                         б

<110>  ɳƼ޹˾麣Ƽ޹˾ϺɳƼ޹˾麣ɳƼ޹˾

<120>  PD-1弰ƱӦ

<130>  0170-PA-030

<160>  38

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1

<400>  1

Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2

<400>  2

Ile Ser Gly Gly Gly Arg Tyr Thr 
1               5               


<210>  3
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3

<400>  3

Ala Ser Ile Tyr Asp Gly Tyr Tyr Phe Asp Tyr 
1               5                   10      


<210>  4
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1

<400>  4

Gln Ser Ile Ser Asn Asn 
1               5       


<210>  5
<211>  3
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR2

<400>  5

Tyr Ala Ser 
1           


<210>  6
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3

<400>  6

Gln Gln Ser Asn Ser Trp Pro Leu Thr 
1               5                   


<210>  7
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  6H6 VH

<400>  7

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Arg Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ile Tyr Asp Gly Tyr Tyr Phe Asp Tyr Trp Gly His Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  8
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  6H6 VL

<400>  8

Asp Ile Val Ile Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Asn 
            20                  25                  30          


Leu His Trp Tyr Gln Lys Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Thr 
65                  70                  75                  80  


Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  9
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Hu_6H6 VH

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Arg Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ile Tyr Asp Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  10
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Hu_6H6 VL

<400>  10

Glu Ile Val Ile Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Arg Arg Ala Ser Gln Ser Ile Ser Asn Asn 
            20                  25                  30          


Leu His Trp Tyr Gln Lys Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  11
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  6H6 HFR1

<400>  11

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  12
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  6H6 HFR2

<400>  12

Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala 
1               5                   10                  15      


Thr 
    


<210>  13
<211>  37
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  6H6 HFR3

<400>  13

Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ala Lys Asn Asn Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp 
            20                  25                  30          


Thr Ala Leu Tyr Tyr 
        35          


<210>  14
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  6H6 HFR4

<400>  14

Trp Gly His Gly Thr Thr Leu Thr Val Ser Ser 
1               5                   10      


<210>  15
<211>  26
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  6H6 LFR1

<400>  15

Asp Ile Val Ile Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Ser Val Ser Leu Ser Cys Arg Ala Ser 
            20                  25      


<210>  16
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  6H6 LFR2

<400>  16

Leu His Trp Tyr Gln Lys Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
1               5                   10                  15      


Lys 
    


<210>  17
<211>  36
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  6H6 LFR3

<400>  17

Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Thr Glu Asp Phe Gly 
            20                  25                  30          


Met Tyr Phe Cys 
        35      


<210>  18
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  6H6 LFR4

<400>  18

Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
1               5                   10  


<210>  19
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Hu_6H6 HFR1

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  20
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Hu_6H6 HFR2

<400>  20

Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  15      


Thr 
    


<210>  21
<211>  38
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Hu_6H6 HFR3

<400>  21

Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ala Lys Asn Asn Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  22
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Hu_6H6 HFR4

<400>  22

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  23
<211>  26
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Hu_6H6 LFR1

<400>  23

Glu Ile Val Ile Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Arg Arg Ala Ser 
            20                  25      


<210>  24
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Hu_6H6 LFR2

<400>  24

Leu His Trp Tyr Gln Lys Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
1               5                   10                  15      


Lys 
    


<210>  25
<211>  36
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Hu_6H6 LFR3

<400>  25

Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala 
            20                  25                  30          


Met Tyr Phe Cys 
        35      


<210>  26
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Hu_6H6 LFR4

<400>  26

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  27
<211>  327
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  IgG4 CH

<400>  27

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  28
<211>  330
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  IgG1 CH

<400>  28

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  29
<211>  429
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  PD-1 Leu25-Gln167

<400>  29
ttagactccc cagacaggcc ctggaacccc cccaccttct ccccagccct gctcgtggtg       60

accgaagggg acaacgccac cttcacctgc agcttctcca acacatcgga gagcttcgtg      120

ctaaactggt accgcatgag ccccagcaac cagacggaca agctggccgc cttccccgag      180

gaccgcagcc agcccggcca ggactgccgc ttccgtgtca cacaactgcc caacgggcgt      240

gacttccaca tgagcgtggt cagggcccgg cgcaatgaca gcggcaccta cctctgtggg      300

gccatctccc tggcccccaa ggcgcagatc aaagagagcc tgcgggcaga gctcagggtg      360

acagagagaa gggcagaagt gcccacagcc caccccagcc cctcacccag gccagccggc      420

cagttccaa                                                              429


<210>  30
<211>  143
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PD-1 Leu25-Gln167

<400>  30

Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala 
1               5                   10                  15      


Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe 
            20                  25                  30          


Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro 
        35                  40                  45              


Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln 
    50                  55                  60                  


Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg 
65                  70                  75                  80  


Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr 
                85                  90                  95      


Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu 
            100                 105                 110         


Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro 
        115                 120                 125             


Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Phe Gln 
    130                 135                 140             


<210>  31
<211>  18
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  Hisǩ

<400>  31
catcatcacc atcaccat                                                     18


<210>  32
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Hisǩ

<400>  32

His His His His His His 
1               5       


<210>  33
<211>  321
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  Nivolumab VL

