tcatacccaa gaaagcacct                                                   20


<210>  3
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  gRNA targeting miR-Let7c binding site

<400>  3
ctgaggtaga aaggtgatca                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  gRNA targeting miR-Let7c binding site

<400>  4
ctgaggtaga aaggtggtca                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  gRNA targeting miR-Let7c binding site

<400>  5
atggatctga ggtagaaagg                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  gRNA targeting miR-Let7c-binding site

<400>  6
aagatggatc tgaggtagaa                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  gRNA targeting miR-196-b binding site

<400>  7
gtgctttctt gggtatgaca                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  gRNA targeting miR-196-b binding site

<400>  8
ctttaaatag gtgctttctt                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  gRNA targeting ERF binding site

<400>  9
tcttccggaa caaagttgct                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  gRNA targeting ERF binding site

<400>  10
gaacaaagtt gctgggccgg                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  gRNA targeting ERF binding site

<400>  11
acgtagtggg gctgatcttc                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  gRNA targeting ERF binding site

<400>  12
ccggcccagc aactttgttc                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  gRNA targeting ERF binding site

<400>  13
atcttccgga acaaagttgc                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  gRNA targeting ERF binding site

<400>  14
tcttccggaa caaagttgct                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  gRNA targeting EN1 binding site 2

<400>  15
atcagcccca ctacgttccc                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  gRNA targeting EN1 binding site 2

<400>  16
gctgacccgg gaacgtagtg                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  gRNA targeting EN1 binding site 2

<400>  17
acgctgaccc gggaacgtag                                                   20


<210>  18
<211>  52
<212>  DNA
<213>  homo sapiens

<400>  18
ttatataaaa aggaaagcca tgaccacctt tctacctcag atccatcttc at               52


<210>  19
<211>  50
<212>  DNA
<213>  homo sapiens

<400>  19
ttttatcagg ccatgtcata cccaagaaag cacctattta aagaaaaaac                  50


<210>  20
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  20
agtggggctg atcttccgga acaaagttgc tgggcc                                 36


<210>  21
<211>  37
<212>  DNA
<213>  Homo sapiens

<400>  21
cgctgacccg ggaacgtagt ggggctgatc ttccgga                                37


<210>  22
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer 5' of Utrophin A

<400>  22
acgaattcag tgacatcatt aagtcc                                            26


<210>  23
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer 5' of utrophin A

<400>  23
atccatttgg taaaggtttt cttctg                                            26


<210>  24
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  gRNA targeting miR-150-133b-296-5p(II) binding site

<400>  24
ttattttaga ataggttggg                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  gRNA targeting miR-Let7c-binding site

<400>  25
aaggtggttc tgaggtagaa                                                   20


<210>  26
<211>  54
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide

<400>  26
ttatataaaa aggaaagcca tgaccacctt tctacctcag atccatcttc atcc             54


<210>  27
<211>  20
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide (gRNA)

<400>  27
cugagguaga aaggugauca                                                   20


<210>  28
<211>  20
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide (gRNA)

<400>  28
cugagguaga aaggugguca                                                   20


<210>  29
<211>  20
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide (gRNA)

<400>  29
auggaucuga gguagaaagg                                                   20


<210>  30
<211>  20
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide (gRNA)

<400>  30
aagauggauc ugagguagaa                                                   20


<210>  31
<211>  20
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide (gRNA)

<400>  31
aaggugguuc ugagguagaa                                                   20


<210>  32
<211>  20
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide (gRNA)

<400>  32
gugcuuucuu ggguaugaca                                                   20


<210>  33
<211>  20
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide (gRNA)

<400>  33
cuuuaaauag gugcuuucuu                                                   20


<210>  34
<211>  20
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide (gRNA)

<400>  34
ucuuccggaa caaaguugcu                                                   20


<210>  35
<211>  20
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide (gRNA)

<400>  35
gaacaaaguu gcugggccgg                                                   20


<210>  36
<211>  20
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide (gRNA)

<400>  36
acguaguggg gcugaucuuc                                                   20


<210>  37
<211>  20
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide (gRNA)

<400>  37
ccggcccagc aacuuuguuc                                                   20


<210>  38
<211>  20
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide (gRNA)

<400>  38
aucuuccgga acaaaguugc                                                   20


