                         б

<110>  йѧԺо
       ϸҽѧоԺ
 
<120>  EGFRǶϿԭ

<130>  P2021TC1774

<150>  202011062635.6
<151>  2020-09-30

<160>  82    

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu806 VH-CDR1

<400>  1

Ser Asp Phe Ala Trp Asn 
1               5       


<210>  2
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu806 VH-CDR2

<400>  2

Tyr Ile Ser Tyr Ser Gly Asn Thr Arg Tyr Gln Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu806 VH-CDR3

<400>  3

Val Thr Ala Gly Arg Gly Phe Pro Tyr 
1               5                   


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu806 VL-CDR1

<400>  4

His Ser Ser Gln Asp Ile Asn Ser Asn Ile Gly 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu806 VL-CDR2

<400>  5

His Gly Thr Asn Leu Asp Asp 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu806 VL-CDR3

<400>  6

Val Gln Tyr Ala Gln Phe Pro Trp Thr 
1               5                   


<210>  7
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu806 VH

<400>  7

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Ser Ser Asp 
            20                  25                  30          


Phe Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Asn Thr Arg Tyr Gln Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Thr Ala Gly Arg Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  8
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu806 VL

<400>  8

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ser Ser Gln Asp Ile Asn Ser Asn 
            20                  25                  30          


Ile Gly Trp Leu Gln Gln Lys Pro Gly Lys Ser Phe Lys Gly Leu Ile 
        35                  40                  45              


Tyr His Gly Thr Asn Leu Asp Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gln Tyr Ala Gln Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  9
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu806 ScFv

<400>  9

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Ser Ser Asp 
            20                  25                  30          


Phe Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Asn Thr Arg Tyr Gln Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Thr Ala Gly Arg Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser Val 
    130                 135                 140                 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys His Ser Ser Gln Asp Ile 
145                 150                 155                 160 


Asn Ser Asn Ile Gly Trp Leu Gln Gln Lys Pro Gly Lys Ser Phe Lys 
                165                 170                 175     


Gly Leu Ile Tyr His Gly Thr Asn Leu Asp Asp Gly Val Pro Ser Arg 
            180                 185                 190         


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser 
        195                 200                 205             


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gln Tyr Ala Gln 
    210                 215                 220                 


Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
225                 230                 235                 


<210>  10
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E2 VH-CDR1

<400>  10

Asn Tyr Asp Met 
1               


<210>  11
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E2 VH-CDR2

<400>  11

Gly Ile Ser His Ser Ser Gly Ser Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E2 VH-CDR3

<400>  12

Lys Asp Ala Thr Pro Arg Pro Leu Lys Pro Phe Asp Tyr 
1               5                   10              


<210>  13
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E2 VL-CDR1

<400>  13

Thr Gly Ser Ser Ser Asn Ile Gly Asn Asn Asp Val Ser 
1               5                   10              


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E2 VL-CDR2

<400>  14

Asp Asp Asn Lys Arg Pro Ser 
1               5           


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E2 VL-CDR3

<400>  15

Gly Ser Trp Asp Ala Ser Leu Asn Ala 
1               5                   


<210>  16
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E2 VH

<400>  16

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser His Ser Ser Gly Ser Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Ala Thr Pro Arg Pro Leu Lys Pro Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  17
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E2 VL

<400>  17

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Asp Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asp Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Trp Asp Ala Ser Leu 
                85                  90                  95      


Asn Ala Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  18
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E2 ScFv

<400>  18

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser His Ser Ser Gly Ser Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Ala Thr Pro Arg Pro Leu Lys Pro Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro 
    130                 135                 140                 


Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly 
145                 150                 155                 160 


Ser Ser Ser Asn Ile Gly Asn Asn Asp Val Ser Trp Tyr Gln Gln Leu 
                165                 170                 175     


Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Asp Asp Asn Lys Arg Pro 
            180                 185                 190         


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala 
        195                 200                 205             


Ser Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr 
    210                 215                 220                 


Cys Gly Ser Trp Asp Ala Ser Leu Asn Ala Tyr Val Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Leu Thr Val Leu Gly 
                245         


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pan VH-CDR1

<400>  19

Ser Gly Asp Tyr Tyr Trp Thr 
1               5           


<210>  20
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pan VH-CDR2

<400>  20

His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  21
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pan VH-CDR3

<400>  21

Asp Arg Val Thr Gly Ala Phe Asp Ile 
1               5                   


<210>  22
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pan VL-CDR1

<400>  22

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pan VL-CDR2

<400>  23

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pan VL-CDR3

<400>  24

Gln His Phe Asp His Leu Pro Leu Ala 
1               5                   


<210>  25
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pan VH

<400>  25

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Val Arg Asp Arg Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg 
    130                 135 


