                         SEQUENCE LISTING

<110>  CRM Therapeutics B.V.
 
<120>  Target mediated endocytotic drug delivery

<130>  100537PC

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  750
<212>  DNA 
<213>  plasmid
<221>  amytin

<400>  1
MetGlyLysSerGluSerGlnMetAspIle ThrAspIleAsnThrProLysProLysLys LysGlnArgTrpThrProLeuGluIleSer LeuSerValLeuValLeuLeuLeuThrIle IleAlaValThrMetIleAlaLeuTyrAla ThrTyrAspAspGlyIleCysLysSerSer 60
AspCysIleLysSerAlaAlaArgLeuIle GlnAsnMetAspAlaThrThrGluProCys ThrAspPhePheLysTyrAlaCysGlyGly TrpLeuLysArgAsnValIleProGluThr SerSerArgTyrGlyAsnPheAspIleLeu ArgAspGluLeuGluValValLeuLysAsp 120
ValLeuGlnGluProLysThrGluAspIle ValAlaValGlnLysAlaLysAlaLeuTyr ArgSerCysIleAsnGluSerAlaIleAsp SerArgGlyGlyGluProLeuLeuLysLeu LeuProAspIleTyrGlyTrpProValAla ThrGluAsnTrpGluGlnLysTyrGlyAla 180
SerTrpThrAlaGluLysAlaIleAlaGln LeuAsnSerLysTyrGlyLysLysValLeu IleAsnLeuPheValGlyThrAspAspLys AsnSerValAsnHisValIleHisIleAsp GlnProArgLeuGlyLeuProSerArgAsp TyrTyrGluCysThrGlyIleTyrLysGlu 240
AlaCysThrAlaTyrValAspPheMetIle SerValAlaArgLeuIleArgGlnGluGlu ArgLeuProIleAspGluAsnGlnLeuAla LeuGluMetAsnLysValMetGluLeuGlu LysGluIleAlaAsnAlaThrAlaLysPro GluAspArgAsnAspProMetLeuLeuTyr 300
AsnLysMetThrLeuAlaGlnIleGlnAsn AsnPheSerLeuGluIleAsnGlyLysPro PheSerTrpLeuAsnPheThrAsnGluIle MetSerThrValAsnIleSerIleThrAsn GluGluAspValValValTyrAlaProGlu TyrLeuThrLysLeuLysProIleLeuThr 360
LysTyrSerAlaArgAspLeuGlnAsnLeu MetSerTrpArgPheIleMetAspLeuVal SerSerLeuSerArgThrTyrLysGluSer ArgAsnAlaPheArgLysAlaLeuTyrGly ThrThrSerGluThrAlaThrTrpArgArg CysAlaAsnTyrValAsnGlyAsnMetGlu 420
AsnAlaValGlyArgLeuTyrValGluAla AlaPheAlaGlyGluSerLysHisValVal GluAspLeuIleAlaGlnIleArgGluVal PheIleGlnThrLeuAspAspLeuThrTrp MetAspAlaGluThrLysLysArgAlaGlu GluLysAlaLeuAlaIleLysGluArgIle 480
GlyTyrProAspAspIleValSerAsnAsp AsnLysLeuAsnAsnGluTyrLeuGluLeu AsnTyrLysGluAspGluTyrPheGluAsn IleIleGlnAsnLeuLysPheSerGlnSer LysGlnLeuLysLysLeuArgGluLysVal AspLysAspGluTrpIleSerGlyAlaAla 540
ValValAsnAlaPheTyrSerSerGlyArg AsnGlnIleValPheProAlaGlyIleLeu GlnProProPhePheSerAlaGlnGlnSer AsnSerLeuAsnTyrGlyGlyIleGlyMet ValIleGlyHisGluIleThrHisGlyPhe AspAspAsnGlyArgAsnPheAsnLysAsp 600
GlyAspLeuValAspTrpTrpThrGlnGln SerAlaSerAsnPheLysGluGlnSerGln CysMetValTyrGlnTyrGlyAsnPheSer TrpAspLeuAlaGlyGlyGlnHisLeuAsn GlyIleAsnThrLeuGlyGluAsnIleAla AspAsnGlyGlyLeuGlyGlnAlaTyrArg 660
AlaTyrGlnAsnTyrIleLysLysAsnGly GluGluLysLeuLeuProGlyLeuAspLeu AsnHisLysGlnLeuPhePheLeuAsnPhe AlaGlnValTrpCysGlyThrTyrArgPro GluTyrAlaValAsnSerIleLysThrAsp ValHisSerProGlyAsnPheArgIleIle 720
GlyThrLeuGlnAsnSerAlaGluPheSer GluAlaPheHisCysArgLysAsnSerTyr MetAsnProGluLysLysCysArgValTrp				  								  750