<210>  39
<211>  20
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide (gRNA)

<400>  39
ucuuccggaa caaaguugcu                                                   20


<210>  40
<211>  20
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide (gRNA)

<400>  40
aucagcccca cuacguuccc                                                   20


<210>  41
<211>  20
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide (gRNA)

<400>  41
gcugacccgg gaacguagug                                                   20


<210>  42
<211>  20
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide (gRNA)

<400>  42
acgcugaccc gggaacguag                                                   20


<210>  43
<211>  2046
<212>  DNA
<213>  Homo sapiens

<400>  43
gcaatgtgaa gtattcatcc ggccaaccaa tgtttcctga cgtacagtgt tgcccttttc       60

agcaaatgcc aattccaagt tccattaaat cagaagctcc atggctcctt ggcccacgat      120

gttgagtgct gactgtgtgt tctactgaaa gagtaaaaca ctgactatcc aaagagaaat      180

ggatattttg tttttataat aaccatatat tattgttttc ttcttccctt tctatgcaag      240

tgtaaattaa tgaacagaga ggtatttgga aatggtaata catttgtcac ggatttgtat      300

aatgtataca gcattgggaa agtgggtggg ggctttctaa tatgataccg tctttttaat      360

aactatgaca aagcttacat aagaattaga agaccacttt acatttttac attccttctg      420

ctgttcatat taaccttgca caattacttc attttttctt tgactctttt accacaatgt      480

tttggttatt tataatttat cagccatatg tttatcagcc atataaccaa ctagatccca      540

aatagatcca tgtatttgtt tccgtgattt ggccacatta ataaattcat aaatttcaat      600

caaatatctt atatatacac acatatggtt taagctacag ccctgtgtat gccgtttaac      660

tttatttgac gttgcccact tacttctttg ctgaccactt ggataaccgt aataaaaatc      720

ctataagcct aaatggcatt tcttttggga tatttttcct gcattttatt ccctttttat      780

ataagtagga attaattatt tattttatgt cttaatctat ttgataaaga agactacatt      840

ataataatct caaagatcat attaccaaag gttgcccact tgagcatatt ttcattttga      900

cacagaaaca aaatttagta caacctttcc tagttcccat gtcttgattt tcatcattac      960

atgcacagca gacctttacc tattgtgata ccagaacaca tcattgtctt tggttccctt     1020

caaagagaat tttattgttg ttttgtattt tcaagtcctt aatagttctt gaaactccta     1080

gttgttttct tgttgaaagc agacacacat ttagtgcacg gcttatttta cctttcgggt     1140

gaaagatcag atgtttttat acccttcact tgatcaatat atttggaaag aatgtttatc     1200

aaaagtctat gtcactgctt ctacagaaga atgaaattaa tgcttaggtg atggtacctc     1260

cacctacatc tttttgagtg cattcaatta tgtattttgg tttagcttct gatttaacat     1320

ttaattgatt cagtttaaac atgttactta attagcaaat gtagaggaac caaaaaaagg     1380

tgaaaataat atgttttgat tcaaacctaa agacataaaa acataaagac attttaactt     1440

tgggttctct ttagctggga tctggccaga aggaggctta aagttagaaa ttgctattat     1500

tttagaatag gttgggtggg ttggggggca agggtgtcta tttgcagcag agatattttg     1560

aaaagaagaa aattgtttta tataaaaagg aaagccatga ccacctttct acctcagatc     1620

catcttcatc cattgcattg gaaactgctt tatgctgctg cagtctgcaa agtctagagc     1680

ttttatcagg ccatgtcata cccaagaaag cacctattta aagaaaaaac aattccctga     1740

gctctcaact ccaagttgta gatttggtgt cttccttgtt cttactttaa aaagtcatgt     1800

gttaattttt tttctgcctg tatttgtatg caaaatgtcc tctatctgct attaaagaaa     1860

agctacgtaa aacactacat tgtaaccttc taagtaataa taaataaaaa gaaatatatt     1920

gcagtaacaa tgggaagtaa gtatgtagtt cttttgaaat atgtggtaaa gaactaatca     1980

cagactatca tctaatctgg ttacatattg tatttttcat cctgaataaa agtaatttta     2040

acacaa                                                                2046