<210>  26
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pan VL

<400>  26

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Asp His Leu Pro Leu 
                85                  90                  95      


Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  27
<211>  257
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pan ScFv

<400>  27

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Val Arg Asp Arg Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
145                 150                 155                 160 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
                165                 170                 175     


Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
            180                 185                 190         


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val 
        195                 200                 205             


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
    210                 215                 220                 


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys Gln His 
225                 230                 235                 240 


Phe Asp His Leu Pro Leu Ala Phe Gly Gly Gly Thr Lys Val Glu Ile 
                245                 250                 255     


Lys 
    


<210>  28
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nec VH-CDR1

<400>  28

Ser Gly Asp Tyr Tyr Trp Ser 
1               5           


<210>  29
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nec VH-CDR2

<400>  29

Tyr Ile Tyr Tyr Ser Gly Ser Thr Asp Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  30
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nec VH-CDR3

<400>  30

Val Ser Ile Phe Gly Val Gly Thr Phe Asp Tyr 
1               5                   10      


<210>  31
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nec VL-CDR1

<400>  31

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  32
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nec VL-CDR2

<400>  32

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nec VL-CDR3

<400>  33

His Gln Tyr Gly Ser Thr Pro Leu Thr 
1               5                   


<210>  34
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nec VH

<400>  34

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asp Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Val Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Val Ser Ile Phe Gly Val Gly Thr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  35
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nec VL

<400>  35

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr Gly Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Ala Glu Ile Lys 
            100                 105         


<210>  36
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nec ScFv

<400>  36

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asp Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Val Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Val Ser Ile Phe Gly Val Gly Thr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
    130                 135                 140                 


Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr 
            180                 185                 190         


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
    210                 215                 220                 


His Gln Tyr Gly Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Ala 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  37
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nimo VH-CDR1

<400>  37

Arg Ser Ser Gln Asn Ile Val His Ser Asn Gly Asn Thr Tyr Leu Asp 
1               5                   10                  15      


<210>  38
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nimo VH-CDR2

<400>  38

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  39
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nimo VH-CDR3

<400>  39

Phe Gln Tyr Ser His Val Pro Trp Thr 
1               5                   


<210>  40
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nimo VL-CDR1

<400>  40

Asn Tyr Tyr Ile Tyr 
1               5   


<210>  41
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nimo VL-CDR2

<400>  41

Gly Gly Ile Asn Pro Thr Ser Gly Gly Ser Asn Phe Asn Glu Lys Phe 
1               5                   10                  15      


Lys Thr 
        


<210>  42
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nimo VL-CDR3

<400>  42

Gln Gly Leu Trp Phe Asp Ser Asp Gly Arg Gly Phe Asp Phe 
1               5                   10                  


<210>  43
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nimo VH

<400>  43

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Ile Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Thr Ser Gly Gly Ser Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Thr Arg Val Thr Ile Thr Val Asp Glu Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Phe Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gln Gly Leu Trp Phe Asp Ser Asp Gly Arg Gly Phe Asp Phe 
            100                 105                 110         


Trp Gly Gln Gly Ser Thr Val Thr Val Ser Ser 
        115                 120             


<210>  44
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nimo VL

<400>  44

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Asn Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Asp Trp Tyr Gln Gln Thr Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Phe Gln Tyr 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr 
            100                 105                 110         


Arg Glu 
        


<210>  45
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nimo ScFv

<400>  45

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Asn Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Asp Trp Tyr Gln Gln Thr Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Phe Gln Tyr 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr 
            100                 105                 110         


Arg Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
    130                 135                 140                 


Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn 
145                 150                 155                 160 


Tyr Tyr Ile Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
                165                 170                 175     


Ile Gly Gly Ile Asn Pro Thr Ser Gly Gly Ser Asn Phe Asn Glu Lys 
            180                 185                 190         


Phe Lys Thr Arg Val Thr Ile Thr Val Asp Glu Ser Thr Asn Thr Ala 
        195                 200                 205             


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Phe Tyr Phe 
    210                 215                 220                 


Cys Ala Arg Gln Gly Leu Trp Phe Asp Ser Asp Gly Arg Gly Phe Asp 
225                 230                 235                 240 


Phe Trp Gly Gln Gly Ser Thr Val Thr Val Ser Ser 
                245                 250         