<210>  2
<211>  121
<212>  DNA
<213>  plasmid
<221>  Apoptin

<400>  2
MetAsnAlaLeuGlnGluAspThrProPro GlyProSerThrValPheArgProProThr SerSerArgProLeuGluThrProHisCys ArgGluIleArgIleGlyIleAlaGlyIle ThrIleThrLeuSerLeuCysGlyCysAla AsnAlaArgAlaProThrLeuArgSerAla  60
ThrAlaAspAsnSerGluSerThrGlyPhe LysAsnValProAspLeuArgThrAspGln ProLysProProSerLysLysArgSerCys AspProSerGluTyrArgValSerGluLeu LysGluSerLeuIleThrThrThrProSer ArgProArgThrAlaLysArgArgIleArg 120
Leu  								  															  121



<210>  3
<211>  42
<212>  DNA 
<213>  plasmid
<221>  glatimar-acetate

<400>  3
GluAlaTyrLysAlaAlaGluLysAlaTyr AlaAlaLysGluAlaAlaLysAlaLysAla GluLysLysAlaAlaTyrAlaLysAlaLys AlaAlaLysTyrGluLysLysAlaLysLys AlaAla							 42  

<210>  4
<211>  1154
<212>  DNA 
<213>  plasmid

<400>  4
MetGlnTyrLeuAsnIleLysGluAspCys AsnAlaMetAlaPheCysAlaLysMetArg SerSerLysLysThrGluValAsnLeuGlu AlaProGluProGlyValGluValIlePhe TyrLeuSerAspArgGluProLeuArgLeu GlySerGlyGluTyrThrAlaGluGluLeu   60
CysIleArgAlaAlaGlnAlaCysArgIle SerProLeuCysHisAsnLeuPheAlaLeu TyrAspGluAsnThrLysLeuTrpTyrAla ProAsnArgThrIleThrValAspAspLys MetSerLeuArgLeuHisTyrArgMetArg PheTyrPheThrAsnTrpHisGlyThrAsn  120
AspAsnGluGlnSerValTrpArgHisSer ProLysLysGlnLysAsnGlyTyrGluLys LysLysIleProAspAlaThrProLeuLeu AspAlaSerSerLeuGluTyrLeuPheAla GlnGlyGlnTyrAspLeuValLysCysLeu AlaProIleArgAspProLysThrGluGln  180
AspGlyHisAspIleGluAsnGluCysLeu GlyMetAlaValLeuAlaIleSerHisTyr AlaMetMetLysLysMetGlnLeuProGlu LeuProLysAspIleSerTyrLysArgTyr IleProGluThrLeuAsnLysSerIleArg GlnArgAsnLeuLeuThrArgMetArgIle  240
AsnAsnValPheLysAspPheLeuLysGlu PheAsnAsnLysThrIleCysAspSerSer ValSerThrHisAspLeuLysValLysTyr LeuAlaThrLeuGluThrLeuThrLysHis TyrGlyAlaGluIlePheGluThrSerMet LeuLeuIleSerSerGluAsnGluMetAsn  300
TrpPheHisSerAsnAspGlyGlyAsnVal LeuTyrTyrGluValMetValThrGlyAsn LeuGlyIleGlnTrpArgHisLysProAsn ValValSerValGluLysGluLysAsnLys LeuLysArgLysLysLeuGluAsnLysHis LysLysAspGluGluLysAsnLysIleArg  360
GluGluTrpAsnAsnPheSerTyrPhePro GluIleThrHisIleValIleLysGluSer ValValSerIleAsnLysGlnAspAsnLys LysMetGluLeuLysLeuSerSerHisGlu GluAlaLeuSerPheValSerLeuValAsp GlyTyrPheArgLeuThrAlaAspAlaHis  420
HisTyrLeuCysThrAspValAlaProPro LeuIleValHisAsnIleGlnAsnGlyCys HisGlyProIleCysThrGluTyrAlaIle AsnLysLeuArgGlnGluGlySerGluGlu GlyMetTyrValLeuArgTrpSerCysThr AspPheAspAsnIleLeuMetThrValThr  480