<400>  33
gagatcgtcc tgacccagtc tccagccact ctctccctgt ctccaggcga gcgcgctaca       60

ctgagttgta gagcttccca gtccgtgagc agctatctgg cctggtatca gcagaagcct      120

gggcaggctc cacggttgct gatttatgac gcctccaacc gcgcgactgg gataccagct      180

aggttttccg gatcaggcag cggcactgat tttacactga ccatctcatc tctcgagccg      240

gaagatttcg ccgtttacta ttgtcaacag agttcaaact ggccacggac attcggtcag      300

gggaccaagg ttgaaattaa g                                                321


<210>  34
<211>  339
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  Nivolumab VH

<400>  34
caagtccaat tggtggagtc tggcggtggg gtagttcagc ccggccgatc cctgcgcctg       60

gactgcaaag cttctggaat tacgttctca aactccggaa tgcactgggt gcggcaagca      120

cctgggaaag ggctggagtg ggttgcggtg atttggtacg atggctctaa gaggtactac      180

gcagacagcg ttaaaggcag atttactata tcccgagata actctaaaaa tacgctcttc      240

ctccaaatga atagcctgag ggcagaagac acagccgttt actattgtgc taccaatgat      300

gattactggg gacagggcac cctggttacc gtaagttcc                             339


<210>  35
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Nivolumab VL

<400>  35

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  36
<211>  113
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Nivolumab VH

<400>  36

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  37
<211>  1353
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ļPD-L1ͻ

<400>  37
tttactgtca cggttcccaa ggacctatat gtggtagagt atggtagcaa tatgacaatt       60

gaatgcaaat tcccagtaga aaaacaatta gacctggctg cactacaggt cttctggatg      120

atggaggata agaacattat tcaatttgtg catggagagg aagacctgaa ggttcagcat      180

agtagctaca gacagagggc ccggctgttg aaggaccagc tctccctggg aaatgctgca      240

cttcagatca cagatgtgaa attgcaggat gcaggggtgt acacctgcct gatcgcatat      300

aagggtgccg actacaagcg aattactgtg aaagtcaatg ccccatacaa caaaatcaac      360

caaagaattt tggttgtgga tccagtcacc tctgaacatg aactgacatg tcaggctgag      420

ggctacccca aggccgaagt catctggaca agcagtgacc atcaagtcct gagtggtaag      480

accaccacca ccaattccaa gagagaggag aagcttttca atgtgaccag cacactgaga      540

atcaacacaa caactaatga gattttctac tgcactttta ggagattaga tcctgaggaa      600

aaccatacag ctgaattggt catcccagaa ctacctctgg cacatcctcc aaatgaaagg      660

ggctcaggat ctggcaatgg gagtcctaga gcctttactg tcacggttcc caaggaccta      720

tatgtggtag agtatggtag caatatgaca attgaatgca aattcccagt agaaaaacaa      780

ttagacctgg ctgcactaca ggtcttctgg atgatggagg ataagaacat tattcaattt      840

gtgcatggag aggaagacct gaaggttcag catagtagct acagacagag ggcccggctg      900

ttgaaggacc agctctccct gggaaatgct gcacttcaga tcacagatgt gaaattgcag      960

gatgcagggg tgtacacctg cctgatcgca tataagggtg ccgactacaa gcgaattact     1020

gtgaaagtca atgccccata caacaaaatc aaccaaagaa ttttggttgt ggatccagtc     1080

acctctgaac atgaactgac atgtcaggct gagggctacc ccaaggccga agtcatctgg     1140

acaagcagtg accatcaagt cctgagtggt aagaccacca ccaccaattc caagagagag     1200

gagaagcttt tcaatgtgac cagcacactg agaatcaaca caacaactaa tgagattttc     1260

tactgcactt ttaggagatt agatcctgag gaaaaccata cagctgaatt ggtcatccca     1320

gaactacctc tggcacatcc tccaaatgaa agg                                  1353


<210>  38
<211>  451
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  ļPD-L1ͻ就

<400>  38

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Gln Val Phe Trp Met Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Thr Cys 
                85                  90                  95      


Leu Ile Ala Tyr Lys Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Gly Ser Gly Ser 
    210                 215                 220                 


Gly Asn Gly Ser Pro Arg Ala Phe Thr Val Thr Val Pro Lys Asp Leu 
225                 230                 235                 240 


Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro 
                245                 250                 255     


Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Gln Val Phe Trp Met Met 
            260                 265                 270         


Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys 
        275                 280                 285             


Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln 
    290                 295                 300                 


Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln 
305                 310                 315                 320 


Asp Ala Gly Val Tyr Thr Cys Leu Ile Ala Tyr Lys Gly Ala Asp Tyr 
                325                 330                 335     


Lys Arg Ile Thr Val Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln 
            340                 345                 350         


Arg Ile Leu Val Val Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys 
        355                 360                 365             


Gln Ala Glu Gly Tyr Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp 
    370                 375                 380                 


His Gln Val Leu Ser Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu 
385                 390                 395                 400 


Glu Lys Leu Phe Asn Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr 
                405                 410                 415     


Asn Glu Ile Phe Tyr Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn 
            420                 425                 430         


His Thr Ala Glu Leu Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro 
        435                 440                 445             


Asn Glu Arg 
    450     