<210>  46
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  301 VH CDR1

<400>  46

Gly Thr Phe Ser Ser Tyr Ala 
1               5           


<210>  47
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  301 VH CDR2

<400>  47

Ile Ile Pro Ile Phe Gly Thr Ala 
1               5               


<210>  48
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  301 VH CDR3

<400>  48

Ala Arg Thr Arg Leu Lys His Gln 
1               5               


<210>  49
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  301 VL CDR1

<400>  49

Ser Leu Arg Ser Tyr Tyr 
1               5       


<210>  50
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  301 VL CDR2

<400>  50

Gly Lys Asn Asn 
1               


<210>  51
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  301 VL CDR3

<400>  51

Asn Ser Arg Asp Ser Ser Gly Pro Val 
1               5                   


<210>  52
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  301 VH

<400>  52

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Arg Leu Lys His Gln Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  53
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  301 VL

<400>  53

Leu Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly 
1               5                   10                  15      


Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr 
            20                  25                  30          


Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile 
        35                  40                  45              


Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala 
65                  70                  75                  80  


Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Pro 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala Ala Ala 
            100                 105                 110     


<210>  54
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  301 ScFv

<400>  54

Met Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
1               5                   10                  15      


Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser 
            20                  25                  30          


Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Met Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln 
    50                  55                  60                  


Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr 
65                  70                  75                  80  


Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Thr Arg Leu Lys His Gln Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val 
    130                 135                 140                 


Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg 
145                 150                 155                 160 


Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
                165                 170                 175     


Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg 
            180                 185                 190         


Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly 
        195                 200                 205             


Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser 
    210                 215                 220                 


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala 
225                 230                 235                 240 


Ala Ala 
        


<210>  55
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 ź

<400>  55

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  56
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 

<400>  56

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        35                  40                  


<210>  57
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 Ĥ

<400>  57

Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
1               5                   10                  15      


Leu Val Ile Thr Leu Tyr Cys 
            20              


<210>  58
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BBʽṹ

<400>  58

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  59
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3

<400>  59

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  60
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu806 CAR

<400>  60

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr 
        35                  40                  45              


Ser Ile Ser Ser Asp Phe Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Met Gly Tyr Ile Ser Tyr Ser Gly Asn Thr Arg 
65                  70                  75                  80  


Tyr Gln Pro Ser Leu Lys Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Phe Phe Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr 
            100                 105                 110         


Ala Thr Tyr Tyr Cys Val Thr Ala Gly Arg Gly Phe Pro Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
145                 150                 155                 160 


Ser Ser Met Ser Val Ser Val Gly Asp Arg Val Thr Ile Thr Cys His 
                165                 170                 175     


Ser Ser Gln Asp Ile Asn Ser Asn Ile Gly Trp Leu Gln Gln Lys Pro 
            180                 185                 190         


Gly Lys Ser Phe Lys Gly Leu Ile Tyr His Gly Thr Asn Leu Asp Asp 
        195                 200                 205             


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
    210                 215                 220                 


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
225                 230                 235                 240 


Val Gln Tyr Ala Gln Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
                245                 250                 255     


Glu Ile Lys Arg Thr Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
            260                 265                 270         


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
        275                 280                 285             


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
    290                 295                 300                 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
305                 310                 315                 320 


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys 
                325                 330                 335     


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
            340                 345                 350         


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
        355                 360                 365             


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            420                 425                 430         


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        435                 440                 445             


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    450                 455                 460                 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
465                 470                 475                 480 


Ala Leu Pro Pro Arg 
                485 


<210>  61
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E2 CAR

<400>  61

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Asn Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Gly Ile Ser His Ser Ser Gly Ser Lys Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Lys Asp Ala Thr Pro Arg Pro Leu Lys Pro 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val 
145                 150                 155                 160 


Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr 
                165                 170                 175     


Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Asn Asn Asp Val Ser 
            180                 185                 190         


Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Asp 
        195                 200                 205             


Asp Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys 
    210                 215                 220                 


Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp 
225                 230                 235                 240 


Glu Ala Asp Tyr Tyr Cys Gly Ser Trp Asp Ala Ser Leu Asn Ala Tyr 
                245                 250                 255     


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Arg Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  62
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pan CAR

<400>  62

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly 
        35                  40                  45              


Ser Val Ser Ser Gly Asp Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr 
65                  70                  75                  80  


Asn Tyr Asn Pro Ser Leu Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr 
                85                  90                  95      


Ser Lys Thr Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Ile Tyr Tyr Cys Val Arg Asp Arg Val Thr Gly Ala Phe Asp 
        115                 120                 125             


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
                165                 170                 175     


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
            180                 185                 190         


Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln 
        195                 200                 205             


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn 
    210                 215                 220                 


Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
225                 230                 235                 240 


Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
                245                 250                 255     


Tyr Phe Cys Gln His Phe Asp His Leu Pro Leu Ala Phe Gly Gly Gly 
            260                 265                 270         