CysPheGluLysSerGluGlnValGlnGly AlaGlnLysGlnPheLysAsnPheGlnIle GluValGlnLysGlyArgTyrSerLeuHis GlySerAspArgSerPheProSerLeuGly AspLeuMetSerHisLeuLysLysGlnIle LeuArgThrAspAsnIleSerPheMetLeu  540
LysArgCysCysGlnProLysProArgGlu IleSerAsnLeuLeuValAlaThrLysLys AlaGlnGluTrpGlnProValTyrProMet SerGlnLeuSerPheAspArgIleLeuLys LysAspLeuValGlnGlyGluHisLeuGly ArgGlyThrArgThrHisIleTyrSerGly  600
ThrLeuMetAspTyrLysAspAspGluGly ThrSerGluGluLysLysIleLysValIle LeuLysValLeuAspProSerHisArgAsp IleSerLeuAlaPhePheGluAlaAlaSer MetMetArgGlnValSerHisLysHisIle ValTyrLeuTyrGlyValCysValArgAsp  660
ValGluAsnIleMetValGluGluPheVal GluGlyGlyProLeuAspLeuPheMetHis ArgLysSerAspValLeuThrThrProTrp LysPheLysValAlaLysGlnLeuAlaSer AlaLeuSerTyrLeuGluAspLysAspLeu ValHisGlyAsnValCysThrLysAsnLeu  720
LeuLeuAlaArgGluGlyIleAspSerGlu CysGlyProPheIleLysLeuSerAspPro GlyIleProIleThrValLeuSerArgGln GluCysIleGluArgIleProTrpIleAla ProGluCysValGluAspSerLysAsnLeu SerValAlaAlaAspLysTrpSerPheGly  780
ThrThrLeuTrpGluIleCysTyrAsnGly GluIleProLeuLysAspLysThrLeuIle GluLysGluArgPheTyrGluSerArgCys ArgProValThrProSerCysLysGluLeu AlaAspLeuMetThrArgCysMetAsnTyr AspProAsnGlnArgProPhePheArgAla  840
IleMetArgAspIleAsnLysLeuGluGlu GlnAsnProAspIleValSerGluLysLys ProAlaThrGluValAspProThrHisPhe GluLysArgPheLeuLysArgIleArgAsp LeuGlyGluGlyHisPheGlyLysValGlu LeuCysArgTyrAspProGluGlyAspAsn  900
ThrGlyGluGlnValAlaValLysSerLeu LysProGluSerGlyGlyAsnHisIleAla AspLeuLysLysGluIleGluIleLeuArg AsnLeuTyrHisGluAsnIleValLysTyr LysGlyIleCysThrGluAspGlyGlyAsn GlyIleLysLeuIleMetGluPheLeuPro  960
SerGlySerLeuLysGluTyrLeuProLys AsnLysAsnLysIleAsnLeuLysGlnGln LeuLysTyrAlaValGlnIleCysLysGly MetAspTyrLeuGlySerArgGlnTyrVal HisArgAspLeuAlaAlaArgAsnValLeu ValGluSerGluHisGlnValLysIleGly 1030
AspPheGlyLeuThrLysAlaIleGluThr AspLysGluTyrTyrThrValLysAspAsp ArgAspSerProValPheTrpTyrAlaPro GluCysLeuMetGlnSerLysPheTyrIle AlaSerAspValTrpSerPheGlyValThr LeuHisGluLeuLeuThrTyrCysAspSer 1080
AspSerSerProMetAlaLeuPheLeuLys MetIleGlyProThrHisGlyGlnMetThr ValThrArgLeuValAsnThrLeuLysGlu GlyLysArgLeuProCysProProAsnCys ProAspGluValTyrGlnLeuMetArgLys CysTrpGluPheGlnProSerAsnArgThr 1140
SerPheGlnAsnLeuIleGluGlyPheGlu AlaLeuLeuLys																		  1154