Thr Lys Val Glu Ile Lys Thr Arg Thr Thr Thr Pro Ala Pro Arg Pro 
        275                 280                 285             


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
    290                 295                 300                 


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
305                 310                 315                 320 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
                325                 330                 335     


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
            340                 345                 350         


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
        355                 360                 365             


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
    370                 375                 380                 


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
385                 390                 395                 400 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
                405                 410                 415     


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
            420                 425                 430         


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
        435                 440                 445             


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
    450                 455                 460                 


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
465                 470                 475                 480 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
                485                 490                 495     


Met Gln Ala Leu Pro Pro Arg 
            500             


<210>  63
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nec CAR

<400>  63

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly 
        35                  40                  45              


Ser Ile Ser Ser Gly Asp Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr 
65                  70                  75                  80  


Asp Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Met Ser Val Asp Thr 
                85                  90                  95      


Ser Lys Asn Gln Phe Ser Leu Lys Val Asn Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Val Ser Ile Phe Gly Val Gly Thr 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val 
145                 150                 155                 160 


Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
                165                 170                 175     


Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp 
            180                 185                 190         


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala 
        195                 200                 205             


Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys His Gln Tyr Gly Ser Thr Pro Leu Thr Phe Gly 
                245                 250                 255     


Gly Gly Thr Lys Ala Glu Ile Lys Thr Arg Thr Thr Thr Pro Ala Pro 
            260                 265                 270         


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
        275                 280                 285             


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
    290                 295                 300                 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
305                 310                 315                 320 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
                325                 330                 335     


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
            340                 345                 350         


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
        355                 360                 365             


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 


<210>  64
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nimo CAR

<400>  64

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln 
        35                  40                  45              


Asn Ile Val His Ser Asn Gly Asn Thr Tyr Leu Asp Trp Tyr Gln Gln 
    50                  55                  60                  


Thr Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Phe Gln Tyr Ser His Val Pro Trp Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Leu Gln Ile Thr Arg Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
145                 150                 155                 160 


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Tyr Thr Phe Thr Asn Tyr Tyr Ile Tyr Trp Val Arg Gln Ala Pro Gly 
            180                 185                 190         


Gln Gly Leu Glu Trp Ile Gly Gly Ile Asn Pro Thr Ser Gly Gly Ser 
        195                 200                 205             


Asn Phe Asn Glu Lys Phe Lys Thr Arg Val Thr Ile Thr Val Asp Glu 
    210                 215                 220                 


Ser Thr Asn Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
225                 230                 235                 240 


Thr Ala Phe Tyr Phe Cys Ala Arg Gln Gly Leu Trp Phe Asp Ser Asp 
                245                 250                 255     


Gly Arg Gly Phe Asp Phe Trp Gly Gln Gly Ser Thr Val Thr Val Ser 
            260                 265                 270         


Ser Thr Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
        275                 280                 285             


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
    290                 295                 300                 


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
305                 310                 315                 320 


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
                325                 330                 335     


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
            340                 345                 350         


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
        355                 360                 365             


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
    370                 375                 380                 


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
385                 390                 395                 400 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
                405                 410                 415     


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
            420                 425                 430         


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
        435                 440                 445             


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
    450                 455                 460                 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
465                 470                 475                 480 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
                485                 490                 495     


Pro Arg 
        


<210>  65
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  301 CAR

<400>  65

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Ala Gln Val Gln Leu Val Gln Ser Gly Ala 
            20                  25                  30          


Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser 
        35                  40                  45              


Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro 
    50                  55                  60                  


Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly Thr 
65                  70                  75                  80  


Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp 
                85                  90                  95      


Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Thr Arg Leu Lys His Gln Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp 
145                 150                 155                 160 


Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln 
                165                 170                 175     


Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro 
            180                 185                 190         


Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser 
        195                 200                 205             


Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser 
    210                 215                 220                 


Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
225                 230                 235                 240 


Asn Ser Arg Asp Ser Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu 
                245                 250                 255     


Thr Val Leu Gly Ala Ala Ala Thr Arg Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
                325                 330                 335     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            340                 345                 350         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        355                 360                 365             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg 
                485             


<210>  66
<211>  1458
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu806 CAR

<400>  66
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcaggtgc agctccaaga gagtggacct gggcttgtca agccgagtca aactttgtcc      120

ctaacatgta ctgtgtccgg atactctatc tcatcagatt ttgcgtggaa ttggataagg      180

cagccaccag ggaaaggttt agaatggatg ggctacatat catactctgg gaacaccaga      240

tatcaacctt ctctgaaaag ccggatcaca atctcaaggg acacgtcgaa gaatcagttc      300

ttcctgaaac tgaactccgt tacagccgca gacacagcaa catattactg cgtaaccgct      360

ggcagaggct tcccctattg gggacagggc accctagtga cagtgagcag cggtggcggt      420

ggctcgggcg gtggtgggtc gggtggcggc ggatctgata ttcagatgac tcagagtcca      480

tccagcatgt cagtctccgt gggagatagg gtgacgataa cctgtcattc aagccaagac      540

atcaactcca atattggatg gctccaacag aagcctggta agtccttcaa aggactaatc      600

tatcacggaa caaacttgga cgacggcgtg ccatcgagat tttcagggtc tggcagcggg      660

accgactata cactgaccat ctctagctta caaccagagg actttgccac atactactgc      720

gtccagtacg ctcagttccc ctggacattc ggcggcggca caaaactgga aatcaaacgt      780

acgcgtacca cgacgccagc gccgcgacca ccaacaccgg cgcccaccat cgcgtcgcag      840

cccctgtccc tgcgcccaga ggcgtgccgg ccagcggcgg ggggcgcagt gcacacgagg      900

gggctggact tcgcctgtga tatctacatc tgggcgccct tggccgggac ttgtggggtc      960

cttctcctgt cactggttat caccctttac tgcaaacggg gcagaaagaa actcctgtat     1020

atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc     1080

tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcaggagc     1140

gcagacgccc ccgcgtacca gcagggccag aaccagctct ataacgagct caatctagga     1200

cgaagagagg agtacgatgt tttggacaag agacgtggcc gggaccctga gatgggggga     1260

aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg     1320

gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat     1380

ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag     1440

gccctgcccc ctcgctaa                                                   1458


<210>  67
<211>  1482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E2 CAR

<400>  67
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctgttgga gtctggggga ggcttggtac agcctggggg gtccctgaga      120

ctctcctgtg cagcctctgg attcaccttt agcaattatg atatgagctg ggtccgccag      180

gctccaggga aggggctgga gtgggtctca gggatctctc atagtagtgg tagtaaatat      240

tacgctgatt ctgtaaaagg tcggttcacc atctccagag acaattccaa gaacacgctg      300

tatctgcaaa tgaacagcct gagagccgag gacacggccg tgtattactg tgcgaaagat      360

gctactccgc gtccgctgaa gcctttcgac tactggggcc agggtacact ggtcaccgtg      420

agctcaggtg gcggtggctc gggcggtggt gggtcgggtg gcggcggatc tcagtctgtg      480

ctgactcagc caccctcagc gtctgggacc cccgggcaga gggtcaccat ctcttgtact      540

ggctcttcat ctaatattgg caataatgat gtctcctggt accagcagct cccaggaacg      600

gcccccaaac tcctcatcta tgatgataat aagcggccaa gcggggtccc tgaccgattc      660

tctggctcca aatctggcac ctcagcctcc ctggccatca gtgggctccg gtccgaggat      720

gaggctgatt attactgtgg ttcttgggat gctagcctga atgcttatgt cttcggcgga      780

ggcaccaagc tgacggtcct aggcacgcgt accacgacgc cagcgccgcg accaccaaca      840

ccggcgccca ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg      900

gcggggggcg cagtgcacac gagggggctg gacttcgcct gtgatatcta catctgggcg      960

cccttggccg ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcaaa     1020

cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact     1080

actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa     1140

ctgagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag     1200

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt     1260

ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgtac     1320

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag     1380

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac     1440

acctacgacg cccttcacat gcaggccctg ccccctcgct aa                        1482


<210>  68
<211>  1512
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pan CAR

<400>  68
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcaggtgc aacttcaaga gagcggccct ggacttgtga aacccagcga aaccctgagc      120