<210>  5
<211>  2281
<212>  mRNA
<213>  mRNA

<400>  5
	 					  	
ggaattactt gcagggctaa cctagtgcct atagctaagg caggtacctg catccttgtt   60
tttgtttagt ggatcctcta tccttcagag actctggaac ccctgtggtc ttctcttcat  120
ctaatgaccc tgaggggatg gagttttcaa gtccttccag agaggaatgt cccaagcctt  180
tgagtagggt aagcatcatg gctggcagcc tcacaggatt gcttctactt caggcagtgt  240
cgtgggcatc aggtgcccgc ccctgcatcc ctaaaagctt cggctacagc tcggtggtgt  300
gtgtctgcaa tgccacatac tgtgactcct ttgacccccc gacctttcct gcccttggta  360
ccttcagccg ctatgagagt acacgcagtg ggcgacggat ggagctgagt atggggccca  420
tccaggctaa tcacacgggc acaggcctgc tactgaccct gcagccagaa cagaagttcc  480
agaaagtgaa gggatttgga ggggccatga cagatgctgc tgctctcaac atccttgccc  540
tgtcaccccc tgcccaaaat ttgctactta aatcgtactt ctctgaagaa ggaatcggat  600
ataacatcat ccgggtaccc atggccagct gtgacttctc catccgcacc tacacctatg  660
cagacacccc tgatgatttc cagttgcaca acttcagcct cccagaggaa gataccaagc  720
tcaagatacc cctgattcac cgagccctgc agttggccca gcgtcccgtt tcactccttg  780
ccagcccctg gacatcaccc acttggctca agaccaatgg agcggtgaat gggaaggggt  840
cactcaaggg acagcccgga gacatctacc accagacctg ggccagatac tttgtgaagt  900
tcctggatgc ctatgctgag cacaagttac agttctgggc agtgacagct gaaaatgagc  960
cttctgctgg gctgttgagt ggatacccct tccagtgcct gggcttcacc cctgaacatc 1020
agcgagactt cattgcccgt gacctaggtc ctaccctcgc caacagtact caccacaatg 1080
tccgcctact catgctggat gaccaacgct tgctgctgcc ccactgggca aaggtggtac 1140
tgacagaccc agaagcagct aaatatgttc atggcattgc tgtacattgg tacctggact 1200
ttctggctcc agccaaagcc accctagggg agacacaccg cctgttcccc aacaccatgc 1260
tctttgcctc agaggcctgt gtgggctcca agttctggga gcagagtgtg cggctaggct 1320
cctgggatcg agggatgcag tacagccaca gcatcatcac gaacctcctg taccatgtgg 1380
tcggctggac cgactggaac cttgccctga accccgaagg aggacccaat tgggtgcgta 1440
actttgtcga cagtcccatc attgtagaca tcaccaagga cacgttttac aaacagccca 1500
tgttctacca ccttggccac ttcagcaagt tcattcctga gggctcccag agagtggggc 1560
tggttgccag tcagaagaac gacctggacg cagtggcact gatgcatccc gatggctctg 1620
ctgttgtggt cgtgctaaac cgctcctcta aggatgtgcc tcttaccatc aaggatcctg 1680
ctgtgggctt cctggagaca atctcacctg gctactccat tcacacctac ctgtggcgtc 1740
gccagtgatg gagcagatac tcaaggaggc actgggctca gcctgggcat taaagggaca 1800
gagtcagctc acacgctgtc tgtgactaaa gagggcacag cagggccagt gtgagcttac 1860
agcgacgtaa gcccaggggc aatggtttgg gtgactcact ttcccctcta ggtggtgcca 1920
ggggctggag gcccctagaa aaagatcagt aagccccagt gtccccccag cccccatgct 1980
tatgtgaaca tgcgctgtgt gctgcttgct ttggaaactg ggcctgggtc caggcctagg 2040
gtgagctcac tgtccgtaca aacacaagat cagggctgag ggtaaggaaa agaagagact 2100
aggaaagctg ggcccaaaac tggagactgt ttgtctttcc tggagatgca gaactgggcc 2160
cgtggagcag cagtgtcagc atcagggcgg aagccttaaa gcagcagcgg gtgtgcccag 2220
gcacccagat gattcctatg gcaccagcca ggaaaaatgg cagctcttaa aggagaaaat 2280
gtttgagccc a							  2291