ctgacatgta ccgtgagcgg aggaagcgtg agcagcggag actactactg gacctggatc      180

agacagagcc ccggaaaagg ccttgaatgg atcggccaca tctactacag cggcaacacc      240

aactacaacc ccagcctgaa gagcagactg accatcagca tcgacaccag caagacccag      300

ttcagcctga agctgagcag cgtgacagct gctgacaccg ctatctacta ctgcgtgaga      360

gacagagtga ccggcgcttt cgatatttgg ggccagggaa caatggtgac cgtgagcagc      420

gctagcacaa aaggccctag cgtgtttcct cttgccccct gtagcagagg tggcggtggc      480

tcgggcggtg gtgggtcggg tggcggcgga tctgacatcc agatgacaca gagccctagc      540

agcctgtctg ctagcgttgg agacagagtg accatcacct gtcaagccag ccaggacatc      600

agcaactacc tgaactggta ccagcagaaa cctggcaagg ctcccaaact gctgatttac      660

gacgccagca atctggaaac aggcgtgcct agcagattta gcggcagcgg aagcggaacc      720

gatttcacct tcaccatcag cagcctgcag cccgaagaca ttgccaccta cttctgccag      780

cacttcgatc atctgcccct ggcctttgga ggaggaacaa aggtggagat caagacgcgt      840

accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg      900

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      960

gacttcgcct gtgatatcta catctgggcg cccttggccg ggacttgtgg ggtccttctc     1020

ctgtcactgg ttatcaccct ttactgcaaa cggggcagaa agaaactcct gtatatattc     1080

aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga     1140

tttccagaag aagaagaagg aggatgtgaa ctgagagtga agttcagcag gagcgcagac     1200

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga     1260

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg     1320

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag     1380

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt     1440

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg     1500

ccccctcgct aa                                                         1512


<210>  69
<211>  1470
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nec CAR

<400>  69
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcaggtgc agctgcagga gtcgggccca ggactggtga agccttcaca gaccctgtcc      120

ctcacctgca ctgtctctgg tggctccatc agcagtggtg attactactg gagttggatc      180

cgccagcccc cagggaaggg cctggagtgg attgggtaca tctattacag tgggagcacc      240

gactacaacc cgtccctcaa gagtcgagtc accatgtccg tagacacgtc caagaatcag      300

ttttccctga aggtcaactc tgtgaccgcc gcagacacgg ctgtgtatta ctgtgcgaga      360

gtgtcgattt ttggagtggg gacatttgac tactggggcc agggcaccct ggtcaccgtc      420

tcaagcggtg gcggtggctc gggcggtggt gggtcgggtg gcggcggatc tgaaattgtg      480

atgacacagt ctccagccac cctgtctttg tctccagggg aaagagccac cctctcctgc      540

agggccagtc agagtgttag cagctactta gcctggtacc aacagaaacc tggccaggct      600

cccaggctcc tcatctatga tgcatccaac agggccactg gcatcccagc caggttcagt      660

ggcagtgggt ctgggacaga cttcactctc accatcagca gcctagagcc tgaagatttt      720

gcagtgtatt actgtcacca gtatggtagc acacctctca ctttcggcgg agggaccaag      780

gcggagatca aaacgcgtac cacgacgcca gcgccgcgac caccaacacc ggcgcccacc      840

atcgcgtcgc agcccctgtc cctgcgccca gaggcgtgcc ggccagcggc ggggggcgca      900

gtgcacacga gggggctgga cttcgcctgt gatatctaca tctgggcgcc cttggccggg      960

acttgtgggg tccttctcct gtcactggtt atcacccttt actgcaaacg gggcagaaag     1020

aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa     1080

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact gagagtgaag     1140

ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc agaaccagct ctataacgag     1200

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct     1260

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag     1320

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc     1380

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     1440

cttcacatgc aggccctgcc ccctcgctaa                                      1470


<210>  70
<211>  1497
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nimo CAR

<400>  70
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgaccca gagcccaagc agcctgagcg ccagcgtggg tgacagagtg      120

accatcacct gtagatctag tcagaacatt gtacatagta atggaaacac ctatttagac      180

tggtaccagc agacgccagg taaggctcca aagctgctga tctacaaagt ttccaaccga      240

tttagcggtg tgccaagcag attcagcggt agcggtagcg gtaccgactt caccttcacc      300

atcagcagcc tccagccaga ggacatcgcc acctactact gctttcaata ctcacatgtt      360

ccgtggacgt ttggtcaggg tactaagctt caaatcacta gggaaggtgg cggtggctcg      420

ggcggtggtg ggtcgggtgg cggcggatct caggtccaac tgcagcagtc tggggctgaa      480

gtgaagaagc ctgggtcatc agtgaaggtg tcctgcaagg cttctggcta caccttcacc      540

aactactata tttactgggt gcgacaggcc cctggacaag ggcttgagtg gattggaggg      600

attaatccta ctagcggtgg tagcaacttc aatgagaagt tcaagactag agtgaccatc      660

accgtggacg aatccacgaa cacagcctac atggagctga gcagcctgag atctgaggac      720

acggccttct atttctgtgc gagacaaggg ctttggtttg atagcgatgg gcgaggtttt      780

gatttctggg gccaagggtc tacggtcacc gtctcctcaa cgcgtaccac gacgccagcg      840

ccgcgaccac caacaccggc gcccaccatc gcgtcgcagc ccctgtccct gcgcccagag      900

gcgtgccggc cagcggcggg gggcgcagtg cacacgaggg ggctggactt cgcctgtgat      960

atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc     1020

accctttact gcaaacgggg cagaaagaaa ctcctgtata tattcaaaca accatttatg     1080

agaccagtac aaactactca agaggaagat ggctgtagct gccgatttcc agaagaagaa     1140

gaaggaggat gtgaactgag agtgaagttc agcaggagcg cagacgcccc cgcgtaccag     1200

cagggccaga accagctcta taacgagctc aatctaggac gaagagagga gtacgatgtt     1260

ttggacaaga gacgtggccg ggaccctgag atggggggaa agccgagaag gaagaaccct     1320

caggaaggcc tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt     1380

gggatgaaag gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt     1440

acagccacca aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgctaa        1497


<210>  71
<211>  1467
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  301 CAR

<400>  71
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgatggccc aggtgcagct ggtgcagtct ggggctgagg tgaagaagcc tgggtcctcg      120

gtgaaggtct cctgcaaggc ttctggaggc accttcagca gctatgctat cagctgggtg      180

cgacaggccc ctggacaagg gcttgagtgg atgggaggga tcatccctat ctttggtaca      240

gcaaactacg cacagaagtt ccagggcaga gtcacgatta ccgcggacga atccacgagc      300

acagcctaca tggagctgag cagcctgaga tctgaggaca cggccgtgta ttactgtgca      360

agaactcggc ttaagcatca gtggggccaa ggtaccctgg tcaccgtctc gagtggtgga      420

ggcggttcag gcggaggtgg ctctggcggt agtgcacttt cttctgagct gactcaggac      480

cctgctgtgt ctgtggcctt gggacagaca gtcaggatca catgccaagg agacagcctc      540

agaagctatt atgcaagctg gtaccagcag aagccaggac aggcccctgt acttgtcatc      600

tatggtaaaa acaaccggcc ctcagggatc ccagaccgat tctctggctc cagctcagga      660

aacacagctt ccttgaccat cactggggct caggcggaag atgaggctga ctattactgt      720

aactcccggg acagcagtgg tccggtattc ggcggaggga ccaagctgac cgtcctaggt      780

gcggccgcaa cgcgtaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc      840

gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg      900

cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact      960

tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa     1020

ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat     1080

ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc     1140

agcaggagcg cagacgcccc cgcgtaccag cagggccaga accagctcta taacgagctc     1200

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag     1260

atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1320

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1380

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1440

cacatgcagg ccctgccccc tcgctaa                                         1467


<210>  72
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ľͷ

<400>  72

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  73
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m806 ScFv

<400>  73

Asp Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Phe Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Asn Thr Arg Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Ile Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Thr Ala Gly Arg Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Met Ser Val 
    130                 135                 140                 


Ser Leu Gly Asp Thr Val Ser Ile Thr Cys His Ser Ser Gln Asp Ile 
145                 150                 155                 160 


Asn Ser Asn Ile Gly Trp Leu Gln Gln Arg Pro Gly Lys Ser Phe Lys 
                165                 170                 175     


Gly Leu Ile Tyr His Gly Thr Asn Leu Asp Asp Glu Val Pro Ser Arg 
            180                 185                 190         


Phe Ser Gly Ser Gly Ser Gly Ala Asp Tyr Ser Leu Thr Ile Ser Ser 
        195                 200                 205             


Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr Ala Gln 
    210                 215                 220                 


Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
225                 230                 235                 


<210>  74
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  m806 ScFv

<400>  74
gatgtgcagc ttcaggagtc gggacctagc ctggtgaaac cttctcagtc tctgtccctc       60

acctgcactg tcactggcta ctcaatcacc agtgattttg cctggaactg gatccggcag      120

tttccaggaa acaagctgga gtggatgggc tacataagtt atagtggtaa cactaggtac      180

aacccatctc tcaaaagtcg aatctctatc actcgagaca catccaagaa ccaattcttc      240

ctgcagttga attctgtgac tattgaggac acagccacat attactgtgt aacggcggga      300

cgcgggtttc cttattgggg ccaagggact ctggtcactg tctctgcagg tggcggtggc      360

tcgggcggtg gtgggtcggg tggcggcgga tctgacatcc tgatgaccca atctccatcc      420

tccatgtctg tatctctggg agacacagtc agcatcactt gccattcaag tcaggacatt      480

aacagtaata tagggtggtt gcagcagaga ccagggaaat catttaaggg cctgatctat      540

catggaacca acttggacga tgaagttcca tcaaggttca gtggcagtgg atctggagcc      600

gattattctc tcaccatcag cagcctggaa tctgaagatt ttgcagacta ttactgtgta      660

cagtatgctc agtttccgtg gacgttcggt ggaggcacca agctggaaat caaacgt         717


<210>  75
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   m806 ScFv VH CDR1