<210>  6
<211>  429
<212>  DNA
<213>  DNA
<221>  alfa-GAL 

<400>  6

MetGlnLeuArgAsnProGluLeuHisLeu GlyCysAlaLeuAlaLeuArgPheLeuAla LeuValSerTrpAspIleProGlyAlaArg AlaLeuAspAsnGlyLeuAlaArgThrPro ThrMetGlyTrpLeuHisTrpGluArgPhe MetCysAsnLeuAspCysGlnGluGluPro  60
AspSerCysIleSerGluLysLeuPheMet GluMetAlaGluLeuMetValSerGluGly TrpLysAspAlaGlyTyrGluTyrLeuCys IleAspAspCysTrpMetAlaProGlnArg AspSerGluGlyArgLeuGlnAlaAspPro GlnArgPheProHisGlyIleArgGlnLeu 120
AlaAsnTyrValHisSerLysGlyLeuLys LeuGlyIleTyrAlaAspValGlyAsnLys ThrCysAlaGlyPheProGlySerPheGly TyrTyrAspIleAspAlaGlnThrPheAla AspTrpGlyValAspLeuLeuLysPheAsp GlyCysTyrCysAspSerLeuGluAsnLeu 180
AlaAspGlyTyrLysHisMetSerLeuAla LeuAsnArgThrGlyArgSerIleValTyr SerCysGluTrpProLeuTyrMetTrpPro PheGlnLysProAsnTyrThrGluIleArg GlnTyrCysAsnHisTrpArgAsnPheAla AspIleAspAspSerTrpLysSerIleLys 240
SerIleLeuAspTrpThrSerPheAsnGln GluArgIleValAspValAlaGlyProGly GlyTrpAsnAspProAspMetLeuValIle GlyAsnPheGlyLeuSerTrpAsnGlnGln ValThrGlnMetAlaLeuTrpAlaIleMet AlaAlaProLeuPheMetSerAsnAspLeu 300
ArgHisIleSerProGlnAlaLysAlaLeu LeuGlnAspLysAspValIleAlaIleAsn GlnAspProLeuGlyLysGlnGlyTyrGln LeuArgGlnGlyAspAsnPheGluValTrp GluArgProLeuSerGlyLeuAlaTrpAla ValAlaMetIleAsnArgGlnGluIleGly 360
GlyProArgSerTyrThrIleAlaValAla SerLeuGlyLysGlyValAlaCysAsnPro AlaCysPheIleThrGlnLeuLeuProVal LysArgLysLeuGlyPheTyrGluTrpThr SerArgLeuArgSerHisIleAsnProThr GlyThrValLeuLeuGlnLeuGluAsnThr 420
MetGlnMetSerLeuLysAspLeuLeu																				  429