<400>  75

Ser Asp Phe Ala Trp Asn 
1               5       


<210>  76
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m806 ScFv VH CDR2

<400>  76

Tyr Ile Ser Tyr Ser Gly Asn Thr Arg Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  77
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m806 ScFv VH CDR3

<400>  77

Val Thr Ala Gly Arg Gly Phe Pro Tyr 
1               5                   


<210>  78
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m806 ScFv VL CDR1

<400>  78

His Ser Ser Gln Asp Ile Asn Ser Asn Ile Gly 
1               5                   10      


<210>  79
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m806 ScFv VL CDR2

<400>  79

His Gly Thr Asn Leu Asp Asp 
1               5           


<210>  80
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m806 ScFv VL CDR3

<400>  80

Val Gln Tyr Ala Gln Phe Pro Trp Thr 
1               5                   


<210>  81
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m806 CAR

<400>  81

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Val Gln Leu Gln Glu Ser Gly Pro Ser Leu 
            20                  25                  30          


Val Lys Pro Ser Gln Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr 
        35                  40                  45              


Ser Ile Thr Ser Asp Phe Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly 
    50                  55                  60                  


Asn Lys Leu Glu Trp Met Gly Tyr Ile Ser Tyr Ser Gly Asn Thr Arg 
65                  70                  75                  80  


Tyr Asn Pro Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Phe Phe Leu Gln Leu Asn Ser Val Thr Ile Glu Asp Thr 
            100                 105                 110         


Ala Thr Tyr Tyr Cys Val Thr Ala Gly Arg Gly Phe Pro Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Leu Met Thr Gln Ser Pro 
145                 150                 155                 160 


Ser Ser Met Ser Val Ser Leu Gly Asp Thr Val Ser Ile Thr Cys His 
                165                 170                 175     


Ser Ser Gln Asp Ile Asn Ser Asn Ile Gly Trp Leu Gln Gln Arg Pro 
            180                 185                 190         


Gly Lys Ser Phe Lys Gly Leu Ile Tyr His Gly Thr Asn Leu Asp Asp 
        195                 200                 205             


Glu Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Ala Asp Tyr Ser 
    210                 215                 220                 


Leu Thr Ile Ser Ser Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys 
225                 230                 235                 240 


Val Gln Tyr Ala Gln Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
                245                 250                 255     


Glu Ile Lys Arg Thr Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
            260                 265                 270         


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
        275                 280                 285             


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
    290                 295                 300                 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
305                 310                 315                 320 


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys 
                325                 330                 335     


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
            340                 345                 350         


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
        355                 360                 365             


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            420                 425                 430         


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        435                 440                 445             


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    450                 455                 460                 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
465                 470                 475                 480 


Ala Leu Pro Pro Arg 
                485 


<210>  82
<211>  1470
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  m806 CAR

<400>  82
ggatccatgg ccttaccagt gaccgccttg ctcctgccgc tggccttgct gctccacgcc       60

gccaggccgg atgtgcagct tcaggagtcg ggacctagcc tggtgaaacc ttctcagtct      120

ctgtccctca cctgcactgt cactggctac tcaatcacca gtgattttgc ctggaactgg      180

atccggcagt ttccaggaaa caagctggag tggatgggct acataagtta tagtggtaac      240

actaggtaca acccatctct caaaagtcga atctctatca ctcgagacac atccaagaac      300

caattcttcc tgcagttgaa ttctgtgact attgaggaca cagccacata ttactgtgta      360

acggcgggac gcgggtttcc ttattggggc caagggactc tggtcactgt ctctgcaggt      420

ggcggtggct cgggcggtgg tgggtcgggt ggcggcggat ctgacatcct gatgacccaa      480

tctccatcct ccatgtctgt atctctggga gacacagtca gcatcacttg ccattcaagt      540

caggacatta acagtaatat agggtggttg cagcagagac cagggaaatc atttaagggc      600

ctgatctatc atggaaccaa cttggacgat gaagttccat caaggttcag tggcagtgga      660

tctggagccg attattctct caccatcagc agcctggaat ctgaagattt tgcagactat      720

tactgtgtac agtatgctca gtttccgtgg acgttcggtg gaggcaccaa gctggaaatc      780

aaacgtacgc gtaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg      840

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac      900

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt      960

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1020

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1080

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1140

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1200

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1260

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1320

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1380

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1440

atgcaggccc tgccccctcg ctaagtcgac                                      1470


